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Conserved domains on  [gi|446883179|ref|WP_000960435|]
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class II fructose-bisphosphate aldolase [Helicobacter pylori]

Protein Classification

beta/alpha barrel domain-containing protein( domain architecture ID 229392)

beta/alpha barrel domain-containing protein belongs to a large superfamily with a wide variety of enzymatic functions

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TIM super family cl21457
TIM-like beta/alpha barrel domains; A large family of domains similar to triose phosphate ...
 1-307 0e+00

TIM-like beta/alpha barrel domains; A large family of domains similar to triose phosphate isomerase (TIM) which, in general, share an eight beta/alpha closed barrel structure.


The actual alignment was detected with superfamily member PRK05835:

Pssm-ID: 473867 [Multi-domain]  Cd Length: 307  Bit Score: 630.47  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   1 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYPHIPVALH 80
Cdd:PRK05835   1 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYPHIPVALH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  81 LDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDAVLVNPKEA 160
Cdd:PRK05835  81 LDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDAVLVNPKEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 161 EQFVKESQVDYLAPAIGTSHGAFKFKGDPKLDFERLQEVKRLTNIPLVLHGASAIPDGVRKSYLDAGGDLKGSKGVPFEF 240
Cdd:PRK05835 161 EQFVKESQVDYLAPAIGTSHGAFKFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDDVRKSYLDAGGDLKGSKGVPFEF 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446883179 241 LQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 307
Cdd:PRK05835 241 LQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 307
 
Name Accession Description Interval E-value
PRK05835 PRK05835
class II fructose-1,6-bisphosphate aldolase;
1-307 0e+00

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180280 [Multi-domain]  Cd Length: 307  Bit Score: 630.47  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   1 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYPHIPVALH 80
Cdd:PRK05835   1 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYPHIPVALH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  81 LDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDAVLVNPKEA 160
Cdd:PRK05835  81 LDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDAVLVNPKEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 161 EQFVKESQVDYLAPAIGTSHGAFKFKGDPKLDFERLQEVKRLTNIPLVLHGASAIPDGVRKSYLDAGGDLKGSKGVPFEF 240
Cdd:PRK05835 161 EQFVKESQVDYLAPAIGTSHGAFKFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDDVRKSYLDAGGDLKGSKGVPFEF 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446883179 241 LQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 307
Cdd:PRK05835 241 LQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 307
fruc_bis_ald_ TIGR01859
fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; ...
 2-307 5.45e-161

fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; This model represents of one of several subtypes of the class II fructose-1,6-bisphosphate aldolase, an enzyme of glycolysis. The subtypes are split into several models to allow separation of a family of tagatose bisphosphate aldolases. This form is found in Gram-positive bacteria, a variety of Gram-negative, and in amitochondriate protists. The class II enzymes share homology with tagatose bisphosphate aldolase but not with class I aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 130918  Cd Length: 282  Bit Score: 449.51  E-value: 5.45e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179    2 LVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMG-IDMAVGMVKIMCERYPHIPVALH 80
Cdd:TIGR01859   1 LVNGKEILQKAKKEGYAVGAFNFNNLEWTQAILEAAEEENSPVIIQVSEGAIKYMGgYKMAVAMVKTLIERMSIVPVALH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   81 LDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNisVDEKDAVLVNPKEA 160
Cdd:TIGR01859  81 LDHGSSYESCIKAIKAGFSSVMIDGSHLPFEENLALTKKVVEIAHAKGVSVEAELGTLGGIEDG--VDEKEAELADPDEA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  161 EQFVKESQVDYLAPAIGTSHGafKFKGDPKLDFERLQEVKRLTNIPLVLHGASaipdgvrksyldaggdlkgskGVPFEF 240
Cdd:TIGR01859 159 EQFVKETGVDYLAAAIGTSHG--KYKGEPGLDFERLKEIKELTNIPLVLHGAS---------------------GIPEEQ 215

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446883179  241 LQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 307
Cdd:TIGR01859 216 IKKAIKLGIAKINIDTDCRIAFTAAIRKVLTEKKDEYDPRKILGPAREAIKETVKEKMRLFGSAGKA 282
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 1-306 1.05e-144

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439961  Cd Length: 283  Bit Score: 408.32  E-value: 1.05e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   1 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYpHIPVALH 80
Cdd:COG0191    1 MLVSLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAGLEYLAAMVRAAAEEA-SVPVALH 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  81 LDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDAVLVNPKEA 160
Cdd:COG0191   80 LDHGASFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVGGEEDGVDVDDAEALYTDPEEA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 161 EQFVKESQVDYLAPAIGTSHGAfkFKGDPKLDFERLQEVKRLTNIPLVLHGASaipdgvrksyldaggdlkgskGVPFEF 240
Cdd:COG0191  160 AEFVEETGVDALAVAIGTVHGV--YKGEPKLDFDRLKEIREAVPVPLVLHGGS---------------------GVPDEE 216

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446883179 241 LQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANK 306
Cdd:COG0191  217 IREAIKLGVAKINIDTDLRLAFTAAVREYLAENPDKYDPRKYLKPAREAMKEVVKEKIRLFGSAGK 282
TBP_aldolase_IIB cd00947
Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase ...
 5-305 1.48e-141

Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238477  Cd Length: 276  Bit Score: 399.98  E-value: 1.48e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   5 GNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYpHIPVALHLDHG 84
Cdd:cd00947    1 TKELLKKAREGGYAVGAFNINNLETLKAILEAAEETRSPVILQISEGAIKYAGLELLVAMVKAAAERA-SVPVALHLDHG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  85 TTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEkdAVLVNPKEAEQFV 164
Cdd:cd00947   80 SSFELIKRAIRAGFSSVMIDGSHLPFEENVAKTKEVVELAHAYGVSVEAELGRIGGEEDGVVGDE--GLLTDPEEAEEFV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 165 KESQVDYLAPAIGTSHGAFKFKGdPKLDFERLQEVKRLTNIPLVLHGASAIPDgvrksyldaggdlkgskgvpfEFLQES 244
Cdd:cd00947  158 EETGVDALAVAIGTSHGAYKGGE-PKLDFDRLKEIAERVNVPLVLHGGSGIPD---------------------EQIRKA 215

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446883179 245 VKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSAN 305
Cdd:cd00947  216 IKLGVCKININTDLRLAFTAALREYLAENPKEFDPRKYLAPAIEAVKEVVKHKMELFGSAG 276
F_bP_aldolase pfam01116
Fructose-bisphosphate aldolase class-II;
3-306 5.26e-129

Fructose-bisphosphate aldolase class-II;


Pssm-ID: 460071  Cd Length: 276  Bit Score: 368.28  E-value: 5.26e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179    3 VKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYM--GIDMAVGMVKIMCERYpHIPVALH 80
Cdd:pfam01116   1 VNLKELLKKAKEGGYAVPAFNVNNLETVQAILEAAEEAKSPVILQVSPGAAAKYagGAEALAALVRAAAEAA-GVPVALH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   81 LDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKdaVLVNPKEA 160
Cdd:pfam01116  80 LDHGASFELIKEAIEAGFTSVMIDGSHLPFEENIAITKEVVEYAHARGVSVEAELGRIGGEEDGVVVDEK--LYTDPEEA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  161 EQFVKESQVDYLAPAIGTSHGAFKFKgdPKLDFERLQEVKRLTNIPLVLHGASaipdgvrksyldaggdlkgskGVPFEF 240
Cdd:pfam01116 158 AEFVEATGVDALAVAIGNVHGVYKPG--PKLDFDRLKEIQEAVPVPLVLHGGS---------------------GVPDED 214

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446883179  241 LQESVKGGINKVNTDTDLRIAFIAEVRKVANEdksqFDLRKFFSPAQLALKNVVKERMKLLGSANK 306
Cdd:pfam01116 215 IRKAIKLGVCKINIDTDLQLAFTAAVREYPPN----KDPRKYLRPAEEAMKEVVKEKIRLFGSAGK 276
 
Name Accession Description Interval E-value
PRK05835 PRK05835
class II fructose-1,6-bisphosphate aldolase;
1-307 0e+00

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180280 [Multi-domain]  Cd Length: 307  Bit Score: 630.47  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   1 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYPHIPVALH 80
Cdd:PRK05835   1 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYPHIPVALH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  81 LDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDAVLVNPKEA 160
Cdd:PRK05835  81 LDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDAVLVNPKEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 161 EQFVKESQVDYLAPAIGTSHGAFKFKGDPKLDFERLQEVKRLTNIPLVLHGASAIPDGVRKSYLDAGGDLKGSKGVPFEF 240
Cdd:PRK05835 161 EQFVKESQVDYLAPAIGTSHGAFKFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDDVRKSYLDAGGDLKGSKGVPFEF 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446883179 241 LQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 307
Cdd:PRK05835 241 LQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 307
fruc_bis_ald_ TIGR01859
fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; ...
 2-307 5.45e-161

fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; This model represents of one of several subtypes of the class II fructose-1,6-bisphosphate aldolase, an enzyme of glycolysis. The subtypes are split into several models to allow separation of a family of tagatose bisphosphate aldolases. This form is found in Gram-positive bacteria, a variety of Gram-negative, and in amitochondriate protists. The class II enzymes share homology with tagatose bisphosphate aldolase but not with class I aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 130918  Cd Length: 282  Bit Score: 449.51  E-value: 5.45e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179    2 LVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMG-IDMAVGMVKIMCERYPHIPVALH 80
Cdd:TIGR01859   1 LVNGKEILQKAKKEGYAVGAFNFNNLEWTQAILEAAEEENSPVIIQVSEGAIKYMGgYKMAVAMVKTLIERMSIVPVALH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   81 LDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNisVDEKDAVLVNPKEA 160
Cdd:TIGR01859  81 LDHGSSYESCIKAIKAGFSSVMIDGSHLPFEENLALTKKVVEIAHAKGVSVEAELGTLGGIEDG--VDEKEAELADPDEA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  161 EQFVKESQVDYLAPAIGTSHGafKFKGDPKLDFERLQEVKRLTNIPLVLHGASaipdgvrksyldaggdlkgskGVPFEF 240
Cdd:TIGR01859 159 EQFVKETGVDYLAAAIGTSHG--KYKGEPGLDFERLKEIKELTNIPLVLHGAS---------------------GIPEEQ 215

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446883179  241 LQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 307
Cdd:TIGR01859 216 IKKAIKLGIAKINIDTDCRIAFTAAIRKVLTEKKDEYDPRKILGPAREAIKETVKEKMRLFGSAGKA 282
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 1-306 1.05e-144

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439961  Cd Length: 283  Bit Score: 408.32  E-value: 1.05e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   1 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYpHIPVALH 80
Cdd:COG0191    1 MLVSLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAGLEYLAAMVRAAAEEA-SVPVALH 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  81 LDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDAVLVNPKEA 160
Cdd:COG0191   80 LDHGASFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVGGEEDGVDVDDAEALYTDPEEA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 161 EQFVKESQVDYLAPAIGTSHGAfkFKGDPKLDFERLQEVKRLTNIPLVLHGASaipdgvrksyldaggdlkgskGVPFEF 240
Cdd:COG0191  160 AEFVEETGVDALAVAIGTVHGV--YKGEPKLDFDRLKEIREAVPVPLVLHGGS---------------------GVPDEE 216

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446883179 241 LQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANK 306
Cdd:COG0191  217 IREAIKLGVAKINIDTDLRLAFTAAVREYLAENPDKYDPRKYLKPAREAMKEVVKEKIRLFGSAGK 282
cbbA TIGR00167
ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model ...
 1-307 2.85e-144

ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model include fructose-bisphosphate and tagatose-bisphosphate aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 272938  Cd Length: 288  Bit Score: 407.47  E-value: 2.85e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179    1 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYM-GIDMAVGMVKIMCERYP-HIPVA 78
Cdd:TIGR00167   2 MLVDVKELLQDAKEEGYAIPAFNINNLETINAVLEAAAEEKSPVIIQFSNGAAKYIaGLGAISAMVKAMSEAYPyGVPVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   79 LHLDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDAVLVNPK 158
Cdd:TIGR00167  82 LHLDHGASEEDCAQAVKAGFSSVMIDGSHEPFEENIELTKKVVERAHKMGVSVEAELGTLGGEEDGVSVADESALYTDPE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  159 EAEQFVKESQVDYLAPAIGTSHGAFKfKGDPKLDFERLQEVKRLTNIPLVLHGASAIPDgvrksyldaggdlkgskgvpf 238
Cdd:TIGR00167 162 EAKEFVKLTGVDSLAAAIGNVHGVYK-GEPKGLDFERLEEIQKYVNLPLVLHGGSGIPD--------------------- 219

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446883179  239 EFLQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 307
Cdd:TIGR00167 220 EEIKKAISLGVVKVNIDTELQIAFAAAVRNYYAENKDYYDPRVWLRPGEKAMKEVVLEKIKLFGSANKA 288
TBP_aldolase_IIB cd00947
Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase ...
 5-305 1.48e-141

Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238477  Cd Length: 276  Bit Score: 399.98  E-value: 1.48e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   5 GNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYpHIPVALHLDHG 84
Cdd:cd00947    1 TKELLKKAREGGYAVGAFNINNLETLKAILEAAEETRSPVILQISEGAIKYAGLELLVAMVKAAAERA-SVPVALHLDHG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  85 TTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEkdAVLVNPKEAEQFV 164
Cdd:cd00947   80 SSFELIKRAIRAGFSSVMIDGSHLPFEENVAKTKEVVELAHAYGVSVEAELGRIGGEEDGVVGDE--GLLTDPEEAEEFV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 165 KESQVDYLAPAIGTSHGAFKFKGdPKLDFERLQEVKRLTNIPLVLHGASAIPDgvrksyldaggdlkgskgvpfEFLQES 244
Cdd:cd00947  158 EETGVDALAVAIGTSHGAYKGGE-PKLDFDRLKEIAERVNVPLVLHGGSGIPD---------------------EQIRKA 215

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446883179 245 VKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSAN 305
Cdd:cd00947  216 IKLGVCKININTDLRLAFTAALREYLAENPKEFDPRKYLAPAIEAVKEVVKHKMELFGSAG 276
F_bP_aldolase pfam01116
Fructose-bisphosphate aldolase class-II;
3-306 5.26e-129

Fructose-bisphosphate aldolase class-II;


Pssm-ID: 460071  Cd Length: 276  Bit Score: 368.28  E-value: 5.26e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179    3 VKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYM--GIDMAVGMVKIMCERYpHIPVALH 80
Cdd:pfam01116   1 VNLKELLKKAKEGGYAVPAFNVNNLETVQAILEAAEEAKSPVILQVSPGAAAKYagGAEALAALVRAAAEAA-GVPVALH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   81 LDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKdaVLVNPKEA 160
Cdd:pfam01116  80 LDHGASFELIKEAIEAGFTSVMIDGSHLPFEENIAITKEVVEYAHARGVSVEAELGRIGGEEDGVVVDEK--LYTDPEEA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  161 EQFVKESQVDYLAPAIGTSHGAFKFKgdPKLDFERLQEVKRLTNIPLVLHGASaipdgvrksyldaggdlkgskGVPFEF 240
Cdd:pfam01116 158 AEFVEATGVDALAVAIGNVHGVYKPG--PKLDFDRLKEIQEAVPVPLVLHGGS---------------------GVPDED 214

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446883179  241 LQESVKGGINKVNTDTDLRIAFIAEVRKVANEdksqFDLRKFFSPAQLALKNVVKERMKLLGSANK 306
Cdd:pfam01116 215 IRKAIKLGVCKINIDTDLQLAFTAAVREYPPN----KDPRKYLRPAEEAMKEVVKEKIRLFGSAGK 276
PRK12857 PRK12857
class II fructose-1,6-bisphosphate aldolase;
1-307 1.08e-128

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 237235  Cd Length: 284  Bit Score: 367.90  E-value: 1.08e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   1 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYPhIPVALH 80
Cdd:PRK12857   2 MLVTVAELLKKAEKGGYAVGAFNCNNMEIVQAIVAAAEAEKSPVIIQASQGAIKYAGIEYISAMVRTAAEKAS-VPVALH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  81 LDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDAVLVNPKEA 160
Cdd:PRK12857  81 LDHGTDFEQVMKCIRNGFTSVMIDGSKLPLEENIALTKKVVEIAHAVGVSVEAELGKIGGTEDDITVDEREAAMTDPEEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 161 EQFVKESQVDYLAPAIGTSHGafKFKGDPKLDFERLQEVKRLTNIPLVLHGASaipdgvrksyldaggdlkgskGVPFEF 240
Cdd:PRK12857 161 RRFVEETGVDALAIAIGTAHG--PYKGEPKLDFDRLAKIKELVNIPIVLHGSS---------------------GVPDEA 217

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446883179 241 LQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 307
Cdd:PRK12857 218 IRKAISLGVRKVNIDTNIREAFVARLREVLEKNPDEIDPRKILGPAREAAKEVIREKIRLFGSAGKA 284
gatY PRK12737
tagatose-bisphosphate aldolase subunit GatY;
1-307 5.39e-108

tagatose-bisphosphate aldolase subunit GatY;


Pssm-ID: 183710  Cd Length: 284  Bit Score: 315.48  E-value: 5.39e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   1 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYpHIPVALH 80
Cdd:PRK12737   2 YIISTKNMLKKAQAEGYAVPAFNIHNLETLQVVVETAAELRSPVILAGTPGTFSYAGTDYIVAIAEVAARKY-NIPLALH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  81 LDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDAVLVNPKEA 160
Cdd:PRK12737  81 LDHHEDLDDIKKKVRAGIRSVMIDGSHLSFEENIAIVKEVVEFCHRYDASVEAELGRLGGQEDDLVVDEKDAMYTNPDAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 161 EQFVKESQVDYLAPAIGTSHGAfkFKGDPKLDFERLQEVKRLTNIPLVLHGASaipdgvrksyldaggdlkgskGVPFEF 240
Cdd:PRK12737 161 AEFVERTGIDSLAVAIGTAHGL--YKGEPKLDFERLAEIREKVSIPLVLHGAS---------------------GVPDED 217

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446883179 241 LQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 307
Cdd:PRK12737 218 VKKAISLGICKVNVATELKIAFSDAVKKYFYENPKANDPRKYMTPGKAAMKEVVREKIKVCGSEGKL 284
gatY PRK09195
tagatose-bisphosphate aldolase; Reviewed
 1-307 8.43e-106

tagatose-bisphosphate aldolase; Reviewed


Pssm-ID: 181690  Cd Length: 284  Bit Score: 309.75  E-value: 8.43e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   1 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYpHIPVALH 80
Cdd:PRK09195   2 YLVSTKQMLNNAQRGGYAVPAFNIHNLETMQVVVETAAELHSPVIIAGTPGTFSYAGTEYLLAIVSAAAKQY-HHPLALH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  81 LDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDAVLVNPKEA 160
Cdd:PRK09195  81 LDHHEKFDDIAQKVRSGVRSVMIDGSHLPFAQNISLVKEVVDFCHRFDVSVEAELGRLGGQEDDLQVDEADALYTDPAQA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 161 EQFVKESQVDYLAPAIGTSHGAfkFKGDPKLDFERLQEVKRLTNIPLVLHGASAIPDgvrksyldaggdlkgskgvpfEF 240
Cdd:PRK09195 161 REFVEATGIDSLAVAIGTAHGM--YKGEPKLDFDRLENIRQWVNIPLVLHGASGLPT---------------------KD 217

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446883179 241 LQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 307
Cdd:PRK09195 218 IQQTIKLGICKVNVATELKIAFSQALKNYLTEHPEANDPRHYLQPAKSAMKDVVSKVIADCGCEGKA 284
PRK09196 PRK09196
fructose-bisphosphate aldolase class II;
2-304 4.75e-100

fructose-bisphosphate aldolase class II;


Pssm-ID: 181691  Cd Length: 347  Bit Score: 297.64  E-value: 4.75e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   2 LVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYPHIPVALHL 81
Cdd:PRK09196   3 LISLRQLLDHAAEHGYGVPAFNVNNLEQVQAIMEAADETDSPVILQASAGARKYAGEPFLRHLILAAVEEYPHIPVVMHQ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  82 DHGTTFESCEKAVKAGFTSVMIDASHHA-------FEENLELTSKVVKMAHNAGVSVEAELGRL-------MGIEDNISV 147
Cdd:PRK09196  83 DHGNSPATCQRAIQLGFTSVMMDGSLKAdgktpasYEYNVDVTRKVVEMAHACGVSVEGELGCLgsletgmGGEEDGHGA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 148 DEK---DAVLVNPKEAEQFVKESQVDYLAPAIGTSHGAFKFKGDPK---LDFERLQEV-KRLTNIPLVLHGASAIPDGVR 220
Cdd:PRK09196 163 EGKlshDQLLTDPEEAADFVKKTQVDALAIAIGTSHGAYKFTRKPTgdvLAIDRIKEIhARLPNTHLVMHGSSSVPQELL 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 221 KSYLDAGGDLKGSKGVPFEFLQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKL 300
Cdd:PRK09196 243 DIINEYGGDMPETYGVPVEEIQEGIKHGVRKVNIDTDLRLAMTGAIRRFLAENPSEFDPRKYLKPAMEAMKKICKARYEA 322


                 ....
gi 446883179 301 LGSA 304
Cdd:PRK09196 323 FGTA 326
PRK07084 PRK07084
class II fructose-1,6-bisphosphate aldolase;
2-307 2.74e-95

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180829  Cd Length: 321  Bit Score: 284.31  E-value: 2.74e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   2 LVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKY----MGIDMAVGMVKIMCERYPHIPV 77
Cdd:PRK07084   9 LVNTREMFAKAVKGGYAIPAYNFNNMEQLQAIIQACVETKSPVILQVSKGARKYanatLLRYMAQGAVEYAKELGCPIPI 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  78 ALHLDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEkdAVLVNP 157
Cdd:PRK07084  89 VLHLDHGDSFELCKDCIDSGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVSAEH--HTYTQP 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 158 KEAEQFVKESQVDYLAPAIGTSHGAFKFK---GDPKLDFERLQEV-KRLTNIPLVLHGASAIPDGVRKSYLDAGGDLKGS 233
Cdd:PRK07084 167 EEVEDFVKKTGVDSLAISIGTSHGAYKFKpgqCPPPLRFDILEEIeKRIPGFPIVLHGSSSVPQEYVKTINEYGGKLKDA 246

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446883179 234 KGVPFEFLQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMK-LLGSANKI 307
Cdd:PRK07084 247 IGIPEEQLRKAAKSAVCKINIDSDGRLAMTAAIRKVFDEKPEEFDPRKYLGPARDELKKLYKHKIInVLGSNGKA 321
PRK08610 PRK08610
fructose-bisphosphate aldolase; Reviewed
 2-306 3.07e-94

fructose-bisphosphate aldolase; Reviewed


Pssm-ID: 181501  Cd Length: 286  Bit Score: 280.72  E-value: 3.07e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   2 LVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYM-GIDMAVGMVKIMCERYP-HIPVAL 79
Cdd:PRK08610   3 LVSMKEMLIDAKENGYAVGQYNLNNLEFTQAILEASQEENAPVILGVSEGAARYMsGFYTVVKMVEGLMHDLNiTIPVAI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  80 HLDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDekDAVLVNPKE 159
Cdd:PRK08610  83 HLDHGSSFEKCKEAIDAGFTSVMIDASHSPFEENVATTKKVVEYAHEKGVSVEAELGTVGGQEDDVVAD--GIIYADPKE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 160 AEQFVKESQVDYLAPAIGTSHGAfkFKGDPKLDFERLQEVKRLTNIPLVLHGASaipdgvrksyldaggdlkgskGVPFE 239
Cdd:PRK08610 161 CQELVEKTGIDALAPALGSVHGP--YKGEPKLGFKEMEEIGLSTGLPLVLHGGT---------------------GIPTK 217

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446883179 240 FLQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANK 306
Cdd:PRK08610 218 DIQKAIPFGTAKINVNTENQIASAKAVRDVLNNDKEVYDPRKYLGPAREAIKETVKGKIKEFGTSNR 284
tag_bisphos_ald TIGR01858
class II aldolase, tagatose bisphosphate family; This model describes tagatose-1, ...
 2-307 1.01e-86

class II aldolase, tagatose bisphosphate family; This model describes tagatose-1,6-bisphosphate aldolases, and perhaps other closely related class II aldolases. This tetrameric, Zn2+-dependent enzyme is related to the class II fructose bisphosphate aldolase; fructose 1,6-bisphosphate and tagatose 1,6 bisphosphate differ only in chirality at C4.


Pssm-ID: 130917  Cd Length: 282  Bit Score: 261.33  E-value: 1.01e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179    2 LVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYpHIPVALHL 81
Cdd:TIGR01858   1 IVSTKYMLQDAQAGGYAVPAFNIHNLETIQAVVETAAEMRSPVILAGTPGTFKHAGTEYIVALCSAASTTY-NMPLALHL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   82 DHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDAVLVNPKEAE 161
Cdd:TIGR01858  80 DHHESLDDIRQKVHAGVRSAMIDGSHFPFAQNVKLVKEVVDFCHRQDCSVEAELGRLGGVEDDLSVDEEDALYTDPQEAK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  162 QFVKESQVDYLAPAIGTSHGAfkFKGDPKLDFERLQEVKRLTNIPLVLHGASAIPDgvrksyldaggdlkgskgvpfEFL 241
Cdd:TIGR01858 160 EFVEATGVDSLAVAIGTAHGL--YKKTPKLDFDRLAEIREVVDVPLVLHGASDVPD---------------------EDV 216

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446883179  242 QESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 307
Cdd:TIGR01858 217 RRTIELGICKVNVATELKIAFSGAVKAYFAENPQANDPRYYMRPGKDAMKKVVRNKINVCGSAGRA 282
PRK13399 PRK13399
fructose-bisphosphate aldolase class II;
7-304 1.49e-86

fructose-bisphosphate aldolase class II;


Pssm-ID: 184029  Cd Length: 347  Bit Score: 263.18  E-value: 1.49e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   7 EILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYPHIPVALHLDHGTT 86
Cdd:PRK13399   8 QLLDHAAENGYGVPAFNVNNMEQILAIMEAAEATDSPVILQASRGARKYAGDAMLRHMVLAAAEMYPDIPICLHQDHGNS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  87 FESCEKAVKAGFTSVMIDASHHA-------FEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDE---------- 149
Cdd:PRK13399  88 PATCQSAIRSGFTSVMMDGSLLAdgktpasYDYNVDVTRRVTEMAHAVGVSVEGELGCLGSLETGEAGEEdgvgaegkls 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 150 KDAVLVNPKEAEQFVKESQVDYLAPAIGTSHGAFKFKGDPK---LDFERLQEV-KRLTNIPLVLHGASAIPDGVRKSYLD 225
Cdd:PRK13399 168 HDQMLTDPDQAVDFVQRTGVDALAIAIGTSHGAYKFTRKPDgdiLAIDRIEEIhARLPNTHLVMHGSSSVPQELQEIINA 247

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446883179 226 AGGDLKGSKGVPFEFLQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSA 304
Cdd:PRK13399 248 YGGKMKETYGVPVEEIQRGIKHGVRKVNIDTDIRLAMTGAIRKVLAEHPSEFDPRKALKPAMKAMTALCKQRFEAFGTA 326
PRK07709 PRK07709
fructose-bisphosphate aldolase; Provisional
 2-306 7.80e-85

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 169068  Cd Length: 285  Bit Score: 256.52  E-value: 7.80e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   2 LVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYM-GIDMAVGMVK-IMCERYPHIPVAL 79
Cdd:PRK07709   3 LVSMKEMLNKALEGKYAVGQFNMNNLEWTQAILAAAEEEKSPVILGVSEGAARHMtGFKTVVAMVKaLIEEMNITVPVAI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  80 HLDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDekDAVLVNPKE 159
Cdd:PRK07709  83 HLDHGSSFEKCKEAIDAGFTSVMIDASHHPFEENVETTKKVVEYAHARNVSVEAELGTVGGQEDDVIAE--GVIYADPAE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 160 AEQFVKESQVDYLAPAIGTSHGAfkFKGDPKLDFERLQEVKRLTNIPLVLHGASaipdgvrksyldaggdlkgskGVPFE 239
Cdd:PRK07709 161 CKHLVEATGIDCLAPALGSVHGP--YKGEPNLGFAEMEQVRDFTGVPLVLHGGT---------------------GIPTA 217

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446883179 240 FLQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANK 306
Cdd:PRK07709 218 DIEKAISLGTSKINVNTENQIEFTKAVREVLNKDQEVYDPRKFIGPGRDAIKATVIGKIREFGSNGK 284
FruBisAldo_II_B TIGR01521
fructose-bisphosphate aldolase, class II, Calvin cycle subtype; Members of this family are ...
 2-304 1.19e-84

fructose-bisphosphate aldolase, class II, Calvin cycle subtype; Members of this family are class II examples of the enzyme fructose-bisphosphate aldolase, an enzyme both of glycolysis and (in the opposite direction) of the Calvin cycle of CO2 fixation. A deep split separates the tightly conserved yeast/E. coli/Mycobacterium subtype (all species lacking the Calvin cycle) represented by model TIGR01520 from a broader group of aldolases that includes both tagatose- and fructose-bisphosphate aldolases. This model represents a distinct, elongated, very well conserved subtype within the latter group. Most species with this aldolase subtype have the Calvin cycle.


Pssm-ID: 130584  Cd Length: 347  Bit Score: 258.32  E-value: 1.19e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179    2 LVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYPHIPVALHL 81
Cdd:TIGR01521   1 LISMRQLLDHAAEFGYGVPAFNVNNMEQMRAIMEAADKTDSPVILQASRGARSYAGAPFLRHLILAAIEEYPHIPVVMHQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   82 DHGTTFESCEKAVKAGFTSVMIDASHHA-------FEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDE----- 149
Cdd:TIGR01521  81 DHGNSPATCQRAIQLGFTSVMMDGSLREdaktpadYDYNVRVTAEVVAFAHAVGASVEGELGCLGSLETGMGEAEdghgf 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  150 -----KDAVLVNPKEAEQFVKESQVDYLAPAIGTSHGAFKFKGDPK---LDFERLQEV-KRLTNIPLVLHGASAIPDGVR 220
Cdd:TIGR01521 161 egvldHSQLLTDPEEAADFVKKTKVDALAVAIGTSHGAYKFTRKPTgevLAIQRIEEIhARLPDTHLVMHGSSSVPQEWL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  221 KSYLDAGGDLKGSKGVPFEFLQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKL 300
Cdd:TIGR01521 241 DIINEYGGEIKETYGVPVEEIVEGIKYGVRKVNIDTDLRLASTAAFRRFAAQNPSEFDPRKFLKPTVEAMRDVCIARYEA 320


                  ....
gi 446883179  301 LGSA 304
Cdd:TIGR01521 321 FGTA 324
kbaY PRK12738
tagatose-bisphosphate aldolase subunit KbaY;
8-307 6.88e-77

tagatose-bisphosphate aldolase subunit KbaY;


Pssm-ID: 183711  Cd Length: 286  Bit Score: 236.47  E-value: 6.88e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   8 ILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYpHIPVALHLDHGTTF 87
Cdd:PRK12738   9 LLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTY-NMPLALHLDHHESL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  88 ESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDAVLVNPKEAEQFVKES 167
Cdd:PRK12738  88 DDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEAKRFVELT 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 168 QVDYLAPAIGTSHGAFKFKgdPKLDFERLQEVKRLTNIPLVLHGASAIPDgvrksyldaggdlkgskgvpfEFLQESVKG 247
Cdd:PRK12738 168 GVDSLAVAIGTAHGLYSKT--PKIDFQRLAEIREVVDVPLVLHGASDVPD---------------------EFVRRTIEL 224

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 248 GINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 307
Cdd:PRK12738 225 GVTKVNVATELKIAFAGAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRI 284
PRK08185 PRK08185
hypothetical protein; Provisional
 7-306 6.37e-76

hypothetical protein; Provisional


Pssm-ID: 181275  Cd Length: 283  Bit Score: 233.85  E-value: 6.37e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   7 EILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGiDMAVGMVKIMCERYPhIPVALHLDHGTT 86
Cdd:PRK08185   3 ELLKVAKEHQFAVGAFNVADSCFLRAVVEEAEANNAPAIIAIHPNELDFLG-DNFFAYVRERAKRSP-VPFVIHLDHGAT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  87 FESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDAVLVNPKEAEQFVKE 166
Cdd:PRK08185  81 IEDVMRAIRCGFTSVMIDGSLLPYEENVALTKEVVELAHKVGVSVEGELGTIGNTGTSIEGGVSEIIYTDPEQAEDFVSR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 167 SQVDYLAPAIGTSHGAFKFKGDPKLDFERLQEVKRLTNIPLVLHGASAIPDgvrksyldaggdlkgskgvpfEFLQESVK 246
Cdd:PRK08185 161 TGVDTLAVAIGTAHGIYPKDKKPELQMDLLKEINERVDIPLVLHGGSANPD---------------------AEIAESVQ 219

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 247 GGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANK 306
Cdd:PRK08185 220 LGVGKINISSDMKYAFFKKVREILSDNPSLYEPNQIYPSAIEAAKEVVRHKMDLFNSTGK 279
PRK06806 PRK06806
class II aldolase;
2-306 8.50e-68

class II aldolase;


Pssm-ID: 180705  Cd Length: 281  Bit Score: 213.08  E-value: 8.50e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   2 LVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMaVGMVKIMCERYPHIPVALHL 81
Cdd:PRK06806   3 LVQMKELLKKANQENYGVGAFSVANMEMVMGAIKAAEELNSPIILQIAEVRLNHSPLHL-IGPLMVAAAKQAKVPVAVHF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  82 DHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNiSVDEKdAVLVNPKEAE 161
Cdd:PRK06806  82 DHGMTFEKIKEALEIGFTSVMFDGSHLPLEENIQKTKEIVELAKQYGATVEAEIGRVGGSEDG-SEDIE-MLLTSTTEAK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 162 QFVKESQVDYLAPAIGTSHGAfkFKGDPKLDFERLQEVKRLTNIPLVLHGASAIpdgvrksyldaggdlkgskgVPFEFl 241
Cdd:PRK06806 160 RFAEETDVDALAVAIGNAHGM--YNGDPNLRFDRLQEINDVVHIPLVLHGGSGI--------------------SPEDF- 216

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446883179 242 QESVKGGINKVNTDTDLRIAFIAEVRK--VANEDKSQFDLRKffSPAQLALKNvVKERMKLLGSANK 306
Cdd:PRK06806 217 KKCIQHGIRKINVATATFNSVITAVNNlvLNTPYSDYFTYHQ--DVIKAAYEN-VKKHMQIFGSENK 280
gatY PRK07998
class II aldolase;
2-303 6.88e-67

class II aldolase;


Pssm-ID: 181192  Cd Length: 283  Bit Score: 210.77  E-value: 6.88e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   2 LVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYpHIPVALHL 81
Cdd:PRK07998   3 LVNGRILLDRIQEKHVLAGAFNTTNLETTISILNAIERSGLPNFIQIAPTNAQLSGYDYIYEIVKRHADKM-DVPVSLHL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  82 DHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNiSVDEKDAvLVNPKEAE 161
Cdd:PRK07998  82 DHGKTFEDVKQAVRAGFTSVMIDGAALPFEENIAFTKEAVDFAKSYGVPVEAELGAILGKEDD-HVSEADC-KTEPEKVK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 162 QFVKESQVDYLAPAIGTSHGafkFKGDPKLDFERLQEVKRLTNIPLVLHGASaipdgvrksyldaggdlkgskGVPFEFL 241
Cdd:PRK07998 160 DFVERTGCDMLAVSIGNVHG---LEDIPRIDIPLLKRIAEVSPVPLVIHGGS---------------------GIPPEIL 215

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446883179 242 QESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGS 303
Cdd:PRK07998 216 RSFVNYKVAKVNIASDLRKAFITTVGKAYVNNHNEANLARVMAKAKQAVEEDVYSKIKMMNS 277
PRK06801 PRK06801
ketose 1,6-bisphosphate aldolase;
7-307 3.86e-63

ketose 1,6-bisphosphate aldolase;


Pssm-ID: 180701  Cd Length: 286  Bit Score: 201.13  E-value: 3.86e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   7 EILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYpHIPVALHLDHGTT 86
Cdd:PRK06801   8 NGLAHARKHGYALGAFNVLDSHFLRALFAAAKQERSPFIINIAEVHFKYISLESLVEAVKFEAARH-DIPVVLNLDHGLH 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  87 FESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDAVL-VNPKEAEQFVK 165
Cdd:PRK06801  87 FEAVVRALRLGFSSVMFDGSTLEYEENVRQTREVVKMCHAVGVSVEAELGAVGGDEGGALYGEADSAKfTDPQLARDFVD 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 166 ESQVDYLAPAIGTSHGafKFKGDPKLDFERLQEVKRLTNIPLVLHGASAIPDgvrksyldaggdlkgskgvpfEFLQESV 245
Cdd:PRK06801 167 RTGIDALAVAIGNAHG--KYKGEPKLDFARLAAIHQQTGLPLVLHGGSGISD---------------------ADFRRAI 223

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446883179 246 KGGINKVNTDTDLRIAFIAEVRKVANEDKSQFD-LRKFFSPAQLALKNVVKERMKLLGSANKI 307
Cdd:PRK06801 224 ELGIHKINFYTGMSQAALAAVEQRMTHRHAIYDeFAELLLGIEEAISDTVAQQMRIFGSAGQA 286
PLN02858 PLN02858
fructose-bisphosphate aldolase
 7-306 4.16e-58

fructose-bisphosphate aldolase


Pssm-ID: 215463 [Multi-domain]  Cd Length: 1378  Bit Score: 201.23  E-value: 4.16e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179    7 EILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMvkIMCERYPHIPVALHLDHGTT 86
Cdd:PLN02858 1104 ELLLNAEKGGYAVGAFNVYNLEGIEAVVAAAEAEKSPAILQVHPGALKQGGIPLVSCC--IAAAEQASVPITVHFDHGTS 1181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   87 FESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDAVLVNPKEAEQFVKE 166
Cdd:PLN02858 1182 KHELLEALELGFDSVMVDGSHLSFTENISYTKSISSLAHSKGLMVEAELGRLSGTEDGLTVEEYEAKLTDVDQAKEFIDE 1261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  167 SQVDYLAPAIGTSHGAFKFKGdPKLDFERLQEVKRLT---NIPLVLHGASaipdgvrksyldaggdlkgskGVPFEFLQE 243
Cdd:PLN02858 1262 TGIDALAVCIGNVHGKYPASG-PNLRLDLLKELRALSskkGVLLVLHGAS---------------------GLPESLIKE 1319

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446883179  244 SVKGGINKVNTDTDLRIAFIAEVRKvanedKSQFDLRKFFSPAQLALKNVVKERMKLLGSANK 306
Cdd:PLN02858 1320 CIENGVRKFNVNTEVRTAYMEALSS-----PKKTDLIDVMSAAKEAMKAVVAEKLRLFGSAGK 1377
PRK07315 PRK07315
fructose-bisphosphate aldolase; Provisional
 2-306 3.19e-56

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 180926  Cd Length: 293  Bit Score: 183.55  E-value: 3.19e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   2 LVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMG-IDMAVGMVKIMCERYP-HIPVAL 79
Cdd:PRK07315   3 IVSAEKFVQAARDNGYAVGGFNTNNLEWTQAILRAAEAKKAPVLIQTSMGAAKYMGgYKVCKNLIENLVESMGiTVPVAI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  80 HLDHGTtFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISvdeKDAVLVNPKE 159
Cdd:PRK07315  83 HLDHGH-YEDALECIEVGYTSIMFDGSHLPVEENLKLAKEVVEKAHAKGISVEAEVGTIGGEEDGII---GKGELAPIED 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 160 AEQFVkESQVDYLAPAIGTSHGAF--KFKGdpkLDFERLQEV-KRLTNIPLVLHGASAIPDgvrksyldaggdlkgskgv 236
Cdd:PRK07315 159 AKAMV-ETGIDFLAAGIGNIHGPYpeNWEG---LDLDHLEKLtEAVPGFPIVLHGGSGIPD------------------- 215

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446883179 237 pfEFLQESVKGGINKVNTDTDLRIAFIAEVRKVANE---------DKSQFDLRKFFSPAQLALKNVVKERMKLLGSANK 306
Cdd:PRK07315 216 --DQIQEAIKLGVAKVNVNTECQIAFANATRKFARDyeaneaeydKKKLFDPRKFLAPGVKAIQASVEERIDVFGSANK 292
FTBP_aldolase_II cd00453
Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1, ...
 8-305 8.38e-51

Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to yield fructose-1,6-bisphosphate. TBP-aldolase is tetrameric and produces tagarose-1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. Although structurally similar, the class I aldolases use a different mechanism and are believed to have an independent evolutionary origin.


Pssm-ID: 238255  Cd Length: 340  Bit Score: 171.14  E-value: 8.38e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   8 ILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKY----------------MGIDMAVGMVKIMCER 71
Cdd:cd00453    4 VFQVAKENNFALPAVNCVGTDSINAVLETAAKVKAPVIVQFSNGGASFiagkgvksdvpqgaaiLGAISGAHHVHQMAEH 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  72 YpHIPVALHLDH--GTTFESCEKAVKAG-----------FTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRL 138
Cdd:cd00453   84 Y-GVPVILHTDHcaKKLLPWIDGLLDAGekhfaatgkplFSSHMIDLSEESLQENIEICSKYLERMSKIGMTLEIELGCT 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 139 MGIEDNISVDEKD--AVLVNPKEAEQFVKE----SQVDYLAPAIGTSHGAFKfKGDPKLDFERLQEVKRL---------T 203
Cdd:cd00453  163 GGEEDGVDNSHMDasALYTQPEDVDYAYTElskiSPRFTIAASFGNVHGVYK-KGNVVLTPTILRDSQEYvskkhnlphN 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 204 NIPLVLHGASAIPDgvrksyldaggdlkgskgvpfEFLQESVKGGINKVNTDTDLRIAFIAEVRK--VANE--------- 272
Cdd:cd00453  242 SLNFVFHGGSGSTA---------------------QEIKDSVSYGVVKMNIDTDTQWATWEGVLNyyKANEaylqgqlgn 300

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 446883179 273 -------DKSQFDLRKFFSPAQLALKNVVKERMKLLGSAN 305
Cdd:cd00453  301 pkgedqpNKKYYDPRVWLRAGQTSMIARLEKAFQELNAID 340
PRK09197 PRK09197
fructose-bisphosphate aldolase; Provisional
 6-306 1.01e-21

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 236406  Cd Length: 350  Bit Score: 93.71  E-value: 1.01e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   6 NEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYM---------GIDMAVG------MVKIMCE 70
Cdd:PRK09197  10 QEMFDRAKENGFALPAVNVVGTDSINAVLEGAAEAKSPVIIQFSNGGAAFIagkgvkddgQGAAVLGaiagakHVHEVAE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  71 RYPhIPVALHLDHgttfesC---------------EKAVKAG----FTSVMIDASHHAFEENLELTSKVVKMAHNAGVSV 131
Cdd:PRK09197  90 HYG-VPVILHTDH------CakkllpwidglldagEKHFAAGgkplFSSHMIDLSEEPLEENIEICSKYLERMAKAGMTL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 132 EAELGRLMGIEDNI--SVDEKDAVLVNPKE----AEQFVKESQVDYLAPAIGTSHGAFKfKGDPKLDFERLQE----VKR 201
Cdd:PRK09197 163 EIELGVTGGEEDGVdnSHEDNSKLYTQPEDvlyaYEALGKISGRFTIAASFGNVHGVYK-PGNVKLRPEILKDsqeyVSK 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 202 LTNIP-----LVLHGASaipdgvrksyldaggdlkgskGVPFEFLQESVKGGINKVNTDTDLRIAFIAEVRK--VANED- 273
Cdd:PRK09197 242 KFGLPakpfdFVFHGGS---------------------GSTLEEIREAVSYGVVKMNIDTDTQWAFWRGVLDyyFKNYDy 300

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 446883179 274 ---------------KSQFDLRKFFSPAQLALKNVVKERMKLLGSANK 306
Cdd:PRK09197 301 lqgqvgnpegedkpnKKYYDPRVWLRAAEASMAARLEEAFEDLNSIGV 348
FBP_aldolase_IIA cd00946
Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the ...
 6-306 4.05e-20

Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is homodimeric and used in gluconeogenesis and glycolysis. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238476  Cd Length: 345  Bit Score: 88.96  E-value: 4.05e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179   6 NEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMG------------IDMAVGM---VKIMCE 70
Cdd:cd00946    5 LKLFDYAKENGFAIPAVNCTSSSTINAVLEAARDAKSPIIIQFSNGGAAFYAgkglknekqkasIAGAIAAahhVRSMAE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179  71 RYpHIPVALHLDHGTT---------FESCEKAVKAG----FTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGR 137
Cdd:cd00946   85 HY-GVPVVLHTDHCAKkllpwfdglLEADEEYFKQHgeplFSSHMLDLSEEPLEENIEICKKYLERMAKINMWLEMEIGI 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 138 LMGIEDniSVDEKDAVLvnpkeAEQFVKESQVDY-------------LAPAIGTSHGAFKfKGDPKLDFERLQE------ 198
Cdd:cd00946  164 TGGEED--GVDNSGVDN-----AELYTQPEDVWYvyealskispnfsIAAAFGNVHGVYK-PGNVKLQPEILGEhqdyvr 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446883179 199 --VKRLTNIPL--VLHGASaipdgvrksyldaggdlkgskGVPFEFLQESVKGGINKVNTDTDLRIAFIAEVRK--VANE 272
Cdd:cd00946  236 ekLGLADDKPLyfVFHGGS---------------------GSTKEEIREAISYGVVKMNIDTDTQWAYWEGVRNyyLKNE 294

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 446883179 273 D----------------KSQFDLRKFFSPAQLALKNVVKERMKLLGSANK 306
Cdd:cd00946  295 DylqgqignpegpdkpnKKYYDPRVWLREGEKSMVARVKKAFEDLNSVNK 344
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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