|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
27-437 |
0e+00 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 573.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 27 RIQALLSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAI 106
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 107 VNVGLGFS----SAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGS 182
Cdd:cd17345 81 INILIGFVpsatSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 183 EHWQSAsYIVPACVAVIFALIVLVLGKGSPREEGLPSLEQMMPEEKVIlktKNTAKAPENMSAWQIFCTYVLRNKNAWYI 262
Cdd:cd17345 161 GWWRGA-FIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKGDYPEE---ADGEEEEQELSAWEIFVKYVLKNKLLWYI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 263 SLVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFVCLIG 342
Cdd:cd17345 237 AIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPTGIIFMILVIVALIV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 343 YWKSESLLMVTIFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIFGASLGTSLFGVMVDKLGWYGGFYLL 422
Cdd:cd17345 317 YWLAPNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGSVLATALIGIIVDHFGWNGGFIVL 396
|
410
....*....|....*
gi 446878488 423 MGGIVCCILFCYLSH 437
Cdd:cd17345 397 LASCILAIIFLALVA 411
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
35-419 |
2.48e-159 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 455.68 E-value: 2.48e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 35 FLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFS 114
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 115 SAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGSEHWQsasYIVPA 194
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWV---FIVPG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 195 CVAVIFALIVLVLGKGSPREEGLPSLEQMMPEEkvilKTKNTAKAPENMSAWQIFCTYVLRNKNAWYISLVDVFVYMVRF 274
Cdd:TIGR00881 158 IIAIIVSLICFLLLRDSPQSCGLPPAEEMPNEE----PDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 275 GMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFVCLIGYWK--SESLLMV 352
Cdd:TIGR00881 234 GILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWLnpAANPLMD 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446878488 353 TIFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIFGASLGTSLfGVMVDKLGWYGGF 419
Cdd:TIGR00881 314 LICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPL-GYLADGFGWAGAF 379
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
1-450 |
2.15e-107 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 325.90 E-value: 2.15e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 1 MLTILKTGQSAHKVPPEKVQATYGRYRIQALLSVFLGYLAYYIVRNNFTLSTPYLKEQlDLSATQIGLLSSCMLIAYGIS 80
Cdd:PRK11273 1 MLSIFKPAPHKARLPAAEIDPTYRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 81 KGVMSSLADKASPKVFMACGLVLCAIVNVGLGF----SSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGA 156
Cdd:PRK11273 80 KFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFvpwaTSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 157 FWNISHNVGGGIVAPIVGAAFAILGSehWQSASYiVPACVAVIFALIVLVLGKGSPREEGLPSLEqmmpEEKVILKTKNT 236
Cdd:PRK11273 160 VWNCAHNVGGGLPPLLFLLGMAWFND--WHAALY-MPAFAAILVALFAFAMMRDTPQSCGLPPIE----EYKNDYPDDYN 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 237 AKAPENMSAWQIFCTYVLRNKNAWYISLVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWL 316
Cdd:PRK11273 233 EKHEQELTAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWM 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 317 SDKLFKGRRMPLAMICMALIFVCLIGYW-KSESLLMVTIFAAIV-GCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMS 394
Cdd:PRK11273 313 SDKVFRGNRGATGVFFMTLVTIATIVYWlNPAGNPTVDMACMIViGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFG 392
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 395 YIFGASLGTSLFGVMVDKLGWYGGFYLLMGGIVCCILFCYLS----HRGALELERQRQNA 450
Cdd:PRK11273 393 YLGGSVAASAIVGYTVDFFGWDGGFMVMIGGSILAVILLIVVmigeKRHHEELLQKRNGG 452
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
28-431 |
3.14e-80 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 256.13 E-value: 3.14e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 28 IQALLSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIV 107
Cdd:PRK09556 28 MQSYLVVFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAIC 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 108 NVGLGFS-----SAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIvapivGAAFAILGS 182
Cdd:PRK09556 108 MLGFGASlgsgsVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAG-----AGGVALWGA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 183 EHWQSAS----YIVPACVAVIFALIVLVLGKGSPREEGLPSLEQMMPEEKvilKTKNTAKAPENMSAWQIFCTYVLRNKN 258
Cdd:PRK09556 183 NYFFDGHvigmFIFPSIIALIIGFIGLRYGSDSPEELGWGKAEEIFGEPI---SEEDKETESTDMTKWQIFVEYVLKNPV 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 259 AWYISLVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfKGRRMPLAMICMALIFV 338
Cdd:PRK09556 260 IWLLCFANIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLA-NGRRALVACIALALIIF 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 339 CLIGYWKSESLLMVTIFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIFGASL--------------GTS 404
Cdd:PRK09556 339 TLGVYQHATSEYMYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGVANGIKGTFAYLFGDSFakvglgmiadptknGTP 418
|
410 420
....*....|....*....|....*..
gi 446878488 405 LFGVMVDklGWYGGFYLLMGGIVCCIL 431
Cdd:PRK09556 419 IFGYTLT--GWAGTFAALDIAAIGCIC 443
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
27-433 |
1.13e-79 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 251.42 E-value: 1.13e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 27 RIQALLSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAI 106
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 107 VNVGLGFSSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGsehWQ 186
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYG---WR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 187 SAsYIVPACVAVIFALIVLVLGKGSPReeglpsleqmmpeekvilktkntakapenmsawqifctYVlrnknaWYISLVD 266
Cdd:cd17312 158 AA-FLVPGIVGLVVAIILFFFLRDSPP--------------------------------------YV------WVLSLAY 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 267 VFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFVCLIGYWKS 346
Cdd:cd17312 193 AFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALFWFF 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 347 -ESLLMVTIFAAIVGCLIYVPQ-FLASVQTMEIVPSFAVGSAVGLRGFMSYIfGASLGTSLFGVMVDKLGWYGGFYLLMG 424
Cdd:cd17312 273 pHNKLLSIVLLFLIGFFVGGPInLIGGAAAQDIGRKEAAGTATGFVGLFGYL-GASLAGLPLGYIIDHYGWSTVFYFLIS 351
|
....*....
gi 446878488 425 GIVCCILFC 433
Cdd:cd17312 352 AALLSVLLL 360
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
20-438 |
1.47e-62 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 207.03 E-value: 1.47e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 20 QATYGRYRIQALLSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMAC 99
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 100 GLVLCAIVNVGLGFSSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAI 179
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 180 LGsehWQSAsYIVPACVAVIFALIVLvlgkgspreeglpsleqmmpeekvilktkntakapenmsawqifctyvlrnkna 259
Cdd:COG2271 161 FG---WRAA-FLILGLPGLLLALLRF------------------------------------------------------ 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 260 WYISLVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKgRRMPLAMICMALIFVC 339
Cdd:COG2271 183 WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGR-RRKLVLAIGLLLAALA 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 340 LIGYWKSESLLMVTIFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIfGASLGTSLFGVMVDKLGWYGGF 419
Cdd:COG2271 262 LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFL-GGALGPLLVGYLLDATGYQAAF 340
|
410
....*....|....*....
gi 446878488 420 YLLMGGIVCCILFCYLSHR 438
Cdd:COG2271 341 LLLAALALLAALLALLLLR 359
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
16-419 |
2.72e-62 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 208.41 E-value: 2.72e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 16 PEKVQATYGRYRIQALLSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKV 95
Cdd:PRK11663 10 KHEIDARYRYWRRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARY 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 96 FMACGLVLCAIVNVGLGFSSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGA 175
Cdd:PRK11663 90 FMGIGLIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 176 AFAILGsehWQsASYIVPACVAVIFALIVLVLGKGSPREEGLPSLEQMMPEEKVILKTKNTAkapeNMSAWQIFCTYVLR 255
Cdd:PRK11663 170 IALHYG---WR-YGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVGEWRHDALELAQQQEGA----GLSRKEILTKYVLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 256 NKNAWYISLVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMAL 335
Cdd:PRK11663 242 NPYIWLLSFSYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLFNGNRGPMNLIFAAG 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 336 IFVCLIGYW--KSESLLMVTIFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIfGASLGTSLFGVMVDKL 413
Cdd:PRK11663 322 ILLSVGSLWlmPFASYVMQAACFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYL-GAALSGYPLAKVLEIW 400
|
....*.
gi 446878488 414 GWYGGF 419
Cdd:PRK11663 401 HWTGFF 406
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
27-422 |
1.57e-55 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 188.77 E-value: 1.57e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 27 RIQALLSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAI 106
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 107 VNVGLGFSSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGsehWQ 186
Cdd:cd17488 81 INILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYG---WR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 187 SASYiVPACVAVIFALIVLVLGKGSPReeglpsleqmmpeekvilktkntakapenmsawqifctYVlrnknaWYISLVD 266
Cdd:cd17488 158 AGMY-VPGIIAILMGIVLCWRLRDRPP--------------------------------------YI------WLLAFCY 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 267 VFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFVCLIGYW-- 344
Cdd:cd17488 193 VLVYVVRTAINDWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLFKGNRGPMNLIFALGLLVSVGALWlv 272
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446878488 345 KSESLLMVTIFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYiFGASLGTSLFGVMVDKLGWYGGFYLL 422
Cdd:cd17488 273 PVHSYWLLATCFFTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAY-LGAALAGYPLAKVIESWGWSGFFIVI 349
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
25-435 |
2.67e-38 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 142.71 E-value: 2.67e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 25 RYRIQALLsvFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLC 104
Cdd:cd17319 1 RWRIIPLL--FLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 105 AIVNVGLGFSsafWIFAALVVFNGLFqGMGVGPSFIT----IANWFPRRERGRVGAFWNISHNVGGGIVAPIVGaafAIL 180
Cdd:cd17319 79 SLFTALTGFA---TSLTSLYVLRFLL-GVAEAGFFPGaikaLAEWFPARERGRATGLFNSGAPLGAAIGPPLSG---WLL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 181 GSEHWQSAsYIVPACVAVIFALIVLVLGkgspreeglpsleqmmpeekvilktkntakapenmsawqifctyvlrnKNAW 260
Cdd:cd17319 152 LLFGWRWA-FIIEGLLGLLLAVLWWFYL------------------------------------------------RQVW 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 261 YISLVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVaflffeWAAIP------STLLAGWLSDKLFKGRRMPLAMICMA 334
Cdd:cd17319 183 GLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGL------LAAIPflagaiGMILGGRLSDRLLRGARRLVIIIGLL 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 335 LIFVCLIGYWKSESLLMVTIFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIfGASLGTSLFGVMVDKLG 414
Cdd:cd17319 257 LAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNL-GGFVAPLLIGYLVDATG 335
|
410 420
....*....|....*....|.
gi 446878488 415 WYGGFYLLMGGIVCCILFCYL 435
Cdd:cd17319 336 SYTAAFLFLAAVALLAALLVL 356
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
31-422 |
1.16e-37 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 142.09 E-value: 1.16e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 31 LLSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVG 110
Cdd:cd17343 5 FASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 111 LGFSSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRErgrVGAFWNI---SHNVGGGiVAPIVgAAFAILgSEHWQS 187
Cdd:cd17343 85 FSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQ---FGTWWSVlstSMNLAGS-LGPIL-ATLLAL-SYGWRS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 188 aSYIVPACVAVIFALIVLVLGKGSPREEGLPSLEQMMPEEKvilktknTAKAPENMSAWqifcTYVLRNKNAWYISLVDV 267
Cdd:cd17343 159 -TLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGK-------KKKSPRGESTL----KELLLSPFLWLLSLGYL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 268 FVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGR--------RMPLAMICMALIFVC 339
Cdd:cd17343 227 VVFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHgsssrgnpRMPLALVFMAGLTVS 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 340 L--IGYWKSE--SLLMVTIFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYiFGASLGTSLFGVMVDKLGW 415
Cdd:cd17343 307 LhlFRVHITSdsSELFILLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAAN-VGGVLAGLPFSYIAKHYDW 385
|
....*..
gi 446878488 416 YGGFYLL 422
Cdd:cd17343 386 RTAFLLL 392
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
34-434 |
1.58e-32 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 127.16 E-value: 1.58e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 34 VFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGF 113
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 114 SSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVgGGIVAPIVGAAFAILGSEHWQSASYIVP 193
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSV-GGILGPLLGGILASSLGFGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 194 ACVAVIFALIVLvlgkgspreeglpsleqmMPEEKVILKTKNTAKAPENMSAWQIFCtyVLRNKNAWYISLVDVFVYMVR 273
Cdd:cd06174 160 ALALLAAILLLL------------------VVPDPPESARAKNEEASSKSVLKLLKR--VLKNPGLWLLLLAIFLVNLAY 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 274 FGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFkgRRMPLAMICMALIFVCLIGYWKSESLLMVT 353
Cdd:cd06174 220 YSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLI--GRKPLLLIGLLLMALGLALLLLAPSLLLLL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 354 IFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIFGASLGTSLFGVMVDKLGWYGGFYLLMGGIVCCILFC 433
Cdd:cd06174 298 LLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
.
gi 446878488 434 Y 434
Cdd:cd06174 378 L 378
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
25-435 |
4.60e-32 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 126.15 E-value: 4.60e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 25 RYRIQALLSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLC 104
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 105 AIVNVGLGFSSAFWIFAALvvfnGLFQGMGVGPSFI----TIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAIL 180
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLL----GLLLGIGGGGSFAvgiaLVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 181 GsehWQSAsYIVPACVAVIFALIVLVLGKGSPREEglpsleqmmpeekvilktknTAKAPENMSAWQIfctyVLRNKNAW 260
Cdd:COG2223 157 G---WRNA-FLILGILLLVVAVLAWLFLRDPPAGA--------------------AAAAKASLRDQLE----ALRDPRFW 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 261 YISLVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFVCL 340
Cdd:COG2223 209 LLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 341 IGYWKSESLLMVTIFAAIVGCLIYVPQFLASVqtMEIVPSFAVGSAVGLrGFMSYIFGASLGTSLFGVMVDKLGWY-GGF 419
Cdd:COG2223 289 ALALGSLWLFLVLFLLLGLALGGGNGAVFALV--PDIFPTKNAGAVYGL-VGAAGGLGGFLGPLLFGALLDATGSYtAAF 365
|
410
....*....|....*.
gi 446878488 420 YLLMGGIVCCILFCYL 435
Cdd:COG2223 366 LVFAVLALVALVLTLL 381
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
34-399 |
1.41e-31 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 123.68 E-value: 1.41e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 34 VFLGYLAYYIVRNNFTLSTP-YLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLG 112
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 113 FSSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVgGGIVAPIVGAAFAILGSehWQSAsYIV 192
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGL-GAALGPLLGGLLASLFG--WRAA-FLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 193 PACVAVIFALIVLVLGKGSPREEglpsleqmmpeekvilKTKNTAKAPENMSAWQIFctyvLRNKNAWYISLVdVFVYMV 272
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKR----------------PKPAEEARLSLIVAWKAL----LRDPVLWLLLAL-LLFGFA 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 273 RFGMISWLPIYlLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFVCLIGYWKSESLLMV 352
Cdd:pfam07690 216 FFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWL 294
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 446878488 353 TIFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIFGA 399
Cdd:pfam07690 295 LLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGA 341
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
25-399 |
7.71e-31 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 122.00 E-value: 7.71e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 25 RYRIQALLSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLC 104
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 105 AIVNVGLGFSSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNIShNVGGGIVAPIVGAAFAILGSEH 184
Cdd:COG2814 86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAG-LGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 185 WqsaSYIVPACVAVIFALIVLVLgkgspreeglpsleqmMPEEKVILKTKNTAKAPEnmsawqifctyVLRNKNAWYISL 264
Cdd:COG2814 165 W---VFLVNAVLALLALLLLLRL----------------LPESRPAARARLRGSLRE-----------LLRRPRLLLLLL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 265 VDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfkgRRMPLAMICMALIFVCLIGYW 344
Cdd:COG2814 215 LAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF---GRRRLLLIGLLLLALGLLLLA 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 446878488 345 KSESLLMVTIFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIFGA 399
Cdd:COG2814 292 LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
31-435 |
3.14e-27 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 112.28 E-value: 3.14e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 31 LLSVFLGYLAYYIVRNNFtlstPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVG 110
Cdd:cd17325 2 SLALFLDMLGYGIIIPIL----PLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 111 LGFSSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGsehwQSASY 190
Cdd:cd17325 78 FAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG----YRAPF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 191 IVPACVAVIFALIVLVlgkgspreeglpsleqmMPEEKVILKTKNTAKAPENMSAWQIfctyVLRNKNAWYISLVDVFVY 270
Cdd:cd17325 154 LVCAALALLALVLALL-----------------LLPEPRPPPNKRAVSAARLRSGLRL----LLRDRRLLALFLAIFVLA 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 271 MVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRmPLAMICMALIFVCLIGYWKSESLL 350
Cdd:cd17325 213 FAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI--GRK-PLILIGLLLSAVALLLLPLATSFW 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 351 MVTIFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIfGASLGTSLFGVMVDKLGWYGGFYLLMGGIVCCI 430
Cdd:cd17325 290 LLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSL-GMVLGPLLGGFLYDAFGFATPFLAAAALLLLAA 368
|
....*
gi 446878488 431 LFCYL 435
Cdd:cd17325 369 VLFLL 373
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
35-427 |
2.48e-25 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 106.94 E-value: 2.48e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 35 FLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFS 114
Cdd:cd17475 2 TLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 115 SAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVApivgAAFAILGSEHWQSASYIVPA 194
Cdd:cd17475 82 GSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAA----ALLPPLALHYGWRAAFVVAG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 195 CVAVIFALIVLVLgkgsPREEGLPSLEqmmpeekvilkTKNTAKAPENMSAwqifctyVLRNKNAWYISLVDVFVYMVRF 274
Cdd:cd17475 158 LVSILAAVLFWLF----YREPPAASAA-----------TESASTLLRSLKE-------VLRNRDVWLIAIAGALLVAPQF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 275 GMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMP----LAMICMALIFVCLIGYWKSESLL 350
Cdd:cd17475 216 ALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRPvlviTAAIAAAALLVLSLLSPGTPLWL 295
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446878488 351 MVTIFAAI-VGCLIYVPQFLAsvQTMEIVPSFAVGSAVGLRGFMSYIfGASLGTSLFGVMVDKLGWYGGFYLLMGGIV 427
Cdd:cd17475 296 LVLLLILLgLFAIGWNGLYLT--LVAESAGPEQAGTALGLANTINFI-GIAIGPPLFGLLVDATHSYAPAWLALALLL 370
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
53-442 |
1.33e-22 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 99.18 E-value: 1.33e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 53 PYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWIFAALVVFNGLFQG 132
Cdd:COG2807 42 PEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 133 MGVGPSFITIANWFPRReRGRVGAFWNISHNVGGGIVApivGAAFAILGSEHWQSAsYIVPACVAVIFALIVLVLGKGSP 212
Cdd:COG2807 122 VGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAA---GLTVPLAAALGWRGA-LAVWALLALLALLLWLPLLRRRP 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 213 REeglpsleqmmpeekvilktknTAKAPENMSAWQifctyVLRNKNAWYISLVDVFVYMVRFGMISWLPIYLLTvKHFSK 292
Cdd:COG2807 197 AA---------------------AAAAPAAASLRS-----LWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 293 EQMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRMPLAMICMALIFVCLIGYW--KSESLLMVTIFAAIVGCLIYVpqfLA 370
Cdd:COG2807 250 ATAGLLLSLFQLAGIPGSLLVPLLADRL--GDRRPLLLLLGLLGLAGLLGLLlaPGSLPWLWAVLLGLGQGGLFP---LA 324
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446878488 371 SVQTMEIVPSFA-VGSAVGLRGFMSYIfGASLGTSLFGVMVDKLG-WYGGFYLLMGGIVCCILFCYLSHRGALE 442
Cdd:COG2807 325 LTLIGLRARTPAeAAALSGMAQSVGYL-LAALGPLLVGALHDATGsWTAALLLLAALAVLMLVAGLLAGRPYVE 397
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
25-438 |
1.87e-22 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 98.77 E-value: 1.87e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 25 RYRIQALLSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLC 104
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 105 AIVNVGLGFSSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRV---GAFWNIshnvgGGIVAPIVGAAFAILG 181
Cdd:COG0738 84 ALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLnllHAFFSL-----GALLGPLLGGLLILLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 182 SEHWQSASYIVpacVAVIFALIVLVLgkgspreeglpsleqmmpeekVILKTKNTAKAPENMSAWQIFCTYVLRNKNAWY 261
Cdd:COG0738 159 LSLSWHLPYLI---LAVLLLLLALLF---------------------LRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 262 ISLVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKlFKGRRMPLAMICMALIFVCLI 341
Cdd:COG0738 215 GGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKR-FGPVRLLRLSALLAAVGLLLA 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 342 GYWKSESLLMVTIFAAIVGCLIYVPQFLASvqTMEIVPSFAvGSAVGLRGFMSYIfGASLGTSLFGVMVDKLGWYGGFYL 421
Cdd:COG0738 294 LLAPGPWLALIGLALVGLGLSLMFPTIFSL--ALDGLGKRT-AAAVSAVLIMGIV-GGAIGPPLIGFLADAFGLRAAFLV 369
|
410
....*....|....*..
gi 446878488 422 LMGGIVCCILFCYLSHR 438
Cdd:COG0738 370 PLVCYLLILLLALALKR 386
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
31-421 |
4.71e-20 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 91.91 E-value: 4.71e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 31 LLSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVG 110
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 111 LGFSSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVG---GGIVAPIVGAAFAilgseHWQS 187
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGsglGYVVGGLVAQATG-----GWRW 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 188 AsYIVPACVAVIFALIVLVLGKGSPREeglpsleqmMPEEKVILKTKNTAKAPENMsawqifctYVLRNKNAWYISLVDV 267
Cdd:cd17328 156 A-FRVTGVLGVLLAILLLLFVREPPRG---------AAEGGVMAKSTATSFLADLK--------ALAKNPSFILSTLGFT 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 268 FVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPS----TLLAGWLSDKLFKGRRMPLAMIC-----MALIFV 338
Cdd:cd17328 218 AVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAgvlgVLLGGILADRLRRKTPRADPLVCavgllAAAPFL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 339 CLIGYWKSESLLMVTIFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIFGASLGTSLFGVMVDKLGWYGG 418
Cdd:cd17328 298 FLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQNKD 377
|
...
gi 446878488 419 FYL 421
Cdd:cd17328 378 SPL 380
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
53-435 |
8.24e-19 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 87.60 E-value: 8.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 53 PYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWIFAALVVFNGLFQG 132
Cdd:cd17324 23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 133 MGVGPSFITIANWFPRRERGRVGAFWnISHNVGGGIVAPIVGAAFAILGSehWQSASYIVPACVAVIFALIVLVLGKGSP 212
Cdd:cd17324 103 GFWAIAAAYAADLVPPEKRGRAIGLV-FSGLTLGLVLGRPLGGLLGQLLG--WRAAFLAIAVLALLAALLLWRLLPSLPP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 213 REEGLPSLEQMMPEekvilktkntakapenmsawqifctyVLRNKNAWYISLVDVFVYMVRFGMISWLPIYLLTVKHFSK 292
Cdd:cd17324 180 KKPGSLGLLSSLLL--------------------------LLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 293 EQMSVAFLFFEWAAIPSTLLAGWLSDKlFKGRRMPLAMICMALIFVCLIGYWKSESLLMVTIFaaIVGCLIYVPQFLASV 372
Cdd:cd17324 234 SAIIGLLLLFGVAGVVGSPLAGRLADR-GGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLV--LWGLGFFAAHSALQT 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446878488 373 QTMEIVPSfAVGSAVGLRGFMSYIfGASLGTSLFGVMVDKLGWYGGFYlLMGGIVCCILFCYL 435
Cdd:cd17324 311 RVLRLAPE-ARGLASSLYLAAYNL-GGALGAALGGLVLDHGGWAGVGW-VGAALLLLALLLAL 370
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
31-435 |
6.53e-18 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 84.95 E-value: 6.53e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 31 LLSVFLGYLAYYIVrnnftLST-PYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNV 109
Cdd:cd17489 2 LLANFFFFLSFYLL-----LPVlPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 110 GLGFSSAFWIFAALVVFNGLFQGMgVGPSFITIANWF-PRRERGRVGAFWNISHNVgGGIVAPIVGAAFailgsehWQSA 188
Cdd:cd17489 77 LYLLATSVALLLVLRLIHGIGWGA-FTTAAATLVADIiPPSRRGEGIGYYGLATTL-AMALGPALGLFL-------YQHL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 189 SYIVPACVAVIFALIVLVLGkgspreeglpsleQMMPEEKVILKTKNTAKAPENMsawqifctyVLRNKNAWYISLVDVF 268
Cdd:cd17489 148 GFAVLFIVAAVLALLALLLV-------------FLVKDPPPVAAEEAEAGTRAFR---------RLVEKKVLPPALILFL 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 269 VYMVRFGMISWLPIYlltvkhFSKEQMSVAFLFFEWAAIPSTL---LAGWLSDKlfKGRRMpLAMICMALIFVCLIGYWK 345
Cdd:cd17489 206 ASIAYGAISTFLPLY------AAERGISNAGLFFTVYAIALLLsrpFSGKLSDR--KGPKT-VIIPGLLLLALGLLLLSF 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 346 SESLLMVTIFAAI--VGCLIYVPQFLAsvQTMEIVPSFAVGSAVGLRgFMSYIFGASLGTSLFGVMVDKLGwYGGFYLLM 423
Cdd:cd17489 277 AGSPWMLLLAAVLygLGFGLLFPALQA--LAVDLVPPHRRGAANGTF-FIFFDLGIGLGGLLLGLVAELFG-YRAMFLLA 352
|
410
....*....|..
gi 446878488 424 GGIVCCILFCYL 435
Cdd:cd17489 353 AVVVLLALVLYI 364
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
53-435 |
4.58e-16 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 79.54 E-value: 4.58e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 53 PYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWIFAALVVFNGLFQG 132
Cdd:cd17474 23 PAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 133 MGVGPSFITIANWFPRRERGRVGAFwNISHNVGGGIVAPIVGaafAILGSEHWQSASYIVPACVAVIFALIVLVLGKgsp 212
Cdd:cd17474 103 GLGPLALTLIGDLFEGGERAKAMGL-YEAALGLGIAVGPLLG---GLLAAISWRYPFFLLAALIPVAFLAILFLLPE--- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 213 reeglpsleqmmPEEKVILKTKNTAKAPENmsawqifctyVLRNKNAWYISLVDVFVYMVRFGMISWLPIYLLTVKHFSK 292
Cdd:cd17474 176 ------------PKEKAKSSSATKLRDLKK----------ALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 293 EQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRR-MPLAMICMALIFVcLIGYWksESLLMVTIFAAIVGCLIYVpqFLAS 371
Cdd:cd17474 234 IIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRiLVIGLLLYALSLL-LLGFV--PSLALLLIAIVLFGLGLGL--NLPL 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446878488 372 VQT--MEIVPSFAVGSAVGLRGFMSYIfGASLGTSLFGVMVDKLGWYGGFYLLMGGIVCCILFCYL 435
Cdd:cd17474 309 LTTlvTELAPEEERGTASSLYNFVRFL-GQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
53-414 |
9.24e-16 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 78.37 E-value: 9.24e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 53 PYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWIFAALVVFNGLfqg 132
Cdd:cd17478 20 PLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGI--- 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 133 mGVG---PSFITIANWFPRRERGRVGAFWNISHNVGGGIvAPIVGAAFAilgSEHWQSASYIVPACVAVIFALIVLVLGK 209
Cdd:cd17478 97 -GSAafhPEGARLASQAAGGRRGLAMSIFSVGGNLGFAL-GPLIAAALV---ALFGGLGLLILLIIPGLAVALLLLRLRP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 210 GSPREeglpsleqmmpeekvilkTKNTAKAPENMSAWQIFctyvlrNKNAWYISLVDVFVYMVRFGMISWLPIYlLTVKH 289
Cdd:cd17478 172 LKKPE------------------AKKAAAKSSARSTLKGV------WRALLLLLIIVFLRSWVLSSLTTFLPFY-LVQRG 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 290 FSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRmPLAMICMALIFVCLIGYWKSESLLMVtIFAAIVGCLIYVPQFL 369
Cdd:cd17478 227 YSLVFAGLLLSLFLFAGAIGTLIGGPLSDRF--GRR-RVIIASLLLAAPFLLLFLLTPGIWSY-ILLVLAGFLLFASFPV 302
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 446878488 370 ASVQTMEIVPSFaVGSAVGLrgFMSYIFG-ASLGTSLFGVMVDKLG 414
Cdd:cd17478 303 TVVLAQELLPGN-VGLASGL--MMGLSFGlGGIGAPVLGALADAFG 345
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
31-431 |
1.43e-15 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 78.04 E-value: 1.43e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 31 LLSVFLGYLAYYIVrnnFTLSTPYLKEQLDLSATQIGLLSSCMLIAyGISKGVMS-SLADKASPKVFMACGLVLCAIVNV 109
Cdd:cd17329 5 LIGSFLNRLGFFMV---WPFMAIYLHQQLGLSASIVGLVLALSAVA-GIVASLIGgRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 110 GLGFSSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIvAPIVGAAFAILGsehwQSAS 189
Cdd:cd17329 81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAI-GPLLGGLLLLYS----FRLL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 190 YIVPACVAVIFALIVLVLgkgsPREEGLPSLEQMMPEEKVILKTkntakapenmsawqifctyVLRNKNAWYISLVDVFV 269
Cdd:cd17329 156 FLAAAVLFLLAALVLLFL----LPETRPKRRAAEKTEILRGYKI-------------------VLRDRAFLLFLLASFLI 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 270 YMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFVCLIGYWKSESL 349
Cdd:cd17329 213 SLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 350 LMVTIFAAIvGCLIYVPqfLASVQTMEIVPSFAVGSAVGLRGfMSYIFGASLGTSLFGVMVDKLGWYGGFYLL-MGGIVC 428
Cdd:cd17329 293 ILAMIVLTL-GEMLVFP--AVQTLVAALAPPDKRGSYMGFYA-LAWGLGRAIGPLVGGLLLDLLGPGLPWLILaALGLIA 368
|
...
gi 446878488 429 CIL 431
Cdd:cd17329 369 AAL 371
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
62-432 |
1.10e-14 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 75.39 E-value: 1.10e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 62 SATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWIF-AALVVFNGLFQGMGVGPSFI 140
Cdd:cd17355 36 SRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLyLLWGLLGGGGAGTLAAVAFA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 141 TIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGsehWQSAsYIVPACVAVIFALIVLVLGKGSPREEGLPSl 220
Cdd:cd17355 116 TVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFG---WRTA-LLVLALLALLVLVPVLLLLRRRPADLALRA- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 221 eqmmpeekvilktKNTAKAPENMSAWqifcTYVLRNKNAWYISLVDVFVYMVRFGMISWLPIYLLTvKHFSKEQMSVAFL 300
Cdd:cd17355 191 -------------YDDASPASPGSTL----KEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 301 FFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFVCLIgyWKSESLLMVTIFAAIVGCLIYVPQFLASVQTMEIVPS 380
Cdd:cd17355 253 LIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLL--LLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGA 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 446878488 381 FAVGSAVGLrGFMSYIFGASLGTSLFGVMVDKLGWYGG-FYLLMG-GIVCCILF 432
Cdd:cd17355 331 RSYGTLFGL-VFAPHQLGSALGPWLGGLLYDRTGSYTAaWALAVAlGLIAALLV 383
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
31-431 |
1.30e-14 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 74.95 E-value: 1.30e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 31 LLSVFLGYLAYYIVRNNFTLSTPYLKE--QLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVN 108
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 109 VGLGFSSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGSEH-WQS 187
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWgWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 188 ASYIvpacvAVIFALIVLVLgkgspreeglpsleqmmpeekvilktkntakapenmsawqifctyvlrNKNAWYISLVDV 267
Cdd:cd17316 161 LFLI-----GALPALLALLL------------------------------------------------RRRTLLLILLWF 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 268 FVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKgRRMPLAMICMALIFVCLIGYWKSE 347
Cdd:cd17316 188 FISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGR-KKTLVIGLILSGILALPLFYLLSG 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 348 SLLMVTIFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIFGASLGTSLFGVMVDKLGWYGGFYLLMGGIV 427
Cdd:cd17316 267 SPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAI 346
|
....
gi 446878488 428 CCIL 431
Cdd:cd17316 347 VALI 350
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
53-435 |
1.66e-14 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 74.92 E-value: 1.66e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 53 PYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWIFAALVVFNGLFQG 132
Cdd:cd17320 23 PAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 133 MGVGPSFITIANWFPRRERGRVGAFWNISHNVgGGIVAPIVGAAFAILGseHWQSASYIVPACVAVIFALIVLVLGKGSP 212
Cdd:cd17320 103 AGSVVARAIVRDLYSGAELAKIFSLLMMILAI-APALAPLLGGLLLLFF--GWRAIFVFLALLGLLLLLLVLLFLPETLP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 213 REEGLPSLEQMmpeekvilktkntakapenmsaWQIFcTYVLRNKNAWYISLVDVFVYMVRFGMISWLPIYLLTVKHFSK 292
Cdd:cd17320 180 EEKRKPLLSSL----------------------LRAY-KRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSP 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 293 EQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFVCLIGYWKSESL----LMVTIFAAIVGCLIYVPQF 368
Cdd:cd17320 237 AQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLslwpLVAPLFLIFFGFGLIFPNA 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446878488 369 LAsvQTMEIVPSFAvGSAVGLRGFMSYIFGAsLGTSLFGVMVDKLGWYGGFYLLMGGIVCCILFCYL 435
Cdd:cd17320 317 TS--LALEPFPHVA-GTASALLGFLQFLIGA-LAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
30-213 |
8.56e-14 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 72.60 E-value: 8.56e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 30 ALLSVFLGYLAYYIVRNNFTL-STPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADK--ASPKVFMACGLVLCAI 106
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTwLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRlgRRRKLVLAIGLLLAAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 107 VNVGLGFSSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGsehWQ 186
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG---YQ 337
|
170 180
....*....|....*....|....*..
gi 446878488 187 SASYIVpACVAVIFALIVLVLGKGSPR 213
Cdd:COG2271 338 AAFLLL-AALALLAALLALLLLRETRK 363
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
30-207 |
1.52e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 71.84 E-value: 1.52e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 30 ALLSVFLGYLAYYIVrnnFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNV 109
Cdd:cd17325 204 LFLAIFVLAFAFGAL---EPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 110 GLGFSSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVgGGIVAPIVGAAFAILGSEHWqsaS 189
Cdd:cd17325 281 LLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSL-GMVLGPLLGGFLYDAFGFAT---P 356
|
170
....*....|....*...
gi 446878488 190 YIVPACVAVIFALIVLVL 207
Cdd:cd17325 357 FLAAAALLLLAAVLFLLL 374
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
30-432 |
4.38e-13 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 70.36 E-value: 4.38e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 30 ALLSVFLGYLAYYIvrnnFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNV 109
Cdd:cd17341 4 SWLSFFLGFMVWFL----FAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 110 GLGFS-SAFWIFAALvvfnGLFQGMGvGPSFIT----IANWFPRRERGRVGAFWNISHNVGGGI---VAPIVGAAFAILG 181
Cdd:cd17341 80 ALALAvSSYWGLLVL----GFLLGFA-GANFASgqpwASFWFPKEKIGGAAGGIAGAGNMGVAVsqlLAPLIAGAIVFDG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 182 SEHWQSASYIVPACVAVIFALIVLVLGKGSPreeglpsleqmmpeekvilktKNTAKAPENMSAWQifctYVLRNKNAWY 261
Cdd:cd17341 155 GFVGWRNAFFVPGILLAIAAVLVLLFGDDLP---------------------TGKASALEFLKVQL----AVLKNYRTWI 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 262 ISLVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKlFKGRRMPLAMICMALIFVCLI 341
Cdd:cd17341 210 LSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDR-FGGRRRLWWLFIVMTIGAALL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 342 GYWKSESLLMVTIFAAIVGCLIYVPQFlASVQTMEIVPSF---AVGSAVGLRGFMSYIFGASLGTSLFGVMVDKLGWYGG 418
Cdd:cd17341 289 SLSLPTSGTNLVLFLALFVALGLGAGA-GNGSVFRMVPFIfrrELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGA 367
|
410
....*....|....
gi 446878488 419 FYLLMGGIVCCILF 432
Cdd:cd17341 368 FSLFGVLAVACTLL 381
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
57-432 |
1.20e-12 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 69.12 E-value: 1.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 57 EQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWIFAALVvfngLFQGMGVG 136
Cdd:cd17477 24 EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLR----FVMGIGLA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 137 PSFITIANWF----PRRERGRVGAFWNIShNVGGGIVAPIVGAAFAILGsehwqsASYIVPACVAVIFALIVLVLGKGSP 212
Cdd:cd17477 100 GLFVVSESWLnalaTNENRGRVLGLYSTV-LGLGFALGPLLLALVGTAG------ALPFLIAAVLLLLALVPLLLTRRAA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 213 REeglpsleqmmpeekvilktkntAKAPENMSAWQIFctyvlrnKNAWyISLVDVFVY-MVRFGMISWLPIYLLTVkHFS 291
Cdd:cd17477 173 PE----------------------IEEAESISLRRLL-------RIAP-LALLGAFVAgFLEGAFYSLLPLYGLRL-GLS 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 292 KEQMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRMPLAMICMALIFVCLIGYWKSESLLMVTIFAAIVGCLIYVPQFLAS 371
Cdd:cd17477 222 VAQAALLLAAFVLGGLLLQWPLGWLADRF--DRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLAL 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446878488 372 VQTMEIVPSFAVGSAVGLRGfMSYIFGASLGTSLFGVMVDKLGWYGGFYLLMGGIVCCILF 432
Cdd:cd17477 300 ALAGDRLPGDELVAANAALL-LLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLF 359
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
31-410 |
1.70e-12 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 68.74 E-value: 1.70e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 31 LLSVFLGYLAYYIVrnnfTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVG 110
Cdd:cd17321 2 LLAVFLAALDVTIV----NVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 111 LGFSSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNIShNVGGGIVAPIVGAafAILGSEHWQSASY 190
Cdd:cd17321 78 CALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAV-VGIGAALGPLLGG--LLLELFGWRWIFL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 191 IvpacvAVIFALIVLVLGkgspreeglpsleqmmpeekvilktkntakapenmsawqifctyvlrnKNAWYISLVDVFVY 270
Cdd:cd17321 155 I-----NVPIGLVALLLA------------------------------------------------RTFSGAVLAAFLLG 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 271 MVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFVCLIGYWKSESLL 350
Cdd:cd17321 182 AALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVW 261
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 351 MVTIFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVGLRGFMSYIfGASLGTSLFGVMV 410
Cdd:cd17321 262 LLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQL-GGALGVALLGALL 320
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
66-433 |
3.04e-12 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 68.11 E-value: 3.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 66 IGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVN--VGLGFSS---AFWIFAALVVFNGLFQGMGvGPSFI 140
Cdd:cd17344 64 LGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTalFGLGYYWnihSLWYFVVVQILAGLFQSTG-WPSVV 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 141 T-IANWFPRRERGRVGAFWNiSHNVGGGIVAPIVGAAFAilgSEHWqSASYIVPacvavifALIVLVLGkgspreeglps 219
Cdd:cd17344 143 AcVGNWFGKGKRGLIMGIWN-SHTSVGNILGSLIAGIFV---SSAW-GLSFIVP-------GIIIAAMG----------- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 220 leqmmpeekvILktkntakapenmsawqIFCTYVLRNKNAWYISLVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAF 299
Cdd:cd17344 200 ----------VL----------------VFLFLVEHPPGVIEFSLCLFFAKLVSYTFLYWLPLYISNTAILSAKKAGDLS 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 300 LFFEWAAIPSTLLAGWLSDKlFKGRrmplAMICMALIFVC-----LIGYWKSESLLMVTIFAAIVGCLIYVPQFL----- 369
Cdd:cd17344 254 TLFDVGGIVGGILAGYISDY-TGGR----ATTCAAMLILAapmlfIYNYFGQVSMTTNIVLLIVCGLLVNGPYALittav 328
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 370 -ASVQTMEIVPsfavGSAVGLRGFMSYI-----FGASLGTSLFGVMVDkLGWYGGFYLLMGGIVCCILFC 433
Cdd:cd17344 329 sADLGTHKSLK----GNARALATVTAIIdgtgsIGAALGPLLAGLISS-RGWNNVFYMLIAADVCAGLLL 393
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
52-414 |
3.15e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 68.00 E-value: 3.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 52 TPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPK-----VFMACGLVLCAIVNVGLGFSSAFWIFAALVVF 126
Cdd:COG2211 34 LYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrrrPWILIGAIPLALSFVLLFTAPDLSPTGKLIYA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 127 NGLFQGMGVGPSFITIANW-------FPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGSEhwQSASYIVPACVAVI 199
Cdd:COG2211 114 LVTYLLLGLAYTLVNIPYSalgaeltPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGD--AALGYRLTALIFAV 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 200 FALIVLVLgkgspreeglpsleqmmpeekVILKTK-NTAKAPENMSAWQIFCTyVLRNKNAWYISLVDVFVYMVRFGMIS 278
Cdd:COG2211 192 LGLLAFLL---------------------TFFGTKeRPVPEEEKVSLKESLKA-LLKNRPFLLLLLAYLLFFLALALVAA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 279 WLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRmPLAMICMALIFVCLIGYW--KSESLLMVTIFA 356
Cdd:COG2211 250 LLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRF--GKK-KAFIIGLLLAALGLLLLFflGPGNLWLLLVLA 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446878488 357 AIVGCLIYVPQFLASVQTMEIVPS-------FAVGSAVGLRGFMSYIfGASLGTSLFGVMVDKLG 414
Cdd:COG2211 327 ALAGIGLGAILVLPWAMLADVVDYdewktgrRREGLYFGIFTFAIKL-GQALAGALAGLLLALFG 390
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
32-362 |
1.34e-11 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 65.79 E-value: 1.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 32 LSVFLGYLAYYIVRnnfTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGL 111
Cdd:TIGR00886 8 FGFFLSFLVWFAFS---PLAVFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 112 GFS-SAFWIFAALVVFNGlFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGSEH------ 184
Cdd:TIGR00886 85 GLAvQSYSVLLLIRLFIG-IAGGSFASCMPWISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIGSLIFGGgqpahl 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 185 -WQSASYIVPACVAVIFALIVLVLGKGSPReeGLPSLEQMMPEEkvilktkntakapenmsAWQIFctyvlRNKNAWYIS 263
Cdd:TIGR00886 164 aWGWAFVIVPAGILLLPALLIFFVGADTPP--GKPATGKLSFKE-----------------ALKVF-----GNRHTWILA 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 264 LVdvfvYMVRFG----MISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFVC 339
Cdd:TIGR00886 220 LL----YSVTFGsflgVSSIFAMLFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAFL 295
|
330 340
....*....|....*....|...
gi 446878488 340 LIGYWKSESLLMVTIFAAIVGCL 362
Cdd:TIGR00886 296 VVLGLVSDGSLAAFIVLFVALFF 318
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
30-204 |
2.13e-11 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 64.45 E-value: 2.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 30 ALLSVFLGYLAYYIVrnnfTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNV 109
Cdd:COG0477 19 LALGTFLEGLDFTIV----NVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 110 GLGFSSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNIShNVGGGIVAPIVGAAFAILGSEHWQSAS 189
Cdd:COG0477 95 LCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAA-IGLGLALGPLLGGLLVAALGWRWIFLI 173
|
170
....*....|....*
gi 446878488 190 YIVPACVAVIFALIV 204
Cdd:COG0477 174 NAPLGLLALVLRLRL 188
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
48-432 |
1.44e-10 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 62.70 E-value: 1.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 48 FTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWIFAALvvfn 127
Cdd:cd17371 18 LGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLIL---- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 128 GLFQGMGVGPSFIT----IANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGSEH-WQSASYivpacVAVIFAL 202
Cdd:cd17371 94 RALAGLGFGGEWAAgaalMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIaWRVLFL-----LGALPAL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 203 IVLVLGKGSPReeglpsleqmmPEEKVILKTKNTAKAPEnMSAWQIFCTYVLRNKNAWyiSLVDVFVYMVRFGMISWLPI 282
Cdd:cd17371 169 LVLFIRRFVKE-----------PPQWQAARAARRHFADR-PSLRELFSPPLLRTTLLA--SLLATGALGGYYGITTWLPS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 283 YLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRMPLAMI-CMALIFVCLIGYWKSESLLMVTIFAAIVGC 361
Cdd:cd17371 235 YLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRI--GRRNNFALFaLGSAISILLYFFLPLSPTLILILGFPLGFF 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446878488 362 LIYVPQFLASVQTmEIVPSFAVGSAVGLrgfmSYIFG---ASLGTSLFGVMVDKLGWYGGFyLLMGGIVCCILF 432
Cdd:cd17371 313 ASGPFSGMGAYLT-ELFPTAVRATAQGF----CYNVGriiGALFPFLVGFLATSGSLGTAI-AVFAAVYYIAGL 380
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
26-207 |
2.28e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 62.25 E-value: 2.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 26 YRIQALLSVFLGYLAYYIVRNNFTLSTPYL-KEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLC 104
Cdd:cd06173 205 RRSPLLRLLLLALALFALLGGALTVLLPLLaKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 105 AIVNVGLGFSSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGSeh 184
Cdd:cd06173 285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGL-- 362
|
170 180
....*....|....*....|...
gi 446878488 185 wqSASYIVPACVAVIFALIVLVL 207
Cdd:cd06173 363 --SAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
30-207 |
4.82e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 61.03 E-value: 4.82e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 30 ALLSVFLGYLAYYIVrnnFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNV 109
Cdd:cd17321 173 AVLAAFLLGAALGGL---LFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLL 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 110 GLGF---SSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGSEH-- 184
Cdd:cd17321 250 LLALlgaDSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSANlg 329
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 446878488 185 -----------------WQSASYIVPACVAVIFALIVLVL 207
Cdd:cd17321 330 dsgvaallsaaaaafaaGFHLAFLVAAALALLAALLALLL 369
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
48-414 |
7.62e-10 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 60.40 E-value: 7.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 48 FTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWIFAALVVFN 127
Cdd:cd06180 18 YTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 128 GLFQGMGVGPSFITIANWFPRRERGRVGAFwnISHNVGGGIVAPIVGAAFAILGSEHWQSAsYIVPACVAVIFALIVLVL 207
Cdd:cd06180 98 GAASAFVFVFGSNLVLHHATAAGRGHLIGL--LFAGVGLGIALSGLLVPAGLGGGLSWRAG-WLALALLSAVLLLLSFLL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 208 gkgSPREEGLPSlEQMMPEekvilktkntAKAPENMSAWQIFCTYVLRNknawyislvdvFVYMVrfgMISWLPIYLLtV 287
Cdd:cd06180 175 ---LRRGPSAPT-EASAAE----------SAPGLNRPLWRLALAYGLFG-----------FGYII---TATFLPLIAR-E 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 288 KHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRMPLAMICMALIFVCLIgywkseSLLMVTIFAAIVGCLIYVPQ 367
Cdd:cd06180 226 TGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRW--GTRRALAANLLVQAVGVLL------PLLSPGPAGLVLSAVLFGGT 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 446878488 368 FLASVQ-TMEIVPSFAVGSAVGLRGFM--SYIFGASLGTSLFGVMVDKLG 414
Cdd:cd06180 298 FMAITAlVMALARELAPPAAPRALALMtaSFGVGQILGPLLAGWLADATG 347
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
34-344 |
2.87e-09 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 58.80 E-value: 2.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 34 VFLGYLAYYIVRNNFTLSTPY-LKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLG 112
Cdd:cd17327 10 LCILYFLQYLDKSNISNAAVMgMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 113 FSSAFWIFAALVVFNGLFQGmGVGPSFI-TIANWFPRRERGRVGAFWNISHNVG---GGIVAPIVGAAFAILGSEHWQSA 188
Cdd:cd17327 90 AVKNFGGLIALRFFLGLFES-GVFPGFIlYLGMWYKREEQAKRIAFFYAAAGLGsifGGLLAYGVFKILGVGGLAGWRWL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 189 sYIVPACVAVIFALIVLVLGKGSPREEGLPSleqmmPEEKVILKT---KNTAKAPENMSAWQIFcTYVLRNKNAWYISLV 265
Cdd:cd17327 169 -FIIEGLITIIIGLVIFFWLPDNPSKAWFLT-----EEEKELAVErlrANQTGKGDQKFKWKQI-KEAFKDPRTWLLFLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 266 DVFVYMVRFGMISWLPIYLLTVKHFSKE--QMSVAFLFFEWAaipSTLLAGWLSDKLfkGRRMPLA--MICMALIFVCLI 341
Cdd:cd17327 242 FFCSQITNNGISNFLPLILKSLGFYSLQtnLLSVPIGALGAV---SLLIAALLSDRF--KKRGLFAifACVLALVGSIIL 316
|
...
gi 446878488 342 GYW 344
Cdd:cd17327 317 LAA 319
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
31-207 |
4.10e-09 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 57.97 E-value: 4.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 31 LLSVFLGYLAYYIVRNNFTLSTP-YLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADK----ASPKVFMACGLVLCA 105
Cdd:cd17319 181 VWGLALGYFGINYALYGLLTWLPtYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRllrgARRLVIIIGLLLAAV 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 106 IVnVGLGFSSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGSehw 185
Cdd:cd17319 261 GL-LLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGS--- 336
|
170 180
....*....|....*....|..
gi 446878488 186 QSASYIVPACVAVIFALIVLVL 207
Cdd:cd17319 337 YTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
262-435 |
5.56e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 57.43 E-value: 5.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 262 ISLVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFVCLI 341
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 342 GYWKSESLLMVTIFAAIVGCLIYVpqfLASVQTMEIVPSFAVGSAVGLRGfMSYIFGASLGTSLFGVMVDKLGWYGGFYL 421
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFP---AALALIADWFPPEERGRALGLVS-AGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170
....*....|....
gi 446878488 422 LMGGIVCCILFCYL 435
Cdd:pfam07690 157 LAILSLLAAVLLLL 170
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
66-432 |
8.82e-09 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 57.32 E-value: 8.82e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 66 IGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAF------WIFAALVVFNGLFQGMGvGPSF 139
Cdd:cd17342 65 LGVLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWlhfynkYLYCILWVLNGLLQSTG-WPCV 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 140 ITI-ANWFPRRERGRVGAFWNISHNVgGGIVAPIVGAAFAILGSEHwqsaSYIVPACVAVIFALIVLVLGKGSPreeglP 218
Cdd:cd17342 144 VAImGNWFGKSSRGFVLGLWSACASV-GNIIGALLASSVLDYGYEY----AFLVTSSLLFAGAIVVFFGLLSSP-----P 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 219 SLeqmmpeekvilktkntakapenmsawqIFCtyvlrnknawyiSLVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVA 298
Cdd:cd17342 214 GV---------------------------IPY------------SLAYACLKLVNYSFFFWLPFYLSNNFHWKESEADQL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 299 FLFFEWAAIPSTLLAGWLSDKLfkGRRMPLAMICMALIFVCLIGY------WKSESLLMVT-----------IFAAIVGC 361
Cdd:cd17342 255 SIWYDVGGIIGGIVAGYISDRM--GSRSPVVVVMLLLAIPSLFVYshspsdKVLNAFVMTItgffiggpanlISSAISAD 332
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446878488 362 LIYVPQFLASVQTMEIVPSFAVGSAVglrgfmsyiFGASLGTSLFGVMVDKLGWYGGFYLLMGGIVCCILF 432
Cdd:cd17342 333 LGRQPQLRGSSEALATVTGIIDGTGS---------IGAAIGQVLVPLIQNRLGWMWVFYFFIIMTILTIVC 394
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
25-410 |
1.37e-08 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 56.60 E-value: 1.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 25 RYRIQALLSVFLGYL--AYYIVRNNFTLstPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLV 102
Cdd:TIGR00895 13 RYQWRAIILSFLIMLmdGYDLAAMGFAA--PAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSIL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 103 LCAIVNVGLGFSSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVG---GGIVAPIVGAAFAi 179
Cdd:TIGR00895 91 LFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGaavGGFLAGWLIPVFG- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 180 lgsehWQSASYIvpacVAVIFALIVLVLGKGSPR------EEGLPSLEQMMPEEKVILKTKNTAKAPENMSAWQIFCTYV 253
Cdd:TIGR00895 170 -----WRSLFYV----GGIAPLLLLLLLMRFLPEsidflvSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 254 L------RNKNAWYISLVDVFVYMVRFGMISWLPiYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRMP 327
Cdd:TIGR00895 241 KalfqgkTARITVLLWLLYFMLLVGVYFLTNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRL--GPRVT 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 328 LAMICMALIFVCLIGYWKSESLLMVTiFAAIVGCLIYVPQFLASVQTMEIVPSFAVGSAVglrGFMSYI--FGASLGTSL 405
Cdd:TIGR00895 318 ALLLLLGAVFAVLVGSTLFSPTLLLL-LGAIAGFFVNGGQSGLYALMALFYPTAIRATGV---GWAIGIgrLGAIIGPIL 393
|
....*
gi 446878488 406 FGVMV 410
Cdd:TIGR00895 394 AGYLL 398
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
31-208 |
1.73e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 56.04 E-value: 1.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 31 LLSVFLGYLAYYIVrnnFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVG 110
Cdd:cd17473 203 YFLAFLAMLLFYVI---PIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 111 LGFSSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNvGGGIVAPIVGAAFAILGSEHwqSASY 190
Cdd:cd17473 280 LALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFF-LGQFLSPLVLGPLVNLTGGL--SGAF 356
|
170
....*....|....*...
gi 446878488 191 IVPACVAVIFALIVLVLG 208
Cdd:cd17473 357 LILGVLALVLAIVLLLLR 374
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
28-207 |
2.19e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 56.06 E-value: 2.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 28 IQALLSVFLGYLAYYIVrnnFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIV 107
Cdd:COG2211 231 LLLLLAYLLFFLALALV---AALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 108 NVGLGFS--SAFWIFAALVVFNGLFQGMGVGPSFITIAN-------WFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFA 178
Cdd:COG2211 308 LLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADvvdydewKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLA 387
|
170 180 190
....*....|....*....|....*....|....*.
gi 446878488 179 ILG--SEHWQSASYI-----VPACVAVIFALIVLVL 207
Cdd:COG2211 388 LFGyvAGAAQSPSALtgirlLFFLLPAVLLLLAALL 423
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
30-189 |
4.85e-08 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 54.89 E-value: 4.85e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 30 ALLSVFLGYLAYYIVrnnFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNV 109
Cdd:cd17503 183 GLLLSFLLGLGLFGA---MFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTL 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 110 GLGFSSAFWIFAALVVFNgLFQGMGVGPSFITIANWF----PRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGSEHW 185
Cdd:cd17503 260 LLAFLTPDTSLWLIILPL-FIRGLGMGLVFMPLNTLAlnslPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRTQFHH 338
|
....
gi 446878488 186 QSAS 189
Cdd:cd17503 339 SRLS 342
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
27-205 |
2.22e-07 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 52.81 E-value: 2.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 27 RIQALLSVFLGYLAYYIVRNNF-TLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASP-KVFMACGLVLC 104
Cdd:cd06174 201 KNPGLWLLLLAIFLVNLAYYSFsTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGrKPLLLIGLLLM 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 105 AIVNVGLGFSSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGSeh 184
Cdd:cd06174 281 ALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFG-- 358
|
170 180
....*....|....*....|.
gi 446878488 185 wQSASYIVPACVAVIFALIVL 205
Cdd:cd06174 359 -LTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
48-432 |
3.04e-07 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 52.23 E-value: 3.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 48 FTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWifaALVVFN 127
Cdd:cd17353 22 WSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLP---LLFLGY 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 128 GLFQGMGVGPSFITIAN----WFPRReRGRVGAFWNISHNVGGGIVAPIvgaAFAILGSEHWQSASYIVPACVAVIFALI 203
Cdd:cd17353 99 GVLGGIGAGIGYITPVStavkWFPDK-RGLATGIVIAGFGLGSLIFSPL---IAYLINTVGVPTTFLILGIIFLIIIVIG 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 204 VLVLGkgSPREEGLPsleqmmpeEKVILKTKNTAKAPENMSAWQifctyVLRNKNAWYISLVDVFVYMVRFGMISWLPIY 283
Cdd:cd17353 175 AFLIR--DPPKGWVP--------PGVDPLANNAENSPRDYTPRE-----MLRTPTFWLLWLMFFLNATAGLMLIGQAKPI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 284 LLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRMPLAMICMALIFVCLIGYWKSESLLMVTIFAAIV---- 359
Cdd:cd17353 240 GQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKI--GRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIgfcy 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446878488 360 -GCLIYVPQFLASVqtmeivpsFAVGSAVGLRGFM--SYIFGASLGTSLFGVMVDKLGWYGGFYLLMGGIVCCILF 432
Cdd:cd17353 318 gGGFALFPALTADF--------FGTKNAGTNYGLLytAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALAL 385
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
28-205 |
3.95e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 51.83 E-value: 3.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 28 IQALLSVFLGYLAYYIVrnnFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIV 107
Cdd:cd17316 180 LLLILLWFFISFGYYGL---TTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGIL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 108 NVGLGF---SSAFWIFAALVVFNGLFQGMGvGPSFITIANWFPRRERGR-VGAFWNIShNVGGGIVAPIVGaafAILGSE 183
Cdd:cd17316 257 ALPLFYllsGSPTLLLLLLFILSFFVGGVW-GALYAYLAELFPTEVRATgVGLSYNLG-RLGGGGAPPLIA---LLLAST 331
|
170 180
....*....|....*....|..
gi 446878488 184 HWQSASYIVPACVAVIFALIVL 205
Cdd:cd17316 332 GGTGVPALILALLAIVALIVAL 353
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
53-431 |
5.09e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 51.43 E-value: 5.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 53 PYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWIFAALVVFNGLFQG 132
Cdd:cd17365 23 PALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 133 mGVGPSFITI-ANWFPRRERGRVGAFWNISHNVGGGIVAPIvgaAFAILGSEHWQSASYIvpacvAVIFALIVLVLGKGS 211
Cdd:cd17365 103 -AAMPNAITLvSEYAPARRRSLAVTLMFCGYPLGAALGGFL---AAALIPAFGWRSVFLL-----GGVPPLILLPLLRGT 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 212 preeglpsleqmmpeekvilktkntakapenMSAWQIFctyvlrnknawYISLVDVFvymvrfGMISWLPiYLLTVKHFS 291
Cdd:cd17365 174 -------------------------------LLLWVTF-----------FMGLLLVY------LLNSWLP-KLMVEAGYS 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 292 KEQMSVAFLFFEWAAIPSTLLAGWLSDKlFKGRRMPLAMICMALIFVCLIGYwKSESLLMVTIFAAIVGCLIYVPQFLAS 371
Cdd:cd17365 205 LSQALTITLLLNIGGVIGSLLLGWLADR-FGPKRVLALFFALGAVSLALLGV-SPASLVLLYVLVFLAGACVNGAQVGLY 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446878488 372 VQTMEIVPSFAVGSAVGLRGFMSYiFGASLGTSLFGVMVD-KLGWYGGFYLLMGGIVCCIL 431
Cdd:cd17365 283 ALAARFYPTEVRATGVGWALGVGR-LGAILGPLLGGLLLAaGLGPESVFLALAIPAALGAL 342
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
48-438 |
5.53e-07 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 51.42 E-value: 5.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 48 FTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWIFAALVVFN 127
Cdd:cd17323 18 YSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 128 GLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVgGGIVAPIVGAafAILGSEHWQSASYIVPACVAVIFALIVLVL 207
Cdd:cd17323 98 GFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLL-GPALGPIIGG--FITQSLGWRWIFWFLAIISGFCLILIFLFL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 208 gkgspreeglpsleqmmPEekvilktkntakapenmsawqIFCTyvlrnknAWYISLVDVFVYMVRFGmiswLPIYLLTV 287
Cdd:cd17323 175 -----------------PI---------------------VLLL-------GLYVGLVYAILYLFLTA----FPYVFGEV 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 288 KHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGR------------RMPLAMICMALIFVCLIGY-W---KSESLLM 351
Cdd:cd17323 206 YGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLkkknggkpepeaRLPPAFIGAFLFPIGLFIFgWtiyPHIHWIV 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 352 VTIFAAIVGCLIYVPQFLASVQTMEIVPSFAVgSAVGLRGFMSYIFGAslGTSLFGV-MVDKLGwYGGFYLLMGGIVC-C 429
Cdd:cd17323 286 PIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAA-SALAANTLVRSIFAA--IFPLFAQpMFNNLG-VGWAFTLLAFISLaM 361
|
....*....
gi 446878488 430 ILFCYLSHR 438
Cdd:cd17323 362 IPIPFIFYK 370
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
30-436 |
6.81e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 51.04 E-value: 6.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 30 ALLSVFLGYLAYYIVrnnFTLSTPYLKEQLDLSAT--QIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIV 107
Cdd:cd17330 1 LFLVVFLDALGFGIV---FPVLPFYVREFNKLGASgyYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 108 NVGLGFSSAFWIFAALVVFNGLFQGmGVGPSFITIANWFPRRER----GRVGAFWNIshnvgGGIVAPIVGAAFAilgse 183
Cdd:cd17330 78 YVLLGLSRNLWLLFLARFLDGLTGG-NVSVAQAYIADITDEEERakafGIISAAFGL-----GFILGPALGGFLS----- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 184 hwQSASYIVPACVAVIFALIVLVLGkgspreeglpsleqmmpeeKVILKTkntakapenmsawqifctyvlrnknAWYIS 263
Cdd:cd17330 147 --TPYGYALPFLVAAALALLNLVLV-------------------LFFLPP-------------------------LRRLL 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 264 LVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFVCLIGY 343
Cdd:cd17330 181 LVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPF 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 344 WKSESLLMVTIFAAIVGCLIYVPQFLASVQtmEIVPSFAVGSAVGLRGFM---SYIFGASLGTSLFGVmvdklgWYGGFY 420
Cdd:cd17330 261 ASSVPLLVLAAAILAFGTGIVFPALSALLS--KSVPSKEQGKAQGIIQSLqslARIIGPLLAGPLYSF------LGPGVP 332
|
410
....*....|....*.
gi 446878488 421 LLMGGIVCCILFCYLS 436
Cdd:cd17330 333 FLLAAGLLLIALFLLS 348
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
13-204 |
7.44e-07 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 51.37 E-value: 7.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 13 KVPPEKVQATYGRYRIQALLSVFLGYLAYYIVrNNFTLStpYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKAS 92
Cdd:cd17369 216 RAPLVEVLRRHWRALLLAIGLRLAENVLFYLF-TTFALS--YATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVG 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 93 PKVFMACGLVLCAIVNV----GLGFSSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRER-GRVGAFWNISHNVGGG 167
Cdd:cd17369 293 RRPVYLAGALLAALFAFpffwLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRyTGASLGYQLGAILGGG 372
|
170 180 190
....*....|....*....|....*....|....*..
gi 446878488 168 IvAPIVGAAFAILGSEHWQSASYIVPACVAVIFALIV 204
Cdd:cd17369 373 F-APLIATALVAATGSWWPVALYLAALAVISLVAALF 408
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
54-214 |
1.22e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 50.62 E-value: 1.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 54 YLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWIFAALVVFNGLFQGM 133
Cdd:COG0738 236 YLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSL 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 134 GVgPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGsehwQSASYIVPACVAVIFALIVLVLGKGSPR 213
Cdd:COG0738 316 MF-PTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFG----LRAAFLVPLVCYLLILLLALALKRKRRK 390
|
.
gi 446878488 214 E 214
Cdd:COG0738 391 K 391
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
55-432 |
1.66e-06 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 49.88 E-value: 1.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 55 LKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWIFAALVVfnglfqgMG 134
Cdd:cd17339 25 IRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGGIALLFLGTAL-------AG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 135 VGpsfITIAN---------WFPRReRGRVGAFWNISHNVGGGIvAPIVGAAFAILGSEHWQSA--SYIVPACVAVIFALI 203
Cdd:cd17339 98 AG---IAVGNvllpslikrDFPRR-VGLMTGLYTTSMNLGAAL-ASGLSVPLAQALGGGWRGAlaIWALPALLALLIWLP 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 204 VLVLGKGSPreeglpsleqmmpeekvilkTKNTAKAPENmsawqifctyVLRNKNAWYISLVDVFVYMVRFGMISWLPIY 283
Cdd:cd17339 173 QLRRRKRAA--------------------AAAAPLTKIS----------VWRSPLAWQVTLFMGLQSLLFYTLMAWLPTI 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 284 LltVKH-FSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfKGRRmPLAMICMALIFVCLIG--YWKSESLLMVTIFAAIVG 360
Cdd:cd17339 223 L--IDAgLSAATAGWLLSLFQLVGIPASLLVPILATRL-KNQR-PIVVLLAVLFIIGVLGllFAPTALALLWAVLLGLGG 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 361 ------CLIYVPQFLASVQTmeivpsfavgsAVGLRGFMS---YIFgASLGTSLFGVMVDKLG-WYGGFYLLMGGIVCCI 430
Cdd:cd17339 299 gaafslALTLISLRSSDPAE-----------AAALSGMAQsvgYLL-AALGPLLFGVLHDLTGsWTAPLVLLLALTVLQL 366
|
..
gi 446878488 431 LF 432
Cdd:cd17339 367 VA 368
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
58-436 |
3.53e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.15 E-value: 3.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 58 QLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGF-----SSAFWIFAALVVFNGLFQG 132
Cdd:cd06173 28 QLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALlallgSLSLWLLLVLAFLLGIASA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 133 MGVGPSFITIANWFPRRERGRVGAFWNISHNVGGgIVAPIVGAAFAILGSEHWqsaSYIVPACVAVIFALIVLVLGKGSP 212
Cdd:cd06173 108 FFGPARQALLPELVPKEQLVRANALNSLATQLAR-IIGPALGGLLVALLGPGG---AFAINALSFLLSALLLLFIRRPPP 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 213 ReeglpsleqmmpeekvilktKNTAKAPENMSAWQIFCTYVLRNKNAWYISLVDVFVYMVRFGMISWLPIYLLTVKHFSK 292
Cdd:cd06173 184 A--------------------APGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 293 EQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFVcLIGYWKSESLLMVTIFAAIVGCLIYVPQFLASV 372
Cdd:cd06173 244 AGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALL-VLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLL 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446878488 373 QtmEIVPSFAVGSAVGLRGFMSYIFgASLGTSLFGVMVDKLGWYGGFYLLMGGIVCCILFCYLS 436
Cdd:cd06173 323 Q--LRVPDELRGRVFSVYNALNSGA-MPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
289-448 |
6.19e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 48.05 E-value: 6.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 289 HFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRmPLAMICMALIFVCLIGYWKSESLLMVTIFAAIVGCLIYVPQF 368
Cdd:COG2814 41 GASPAQAGLVVTAYLLGAALGAPLAGRLADRF--GRR-RVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 369 LASVQTMEIVPSFAVGSAVGLRGFMSYIfGASLGTSLFGVMVDKLGWYGGFYLLMGGIVCCILFCYLSHRGALELERQRQ 448
Cdd:COG2814 118 AALALIADLVPPERRGRALGLLGAGLGL-GPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARL 196
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
83-436 |
1.48e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.18 E-value: 1.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 83 VMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWifaALVVFNgLFQGMGVG---PSFIT-IANWFPRRERGRVGAFW 158
Cdd:cd17473 54 LAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLY---ALLASR-ALLGIGVAgimTLATAlIGDYFEGEERAKMLGLQ 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 159 NISHNVGGGIVAPIVGAafaiLGSEHWQSASYIVpaCVAVIFALIVLVLgkgspreeglpsLEQMMPEEKVILKTKNTAK 238
Cdd:cd17473 130 SAAMSLGGVVFLLLGGA----LAEIGWRAPFLVY--LLALPVLILVLLF------------LPEPARKSKSAASPGAATA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 239 APenmsawqifctyvLRNKNAWYISLVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSD 318
Cdd:cd17473 192 AA-------------LPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKR 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 319 KLFKGRRMPLAMICMALIFVcLIGYWKSESLLMVTIFAAIVGCLIYVPqfLASVQTMEIVPSFAVGSAVGLRGfMSYIFG 398
Cdd:cd17473 259 RLGKRRLLAIGFALMALGFL-LLALASGLWVVLLGAILAGLGFGLLLP--TLNSWAMSLVPPELRGRAMGIVT-SAFFLG 334
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 446878488 399 ASLGTSLFGVMVDKLGWYGGFYLLMGGI--VCCILFCYLS 436
Cdd:cd17473 335 QFLSPLVLGPLVNLTGGLSGAFLILGVLalVLAIVLLLLR 374
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
52-435 |
1.51e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 46.83 E-value: 1.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 52 TPYLKEqLDLSATQIGLlsscMLIAYGISK-------GVMSSLADKAspKVFMACGLVLCAIVNVGLGFSSAFWIFAALV 124
Cdd:cd17490 20 SPYAES-LGASLSMIGI----ILGAYGISQmllriplGILSDRIGKR--KLFIIIGLLFTVLASLIMILFPSPWGLLIAR 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 125 VFNGLFQGMGVgpSF-ITIANWFPRRERGRVGAFWNISHNVGggivaPIVGAAFAILGSEHWqsaSYIVPACVAVIFALI 203
Cdd:cd17490 93 FLSGIAAATWV--SFtVLYASYFPPDEAAKAMGLINLVNNLG-----QLIAFLIGGLIAEHF---GMRAPFLLAALAGVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 204 VLVLGkgspreegLPSLEQMMPEEKVILKTKNTAKapenmsawqifctyVLRNKNAWYISLVDVFVYMVRFGMI-SWLPI 282
Cdd:cd17490 163 GFILS--------LFIKEERREKKPVLTELKELLS--------------VLKDKKLLFFSLLAILQQMITFSTTfGFTPL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 283 YL--LTVKHFSKEQMSVAFLFFewaAIPSTLLAGWLSDKLFKGRRmpLAMICMALIFVC--LIGYWKSESLLMVTIFAAI 358
Cdd:cd17490 221 IAkqLGASSFQLGLLSIIYLLP---NALASLLSGTLFYKKLGERN--TIIIGFLLLGAYcfLIPFAPNLTLLYLLQALNG 295
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446878488 359 VGCLIYVPQFLASVqtMEIVPSFAVGSAVGLrgFMS-YIFGASLGTSLFGVMVDKLGWYGGFYLL-MGGIVCCILFCYL 435
Cdd:cd17490 296 FGTGILFPLLMSLS--IEGVPAEQRSTAMGF--FQAiYALGMFLGPVLVGIISEAFGLQTGFFVIgVIALLAAILSLAY 370
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
31-405 |
1.85e-05 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 46.40 E-value: 1.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 31 LLSVFLGYLAYYIVrnnfTLSTPYLKEQLDlSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVG 110
Cdd:cd17502 2 MLALFLAALDQTIV----ATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 111 LGFSSAFWifaALVVFNGLfQGMGVGP----SFITIANWFPRRERGRVGAFWNISHNVGGgIVAPIVGAAFAILGSEHWq 186
Cdd:cd17502 77 CGLAPNMT---MLIVGRAI-QGIGGGGlmslAFIIIADLVPPRERGKYQGYIGAVFGIAS-VAGPLIGGAFTDHLSWRW- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 187 sasyivpacvavIFaLIVLVLGkgspreeglpsleqmmpeekvilktkntakapenmsawqIFCTYVLRNknAWYISLVD 266
Cdd:cd17502 151 ------------CF-YINLPIG---------------------------------------GLALALLRT--ILLSSIFG 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 267 VFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRR-MPLAMICMALIFVCLIGYWK 345
Cdd:cd17502 177 FLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPlIVIGTILMSVGAGLLTTLTL 256
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446878488 346 SESLLMVTIFAAIVGCL--IYVPQFLASVQtmEIVPSFAVGSAVGLRGFMSYIfGASLGTSL 405
Cdd:cd17502 257 DTSKWLLIGYLILLGLGlgIGFQQPLVAVQ--NAVPPADVGVATATNTFFRSL-GGTLGVAI 315
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
57-205 |
2.60e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.38 E-value: 2.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 57 EQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWIFAALVVFNGLFQGMGVG 136
Cdd:cd17370 227 QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQES 306
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 137 PSFITIANWFPRRERGRV-GAFwnishNVGGGIVAPIVGAAFAILGSEHWQSASYIVPACVAVIFALIVL 205
Cdd:cd17370 307 IERAAVADLVPAELRGTAyGLF-----NTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
34-433 |
5.32e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 45.39 E-value: 5.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 34 VFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGF 113
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 114 SSAFWIFAALVVFNGLFQGM---GVGPSFITIANWFPRRERGRVGAFWNIshnvgGGIVAPIVGAAFaiLGSEHWQSASY 190
Cdd:cd17333 81 TPSIYLFVVLMFLAGLGAGIldtGANTFVGALFEESSATRLNVLHGFFGL-----GALIGPLIATSL--LTSELSWSWAY 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 191 IVPACVAVIFALIVLVLGKgspreeglpsleqmMPEEKVILKTKNTAKAPENMSAwqifctyVLRNKNAWYISLVDVFVY 270
Cdd:cd17333 154 LIIGLIYLLLAILILLTLF--------------PELPSARNPQQSVGAFSASASR-------LLRNPSIILGALALFLYV 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 271 MVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKlFKGRRMPLAMICMALIFVCLIGYWKSESLL 350
Cdd:cd17333 213 GAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRR-IKPHTLLVLSGSGALLGLLILLLAPTLVVG 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 351 MVTIFAAIVGCLIYVPQFLAsvQTMEIVPsFAVGSAVGLrgfmsYIFGASLGTSLFGVMVDKLGWYGGFY--LLMGGIVC 428
Cdd:cd17333 292 LVATALLGLFMAALFPTILS--LGISNLP-YAKGKGTSV-----LLAAGSIGGAIIPFIMGFIAEAVGIQtaMLLITILY 363
|
....*
gi 446878488 429 CILFC 433
Cdd:cd17333 364 AIIFV 368
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
254-435 |
6.03e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.28 E-value: 6.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 254 LRNKNAWYISLVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFK--GRRMPLAMI 331
Cdd:COG2211 7 LSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTrwGRRRPWILI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 332 CMALIFVCLIGYWKSESLLMVTIFAAIVGCLIyvpqFLASVQTMEIVPSFAVG-----------SAVGLRGFMSYIfGAS 400
Cdd:COG2211 87 GAIPLALSFVLLFTAPDLSPTGKLIYALVTYL----LLGLAYTLVNIPYSALGaeltpdyeertRLSSWRFAFAGL-GGL 161
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 446878488 401 LGTSLFGVMVDKLG-----WYGGFYLLMGGI-VCCILFCYL 435
Cdd:COG2211 162 LASVLPPPLVAAFGgdaalGYRLTALIFAVLgLLAFLLTFF 202
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
54-434 |
1.02e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 44.50 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 54 YLKeQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKAS-PKVFMACGLVLCAIVNVGLGFSS-AFWIFAALVVFNGLFQ 131
Cdd:cd17335 23 YLK-QLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFFVAqIFWLLLLLVILGAFFS 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 132 GMGVgPSFITIANWFPRRERGRVGA--FWNishNVGGGIVAPIVGAAFailgsEHWQSASYIVPA-CVAVIFALIVLVLG 208
Cdd:cd17335 102 APVV-PLVDSITLQYLGEERERYGKqrLWG---SIGFGIAALLVGILI-----DRSSTYKNYTIAfYVFAVLMLLALLLA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 209 KgspreeglpsleqmmpeeKVILKTKNTAKAPENMSAWQIfctyvLRNKNAWyislvdVFVYMVRFGMISWLPIYLLTVK 288
Cdd:cd17335 173 L------------------KFPFRPKHPEPNENTGGLLAL-----LRNPRVL------AFLLVAFLMGFGHGLIYSFLFW 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 289 HF-----SKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFVcLIGYWKSESLLM-------VTIFA 356
Cdd:cd17335 224 HLqdlggSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWL-LYSFLENPWLVLpiellhgLTFAL 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446878488 357 AIVGCLIYVPQflasvqtmeIVPSFAVGSAVGLRGFMSYIFGASLGTSLFGVMVDKLGWYGGFyLLMGGIVCCILFCY 434
Cdd:cd17335 303 VWAAAVSYASA---------AAPPGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTF-RFFAIAALAGLLAF 370
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
60-208 |
1.18e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 44.12 E-value: 1.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 60 DLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWIFAALVVFNGLFQGMGVgPSF 139
Cdd:cd17489 223 ERGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLF-PAL 301
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 140 ITIA-NWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGsehwQSASYIVPACVAVIFALIVLVLG 208
Cdd:cd17489 302 QALAvDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG----YRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
53-416 |
1.20e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 44.10 E-value: 1.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 53 PYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWIfaaLVVFNgLFQG 132
Cdd:cd17503 20 PTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLAS---LIIFR-ILQG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 133 MGVGP----SFITIANWFPRRERGRVGAFWNIshnvgGGIVAPIVGAAF--AILGSEHWQSASYI-VPACVAVIFALIVL 205
Cdd:cd17503 96 FGGGVliplAQTILLRIYPPEKRGAAMGLVGL-----VILLAPAIGPTLggWLTDNLSWRWIFYInLPIGILALLLAPLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 206 VLGkgspreeglpsleqmmpeekvilktkntakapenmsawqifctyVLRNKNAWYISLVDVFVYMVRFGMISWLPIYLL 285
Cdd:cd17503 171 DLR--------------------------------------------LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQ 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 286 TVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFVCLIGYWKSESLLMVTIFAAIVGC---L 362
Cdd:cd17503 207 NVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLgmgL 286
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 446878488 363 IYVPqflASVQTMEIVPSFAVGSAVGLRGFMSyIFGASLGTSLFGVMVDKLGWY 416
Cdd:cd17503 287 VFMP---LNTLALNSLPPEQIGDATALFNTIR-QLGGSIGTALLATLLTNRTQF 336
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
53-212 |
2.08e-04 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 43.76 E-value: 2.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 53 PYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWIFAALVVFNGLfqg 132
Cdd:PLN00028 60 PIIRDNLNLTKSDIGNAGIASVSGSIFSRLAMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFIAVRFFIGF--- 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 133 mgVGPSFITIANW----FPRRERGRVGAF---WNishNVGGG---IVAPIVGAAFAILGSEHWQS--ASYIVPACVAVIF 200
Cdd:PLN00028 137 --SLATFVSCQYWmstmFNGKIVGTANGIaagWG---NLGGGvtqLLMPLVFPLIKDAGAPSFTAwrIAFFVPGLLHIIM 211
|
170
....*....|..
gi 446878488 201 ALIVLVLGKGSP 212
Cdd:PLN00028 212 GILVLTLGQDLP 223
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
25-206 |
2.16e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 43.30 E-value: 2.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 25 RYRIQALLSVFLGYLAYYIVRNNFTLSTP-YLKEQLDLSATQIGLLSSC--------MLIAygiskGVmssLADKASPKV 95
Cdd:cd17471 195 APVNRRLLLLFAAFTLLFAANSMYIIAMPlYVTNELGGSESWVGLLFGLaaaleipiMLLA-----GL---LAKRFGKRR 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 96 FMACGLVLCAIVNVGLGFSSAFWIFAALVVFNGLFQG--MGVGpsfITIANWFPRRERGRVGAFWNISHNVGGGIVAPIV 173
Cdd:cd17471 267 LLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGitAGLG---ISYFQDLMPGQPGLATTLYSNASRIGSLLGGLLA 343
|
170 180 190
....*....|....*....|....*....|...
gi 446878488 174 GAAFAILGsehwQSASYIVPACVAVIfALIVLV 206
Cdd:cd17471 344 GVIAQYFG----YRAVFLVCAVLALL-ALVLLL 371
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
83-360 |
4.50e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 42.45 E-value: 4.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 83 VMSSLAD-KASPKVFMACGLVLCAIVNVGLGFSSAFWIFAALVVFNGLFQGMGVGPSFI-----TIAnwfPRRERGRVGA 156
Cdd:COG2270 71 VLGAIADrSGRKKPFLAFFTLLGVLATAALFFVAPGGLWLGLLLFVLANIGFEGSLVFYnaflpDIA---TPEEIGRVSG 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 157 FwnishnvG------GGIVAPIVGAAFAI----LGSEHWQSASYIVPACVAV---IFALIVLVLGKGSPREEGLPSLEQM 223
Cdd:COG2270 148 L-------GwalgylGGVLLLLINLALFLkpeaFGLPDAGEAVRISFLLTALwwlLFALPLFLFLPERPRPGPAPPRGAV 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 224 MPEEKVILKTKNTAKAPENMsawqifctyvlrnknAWYisLVDVFVY-MVRFGMISWLPIYLLTVKHFSKEQMSVAFLFF 302
Cdd:COG2270 221 RAGFRELRRTLRELRRYRDL---------------LRF--LLAYFFYrDGVQTVIAFAGIYAAGVLGFSTTELIVFGLLV 283
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 446878488 303 EWAAIPSTLLAGWLSDKLfkGRRMPLAMICMALIFVCLIGYWkSESLLMVTIFAAIVG 360
Cdd:COG2270 284 QIVAALGALLFGRLDDRI--GPKRVILVSLVIWIVVCLAAYF-LTTALAFWILGLLIG 338
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
267-457 |
6.07e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 41.84 E-value: 6.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 267 VFVYMVRFGMISWLPiYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRMPLA--MICMALIFVcligyw 344
Cdd:cd17475 6 AAASLVAQGIPALAP-FLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRF--GERRVLAvgLLLMGAAAL------ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 345 kseSLLMVTIFAAIVGCLIYVPQFLASVQ------TMEIVPSFAVGSAVGLRGfMSYIFGASLGTSLFGVMVDKLGWYGG 418
Cdd:cd17475 77 ---LMALVGSYPVLLVLLFLVGAGYGSVQpgggraIMRWFPPRERGLAMGIRQ-TGVPLGGALAAALLPPLALHYGWRAA 152
|
170 180 190
....*....|....*....|....*....|....*....
gi 446878488 419 FYLLMGGIVCCILFCYLSHRGALELERQRQNALHNQDSL 457
Cdd:cd17475 153 FVVAGLVSILAAVLFWLFYREPPAASAATESASTLLRSL 191
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
53-213 |
6.09e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 41.78 E-value: 6.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 53 PYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWIFAALVVFNGLFQG 132
Cdd:cd17359 25 PFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 133 MGVGPSFITIANWFPRRERGRVGAFWNIShNVGGGIVAPIVGAAFAILGSEHWQSAS---YIVPACV--AVIFALIVLVL 207
Cdd:cd17359 105 GASALVPMYIAEVAPAEIRGRLVSLNQLM-IVFGQLLAYIVNYLIANAGGADWLGAEgwrWMLGLEAipAILFLLGMLFI 183
|
....*.
gi 446878488 208 GKgSPR 213
Cdd:cd17359 184 PE-SPR 188
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
53-209 |
6.32e-04 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 41.83 E-value: 6.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 53 PYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWIFAALVVFNGLFQG 132
Cdd:cd17390 20 STHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKH 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 133 -MGVGPSFitIANWFPRRER----GRVGAFWNIshnvgGGIVAPIVGAAFAilgseHWQSASYIVPACVAVIF---ALIV 204
Cdd:cd17390 100 tQSLCKAY--LSDLVSEQERsrvlGRFNAASSL-----GFILGPVVGGHLA-----ETDGGFYYVALLCSAIFilnAGLV 167
|
....*
gi 446878488 205 LVLGK 209
Cdd:cd17390 168 WFLLS 172
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
262-435 |
6.98e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.81 E-value: 6.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 262 ISLVDVFVYMVRFGMISWLPIYLLTvKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLfkGRRmPLAMICMALIFVCLI 341
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRF--GRK-RLLLIGLLIFALATL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 342 GYWKSESLLMVTIFAAIVGclIYVPQFLASVQT--MEIVPSFAVGSAVGLRGFMSYIfGASLGTSLFGVMVDKLGWYGGF 419
Cdd:cd17489 77 LYLLATSVALLLVLRLIHG--IGWGAFTTAAATlvADIIPPSRRGEGIGYYGLATTL-AMALGPALGLFLYQHLGFAVLF 153
|
170
....*....|....*.
gi 446878488 420 YLLMGGIVCCILFCYL 435
Cdd:cd17489 154 IVAAVLALLALLLVFL 169
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
48-432 |
9.57e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 41.37 E-value: 9.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 48 FTLSTPYLKEqLDLSATQIGLLSSCM-LIAYgISKGVMSSLADK-ASPKVFMACGLVLCAIVNVGLGFSSAFWIFAALVV 125
Cdd:cd17370 19 RSILPLFLVV-LGASAAAVGLIEGLAeALGS-LLRLFSGYLSDRtGKRKPLVILGYGLSALAKPLLALAGSWQLVLLLRI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 126 FNGLFQGMGVGPSFITIANWFPRRERGRvgAF-WNISHNVGGGIVAPIVGAAFAILGSEHWQSASYI--VPAcvavIFAL 202
Cdd:cd17370 97 LERLGKGIRTPPRDALLADATPPSGRGK--AFgLHRALDTLGAVLGPLLAALLLYLLGGNYRTIFLLaaIPA----LLAL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 203 IVLVLGKgspreeglpsleqmmpeekvilKTKNTAKAPENMSAWQIFctyVLRNKNAWYISLVdVFVYMvrFGMISW-LP 281
Cdd:cd17370 171 LILLFVV----------------------KEYPRPPKLRKKSKKTSL---KKLPKAFWLYLLA-VALFA--LGNFSFaFL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 282 IYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMALIFVCLIGYWKSESLLMVTIFAAIvgc 361
Cdd:cd17370 223 ILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGL--- 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446878488 362 liyvpqFLASVQTME------IVPSFAVGSAVGLRGFMsYIFGASLGTSLFGVMVDKLGWYGGFYLLMGGIVCCILF 432
Cdd:cd17370 300 ------YMGAQESIEraavadLVPAELRGTAYGLFNTV-VGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
|
|
| MFS_NHS |
cd06177 |
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The ... |
53-418 |
1.56e-03 |
|
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The prototypical members of the Nucleoside:H(+) symporter (NHS) family are Escherichia coli nucleoside permease NupG and xanthosine permease. Nucleoside:H(+) symporters are proton-driven transporters that facilitate the import of nucleosides across the cytoplasmic membrane. NupG is a broad-specificity transporter of purine and pyrimidine nucleosides. Xanthosine permease is involved in the uptake of xanthosine and other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. The NHS family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340866 [Multi-domain] Cd Length: 386 Bit Score: 40.69 E-value: 1.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 53 PYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADK--ASPKVFMACGLVlCAIVNVGLGFSSAFWIFAALVVFNGLF 130
Cdd:cd06177 22 GYMGSTLGFTGAQIGAVYSTTGIAAIIMPFFLGIIADRffAAEKVLAVLHLI-GAAALFYAATVTDFSVFFWVMLLYSLC 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 131 Q----GMGVGPSFITIANwfPRRERGRVGAFWNIshnvgGGIVApivGAAFAILGSE--HWQsasYIVPACVAVIFALIV 204
Cdd:cd06177 101 YmptlALTNSIAFSNLED--PVKDFPPIRVWGTI-----GWIAA---GWPVGFLGWEasNLQ---FYIAAGASLLLGLYS 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 205 LVLGKGSPREEGLPS--LEQMMPEEKVILKTKNTAkapenmsawqIF--CTYVLRNKNAWYISLVDVFVYmvRFGMISWL 280
Cdd:cd06177 168 LTLPHTPPKKAGKGVskRSLLGLDAFVLLKNPFFA----------VFfiFSFLLGAPLQFYYTFANPFLN--DFGMIVKN 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 281 PIYLLTVKHFSKeqmsvaFLFFewAAIPSTLlagwlsDKLFKGRRMPLAMICMALIFVCLIgyWKSESLLMVTIFAAIVG 360
Cdd:cd06177 236 PAGIMSLGQISE------ILFM--LAIPFFL------KRLGIKKVMLIGMLAWVLRFGLFA--YGDPSPGVWMLVLSIIL 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 361 CLIYVPQFLASVQ--TMEIVPSFAVGSAVGLRGFMSYIFGASLGTSLFGVMVDKLGWYGG 418
Cdd:cd06177 300 HGVCYDFFFVTGYiyVDKKAPKDIRASAQGLFMLMTNGVGALVGSILSGKVVDKFTTVEG 359
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
51-361 |
2.37e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 39.91 E-value: 2.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 51 STPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIVNVgLGFSSAFWIFAALVV---FN 127
Cdd:cd17318 43 TLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTL-LTPLAARGGYGALIVlriLQ 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 128 GLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGsehWQSASYIVpACVAVIFALIVLVL 207
Cdd:cd17318 122 GLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLG---WPSIFYIF-GGLGLLWCLLWFFL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 208 GkgspreeglpsleqmmpeekvilktkntakapenMSAWQIFCTYVLRNKnAWYIslvdvfvymvrfgMISWLPIYLLTV 287
Cdd:cd17318 198 V----------------------------------LPVWAIVVAHFGHNW-GFYT-------------LLTELPTYMSDV 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 288 KHFSKEqmSVAFL----FFewAAIPSTLLAGWLSDKLFKGRRMPL-----AMICMALIF--VCLI--GYWKSESLLMVTI 354
Cdd:cd17318 230 LHFNIK--SNGFLsslpYL--AMWICSIVGGYLADWLRSRGILSTttvrkLFTSIGFLGpgVFLIalGYLGSNATLAVVF 305
|
....*..
gi 446878488 355 FAAIVGC 361
Cdd:cd17318 306 LTLSVGL 312
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
87-432 |
2.66e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 40.11 E-value: 2.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 87 LADKASPKVFMACGLVLCAIVNVGLGFSSAfwIFAALVVFNGLFQGMGVGP----SFITIANWFPRRERGRVGAFWNISH 162
Cdd:TIGR00894 99 LAGKYVFKWSIGIGMFLSSVISIVIPWAAG--GGIALVVFCRVIQGLAQGSvspaTHKIIVKWAPPKERSRLLGMSTSGF 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 163 NVGGGIVAPIVG-AAFAILGsehWQSASYIVPACVAVIfALIVLVLGKGSPREEGLPSLEqmmpEEKVILKTKNTAKAPe 241
Cdd:TIGR00894 177 QLGTFIFLPISGwLCESWGG---WPMIFYVFGIVGCAW-SLLWFVFPADDPSIHPCISKF----EKKYINSSLQGQKGS- 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 242 nmSAWQIFCTYVLRNKNAWYISLVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLF 321
Cdd:TIGR00894 248 --TRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLK 325
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 322 KGRRMPLAM---ICMALIFVCLI-----GYWKSESLLMVTIF---AAIVGCLIYVPQFLASVQTMEIVPSFaVGSAVGLR 390
Cdd:TIGR00894 326 SSKTLSLTAarkIFNGIGGLGPGifayaLPYLSAAFYLTIIIltlANAVSSGPLAGVLINSLDLAPRFLGF-IKGITGLP 404
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 446878488 391 GFMSYIFgASLGTSLFGVMVDKLGWYGGFYLLMGGIVCCILF 432
Cdd:TIGR00894 405 GFIGGLI-ASTLAGNILSQDSKNVWLIVFLIMAFVNILCVIF 445
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
28-207 |
3.48e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 39.48 E-value: 3.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 28 IQALLSVFLGYLAYYIVRNNFTLSTPYLkeqLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVLCAIV 107
Cdd:cd17504 184 ITALLAGFGMFMVFQLLPQLLQLPTPTG---FGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVG 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 108 NVGLGF-SSAFWIFAALVVFNGLFQGMGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFA-----ILG 181
Cdd:cd17504 261 LLLLALlHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTtytvsITS 340
|
170 180
....*....|....*....|....*.
gi 446878488 182 SEHWQSASYIVPACVAVIFALIVLVL 207
Cdd:cd17504 341 GGVPTEGAYVLAFLIGAALALAALLL 366
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
54-432 |
3.65e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 39.45 E-value: 3.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 54 YLKEQLDLSATQIGLLSSCM-LIAYGISKgVMSSLADKASP-KVFMACGLVLCAIVNVGLGFSSAFWIFAALVVfngLFQ 131
Cdd:cd17471 22 FLTEELGASPLQIGIFMTLSaLSGIVVSQ-WLGRLSDRGGDrKPLILLALLAGALGYLLFAFLRNYWVLLLVGV---VLL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 132 GMGvGPSF---ITIANWFPRRERGRVGAFWNISHNVG---GGIVAPIVGAAFAILGSEHWqsaSYIVPACVAVIFALIVL 205
Cdd:cd17471 98 SLG-AAAFpqlFALAREYADRSSGRDATLFNSVLRAAfslAWVIGPPLAFLLLDVLGFTG---LFLLAALLYLVVALLVL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 206 VLGKGSPREEGlpsleqmmpeekvilktkNTAKAPENMSAWqifctyvlRNKNAWYISLVDVFVYMVRFGMISWLPIYLL 285
Cdd:cd17471 174 FLLPSVKPPAQ------------------KATPASSLVKAP--------VNRRLLLLFAAFTLLFAANSMYIIAMPLYVT 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 286 TVKHFSKEQMSVAF---LFFEwaaIPSTLLAGWLSDKLFKGRRMPLAMICMALIFvclIGYWKSESLLMV-------TIF 355
Cdd:cd17471 228 NELGGSESWVGLLFglaAALE---IPIMLLAGLLAKRFGKRRLLLAGFLAGVLFY---LGLALATSLWQLialqllnAIF 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446878488 356 AAIVGCL-IYVPQFLASVQtmeivpsfaVGSAVGLRGFMSYIfGASLGTSLFGVMVDKLGWYGGFYLLMGGIVCCILF 432
Cdd:cd17471 302 IGITAGLgISYFQDLMPGQ---------PGLATTLYSNASRI-GSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVL 369
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
32-140 |
3.74e-03 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 39.51 E-value: 3.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 32 LSVFLGYLayyivrnNFTLStPYLkEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKAS-PKVFMACGLVLCAIVNVG 110
Cdd:cd17385 213 GSVSLGFL-------DPTLS-PHL-RQFKLSPGQVGLMFLILAGSYAISAPLWGWLSDKKKiPKWLMVIGSIITGVGFLL 283
|
90 100 110
....*....|....*....|....*....|....*.
gi 446878488 111 LG------FSSAFWIFAALVVFNGLFQGMGVGPSFI 140
Cdd:cd17385 284 LGpapllpIKSELWMVIIGLVLLGLSLGAALVPTFP 319
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
54-209 |
6.52e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.71 E-value: 6.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 54 YLKEQLDLSATQIGLLSSCMLIAYGISKG-VMSSLADKASPKVFMACGLVLCAIVNVGLGFSSAFWIFAALVVFNGLFQG 132
Cdd:cd17330 200 FLKDRFGFSPSQIGLLLALVGIAGILAQLlLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTG 279
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446878488 133 MGVGPSFITIANWFPRRERGRVGAFWNISHNVGGGIVAPIVGAAFAILGsehwqsaSYIVPACVAVIFALIVLVLGK 209
Cdd:cd17330 280 IVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLG-------PGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
94-363 |
6.53e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 38.74 E-value: 6.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 94 KVFMACGLVLCAIVNVGLGFSSAFWIFAALVVFNGLFQGMGVGPSFITI--ANWFPR-----RERGRVGAFWNISHNVGG 166
Cdd:cd17332 70 RPWLLWGAIPLALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIpyTALIPEltddpEERTSLTSWRMFFATIGG 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 167 GIVAPIVGAAFAILGSEHWQSASYIVPACVAVIFALIVLVLGKGSpREEGLPSleqmmPEEKVILKTKNTAKapenmsaw 246
Cdd:cd17332 150 LLVTVLPPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICFFGT-RERVVPP-----EEEKSKLPLLKSLK-------- 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 247 qifctYVLRNKNAWYISLVDVFVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFewAAIPSTLLAGWLSDKLFKGRRm 326
Cdd:cd17332 216 -----ALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLIL--SGALLALLPWPPLKKRFGKKK- 287
|
250 260 270
....*....|....*....|....*....|....*..
gi 446878488 327 pLAMICMALIFVCLIGYWKSESLLMVTIFAAIVGCLI 363
Cdd:cd17332 288 -AFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGI 323
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
35-426 |
7.93e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 38.30 E-value: 7.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 35 FLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVL--CAIVNVGLG 112
Cdd:cd17380 5 FLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALwsLATLLTPLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 113 FSSAFWIFAALVVFNGLFQGMGVgPSFITI-ANWFPRRERGRVGAFWNISHNVG---GGIVAPIvgaafaILGSEHWQSA 188
Cdd:cd17380 85 AYSSLPLLILSRILLGLGEGVHF-PSMTSLfSRWVPVSERSRAVSIVTAGSYLGtllGGLIGPL------LLEYYGWPSV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 189 SYIVPACvAVIFALIVLVLgkgspreeglpsleqmmpeekvilktkntakapeNMSAWQI----FCtyvlrNKNAWYIsl 264
Cdd:cd17380 158 FYFFGLL-GLLWALVWLIY----------------------------------LPPVWAIivahFC-----MNWGFYI-- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 265 vdvfvymvrfgMISWLPIYLLTVkhFSKEQMSVAFLFFEW-AAIPSTLLAGWLSDKLFKgRRMPLA-----MICMAL--- 335
Cdd:cd17380 196 -----------LLSWLPTYFHEV--LVPLAKGWVFNVVPWlVMFPSSNVAGWLADHLIS-RGWTVTsvrklMQSIGFlgp 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 336 -IFVCLIGYWKSESLLMVTIFAAIVGCLIYVPQFLASVQtmEIVPSFAvGSAVGLRGFMSYIFGAsLGTSLFGVMVDKLG 414
Cdd:cd17380 262 aLFLLLLSHTDSFSLALLCMSVALGLSAFSSSGVLVNHQ--DIAPNYA-GIVFGISNTAGTIPGI-VGVYLTGYILEATG 337
|
410
....*....|..
gi 446878488 415 WYGGFYLLMGGI 426
Cdd:cd17380 338 SWSLVFVLAAVV 349
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
53-281 |
8.01e-03 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 38.75 E-value: 8.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 53 PYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKASPKVFMACGLVlcaiVNVGLGFSSAFWIFAALVVFNGLFQG 132
Cdd:cd17438 23 PSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLA----INASFAFLSSFVQGYGAFLFCRLISG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 133 MGVGPS----FITIANWFPRRERGR----VGAFWNIshnvgGGIVA--------PIVGAAFAILGSEHWQSASYIVPACV 196
Cdd:cd17438 99 FGIGGSlpivFAYFSEFLAREKRGEhlswLCMFWMI-----GGLYAsamawsiiPHYGWGFSMGTNYHFHSWRVFVIICA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 197 -AVIFALIVLVLGKGSPR---EEGlpsleqMMPEEKVILKTKNTAKAPENMSAWQIFCTYVLRNKNAWYISLVDVFVYMV 272
Cdd:cd17438 174 lPCIASIIALKFMPESPRfllEMG------KHDEAWMILKNIHDTNMRAKGTPEKVFTVSNIKRKNTLFLAVVWFTMAFS 247
|
....*....
gi 446878488 273 RFGMISWLP 281
Cdd:cd17438 248 YYGLTVWFP 256
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
32-432 |
8.15e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 38.39 E-value: 8.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 32 LSVFLGYLAYYIVRNNFTLSTPYLKEQLDLSATQIGLLSSCMLIAYGISKGVMSSLADKA-SPKVFMACGLVLCAIVnVG 110
Cdd:cd17393 2 LAVAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFgSRRVTRLGALLLLLAL-LL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 111 LGFSSAFWIFA-ALVVFNGLFQGMGVGPSF--ITIANWFPRRERGRVGAFWNIshnvgGGIVAPIVGAAFAILGSEHWqs 187
Cdd:cd17393 81 LGLAPSVPALAlALFLFGAANGALDVAMNAqgVAVERAYGRPIMSSLHAMWSL-----GGLAGALLGAAAIGAGVSPG-- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 188 ASYIVpacVAVIFALIVLVLGKGSPREEGLPSLEQMMPEEKVILktkntakapenmsawqifctyVLRNKNAWYISLVDV 267
Cdd:cd17393 154 VHLLA---AAVLLLLAALVAIRALLPGTGEAAEDRPDGAGKPGF---------------------LLPNRLLLLLGLLAL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 268 FVYMVRFGMISWLPIYLLTVKHFSKEQMSVAFLFFEWAAIPSTLLAGWLSDKLFKGRRMPLAMICMAL-IFVCLIGYWks 346
Cdd:cd17393 210 AAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALgLLLALLAPS-- 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 347 eslLMVTIFA-AIVGCLI--YVPQFLASVQTMeivPSFAVGSAVGLRGFMSYIfGASLGTSLFGVMVDKLGWYGGFYLLM 423
Cdd:cd17393 288 ---VWVALAGfALMGLGLsvVVPLAFSAAGAL---PGLAAGIAVARVATLGYL-GFLVGPPLIGFLADATGLRTAFLVVA 360
|
....*....
gi 446878488 424 GGIVCCILF 432
Cdd:cd17393 361 LLALLVALL 369
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
166-435 |
9.10e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 38.35 E-value: 9.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 166 GGIVAPIVGAAFAILGSEHwqsasyiVPACVAVIFALIVLVLgkgspreeglpsLEQMMPEEKvilKTKNTAKAPENMSA 245
Cdd:cd17331 134 GMVVGSFLGGLLTKKFGEQ-------AAALVAAVGSLLSIVL------------VILLIPSNT---KSKREKEAKESASP 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 246 WQIF----CTYVLRNKNAWYISLVDVFVYMVrFGMI-SWLPIYLLTVKHFSKEQ----MSVAFLFfewAAIPSTLLAGWL 316
Cdd:cd17331 192 PSVFnlkeILRLLRLPGVAFLLLVKLLSGLP-IGMFqSMFSLVAMDFFGLTPEEngylMSYAGVL---GMVVQGLLVGPL 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446878488 317 SDKLFKGRRMPLAMICMALIFVCLIGYWKSESLLMVTIFAAIVGCLIYVpqfLASVQTMEIVPSFAVGSAVGLRGFMSYi 396
Cdd:cd17331 268 TKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYT---VITSLLTKAVPPEDTGTALGLSHALFS- 343
|
250 260 270
....*....|....*....|....*....|....*....
gi 446878488 397 FGASLGTSLFGVMVDKLGWygGFYLLMGGIVCCILFCYL 435
Cdd:cd17331 344 LVRTVSPTIGGALLQAYGF--PSFGLLGAAINGLLTVYL 380
|
|
| |
