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Conserved domains on  [gi|446922572|ref|WP_000999828|]
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MULTISPECIES: HK97 family phage prohead protease [Enterobacteriaceae]

Protein Classification

HK97 family phage prohead protease( domain architecture ID 10519032)

HK97 family phage prohead protease similar to Escherichia virus HK97 prohead protease that is involved in virion assembly and maturation

EC:  3.4.21.-
Gene Ontology:  GO:0008236|GO:0046797|GO:0006508
MEROPS:  S78
PubMed:  7723019|22297521

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Peptidase_S78 pfam04586
Caudovirus prohead serine protease; Family of Caudovirus prohead serine proteases also found ...
12-171 6.08e-54

Caudovirus prohead serine protease; Family of Caudovirus prohead serine proteases also found in a number of bacteria possibly as the result of horizontal transfer.


:

Pssm-ID: 309640  Cd Length: 160  Bit Score: 169.46  E-value: 6.08e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446922572   12 EVRAEqyDNAPTHILGYGSVFNSRSEPLWGFREIIKPGAFDDVL-NDDVRGLFNHDPNFILGRSSAGTLSLSVDERGLRY 90
Cdd:pfam04586   2 EVRSV--EEGGITISGYASVFNTVSELLGGFREVIAPGAFDNTLkSADVPALFNHDTNKVLGRTKSGTLELSEDEVGLRF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446922572   91 DIVAPDTPTICDLvLSPMLRGDINQSSFAFRVArdGESWYEDDEGIVIREITRIsRLYDVSPVTYPAYQDA--DSGVRSM 168
Cdd:pfam04586  80 ELDLPDTTVARDL-YELMKRGDIDGCSFGFRVV--GDSWDEREDKVPVRTITEV-ELIEVSIVTFPAYPDTsvEVSARSL 155

                  ...
gi 446922572  169 KAW 171
Cdd:pfam04586 156 ENT 158
 
Name Accession Description Interval E-value
Peptidase_S78 pfam04586
Caudovirus prohead serine protease; Family of Caudovirus prohead serine proteases also found ...
12-171 6.08e-54

Caudovirus prohead serine protease; Family of Caudovirus prohead serine proteases also found in a number of bacteria possibly as the result of horizontal transfer.


Pssm-ID: 309640  Cd Length: 160  Bit Score: 169.46  E-value: 6.08e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446922572   12 EVRAEqyDNAPTHILGYGSVFNSRSEPLWGFREIIKPGAFDDVL-NDDVRGLFNHDPNFILGRSSAGTLSLSVDERGLRY 90
Cdd:pfam04586   2 EVRSV--EEGGITISGYASVFNTVSELLGGFREVIAPGAFDNTLkSADVPALFNHDTNKVLGRTKSGTLELSEDEVGLRF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446922572   91 DIVAPDTPTICDLvLSPMLRGDINQSSFAFRVArdGESWYEDDEGIVIREITRIsRLYDVSPVTYPAYQDA--DSGVRSM 168
Cdd:pfam04586  80 ELDLPDTTVARDL-YELMKRGDIDGCSFGFRVV--GDSWDEREDKVPVRTITEV-ELIEVSIVTFPAYPDTsvEVSARSL 155

                  ...
gi 446922572  169 KAW 171
Cdd:pfam04586 156 ENT 158
COG3740 COG3740
Phage head maturation protease [Mobilome: prophages, transposons];
1-189 3.34e-48

Phage head maturation protease [Mobilome: prophages, transposons];


Pssm-ID: 442954  Cd Length: 183  Bit Score: 155.53  E-value: 3.34e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446922572   1 MNDRETRCySGEVRAEQYDNAPThILGYGSVFNSRSEpLWGFREIIKPGAFDDVL---NDDVRGLFNHDPNFILGRssag 77
Cdd:COG3740    1 MEKPRKFA-ALEIRAVTDDDDGT-IEGYASVFGSPSE-LDRFGEVIAPGAFAKSLaerGSDVPMLWQHDPAKPLGR---- 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446922572  78 TLSLSVDERGLRYDI-VAPDTPTICDlVLSPMLRGDINQSSFAFRVARDgeSWyEDDEGIVIREITRIsRLYDVSPVTYP 156
Cdd:COG3740   74 WDELREDDKGLRVEGrLLPDTPRARD-VYALIKAGAIDGLSIGFRVVKD--EW-ERDGGTGVRTILEV-DLWEVSVVTFP 148
                        170       180       190
                 ....*....|....*....|....*....|...
gi 446922572 157 AYQDADSGVRSMKAWQEARASGALKKAVNERMA 189
Cdd:COG3740  149 AYPDARVSARKSALEAAEAEALRLARALRRARA 181
proheadase_HK97 TIGR01543
phage prohead protease, HK97 family; This model describes the prohead protease of HK97 and ...
25-170 1.77e-33

phage prohead protease, HK97 family; This model describes the prohead protease of HK97 and related phage. It is generally encoded next to the gene for the capsid protein that it processes, and in some cases may be fused to it. This family does not show similarity to the prohead protease of phage T4 (see pfam03420). [Mobile and extrachromosomal element functions, Prophage functions, Protein fate, Other]


Pssm-ID: 273682  Cd Length: 145  Bit Score: 116.83  E-value: 1.77e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446922572   25 ILGYGSVFNSRSEPLWGFrEIIKPGAFDDVL---NDDVRGLFNHDPNFILGRSSAGTlSLSVDERGLRYDI-VAPDTPTI 100
Cdd:TIGR01543   3 FEGYGSVFGNKDSDGWGY-EVFLPGAFTNTLaewNDKVRLLYNHDTALPVGRTVSGT-KLEEDDHGLYGRGkLPPDTPDA 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446922572  101 CDlVLSPMLRGDINQSSFAFRVARDGESWYEDDEGIVIREItrisRLYDVSPVTYPAYQDAdsGVRSMKA 170
Cdd:TIGR01543  81 AD-VYALVKAGDVSGMSFGFRVIKDVWDDREEGDVISLLEA----ALYEVSVTTFPAYPEA--GIAAVKA 143
 
Name Accession Description Interval E-value
Peptidase_S78 pfam04586
Caudovirus prohead serine protease; Family of Caudovirus prohead serine proteases also found ...
12-171 6.08e-54

Caudovirus prohead serine protease; Family of Caudovirus prohead serine proteases also found in a number of bacteria possibly as the result of horizontal transfer.


Pssm-ID: 309640  Cd Length: 160  Bit Score: 169.46  E-value: 6.08e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446922572   12 EVRAEqyDNAPTHILGYGSVFNSRSEPLWGFREIIKPGAFDDVL-NDDVRGLFNHDPNFILGRSSAGTLSLSVDERGLRY 90
Cdd:pfam04586   2 EVRSV--EEGGITISGYASVFNTVSELLGGFREVIAPGAFDNTLkSADVPALFNHDTNKVLGRTKSGTLELSEDEVGLRF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446922572   91 DIVAPDTPTICDLvLSPMLRGDINQSSFAFRVArdGESWYEDDEGIVIREITRIsRLYDVSPVTYPAYQDA--DSGVRSM 168
Cdd:pfam04586  80 ELDLPDTTVARDL-YELMKRGDIDGCSFGFRVV--GDSWDEREDKVPVRTITEV-ELIEVSIVTFPAYPDTsvEVSARSL 155

                  ...
gi 446922572  169 KAW 171
Cdd:pfam04586 156 ENT 158
COG3740 COG3740
Phage head maturation protease [Mobilome: prophages, transposons];
1-189 3.34e-48

Phage head maturation protease [Mobilome: prophages, transposons];


Pssm-ID: 442954  Cd Length: 183  Bit Score: 155.53  E-value: 3.34e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446922572   1 MNDRETRCySGEVRAEQYDNAPThILGYGSVFNSRSEpLWGFREIIKPGAFDDVL---NDDVRGLFNHDPNFILGRssag 77
Cdd:COG3740    1 MEKPRKFA-ALEIRAVTDDDDGT-IEGYASVFGSPSE-LDRFGEVIAPGAFAKSLaerGSDVPMLWQHDPAKPLGR---- 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446922572  78 TLSLSVDERGLRYDI-VAPDTPTICDlVLSPMLRGDINQSSFAFRVARDgeSWyEDDEGIVIREITRIsRLYDVSPVTYP 156
Cdd:COG3740   74 WDELREDDKGLRVEGrLLPDTPRARD-VYALIKAGAIDGLSIGFRVVKD--EW-ERDGGTGVRTILEV-DLWEVSVVTFP 148
                        170       180       190
                 ....*....|....*....|....*....|...
gi 446922572 157 AYQDADSGVRSMKAWQEARASGALKKAVNERMA 189
Cdd:COG3740  149 AYPDARVSARKSALEAAEAEALRLARALRRARA 181
proheadase_HK97 TIGR01543
phage prohead protease, HK97 family; This model describes the prohead protease of HK97 and ...
25-170 1.77e-33

phage prohead protease, HK97 family; This model describes the prohead protease of HK97 and related phage. It is generally encoded next to the gene for the capsid protein that it processes, and in some cases may be fused to it. This family does not show similarity to the prohead protease of phage T4 (see pfam03420). [Mobile and extrachromosomal element functions, Prophage functions, Protein fate, Other]


Pssm-ID: 273682  Cd Length: 145  Bit Score: 116.83  E-value: 1.77e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446922572   25 ILGYGSVFNSRSEPLWGFrEIIKPGAFDDVL---NDDVRGLFNHDPNFILGRSSAGTlSLSVDERGLRYDI-VAPDTPTI 100
Cdd:TIGR01543   3 FEGYGSVFGNKDSDGWGY-EVFLPGAFTNTLaewNDKVRLLYNHDTALPVGRTVSGT-KLEEDDHGLYGRGkLPPDTPDA 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446922572  101 CDlVLSPMLRGDINQSSFAFRVARDGESWYEDDEGIVIREItrisRLYDVSPVTYPAYQDAdsGVRSMKA 170
Cdd:TIGR01543  81 AD-VYALVKAGDVSGMSFGFRVIKDVWDDREEGDVISLLEA----ALYEVSVTTFPAYPEA--GIAAVKA 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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