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Conserved domains on  [gi|446897653|ref|WP_000974909|]
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MULTISPECIES: iron ABC transporter permease [Staphylococcus]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 39-339 2.19e-93

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 280.42  E-value: 2.19e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  39 MAIGSSKINFSDIIHYVTGHT-DTKATFLLHNVRMPRMIAGLFIGGALAVSGLLMQAMTRNPLASPKIFGVSSGASFFIV 117
Cdd:COG0609    2 LSLGAVPISLSDVLRALLGPDgDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 118 FVTIIIPSLEYYALYLG-VIGAFIGGLTVYTLSGATKGMTPIKLALAGMAIHLFFSSMTEGIIIL-NENSNEQVMFWLVG 195
Cdd:COG0609   82 LAIVLGGGLSALGLPLAaFLGALLAALLVYLLARRGGGLSPLRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVFWLMG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 196 SLSSMKWDEILTILPWIIGALIVTIFIGRQLTIMELGDDIAKGLGQNINKVRIIIGLLVIILTGMSVSVAGPIGFVGLIV 275
Cdd:COG0609  162 SLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVV 241

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446897653 276 PHIVKRYVSKNYLVMIPLTFIIGADLLLLSDVLSRLITYPYESPVGIVTSFVGALYFLFITIKG 339
Cdd:COG0609  242 PHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRR 305
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 39-339 2.19e-93

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 280.42  E-value: 2.19e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  39 MAIGSSKINFSDIIHYVTGHT-DTKATFLLHNVRMPRMIAGLFIGGALAVSGLLMQAMTRNPLASPKIFGVSSGASFFIV 117
Cdd:COG0609    2 LSLGAVPISLSDVLRALLGPDgDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 118 FVTIIIPSLEYYALYLG-VIGAFIGGLTVYTLSGATKGMTPIKLALAGMAIHLFFSSMTEGIIIL-NENSNEQVMFWLVG 195
Cdd:COG0609   82 LAIVLGGGLSALGLPLAaFLGALLAALLVYLLARRGGGLSPLRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVFWLMG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 196 SLSSMKWDEILTILPWIIGALIVTIFIGRQLTIMELGDDIAKGLGQNINKVRIIIGLLVIILTGMSVSVAGPIGFVGLIV 275
Cdd:COG0609  162 SLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVV 241

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446897653 276 PHIVKRYVSKNYLVMIPLTFIIGADLLLLSDVLSRLITYPYESPVGIVTSFVGALYFLFITIKG 339
Cdd:COG0609  242 PHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRR 305
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 31-338 3.37e-88

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 267.47  E-value: 3.37e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653   31 LFICIYLNMAIGSSKINFSDIIHYVTGHTDTKATFLLHNVRMPRMIAGLFIGGALAVSGLLMQAMTRNPLASPKIFGVSS 110
Cdd:pfam01032   2 LLLLILLSLFIGAVKISPSDVFSALLGGDDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  111 GASFFIVFVTIIIPSLEYYAL-YLGVIGAFIGGLTVYTLSGATKGMTPIKLALAGMAIHLFFSSMTEGIIIL-NENSNEQ 188
Cdd:pfam01032  82 GAALGAVLAILLGGSLSLFALpLAAFIGALLAALLVYFLSRGRGGASPLRLILAGIAVSALLSALTSLLLLLlNPEALQS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  189 VMFWLVGSLSSMKWDEILTILPWIIGALIVTIFIGRQLTIMELGDDIAKGLGQNINKVRIIIGLLVIILTGMSVSVAGPI 268
Cdd:pfam01032 162 ILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPI 241

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  269 GFVGLIVPHIVKRYVSKNYLVMIPLTFIIGADLLLLSDVLSRLITYPYESPVGIVTSFVGALYFLFITIK 338
Cdd:pfam01032 242 GFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
66-329 8.63e-65

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 216.63  E-value: 8.63e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  66 LLHNVRMPRMIAGLFIGGALAVSGLLMQAMTRNPLASPKIFGVSSGASFFIVFVTIIIPSL-EYYALYLGVIGAFIGGLT 144
Cdd:PRK10577  57 LLHYSRLPRLAIALLVGAALGLAGALLQQVLRNPLASPTTLGVAAGAQLALVLATLFAPALlALASQLAAFAGGLLAAAL 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 145 VYTLSGAtKGMTPIKLALAGMAIHLFFSSMTEGIIILNENSNEQVMFWLVGSLSSMKWDEILTILPWIIGALIVTIFIGR 224
Cdd:PRK10577 137 VFALAGG-KRLSPLRLVLAGMVVSLYLGALTTLLLLFNEQYLQGLFLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLAR 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 225 QLTIMELGDDIAKGLGQNINKVRIIIGLLVIILTGMSVSVAGPIGFVGLIVPHIVKRYVSKNYLVMIPLTFIIGADLLLL 304
Cdd:PRK10577 216 PLTLLGLGDDVARSLGLAVSLTRLAALALAVLLSAAVVSAVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLL 295

                        250       260
                 ....*....|....*....|....*..
gi 446897653 305 SDVLSRLITYPYES--PVGIVTSFVGA 329
Cdd:PRK10577 296 TDQLVRLLAGVGGEllPTGAVTALIGA 322
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 75-335 2.79e-52

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 173.51  E-value: 2.79e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  75 MIAGLFIGGALAVSGLLMQAMTRNPLASPKIFGVSSGASFFIVFVTIIIPSLEYYALYLGVIGAFIGGLTVYTLSGATKG 154
Cdd:cd06550    1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 155 MTPIKLALAGMAIHLFFSSMTEGIIILNENSNEQVMFWLVGSLSSMKWDEILTILPWIIGALIVTIFIGRQLTIMELGDD 234
Cdd:cd06550   81 LSPSKLILIGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDED 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 235 IAKGLGQNINKVRIIIGLLVIILTGMSVSVAGPIGFVGLIVPHIVKRYVSKNYLVMIPLTFIIGADLLLLSDVLSRLITy 314
Cdd:cd06550  161 LAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTLL- 239

                        250       260
                 ....*....|....*....|.
gi 446897653 315 PYESPVGIVTSFVGALYFLFI 335
Cdd:cd06550  240 PSELPVGPVTALLGAPYFLYL 260
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 39-339 2.19e-93

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 280.42  E-value: 2.19e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  39 MAIGSSKINFSDIIHYVTGHT-DTKATFLLHNVRMPRMIAGLFIGGALAVSGLLMQAMTRNPLASPKIFGVSSGASFFIV 117
Cdd:COG0609    2 LSLGAVPISLSDVLRALLGPDgDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 118 FVTIIIPSLEYYALYLG-VIGAFIGGLTVYTLSGATKGMTPIKLALAGMAIHLFFSSMTEGIIIL-NENSNEQVMFWLVG 195
Cdd:COG0609   82 LAIVLGGGLSALGLPLAaFLGALLAALLVYLLARRGGGLSPLRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVFWLMG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 196 SLSSMKWDEILTILPWIIGALIVTIFIGRQLTIMELGDDIAKGLGQNINKVRIIIGLLVIILTGMSVSVAGPIGFVGLIV 275
Cdd:COG0609  162 SLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVV 241

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446897653 276 PHIVKRYVSKNYLVMIPLTFIIGADLLLLSDVLSRLITYPYESPVGIVTSFVGALYFLFITIKG 339
Cdd:COG0609  242 PHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRR 305
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 31-338 3.37e-88

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 267.47  E-value: 3.37e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653   31 LFICIYLNMAIGSSKINFSDIIHYVTGHTDTKATFLLHNVRMPRMIAGLFIGGALAVSGLLMQAMTRNPLASPKIFGVSS 110
Cdd:pfam01032   2 LLLLILLSLFIGAVKISPSDVFSALLGGDDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  111 GASFFIVFVTIIIPSLEYYAL-YLGVIGAFIGGLTVYTLSGATKGMTPIKLALAGMAIHLFFSSMTEGIIIL-NENSNEQ 188
Cdd:pfam01032  82 GAALGAVLAILLGGSLSLFALpLAAFIGALLAALLVYFLSRGRGGASPLRLILAGIAVSALLSALTSLLLLLlNPEALQS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  189 VMFWLVGSLSSMKWDEILTILPWIIGALIVTIFIGRQLTIMELGDDIAKGLGQNINKVRIIIGLLVIILTGMSVSVAGPI 268
Cdd:pfam01032 162 ILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPI 241

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  269 GFVGLIVPHIVKRYVSKNYLVMIPLTFIIGADLLLLSDVLSRLITYPYESPVGIVTSFVGALYFLFITIK 338
Cdd:pfam01032 242 GFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 16-342 1.61e-65

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 210.36  E-value: 1.61e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  16 RKRRTTLTYIVSLCFLFICIYLNMAIGSSKINFSDIIHYVTGHTDTKATFLLHNVRMPRMIAGLFIGGALAVSGLLMQAM 95
Cdd:COG4779   18 LRRRALLVTLVLLLLLLALAVLALTLGDYPLSPGDVLRALLGEGDPGASFVVLELRLPRALAALLVGAALGLSGAIFQSL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  96 TRNPLASPKIFGVSSGASFFIVFVTIIIPSLEYYALYLGVIGAFIGGLTVYTLSGaTKGMTPIKLALAGMAIHLFFSSMT 175
Cdd:COG4779   98 TRNPLASPDIIGITAGASAGAVAAIVVLGGSGLAVALGALAGGLATALLVYLLAW-RGGVSGYRLILVGIGVSAMLTAVN 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 176 EGIII-LNENSNEQVMFWLVGSLSSMKWDEILTILPWIIGALIVTIFIGRQLTIMELGDDIAKGLGQNINKVRIIIGLLV 254
Cdd:COG4779  177 SYLLTrADLEDAQSAAVWLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRVERTRLLLLLVA 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 255 IILTGMSVSVAGPIGFVGLIVPHIVKRYVSKNYLVMIPlTFIIGADLLLLSDVLSRLITYPYESPVGIVTSFVGALYFLF 334
Cdd:COG4779  257 VALAAVATAAAGPIAFVALAAPQIARRLTRSPGPPLLP-SALVGALLLLAADLVAQHLLAPVQLPVGVVTGALGGPYLLW 335


                 ....*...
gi 446897653 335 ITIKGVKR 342
Cdd:COG4779  336 LLIRENRR 343
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
66-329 8.63e-65

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 216.63  E-value: 8.63e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  66 LLHNVRMPRMIAGLFIGGALAVSGLLMQAMTRNPLASPKIFGVSSGASFFIVFVTIIIPSL-EYYALYLGVIGAFIGGLT 144
Cdd:PRK10577  57 LLHYSRLPRLAIALLVGAALGLAGALLQQVLRNPLASPTTLGVAAGAQLALVLATLFAPALlALASQLAAFAGGLLAAAL 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 145 VYTLSGAtKGMTPIKLALAGMAIHLFFSSMTEGIIILNENSNEQVMFWLVGSLSSMKWDEILTILPWIIGALIVTIFIGR 224
Cdd:PRK10577 137 VFALAGG-KRLSPLRLVLAGMVVSLYLGALTTLLLLFNEQYLQGLFLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLAR 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 225 QLTIMELGDDIAKGLGQNINKVRIIIGLLVIILTGMSVSVAGPIGFVGLIVPHIVKRYVSKNYLVMIPLTFIIGADLLLL 304
Cdd:PRK10577 216 PLTLLGLGDDVARSLGLAVSLTRLAALALAVLLSAAVVSAVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLL 295

                        250       260
                 ....*....|....*....|....*..
gi 446897653 305 SDVLSRLITYPYES--PVGIVTSFVGA 329
Cdd:PRK10577 296 TDQLVRLLAGVGGEllPTGAVTALIGA 322
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
55-335 1.19e-56

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 186.82  E-value: 1.19e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  55 VTGHTDTKATFLLHNVRMPRMIAGLFIGGALAVSGLLMQAMTRNPLASPKIFGVSSGASFFIVFVTIIIPS-LEYYALYL 133
Cdd:PRK11228  35 LPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALTSALSPTpFAGYSLAF 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 134 -GVIGAFIGGLTVYTLSGATKGMTPI-KLALAGMAIHLFFSSMTEGIIILNENSNEQVMFWLVGSLSSMKWDEILTILPW 211
Cdd:PRK11228 115 iAACGGGLSWLLVMTAGGGWRHTHDRnRLILAGIALSALCMALTRITLLLAEDHAYGIFYWLAGGVSHARWQEVWQLLPF 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 212 IIGALIVTIFIGRQLTIMELGDDIAKGLGQNINKVRIIIGLLVIILTGMSVSVAGPIGFVGLIVPHIVKRYVSKNYLVMI 291
Cdd:PRK11228 195 VVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVPHLARFWIGYDQRNVL 274

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 446897653 292 PLTFIIGADLLLLSDVLSRLITYPYESPVGIVTSFVGALYFLFI 335
Cdd:PRK11228 275 PMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWL 318
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
16-342 9.32e-56

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 192.36  E-value: 9.32e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  16 RKRRTTLTYIVSLCFLFICIYLNMAIGSSkinfSDIIHYVTGHTDTkatfLLHNVRMPRMIAGLFIGGALAVSGLLMQAM 95
Cdd:PRK10577 350 RRRRVLAWLLALGLLLLLALVVALSFGRD----AHGWNWLSGQLLD----ALLPLRLPRLLAALLAGAMLAVAGTLLQRL 421

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  96 TRNPLASPKIFGVSSGASFFIVFVTIIIPSLEYYALYL-GVIGAFIGGLTVYTLSGATkGMTPIKLALAGMAIHLFFSSM 174
Cdd:PRK10577 422 TRNPLASPEVLGISSGAGLGVVLALFLVPGAGFGWLLAaALLGALAALALILLLARRG-GFAPERLLLTGIALSALFTAL 500

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 175 TeGIIILNENSN-EQVMFWLVGSLSSMKWDEILTILPWIIGALIVTIFIGRQLTIMELGDDIAKGLGQNINKVRIIIGLL 253
Cdd:PRK10577 501 I-QLLLASGDPRaAQLLTWLSGSTYGVTWAQALPLLIVAVLLLALALLLRRWLDLLPLGDDTARALGLPVTRARLALLLL 579

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 254 VIILTGMSVSVAGPIGFVGLIVPHIVKRYVSKNYLVMIPLTFIIGADLLLLSDVLSRLITYPYESPVGIVTSFVGALYFL 333
Cdd:PRK10577 580 AALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLADWLGRTLLFPYQIPAGLLAALIGAPYFL 659


                 ....*....
gi 446897653 334 FITIKGVKR 342
Cdd:PRK10577 660 WLLRRSRRR 668
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
19-338 3.15e-55

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 182.94  E-value: 3.15e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  19 RTTLTYIVSLCFLFICIYLNMAIGSSKINFSDIIHyvTGHTDTKATFLLHNVRMPRMIAGLFIGGALAVSGLLMQAMTRN 98
Cdd:PRK09777   1 MKIALVIFITLALAGCALLSLRMGVIPLPWRALLT--DWQAGDEHYYVLMEYRLPRLLLALFVGAALAVSGVLVQGIVRN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  99 PLASPKIFGVSSGASFFIVFVTIIIPSLEYYALYLGvigAFIGGLTVYTLSGATKGM-TPIKLALAGMAIHLFFSSMTEG 177
Cdd:PRK09777  79 PLASPDILGVNHAASLASVGALLLFPSLPVMWLPLL---AFIGGMAGLILLKMLAGThQPMKLALTGVALSALWASLTDY 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 178 IIILNENSNEQVMFWLVGSLSSMKWDEILTILPWIIGALIVTIFIGRQLTIMELGDDIAKGLGQNINKVRIIIGLLVIIL 257
Cdd:PRK09777 156 LMLSRPQDINNALLWLTGSLWGRDWSFVKVALPWLILLLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALLLAVAL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 258 TGMSVSVAGPIGFVGLIVPHIVKRYVSKNYLVMIPLTFIIGADLLLLSDVLSRLITYPYESPVGIVTSFVGALYFLFITI 337
Cdd:PRK09777 236 TATGVAACGPISFIGLVVPHLMRSLVGGRHRRLLPVSALTGALLLLLADLLARIIHPPLELPAGVLTAIIGAPWFFWLLV 315


                 .
gi 446897653 338 K 338
Cdd:PRK09777 316 R 316
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 75-335 2.79e-52

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 173.51  E-value: 2.79e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  75 MIAGLFIGGALAVSGLLMQAMTRNPLASPKIFGVSSGASFFIVFVTIIIPSLEYYALYLGVIGAFIGGLTVYTLSGATKG 154
Cdd:cd06550    1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 155 MTPIKLALAGMAIHLFFSSMTEGIIILNENSNEQVMFWLVGSLSSMKWDEILTILPWIIGALIVTIFIGRQLTIMELGDD 234
Cdd:cd06550   81 LSPSKLILIGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDED 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 235 IAKGLGQNINKVRIIIGLLVIILTGMSVSVAGPIGFVGLIVPHIVKRYVSKNYLVMIPLTFIIGADLLLLSDVLSRLITy 314
Cdd:cd06550  161 LAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTLL- 239

                        250       260
                 ....*....|....*....|.
gi 446897653 315 PYESPVGIVTSFVGALYFLFI 335
Cdd:cd06550  240 PSELPVGPVTALLGAPYFLYL 260
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
27-335 1.39e-45

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 158.33  E-value: 1.39e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  27 SLCFLFICIYLNMAIGSSKINFSDIIHYVTGHTDTKATFLLHNVRMPRMIAGLFIGGALAVSGLLMQAMTRNPLASPKIF 106
Cdd:PRK10441  16 LLLLLIIATALSLLIGAKSLPASVVLEALSGTCQSADCTIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 107 GVSSGASFFIVF-VTIIIPSLEYYALYLGVIGAFIGGLTVYtLSGATKG--MTPIKLALAGMAIHLFFSSMTEGIIILNE 183
Cdd:PRK10441  96 GVNAGASFAIVLgAALFGYSSAQEQLAMAFAGALVASLIVA-FTGSQGGgqLSPVRLTLAGVALAAVLEGLTSGIALLNP 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 184 NSNEQVMFWLVGSLSSMKWDEILTILPWIIGALIVTIFIGRQLTIMELGDDIAKGLGQNINKVRIIIGLLVIILTGMSVS 263
Cdd:PRK10441 175 DVYDQLRFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATA 254

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446897653 264 VAGPIGFVGLIVPHIVKRYVSKNYLVMIPLTFIIGADLLLLSDVLSRLITyPYESPVGIVTSFVGALYFLFI 335
Cdd:PRK10441 255 VVGPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGRLLV-PGELRVSVVSAFIGAPVLIFL 325
btuC PRK09535
cobalamin ABC transporter permease BtuC;
70-335 7.48e-43

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 151.83  E-value: 7.48e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  70 VRMPRMIAGLFIGGALAVSGLLMQAMTRNPLASPKIFGVSSGASF----FIVFVTIIIPSLEYYALylgvIGAFIGGLTV 145
Cdd:PRK09535  94 IRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVgavaAIVLPLAVPFGLQAAAF----AGALVAAFGV 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 146 YTLsgATK-GMTPIK-LALAGMAIHLFFSSMTEGIIILNENSNEQVMFWLVGSLSSMKWDEILTILPWIIGALIVTIFIG 223
Cdd:PRK09535 170 YAI--ATEnGRTPVAtLLLAGVAVQTFLGAVISYLLLHSGESLRRAVYWLMGHLHGSTWSDVEVALPVVVVGFVVLLAYA 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 224 RQLTIMELGDDIAKGLGQNINKVRIIIGLLVIILTGMSVSVAGPIGFVGLIVPHIVKRYVSKNYLVMIPLTFIIGADLLL 303
Cdd:PRK09535 248 RDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTSALAGASFLV 327

                        250       260       270
                 ....*....|....*....|....*....|..
gi 446897653 304 LSDVLSRliTYPYESPVGIVTSFVGALYFLFI 335
Cdd:PRK09535 328 ATDTVAR--SGPAEVPVGIVTAALGAPFFLYL 357
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 10-341 1.63e-41

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 147.31  E-value: 1.63e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  10 SAIDHKRKRRTTLTYIVSLCFLFICIYLNMAIGSSKINFSDIihyvtghTDTKATFLLHNVRMPRMIAGLFIGGALAVSG 89
Cdd:COG4139    1 MQLPQRQRRRDRRWLLLLLLLLLLLFVLSLCAGEVWIPPTQW-------LSEAWQLFVWQLRLPRTLAAVLVGASLAVSG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  90 LLMQAMTRNPLASPKIFGVSSGASFFIVFVTIIIPSLeyYALYLGVIGAFIGGLTVYT--LSGATKGMTPIKLALAGMAI 167
Cdd:COG4139   74 AVMQALFENPLAEPGLLGISNGAGVGLVLVVLLGGGL--LPPWLLSLAAIAGALLVTLllLAFARRRLSNARLLLIGVAL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 168 HLFFSS-MTEGIIILNENSNEQVMFWLVGSLSSMKWDEiLTILPWIIGALIVTIFIGRQLTIMELGDDIAKGLGQNINKV 246
Cdd:COG4139  152 GIICSAiMTWAVYFSSSLDLRQLMYWMMGSFGGVDWRQ-LWLLLALLPVLLWLCLQGKPLNLLLLGENQARQLGLSVHRW 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 247 RIIIGLLVIILTGMSVSVAGPIGFVGLIVPHIVKRYVSKNYLVMIPLTFIIGADLLLLSDVLSRLITYPYESPVGIVTSF 326
Cdd:COG4139  231 RNLLVLATGLLVGVSVALAGPIGFVGLVVPHLLRLLGTTDHRFLLPACALAGAALLLLADIIARLALSSAELPIGVVTAT 310

                        330
                 ....*....|....*
gi 446897653 327 VGALYFLFITIKGVK 341
Cdd:COG4139  311 LGAPVFIWLLLRRRK 325
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 9-338 2.22e-34

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 128.53  E-value: 2.22e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653   9 QSAIDHKRKRRTTLTYIVSLCFLFICIyLNMAIGSSKINFSDIIHyvtghtDTKATFLLHnVRMPRMIAGLFIGGALAVS 88
Cdd:PRK03784   4 LTLARQQQRRNRRWLLGLSVLLLLALL-LSLCAGEQWISPGDWLS------PRGELFVWQ-LRLPRTLAVLLVGAALAVS 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  89 GLLMQAMTRNPLASPKIFGVSSGASFFIVFVTIIIPSLeyYALYLGVIGAFIGGL--TVYTLSGATKG-MTPIKLALAGM 165
Cdd:PRK03784  76 GAVMQALFENPLAEPGLLGVSNGAGVALVAAVLLGQGL--LPPWALSLCAIAGALliTLILLRFARRHrLSTSRLLLAGV 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 166 AIHLFFSS-MTEGIIILNENSNEQVMFWLVGSLSSMKWDEILtilpWIIGALIVTIFIGRQ---LTIMELGDDIAKGLGQ 241
Cdd:PRK03784 154 ALGIICSAlMTWAVYFSTSLDLRQLMYWMMGGFGGVDWRQSW----LMLALLPVLIWLCCQgrpLNMLALGEISARQLGL 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 242 NINKVRIIIGLLVIILTGMSVSVAGPIGFVGLIVPHIVKRYVSKNYLVMIPLTFIIGADLLLLSDVLSRLITYPYESPVG 321
Cdd:PRK03784 230 PLWFWRNLLVLATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGASLLLLADIVARLALASAELPIG 309

                        330
                 ....*....|....*..
gi 446897653 322 IVTSFVGALYFLFITIK 338
Cdd:PRK03784 310 VVTATLGAPVFIWLLLR 326
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
18-338 6.89e-32

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 121.74  E-value: 6.89e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  18 RRTTLTYIVSLCFLFICIYLNMAIGSSKINFSDIIHYVTGHTDTKATFLLHNVRMPRMIAGLFIGGALAVSGLLMQAMTR 97
Cdd:PRK10440   6 RRLLITCLLLLAACVAAGLWGLRSGAVTLETSQVFAALMGDAPRSMTMVVTEWRLPRVLMALLIGAALGVSGAIFQSLMR 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653  98 NPLASPKIFGVSSGAsFFIVFVTIIIPSLEYYALYLGVI-GAFIGGLTVYTLSgATKGMTPIKLALAGMAIHLFFSSMTE 176
Cdd:PRK10440  86 NPLGSPDVMGFNTGA-WSGVLVAMVLFGQDLTAIALAAMaGGIVTSLLVWLLA-WRNGIDTFRLIIIGIGVRAMLVAFNT 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 177 GIIIlnENSNEQVM---FWLVGSLSSMKWDEILTILPWIIGALIVTIFIGRQLTIMELGDDIAKGLGQNINKVRIIIGLL 253
Cdd:PRK10440 164 WLLL--KASLETALtagLWNAGSLNGLTWAKTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERSRLLLMLV 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446897653 254 VIILTGMSVSVAGPIGFVGLIVPHIVKRyVSKNYLVMIPLTFIIGADLLLLSDVLSRLITYPYESPVGIVTSFVGALYFL 333
Cdd:PRK10440 242 AVVLTAAATALAGPISFIALVAPHIARR-LSGTARWGLTQAALCGALLLLAADLCAQQLFMPYQLPVGVVTVSLGGIYLI 320


                 ....*
gi 446897653 334 FITIK 338
Cdd:PRK10440 321 VLLIQ 325
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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