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Conserved domains on  [gi|446906631|ref|WP_000983887|]
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MULTISPECIES: bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF [Escherichia]

Protein Classification

bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase( domain architecture ID 11484157)

bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase catalyzes the fourth and fifth steps of tryptophan biosynthesis

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK09427 PRK09427
bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase ...
1-453 0e+00

bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF;


:

Pssm-ID: 236509 [Multi-domain]  Cd Length: 454  Bit Score: 935.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631   1 MMQTVLAKIVADKAIWVETRKEQQPLASFQNEVQPSTRHFYDALQGARTSFILECKKASPSKGVIRDDFDPARIAAIYKH 80
Cdd:PRK09427   2 MMPTVLAKIVADKAIWVAARKQQQPLASFQNEIQPSDRSFYDALKGPKTAFILECKKASPSKGLIRDDFDPAEIARVYKH 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631  81 YASAISVLTDEKYFQGSFDFLPIVSQIAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDEQYRQLAAVAHSLEMG 160
Cdd:PRK09427  82 YASAISVLTDEKYFQGSFDFLPIVRAIVTQPILCKDFIIDPYQIYLARYYGADAILLMLSVLDDEQYRQLAAVAHSLNMG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 161 VLTEVSNEEELERAIALGAKVVGINNRDLRDLSIDLNRTRELAPKLGHNVTVISESGINTYAQVRELSHFANGFLIGSAL 240
Cdd:PRK09427 162 VLTEVSNEEELERAIALGAKVIGINNRNLRDLSIDLNRTRELAPLIPADVIVISESGIYTHAQVRELSPFANGFLIGSSL 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 241 MAHDDLNAAVRRVLLGENKVCGLTRGQDAKAAYDAGAIYGGLIFVATSPRCVNVEQAQEVMAAAPLQYVGVFRNHDIADV 320
Cdd:PRK09427 242 MAEDDLELAVRKLILGENKVCGLTRPQDAKAAYDAGAVYGGLIFVEKSPRYVSLEQAQEIIAAAPLRYVGVFRNADIEDI 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 321 VDKAKVLSLAAVQLHGNEDQQYIDTLRGALPANIAIWKALSVGETLPARELQHVDKYVLDNGQGGSGQRFDWSLLNGQSL 400
Cdd:PRK09427 322 VDIAKQLSLAAVQLHGDEDQAYIDALREALPKTCQIWKAISVGDTLPARDLQHVDRYLLDNGQGGTGQTFDWSLLPGQSL 401
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446906631 401 GNVLLAGGLGADNCVEAAQTGCAGLDFNSAVESQPGIKDARLLASVFQTLRAY 453
Cdd:PRK09427 402 DNVLLAGGLNPDNCQQAAQLGCAGLDFNSGVESAPGIKDAQKLASVFQTLRAY 454
 
Name Accession Description Interval E-value
PRK09427 PRK09427
bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase ...
1-453 0e+00

bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF;


Pssm-ID: 236509 [Multi-domain]  Cd Length: 454  Bit Score: 935.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631   1 MMQTVLAKIVADKAIWVETRKEQQPLASFQNEVQPSTRHFYDALQGARTSFILECKKASPSKGVIRDDFDPARIAAIYKH 80
Cdd:PRK09427   2 MMPTVLAKIVADKAIWVAARKQQQPLASFQNEIQPSDRSFYDALKGPKTAFILECKKASPSKGLIRDDFDPAEIARVYKH 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631  81 YASAISVLTDEKYFQGSFDFLPIVSQIAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDEQYRQLAAVAHSLEMG 160
Cdd:PRK09427  82 YASAISVLTDEKYFQGSFDFLPIVRAIVTQPILCKDFIIDPYQIYLARYYGADAILLMLSVLDDEQYRQLAAVAHSLNMG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 161 VLTEVSNEEELERAIALGAKVVGINNRDLRDLSIDLNRTRELAPKLGHNVTVISESGINTYAQVRELSHFANGFLIGSAL 240
Cdd:PRK09427 162 VLTEVSNEEELERAIALGAKVIGINNRNLRDLSIDLNRTRELAPLIPADVIVISESGIYTHAQVRELSPFANGFLIGSSL 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 241 MAHDDLNAAVRRVLLGENKVCGLTRGQDAKAAYDAGAIYGGLIFVATSPRCVNVEQAQEVMAAAPLQYVGVFRNHDIADV 320
Cdd:PRK09427 242 MAEDDLELAVRKLILGENKVCGLTRPQDAKAAYDAGAVYGGLIFVEKSPRYVSLEQAQEIIAAAPLRYVGVFRNADIEDI 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 321 VDKAKVLSLAAVQLHGNEDQQYIDTLRGALPANIAIWKALSVGETLPARELQHVDKYVLDNGQGGSGQRFDWSLLNGQSL 400
Cdd:PRK09427 322 VDIAKQLSLAAVQLHGDEDQAYIDALREALPKTCQIWKAISVGDTLPARDLQHVDRYLLDNGQGGTGQTFDWSLLPGQSL 401
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446906631 401 GNVLLAGGLGADNCVEAAQTGCAGLDFNSAVESQPGIKDARLLASVFQTLRAY 453
Cdd:PRK09427 402 DNVLLAGGLNPDNCQQAAQLGCAGLDFNSGVESAPGIKDAQKLASVFQTLRAY 454
IGPS pfam00218
Indole-3-glycerol phosphate synthase;
6-252 5.36e-136

Indole-3-glycerol phosphate synthase;


Pssm-ID: 395163  Cd Length: 252  Bit Score: 390.89  E-value: 5.36e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631    6 LAKIVADKAIWVETRKEQQPLASFQNEV-QPSTRHFYDALQGA--RTSFILECKKASPSKGVIRDDFDPARIAAIYKHY- 81
Cdd:pfam00218   1 LEKIVADKRAEVAARKARPPLADLQAAArAPPTRSFYDALRESrgRPALIAEVKKASPSKGLIREDFDPAEIARVYEAAg 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631   82 ASAISVLTDEKYFQGSFDFLPIVSQIAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDEQYRQLAAVAHSLEMGV 161
Cdd:pfam00218  81 ASAISVLTDPKYFQGSIEYLRAVRQAVSLPVLRKDFIIDEYQIDEARLAGADAILLIVAVLDDELLEELYAYARSLGMEV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631  162 LTEVSNEEELERAIALGAKVVGINNRDLRDLSIDLNRTRELAPKLGHNVTVISESGINTYAQVRELS-HFANGFLIGSAL 240
Cdd:pfam00218 161 LVEVHNEEELERALALGAKIIGVNNRNLKTFEVDLNTTRRLAPLIPADVLLVAESGIYTPADVRELKeHGANAFLVGESL 240
                         250
                  ....*....|..
gi 446906631  241 MAHDDLNAAVRR 252
Cdd:pfam00218 241 MRQEDVRAAIRE 252
TrpC COG0134
Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol ...
3-254 8.38e-133

Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439904  Cd Length: 257  Bit Score: 383.22  E-value: 8.38e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631   3 QTVLAKIVADKAIWVETRKEQQPLASFQNEV--QPSTRHFYDALQGA-RTSFILECKKASPSKGVIRDDFDPARIAAIYK 79
Cdd:COG0134    1 PTILDKIVAHKREEVAARKARVPLAELEARAaaAPPPRDFAAALRAAgGPAVIAEIKKASPSKGLIREDFDPAEIARAYE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631  80 HY-ASAISVLTDEKYFQGSFDFLPIVSQIAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDEQYRQLAAVAHSLE 158
Cdd:COG0134   81 AGgAAAISVLTDEKFFQGSLEDLRAVRAAVDLPVLRKDFIIDPYQIYEARAAGADAILLIAAALDDEQLKELLALAHSLG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 159 MGVLTEVSNEEELERAIALGAKVVGINNRDLRDLSIDLNRTRELAPKLGHNVTVISESGINTYAQVREL-SHFANGFLIG 237
Cdd:COG0134  161 MDVLVEVHDEEELERALALGARLIGINNRNLKTFEVDLETTERLAPLIPADVLVVSESGIRTPEDVARLaAAGADAFLVG 240
                        250
                 ....*....|....*..
gi 446906631 238 SALMAHDDLNAAVRRVL 254
Cdd:COG0134  241 EALMRAPDPGAALRELL 257
IGPS cd00331
Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, ...
40-253 3.45e-108

Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the release of carbon dioxide and water. IGPS is active as a separate monomer in most organisms, but is also found fused to other enzymes as part of a bifunctional or multifunctional enzyme involved in tryptophan biosynthesis.


Pssm-ID: 238203  Cd Length: 217  Bit Score: 319.02  E-value: 3.45e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631  40 FYDALQGA-RTSFILECKKASPSKGVIRDDFDPARIAAIYKHY-ASAISVLTDEKYFQGSFDFLPIVSQIAPQPILCKDF 117
Cdd:cd00331    1 FKAALKRPgGLGVIAEVKRASPSKGLIREDFDPVEIAKAYEKAgAAAISVLTEPKYFQGSLEDLRAVREAVSLPVLRKDF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 118 IIDPYQIYLARYYQADACLLMLSVLDDEQYRQLAAVAHSLEMGVLTEVSNEEELERAIALGAKVVGINNRDLRDLSIDLN 197
Cdd:cd00331   81 IIDPYQIYEARAAGADAVLLIVAALDDEQLKELYELARELGMEVLVEVHDEEELERALALGAKIIGINNRDLKTFEVDLN 160
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446906631 198 RTRELAPKLGHNVTVISESGINTYAQVREL-SHFANGFLIGSALMAHDDLNAAVRRV 253
Cdd:cd00331  161 TTERLAPLIPKDVILVSESGISTPEDVKRLaEAGADAVLIGESLMRAPDPGAALREL 217
 
Name Accession Description Interval E-value
PRK09427 PRK09427
bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase ...
1-453 0e+00

bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF;


Pssm-ID: 236509 [Multi-domain]  Cd Length: 454  Bit Score: 935.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631   1 MMQTVLAKIVADKAIWVETRKEQQPLASFQNEVQPSTRHFYDALQGARTSFILECKKASPSKGVIRDDFDPARIAAIYKH 80
Cdd:PRK09427   2 MMPTVLAKIVADKAIWVAARKQQQPLASFQNEIQPSDRSFYDALKGPKTAFILECKKASPSKGLIRDDFDPAEIARVYKH 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631  81 YASAISVLTDEKYFQGSFDFLPIVSQIAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDEQYRQLAAVAHSLEMG 160
Cdd:PRK09427  82 YASAISVLTDEKYFQGSFDFLPIVRAIVTQPILCKDFIIDPYQIYLARYYGADAILLMLSVLDDEQYRQLAAVAHSLNMG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 161 VLTEVSNEEELERAIALGAKVVGINNRDLRDLSIDLNRTRELAPKLGHNVTVISESGINTYAQVRELSHFANGFLIGSAL 240
Cdd:PRK09427 162 VLTEVSNEEELERAIALGAKVIGINNRNLRDLSIDLNRTRELAPLIPADVIVISESGIYTHAQVRELSPFANGFLIGSSL 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 241 MAHDDLNAAVRRVLLGENKVCGLTRGQDAKAAYDAGAIYGGLIFVATSPRCVNVEQAQEVMAAAPLQYVGVFRNHDIADV 320
Cdd:PRK09427 242 MAEDDLELAVRKLILGENKVCGLTRPQDAKAAYDAGAVYGGLIFVEKSPRYVSLEQAQEIIAAAPLRYVGVFRNADIEDI 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 321 VDKAKVLSLAAVQLHGNEDQQYIDTLRGALPANIAIWKALSVGETLPARELQHVDKYVLDNGQGGSGQRFDWSLLNGQSL 400
Cdd:PRK09427 322 VDIAKQLSLAAVQLHGDEDQAYIDALREALPKTCQIWKAISVGDTLPARDLQHVDRYLLDNGQGGTGQTFDWSLLPGQSL 401
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446906631 401 GNVLLAGGLGADNCVEAAQTGCAGLDFNSAVESQPGIKDARLLASVFQTLRAY 453
Cdd:PRK09427 402 DNVLLAGGLNPDNCQQAAQLGCAGLDFNSGVESAPGIKDAQKLASVFQTLRAY 454
IGPS pfam00218
Indole-3-glycerol phosphate synthase;
6-252 5.36e-136

Indole-3-glycerol phosphate synthase;


Pssm-ID: 395163  Cd Length: 252  Bit Score: 390.89  E-value: 5.36e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631    6 LAKIVADKAIWVETRKEQQPLASFQNEV-QPSTRHFYDALQGA--RTSFILECKKASPSKGVIRDDFDPARIAAIYKHY- 81
Cdd:pfam00218   1 LEKIVADKRAEVAARKARPPLADLQAAArAPPTRSFYDALRESrgRPALIAEVKKASPSKGLIREDFDPAEIARVYEAAg 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631   82 ASAISVLTDEKYFQGSFDFLPIVSQIAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDEQYRQLAAVAHSLEMGV 161
Cdd:pfam00218  81 ASAISVLTDPKYFQGSIEYLRAVRQAVSLPVLRKDFIIDEYQIDEARLAGADAILLIVAVLDDELLEELYAYARSLGMEV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631  162 LTEVSNEEELERAIALGAKVVGINNRDLRDLSIDLNRTRELAPKLGHNVTVISESGINTYAQVRELS-HFANGFLIGSAL 240
Cdd:pfam00218 161 LVEVHNEEELERALALGAKIIGVNNRNLKTFEVDLNTTRRLAPLIPADVLLVAESGIYTPADVRELKeHGANAFLVGESL 240
                         250
                  ....*....|..
gi 446906631  241 MAHDDLNAAVRR 252
Cdd:pfam00218 241 MRQEDVRAAIRE 252
TrpC COG0134
Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol ...
3-254 8.38e-133

Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439904  Cd Length: 257  Bit Score: 383.22  E-value: 8.38e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631   3 QTVLAKIVADKAIWVETRKEQQPLASFQNEV--QPSTRHFYDALQGA-RTSFILECKKASPSKGVIRDDFDPARIAAIYK 79
Cdd:COG0134    1 PTILDKIVAHKREEVAARKARVPLAELEARAaaAPPPRDFAAALRAAgGPAVIAEIKKASPSKGLIREDFDPAEIARAYE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631  80 HY-ASAISVLTDEKYFQGSFDFLPIVSQIAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDEQYRQLAAVAHSLE 158
Cdd:COG0134   81 AGgAAAISVLTDEKFFQGSLEDLRAVRAAVDLPVLRKDFIIDPYQIYEARAAGADAILLIAAALDDEQLKELLALAHSLG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 159 MGVLTEVSNEEELERAIALGAKVVGINNRDLRDLSIDLNRTRELAPKLGHNVTVISESGINTYAQVREL-SHFANGFLIG 237
Cdd:COG0134  161 MDVLVEVHDEEELERALALGARLIGINNRNLKTFEVDLETTERLAPLIPADVLVVSESGIRTPEDVARLaAAGADAFLVG 240
                        250
                 ....*....|....*..
gi 446906631 238 SALMAHDDLNAAVRRVL 254
Cdd:COG0134  241 EALMRAPDPGAALRELL 257
trpC PRK00278
indole-3-glycerol phosphate synthase TrpC;
2-257 2.97e-110

indole-3-glycerol phosphate synthase TrpC;


Pssm-ID: 234710  Cd Length: 260  Bit Score: 325.96  E-value: 2.97e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631   2 MQTVLAKIVADKAIWVETRKEQQPLASFQNEV--QPSTRHFYDALQGARTSFILECKKASPSKGVIRDDFDPARIAAIY- 78
Cdd:PRK00278   1 MMDILDKIVAYKREEVAARKAQVPLAELKARAaaAPPPRDFAAALRAGKPAVIAEVKKASPSKGVIREDFDPVEIAKAYe 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631  79 KHYASAISVLTDEKYFQGSFDFLPIVSQIAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDEQYRQLAAVAHSLE 158
Cdd:PRK00278  81 AGGAACLSVLTDERFFQGSLEYLRAARAAVSLPVLRKDFIIDPYQIYEARAAGADAILLIVAALDDEQLKELLDYAHSLG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 159 MGVLTEVSNEEELERAIALGAKVVGINNRDLRDLSIDLNRTRELAPKLGHNVTVISESGINTYAQVREL-SHFANGFLIG 237
Cdd:PRK00278 161 LDVLVEVHDEEELERALKLGAPLIGINNRNLKTFEVDLETTERLAPLIPSDRLVVSESGIFTPEDLKRLaKAGADAVLVG 240
                        250       260
                 ....*....|....*....|
gi 446906631 238 SALMAHDDLNAAVRRVLLGE 257
Cdd:PRK00278 241 ESLMRADDPGAALRELLGAK 260
IGPS cd00331
Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, ...
40-253 3.45e-108

Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the release of carbon dioxide and water. IGPS is active as a separate monomer in most organisms, but is also found fused to other enzymes as part of a bifunctional or multifunctional enzyme involved in tryptophan biosynthesis.


Pssm-ID: 238203  Cd Length: 217  Bit Score: 319.02  E-value: 3.45e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631  40 FYDALQGA-RTSFILECKKASPSKGVIRDDFDPARIAAIYKHY-ASAISVLTDEKYFQGSFDFLPIVSQIAPQPILCKDF 117
Cdd:cd00331    1 FKAALKRPgGLGVIAEVKRASPSKGLIREDFDPVEIAKAYEKAgAAAISVLTEPKYFQGSLEDLRAVREAVSLPVLRKDF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 118 IIDPYQIYLARYYQADACLLMLSVLDDEQYRQLAAVAHSLEMGVLTEVSNEEELERAIALGAKVVGINNRDLRDLSIDLN 197
Cdd:cd00331   81 IIDPYQIYEARAAGADAVLLIVAALDDEQLKELYELARELGMEVLVEVHDEEELERALALGAKIIGINNRDLKTFEVDLN 160
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446906631 198 RTRELAPKLGHNVTVISESGINTYAQVREL-SHFANGFLIGSALMAHDDLNAAVRRV 253
Cdd:cd00331  161 TTERLAPLIPKDVILVSESGISTPEDVKRLaEAGADAVLIGESLMRAPDPGAALREL 217
PRAI pfam00697
N-(5'phosphoribosyl)anthranilate (PRA) isomerase;
258-448 2.31e-82

N-(5'phosphoribosyl)anthranilate (PRA) isomerase;


Pssm-ID: 395566  Cd Length: 193  Bit Score: 251.88  E-value: 2.31e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631  258 NKVCGLTRGQDAKAAYDAGAIYGGLIFVATSPRCVNVEQAQEVMAAAPLQYVGVFRNHDIADVVDKAKVLSLAAVQLHGN 337
Cdd:pfam00697   1 AKICGLTRLSDVKAAVKAGADYLGLIFSESSKRQVSPEQAQELRSPVPLLLVGVFVNQPIDDVLRIAQVLGLDVVQLHGD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631  338 EDQQYIDTLRGALPANIAIWKALSVGETLPARELQHVDKYVLDNGQGGSGQRFDWSLLNGQSL--GNVLLAGGLGADNCV 415
Cdd:pfam00697  81 EDQEYENLLPTGVPVIKAIWVPDSVDTVDIARRADHVDLPLLDSGAGGTGELFDWSLVSKWLKsgLKVILAGGLNPDNVV 160
                         170       180       190
                  ....*....|....*....|....*....|....
gi 446906631  416 EAAQT-GCAGLDFNSAVESQpGIKDARLLASVFQ 448
Cdd:pfam00697 161 EAIKTpGVIGVDVSSGVETN-GIKDLNKIRKFVQ 193
TrpF COG0135
Phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; ...
258-452 1.67e-73

Phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Phosphoribosylanthranilate isomerase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439905  Cd Length: 208  Bit Score: 229.64  E-value: 1.67e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 258 NKVCGLTRGQDAKAAYDAGAIYGGLIFVATSPRCVNVEQAQEVMAAAP--LQYVGVFRNHDIADVVDKAKVLSLAAVQLH 335
Cdd:COG0135    4 VKICGLTRPEDARAAVEAGADALGFVFYPKSPRYVSPEQAAELAAALPpfVKKVGVFVNADPEEILEIVEAVGLDAVQLH 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 336 GNEDQQYIDTLRgaLPANIAIWKALSVGETLPAREL----QHVDKYVLD----NGQGGSGQRFDWSLLNGQSLG-NVLLA 406
Cdd:COG0135   84 GDESPEYCAALR--ERLGLPVIKAIRVGDGADLEEAaayaPVADALLLDakvpGLYGGTGKTFDWSLLAGLALPkPVILA 161
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 446906631 407 GGLGADNCVEA-AQTGCAGLDFNSAVESQPGIKDARLLASVFQTLRA 452
Cdd:COG0135  162 GGLTPENVAEAiRLVRPYGVDVSSGVESAPGVKDPDKIRAFVEAVRA 208
PRAI cd00405
Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan ...
258-448 6.66e-69

Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric, monofunctional and thermolabile, but in some thermophile organisms PRAI is dimeric for reasons of stability and in others it is fused to other components of the tryptophan biosynthesis pathway to form multifunctional enzymes.


Pssm-ID: 238237  Cd Length: 203  Bit Score: 217.83  E-value: 6.66e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 258 NKVCGLTRGQDAKAAYDAGAIYGGLIFVATSPRCVNVEQAQEVMAAAP--LQYVGVFRNHDIADVVDKAKVLSLAAVQLH 335
Cdd:cd00405    1 VKICGITTLEDALAAAEAGADAIGFIFAPKSPRYVSPEQAREIVAALPpfVKRVGVFVNEDLEEILEIAEELGLDVVQLH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 336 GNEDQQYIDTLRGALpaNIAIWKALSVGETLP----ARELQHVDKYVLDN----GQGGSGQRFDWSLLNGQSLG-NVLLA 406
Cdd:cd00405   81 GDESPEYCAQLRARL--GLPVIKAIRVKDEEDlekaAAYAGEVDAILLDSksggGGGGTGKTFDWSLLRGLASRkPVILA 158
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 446906631 407 GGLGADNCVEA-AQTGCAGLDFNSAVESQPGIKDARLLASVFQ 448
Cdd:cd00405  159 GGLTPDNVAEAiRLVRPYGVDVSSGVETSPGIKDPEKIRAFIE 201
PLN02460 PLN02460
indole-3-glycerol-phosphate synthase
3-250 4.83e-63

indole-3-glycerol-phosphate synthase


Pssm-ID: 215254  Cd Length: 338  Bit Score: 207.32  E-value: 4.83e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631   3 QTVLAKIVADKAIWVETRKEQQPLASFQNEVQ--PSTRHFYDALQGA--RTSF---ILECKKASPSKGVIRDDFDPARIA 75
Cdd:PLN02460  66 RNILEEIVWYKDVEVAQMKERKPLYLLKKALQnaPPARDFVGALRAAhkRTGQpglIAEVKKASPSRGVLRENFDPVEIA 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631  76 AIY-KHYASAISVLTDEKYFQGSFDFLPIVSQIAPQ-PILCKDFIIDPYQIYLARYYQADACLLMLSVLDDEQYRQLAAV 153
Cdd:PLN02460 146 QAYeKGGAACLSVLTDEKYFQGSFENLEAIRNAGVKcPLLCKEFIVDAWQIYYARSKGADAILLIAAVLPDLDIKYMLKI 225
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 154 AHSLEMGVLTEVSNEEELERAIAL-GAKVVGINNRDLRDLSIDLNRTREL-APKLGH-----NVTVISESGINT---YAQ 223
Cdd:PLN02460 226 CKSLGMAALIEVHDEREMDRVLGIeGVELIGINNRSLETFEVDISNTKKLlEGERGEqirekGIIVVGESGLFTpddVAY 305
                        250       260
                 ....*....|....*....|....*..
gi 446906631 224 VRELSHFAngFLIGSALMAHDDLNAAV 250
Cdd:PLN02460 306 VQNAGVKA--VLVGESLVKQDDPGKGI 330
PRK01222 PRK01222
phosphoribosylanthranilate isomerase;
259-453 3.99e-49

phosphoribosylanthranilate isomerase;


Pssm-ID: 234923  Cd Length: 210  Bit Score: 166.52  E-value: 3.99e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 259 KVCGLTRGQDAKAAYDAGAIYGGLIFVATSPRCVNVEQAQEVMAAAP--LQYVGVFRNHDIADVVDKAKVLSLAAVQLHG 336
Cdd:PRK01222   6 KICGITTPEDAEAAAELGADAIGFVFYPKSPRYVSPEQAAELAAALPpfVKVVGVFVNASDEEIDEIVETVPLDLLQLHG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 337 NEDQQYIDTLRGALpaNIAIWKALSVGETLPARELQH----VDKYVLD---NGQGGSGQRFDWSLLNGQSLGNVLLAGGL 409
Cdd:PRK01222  86 DETPEFCRQLKRRY--GLPVIKALRVRSAGDLEAAAAyygdADGLLLDayvGLPGGTGKTFDWSLLPAGLAKPWILAGGL 163
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 446906631 410 GADNCVEA-AQTGCAGLDFNSAVESQPGIKDARLLASVFQTLRAY 453
Cdd:PRK01222 164 NPDNVAEAiRQVRPYGVDVSSGVESAPGIKDPEKIRAFIEAVKSA 208
PRK13957 PRK13957
indole-3-glycerol-phosphate synthase; Provisional
2-249 2.04e-48

indole-3-glycerol-phosphate synthase; Provisional


Pssm-ID: 140013  Cd Length: 247  Bit Score: 166.21  E-value: 2.04e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631   2 MQTVLAKIVADKAIWVETRKEQQPLASFQNEVQpstrhfyDALQGARTSFILECKKASPSKGVIRDDFDPARIAAIYKHY 81
Cdd:PRK13957   1 MHRVLREIIETKQNEIEKISRWDPLPDRGLPLR-------DSLKSRSFSIIAECKRKSPSAGELRADYHPVQIAKTYETL 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631  82 -ASAISVLTDEKYFQGSFDFLPIVSQIAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDEQYRQLAAVAHSLEMG 160
Cdd:PRK13957  74 gASAISVLTDQSYFGGSLEDLKSVSSELKIPVLRKDFILDEIQIREARAFGASAILLIVRILTPSQIKSFLKHASSLGMD 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 161 VLTEVSNEEELERAIALGAKVVGINNRDLRDLSIDLNRTRELAPKLGHNVTVISESGINTYAQVRELSHFANGFLIGSAL 240
Cdd:PRK13957 154 VLVEVHTEDEAKLALDCGAEIIGINTRDLDTFQIHQNLVEEVAAFLPPNIVKVGESGIESRSDLDKFRKLVDAALIGTYF 233

                 ....*....
gi 446906631 241 MAHDDLNAA 249
Cdd:PRK13957 234 MEKKDIRKA 242
PRK13802 PRK13802
bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional
52-254 1.05e-45

bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional


Pssm-ID: 184335 [Multi-domain]  Cd Length: 695  Bit Score: 168.67  E-value: 1.05e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631  52 ILECKKASPSKGVIRDDFDPARIAAIY-KHYASAISVLTDEKYFQGSFDFLPIVSQIAPQPILCKDFIIDPYQIYLARYY 130
Cdd:PRK13802  53 IAEIKRASPSKGHLSDIPDPAALAREYeQGGASAISVLTEGRRFLGSLDDFDKVRAAVHIPVLRKDFIVTDYQIWEARAH 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 131 QADACLLMLSVLDDEQYRQLAAVAHSLEMGVLTEVSNEEELERAIALGAKVVGINNRDLRDLSIDLNRTRELAPKLGHNV 210
Cdd:PRK13802 133 GADLVLLIVAALDDAQLKHLLDLAHELGMTVLVETHTREEIERAIAAGAKVIGINARNLKDLKVDVNKYNELAADLPDDV 212
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 446906631 211 TVISESGINTYAQVRELSHF-ANGFLIGSALMAHDDLNAAVRRVL 254
Cdd:PRK13802 213 IKVAESGVFGAVEVEDYARAgADAVLVGEGVATADDHELAVERLV 257
PLN02363 PLN02363
phosphoribosylanthranilate isomerase
259-440 6.58e-26

phosphoribosylanthranilate isomerase


Pssm-ID: 215207  Cd Length: 256  Bit Score: 105.71  E-value: 6.58e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 259 KVCGLTRGQDAKAAYDAGAIYGGLIFVATSPRCVNVEQAQEVMAAAP---LQYVGVFRNHDIADVVDKAKVLSLAAVQLH 335
Cdd:PLN02363  50 KMCGITSARDAAMAVEAGADFIGMILWPKSKRSISLSVAKEISQVAReggAKPVGVFVDDDANTILRAADSSDLELVQLH 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 336 GNEDQQYIDTLRGALPAnIAIWKALSVGETL---PARELQHVDKYVLDNGQGGSGQRFDWS---LLNGQSLGNVLLAGGL 409
Cdd:PLN02363 130 GNGSRAAFSRLVRERKV-IYVLNANEDGKLLnvvPEEDCHLADWILVDSATGGSGKGFNWQnfkLPSVRSRNGWLLAGGL 208
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 446906631 410 GADNCVEAAqtgCA----GLDFNSAVESQPGI-KDA 440
Cdd:PLN02363 209 TPENVHEAV---SLlkptGVDVSSGICGPDGIrKDP 241
PRK13958 PRK13958
N-(5'-phosphoribosyl)anthranilate isomerase; Provisional
259-451 1.37e-15

N-(5'-phosphoribosyl)anthranilate isomerase; Provisional


Pssm-ID: 184418  Cd Length: 207  Bit Score: 75.15  E-value: 1.37e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 259 KVCGLTRGQDAKAAYDAGAIYGGLIFVATSPRCVNVEQAQEVMAAAP--LQYVGVFRNHDIADVVDKAKVLSLAAVQLHG 336
Cdd:PRK13958   4 KFCGFTTIKDVTAASQLPIDAIGFIHYEKSKRHQTITQIKKLASAVPnhIDKVCVVVNPDLTTIEHILSNTSINTIQLHG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 337 NEDQQYIDTLRGALPaNIAIWKALSVGETLPARELQ---HVDKYVLDNGQ---GGSGQRFDWSLLNGQSLGNVLLAGGLG 410
Cdd:PRK13958  84 TESIDFIQEIKKKYS-SIKIIKALPADENIIQNINKykgFVDLFIIDTPSvsyGGTGQTYDWTILKHIKDIPYLIAGGIN 162
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 446906631 411 ADNC--VEAAQTGCAGLDFNSAVESQpGIKDARLLASVFQTLR 451
Cdd:PRK13958 163 SENIqtVEQLKLSHQGYDIASGIETN-GRKDINKMTAIVNIVK 204
PRK13803 PRK13803
bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta; Provisional
259-451 5.43e-15

bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta; Provisional


Pssm-ID: 237513 [Multi-domain]  Cd Length: 610  Bit Score: 77.16  E-value: 5.43e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 259 KVCGLTRGQDAKAAYDAGAIYGGLIFVATSPRCVNVE-QAQEVMAAAP---LQYVGVFRNHDIADVVDKAKVLSLAAVQL 334
Cdd:PRK13803   6 KICGIKDSALISKAVDMLPDFIGFIFYEKSPRFVGNKfLAPNLEKAIRkagGRPVGVFVNESAKAMLKFSKKNGIDFVQL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 335 HGNEDQQYIDTLRGALPANIAIWKALSVGETLPAREL----QHVDKYVLDN---GQGGSGQRFDWSLLNGQSLGNV-LLA 406
Cdd:PRK13803  86 HGAESKAEPAYCQRIYKKSIKKIGSFLIDDAFGFEVLdeyrDHVKYFLFDNktkIYGGSGKSFDWEKFYNYNFKFPfFLS 165
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 446906631 407 GGLGADNCVEAAQTGCA---GLDFNSAVESQPGIKDARLLASVFQTLR 451
Cdd:PRK13803 166 GGLSPTNFDRIINLTHPqilGIDVSSGFEDSPGNKKLTLLKSFITNVK 213
TIM_phosphate_binding cd04722
TIM barrel proteins share a structurally conserved phosphate binding motif and in general ...
68-238 3.96e-14

TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate comes either from the substrate, as in the case of inosine monophosphate dehydrogenase (IMPDH), or from ribulose-5-phosphate 3-epimerase (RPE) or from cofactors, like FMN.


Pssm-ID: 240073 [Multi-domain]  Cd Length: 200  Bit Score: 71.08  E-value: 3.96e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631  68 DFDPARIAAIYKHY-ASAISVLTDEKYFQGSF----DFLPIVSQIAPQPILCKDFIIDPYQIY-----LARYYQADACLL 137
Cdd:cd04722   11 SGDPVELAKAAAEAgADAIIVGTRSSDPEEAEtddkEVLKEVAAETDLPLGVQLAINDAAAAVdiaaaAARAAGADGVEI 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446906631 138 MLSV-----LDDEQYRQLAAVAHSLEMGVLTEVSNEEELERAIALGAKVVGINNRDLRDLSIDLNRT---RELAPKLGHN 209
Cdd:cd04722   91 HGAVgylarEDLELIRELREAVPDVKVVVKLSPTGELAAAAAEEAGVDEVGLGNGGGGGGGRDAVPIadlLLILAKRGSK 170
                        170       180       190
                 ....*....|....*....|....*....|
gi 446906631 210 VTVISESGINTYAQVRELSHF-ANGFLIGS 238
Cdd:cd04722  171 VPVIAGGGINDPEDAAEALALgADGVIVGS 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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