|
Name |
Accession |
Description |
Interval |
E-value |
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
1-1020 |
3.98e-62 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 229.86 E-value: 3.98e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 1 MRPIQLIMTAFGPYKQKEVIDFEDLGehRIFAISGNTGAGKTTIFDAICYVLYGEASGEERSDTSmLRSQFADDNVYTSV 80
Cdd:TIGR00618 1 MKPLRLTLKNFGSYKGTHTIDFTALG--PIFLICGKTGAGKTTLLDAITYALYGKLPRRSEVIRS-LNSLYAAPSEAAFA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 81 ELTFQLKGKRYEIKRQLGHKKQGNKTITGHAVELYEVIDGENVPAVdrfHVTDVNKKMEDLIGLSKHQFSQIVMLPQGEF 160
Cdd:TIGR00618 78 ELEFSLGTKIYRVHRTLRCTRSHRKTEQPEQLYLEQKKGRGRILAA---KKSETEEVIHDLLKLDYKTFTRVVLLPQGEF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 161 RKLLTSETENKEEILRRIFKTDRYklmRELLDQKRKQWKDVLQEKQKERELYfrnvfklpirdgALLETLVAQEHVNTHQ 240
Cdd:TIGR00618 155 AQFLKAKSKEKKELLMNLFPLDQY---TQLALMEFAKKKSLHGKAELLTLRS------------QLLTLCTPCMPDTYHE 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 241 VVEVLEQETTVYKAEVEQLQVEQDVQTKQLKDAETRFHAAKSvnekfidLQQKNEKYNTLQENRAAIEGKEKSFKRAEQA 320
Cdd:TIGR00618 220 RKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLKKQQL-------LKQLRARIEELRAQEAVLEETQERINRARKA 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 321 KRLLPFEqwyEEAMQNEQKAESLLKQIIVKqeqiMNSFELAQEKYEVVKNKELEREEAKKLVQRLEELQAIIESLAERKL 400
Cdd:TIGR00618 293 APLAAHI---KAVTQIEQQAQRIHTELQSK----MRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVAT 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 401 NLQNAEIQIGKLKESMQKLDQQLEEHTSQKQGMSDELQQLEQALEQYVAKVEELTNMREDAKVLKQAYDVWQEKQKFEQE 480
Cdd:TIGR00618 366 SIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAA 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 481 -----------KEAANNKMQVAVRAYENME---RRWLSEQAGILALHLH-----DGESCPVCGSTNHPQKATEQsnaIDE 541
Cdd:TIGR00618 446 aitctaqceklEKIHLQESAQSLKEREQQLqtkEQIHLQETRKKAVVLArllelQEEPCPLCGSCIHPNPARQD---IDN 522
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 542 KELNDLRDKKNIAEKLNVQVEEKWNFYRLQYEQviEEVVKRGYNSEKLAETYSALVQKGKQLAADVN-TLKASEETRKQI 620
Cdd:TIGR00618 523 PGPLTRRMQRGEQTYAQLETSEEDVYHQLTSER--KQRASLKEQMQEIQQSFSILTQCDNRSKEDIPnLQNITVRLQDLT 600
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 621 AVNMKSVEEKIEELQKQKREVETMQHRTEM---------ECMQLRTSYEHDKRNIPEN---------------------- 669
Cdd:TIGR00618 601 EKLSEAEDMLACEQHALLRKLQPEQDLQDVrlhlqqcsqELALKLTALHALQLTLTQErvrehalsirvlpkellasrql 680
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 670 --------LQTVQAWKAQLDQAMQELRLMEDEWKKVQEAYQHWQNENIRIQAEQKGASNQFESAKLKKEETFARFMKELE 741
Cdd:TIGR00618 681 alqkmqseKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELMHQARTVLKART 760
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 742 QSGFTDQFTYKEAKLSDAQMEMLQKEIQGYYSSLEVLAKQIEELNSELKDK--EYMDITSLGEH--IKELEINLDIIKEK 817
Cdd:TIGR00618 761 EAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEipSDEDILNLQCEtlVQEEEQFLSRLEEK 840
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 818 RQRAQNAVTYISDLHENIRRIDEQIHDEEKAFQELVDLYevmkGDNESRISFERYILIEYLEQIVQIANERLRKLSNGQF 897
Cdd:TIGR00618 841 SATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDKLN----GINQIKIQFDGDALIKFLHEITLYANVRLANQSEGRF 916
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 898 YLKRSERVEKRNRQSGLGLDVYDAYTGQTRDVKTLSGGEKFNASLCLALGMADVIQAyEGGISIETMFIDEGFGSLDEES 977
Cdd:TIGR00618 917 HGRYADSHVNARKYQGLALLVADAYTGSVRPSATLSGGETFLASLSLALALADLLST-SGGTVLDSLFIDEGFGSLDEDS 995
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|...
gi 447170203 978 LTKAVDALIDLQKSGRFIGVISHVQELKNAMPAVLEVTKQKDG 1020
Cdd:TIGR00618 996 LDRAIGILDAIREGSKMIGIISHVPEFRERIPHRILVKKTNAG 1038
|
|
| ABC_sbcCD |
cd03279 |
ATP-binding cassette domain of sbcCD; SbcCD and other Mre11/Rad50 (MR) complexes are ... |
1-170 |
3.09e-36 |
|
ATP-binding cassette domain of sbcCD; SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini.
Pssm-ID: 213246 [Multi-domain] Cd Length: 213 Bit Score: 136.24 E-value: 3.09e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 1 MRPIQLIMTAFGPYKQKEVIDFEDLGEHRIFAISGNTGAGKTTIFDAICYVLYGEASGEERSDtsMLRSQFADDNVYTSV 80
Cdd:cd03279 1 MKPLKLELKNFGPFREEQVIDFTGLDNNGLFLICGPTGAGKSTILDAITYALYGKTPRYGRQE--NLRSVFAPGEDTAEV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 81 ELTFQLKGKRYEIKRQlghkkqgnktitghavelyevidgenvpavdrfhvtdvnkkmedlIGLSKHQFSQIVMLPQGEF 160
Cdd:cd03279 79 SFTFQLGGKKYRVERS---------------------------------------------RGLDYDQFTRIVLLPQGEF 113
|
170
....*....|
gi 447170203 161 RKLLTSETEN 170
Cdd:cd03279 114 DRFLARPVST 123
|
|
| PRK10246 |
PRK10246 |
exonuclease subunit SbcC; Provisional |
20-1016 |
5.69e-34 |
|
exonuclease subunit SbcC; Provisional
Pssm-ID: 182330 [Multi-domain] Cd Length: 1047 Bit Score: 141.48 E-value: 5.69e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 20 IDF--EDLGEHRIFAISGNTGAGKTTIFDAICYVLYGEASGEERSDTS----MLRsqfadDNVYTSVELTFQLKGKRYE- 92
Cdd:PRK10246 20 IDFtaEPFASNGLFAITGPTGAGKTTLLDAICLALYHETPRLNNVSQSqndlMTR-----DTAECLAEVEFEVKGEAYRa 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 93 IKRQLGHKKQGNKTITGHAVELYEVIDGENVpaVDRfhVTDVNKKMEDLIGLSKHQFSQIVMLPQGEFRKLLTSETENKE 172
Cdd:PRK10246 95 FWSQNRARNQPDGNLQAPRVELARCADGKIL--ADK--VKDKLELTATLTGLDYGRFTRSMLLSQGQFAAFLNAKPKERA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 173 EILRRIFKTDRYKLMRELLDQKRKQWKDVLQEKQKERElyfrnvfklpirdGALLETLVAQEHVNTHQVVEVLEQETTVY 252
Cdd:PRK10246 171 ELLEELTGTEIYGQISAMVFEQHKSARTELEKLQAQAS-------------GVALLTPEQVQSLTASLQVLTDEEKQLLT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 253 KAEVEQLQVEQDVQTKQL-KDAETRFHAAKSVNEKFIDLQQKNEKYNTLQENRAAIEGKEKSfkrAEQAKRLLPFEQWYE 331
Cdd:PRK10246 238 AQQQQQQSLNWLTRLDELqQEASRRQQALQQALAAEEKAQPQLAALSLAQPARQLRPHWERI---QEQSAALAHTRQQIE 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 332 EA---MQNEQKAESLLKQIIVKQEQIMNS--FELAQ-----EKYEVVKNkEL------------EREEAKKLVQRLEELQ 389
Cdd:PRK10246 315 EVntrLQSTMALRARIRHHAAKQSAELQAqqQSLNTwlaehDRFRQWNN-ELagwraqfsqqtsDREQLRQWQQQLTHAE 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 390 AIIESLAERKLNLQNAEIQIGKLKESMQK-LDQQLEEHTSQKQGMSDELQQLE---QALEQYVAKVEE-LTNMREDAKVL 464
Cdd:PRK10246 394 QKLNALPAITLTLTADEVAAALAQHAEQRpLRQRLVALHGQIVPQQKRLAQLQvaiQNVTQEQTQRNAaLNEMRQRYKEK 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 465 KQAY-DVwqeKQKFEQEKEAANNKMQVAvrayenmerrwlseqagilalHLHDGESCPVCGSTNHPqkATEQSNAIdekE 543
Cdd:PRK10246 474 TQQLaDV---KTICEQEARIKDLEAQRA---------------------QLQAGQPCPLCGSTSHP--AVEAYQAL---E 524
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 544 LNDLRDKKNIAEKLNVQVEEKWNFYRLQYEQVIEEVVKRGYNSEKLAETYSALVQKGKQLAADVNT-----------LKA 612
Cdd:PRK10246 525 PGVNQSRLDALEKEVKKLGEEGAALRGQLDALTKQLQRDESEAQSLRQEEQALTQQWQAVCASLNItlqpqddiqpwLDA 604
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 613 SEETRKQIAVnMKSVEEKIEELQKQKREVETMQHRTEMECMQLRTSYEHDKRNIPENlQTVQAWKAQLDQAMQELRLMED 692
Cdd:PRK10246 605 QEEHERQLRL-LSQRHELQGQIAAHNQQIIQYQQQIEQRQQQLLTALAGYALTLPQE-DEEASWLATRQQEAQSWQQRQN 682
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 693 EWKKVQE-------------------------AYQHWQ---NENIRIQAEQKGASNQFESAKLKKEETFARFMKELEQSG 744
Cdd:PRK10246 683 ELTALQNriqqltplletlpqsddlphseetvALDNWRqvhEQCLSLHSQLQTLQQQDVLEAQRLQKAQAQFDTALQASV 762
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 745 FTDQFTYKEAKLSD---AQMEMLQKEIQGYYSSLEVLAKQIEElnselkdkeymditSLGEHIKELEINLDIIKEKRQRA 821
Cdd:PRK10246 763 FDDQQAFLAALLDEetlTQLEQLKQNLENQRQQAQTLVTQTAQ--------------ALAQHQQHRPDGLDLTVTVEQIQ 828
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 822 QNAVTYISDLHENIRR---IDEQIHDEEKAFQELVDLYEVMkgDNESRIS-----------------FERYILIEYLEQI 881
Cdd:PRK10246 829 QELAQLAQQLRENTTRqgeIRQQLKQDADNRQQQQALMQQI--AQATQQVedwgylnsligskegdkFRKFAQGLTLDNL 906
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 882 VQIANERLRKLsNGQFYLKR--SERVEkrnrqsglgLDVYDAYTGQT-RDVKTLSGGEKFNASLCLALGMADVIQAyegG 958
Cdd:PRK10246 907 VWLANQQLTRL-HGRYLLQRkaSEALE---------LEVVDTWQADAvRDTRTLSGGESFLVSLALALALSDLVSH---K 973
|
1050 1060 1070 1080 1090
....*....|....*....|....*....|....*....|....*....|....*...
gi 447170203 959 ISIETMFIDEGFGSLDEESLTKAVDALIDLQKSGRFIGVISHVQELKNAMPAVLEVTK 1016
Cdd:PRK10246 974 TRIDSLFLDEGFGTLDSETLDTALDALDALNASGKTIGVISHVEAMKERIPVQIKVKK 1031
|
|
| ABC_sbcCD |
cd03279 |
ATP-binding cassette domain of sbcCD; SbcCD and other Mre11/Rad50 (MR) complexes are ... |
926-1020 |
2.07e-33 |
|
ATP-binding cassette domain of sbcCD; SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini.
Pssm-ID: 213246 [Multi-domain] Cd Length: 213 Bit Score: 128.16 E-value: 2.07e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 926 TRDVKTLSGGEKFNASLCLALGMADVIQAyEGGISIETMFIDEGFGSLDEESLTKAVDALIDLQKSGRFIGVISHVQELK 1005
Cdd:cd03279 118 ARPVSTLSGGETFLASLSLALALSEVLQN-RGGARLEALFIDEGFGTLDPEALEAVATALELIRTENRMVGVISHVEELK 196
|
90
....*....|....*
gi 447170203 1006 NAMPAVLEVTKQKDG 1020
Cdd:cd03279 197 ERIPQRLEVIKTPGG 211
|
|
| SbcC |
COG0419 |
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]; |
2-219 |
1.08e-27 |
|
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];
Pssm-ID: 440188 [Multi-domain] Cd Length: 204 Bit Score: 111.64 E-value: 1.08e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 2 RPIQLIMTAFGPYKQKEVIDFEDlgehRIFAISGNTGAGKTTIFDAICYVLYGEASGEERsdtsmLRSQFA-DDNVYTSV 80
Cdd:COG0419 1 KLLRLRLENFRSYRDTETIDFDD----GLNLIVGPNGAGKSTILEAIRYALYGKARSRSK-----LRSDLInVGSEEASV 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 81 ELTFQLKGKRYEIKRqlghkkqgnktitghavelyevidgenvpavdrfhvtdvnkkmedliglskhqfsqivmlPQGEF 160
Cdd:COG0419 72 ELEFEHGGKRYRIER------------------------------------------------------------RQGEF 91
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447170203 161 RKLLTSETENKEEILRRIFKTDRYKLMRELLDQKRKQWKDVLQEK---QKERELYFRNVFKL 219
Cdd:COG0419 92 AEFLEAKPSERKEALKRLLGLEIYEELKERLKELEEALESALEELaelQKLKQEILAQLSGL 153
|
|
| AAA_23 |
pfam13476 |
AAA domain; |
6-208 |
1.53e-15 |
|
AAA domain;
Pssm-ID: 463890 [Multi-domain] Cd Length: 190 Bit Score: 76.00 E-value: 1.53e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 6 LIMTAFGPYKQKEvIDFEdlgeHRIFAISGNTGAGKTTIFDAICYVLYGEASGEERSD-TSMLRSQFA---DDNVYTSVE 81
Cdd:pfam13476 1 LTIENFRSFRDQT-IDFS----KGLTLITGPNGSGKTTILDAIKLALYGKTSRLKRKSgGGFVKGDIRiglEGKGKAYVE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 82 LTFQLKGKR--YEIKRQLGHKKQGNKTITGHAVELyevidgenvpavdrFHVTDVNKKMEDLIGLSKHQFSQIVMLPQGE 159
Cdd:pfam13476 76 ITFENNDGRytYAIERSRELSKKKGKTKKKEILEI--------------LEIDELQQFISELLKSDKIILPLLVFLGQER 141
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 447170203 160 FRKLLTSETENKEEILRRIFKTDRYKLMRELLDQKRKQWKDVLQEKQKE 208
Cdd:pfam13476 142 EEEFERKEKKERLEELEKALEEKEDEKKLLEKLLQLKEKKKELEELKEE 190
|
|
| ABC_Rad50 |
cd03240 |
ATP-binding cassette domain of Rad50; The catalytic domains of Rad50 are similar to the ... |
927-1022 |
1.64e-15 |
|
ATP-binding cassette domain of Rad50; The catalytic domains of Rad50 are similar to the ATP-binding cassette of ABC transporters, but are not associated with membrane-spanning domains. The conserved ATP-binding motifs common to Rad50 and the ABC transporter family include the Walker A and Walker B motifs, the Q loop, a histidine residue in the switch region, a D-loop, and a conserved LSGG sequence. This conserved sequence, LSGG, is the most specific and characteristic motif of this family and is thus known as the ABC signature sequence.
Pssm-ID: 213207 [Multi-domain] Cd Length: 204 Bit Score: 76.11 E-value: 1.64e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 927 RDVKTLSGGEKFNASLCLALGMADVIqayegGISIETMFIDEGFGSLDEESLTKAVDALIDLQKS--GRFIGVISHVQEL 1004
Cdd:cd03240 111 DMRGRCSGGEKVLASLIIRLALAETF-----GSNCGILALDEPTTNLDEENIEESLAEIIEERKSqkNFQLIVITHDEEL 185
|
90
....*....|....*...
gi 447170203 1005 KNAMPAVLEVTKQKDGCS 1022
Cdd:cd03240 186 VDAADHIYRVEKDGRQKS 203
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
11-852 |
1.29e-14 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 78.95 E-value: 1.29e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 11 FGPYKQKEVIDFEdlgeHRIFAISGNTGAGKTTIFDAICYVLyGEASgeersdTSMLRSQFADDNV-----------YTS 79
Cdd:TIGR02168 10 FKSFADPTTINFD----KGITGIVGPNGCGKSNIVDAIRWVL-GEQS------AKALRGGKMEDVIfngsetrkplsLAE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 80 VELTF-----QLKGKRYE---IKRQLGHKKQGNKTITGHAVELYEVIdgenvpavDRFHVTDVNKKMEDLIGLSKhqFSQ 151
Cdd:TIGR02168 79 VELVFdnsdgLLPGADYSeisITRRLYRDGESEYFINGQPCRLKDIQ--------DLFLDTGLGKRSYSIIEQGK--ISE 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 152 IVMLPQGEFRKLL------TSETENKEEILRRIFKTD----------------------------RYKLMRELLDQKRKQ 197
Cdd:TIGR02168 149 IIEAKPEERRAIFeeaagiSKYKERRKETERKLERTRenldrledilnelerqlkslerqaekaeRYKELKAELRELELA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 198 -WKDVLQEKQKERELYFRNVFKLPIRDGALLETL-VAQEHVNTHQV-VEVLEQETTVYKAEVEQLQVEQ----------- 263
Cdd:TIGR02168 229 lLVLRLEELREELEELQEELKEAEEELEELTAELqELEEKLEELRLeVSELEEEIEELQKELYALANEIsrleqqkqilr 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 264 ----DVQTKQLKDAETRFHAAKSVNEKFIDLQQKNEKYNTLQENRAAIEGKEKSFKRAEQAKRLLPFEQwyEEAMQNEQK 339
Cdd:TIGR02168 309 erlaNLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEEL--EEQLETLRS 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 340 AESLLKQiivKQEQIMNSFELAQEKYEVVK-------------NKELEREEAKKLVQRLEELQAIIESLAERKLNLQNAE 406
Cdd:TIGR02168 387 KVAQLEL---QIASLNNEIERLEARLERLEdrrerlqqeieelLKKLEEAELKELQAELEELEEELEELQEELERLEEAL 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 407 IQIGKLKESMQKLDQQLEEHTSQKQGMSDELQQLEQALEQYVAKVEELTNMRED-AKVLKQAYDVWQEKQKFEQEKEAA- 484
Cdd:TIGR02168 464 EELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGlSGILGVLSELISVDEGYEAAIEAAl 543
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 485 --------NNKMQVAVRAYENMERRwLSEQAGILALHLHDGESCPVCGSTNHPQKATEQSNAID--------EKELNDLR 548
Cdd:TIGR02168 544 ggrlqavvVENLNAAKKAIAFLKQN-ELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDlvkfdpklRKALSYLL 622
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 549 DKKNIAEKLNvQVEEKWNFYRLQYEQVIEE---VVKRGYNSEKLAETYSALVQKGKQLAADVNTLKASEETRKQIAVNMK 625
Cdd:TIGR02168 623 GGVLVVDDLD-NALELAKKLRPGYRIVTLDgdlVRPGGVITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALA 701
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 626 SVEEKIEELQKQKREVETMQHRTEMECMQLRTSYEHDKRNIPENLQTVQAWKAQLDQAMQELRLMEDEWKKVQEAYQHWQ 705
Cdd:TIGR02168 702 ELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAE 781
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 706 NENIRIQAEQKGASNQFESAKLKKEETFARFmKELEQSGFTDQFTYKEAKlsdAQMEMLQKEIQGYYSSLEVLAKQIEEL 785
Cdd:TIGR02168 782 AEIEELEAQIEQLKEELKALREALDELRAEL-TLLNEEAANLRERLESLE---RRIAATERRLEDLEEQIEELSEDIESL 857
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447170203 786 NSELKDKEymdiTSLGEHIKELEINLDIIKEKRQRAQNAVTYISDLHENIRRIDEQIHDEEKAFQEL 852
Cdd:TIGR02168 858 AAEIEELE----ELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEEL 920
|
|
| ABC_Rad50 |
cd03240 |
ATP-binding cassette domain of Rad50; The catalytic domains of Rad50 are similar to the ... |
6-97 |
1.74e-12 |
|
ATP-binding cassette domain of Rad50; The catalytic domains of Rad50 are similar to the ATP-binding cassette of ABC transporters, but are not associated with membrane-spanning domains. The conserved ATP-binding motifs common to Rad50 and the ABC transporter family include the Walker A and Walker B motifs, the Q loop, a histidine residue in the switch region, a D-loop, and a conserved LSGG sequence. This conserved sequence, LSGG, is the most specific and characteristic motif of this family and is thus known as the ABC signature sequence.
Pssm-ID: 213207 [Multi-domain] Cd Length: 204 Bit Score: 67.63 E-value: 1.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 6 LIMTAFGPYKQKEVIDFEDLgehrIFAISGNTGAGKTTIFDAICYVLYGEASGEERS---DTSMLRSQfaddNVYTSVEL 82
Cdd:cd03240 4 LSIRNIRSFHERSEIEFFSP----LTLIVGQNGAGKTTIIEALKYALTGELPPNSKGgahDPKLIREG----EVRAQVKL 75
|
90
....*....|....*.
gi 447170203 83 TFQL-KGKRYEIKRQL 97
Cdd:cd03240 76 AFENaNGKKYTITRSL 91
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
385-1005 |
4.64e-12 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 70.18 E-value: 4.64e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 385 LEELQAIIESLaeRKLNLQNAEIQIGKLKESMQKLdQQLEEHTSQKQGMSDELQQLEQALEQYVAKVEELTNMREDAKVL 464
Cdd:COG4717 48 LERLEKEADEL--FKPQGRKPELNLKELKELEEEL-KEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 465 KQAYDVWQEKQKFEQEKEAANNKMQVAVRAYEN-----MERRWLSEQAGILALHLHDGEscpvcgstNHPQKATEQSNAI 539
Cdd:COG4717 125 LQLLPLYQELEALEAELAELPERLEELEERLEElreleEELEELEAELAELQEELEELL--------EQLSLATEEELQD 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 540 DEKELNDLRDKKNIAEKLNVQVEEKWNFYRLQYEQvIEEVVKRGYNSEKLAETYSALVQKGKQLAADVNTLKASEETRKQ 619
Cdd:COG4717 197 LAEELEELQQRLAELEEELEEAQEELEELEEELEQ-LENELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSLILTI 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 620 IAVNMKSVEEKIEELQKQKREVETMQHRTEmECMQLRTSYEHDKRNIPENLQTVQAWKAQLDQAMQELRLMEDEWKKVQE 699
Cdd:COG4717 276 AGVLFLVLGLLALLFLLLAREKASLGKEAE-ELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLR 354
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 700 AYQHWQNEnIRIQAEQKGASNQFESAKLKKEETFARFMKELEQsgftdqftYKEAKlsdAQMEMLQKEIQGYYSSLEVLA 779
Cdd:COG4717 355 EAEELEEE-LQLEELEQEIAALLAEAGVEDEEELRAALEQAEE--------YQELK---EELEELEEQLEELLGELEELL 422
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 780 KQIEElnSELKDKeymdITSLGEHIKELEINLDIIKEKRQRAQNAV------TYISDLHENIRRIDEQIHDEEKAFQELV 853
Cdd:COG4717 423 EALDE--EELEEE----LEELEEELEELEEELEELREELAELEAELeqleedGELAELLQELEELKAELRELAEEWAALK 496
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 854 DLYEVMkgdNESRISFERyiliEYLEQIVQIANERLRKLSNGQFylkrservEKRNRQSGLGLDVYDAyTGQTRDVKTLS 933
Cdd:COG4717 497 LALELL---EEAREEYRE----ERLPPVLERASEYFSRLTDGRY--------RLIRIDEDLSLKVDTE-DGRTRPVEELS 560
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 447170203 934 GGEKFNASLCLALGMADVIQAYeggisIETMFIDEGFGSLDEESLTKAVDALIDLQKSGRFIGVISHVQELK 1005
Cdd:COG4717 561 RGTREQLYLALRLALAELLAGE-----PLPLILDDAFVNFDDERLRAALELLAELAKGRQVIYFTCHEELVE 627
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
260-873 |
3.36e-11 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 67.86 E-value: 3.36e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 260 QVEQDVQTKQLKDAETRFHAAKSVNEKFIDLQQKNEKYNTLQENRAAIEGKEKS--FKRAEQAKRLLPFEQWYEEAMqne 337
Cdd:PTZ00121 1186 EVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAeeAKKAEEERNNEEIRKFEEARM--- 1262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 338 qkAESLLKQIIVKQEQIMNSFELAQEKyEVVKNKELEREEAKKLVQRLEELQAIIESLAERKLNLQNAEIQIGKLKESMQ 417
Cdd:PTZ00121 1263 --AHFARRQAAIKAEEARKADELKKAE-EKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAE 1339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 418 KLDQQLEEHTSQKQGMSDELQQLEQALEQYVAKVEELTNMREDAKvlKQAydvwQEKQKFEQEKEAANNKMQVAVRAYEN 497
Cdd:PTZ00121 1340 EAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAK--KKA----EEKKKADEAKKKAEEDKKKADELKKA 1413
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 498 MERRWLSEQAGILALHLHDGESCPvcGSTNHPQKATEQSNAIDEK----ELNDLRDKKNIAEKLNVQVEEKWNFYRL--- 570
Cdd:PTZ00121 1414 AAAKKKADEAKKKAEEKKKADEAK--KKAEEAKKADEAKKKAEEAkkaeEAKKKAEEAKKADEAKKKAEEAKKADEAkkk 1491
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 571 --QYEQVIEEVVKRGYNSEKLAETYSALVQKGKQLAADVNTLKASEETRKQIAVNMKSVEEKIEELQK--QKREVETMQH 646
Cdd:PTZ00121 1492 aeEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKaeEKKKAEEAKK 1571
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 647 RTEMECMQLRTSYEHDKRNIPENLQTVQAWKAQLDQAMQELRLMEDEWKKVQEAYQHWQNENIRIQAEQKGASNQFESAK 726
Cdd:PTZ00121 1572 AEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEE 1651
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 727 LKKEETFARFMKELEQsgftdqftyKEAKLSDAQMEMLQKEIQGYYSSLEVLAKQIEELN--SELKDKEYMDITSLGEHI 804
Cdd:PTZ00121 1652 LKKAEEENKIKAAEEA---------KKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKkaEELKKKEAEEKKKAEELK 1722
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447170203 805 KELEINLDIIKEKRQRAQNAVTYISDLH---------ENIRRIDEQIHDEEKAFQELVDLYEVMKGDNESRISFERYI 873
Cdd:PTZ00121 1723 KAEEENKIKAEEAKKEAEEDKKKAEEAKkdeeekkkiAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKI 1800
|
|
| PRK01156 |
PRK01156 |
chromosome segregation protein; Provisional |
33-793 |
4.75e-11 |
|
chromosome segregation protein; Provisional
Pssm-ID: 100796 [Multi-domain] Cd Length: 895 Bit Score: 67.23 E-value: 4.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 33 ISGNTGAGKTTIFDAICYVLYGEASGEERSDtsMLRSqfadDNVYTSVELTFQLKGKRYEIKRQLGHKKQGNKTitghav 112
Cdd:PRK01156 28 ITGKNGAGKSSIVDAIRFALFTDKRTEKIED--MIKK----GKNNLEVELEFRIGGHVYQIRRSIERRGKGSRR------ 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 113 ELYEVIDGENVPAvdrfHVTDVNKKME-DLIGLSKHQFSQIVMLPQGEFRKLLTSETENKEEILRRIFKTDR----YKLM 187
Cdd:PRK01156 96 EAYIKKDGSIIAE----GFDDTTKYIEkNILGISKDVFLNSIFVGQGEMDSLISGDPAQRKKILDEILEINSlernYDKL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 188 RELLDQKRKQWKDV--LQEKQKERELYFRNVFKlPIRDGALLETLVAQEHVNTHQVVEVLEQETTVYKAEVEQLQVEQDV 265
Cdd:PRK01156 172 KDVIDMLRAEISNIdyLEEKLKSSNLELENIKK-QIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDM 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 266 QTKQLKDAETRFHAAKSVNEKFIDLQQKNEKYNTLQENRAAiegkeksfkraeqAKRLLPFEQWyeeamqNEQKAESLLK 345
Cdd:PRK01156 251 KNRYESEIKTAESDLSMELEKNNYYKELEERHMKIINDPVY-------------KNRNYINDYF------KYKNDIENKK 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 346 QIIVKQEQIMNSFELAQEKYEVVKNKELEREEAKKlvqRLEELQAIIESLAERKLNLQNAeiqigklKESMQKLDQQLEE 425
Cdd:PRK01156 312 QILSNIDAEINKYHAIIKKLSVLQKDYNDYIKKKS---RYDDLNNQILELEGYEMDYNSY-------LKSIESLKKKIEE 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 426 HTSQKQGMSDELQQLeqaLEQYVAKVEELTNMREDAKVLKQAYdvwqekqkfeqekEAANNKMQVAVRAYENMERRwLSE 505
Cdd:PRK01156 382 YSKNIERMSAFISEI---LKIQEIDPDAIKKELNEINVKLQDI-------------SSKVSSLNQRIRALRENLDE-LSR 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 506 QAGILALHlhdgESCPVCGSTnhpqKATEQSNAIDE---KELNDLRDKKNIAEKLNVQVEEKWNFYRLQYEQVIEEVVKR 582
Cdd:PRK01156 445 NMEMLNGQ----SVCPVCGTT----LGEEKSNHIINhynEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEINK 516
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 583 GYNSEKLAETYSALVQKGKQlaaDVNTLKASEETRKQIAVNMKSVeeKIEEL-QKQKREVETMQHRTEMECMQLRTSYEH 661
Cdd:PRK01156 517 SINEYNKIESARADLEDIKI---KINELKDKHDKYEEIKNRYKSL--KLEDLdSKRTSWLNALAVISLIDIETNRSRSNE 591
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 662 DKRNIPENLQTVQAWKAQLDQAM----QELRLMEDEWKKVQEAYQHWQNENIRIQAEQKGASNQFESAKLKKEETFARFM 737
Cdd:PRK01156 592 IKKQLNDLESRLQEIEIGFPDDKsyidKSIREIENEANNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKE 671
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*.
gi 447170203 738 KELEQSGFTDQFTYKEAKLSDAQMEMLQKEiqgyySSLEVLAKQIEELNSELKDKE 793
Cdd:PRK01156 672 ITSRINDIEDNLKKSRKALDDAKANRARLE-----STIEILRTRINELSDRINDIN 722
|
|
| SbcC_Walker_B |
pfam13558 |
SbcC/RAD50-like, Walker B motif; This entry represents the Walker B domain of RAD50 from ... |
927-985 |
8.17e-11 |
|
SbcC/RAD50-like, Walker B motif; This entry represents the Walker B domain of RAD50 from eukaryotes and the prokaryotic homolog SbcCD complex subunit C. RAD50-ATPase forms a complex with Mre11-nuclease that detects and processes diverse and obstructed DNA ends. This domain is separated of the Walker A domain by a long coiled-coil domain and forms the nucleotide-binding domain (NBD) when the coiled coils fold back on themselves and bring together Walker A and B domains. Two RAD50-NBDs forms heterotetramers with a Mre11 nuclease dimer that assemble as catalytic head module that binds and cleaves DNA in an ATP-dependent reaction. Through secondary structural analysis, it has been suggested that there is a wide structural conservation in the Rad50/SMC protein family as seen in structural similarities between RAD50's hook and ABC-ATPase MukB's elbow region.
Pssm-ID: 463921 [Multi-domain] Cd Length: 90 Bit Score: 59.17 E-value: 8.17e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447170203 927 RDVKTLSGGEK-FNASLCLALGMADVIQAYEG-GISIETMFIDEGFGSLDEESLTKAVDAL 985
Cdd:pfam13558 28 RRSGGLSGGEKqLLAYLPLAAALAAQYGSAEGrPPAPRLVFLDEAFAKLDEENIRTALELL 88
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
330-1015 |
4.43e-10 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 63.93 E-value: 4.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 330 YEEAMQNEQKAESLLKQIIVKQEQIMNSFELAQEKYEVVKnKELER--EEAKKLVQRLEELQAIIESLAERKLNLQnaei 407
Cdd:PRK03918 160 YENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKE-KELEEvlREINEISSELPELREELEKLEKEVKELE---- 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 408 qigKLKESMQKLDQQLEEHTSQKQGMSDELQQLEQALEQYVAKVEELTNMREDAKVLKQAYDVWQEKQKFEQEKEAANNK 487
Cdd:PRK03918 235 ---ELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEEYLDELRE 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 488 MqvavrayENMERRWLSEQAGILALhLHDGEScpvcgstnHPQKATEQSNAIDE--KELNDLRDKKNIAEKLNVQVEEKW 565
Cdd:PRK03918 312 I-------EKRLSRLEEEINGIEER-IKELEE--------KEERLEELKKKLKEleKRLEELEERHELYEEAKAKKEELE 375
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 566 NFYRLQYEQVIEEVVKRGYNSEK-----------LAETYSALVQKGKQLAADVNTLKA------------SEETR----- 617
Cdd:PRK03918 376 RLKKRLTGLTPEKLEKELEELEKakeeieeeiskITARIGELKKEIKELKKAIEELKKakgkcpvcgrelTEEHRkelle 455
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 618 ------KQIAVNMKSVEEKIEELQKQKREVETMQHRtEMECMQLRTSYEHdKRNIPENLQTVQAWKaqLDQAMQELRLME 691
Cdd:PRK03918 456 eytaelKRIEKELKEIEEKERKLRKELRELEKVLKK-ESELIKLKELAEQ-LKELEEKLKKYNLEE--LEKKAEEYEKLK 531
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 692 DEWKKVqEAYQHWQNENIRIQAEQKGASNQFESAKLKKEETFARFMKELEQSGFTD------------------------ 747
Cdd:PRK03918 532 EKLIKL-KGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFESveeleerlkelepfyneylelkda 610
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 748 ----QFTYKEAKLSDAQMEMLQKEIQGYYSSLEVLAKQIEELNSELKDKEYMDI----TSLGEHIKELEINLDIIKEKRQ 819
Cdd:PRK03918 611 ekelEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEEEYEELreeyLELSRELAGLRAELEELEKRRE 690
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 820 RAQNAVTYISDLHENIRRIDEQIHDEEKAFQELVDLYEVMKgdnESRISFERYIlieyLEQIVQIANERLRKLSNGqfyl 899
Cdd:PRK03918 691 EIKKTLEKLKEELEEREKAKKELEKLEKALERVEELREKVK---KYKALLKERA----LSKVGEIASEIFEELTEG---- 759
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 900 KRSERVEKRNRQSglgLDVYDAYTGQTRDVKTLSGGEKFNASLCLALGMAdviqAYEGGiSIETMFIDEGFGSLDEESLT 979
Cdd:PRK03918 760 KYSGVRVKAEENK---VKLFVVYQGKERPLTFLSGGERIALGLAFRLALS----LYLAG-NIPLLILDEPTPFLDEERRR 831
|
730 740 750
....*....|....*....|....*....|....*.
gi 447170203 980 KAVDALIDLQKSGRFIGVISHVQELKNAMPAVLEVT 1015
Cdd:PRK03918 832 KLVDIMERYLRKIPQVIIVSHDEELKDAADYVIRVS 867
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
1-834 |
7.04e-09 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 60.05 E-value: 7.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 1 MRPIQLIMTAFGPYKQKEViDFEDlgehRIFAISGNTGAGKTTIFDAICYVLYGEASGEERSDTSMLRSqfADDnvyTSV 80
Cdd:PRK02224 1 MRFDRVRLENFKCYADADL-RLED----GVTVIHGVNGSGKSSLLEACFFALYGSKALDDTLDDVITIG--AEE---AEI 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 81 ELTFQLKGKRYEIKRQLghKKQGNKTITGHAV--ELYEVIDGenvpavdrfhVTDVNKKMEDLIGLSKHQFSQIVMLPQG 158
Cdd:PRK02224 71 ELWFEHAGGEYHIERRV--RLSGDRATTAKCVleTPEGTIDG----------ARDVREEVTELLRMDAEAFVNCAYVRQG 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 159 EFRKLLTSETENKEEILRRIFKTDRYKLMRELLDQKRKQWKDVLQEKqkerelyfRNVFklpirdGALLETLVAQEHVNT 238
Cdd:PRK02224 139 EVNKLINATPSDRQDMIDDLLQLGKLEEYRERASDARLGVERVLSDQ--------RGSL------DQLKAQIEEKEEKDL 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 239 HQVVEVLEQETTVYKAEVEQLQVEQDVQTKQLKDAETRfhaaksvnekfidLQQKNEKYNTLQENRAAIEGKEKSFKRAE 318
Cdd:PRK02224 205 HERLNGLESELAELDEEIERYEEQREQARETRDEADEV-------------LEEHEERREELETLEAEIEDLRETIAETE 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 319 QAKrllpfeqwyeeamqneqkaESLLKQIIVKQEQIMnsfELAQEKYEVVKNKELEREEAKKLVQRLEELQA----IIES 394
Cdd:PRK02224 272 RER-------------------EELAEEVRDLRERLE---ELEEERDDLLAEAGLDDADAEAVEARREELEDrdeeLRDR 329
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 395 LAERKLNLQNAEIQIGKLKESMQKLDQQLEEHTSQKQGMSDELQQLEQALEQYVAKVEELtnmREDAKVLKQAY------ 468
Cdd:PRK02224 330 LEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEEL---EEEIEELRERFgdapvd 406
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 469 --DVWQEKQKFEQEKEAANNKMQVAVRAYENMERRWLSEQAgilalhLHDGESCPVCGstnHPQKATEQSNAIDEKelnd 546
Cdd:PRK02224 407 lgNAEDFLEELREERDELREREAELEATLRTARERVEEAEA------LLEAGKCPECG---QPVEGSPHVETIEED---- 473
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 547 lRDKKniaEKLNVQVEEkwnfyrlqYEQVIEEVVKRGYNSEKLAETySALVQKGKQLAADVNTLKASEETRkqiavnMKS 626
Cdd:PRK02224 474 -RERV---EELEAELED--------LEEEVEEVEERLERAEDLVEA-EDRIERLEERREDLEELIAERRET------IEE 534
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 627 VEEKIEELQKQKREVETMQHRTEMECMQLRTSYEhDKRnipENLQTVQAWKAQLDQAMQELRLMEDEWKKVQEAYQhwQN 706
Cdd:PRK02224 535 KRERAEELRERAAELEAEAEEKREAAAEAEEEAE-EAR---EEVAELNSKLAELKERIESLERIRTLLAAIADAED--EI 608
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 707 ENIRIQAEQKGASNQFESAKLKKEETFARfmkELEqsgftdqftykeAKLSDAQMEMLQKEIQGYYSSLEVLAKQIEELN 786
Cdd:PRK02224 609 ERLREKREALAELNDERRERLAEKRERKR---ELE------------AEFDEARIEEAREDKERAEEYLEQVEEKLDELR 673
|
810 820 830 840
....*....|....*....|....*....|....*....|....*...
gi 447170203 787 SElKDKEYMDITSLGEHIKELEInldiIKEKRQRAQNAVTYISDLHEN 834
Cdd:PRK02224 674 EE-RDDLQAEIGAVENELEELEE----LRERREALENRVEALEALYDE 716
|
|
| SbcC |
COG0419 |
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]; |
858-1001 |
1.13e-08 |
|
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];
Pssm-ID: 440188 [Multi-domain] Cd Length: 204 Bit Score: 56.17 E-value: 1.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 858 VMKGDNESRISFE------RYILI----EYLEQIVQIANER---LRKLSNGQFYLKRSERVEKRNRQSGLGLDVYDAYTG 924
Cdd:COG0419 62 INVGSEEASVELEfehggkRYRIErrqgEFAEFLEAKPSERkeaLKRLLGLEIYEELKERLKELEEALESALEELAELQK 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 925 QTR----------DVKTLSGGEKfnaslcLALGMADVIQayeggisietMFIDegFGSLDEESLTKAVDALIDLQksgrf 994
Cdd:COG0419 142 LKQeilaqlsgldPIETLSGGER------LRLALADLLS----------LILD--FGSLDEERLERLLDALEELA----- 198
|
....*..
gi 447170203 995 igVISHV 1001
Cdd:COG0419 199 --IITHV 203
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
253-739 |
2.65e-08 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 58.23 E-value: 2.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 253 KAEVEQLQVEQDVQTKQLKDAETRFHAAKSVNEKFIDLQQKNEKyntlqENRAAIEGKEKSFKRAEQAKRLLPFEQWYEE 332
Cdd:PTZ00121 1321 KKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEE-----KAEAAEKKKEEAKKKADAAKKKAEEKKKADE 1395
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 333 AMQNEQKAESLLKQIIVKQEQIMNSFELAQEKYEVVKNKELER--EEAKK---LVQRLEELQAIiESLAERKLNLQNAEi 407
Cdd:PTZ00121 1396 AKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKkaEEAKKadeAKKKAEEAKKA-EEAKKKAEEAKKAD- 1473
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 408 QIGKLKESMQKLDQqLEEHTSQKQGMSDELQQLEQALEqyvaKVEELTNMREDAKV--LKQAydvwQEKQKFEQEKEAAN 485
Cdd:PTZ00121 1474 EAKKKAEEAKKADE-AKKKAEEAKKKADEAKKAAEAKK----KADEAKKAEEAKKAdeAKKA----EEAKKADEAKKAEE 1544
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 486 NKMQVAVRAYENMERrwlSEQAGILALHLHDGEScpvcgsTNHPQKATEQSNAIDEKELNDLRDKKNIAEKLNVQVEEKW 565
Cdd:PTZ00121 1545 KKKADELKKAEELKK---AEEKKKAEEAKKAEED------KNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKA 1615
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 566 NFYRLQYEQV--IEEVVKRgynSEKLAETYSALVQKGKQL--AADVNTLKASEETRKQIAVNMKSVEEKIEELQKQKREV 641
Cdd:PTZ00121 1616 EEAKIKAEELkkAEEEKKK---VEQLKKKEAEEKKKAEELkkAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAE 1692
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 642 ETMQHRTEM-ECMQLRTSYEHDKRNIPENLQTVQAWKAQLDQAMQElrlMEDEWKKVQEAYQHwQNENIRIQAEQKGASN 720
Cdd:PTZ00121 1693 ALKKEAEEAkKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKE---AEEDKKKAEEAKKD-EEEKKKIAHLKKEEEK 1768
|
490
....*....|....*....
gi 447170203 721 QFESAKLKKEETFARFMKE 739
Cdd:PTZ00121 1769 KAEEIRKEKEAVIEEELDE 1787
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
5-881 |
2.79e-08 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 58.06 E-value: 2.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 5 QLIMTAFGPYKQKEVIDFEdlgeHRIFAISGNTGAGKTTIFDAICYVLYGEASGEERSD--TSMLRSQFADDNVYTSVEL 82
Cdd:pfam02463 4 RIEIEGFKSYAKTVILPFS----PGFTAIVGPNGSGKSNILDAILFVLGERSAKSLRSErlSDLIHSKSGAFVNSAEVEI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 83 TFQLKGKR-------YEIKRQLGHKKQGNKTITGHAVELYEVIDGENVPAVDRFHVTDVNKKMEDLIGLSK----HQFSQ 151
Cdd:pfam02463 80 TFDNEDHElpidkeeVSIRRRVYRGGDSEYYINGKNVTKKEVAELLESQGISPEAYNFLVQGGKIEIIAMMkperRLEIE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 152 IVMLPQGEFRKL------LTSETENKEEILRRI--FKTDRYKLMRELLDQKRKQWKDVLQEKQKERELY---------FR 214
Cdd:pfam02463 160 EEAAGSRLKRKKkealkkLIEETENLAELIIDLeeLKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYldylklneeRI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 215 NVFKLPIRDGALLETLVAQEHVNTHQVVEVLEQETTVYKAEVEQLQVEQDVQTKQLKDAETRFHAAKSVNEKFIDLQQKN 294
Cdd:pfam02463 240 DLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKES 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 295 EKYNTLQE---NRAAIEGKEKSFKRAEQAKRLLPFEQWYEEAMQNEQKAESLLKQIIVKQ----EQIMNSFELAQEKYEV 367
Cdd:pfam02463 320 EKEKKKAEkelKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKklesERLSSAAKLKEEELEL 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 368 VKNKELEREEAKKLVQRLEELQAIIESLAERKLNLQNAEIQIGKLKESMQKLDQQLEEHTSQKQGMSDELQQLEQALEQY 447
Cdd:pfam02463 400 KSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQL 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 448 VAKVEELTNMREDAKvLKQAYDVWQEKQKFE---------------QEKEAANNKMQVAVRAYENMERRWLSEQAGILAL 512
Cdd:pfam02463 480 VKLQEQLELLLSRQK-LEERSQKESKARSGLkvllalikdgvggriISAHGRLGDLGVAVENYKVAISTAVIVEVSATAD 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 513 HLHDGESC--------PVCGSTNHPQKATEQSNAIDEKELNDLRDKKNIAEKLNVQVEEKWNFYRLQYEQVIEEVVKRGY 584
Cdd:pfam02463 559 EVEERQKLvraltelpLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLK 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 585 NSEKLAETYSALVQKGKQLAADVNTLKASEETRKQIAVNMKSVEEKIEELQKQKREVETMQhrtEMECMQLRTSYEHDKR 664
Cdd:pfam02463 639 ESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQL---EIKKKEQREKEELKKL 715
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 665 NIPENLQTVQAWKAQLDQAMQELRLMEDEWKKVQEAYQHWQNENIRIQAEQKGASNQFESA--------KLKKEETFARF 736
Cdd:pfam02463 716 KLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELaeerekteKLKVEEEKEEK 795
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 737 MKELEQSGFTDQFTYK-EAKLSDAQMEMLQKEIQGYYSSLEVLAKQIEELNSELKDKEYMDITSLGEHIKELEINLDIIK 815
Cdd:pfam02463 796 LKAQEEELRALEEELKeEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLK 875
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447170203 816 EKRQRAQNAVTYISDLHENIRRIDEQIHDEEKAFQELVDLYEVmkgdNESRISFERYILIEYLEQI 881
Cdd:pfam02463 876 EEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENE----IEERIKEEAEILLKYEEEP 937
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
243-777 |
1.77e-07 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 55.53 E-value: 1.77e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 243 EVLEQETTVYKAEVEQLQVEQDVQTKQLKDAETRFHAAKSVNEKFIDLQQKNEKYNTLQENRAAIEGKeksfKRAEQAKR 322
Cdd:PTZ00121 1409 ELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAK----KKAEEAKK 1484
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 323 LlpfEQWYEEAMQNEQKAESLLKQIIVKQEQimnsfELAQEKYEVVKNKELEREEAKKLVQRLEELQAIIESLAERKLNL 402
Cdd:PTZ00121 1485 A---DEAKKKAEEAKKKADEAKKAAEAKKKA-----DEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEE 1556
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 403 QNAEIQIGKLKESmqkldQQLEEHTSQKQGMSDELQQLEQaleqyvAKVEELTNMREDAKVLK--QAYDVWQEKQKFEQE 480
Cdd:PTZ00121 1557 LKKAEEKKKAEEA-----KKAEEDKNMALRKAEEAKKAEE------ARIEEVMKLYEEEKKMKaeEAKKAEEAKIKAEEL 1625
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 481 KEAANNKMQVAVRAYENMERRWLSEQagilalhLHDGESCPVCGSTNHPQKATEQSNAIDEKELNDlRDKKNIAEKLNVQ 560
Cdd:PTZ00121 1626 KKAEEEKKKVEQLKKKEAEEKKKAEE-------LKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAE-EDEKKAAEALKKE 1697
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 561 VEEKWNFYRLQYEQviEEVVKRGYNSEKLAETYSALVQKGKQLAAD----VNTLKASEETRKQIAVNMKSVEEKIEELQK 636
Cdd:PTZ00121 1698 AEEAKKAEELKKKE--AEEKKKAEELKKAEEENKIKAEEAKKEAEEdkkkAEEAKKDEEEKKKIAHLKKEEEKKAEEIRK 1775
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 637 QKREV--ETMQHRTEMECMQLRTSYEHDKRNIP-------ENLQTVQAWKAQLDQAMQELRLMEDEWKKVQEAYQHWQNE 707
Cdd:PTZ00121 1776 EKEAVieEELDEEDEKRRMEVDKKIKDIFDNFAniieggkEGNLVINDSKEMEDSAIKEVADSKNMQLEEADAFEKHKFN 1855
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 708 NIRIQAEQKGASNQFESAKLKKEEtfarFMKELEQSGFTDQFTYKEAKLSDAQMEMLQKEIQGYYSSLEV 777
Cdd:PTZ00121 1856 KNNENGEDGNKEADFNKEKDLKED----DEEEIEEADEIEKIDKDDIEREIPNNNMAGKNNDIIDDKLDK 1921
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
189-461 |
3.90e-07 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 54.29 E-value: 3.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 189 ELLDQKRKQWKDVLQEKQKERELYFRNVFKLPIRDGALLETLVAQEhvnthQVVEVLEQETTVYKAEVEQLQVEQDVQTK 268
Cdd:TIGR02168 694 AELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLE-----AEVEQLEERIAQLSKELTELEAEIEELEE 768
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 269 QLKDAETRFHAAKSVNEKfidLQQKNEKYNT-LQENRAAIEGKEKSFK--RAEQAKRLLPFEQWYEEAMQNEQKAESLLK 345
Cdd:TIGR02168 769 RLEEAEEELAEAEAEIEE---LEAQIEQLKEeLKALREALDELRAELTllNEEAANLRERLESLERRIAATERRLEDLEE 845
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 346 QIIVKQEQIMnSFELAQEKYEvvknkELEREEAKKLVQRLEELQAIIESLAERKLNLQNAEIQIGKLKESMQKLDQQLEE 425
Cdd:TIGR02168 846 QIEELSEDIE-SLAAEIEELE-----ELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEE 919
|
250 260 270
....*....|....*....|....*....|....*.
gi 447170203 426 HTSQKQGMSDELQQLEQALEQYVAKVEELTNMREDA 461
Cdd:TIGR02168 920 LREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEE 955
|
|
| 46 |
PHA02562 |
endonuclease subunit; Provisional |
33-463 |
6.06e-07 |
|
endonuclease subunit; Provisional
Pssm-ID: 222878 [Multi-domain] Cd Length: 562 Bit Score: 53.48 E-value: 6.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 33 ISGNTGAGKTTIFDAICYVLYGeasgeeRSDTSMLRSQFADDNVY--TSVELTFQLKGKRYEIKRqlghkkqgnktitGH 110
Cdd:PHA02562 32 ITGKNGAGKSTMLEALTFALFG------KPFRDIKKGQLINSINKkdLLVELWFEYGEKEYYIKR-------------GI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 111 AVELYEVI-DGENVP--AVDRfhvtDVNKKMEDLIGLSKHQFSQIVMLPQGEFRKLLTSETENkeeilrrifktdRYKLM 187
Cdd:PHA02562 93 KPNVFEIYcNGKLLDesASSK----DFQKYFEQMLGMNYKSFKQIVVLGTAGYVPFMQLSAPA------------RRKLV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 188 RELLDQKRKQWKDVLQeKQKERELYfrnvfklpiRDGALLETLV--AQEHVNTHQvvEVLEQETTVYKAEVEQLqveQDV 265
Cdd:PHA02562 157 EDLLDISVLSEMDKLN-KDKIRELN---------QQIQTLDMKIdhIQQQIKTYN--KNIEEQRKKNGENIARK---QNK 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 266 QTKQLKDAETRFHAAKSVNEKFIDLQQKNEKY----NTLQENRAAIEGKEKSFKRAeqakrllpfEQWYEE------AMQ 335
Cdd:PHA02562 222 YDELVEEAKTIKAEIEELTDELLNLVMDIEDPsaalNKLNTAAAKIKSKIEQFQKV---------IKMYEKggvcptCTQ 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 336 NEQKAESLLKQIIVKQEQIMNSFELAQEKYEVVKNKElerEEAKKLVQRLEELQAIIESLaerKLNLQNAEIQIGKLKES 415
Cdd:PHA02562 293 QISEGPDRITKIKDKLKELQHSLEKLDTAIDELEEIM---DEFNEQSKKLLELKNKISTN---KQSLITLVDKAKKVKAA 366
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 447170203 416 MQKLDQQLEEHTSQKQGMSDELQQLEQALEQYVAKVEE---LTNMREDAKV 463
Cdd:PHA02562 367 IEELQAEFVDNAEELAKLQDELDKIVKTKSELVKEKYHrgiVTDLLKDSGI 417
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
32-482 |
6.15e-07 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 53.92 E-value: 6.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 32 AISGNTGAGKTTIFDAICYVLYGEASGEERSDT-SML--RSQFADDNVYTSVELTFQLKGKR----YEIKRQLGHKKQGN 104
Cdd:TIGR02169 27 VISGPNGSGKSNIGDAILFALGLSSSKAMRAERlSDLisNGKNGQSGNEAYVTVTFKNDDGKfpdeLEVVRRLKVTDDGK 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 105 KT---ITGHAVELYEVIDgenvpAVDRFHVT----------DVNKkmedliglskhqfsqIVMLPQGEFRKLL-----TS 166
Cdd:TIGR02169 107 YSyyyLNGQRVRLSEIHD-----FLAAAGIYpegynvvlqgDVTD---------------FISMSPVERRKIIdeiagVA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 167 ETENKEEILRRIFKTDRYKLMR--ELLDQKRKQwkdvLQEKQKERElyfrnvfkLPIRDGALLETLVAQEHVNTHQVVEV 244
Cdd:TIGR02169 167 EFDRKKEKALEELEEVEENIERldLIIDEKRQQ----LERLRRERE--------KAERYQALLKEKREYEGYELLKEKEA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 245 LEQETTVYKAEVEQLQVEQDVQTKQLKDAETRFHAA----KSVNEKFIDLQQknEKYNTLQENRAAIEGKEKSFKRAEQA 320
Cdd:TIGR02169 235 LERQKEAIERQLASLEEELEKLTEEISELEKRLEEIeqllEELNKKIKDLGE--EEQLRVKEKIGELEAEIASLERSIAE 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 321 KrllpfEQWYEEAMQNEQKAESLLKQIIVKQEQIMNSFELAQEKYEVVKNKELE-REEAKKLVQRLEELQAiieSLAERK 399
Cdd:TIGR02169 313 K-----ERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAElKEELEDLRAELEEVDK---EFAETR 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 400 LNLQNAEIQIGKLKESMQKLDQQLEEHTSQKQGMSDELQQLEQALEQYVAKVEELTNMREDAkvlkqAYDVWQEKQKFEQ 479
Cdd:TIGR02169 385 DELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDK-----ALEIKKQEWKLEQ 459
|
...
gi 447170203 480 EKE 482
Cdd:TIGR02169 460 LAA 462
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
243-512 |
7.27e-07 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 53.40 E-value: 7.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 243 EVLEQETTVYKAEVEQLQVEQDVQTKQLKDAETRFHAAKSvnekfiDLQQKNEKYNTLQENRAAIEGKEKSFKRAEQAKR 322
Cdd:COG1196 235 RELEAELEELEAELEELEAELEELEAELAELEAELEELRL------ELEELELELEEAQAEEYELLAELARLEQDIARLE 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 323 llpfeqwyEEAMQNEQKAESLLKQIIVKQEQImnsfELAQEKyevvknkelEREEAKKLVQRLEELQAIIESLAERKLNL 402
Cdd:COG1196 309 --------ERRRELEERLEELEEELAELEEEL----EELEEE---------LEELEEELEEAEEELEEAEAELAEAEEAL 367
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 403 QNAEIQIGKLKESMQKLDQQLEEHTSQKQGMSDELQQLEQALEQYVAKVEELTNMREDAKvlkqaydvwQEKQKFEQEKE 482
Cdd:COG1196 368 LEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELE---------EALAELEEEEE 438
|
250 260 270
....*....|....*....|....*....|
gi 447170203 483 AANNKMQVAVRAYENMERRWLSEQAGILAL 512
Cdd:COG1196 439 EEEEALEEAAEEEAELEEEEEALLELLAEL 468
|
|
| ABC_Class2 |
cd03227 |
ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems ... |
5-88 |
9.49e-07 |
|
ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems involved in cellular processes other than transport. These families are characterized by the fact that the ABC subunit is made up of duplicated, fused ABC modules (ABC2). No known transmembrane proteins or domains are associated with these proteins.
Pssm-ID: 213194 [Multi-domain] Cd Length: 162 Bit Score: 49.67 E-value: 9.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 5 QLIMTAFGPYKQKEVIDFedlGEHRIFAISGNTGAGKTTIFDAICYVLYGEASGEERSDTSMLRSQFAddnvYTSVELTF 84
Cdd:cd03227 1 KIVLGRFPSYFVPNDVTF---GEGSLTIITGPNGSGKSTILDAIGLALGGAQSATRRRSGVKAGCIVA----AVSAELIF 73
|
....
gi 447170203 85 QLKG 88
Cdd:cd03227 74 TRLQ 77
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
415-842 |
2.83e-06 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 51.60 E-value: 2.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 415 SMQKLDQQLEEHTSQKQGMSDELQQLEQALEQYVAKVEELTNMREDAKvlkqaydvwQEKQKFEQEKEAANNKMQVAVRA 494
Cdd:TIGR02168 671 SILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLR---------KELEELSRQISALRKDLARLEAE 741
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 495 YENMERRWLSEQAGILALhlhdgescpvcgstnhpqkateqsnaidEKELNDLRDKKNIAEKLNVQVEEKWNFYRLQYEQ 574
Cdd:TIGR02168 742 VEQLEERIAQLSKELTEL----------------------------EAEIEELEERLEEAEEELAEAEAEIEELEAQIEQ 793
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 575 VIEEVvkrgynsEKLAETYSALVQKGKQLAADVNTLkasEETRKQIAVNMKSVEEKIEELQKQKREVETMQHRTEMECMQ 654
Cdd:TIGR02168 794 LKEEL-------KALREALDELRAELTLLNEEAANL---RERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEE 863
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 655 LRTSyehdkrnIPENLQTVQAWKAQLDQAMQELRLMEDEWKKVQEAYQHWQNENIRIQAEQKGASNQFESAKLKKEETfa 734
Cdd:TIGR02168 864 LEEL-------IEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGL-- 934
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 735 rfmkELEQSGFTDQFTykeAKLSDAQMEMLQKEiqgyysslevlaKQIEELNSELKDKeymdITSLGEHIKEL-EINLDI 813
Cdd:TIGR02168 935 ----EVRIDNLQERLS---EEYSLTLEEAEALE------------NKIEDDEEEARRR----LKRLENKIKELgPVNLAA 991
|
410 420 430
....*....|....*....|....*....|..
gi 447170203 814 I---KEKRQRAQNAVTYISDLHENIRRIDEQI 842
Cdd:TIGR02168 992 IeeyEELKERYDFLTAQKEDLTEAKETLEEAI 1023
|
|
| SCP-1 |
pfam05483 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
287-768 |
3.18e-06 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 51.26 E-value: 3.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 287 FIDLQQKNEKYNT-LQENRAAIEGK--EKSFKRAEQAKRLLPFEQWYEEAMQNEQKAESLLKQIIVKQEQIMN--SFELA 361
Cdd:pfam05483 185 YMDLNNNIEKMILaFEELRVQAENArlEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKdlTFLLE 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 362 QEKYEVVKNKELEREEAKKLVQRLEELQAIIESLAERKLNLQNAEIQIGKLKESMQKLDQQLEEHTSQKQGMSDELQQLE 441
Cdd:pfam05483 265 ESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAK 344
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 442 QALEQYVAKVEELTNMREDAKVLKQaydvwQEKQKFEQEKEAANNKMQVAVRAYENMERRWLSEQAGILALHLHDGESCP 521
Cdd:pfam05483 345 AAHSFVVTEFEATTCSLEELLRTEQ-----QRLEKNEDQLKIITMELQKKSSELEEMTKFKNNKEVELEELKKILAEDEK 419
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 522 VCGSTNHPQKATEQSNAIDEKELNDLRDKKNIAEKLNVQV---EEKWNFYRLQYEQVIEEVVKRGYNSEKLAETYSALVQ 598
Cdd:pfam05483 420 LLDEKKQFEKIAEELKGKEQELIFLLQAREKEIHDLEIQLtaiKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLL 499
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 599 KGKQLAADVNTLKASEETRKQIAVNMKSVEEK----IEELQKQKREV---------ETMQHRTEMECmQLRTSYEHDKRN 665
Cdd:pfam05483 500 ENKELTQEASDMTLELKKHQEDIINCKKQEERmlkqIENLEEKEMNLrdelesvreEFIQKGDEVKC-KLDKSEENARSI 578
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 666 IPENLQTVQAWKAQLDQAMQELRLMEDEWKKVQEAYQHWQNENIRIQAEQKGASN----------QFESAKLKKEETFAR 735
Cdd:pfam05483 579 EYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNAyeikvnklelELASAKQKFEEIIDN 658
|
490 500 510
....*....|....*....|....*....|....*.
gi 447170203 736 FMKELEQSGFTDQFTYKE---AKLSDAQMEMLQKEI 768
Cdd:pfam05483 659 YQKEIEDKKISEEKLLEEvekAKAIADEAVKLQKEI 694
|
|
| ABC_Class2 |
cd03227 |
ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems ... |
929-1023 |
3.60e-06 |
|
ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems involved in cellular processes other than transport. These families are characterized by the fact that the ABC subunit is made up of duplicated, fused ABC modules (ABC2). No known transmembrane proteins or domains are associated with these proteins.
Pssm-ID: 213194 [Multi-domain] Cd Length: 162 Bit Score: 48.12 E-value: 3.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 929 VKTLSGGEKFNASLCLALGMADVIqayeggiSIETMFIDEGFGSLDEESLTKAVDALIDLQKSGRFIGVISHVQELKNAM 1008
Cdd:cd03227 75 RLQLSGGEKELSALALILALASLK-------PRPLYILDEIDRGLDPRDGQALAEAILEHLVKGAQVIVITHLPELAELA 147
|
90
....*....|....*
gi 447170203 1009 PAVLEVTKQKDGCSQ 1023
Cdd:cd03227 148 DKLIHIKKVITGVYK 162
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
295-988 |
5.66e-06 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 50.68 E-value: 5.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 295 EKYNTLQENRAAIEGKEKSFKRA-EQAKRLLPFEQWYEEAMQNEQKAEsllkqiivKQEQIMNSFEL--AQEKYEVVKNK 371
Cdd:COG4913 225 EAADALVEHFDDLERAHEALEDArEQIELLEPIRELAERYAAARERLA--------ELEYLRAALRLwfAQRRLELLEAE 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 372 -ELEREEAKKLVQRLEELQAIIESLAERKLNLQNAEIQIGKlkESMQKLDQQLEEHTSQKQGMSDELQQLEQALEQ---- 446
Cdd:COG4913 297 lEELRAELARLEAELERLEARLDALREELDELEAQIRGNGG--DRLEQLEREIERLERELEERERRRARLEALLAAlglp 374
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 447 YVAKVEELTNMREDAKVLKQAYDvwQEKQKFEQEKEAANNKMQVAVRAYENM--ERRWLSEQAGILALHLHD--GESCPV 522
Cdd:COG4913 375 LPASAEEFAALRAEAAALLEALE--EELEALEEALAEAEAALRDLRRELRELeaEIASLERRKSNIPARLLAlrDALAEA 452
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 523 CGSTNHP--------QKATEQS---NAIdEKELNDLRdkkniaekLNVQVEEKW-----NFY-------RLQYEQVIEEV 579
Cdd:COG4913 453 LGLDEAElpfvgeliEVRPEEErwrGAI-ERVLGGFA--------LTLLVPPEHyaaalRWVnrlhlrgRLVYERVRTGL 523
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 580 VK----------------------RGYNSEKLAETYS---------------------------ALVQKGKQLAAD---- 606
Cdd:COG4913 524 PDperprldpdslagkldfkphpfRAWLEAELGRRFDyvcvdspeelrrhpraitragqvkgngTRHEKDDRRRIRsryv 603
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 607 ---VNT--LKASEETRKQIAVNMKSVEEKIEELQKQKREVEtmQHRTEMECMQLRTSYEHDKRNIPENLQTVQAWKAQLD 681
Cdd:COG4913 604 lgfDNRakLAALEAELAELEEELAEAEERLEALEAELDALQ--ERREALQRLAEYSWDEIDVASAEREIAELEAELERLD 681
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 682 QAMQELRLMEDEWKKVQEAYQHWQNENIRIQAEQKGASNQFESAKLKKEETFARFmKELEQSGFTDQFTYKEAKLSDAQM 761
Cdd:COG4913 682 ASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRL-EAAEDLARLELRALLEERFAAALG 760
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 762 EMLQKEI-QGYYSSLEVLAKQIEELNSELKD------KEYMDIT--------SLGEHIKELE-INLDIIKEKRQRAQNAV 825
Cdd:COG4913 761 DAVERELrENLEERIDALRARLNRAEEELERamrafnREWPAETadldadleSLPEYLALLDrLEEDGLPEYEERFKELL 840
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 826 T---------YISDLHENIRRIDEQI--------------------------HDEEKAFQElvDLYEVMKG-----DNES 865
Cdd:COG4913 841 NensiefvadLLSKLRRAIREIKERIdplndslkripfgpgrylrlearprpDPEVREFRQ--ELRAVTSGaslfdEELS 918
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 866 RISFERyilieyLEQIVqianERLRKlSNGQFYLKRSERV-----------EKRNRQSGlglDVYDAYtgqtRDVKTLSG 934
Cdd:COG4913 919 EARFAA------LKRLI----ERLRS-EEEESDRRWRARVldvrnhlefdaEEIDREDG---EEVETY----SSSGGKSG 980
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447170203 935 GEKFN-------ASLCLALGMADviqayEGGISIETMFIDEGFGSLDEESLTKAVDALIDL 988
Cdd:COG4913 981 GEKQKlayfilaAALAYQLGLEG-----RGRPSFRTVVLDEAFSKMDEEFARRALRLFKEL 1036
|
|
| ABC_SMC_head |
cd03239 |
The SMC head domain belongs to the ATP-binding cassette superfamily; The structural ... |
5-96 |
6.63e-06 |
|
The SMC head domain belongs to the ATP-binding cassette superfamily; The structural maintenance of chromosomes (SMC) proteins are essential for successful chromosome transmission during replication and segregation of the genome in all organisms. SMCs are generally present as single proteins in bacteria, and as at least six distinct proteins in eukaryotes. The proteins range in size from approximately 110 to 170 kDa, and each has five distinct domains: amino- and carboxy-terminal globular domains, which contain sequences characteristic of ATPases, two coiled-coil regions separating the terminal domains , and a central flexible hinge. SMC proteins function together with other proteins in a range of chromosomal transactions, including chromosome condensation, sister-chromatid cohesion, recombination, DNA repair, and epigenetic silencing of gene expression.
Pssm-ID: 213206 [Multi-domain] Cd Length: 178 Bit Score: 47.69 E-value: 6.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 5 QLIMTAFGPYKQKEVIDfedlGEHRIFAISGNTGAGKTTIFDAICYVLYGEASGEERSDTSMLRSQFADDNVYT-SVELT 83
Cdd:cd03239 3 QITLKNFKSYRDETVVG----GSNSFNAIVGPNGSGKSNIVDAICFVLGGKAAKLRRGSLLFLAGGGVKAGINSaSVEIT 78
|
90
....*....|...
gi 447170203 84 FQlkgKRYEIKRQ 96
Cdd:cd03239 79 FD---KSYFLVLQ 88
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
541-865 |
9.36e-06 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 50.06 E-value: 9.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 541 EKELNDLRDKKNIAEK---LNVQVEE-KWNFYRLQYEQVIEEVvkrgynsEKLAETYSALVQKGKQLAADVNTLKAS-EE 615
Cdd:TIGR02168 199 ERQLKSLERQAEKAERykeLKAELRElELALLVLRLEELREEL-------EELQEELKEAEEELEELTAELQELEEKlEE 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 616 TRKQIAvnmkSVEEKIEELQKQKREVETMQHRTEMECMQLRTSYEHDKRNIPENLQTVQAWKAQLDQAMQELRLMEDEWK 695
Cdd:TIGR02168 272 LRLEVS----ELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLE 347
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 696 KVQEAYQHWQNENIRIQAEQKGASNQFESAKlKKEETFARFMKELEQsgftdqftykEAKLSDAQMEMLQKEIQGYYSSL 775
Cdd:TIGR02168 348 ELKEELESLEAELEELEAELEELESRLEELE-EQLETLRSKVAQLEL----------QIASLNNEIERLEARLERLEDRR 416
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 776 EVLAKQIEELNSELKDKEYMDitsLGEHIKELEINLDIIKEKRQRAQNAVTYISDLHENIRRIDEQIHDEEKAFQELVDL 855
Cdd:TIGR02168 417 ERLQQEIEELLKKLEEAELKE---LQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDS 493
|
330
....*....|
gi 447170203 856 YEVMKGDNES 865
Cdd:TIGR02168 494 LERLQENLEG 503
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
33-863 |
1.06e-05 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 49.66 E-value: 1.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 33 ISGNTGAGKTTIFDAICYVLYGEASGEERSDTSMLRSQFADD-NVYTSVELTFQ-LKGKRYEIKRQL----GHKKQGNKT 106
Cdd:TIGR00606 33 LVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVAQEtDVRAQIRLQFRdVNGEECAVVRSMvctqKTKKTEFKT 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 107 ITGHAVELYeviDGENVPAVDRfhVTDVNKKMEDLIGLSKHQFSQIVMLPQGEFRKLLTSETENKEEiLRRIFKTDRYKL 186
Cdd:TIGR00606 113 LEGVITRYK---HGEKVSLSSK--CAEIDREMISHLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQK-FDEIFSATRYIK 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 187 MRELLDQKRKQWKDVLQEKQKERELYFRNVFKLP-IRDgalleTLVAQEH--VNTHQVVEVLEQETTVYKAEVEQLQ--- 260
Cdd:TIGR00606 187 ALETLRQVRQTQGQKVQEHQMELKYLKQYKEKACeIRD-----QITSKEAqlESSREIVKSYENELDPLKNRLKEIEhnl 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 261 ---VEQDVQTKQLKDAETRFHAAKSVNEKFID--LQQKNEKYNTLQENRAAiEGKEKSFKRAEQAKRLLPFEQwyEEAMQ 335
Cdd:TIGR00606 262 skiMKLDNEIKALKSRKKQMEKDNSELELKMEkvFQGTDEQLNDLYHNHQR-TVREKERELVDCQRELEKLNK--ERRLL 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 336 NEQKAESLLK------QIIVKQEQIM--------NSFELAQEKYEVVKNKELEREEAKKLVQRLEELQA--IIESLAERK 399
Cdd:TIGR00606 339 NQEKTELLVEqgrlqlQADRHQEHIRardsliqsLATRLELDGFERGPFSERQIKNFHTLVIERQEDEAktAAQLCADLQ 418
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 400 LNLQNAEIQIGKLKESMQKLDQQLEEHT-----------------SQKQGMSDELQQLEQALEQYVA------------- 449
Cdd:TIGR00606 419 SKERLKQEQADEIRDEKKGLGRTIELKKeilekkqeelkfvikelQQLEGSSDRILELDQELRKAERelskaeknsltet 498
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 450 -KVEELTNMREDAKVLKQAYDVWQEKQKFEQEKEA-------ANNKMQVAVRAYENMERRW------------------- 502
Cdd:TIGR00606 499 lKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTrtqmemlTKDKMDKDEQIRKIKSRHSdeltsllgyfpnkkqledw 578
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 503 ---LSEQAGILALHLHDGESCPVCGSTNHPQ------KATEQSNAIDEK------------ELNDLRDKKNIAEKLNVQV 561
Cdd:TIGR00606 579 lhsKSKEINQTRDRLAKLNKELASLEQNKNHinneleSKEEQLSSYEDKlfdvcgsqdeesDLERLKEEIEKSSKQRAML 658
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 562 EEKWNFYRLQYEQVIEE------VVKRGYNSEKLAETYSALVQKGKQLAADvntlkASEETRKQIAVNMKSVEEKIEELQ 635
Cdd:TIGR00606 659 AGATAVYSQFITQLTDEnqsccpVCQRVFQTEAELQEFISDLQSKLRLAPD-----KLKSTESELKKKEKRRDEMLGLAP 733
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 636 KQKREVEtmqhRTEMECMQLRTSYEHDKRNIPENLQTVQAWKAQLDQAMQELRLMEDEWKKVQ--EAYQHWQNENIRIQA 713
Cdd:TIGR00606 734 GRQSIID----LKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTimERFQMELKDVERKIA 809
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 714 EQKGASN---------QFESAKLKKEETFARFMKELEQ-----SGFTDQFTYKEAKLSDAQMEMLQ-----KEIQGYYSS 774
Cdd:TIGR00606 810 QQAAKLQgsdldrtvqQVNQEKQEKQHELDTVVSKIELnrkliQDQQEQIQHLKSKTNELKSEKLQigtnlQRRQQFEEQ 889
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 775 LEVLAKQIEELNSELKDKEYMDITSLGEHIKELEINLDIIKEKRQRAQNAVTYISDLHENIRRIDEQIHDEEKAFQELVD 854
Cdd:TIGR00606 890 LVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKD 969
|
....*....
gi 447170203 855 LYEVMKGDN 863
Cdd:TIGR00606 970 DYLKQKETE 978
|
|
| DNA_S_dndD |
TIGR03185 |
DNA sulfur modification protein DndD; This model describes the DndB protein encoded by an ... |
5-467 |
1.99e-05 |
|
DNA sulfur modification protein DndD; This model describes the DndB protein encoded by an operon associated with a sulfur-containing modification to DNA. The operon is sporadically distributed in bacteria, much like some restriction enzyme operons. DndD is described as a putative ATPase. The small number of examples known so far include species from among the Firmicutes, Actinomycetes, Proteobacteria, and Cyanobacteria. [DNA metabolism, Restriction/modification]
Pssm-ID: 274475 [Multi-domain] Cd Length: 650 Bit Score: 48.53 E-value: 1.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 5 QLIMTAFGPYKQKEVIDFEDLGEHRIFAISGNTGAGKTTIFDAICYVLYG-EASGEERSD-------TSMLRSQFADDNV 76
Cdd:TIGR03185 5 QLTLENFGPYRGRQTFDLSPSSPKPIILIGGLNGAGKTTLLDAIQLALYGkRALCSGRGNksyeqylRGLINRQAGKTNP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 77 yTSVELTFQL----KGKRYEIKRQLgHKKqgNKTItGHAVELYevidgenvpaVDRFHVTDVNKKMEDLI-GLSKHQFSQ 151
Cdd:TIGR03185 85 -ASITLTFSVveggKRHEYTLVRSW-HIN--NKDV-KEKLTVY----------KDDEEDDSLNDIWDEFInELLPLELAD 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 152 IVMLpQGEFRKLLTSETENKEEILRRIFKTdrykLMRELLDQKRKQWKDVLQEKQKErelyfrnvfKLPIRDGALLETLV 231
Cdd:TIGR03185 150 LFFF-DGEKIEALANPDRLASLLKEAIEVL----LGLDLIDRLAGDLTNVLRRRKKS---------ELPSSILSEIEALE 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 232 AQEHVNTHQvVEVLEQETTVYKAEVEQLQ-----VEQDVQTKQLKDAETRFHAAKSVNEKFIDLQQKNEKYNTLQE---- 302
Cdd:TIGR03185 216 AELKEQSEK-YEDLAQEIAHLRNELEEAQrslesLEKKFRSEGGDLFEEREQLERQLKEIEAARKANRAQLRELAAdplp 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 303 ---NRAAIEGKEKSFKRAEQAKR-------LLPFEQWYEEAMQNEQKAESLLKQIivkQEQIMNSFELAQEKYEV----- 367
Cdd:TIGR03185 295 lllIPNLLDSTKAQLQKEEQSQQnqltqeeLEERDKELLESLPKLALPAEHVKEI---AAELAEIDKPATTDSEIphrls 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 368 --------VKNKELEREEAKKLVQRLEELQAIIESLAERKLNLQN--AEIQIGKLKESMQKLDQQLEEHTSQKQGMSDEL 437
Cdd:TIGR03185 372 gseltqleVLIQQVKRELQDAKSQLLKELRELEEELAEVDKKISTipSEEQIAQLLEELGEAQNELFRSEAEIEELLRQL 451
|
490 500 510
....*....|....*....|....*....|
gi 447170203 438 QQLEQALEQYVAKVEELTNMREDAKVLKQA 467
Cdd:TIGR03185 452 ETLKEAIEALRKTLDEKTKQKINAFELERA 481
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
251-706 |
4.83e-05 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 47.83 E-value: 4.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 251 VYKAEVEQLQVEQDVQ-TKQLKDAETRFHAAKSVNEKFIDLQQKNEKYNTLQENRAAIEGKeksfKRAEQAKRLLPFEQW 329
Cdd:PTZ00121 1390 KKKADEAKKKAEEDKKkADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAK----KKAEEAKKAEEAKKK 1465
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 330 YEEAmqneQKAESLLKQI--IVKQEQIMNSFELAQEKYEVVKNKELEREEAKKLVQRLEELQAIIESLAERKLNLQnaEI 407
Cdd:PTZ00121 1466 AEEA----KKADEAKKKAeeAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKAD--EA 1539
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 408 QIGKLKESMQKLDQQLEEHTSQKQGMSDELQQLEQALEQYVAKVEELTNMREDAKVLKQAYDVWQEKQKFEQEKEAANNK 487
Cdd:PTZ00121 1540 KKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAK 1619
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 488 MQVAVRAYENMERRWLSEQAGILALHLHDGESCpvcgstnhpQKATEQSNAIDEKELNDLRDKKNIAEKLNVQVEEkwnf 567
Cdd:PTZ00121 1620 IKAEELKKAEEEKKKVEQLKKKEAEEKKKAEEL---------KKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEED---- 1686
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 568 yrlqyEQVIEEVVKRGYNSEKLAEtysalvQKGKQLAADVntlKASEETRKQIAVNMKSVEEKIEELQKQKREVETMQHR 647
Cdd:PTZ00121 1687 -----EKKAAEALKKEAEEAKKAE------ELKKKEAEEK---KKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKD 1752
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 447170203 648 TEMECMQLRTSYEHDKRNIPENLQTVQAWKAQLDQAmQELRLMEDEwKKVQEAYQHWQN 706
Cdd:PTZ00121 1753 EEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEE-DEKRRMEVD-KKIKDIFDNFAN 1809
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
372-1016 |
4.83e-05 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 47.34 E-value: 4.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 372 ELEREEAKK--LVQRLEELQAIIESLAERKLNLQNAEIQIGKLKESMQKLDQQLEEHTSQKQGMSDELQQLEQALEQYVA 449
Cdd:PRK02224 221 EIERYEEQReqARETRDEADEVLEEHEERREELETLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLA 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 450 KVEeltnmREDAkvlkQAYDVWQEKQKFEQEKEAANNK-MQVAVRAYEnmerrwLSEQAGILALHLHDGEScpvcGSTNH 528
Cdd:PRK02224 301 EAG-----LDDA----DAEAVEARREELEDRDEELRDRlEECRVAAQA------HNEEAESLREDADDLEE----RAEEL 361
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 529 PQKATEQSNAIDEKElNDLRDKKNIAEKLNVQVEEKwnfyRLQYEQVIEEVVKRGYNSEKLAETYSALVQKGKQLAADVN 608
Cdd:PRK02224 362 REEAAELESELEEAR-EAVEDRREEIEELEEEIEEL----RERFGDAPVDLGNAEDFLEELREERDELREREAELEATLR 436
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 609 TL-KASEETRK-----------------QIAVNMKSVEEKIEELQKQKREVETMQHRTEMECMQLRTSYEHDKR--NIPE 668
Cdd:PRK02224 437 TArERVEEAEAlleagkcpecgqpvegsPHVETIEEDRERVEELEAELEDLEEEVEEVEERLERAEDLVEAEDRieRLEE 516
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 669 NLQTVQAWKAQLDQAMQELRLMEDEWKKvqeayqhwQNENIRIQAEQK--GASNQFESAKLKKEETfarfmKELEQsgft 746
Cdd:PRK02224 517 RREDLEELIAERRETIEEKRERAEELRE--------RAAELEAEAEEKreAAAEAEEEAEEAREEV-----AELNS---- 579
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 747 DQFTYKEAKLSDAQMEMLQKEIQGYYSSLEVLA---KQIEELNSELKDKeymdITSLGEHIKELEINLD--IIKEKRQRA 821
Cdd:PRK02224 580 KLAELKERIESLERIRTLLAAIADAEDEIERLRekrEALAELNDERRER----LAEKRERKRELEAEFDeaRIEEAREDK 655
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 822 QNAVTYISDLHENIRRIDEQ-------IHDEEKAFQELVDLYEVMKGDNESRISFER-YILIEYLE--------QIVQIA 885
Cdd:PRK02224 656 ERAEEYLEQVEEKLDELREErddlqaeIGAVENELEELEELRERREALENRVEALEAlYDEAEELEsmygdlraELRQRN 735
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 886 NERLRKLSNGQFYLkrserVEKRNRQSGLGLD------VYDAyTGQTRDVKTLSGGEK--FNASL-C-----LALGMadv 951
Cdd:PRK02224 736 VETLERMLNETFDL-----VYQNDAYSHIELDgeyeltVYQK-DGEPLEPEQLSGGERalFNLSLrCaiyrlLAEGI--- 806
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447170203 952 iqayEGGISIETMFIDEGFGSLDEESLTKAVDALIDLQKSG-RFIGVISHVQELKNAMPAVLEVTK 1016
Cdd:PRK02224 807 ----EGDAPLPPLILDEPTVFLDSGHVSQLVDLVESMRRLGvEQIVVVSHDDELVGAADDLVRVEK 868
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
164-805 |
6.00e-05 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 47.42 E-value: 6.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 164 LTSETENKEEILRRIFKTDRYKLMREL------LDQKRKQWKDVLQEKQKERELY---FRNVFKLPIRDGALLETLVAQe 234
Cdd:pfam15921 250 LKSESQNKIELLLQQHQDRIEQLISEHeveitgLTEKASSARSQANSIQSQLEIIqeqARNQNSMYMRQLSDLESTVSQ- 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 235 hvnthqVVEVLEQETTVYKAEVEQLQveqdvqtKQLKDAETRFHAAKSVNEKFIdlQQKNEKYNTLQENRAAIEGKEKSF 314
Cdd:pfam15921 329 ------LRSELREAKRMYEDKIEELE-------KQLVLANSELTEARTERDQFS--QESGNLDDQLQKLLADLHKREKEL 393
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 315 K-RAEQAKRLLP-----------FEQWYEEAMQNEQKAESLLKQIIV----KQEQIMNSFELAQEKYEVVKNKELEREEA 378
Cdd:pfam15921 394 SlEKEQNKRLWDrdtgnsitidhLRRELDDRNMEVQRLEALLKAMKSecqgQMERQMAAIQGKNESLEKVSSLTAQLEST 473
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 379 KklvqrlEELQAIIESLAERKLNLQNAEIQIGKLKESMQKLDQQLEEHTSQKQGMSDELQQLEQALEQYVAKVEELTNMR 458
Cdd:pfam15921 474 K------EMLRKVVEELTAKKMTLESSERTVSDLTASLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQ 547
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 459 EDAKVLK---------------QAYDVWQ------------EKQKFEQEKEAANNKMQVA----VRAYENMERRWLSEQA 507
Cdd:pfam15921 548 TECEALKlqmaekdkvieilrqQIENMTQlvgqhgrtagamQVEKAQLEKEINDRRLELQefkiLKDKKDAKIRELEARV 627
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 508 GILALhlhdgESCPVCGSTNHPQKATEQSNAIDEKELNDLRDKKNiaeKLNVQVEEKwnfyrlqyeqvieEVVKRGY--N 585
Cdd:pfam15921 628 SDLEL-----EKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRN---ELNSLSEDY-------------EVLKRNFrnK 686
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 586 SEKLAETYSALVQKGKQLAADV----NTLKASEET---RKQIAVNMKsveekiEELQKQKREVETMQHRTEM--ECMQLR 656
Cdd:pfam15921 687 SEEMETTTNKLKMQLKSAQSELeqtrNTLKSMEGSdghAMKVAMGMQ------KQITAKRGQIDALQSKIQFleEAMTNA 760
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 657 TSYEH----DKRNIPENLQTVQAWKAQLDQAMQELRLMEDEWKKV---------QEAYQHWQNENIRIQAEQkgasnqfE 723
Cdd:pfam15921 761 NKEKHflkeEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKEKvanmevaldKASLQFAECQDIIQRQEQ-------E 833
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 724 SAKLKKEETFArfMKELEQSGFTDQFTYKEAKLSDAQMEMLQKEIQGYYSSLEVLAKQIEELNSeLKDKEYMDITSLGEH 803
Cdd:pfam15921 834 SVRLKLQHTLD--VKELQGPGYTSNSSMKPRLLQPASFTRTHSNVPSSQSTASFLSHHSRKTNA-LKEDPTRDLKQLLQE 910
|
..
gi 447170203 804 IK 805
Cdd:pfam15921 911 LR 912
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
253-486 |
6.58e-05 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 46.30 E-value: 6.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 253 KAEVEQLQVEQDVQTKQLKDAETRFHAAKSvnekfiDLQQKNEKYNTLQENRAAIEGKeksfkRAEQAKRLLPFEQWYEE 332
Cdd:COG4942 26 EAELEQLQQEIAELEKELAALKKEEKALLK------QLAALERRIAALARRIRALEQE-----LAALEAELAELEKEIAE 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 333 AMQNEQKAESLLKQIIVKQEQIMNSFEL-----AQEKYEVVKNKELEREEAKKLVQRLEELQAIIESLAERKLNLQNAEI 407
Cdd:COG4942 95 LRAELEAQKEELAELLRALYRLGRQPPLalllsPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERA 174
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447170203 408 QIGKLKESMQKLDQQLEEHTSQKQGMSDELQQLEQALEQyvakveELTNMREDAKVLKQAYDVWQEKQKFEQEKEAANN 486
Cdd:COG4942 175 ELEALLAELEEERAALEALKAERQKLLARLEKELAELAA------ELAELQQEAEELEALIARLEAEAAAAAERTPAAG 247
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
339-776 |
7.00e-05 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 46.96 E-value: 7.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 339 KAESLLKQIIVKQEQIMNSFELAQEKYE-VVKNKELEREEAKKLVQ-RLEELQAIIESLAERKLNLQNAEIQIGKLKESM 416
Cdd:TIGR00606 688 QTEAELQEFISDLQSKLRLAPDKLKSTEsELKKKEKRRDEMLGLAPgRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDI 767
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 417 QKLDQQLEEhTSQKQGMSDELQQLEQALEQYVAKVEELTNMREDAKVLKQAYDVWQEKQKFEQEKEAANNKMQVAVRAYE 496
Cdd:TIGR00606 768 EEQETLLGT-IMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGSDLDRTVQQVNQEKQEKQHELDTVVSKIE 846
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 497 NMERRWLSEQAGILALH--LHDGESCPVCGSTNHPQK-ATEQSNAIDEKELNDLrdKKNIAEKLNVQVEEKWNFYRLQYE 573
Cdd:TIGR00606 847 LNRKLIQDQQEQIQHLKskTNELKSEKLQIGTNLQRRqQFEEQLVELSTEVQSL--IREIKDAKEQDSPLETFLEKDQQE 924
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 574 QviEEVVKRGYNSEKLAETYSALVQK------GKQLAADVNTLKASEETRKQIAVNMKSVEEKIEELQKQKREVET--MQ 645
Cdd:TIGR00606 925 K--EELISSKETSNKKAQDKVNDIKEkvknihGYMKDIENKIQDGKDDYLKQKETELNTVNAQLEECEKHQEKINEdmRL 1002
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 646 HRTEMECMQLRTSYEHDK---RNIPENLQTVQAWKAQLDQAMQELRL--MEDEWKKVQEAYQHWQNENIRIQAEQKGAsn 720
Cdd:TIGR00606 1003 MRQDIDTQKIQERWLQDNltlRKRENELKEVEEELKQHLKEMGQMQVlqMKQEHQKLEENIDLIKRNHVLALGRQKGY-- 1080
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 447170203 721 qfesaklkkEETFARFMKELEQSGFTD-QFTYKEAKLSDAQMEMLQKEIQGYYSSLE 776
Cdd:TIGR00606 1081 ---------EKEIKHFKKELREPQFRDaEEKYREMMIVMRTTELVNKDLDIYYKTLD 1128
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
359-700 |
1.70e-04 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 45.72 E-value: 1.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 359 ELAQEKYEVVKNKELE-------REEAKKLVQRLEELQAIIESLAERkLNL-QNAEIQ---IGKLKESMQKLDQQLEEHT 427
Cdd:PRK04863 290 ELRRELYTSRRQLAAEqyrlvemARELAELNEAESDLEQDYQAASDH-LNLvQTALRQqekIERYQADLEELEERLEEQN 368
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 428 SQKQGMSDELQQLEQALEQYVAKVEELTNMREDakvLKQAYDVwqekqkfeQEKEAAnnKMQVAVRAYENMErrwlsEQA 507
Cdd:PRK04863 369 EVVEEADEQQEENEARAEAAEEEVDELKSQLAD---YQQALDV--------QQTRAI--QYQQAVQALERAK-----QLC 430
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 508 GILALHLHDGEScpvcgstnHPQKATEQSNAIDEkELNDLRDKKNIAEKLNVQVEEKWNFY--------RLQYEQVIEEV 579
Cdd:PRK04863 431 GLPDLTADNAED--------WLEEFQAKEQEATE-ELLSLEQKLSVAQAAHSQFEQAYQLVrkiagevsRSEAWDVAREL 501
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 580 VKRGYNSEKLAETYSALVQKGKQLAADVNTLKASEETRKQIAVNMKSVEEKIEELQKQKREVEtmqhrtemecmQLRTSY 659
Cdd:PRK04863 502 LRRLREQRHLAEQLQQLRMRLSELEQRLRQQQRAERLLAEFCKRLGKNLDDEDELEQLQEELE-----------ARLESL 570
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 447170203 660 EHDKRNIPENLQTVQAWKAQLDQAMQELRLMEDEWKKVQEA 700
Cdd:PRK04863 571 SESVSEARERRMALRQQLEQLQARIQRLAARAPAWLAAQDA 611
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
225-467 |
3.54e-04 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 44.62 E-value: 3.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 225 ALLETLVAQEHVNTHQVVEVLEQETTVYKAEVEQLQ--VEQDVQTKQLKDAETRfhaAKSVNEKFIDLQQKnekYNTLQE 302
Cdd:COG3206 160 AYLEQNLELRREEARKALEFLEEQLPELRKELEEAEaaLEEFRQKNGLVDLSEE---AKLLLQQLSELESQ---LAEARA 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 303 NRAAIEGkeksfkRAEQAKRLLPFEQWYEEAMQNEQKAESLLKQIIVKQEQIMNSFELAQEKYEVVKNKELEREEAKKLV 382
Cdd:COG3206 234 ELAEAEA------RLAALRAQLGSGPDALPELLQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQL 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 383 QrlEELQAIIESLaerKLNLQNAEIQIGKLKESMQKLDQQLEEhTSQKQgmsDELQQLEQALEQYVAKVEELTNMREDAK 462
Cdd:COG3206 308 Q--QEAQRILASL---EAELEALQAREASLQAQLAQLEARLAE-LPELE---AELRRLEREVEVARELYESLLQRLEEAR 378
|
....*
gi 447170203 463 VLKQA 467
Cdd:COG3206 379 LAEAL 383
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
33-642 |
3.94e-04 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 44.67 E-value: 3.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 33 ISGNTGAGKTTIFDAICYVLYGeasGEERSDTSMLRSQFADDNVY-TSVELTFQLKGKRYEIKRQLghkKQGNKTITGHA 111
Cdd:PRK03918 28 IIGQNGSGKSSILEAILVGLYW---GHGSKPKGLKKDDFTRIGGSgTEIELKFEKNGRKYRIVRSF---NRGESYLKYLD 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 112 VELYEVIDGENVPAVdrfhvtdvnkkMEDLIGLskHQFSQIVMLPQGEFRKLLTSEtENKEEILRRIFKTDRY------- 184
Cdd:PRK03918 102 GSEVLEEGDSSVREW-----------VERLIPY--HVFLNAIYIRQGEIDAILESD-ESREKVVRQILGLDDYenayknl 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 185 KLMRELLDQKRKQWKDVLQ----------EKQKERELYFRNVFKLPIRDGALLETLVA-----QEHVNTHQVVEVLEQET 249
Cdd:PRK03918 168 GEVIKEIKRRIERLEKFIKrtenieelikEKEKELEEVLREINEISSELPELREELEKlekevKELEELKEEIEELEKEL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 250 TVYKAEVEQLQV----------EQDVQTKQLKDAETRFHAAKSVNEKFIDLQQKNEKYN--------TLQENRAAIEGKE 311
Cdd:PRK03918 248 ESLEGSKRKLEEkireleerieELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEEYLdelreiekRLSRLEEEINGIE 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 312 KSFKRAEQAK------------------RLLPFEQWYEEAMQNEQKAESLlkqiivKQEQIMNSFELAQEKYEVVKNKEL 373
Cdd:PRK03918 328 ERIKELEEKEerleelkkklkelekrleELEERHELYEEAKAKKEELERL------KKRLTGLTPEKLEKELEELEKAKE 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 374 E-REEAKKLVQRLEELQAIIESL------------------------------AERKLNLQNAEIQIGKLKESMQKLDQQ 422
Cdd:PRK03918 402 EiEEEISKITARIGELKKEIKELkkaieelkkakgkcpvcgrelteehrkellEEYTAELKRIEKELKEIEEKERKLRKE 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 423 L---------EEHTSQKQGMSDELQQLEQALEQYV-----AKVEELTNMREDAKVLKQAYDVW----QEKQKFEQEKEAA 484
Cdd:PRK03918 482 LrelekvlkkESELIKLKELAEQLKELEEKLKKYNleeleKKAEEYEKLKEKLIKLKGEIKSLkkelEKLEELKKKLAEL 561
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 485 NNKMQVAVRAYENMERRWLSEQAG-ILALHLHDGESCPVCGSTNHPQKAtEQSNAIDEKELNDLRDKKNIAEKLNVQVEE 563
Cdd:PRK03918 562 EKKLDELEEELAELLKELEELGFEsVEELEERLKELEPFYNEYLELKDA-EKELEREEKELKKLEEELDKAFEELAETEK 640
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447170203 564 KWNFYRLQYEQVieevvKRGYNSEKLAETYSALVQKGKQLAADVNTLKASEETRKQIAVNMKSVEEKIEELQKQKREVE 642
Cdd:PRK03918 641 RLEELRKELEEL-----EKKYSEEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKELE 714
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
240-475 |
4.35e-04 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 44.56 E-value: 4.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 240 QVVEVLEQETTVYKAEVEQLQVEQDVQTKQLKDAETRFhaaksvnekfiDLQQKnekyNTLQENRAaiegkeksfKRA-E 318
Cdd:PRK04863 369 EVVEEADEQQEENEARAEAAEEEVDELKSQLADYQQAL-----------DVQQT----RAIQYQQA---------VQAlE 424
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 319 QAKRLLP--------FEQWYEEAMQNEQKAESLLKQIivkqEQIMNSFELAQEKYEVVKN------KELEREEA----KK 380
Cdd:PRK04863 425 RAKQLCGlpdltadnAEDWLEEFQAKEQEATEELLSL----EQKLSVAQAAHSQFEQAYQlvrkiaGEVSRSEAwdvaRE 500
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 381 LVQRLEELQAIIESL---------AERKLNLQNAEIQIgkLKESMQKLDQQ------LEEHTSQKQGMSDEL-QQLEQAL 444
Cdd:PRK04863 501 LLRRLREQRHLAEQLqqlrmrlseLEQRLRQQQRAERL--LAEFCKRLGKNlddedeLEQLQEELEARLESLsESVSEAR 578
|
250 260 270
....*....|....*....|....*....|.
gi 447170203 445 EQYVAKVEELTNMREDAKVLKQAYDVWQEKQ 475
Cdd:PRK04863 579 ERRMALRQQLEQLQARIQRLAARAPAWLAAQ 609
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
375-655 |
5.16e-04 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 44.18 E-value: 5.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 375 REEAKKLVQRLEELQAIIESLAERKLNLQN----AEIQIGKLKESM----QKLDQQ-------------LEEHTSQKQGM 433
Cdd:PRK04863 354 QADLEELEERLEEQNEVVEEADEQQEENEAraeaAEEEVDELKSQLadyqQALDVQqtraiqyqqavqaLERAKQLCGLP 433
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 434 SDELQQLEQALEQYVAKVEELTNMREDakvLKQAYDVWQE-KQKFEQ------------EKEAANNKMQVAVRAYEnmER 500
Cdd:PRK04863 434 DLTADNAEDWLEEFQAKEQEATEELLS---LEQKLSVAQAaHSQFEQayqlvrkiagevSRSEAWDVARELLRRLR--EQ 508
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 501 RWLSEQAGILALHLHDGEscpvcgstnhpQKATEQSNAidekelNDLRDKKNIAEKLNVQVEEKWNFYRLQYEQVIEEVv 580
Cdd:PRK04863 509 RHLAEQLQQLRMRLSELE-----------QRLRQQQRA------ERLLAEFCKRLGKNLDDEDELEQLQEELEARLESL- 570
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 581 krGYNSEKLAETYSALVQKGKQLAADVNTLKASE---------------------ETRKQIAVNMKSVEEKIEELQKQKR 639
Cdd:PRK04863 571 --SESVSEARERRMALRQQLEQLQARIQRLAARApawlaaqdalarlreqsgeefEDSQDVTEYMQQLLERERELTVERD 648
|
330
....*....|....*.
gi 447170203 640 EVETMQHRTEMECMQL 655
Cdd:PRK04863 649 ELAARKQALDEEIERL 664
|
|
| AAA_29 |
pfam13555 |
P-loop containing region of AAA domain; |
24-60 |
5.62e-04 |
|
P-loop containing region of AAA domain;
Pssm-ID: 433304 [Multi-domain] Cd Length: 61 Bit Score: 39.12 E-value: 5.62e-04
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 447170203 24 DLGEHRIFAISGNTGAGKTTIFDAICYVLYG-------EASGEE 60
Cdd:pfam13555 18 PIDPRGNTLLTGPSGSGKSTLLDAIQTLLVPakrarfnKAANAG 61
|
|
| CALCOCO1 |
pfam07888 |
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ... |
290-507 |
5.79e-04 |
|
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.
Pssm-ID: 462303 [Multi-domain] Cd Length: 488 Bit Score: 43.73 E-value: 5.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 290 LQQKNEkynTLQENRAAIEGKEKSFKRAEQAKrlLPFEQWYEEAMQNEQKAESLLKQIIVKQEQIMNSF-ELAQEKYEVV 368
Cdd:pfam07888 40 LQERAE---LLQAQEAANRQREKEKERYKRDR--EQWERQRRELESRVAELKEELRQSREKHEELEEKYkELSASSEELS 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 369 KNKELEREEAKKLVQRLEELQAIIESLAERKLNlqnAEIQIGKLKESMQKLDQQLEEHTSQKQGMSDELQQLEQALEQYV 448
Cdd:pfam07888 115 EEKDALLAQRAAHEARIRELEEDIKTLTQRVLE---RETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELRSLS 191
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447170203 449 AKVEELTNMRE--DAKVLKQAYDVWQEKQKFE--QEKEAANNKMQVAVRAYEnmERRWLSEQA 507
Cdd:pfam07888 192 KEFQELRNSLAqrDTQVLQLQDTITTLTQKLTtaHRKEAENEALLEELRSLQ--ERLNASERK 252
|
|
| PRK12704 |
PRK12704 |
phosphodiesterase; Provisional |
337-462 |
7.19e-04 |
|
phosphodiesterase; Provisional
Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 43.23 E-value: 7.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 337 EQKAESLLKQIIVKQEQIMNSFEL-AQEKYEVVKNkELEREeakkLVQRLEELQAIIESLAERKLNLQNaeiQIGKLKES 415
Cdd:PRK12704 37 EEEAKRILEEAKKEAEAIKKEALLeAKEEIHKLRN-EFEKE----LRERRNELQKLEKRLLQKEENLDR---KLELLEKR 108
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 447170203 416 MQKLDQQLEEHTSQKQGMSDELQQLEQALEQYVAKVEELTNM-REDAK 462
Cdd:PRK12704 109 EEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERISGLtAEEAK 156
|
|
| DUF3584 |
pfam12128 |
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ... |
372-687 |
7.38e-04 |
|
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.
Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 43.67 E-value: 7.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 372 ELEREEAKKLVQRLEELQAIIESLAERKLNLQNAEIQIGKLKESMQ----KLDQQLEEHTSQKQGMSDELQQLEQALEQY 447
Cdd:pfam12128 237 MKIRPEFTKLQQEFNTLESAELRLSHLHFGYKSDETLIASRQEERQetsaELNQLLRTLDDQWKEKRDELNGELSAADAA 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 448 VAKVEELTNMREDAKVLKQAYDVWQEKQKFEQEKEAANNkmqvavraYENMERRwlseqagilaLHLHDGESCPVCGSTN 527
Cdd:pfam12128 317 VAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSE--------LENLEER----------LKALTGKHQDVTAKYN 378
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 528 HPQKATEQSNAIDEKELNDLRDkkNIAEKLNVQVEEKWNFYRlQYEQVIEEVVKRGYNSEKLAEtySALVQKGKQLAADV 607
Cdd:pfam12128 379 RRRSKIKEQNNRDIAGIKDKLA--KIREARDRQLAVAEDDLQ-ALESELREQLEAGKLEFNEEE--YRLKSRLGELKLRL 453
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 608 NTLKASEETRKQIAVNMKSVEEKIEELQKQKREVETMQhrteMECMQLRTSYEHDKRNIPENLQTVQAWKAQLDQAMQEL 687
Cdd:pfam12128 454 NQATATPELLLQLENFDERIERAREEQEAANAEVERLQ----SELRQARKRRDQASEALRQASRRLEERQSALDELELQL 529
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
541-848 |
7.40e-04 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 43.77 E-value: 7.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 541 EKELNDLRDKKNIAEK---LNVQVEEKWNFYRLQYEQVIEEvvkrgyNSEKLAETYSALVQKGKQLAADVNTLKASEETR 617
Cdd:COG1196 199 ERQLEPLERQAEKAERyreLKEELKELEAELLLLKLRELEA------ELEELEAELEELEAELEELEAELAELEAELEEL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 618 KQiavNMKSVEEKIEELQKQKREVETMQHRTEMECMQLRTSYEHDKRNIPENLQTVQAWKAQLDQAMQELRLMEDEWKKV 697
Cdd:COG1196 273 RL---ELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEA 349
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 698 QEAYQHWQNENIRIQAEQKGASNQFESAKLKKEETFARFMKEL-EQSGFTDQFTYKEAKLSDAQ--MEMLQKEIQGYYSS 774
Cdd:COG1196 350 EEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALrAAAELAAQLEELEEAEEALLerLERLEEELEELEEA 429
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447170203 775 LEVLAKQIEELNSELKDKEymdiTSLGEHIKELEINLDIIKEKRQRAQNAVTYISDLHENIRRIDEQIHDEEKA 848
Cdd:COG1196 430 LAELEEEEEEEEEALEEAA----EEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEA 499
|
|
| CCDC22 |
pfam05667 |
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ... |
677-874 |
1.10e-03 |
|
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.
Pssm-ID: 461708 [Multi-domain] Cd Length: 600 Bit Score: 42.71 E-value: 1.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 677 KAQLDQAMQELRLMEDEWKKVQEAYQHwqnenIRIQAEQKGASN-QFESAKLKKEETFarfmKELEQSgftdqftykeak 755
Cdd:pfam05667 341 QEQLEDLESSIQELEKEIKKLESSIKQ-----VEEELEELKEQNeELEKQYKVKKKTL----DLLPDA------------ 399
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 756 lsDAQMEMLQKEIQGYYSSLEVLAKQIEELNSELkdkeymditslgehIKELEINLDIIKEKRQRAQNAVTYISDLHENI 835
Cdd:pfam05667 400 --EENIAKLQALVDASAQRLVELAGQWEKHRVPL--------------IEEYRALKEAKSNKEDESQRKLEEIKELREKI 463
|
170 180 190
....*....|....*....|....*....|....*....
gi 447170203 836 RRIDEQIHDEEKAFQELVDLYEVMKGDnESRISFERYIL 874
Cdd:pfam05667 464 KEVAEEAKQKEELYKQLVAEYERLPKD-VSRSAYTRRIL 501
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
229-860 |
1.13e-03 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 43.21 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 229 TLVAQEHVNTHQVVEVLEQETTVYKAEVEQLQVEQDVQTKQLKDA-ETRFHAAKSVNE-KFIDLQQKNEKYNTLQENRAA 306
Cdd:PTZ00121 1011 TALTANTIDFNQNFNIEKIEELTEYGNNDDVLKEKDIIDEDIDGNhEGKAEAKAHVGQdEGLKPSYKDFDFDAKEDNRAD 1090
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 307 iEGKEKSFKRAEQAKRllpfeqwyEEAMQNEQKAesllkqiivKQEQIMNSFELAQEKYEVVKNKELEREEAKKLVQRLE 386
Cdd:PTZ00121 1091 -EATEEAFGKAEEAKK--------TETGKAEEAR---------KAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAK 1152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 387 ELQAIIESLAERKLNLQNAEIQIGKLKESMQKLDQQLEEHTSQkqgmSDELQQLEQALEQYVAKVEELTNMREDAKVLKQ 466
Cdd:PTZ00121 1153 RVEIARKAEDARKAEEARKAEDAKKAEAARKAEEVRKAEELRK----AEDARKAEAARKAEEERKAEEARKAEDAKKAEA 1228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 467 AYDVWQEKQKFEQEKEAANNKMQVAVRAYEnmERRWLSEQAGILALHLHDGESCPVCGSTNHPQKATEQSNAIDEKELND 546
Cdd:PTZ00121 1229 VKKAEEAKKDAEEAKKAEEERNNEEIRKFE--EARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADE 1306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 547 LRDK---KNIAEKLNVQVEEKwnfyrlqyEQVIEEVVKRGYNSEKLAETYSALVQKGKqlaadvNTLKASEETRKQIAVN 623
Cdd:PTZ00121 1307 AKKKaeeAKKADEAKKKAEEA--------KKKADAAKKKAEEAKKAAEAAKAEAEAAA------DEAEAAEEKAEAAEKK 1372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 624 MKSVEEKIEELQKQKREVETMQhrtemecmQLRTSYEHDKRNiPENLQTVQAWKAQLDQA---MQELRLMEDEWKKVQEA 700
Cdd:PTZ00121 1373 KEEAKKKADAAKKKAEEKKKAD--------EAKKKAEEDKKK-ADELKKAAAAKKKADEAkkkAEEKKKADEAKKKAEEA 1443
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 701 YQhwQNENIRIQAEQKGASNQFESAKLKKEETFARfmKELEQSGFTDQFTyKEAKLSDAQMEMLQKEIQGYYSSLEVL-- 778
Cdd:PTZ00121 1444 KK--ADEAKKKAEEAKKAEEAKKKAEEAKKADEAK--KKAEEAKKADEAK-KKAEEAKKKADEAKKAAEAKKKADEAKka 1518
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 779 --AKQIEELNSELKDKEYMDITSLGEHIK--ELEINLDIIK-EKRQRAQNAVTYISDLHENIRRIDEQIHDEEKAFQELV 853
Cdd:PTZ00121 1519 eeAKKADEAKKAEEAKKADEAKKAEEKKKadELKKAEELKKaEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVM 1598
|
....*..
gi 447170203 854 DLYEVMK 860
Cdd:PTZ00121 1599 KLYEEEK 1605
|
|
| DUF3584 |
pfam12128 |
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ... |
167-744 |
1.14e-03 |
|
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.
Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 42.90 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 167 ETENKEEILRRIFKTdRYKLMRELLDQKRKQWKDVLQEKQKERELYFRNVFKLPIRDGALLETLVAQEHVNTHQVVEVLE 246
Cdd:pfam12128 269 SDETLIASRQEERQE-TSAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLDADIETAAADQE 347
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 247 QETTVyKAEVEQLQVEQDVQTKQLKDAETRFHAAKS-----VNEKFIDLQQKNEK-YNTLQENRAAIEG---KEKSFKRA 317
Cdd:pfam12128 348 QLPSW-QSELENLEERLKALTGKHQDVTAKYNRRRSkikeqNNRDIAGIKDKLAKiREARDRQLAVAEDdlqALESELRE 426
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 318 EQAKRLLPF---EQWYEEAMQNE-------QKAESLLKQIIVKQEQIMNSFELAQEKYEVVKNKELEREEAKKLV-QRLE 386
Cdd:pfam12128 427 QLEAGKLEFneeEYRLKSRLGELklrlnqaTATPELLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRdQASE 506
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 387 ELQAIIESLAERKLNLQNAEIQ----------------------IGKLKESMQ----KLDQQLEEHTSQKQ----GMSDE 436
Cdd:pfam12128 507 ALRQASRRLEERQSALDELELQlfpqagtllhflrkeapdweqsIGKVISPELlhrtDLDPEVWDGSVGGElnlyGVKLD 586
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 437 LQQLEqaLEQYVAKVEELtnmREDAKVLKQAYDVWQEKQKFEQEK--------EAANNKMQVAVRAYENME---RRWLSE 505
Cdd:pfam12128 587 LKRID--VPEWAASEEEL---RERLDKAEEALQSAREKQAAAEEQlvqangelEKASREETFARTALKNARldlRRLFDE 661
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 506 QAgilALHLHDGEScpvcgSTNHPQKATEQSNAIDEKELNDLRDKKNIAEKLNVQVEEKwNFYRLQYEQVIEEV--VKRG 583
Cdd:pfam12128 662 KQ---SEKDKKNKA-----LAERKDSANERLNSLEAQLKQLDKKHQAWLEEQKEQKREA-RTEKQAYWQVVEGAldAQLA 732
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 584 YNSEKLAETYSALVQKGKQL----AADVNTLKASEETRKQIAVNMKSVEEKIEE-------------------------L 634
Cdd:pfam12128 733 LLKAAIAARRSGAKAELKALetwyKRDLASLGVDPDVIAKLKREIRTLERKIERiavrrqevlryfdwyqetwlqrrprL 812
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 635 QKQKREVETMQHRTEMECMQLRTSYEHDKRNIPENLQtvqAWKAQLDQAMQELRLMEDEWKKVQEAYQHWQNENIRI--- 711
Cdd:pfam12128 813 ATQLSNIERAISELQQQLARLIADTKLRRAKLEMERK---ASEKQQVRLSENLRGLRCEMSKLATLKEDANSEQAQGsig 889
|
650 660 670
....*....|....*....|....*....|....*...
gi 447170203 712 ----QAEQKGASNQFESAKLKKE-ETFARFMKELEQSG 744
Cdd:pfam12128 890 erlaQLEDLKLKRDYLSESVKKYvEHFKNVIADHSGSG 927
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
254-485 |
1.14e-03 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 43.13 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 254 AEVEQLQVEQDVQTKQLKDAETRFHAAKSVNEKFIDLQQKNEKY------NTLQENRAAIEGKEKSFKRAEQAKrllpfE 327
Cdd:TIGR02169 180 EEVEENIERLDLIIDEKRQQLERLRREREKAERYQALLKEKREYegyellKEKEALERQKEAIERQLASLEEEL-----E 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 328 QWYEEAMQNEQKAESLLKQIIVKQEQIMnsfELAQEKYEVVKNKELERE-EAKKLVQRLEELQAIIESLAERklnLQNAE 406
Cdd:TIGR02169 255 KLTEEISELEKRLEEIEQLLEELNKKIK---DLGEEEQLRVKEKIGELEaEIASLERSIAEKERELEDAEER---LAKLE 328
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447170203 407 IQIGKLKESMQKLDQQLEEHTSQKQGMSDELQQLEQALEQYVAKVEELTnmrEDAKVLKQAYDvwQEKQKFEQEKEAAN 485
Cdd:TIGR02169 329 AEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVD---KEFAETRDELK--DYREKLEKLKREIN 402
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
374-733 |
1.64e-03 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 42.36 E-value: 1.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 374 EREEAKKLVQRLEELQAIIESLAERKLNLQNAeiqIGKLKESMQKLDQQLEEhtsqkqgMSDELQQLEQALEQYVAKVEE 453
Cdd:TIGR02169 672 EPAELQRLRERLEGLKRELSSLQSELRRIENR---LDELSQELSDASRKIGE-------IEKEIEQLEQEEEKLKERLEE 741
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 454 LTnmredakvlkqaydvwQEKQKFEQEKEAANNKMQVAVRAYENMERRWLSEQAGILALHLHDGEScPVCGSTNHPQKAT 533
Cdd:TIGR02169 742 LE----------------EDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHS-RIPEIQAELSKLE 804
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 534 EQSNAID------EKELNDLRDKKNIAEKLNVQVEEkwnfYRLQYEQVIEEVVKRGYNSEKLAEtysALVQKGKQLAADV 607
Cdd:TIGR02169 805 EEVSRIEarlreiEQKLNRLTLEKEYLEKEIQELQE----QRIDLKEQIKSIEKEIENLNGKKE---ELEEELEELEAAL 877
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 608 NTLkasEETRKQIAVNMKSVEEKIEELQKQKREVETMQHRTEMECMQLR----------TSYEHDKRN---IPENLQTVQ 674
Cdd:TIGR02169 878 RDL---ESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKaklealeeelSEIEDPKGEdeeIPEEELSLE 954
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 447170203 675 AWKAQLDQAMQELRLME-------DEWKKVQEAYQHWQNENIRIQAEQKGASNQFESAKLKKEETF 733
Cdd:TIGR02169 955 DVQAELQRVEEEIRALEpvnmlaiQEYEEVLKRLDELKEKRAKLEEERKAILERIEEYEKKKREVF 1020
|
|
| Nup88 |
pfam10168 |
Nuclear pore component; Nup88 can be divided into two structural domains; the N-terminal ... |
673-816 |
1.81e-03 |
|
Nuclear pore component; Nup88 can be divided into two structural domains; the N-terminal two-thirds of the protein has no obvious structural motifs but is the region for binding to Nup98, one of the components of the nuclear pore. the C-terminal end is a predicted coiled-coil domain. Nup88 is overexpressed in tumour cells.
Pssm-ID: 462975 [Multi-domain] Cd Length: 713 Bit Score: 42.34 E-value: 1.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 673 VQAWKAQLDQAMQELRLMEDEWKKVQEAyqhwqneniriqAEQKgaSNQFESAKlKKEETFARFMKELEQSgftdqFTYK 752
Cdd:pfam10168 563 VKLLKLQKEQQLQELQSLEEERKSLSER------------AEKL--AEKYEEIK-DKQEKLMRRCKKVLQR-----LNSQ 622
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 753 EAKLSDAQMEMlQKEIQGYYSSLEVLAKQIEELNS---------------------ELKDKEYMDITS----LGEHIKEL 807
Cdd:pfam10168 623 LPVLSDAEREM-KKELETINEQLKHLANAIKQAKKkmnyqryqiaksqsirkksslSLSEKQRKTIKEilkqLGSEIDEL 701
|
....*....
gi 447170203 808 EINLDIIKE 816
Cdd:pfam10168 702 IKQVKDINK 710
|
|
| YydB |
COG5293 |
Uncharacterized conserved protein YydD, contains DUF2326 domain [Function unknown]; |
25-497 |
1.83e-03 |
|
Uncharacterized conserved protein YydD, contains DUF2326 domain [Function unknown];
Pssm-ID: 444096 [Multi-domain] Cd Length: 572 Bit Score: 42.24 E-value: 1.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 25 LGEHRIFAISGNT--GAGKTTIFDAICYVLYGEASgeeRSDTSMLRSQFADDnvytSVELTFQLKGKRYEIKRQLGHKKQ 102
Cdd:COG5293 26 LGEISSPENDKDStnGVGKSTLLELIDFCLGADKD---KKRFLKHEDELGDH----TFFLEFELDGKDLTIRRSVSDPKK 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 103 GNKTITGHAvelyevIDGENVPavdrfhvtdvNKKMEDLigLSKHQFSqIVMLPQGEFRKLLTSETENKEEILRRIFKT- 181
Cdd:COG5293 99 ISLCGDGYE------WDHEKVS----------LEEAKAL--LEELLFG-LPALKGPSFRSLLGYFLRRQGDDFKDPLQLf 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 182 -------DRYKLMRELLD------QKRKQWKDVLQEKQKERELYFRNVFKLPIRDGALLETLVAqehvnthqvveVLEQE 248
Cdd:COG5293 160 staqkdaDWKLYLAYLLGldwdlaAEKYELKEEIKELKKLRKALKDELIGSVVKSISELRAEIL-----------ELEEE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 249 TTVYKAEVEQLQV-EQDVQ-TKQLKDAETRfhaaksvnekfidLQQKNEKYNTLQENRAAIEG--KEKSFKRAEQAKRLl 324
Cdd:COG5293 229 IEKLEKDLEKFDVaENYEElEKELDELKRE-------------INELRNERYSLERRLKKIERslEEEIDIDPDELEKL- 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 325 pfeqwYEEAMqneqkaesllkqiIVKQEQIMNSFElaqekyEVVK-NKELEREEAKKLVQRLEELQAIIESLaERKLNLQ 403
Cdd:COG5293 295 -----YEEAG-------------VFFPDQVKKRFE------EVEAfHKSIVENRREYLEEEIAELEAELEEL-EAELAEL 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 404 NAEI-QIGKLKESMQKLDqQLEEHTSQKQGMSDELQQLEQALEQYVAKVEELTNMREDAKVLKQAYDVWQEKQKfEQEKE 482
Cdd:COG5293 350 GKERaELLSLLDSKGALD-KYKELQEELAELEAELEELESRLEKLQELEDEIRELKEERAELKEEIESDIEERK-ELLDE 427
|
490
....*....|....*.
gi 447170203 483 aANNKMQVAV-RAYEN 497
Cdd:COG5293 428 -INKLFSEIVeELYGN 442
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
280-481 |
1.88e-03 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 42.06 E-value: 1.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 280 AKSVNEKFIDLQQKNEKYNTLQENRAAIEGKEKSFKRAEQAKRLLPFEQWYEEAMQNEQKAESLLKQIivKQEQIMNSFE 359
Cdd:COG4717 296 EKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEEL--QLEELEQEIA 373
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 360 LAQEKYEVVKNKELER-----EEAKKLVQRLEELQAIIESLAE------RKLNLQNAEIQIGKLKESMQKLDQQLEEHTS 428
Cdd:COG4717 374 ALLAEAGVEDEEELRAaleqaEEYQELKEELEELEEQLEELLGeleellEALDEEELEEELEELEEELEELEEELEELRE 453
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 429 QKQGMSDELQQLE------QALEQYVAKVEELTNMREDAKVLKQAYDVWQE-KQKFEQEK 481
Cdd:COG4717 454 ELAELEAELEQLEedgelaELLQELEELKAELRELAEEWAALKLALELLEEaREEYREER 513
|
|
| ABC_SMC1_euk |
cd03275 |
ATP-binding cassette domain of eukaryotic SMC1 proteins; The structural maintenance of ... |
4-123 |
2.37e-03 |
|
ATP-binding cassette domain of eukaryotic SMC1 proteins; The structural maintenance of chromosomes (SMC) proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-terminal domain contains a 'Walker A' nucleotide-binding domain (GxxGxGKS/T, in the single-letter amino-acid code), which by mutational studies has been shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resembles a 'Walker B' motif, and a motif with homology to the signature sequence of the ATP-binding cassette (ABC) family of ATPases. The sequence homology within the carboxy-terminal domain is relatively high within the SMC1-SMC4 group, whereas SMC5 and SMC6 show some divergence in both of these sequences. In eukaryotic cells, the proteins are found as heterodimers of SMC1 paired with SMC3, SMC2 with SMC4, and SMC5 with SMC6 (formerly known as Rad18).
Pssm-ID: 213242 [Multi-domain] Cd Length: 247 Bit Score: 41.02 E-value: 2.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 4 IQLIMTAFGPYKQKEVIDFEDlgehRIFAISGNTGAGKTTIFDAICYVLyGEASgeersdtSMLRSQFADDNVY------ 77
Cdd:cd03275 2 KRLELENFKSYKGRHVIGPFD----RFTCIIGPNGSGKSNLMDAISFVL-GEKS-------SHLRSKNLKDLIYrarvgk 69
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 447170203 78 -----TSVELTFQLKGKRYEIKRqlghkkqgnKTITGHAVELYevIDGENV 123
Cdd:cd03275 70 pdsnsAYVTAVYEDDDGEEKTFR---------RIITGGSSSYR--INGKVV 109
|
|
| COG5022 |
COG5022 |
Myosin heavy chain [General function prediction only]; |
281-485 |
2.38e-03 |
|
Myosin heavy chain [General function prediction only];
Pssm-ID: 227355 [Multi-domain] Cd Length: 1463 Bit Score: 41.99 E-value: 2.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 281 KSVNEKFIDLQQKNEKYNTLQEN-------RAA--IEGKEKSFKRAEQAKRLLPfEQWYEEAMQNEQKAEsllKQIIVKQ 351
Cdd:COG5022 813 RSYLACIIKLQKTIKREKKLRETeevefslKAEvlIQKFGRSLKAKKRFSLLKK-ETIYLQSAQRVELAE---RQLQELK 888
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 352 EQIMNSFELAQekyevvKNKELERE--EAKKLVQ--RLEELQAIIESLAERKLNLQNAEI------------QIGKLKES 415
Cdd:COG5022 889 IDVKSISSLKL------VNLELESEiiELKKSLSsdLIENLEFKTELIARLKKLLNNIDLeegpsieyvklpELNKLHEV 962
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 416 MQKLDQ----------QLEEHTSQKQGMSDELQQLEQALEQYV-------AKVEELTNMREDAKVLKQAYD-VWQEKQKF 477
Cdd:COG5022 963 ESKLKEtseeyedllkKSTILVREGNKANSELKNFKKELAELSkqygalqESTKQLKELPVEVAELQSASKiISSESTEL 1042
|
....*...
gi 447170203 478 EQEKEAAN 485
Cdd:COG5022 1043 SILKPLQK 1050
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
29-466 |
2.41e-03 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 41.82 E-value: 2.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 29 RIFAISGNTGAGKTTIFDAICYVLY-----------GEASGEERSDTSMLRSQFADDNVYTSVeltfqlkgkRYEIKRql 97
Cdd:COG4913 25 RGTLLTGDNGSGKSTLLDAIQTLLVpakrprfnkaaNDAGKSDRTLLSYVRGKYGSERDEAGT---------RPVYLR-- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 98 ghkkqGNKTITGHAVELYEVIDGENVPAVDRFHVTDVNKKMEDLI--------GLSKHQFSQIVM-LPQGEFRKLLTSE- 167
Cdd:COG4913 94 -----PGDTWSAIAATFANDGSGQTVTLAQVFWLKGDASSLGDVKrffviadgPLDLEDFEEFAHgFDIRALKARLKKQg 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 168 ---TENKEEILRRIfktdrYKLMR-------ELLD--QKRKQWKDVlqekqkeRELYFRNVfkLPIRD-GALLETLVAQ- 233
Cdd:COG4913 169 vefFDSFSAYLARL-----RRRLGigsekalRLLHktQSFKPIGDL-------DDFVREYM--LEEPDtFEAADALVEHf 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 234 -EHVNTHQVVEVLEQEttvykaeVEQLQveqdvqtkQLKDAETRFHAAKsvnekfidlqqknEKYNTLQENRAAIEGKEK 312
Cdd:COG4913 235 dDLERAHEALEDAREQ-------IELLE--------PIRELAERYAAAR-------------ERLAELEYLRAALRLWFA 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 313 SFKRAEQAKRLlpfEQWYEEAMQNEQKAESLLKQIivkqeqimnsfELAQEKYEvvknkELEREEAKKLVQRLEELQAII 392
Cdd:COG4913 287 QRRLELLEAEL---EELRAELARLEAELERLEARL-----------DALREELD-----ELEAQIRGNGGDRLEQLEREI 347
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447170203 393 E----SLAERKLNLQNAEIQIGKLKESMQKLDQQLEEHTSQKQGMSDELQQLEQALEQYVAKVE-ELTNMREDAKVLKQ 466
Cdd:COG4913 348 ErlerELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEaALRDLRRELRELEA 426
|
|
| Spc7 |
smart00787 |
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ... |
311-456 |
2.73e-03 |
|
Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.
Pssm-ID: 197874 [Multi-domain] Cd Length: 312 Bit Score: 41.16 E-value: 2.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 311 EKSFKRAEQAKRLLPFEQWYEEAMQneqkaesLLKQIIVKQEQIMNsfELAQEKYEVVKNKELEREEAKKLVQRLEELQA 390
Cdd:smart00787 116 DKQFQLVKTFARLEAKKMWYEWRMK-------LLEGLKEGLDENLE--GLKEDYKLLMKELELLNSIKPKLRDRKDALEE 186
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 447170203 391 IIESLAERKLNLQNA-EIQIGKLKESMQKLDQQLEEHTSQKQGMSDELQQLEQALEQYVAKVEELTN 456
Cdd:smart00787 187 ELRQLKQLEDELEDCdPTELDRAKEKLKKLLQEIMIKVKKLEELEEELQELESKIEDLTNKKSELNT 253
|
|
| PRK00409 |
PRK00409 |
recombination and DNA strand exchange inhibitor protein; Reviewed |
376-483 |
3.13e-03 |
|
recombination and DNA strand exchange inhibitor protein; Reviewed
Pssm-ID: 234750 [Multi-domain] Cd Length: 782 Bit Score: 41.35 E-value: 3.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 376 EEAKKLV-QRLEELQAIIESLAERKLNLQNAEIQIGKLKESMQKLDQQLEEhtsQKQGMSDELQQLEQALEQ-YVAKVEE 453
Cdd:PRK00409 505 EEAKKLIgEDKEKLNELIASLEELERELEQKAEEAEALLKEAEKLKEELEE---KKEKLQEEEDKLLEEAEKeAQQAIKE 581
|
90 100 110
....*....|....*....|....*....|
gi 447170203 454 LtnMREDAKVLKQAYDVWQEKQKFEQEKEA 483
Cdd:PRK00409 582 A--KKEADEIIKELRQLQKGGYASVKAHEL 609
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
225-469 |
4.08e-03 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 41.16 E-value: 4.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 225 ALLETLVAQEHVNTHQVVEVLEQETTVYKAEvEQLQVEQDVQTKQLK---DAETRFHAAKSVN---EKFIDLQQKNEKYN 298
Cdd:COG3206 94 PVLERVVDKLNLDEDPLGEEASREAAIERLR-KNLTVEPVKGSNVIEisyTSPDPELAAAVANalaEAYLEQNLELRREE 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 299 T----------LQENRAAIEGKEKSFKRAEQAKRLLPFEqwyEEAMQNEQKAESLLKQIIVKQEQI------MNSFELAQ 362
Cdd:COG3206 173 ArkalefleeqLPELRKELEEAEAALEEFRQKNGLVDLS---EEAKLLLQQLSELESQLAEARAELaeaearLAALRAQL 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 363 EKYEVVKNKELEREEAKKLVQRLEELQAIIESLAERKLN----LQNAEIQIGKLKESMQK--------LDQQLEEHTSQK 430
Cdd:COG3206 250 GSGPDALPELLQSPVIQQLRAQLAELEAELAELSARYTPnhpdVIALRAQIAALRAQLQQeaqrilasLEAELEALQARE 329
|
250 260 270
....*....|....*....|....*....|....*....
gi 447170203 431 QGMSDELQQLEQALEQYVAKVEELTNMREDAKVLKQAYD 469
Cdd:COG3206 330 ASLQAQLAQLEARLAELPELEAELRRLEREVEVARELYE 368
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
375-707 |
4.14e-03 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 41.09 E-value: 4.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 375 REEAKKLVQRL----EELQAIIESLAERKLNLQNAEIQIGKLKESMQKLDQQLeehtsqkQGMSDELQQLEQAL------ 444
Cdd:COG3096 277 ANERRELSERAlelrRELFGARRQLAEEQYRLVEMARELEELSARESDLEQDY-------QAASDHLNLVQTALrqqeki 349
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 445 EQYVAKVEELT-NMREDAKVLKQAYDVWQ--EKQKFEQEKEAANNKMQVA--VRAYENMERRWLSEQAGILALhlhdGES 519
Cdd:COG3096 350 ERYQEDLEELTeRLEEQEEVVEEAAEQLAeaEARLEAAEEEVDSLKSQLAdyQQALDVQQTRAIQYQQAVQAL----EKA 425
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 520 CPVCGSTN-HPQKATEQSNAIDEKE------LNDLRDKKNIAEKLNVQVEEKWNFY--------RLQYEQVIEEVVKRGY 584
Cdd:COG3096 426 RALCGLPDlTPENAEDYLAAFRAKEqqateeVLELEQKLSVADAARRQFEKAYELVckiageveRSQAWQTARELLRRYR 505
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 585 NSEKLAETYSALVQKGKQLAADVNTLKASEETRKQIAVNMKSVEEKIEELQKQKREVETMQHRTEMEcmqlrtsyehdKR 664
Cdd:COG3096 506 SQQALAQRLQQLRAQLAELEQRLRQQQNAERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQ-----------AA 574
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 447170203 665 NIPENLQTVQAWKAQLDQAMQELRLMEDEWKKVQEAYQHWQNE 707
Cdd:COG3096 575 EAVEQRSELRQQLEQLRARIKELAARAPAWLAAQDALERLREQ 617
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
337-643 |
4.86e-03 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 41.20 E-value: 4.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 337 EQKAESLLKQIIVKQEQIMnsfELAQEKYEVVKNKELEREEAKKLVQRLEELQAIIESLAERklnLQNAEIQIGKLKESM 416
Cdd:TIGR02168 690 EEKIAELEKALAELRKELE---ELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEER---IAQLSKELTELEAEI 763
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 417 QKLDQQLEEHTSQKQGMSDELQQLEQALEQY-----------VAKVEELTNMREDA--------KVLKQAYDVWQEKQKF 477
Cdd:TIGR02168 764 EELEERLEEAEEELAEAEAEIEELEAQIEQLkeelkalrealDELRAELTLLNEEAanlrerleSLERRIAATERRLEDL 843
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 478 EQEKEAANNKMQVAVRAYENMERRWLSEQAGI-LALHLHDGESCPVCGSTNHPQKATEQSNAIdEKELNDLRDKKNIAEK 556
Cdd:TIGR02168 844 EEQIEELSEDIESLAAEIEELEELIEELESELeALLNERASLEEALALLRSELEELSEELREL-ESKRSELRRELEELRE 922
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 557 LNVQVEEKWNFYRLQYEQVIEEVVKRGY-NSEKLAETYSALVQKGKQLAADVNTLKASeetRKQI-AVNMKSVEEkIEEL 634
Cdd:TIGR02168 923 KLAQLELRLEGLEVRIDNLQERLSEEYSlTLEEAEALENKIEDDEEEARRRLKRLENK---IKELgPVNLAAIEE-YEEL 998
|
....*....
gi 447170203 635 QKQKREVET 643
Cdd:TIGR02168 999 KERYDFLTA 1007
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
560-852 |
4.89e-03 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 40.82 E-value: 4.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 560 QVEEKWNFYRLQYEQVIEEVVKRGYNSEKlAETYSALvQKGKQLAADVNTLKASEETRKQIAVNMKSVEEKIEELQKQKR 639
Cdd:TIGR02169 181 EVEENIERLDLIIDEKRQQLERLRREREK-AERYQAL-LKEKREYEGYELLKEKEALERQKEAIERQLASLEEELEKLTE 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 640 EVETMQHRTEMECMQLRTSYEHDKRNIPENLQTVQA----WKAQLDQAMQELRLMEDEWKKVQEAYQHWQNENIRIQAEQ 715
Cdd:TIGR02169 259 EISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEkigeLEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEI 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 716 KGASNQFESAKLKKEETFARFMK----------ELEQSGFTDQFTYKEAKLSDAQMEMLQKEIQGYYSSLEVLAKQIEEL 785
Cdd:TIGR02169 339 EELEREIEEERKRRDKLTEEYAElkeeledlraELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRL 418
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 447170203 786 NSELKDKEyMDITSLGEHIKELEINLDI----IKEKRQRAQNAVTYISDLHENIRRIDEQIHDEEKAFQEL 852
Cdd:TIGR02169 419 SEELADLN-AAIAGIEAKINELEEEKEDkaleIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKL 488
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
182-455 |
5.38e-03 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 41.09 E-value: 5.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 182 DRYKLMRELLDQKRKQWKDVLQ-EKQKERELYF-RNVFKLPIRDGALLETL-VAQEHVNthQVVEVLEQETTV--YKAEV 256
Cdd:COG3096 279 ERRELSERALELRRELFGARRQlAEEQYRLVEMaRELEELSARESDLEQDYqAASDHLN--LVQTALRQQEKIerYQEDL 356
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 257 EQLQVEQDVQ-------TKQLKDAETRFHAA----KSVNEKFIDLQQKNEkyntLQENRA-----AIEGKEKSfKRAEQA 320
Cdd:COG3096 357 EELTERLEEQeevveeaAEQLAEAEARLEAAeeevDSLKSQLADYQQALD----VQQTRAiqyqqAVQALEKA-RALCGL 431
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 321 KRLLP--FEQWYEEAMQNEQKAESLLKQiivkQEQIMNSFELA----QEKYEVVKN--KELEREEA-------------- 378
Cdd:COG3096 432 PDLTPenAEDYLAAFRAKEQQATEEVLE----LEQKLSVADAArrqfEKAYELVCKiaGEVERSQAwqtarellrryrsq 507
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 379 KKLVQRLEELQAIIESLAERKLNLQNAEIQIGK--------------LKESMQKLDQQLEEHTSQKQGMSDELQQLEQAL 444
Cdd:COG3096 508 QALAQRLQQLRAQLAELEQRLRQQQNAERLLEEfcqrigqqldaaeeLEELLAELEAQLEELEEQAAEAVEQRSELRQQL 587
|
330
....*....|.
gi 447170203 445 EQYVAKVEELT 455
Cdd:COG3096 588 EQLRARIKELA 598
|
|
| ABC_SMC2_euk |
cd03273 |
ATP-binding cassette domain of eukaryotic SMC2 proteins; The structural maintenance of ... |
1-52 |
5.69e-03 |
|
ATP-binding cassette domain of eukaryotic SMC2 proteins; The structural maintenance of chromosomes (SMC) proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-terminal domain contains a 'Walker A' nucleotide-binding domain (GxxGxGKS/T, in the single-letter amino-acid code), which by mutational studies has been shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resembles a 'Walker B' motif, and a motif with homology to the signature sequence of the ATP-binding cassette (ABC) family of ATPases. The sequence homology within the carboxy-terminal domain is relatively high within the SMC1-SMC4 group, whereas SMC5 and SMC6 show some divergence in both of these sequences. In eukaryotic cells, the proteins are found as heterodimers of SMC1 paired with SMC3, SMC2 with SMC4, and SMC5 with SMC6 (formerly known as Rad18).
Pssm-ID: 213240 [Multi-domain] Cd Length: 251 Bit Score: 39.59 E-value: 5.69e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 447170203 1 MRPIQLIMTAFGPYKQKEVIdfedLGEHRIF-AISGNTGAGKTTIFDAICYVL 52
Cdd:cd03273 1 MHIKEIILDGFKSYATRTVI----SGFDPQFnAITGLNGSGKSNILDAICFVL 49
|
|
| ABC_SMC_barmotin |
cd03278 |
ATP-binding cassette domain of barmotin, a member of the SMC protein family; Barmotin is a ... |
5-96 |
5.89e-03 |
|
ATP-binding cassette domain of barmotin, a member of the SMC protein family; Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-terminal domain contains a 'Walker A' nucleotide-binding domain (GxxGxGKS/T, in the single-letter amino-acid code), which by mutational studies has been shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resembles a 'Walker B' motif, and a motif with homology to the signature sequence of the ATP-binding cassette (ABC) family of ATPases. The sequence homology within the carboxy-terminal domain is relatively high within the SMC1-SMC4 group, whereas SMC5 and SMC6 show some divergence in both of these sequences. In eukaryotic cells, the proteins are found as heterodimers of SMC1 paired with SMC3, SMC2 with SMC4, and SMC5 with SMC6 (formerly known as Rad18).
Pssm-ID: 213245 [Multi-domain] Cd Length: 197 Bit Score: 38.99 E-value: 5.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 5 QLIMTAFGPYKQKEVIDFEDlgehRIFAISGNTGAGKTTIFDAICYVLyGEAS-----GEERSDTSMLRSQFADDNVYTS 79
Cdd:cd03278 3 KLELKGFKSFADKTTIPFPP----GLTAIVGPNGSGKSNIIDAIRWVL-GEQSakslrGEKMSDVIFAGSETRKPANFAE 77
|
90
....*....|....*..
gi 447170203 80 VELTFQLKGKRYEIKRQ 96
Cdd:cd03278 78 VTLTFDNSDGRYSIISQ 94
|
|
| ABC_ATPase |
cd00267 |
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ... |
932-1004 |
6.11e-03 |
|
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.
Pssm-ID: 213179 [Multi-domain] Cd Length: 157 Bit Score: 38.38 E-value: 6.11e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 447170203 932 LSGGEKFNASLCLALGMADVIqayeggisietMFIDEGFGSLDEESLTKAVDALIDLQKSGRFIGVISHVQEL 1004
Cdd:cd00267 81 LSGGQRQRVALARALLLNPDL-----------LLLDEPTSGLDPASRERLLELLRELAEEGRTVIIVTHDPEL 142
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
320-511 |
7.35e-03 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 40.39 E-value: 7.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 320 AKRLLPFEQWYEEAMQNEQKAESLLKQIIVKQEQIMNSFEL------AQEKYEVVK---------NKELEREEAKK---- 380
Cdd:COG3206 100 VDKLNLDEDPLGEEASREAAIERLRKNLTVEPVKGSNVIEIsytspdPELAAAVANalaeayleqNLELRREEARKalef 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 381 LVQRLEELQAIIESlAERKL-------NLQNAEIQIGKLKESMQKLDQQLEEHTSQKQGMSDELQQLEQALEQYVAKVEE 453
Cdd:COG3206 180 LEEQLPELRKELEE-AEAALeefrqknGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLAALRAQLGSGPDALPE 258
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 447170203 454 LTNMREDAKVLKQAYDVWQEKQKFEQEKEAANNKMQVAVRAYENMERRWLSEQAGILA 511
Cdd:COG3206 259 LLQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQEAQRILA 316
|
|
| PRK11147 |
PRK11147 |
ABC transporter ATPase component; Reviewed |
330-461 |
8.72e-03 |
|
ABC transporter ATPase component; Reviewed
Pssm-ID: 236861 [Multi-domain] Cd Length: 635 Bit Score: 39.93 E-value: 8.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447170203 330 YEEAMQneQKAESL-LKQIIVKQEQimnsfELAQEKYEVVKNKelereeAKKL---VQR-LEELQAIIESLaerklnlqn 404
Cdd:PRK11147 523 YHDARQ--QQAQYLaLKQPAVKKKE-----EAAAPKAETVKRS------SKKLsykLQReLEQLPQLLEDL--------- 580
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 447170203 405 aEIQIGKLKESMQKLD--QQLEEHTSQKQgmsDELQQLEQALEQYVAKVEELTNMREDA 461
Cdd:PRK11147 581 -EAEIEALQAQVADADffSQPHEQTQKVL---ADLADAEQELEVAFERWEELEALKNGG 635
|
|
| |
