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Conserved domains on  [gi|447000797|ref|WP_001078053|]
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MULTISPECIES: MarR family winged helix-turn-helix transcriptional regulator [Bacillus]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_ARSR super family cl46857
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 28-102 2.33e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


The actual alignment was detected with superfamily member smart00347:

Pssm-ID: 481197 [Multi-domain]  Cd Length: 101  Bit Score: 37.19  E-value: 2.33e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447000797    28 LMAFINENGEaqmLNKTAVAEMIQLSKPTVFATVNSFYCAGYIDETRV---GRSKIYTLSDLGVEIVECFKQKAMEMR 102
Cdd:smart00347  15 VLRILYEEGP---LSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSpedRRSVLVSLTEEGRELIEQLLEARSETL 89
 
Name Accession Description Interval E-value
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
28-102 2.33e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 37.19  E-value: 2.33e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447000797    28 LMAFINENGEaqmLNKTAVAEMIQLSKPTVFATVNSFYCAGYIDETRV---GRSKIYTLSDLGVEIVECFKQKAMEMR 102
Cdd:smart00347  15 VLRILYEEGP---LSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSpedRRSVLVSLTEEGRELIEQLLEARSETL 89
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
44-85 6.82e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 36.78  E-value: 6.82e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 447000797  44 TAVAEMIQLSKPTVFATVNSFYCAGYIDETRVGRSKIYTLSD 85
Cdd:COG3398  115 KELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNP 156
 
Name Accession Description Interval E-value
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
28-102 2.33e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 37.19  E-value: 2.33e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 447000797    28 LMAFINENGEaqmLNKTAVAEMIQLSKPTVFATVNSFYCAGYIDETRV---GRSKIYTLSDLGVEIVECFKQKAMEMR 102
Cdd:smart00347  15 VLRILYEEGP---LSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSpedRRSVLVSLTEEGRELIEQLLEARSETL 89
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
44-85 6.82e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 36.78  E-value: 6.82e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 447000797  44 TAVAEMIQLSKPTVFATVNSFYCAGYIDETRVGRSKIYTLSD 85
Cdd:COG3398  115 KELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNP 156
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
25-103 1.09e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 36.10  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447000797  25 YQVLMAfINENGEAQMlnkTAVAEMIQLSKPTVFATVNSFYCAGYIDETRV---GRSKIYTLSDLGVEIVECFKQKAMEM 101
Cdd:COG1846   41 FRVLAA-LAEAGGLTQ---SELAERLGLTKSTVSRLLDRLEEKGLVEREPDpedRRAVLVRLTEKGRALLEEARPALEAL 116


                 ..
gi 447000797 102 RN 103
Cdd:COG1846  117 LA 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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