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Conserved domains on  [gi|446930050|ref|WP_001007306|]
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MULTISPECIES: type I restriction enzyme HsdR N-terminal domain-containing protein [Leptospira]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG2810 super family cl43716
Predicted type IV restriction endonuclease [Defense mechanisms];
9-138 6.26e-23

Predicted type IV restriction endonuclease [Defense mechanisms];


The actual alignment was detected with superfamily member COG2810:

Pssm-ID: 442059 [Multi-domain]  Cd Length: 340  Bit Score: 96.20  E-value: 6.26e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446930050   9 ERISSGVKKFQPILTSAKTRDVNESDTVVIITDLLSEVFGYD--KYSEITTEHVIKKTFCDLAIKIDGKVKLLIEIKAIG 86
Cdd:COG2810    5 ADLQSLVERILRNLDYLSLRSANEAATRQEFIDPLLEALGWDidNPEEVIPEERVEGGRPDYALRLNGKRKLFVEAKKPG 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446930050  87 LELKDDYIRQAIDYGANSGIEWVILTNGMNWQIYRITF---SKPIDKEMVYEINF 138
Cdd:COG2810   85 VNLKDKPARQARSYAWSSGVRWAILTNGREWRVYDAQEktsPRPIELDTALEARL 139
 
Name Accession Description Interval E-value
COG2810 COG2810
Predicted type IV restriction endonuclease [Defense mechanisms];
9-138 6.26e-23

Predicted type IV restriction endonuclease [Defense mechanisms];


Pssm-ID: 442059 [Multi-domain]  Cd Length: 340  Bit Score: 96.20  E-value: 6.26e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446930050   9 ERISSGVKKFQPILTSAKTRDVNESDTVVIITDLLSEVFGYD--KYSEITTEHVIKKTFCDLAIKIDGKVKLLIEIKAIG 86
Cdd:COG2810    5 ADLQSLVERILRNLDYLSLRSANEAATRQEFIDPLLEALGWDidNPEEVIPEERVEGGRPDYALRLNGKRKLFVEAKKPG 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446930050  87 LELKDDYIRQAIDYGANSGIEWVILTNGMNWQIYRITF---SKPIDKEMVYEINF 138
Cdd:COG2810   85 VNLKDKPARQARSYAWSSGVRWAILTNGREWRVYDAQEktsPRPIELDTALEARL 139
HSDR_N_2 pfam13588
Type I restriction enzyme R protein N terminus (HSDR_N); This family consists of a number of N ...
 43-132 9.98e-08

Type I restriction enzyme R protein N terminus (HSDR_N); This family consists of a number of N terminal regions found in type I restriction enzyme R (HSDR) proteins. Restriction and modification (R/M) systems are found in a wide variety of prokaryotes and are thought to protect the host bacterium from the uptake of foreign DNA. Type I restriction and modification systems are encoded by three genes: hsdR, hsdM, and hsdS. The three polypeptides, HsdR, HsdM, and HsdS, often assemble to give an enzyme (R2M2S1) that modifies hemimethylated DNA and restricts unmethylated DNA.


Pssm-ID: 433331 [Multi-domain]  Cd Length: 110  Bit Score: 49.13  E-value: 9.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446930050   43 LSEVFGYDKYS---EITTEHVIKKTFCDLAIKI-DGKVKLLIEIKAIGLELKDDYIRQAIDYGANSGIEWVILTNGMNWQ 118
Cdd:pfam13588  13 LINELGYPKELiavEKPLQLGSKKKRADIVVYNkDGKPYILVECKAPSIKISQKVFDQLARYNSVLGAPFLVVTNGLQHI 92

                          90
                  ....*....|....
gi 446930050  119 IYRITFSKPIDKEM 132
Cdd:pfam13588  93 CFKVDYDKQQFEFL 106
 
Name Accession Description Interval E-value
COG2810 COG2810
Predicted type IV restriction endonuclease [Defense mechanisms];
9-138 6.26e-23

Predicted type IV restriction endonuclease [Defense mechanisms];


Pssm-ID: 442059 [Multi-domain]  Cd Length: 340  Bit Score: 96.20  E-value: 6.26e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446930050   9 ERISSGVKKFQPILTSAKTRDVNESDTVVIITDLLSEVFGYD--KYSEITTEHVIKKTFCDLAIKIDGKVKLLIEIKAIG 86
Cdd:COG2810    5 ADLQSLVERILRNLDYLSLRSANEAATRQEFIDPLLEALGWDidNPEEVIPEERVEGGRPDYALRLNGKRKLFVEAKKPG 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446930050  87 LELKDDYIRQAIDYGANSGIEWVILTNGMNWQIYRITF---SKPIDKEMVYEINF 138
Cdd:COG2810   85 VNLKDKPARQARSYAWSSGVRWAILTNGREWRVYDAQEktsPRPIELDTALEARL 139
HSDR_N_2 pfam13588
Type I restriction enzyme R protein N terminus (HSDR_N); This family consists of a number of N ...
 43-132 9.98e-08

Type I restriction enzyme R protein N terminus (HSDR_N); This family consists of a number of N terminal regions found in type I restriction enzyme R (HSDR) proteins. Restriction and modification (R/M) systems are found in a wide variety of prokaryotes and are thought to protect the host bacterium from the uptake of foreign DNA. Type I restriction and modification systems are encoded by three genes: hsdR, hsdM, and hsdS. The three polypeptides, HsdR, HsdM, and HsdS, often assemble to give an enzyme (R2M2S1) that modifies hemimethylated DNA and restricts unmethylated DNA.


Pssm-ID: 433331 [Multi-domain]  Cd Length: 110  Bit Score: 49.13  E-value: 9.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446930050   43 LSEVFGYDKYS---EITTEHVIKKTFCDLAIKI-DGKVKLLIEIKAIGLELKDDYIRQAIDYGANSGIEWVILTNGMNWQ 118
Cdd:pfam13588  13 LINELGYPKELiavEKPLQLGSKKKRADIVVYNkDGKPYILVECKAPSIKISQKVFDQLARYNSVLGAPFLVVTNGLQHI 92

                          90
                  ....*....|....
gi 446930050  119 IYRITFSKPIDKEM 132
Cdd:pfam13588  93 CFKVDYDKQQFEFL 106
COG4748 COG4748
Uncharacterized conserved protein, contains restriction enzyme R protein N terminal (HSDR_N) ...
 45-159 3.91e-06

Uncharacterized conserved protein, contains restriction enzyme R protein N terminal (HSDR_N) domain [Function unknown];


Pssm-ID: 443782  Cd Length: 355  Bit Score: 47.57  E-value: 3.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446930050  45 EVFGYDKY--SEITTEHV----IKKTF-CDLAIKIDGKVKLLIEIKAIGLELKDDYIRQAIDYGANSGIEWVILTNGMNW 117
Cdd:COG4748   37 QILGYDVFnpTEVVPEYTadvgTKKGEkVDYAILKDGQPVILIECKGVGEDLDINHASQLFRYFHVTEARFGILTNGIEY 116

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 446930050 118 QIY-RITFSKPIDKEMVYEINFSNINpkiENHIEPIYYLCKEA 159
Cdd:COG4748  117 RFYtDLDEPNKMDEKPFFEFDLLDLK---ESDIPELKKFTKSA 156
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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