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Conserved domains on  [gi|446913653|ref|WP_000990909|]
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MULTISPECIES: transcriptional regulator NanR [Escherichia]

Protein Classification

transcriptional regulator NanR( domain architecture ID 11480059)

transcriptional regulator NanR is an HTH-type transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 16-257 4.52e-146

transcriptional regulator NanR; Provisional


:

Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 408.26  E-value: 4.52e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653  16 GRNLRRRPLARKKLSEMVEEELEQMIRRREFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINNGERARVSRP 95
Cdd:PRK03837   1 GRNLRSRPIARKKLSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653  96 SADTIIGELSGMAKDFLS-HPGGIAHFEQLRLFFESSLVRYAAEHATDEQIDLLAKALEINSQSLDNNAAFIRSDVDFHR 174
Cdd:PRK03837  81 SADTIIGQLSGMAKDFLSqSPDGLAHLKQARLFFESSLARYAAEHATDEQIALLRKALERNSQSLGDNAAFIRSDMEFHR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653 175 VLAEIPGNPIFMAIHVALLDWLIAARPTVADqaLHEHNNVSYQQHIAIVDAIRRHDPDEADRALQSHLNSVSATWHAFGQ 254
Cdd:PRK03837 161 VIAEIPGNPIFMAIHEALLDWLIEARPEVVI--LHGHENVTLQEHIAIVDAIRAHDPDEADRALQSHLNRVSALYHALGQ 238


                 ...
gi 446913653 255 TAN 257
Cdd:PRK03837 239 TTN 241
 
Name Accession Description Interval E-value
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 16-257 4.52e-146

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 408.26  E-value: 4.52e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653  16 GRNLRRRPLARKKLSEMVEEELEQMIRRREFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINNGERARVSRP 95
Cdd:PRK03837   1 GRNLRSRPIARKKLSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653  96 SADTIIGELSGMAKDFLS-HPGGIAHFEQLRLFFESSLVRYAAEHATDEQIDLLAKALEINSQSLDNNAAFIRSDVDFHR 174
Cdd:PRK03837  81 SADTIIGQLSGMAKDFLSqSPDGLAHLKQARLFFESSLARYAAEHATDEQIALLRKALERNSQSLGDNAAFIRSDMEFHR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653 175 VLAEIPGNPIFMAIHVALLDWLIAARPTVADqaLHEHNNVSYQQHIAIVDAIRRHDPDEADRALQSHLNSVSATWHAFGQ 254
Cdd:PRK03837 161 VIAEIPGNPIFMAIHEALLDWLIEARPEVVI--LHGHENVTLQEHIAIVDAIRAHDPDEADRALQSHLNRVSALYHALGQ 238


                 ...
gi 446913653 255 TAN 257
Cdd:PRK03837 239 TTN 241
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
22-251 2.95e-55

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 177.43  E-value: 2.95e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653  22 RPLARKKLSEMVEEELEQMIRRREFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINNGERARVSRPSADTII 101
Cdd:COG2186    1 KPIRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653 102 GELSGMakdFLSHPGGIAHFEQLRLFFESSLVRYAAEHATDEQIDLLAKALEINSQSLDNNAAFIRSDVDFHRVLAEIPG 181
Cdd:COG2186   81 DPLALL---LALDDASLRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAADDGEAFAEADLAFHRAIAEASG 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653 182 NPIFMAIHVALLDWLIAARPTVADQalHEHNNVSYQQHIAIVDAIRRHDPDEADRALQSHLNSVSATWHA 251
Cdd:COG2186  158 NPLLALLLESLRELLRRSVRLTLRS--PEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLRE 225
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 29-92 2.17e-19

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 79.20  E-value: 2.17e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446913653   29 LSEMVEEELEQMIRRREFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINNGERARV 92
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
33-92 4.19e-18

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 75.69  E-value: 4.19e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653    33 VEEELEQMIRRREFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINNGERARV 92
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 28-93 2.46e-16

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 71.32  E-value: 2.46e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446913653  28 KLSEMVEEELEQMIRRREFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINNGERARVS 93
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 16-257 4.52e-146

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 408.26  E-value: 4.52e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653  16 GRNLRRRPLARKKLSEMVEEELEQMIRRREFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINNGERARVSRP 95
Cdd:PRK03837   1 GRNLRSRPIARKKLSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653  96 SADTIIGELSGMAKDFLS-HPGGIAHFEQLRLFFESSLVRYAAEHATDEQIDLLAKALEINSQSLDNNAAFIRSDVDFHR 174
Cdd:PRK03837  81 SADTIIGQLSGMAKDFLSqSPDGLAHLKQARLFFESSLARYAAEHATDEQIALLRKALERNSQSLGDNAAFIRSDMEFHR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653 175 VLAEIPGNPIFMAIHVALLDWLIAARPTVADqaLHEHNNVSYQQHIAIVDAIRRHDPDEADRALQSHLNSVSATWHAFGQ 254
Cdd:PRK03837 161 VIAEIPGNPIFMAIHEALLDWLIEARPEVVI--LHGHENVTLQEHIAIVDAIRAHDPDEADRALQSHLNRVSALYHALGQ 238


                 ...
gi 446913653 255 TAN 257
Cdd:PRK03837 239 TTN 241
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
22-251 2.95e-55

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 177.43  E-value: 2.95e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653  22 RPLARKKLSEMVEEELEQMIRRREFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINNGERARVSRPSADTII 101
Cdd:COG2186    1 KPIRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653 102 GELSGMakdFLSHPGGIAHFEQLRLFFESSLVRYAAEHATDEQIDLLAKALEINSQSLDNNAAFIRSDVDFHRVLAEIPG 181
Cdd:COG2186   81 DPLALL---LALDDASLRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAADDGEAFAEADLAFHRAIAEASG 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653 182 NPIFMAIHVALLDWLIAARPTVADQalHEHNNVSYQQHIAIVDAIRRHDPDEADRALQSHLNSVSATWHA 251
Cdd:COG2186  158 NPLLALLLESLRELLRRSVRLTLRS--PEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLRE 225
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
20-248 6.81e-31

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 114.25  E-value: 6.81e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653  20 RRRPLARKKLSEMVEEELEQMIRRREFGEGEQLpSERELMAFFNVGRPSVREALAALKRKGLVQINNGERARVSRPSADT 99
Cdd:COG1802    3 SPSPLRRESLAEQVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653 100 IIgELSgmakdflshpggiahfeQLRLFFESSLVRYAAEHATDEQIDLLAKALEINSQSLDNN--AAFIRSDVDFHRVLA 177
Cdd:COG1802   82 IR-ELY-----------------EVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGdvAAYLELDREFHRALV 143

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446913653 178 EIPGNPIFMAIHVALLDWLIAARptVADQALHEHNNVSYQQHIAIVDAIRRHDPDEADRALQSHLNSVSAT 248
Cdd:COG1802  144 EAAGNPRLAELLRRLRARLRRYR--RLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARER 212
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 29-92 2.17e-19

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 79.20  E-value: 2.17e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446913653   29 LSEMVEEELEQMIRRREFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINNGERARV 92
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
33-92 4.19e-18

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 75.69  E-value: 4.19e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653    33 VEEELEQMIRRREFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINNGERARV 92
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 123-244 4.45e-18

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 77.79  E-value: 4.45e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653   123 QLRLFFESSLVRYAAEHATDEQIDLLAKAL---EINSQSLDNNAAFIRSDVDFHRVLAEIPGNPIFMAIHVALLDWLIAA 199
Cdd:smart00895   4 EVRRALEPLAARLAAERATDEDLAALEALLdamEAAAAAGDDLEEFAELDREFHRALAEAAGNPVLLELLESLRARLRRL 83

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 446913653   200 RPTVADQALHEHnnvsyQQHIAIVDAIRRHDPDEADRALQSHLNS 244
Cdd:smart00895  84 RRLSLEAARRAL-----DEHRAILDAIRARDAEAARAAMREHLEA 123
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 27-260 6.99e-17

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 77.50  E-value: 6.99e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653  27 KKLSEMVEEELEQMIRRREFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINNGE----RARVSRPSADTIIG 102
Cdd:PRK10421   1 RRLSDEVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGgtfiRWRHETWSEQNIVQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653 103 ELSG-MAKDflshPGGIAHFEQLRLFFESSLVRYAAEHATDEQIDLLAKALEINSQSLDNNAAfiRSDVDFHRVLAEIPG 181
Cdd:PRK10421  81 PLKTlMADD----PDYSFDILEARHAIEASTAWHAAMRATPGDKEKIQLCFEATLSEDPDLAS--QADVRFHLAIAEASH 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653 182 NPIFMAIHVALLDWLIAA----------RPTVADQaLHEhnnvsyqQHIAIVDAIRRHDPDEADRALQSHLNSVSATWHA 251
Cdd:PRK10421 155 NVVLLQTMRGFFDVLQSSvkqsrqrmylVPPVFSQ-LTE-------QHQAVMDAILAGDAEGARKAMMAHLSFVHTTIKR 226


                 ....*....
gi 446913653 252 FGQTANKKK 260
Cdd:PRK10421 227 FDEDQARQA 235
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 28-93 2.46e-16

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 71.32  E-value: 2.46e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446913653  28 KLSEMVEEELEQMIRRREFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINNGERARVS 93
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
29-154 4.00e-15

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 72.59  E-value: 4.00e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653  29 LSEMVEEELEQMIRRREFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINNGERARVSRPSADTIIGELSGMA 108
Cdd:COG2188    6 LYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTSFT 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 446913653 109 KDFLSHpgGIAHfeqlrlffESSLVRYAAEHATDEqidlLAKALEI 154
Cdd:COG2188   86 EELRAR--GREP--------STRVLSAERVPADEE----VAEALGL 117
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 123-240 7.95e-14

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 66.24  E-value: 7.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653  123 QLRLFFESSLVRYAAEHATDEQIDLLAKALEINSQSLDNN--AAFIRSDVDFHRVLAEIPGNPIFMAIHVALLDWLIAAR 200
Cdd:pfam07729   4 ELRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGdlEAFAEADREFHLALAEAAGNPVLARMLESLWDRLRRLR 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 446913653  201 PTVAdqALHEHNNVSYQQHIAIVDAIRRHDPDEADRALQS 240
Cdd:pfam07729  84 RLLL--SSPGRLRASLEEHRAILDAIRARDPEAARAAMRR 121
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
28-242 1.19e-13

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 68.51  E-value: 1.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653  28 KLSEMVEEELEQMIRRREFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINNGERARVS----RPSADTIIGE 103
Cdd:PRK09464  10 KLSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQsslwQSFSDPLVEL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653 104 LSgmakdflSHPGGIAHFEQLRLFFESSLVRYAAEHATDEQID-LLAKALEI-NSQSLDNNAAFIRSDVDFHRVLAEIPG 181
Cdd:PRK09464  90 LS-------DHPESQFDLLETRHALEGIAAYYAALRGTDEDFErIRECHHAIeLAQQSGDLDAEANAVMQYQIAVTEAAH 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653 182 NpifmaihVALLDWLIAARPTVAD------QALHEHNNVSYQ--QHIA-IVDAIRRHDPDEADRALQSHL 242
Cdd:PRK09464 163 N-------VVLLHLLRCMEPMLEQnvrqnfELLYRRREMLPKvsSHRArIFEAIVAGKPEKAREASHRHL 225
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 25-248 8.79e-13

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 65.94  E-value: 8.79e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653  25 ARKKLSEMVEEELEQMIRRREFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINNGERARVSRPSADTiigEL 104
Cdd:PRK09990   4 ERRPIADVVAERIERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVARLNRVQ---DA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653 105 SGMAKDFLSHPGGIAHFEQLRLFFESSLVRYAAEHATDEQIDLLAK------ALEINSQSLDnNAAFIRSDVDFHRVLAE 178
Cdd:PRK09990  81 SPLMHLFSSQPRTLYDLLEVRALLEGESARLAALRGTQADFVLITRryeemlAAHENNKEID-PIEHARLDHAFHLAICE 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446913653 179 IPGNPIFMAIHVALLDWLIAARPTVADQALHE--HNNVSYQQHIAIVDAIRRHDPDEADRALQSHLNSVSAT 248
Cdd:PRK09990 160 ASHNPVLVHTLQSLTDLMLSSVFASVNNLYHRpqQKKQIDRQHARLYNAVLQRLPEQAQRAARDHIRTVRDN 231
PRK10225 PRK10225
Uxu operon transcriptional regulator;
37-245 9.31e-13

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 66.20  E-value: 9.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653  37 LEQMIRRREFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINNGERARVSRPSADTiigELSGMAKDFLSHPG 116
Cdd:PRK10225  18 IRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSH---NTDSPDANVCNDAG 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653 117 giaHFEQL--RLFFESSLVRYAAEHATDEQIDLLAKALEINSQSLDNNA--AFIRSDVDFHRVLAEIPGNPifMAIHVAL 192
Cdd:PRK10225  95 ---PFELLqaRQLLESNIAEFAALQATREDIVKMRQALQLEERELASSApgSSESGDMQFHLAIAEATHNS--MLVELFR 169

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446913653 193 LDWLIAARPTVADQaLHEH-NNVSYQQ-----HIAIVDAIRRHDPDEADRALQSHLNSV 245
Cdd:PRK10225 170 QSWQWRENNPMWIQ-LHSHlDDSLYRKewlgdHKQILAALIKKDARAAKLAMWQHLENV 227
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 25-148 4.08e-06

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 47.52  E-value: 4.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653  25 ARKKLSEMVEEELEQMIRRREFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINNG------ERARVSRPSAD 98
Cdd:COG1167    9 SSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGsgtfvaARLPAPAPAPR 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446913653  99 TIIGELSGMAKDFLSHPGGIAHFE----QLRLFFESSLVRYAAEHATDEQIDLL 148
Cdd:COG1167   89 AAAAVAAPALRRLLEAAPGVIDLGsgapDPDLFPLAALRRALRRALRRLPPALL 142
PRK04984 PRK04984
fatty acid metabolism transcriptional regulator FadR;
46-188 5.14e-06

fatty acid metabolism transcriptional regulator FadR;


Pssm-ID: 179909 [Multi-domain]  Cd Length: 239  Bit Score: 46.40  E-value: 5.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653  46 FGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINNGERARVSRpsadtiIGELSG-------MAKDFLSHPGGI 118
Cdd:PRK04984  25 FPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNN------FWETSGlniletlARLDHDSVPQLI 98

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446913653 119 AHFEQLRLFFESSLVRYAAEHATDEQIDLLAKAleinsQSLDNNA-AFIRSDVDFHRVLAEIPGNPIFMAI 188
Cdd:PRK04984  99 DNLLSARTNISAIFIRTAFRNNPEKALEVLATA-----EELEDTAeAFAEFDYNLFRGLAFASGNPIYGLI 164
PRK11523 PRK11523
transcriptional regulator ExuR;
27-242 1.39e-05

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 45.22  E-value: 1.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653  27 KKLSEMVEEELEQMIRRREFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINNGERARV--SRPSADTIigel 104
Cdd:PRK11523   7 RRLYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVvsNQPRHQQA---- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653 105 SGMAKDFLSHpgGIAHFEQLRLFFESSLVRYAAEHATDEQIDLLakaLEINSQSlDNNAAFIRS--DVDFHRVLAEIPGN 182
Cdd:PRK11523  83 ADNNMEFANY--GPFELLQARQLIESNIAEFAATQVTKQDIMKL---MAIQEQA-RGEDCFRDSewDLQFHVQVALATQN 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446913653 183 PIFMAIHVALldWLIAARPTVAdQALHEHNN----VSY-QQHIAIVDAIRRHDPDEADRALQSHL 242
Cdd:PRK11523 157 SALAAIVEKM--WTQRSHNPYW-KKLHEHIDdrtvDNWcDDHDQILKALIRKDPHAAKLAMWQHL 218
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
35-82 5.83e-05

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 41.32  E-value: 5.83e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 446913653  35 EELEQMIRRREFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLV 82
Cdd:COG1725   17 DQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLI 64
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 18-87 4.66e-04

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 40.53  E-value: 4.66e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446913653  18 NLRRRPLARKKLSEMVEEELEQMIRRReFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINNG 87
Cdd:PRK10079   2 HLSRHPTSYPTRYQEIAAKLEQELRQH-YRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQG 70
PRK09764 PRK09764
GntR family transcriptional regulator;
24-76 7.89e-04

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 39.81  E-value: 7.89e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446913653  24 LARKKLSEMVEEELEQMIRRREFGEGEQLPSERELMAFFNVGRPSVREALAAL 76
Cdd:PRK09764   1 MGHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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