|
Name |
Accession |
Description |
Interval |
E-value |
| PRK00481 |
PRK00481 |
NAD-dependent deacetylase; Provisional |
31-271 |
1.20e-135 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 234777 Cd Length: 242 Bit Score: 382.61 E-value: 1.20e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 31 DKVVPEAMEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQqpEIQPNAAH 110
Cdd:PRK00481 4 EELAEILDKAKRIVVLTGAGISAESGIPDFRSANGLWEEHRPEDVASPEGFARDPELVWKFYNERRRQLL--DAKPNAAH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 111 LALAKLQDaLGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLDWTGDVTPEDK-CHCCqfPAPLRPHVVW 189
Cdd:PRK00481 82 RALAELEK-LGKLVTVITQNIDGLHERAGSKNVIELHGSLLRARCTKCGQTYDLDEYLKPEPPrCPKC--GGILRPDVVL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 190 FGEMP--LGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVE 267
Cdd:PRK00481 159 FGEMLpeLAIDEAYEALEEADLFIVIGTSLVVYPAAGLPYEAREHGAKTVEINLEPTPLDSLFDLVIHGKAGEVVPELVE 238
|
....
gi 446875481 268 KLLK 271
Cdd:PRK00481 239 ELLA 242
|
|
| SIRT5_Af1_CobB |
cd01412 |
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human ... |
41-266 |
5.04e-123 |
|
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. CobB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase at an active site lysine to stimulate its enzymatic activity.
Pssm-ID: 238703 Cd Length: 224 Bit Score: 349.97 E-value: 5.04e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 41 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQPeiQPNAAHLALAKLQDAL 120
Cdd:cd01412 1 RRVVVLTGAGISAESGIPTFRDADGLWARFDPEELATPEAFARDPELVWEFYNWRRRKALRA--QPNPAHLALAELERRL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 121 GDrFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLDW--TGDVTPEDKCHCCqfPAPLRPHVVWFGEM-PLGM 197
Cdd:cd01412 79 PN-VLLITQNVDGLHERAGSRNVIELHGSLFRVRCSSCGYVGENneEIPEEELPRCPKC--GGLLRPGVVWFGESlPLAL 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446875481 198 DEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 266
Cdd:cd01412 156 LEAVEALAKADLFLVIGTSGVVYPAAGLPEEAKERGARVIEINPEPTPLSPIADFAFRGKAGEVLPALL 224
|
|
| SIR2 |
COG0846 |
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ... |
31-267 |
2.07e-118 |
|
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440607 Cd Length: 243 Bit Score: 339.06 E-value: 2.07e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 31 DKVVPEAMEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQqpEIQPNAAH 110
Cdd:COG0846 5 ERLAELLREAKRIVVLTGAGISAESGIPDFRGPDGLWEKYDPEEVASPEAFRRDPELVWAFYNERRRLLR--DAEPNAAH 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 111 LALAKLQDAlGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLDWTG-----DVTPEDKCHCCQfpAPLRP 185
Cdd:COG0846 83 RALAELEKA-GKLVFVITQNVDGLHQRAGSKNVIELHGSLHRLRCTKCGKRYDLEDvledlEGELPPRCPKCG--GLLRP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 186 HVVWFGEM--PLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVP 263
Cdd:COG0846 160 DVVWFGEMlpEEALERALEALAEADLFLVIGTSLVVYPAAGLPEYAKRAGAPLVEINPEPTPLDSLADLVIRGDAGEVLP 239
|
....
gi 446875481 264 EFVE 267
Cdd:COG0846 240 ALVE 243
|
|
| SIR2 |
pfam02146 |
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ... |
48-221 |
8.30e-83 |
|
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i
Pssm-ID: 426621 Cd Length: 179 Bit Score: 246.39 E-value: 8.30e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 48 GAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQA---FYNARRRQLQqPEIQPNAAHLALAKLQDAlGDRF 124
Cdd:pfam02146 1 GAGISTESGIPDFRSDDGLYAKLAPEELASPEAFFSNPELVWDpepFYNIARELLP-GEAQPNPAHYFIAKLEDK-GKLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 125 LLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLDW---TGDVTPEDKCHCCQFPAPLRPHVVWFGEM-PLGMDEI 200
Cdd:pfam02146 79 RLITQNIDGLHERAGSKKVVELHGSFAKARCVSCHQKYTGetlYERIRPEKVPHCPQCGGLLKPDIVFFGENlPDKFHRA 158
|
170 180
....*....|....*....|.
gi 446875481 201 YMALSMADIFIAIGTSGHVYP 221
Cdd:pfam02146 159 YEDLEEADLLIVIGTSLKVYP 179
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK00481 |
PRK00481 |
NAD-dependent deacetylase; Provisional |
31-271 |
1.20e-135 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 234777 Cd Length: 242 Bit Score: 382.61 E-value: 1.20e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 31 DKVVPEAMEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQqpEIQPNAAH 110
Cdd:PRK00481 4 EELAEILDKAKRIVVLTGAGISAESGIPDFRSANGLWEEHRPEDVASPEGFARDPELVWKFYNERRRQLL--DAKPNAAH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 111 LALAKLQDaLGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLDWTGDVTPEDK-CHCCqfPAPLRPHVVW 189
Cdd:PRK00481 82 RALAELEK-LGKLVTVITQNIDGLHERAGSKNVIELHGSLLRARCTKCGQTYDLDEYLKPEPPrCPKC--GGILRPDVVL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 190 FGEMP--LGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVE 267
Cdd:PRK00481 159 FGEMLpeLAIDEAYEALEEADLFIVIGTSLVVYPAAGLPYEAREHGAKTVEINLEPTPLDSLFDLVIHGKAGEVVPELVE 238
|
....
gi 446875481 268 KLLK 271
Cdd:PRK00481 239 ELLA 242
|
|
| SIRT5_Af1_CobB |
cd01412 |
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human ... |
41-266 |
5.04e-123 |
|
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. CobB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase at an active site lysine to stimulate its enzymatic activity.
Pssm-ID: 238703 Cd Length: 224 Bit Score: 349.97 E-value: 5.04e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 41 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQPeiQPNAAHLALAKLQDAL 120
Cdd:cd01412 1 RRVVVLTGAGISAESGIPTFRDADGLWARFDPEELATPEAFARDPELVWEFYNWRRRKALRA--QPNPAHLALAELERRL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 121 GDrFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLDW--TGDVTPEDKCHCCqfPAPLRPHVVWFGEM-PLGM 197
Cdd:cd01412 79 PN-VLLITQNVDGLHERAGSRNVIELHGSLFRVRCSSCGYVGENneEIPEEELPRCPKC--GGLLRPGVVWFGESlPLAL 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446875481 198 DEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 266
Cdd:cd01412 156 LEAVEALAKADLFLVIGTSGVVYPAAGLPEEAKERGARVIEINPEPTPLSPIADFAFRGKAGEVLPALL 224
|
|
| SIR2 |
COG0846 |
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ... |
31-267 |
2.07e-118 |
|
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440607 Cd Length: 243 Bit Score: 339.06 E-value: 2.07e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 31 DKVVPEAMEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQqpEIQPNAAH 110
Cdd:COG0846 5 ERLAELLREAKRIVVLTGAGISAESGIPDFRGPDGLWEKYDPEEVASPEAFRRDPELVWAFYNERRRLLR--DAEPNAAH 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 111 LALAKLQDAlGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLDWTG-----DVTPEDKCHCCQfpAPLRP 185
Cdd:COG0846 83 RALAELEKA-GKLVFVITQNVDGLHQRAGSKNVIELHGSLHRLRCTKCGKRYDLEDvledlEGELPPRCPKCG--GLLRP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 186 HVVWFGEM--PLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVP 263
Cdd:COG0846 160 DVVWFGEMlpEEALERALEALAEADLFLVIGTSLVVYPAAGLPEYAKRAGAPLVEINPEPTPLDSLADLVIRGDAGEVLP 239
|
....
gi 446875481 264 EFVE 267
Cdd:COG0846 240 ALVE 243
|
|
| PTZ00408 |
PTZ00408 |
NAD-dependent deacetylase; Provisional |
42-272 |
1.21e-117 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 240405 Cd Length: 242 Bit Score: 337.18 E-value: 1.21e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 42 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQPEIQPNAAHLALAKLQDAL- 120
Cdd:PTZ00408 6 CITILTGAGISAESGISTFRDGNGLWENHRVEDVATPDAFLRNPALVQRFYNERRRALLSSSVKPNKAHFALAKLEREYr 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 121 GDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLDWTGDVT-PEDKCHCCQFPAPLRPHVVWFGEMPLGMDE 199
Cdd:PTZ00408 86 GGKVVVVTQNVDNLHERAGSTHVLHMHGELLKVRCTATGHVFDWTEDVVhGSSRCKCCGCVGTLRPHIVWFGEMPLYMDE 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446875481 200 IYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKG 272
Cdd:PTZ00408 166 IESVMSKTDLFVAVGTSGNVYPAAGFVGRAQFYGATTLELNLEEGTNYSQFDESIYGKASVIVPAWVDRVLKL 238
|
|
| SIR2-fam |
cd01407 |
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze ... |
42-257 |
1.35e-93 |
|
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer.
Pssm-ID: 238698 Cd Length: 218 Bit Score: 275.22 E-value: 1.35e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 42 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVA-TPEGFDRDPELVQAFYNARRRQLQqpeIQPNAAHLALAKLQDAl 120
Cdd:cd01407 2 RIVVLTGAGISTESGIPDFRSPGGLWARLDPEELAfSPEAFRRDPELFWGFYRERRYPLN---AQPNPAHRALAELERK- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 121 GDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLDWTGDVTPED-----KCHCCQfpAPLRPHVVWFGEM-P 194
Cdd:cd01407 78 GKLKRVITQNVDGLHQRAGSPKVIELHGSLFRVRCTKCGKEYPRDELQADIDreevpRCPKCG--GLLRPDVVFFGESlP 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446875481 195 LGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGP 257
Cdd:cd01407 156 EELDEAAEALAKADLLLVIGTSLQVYPAAGLPLYAPERGAPVVIINLEPTPADRKADLVILGD 218
|
|
| SIR2 |
pfam02146 |
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ... |
48-221 |
8.30e-83 |
|
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i
Pssm-ID: 426621 Cd Length: 179 Bit Score: 246.39 E-value: 8.30e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 48 GAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQA---FYNARRRQLQqPEIQPNAAHLALAKLQDAlGDRF 124
Cdd:pfam02146 1 GAGISTESGIPDFRSDDGLYAKLAPEELASPEAFFSNPELVWDpepFYNIARELLP-GEAQPNPAHYFIAKLEDK-GKLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 125 LLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLDW---TGDVTPEDKCHCCQFPAPLRPHVVWFGEM-PLGMDEI 200
Cdd:pfam02146 79 RLITQNIDGLHERAGSKKVVELHGSFAKARCVSCHQKYTGetlYERIRPEKVPHCPQCGGLLKPDIVFFGENlPDKFHRA 158
|
170 180
....*....|....*....|.
gi 446875481 201 YMALSMADIFIAIGTSGHVYP 221
Cdd:pfam02146 159 YEDLEEADLLIVIGTSLKVYP 179
|
|
| SIR2 |
cd00296 |
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which ... |
42-243 |
3.61e-78 |
|
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer. Also included in this superfamily is a group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines.
Pssm-ID: 238184 [Multi-domain] Cd Length: 222 Bit Score: 236.09 E-value: 3.61e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 42 RVLVLTGAGISAESGIRTFR-AADGLWEEHRVEDVA-TPEGFDRDPELVQAFYNARRRQLqqPEIQPNAAHLALAKLQDA 119
Cdd:cd00296 2 RVVVFTGAGISTESGIPDFRgLGTGLWTRLDPEELAfSPEAFRRDPELFWLFYKERRYTP--LDAKPNPAHRALAELERK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 120 lGDRFLLVTQNIDNLHERAGN--TNVIHMHGELLKVRCSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL-- 195
Cdd:cd00296 80 -GKLKRIITQNVDGLHERAGSrrNRVIELHGSLDRVRCTSCGKEYPRDEVLEREKPPRCPKCGGLLRPDVVDFGEALPke 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 446875481 196 GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP 243
Cdd:cd00296 159 WFDRALEALLEADLVLVIGTSLTVYPAARLLLRAPERGAPVVIINREP 206
|
|
| SIR2_Af2 |
cd01413 |
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, ... |
42-245 |
1.35e-53 |
|
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The Sir2 homolog from the archaea Sulfolobus solftaricus deacetylates the non-specific DNA protein Alba to mediate transcription repression.
Pssm-ID: 238704 Cd Length: 222 Bit Score: 173.32 E-value: 1.35e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 42 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQqpEIQPNAAHLALAKLQdALG 121
Cdd:cd01413 6 KTVVLTGAGISTESGIPDFRSPDGLWKKYDPEEVASIDYFYRNPEEFWRFYKEIILGLL--EAQPNKAHYFLAELE-KQG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 122 DRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLDW--TGDVTPEDKCHCCQFPAPLRPHVVWFGEM-PLG-M 197
Cdd:cd01413 83 IIKAIITQNIDGLHQRAGSKNVIELHGTLQTAYCVNCGSKYDLeeVKYAKKHEVPRCPKCGGIIRPDVVLFGEPlPQAlL 162
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 446875481 198 DEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ 245
Cdd:cd01413 163 REAIEAAKEADLFIVLGSSLVVYPANLLPLIAKENGAKLVIVNADETP 210
|
|
| SIR2H |
cd01411 |
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species ... |
42-266 |
7.07e-41 |
|
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238702 Cd Length: 225 Bit Score: 140.96 E-value: 7.07e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 42 RVLVLTGAGISAESGIRTFRAADGLWEE---HRVEDVATPEGFDRDPElvqAFYNARRRQLQQPEIQPNAAHLALAKLQD 118
Cdd:cd01411 10 RIVFFTGAGVSTASGIPDYRSKNGLYNEiykYSPEYLLSHDFLEREPE---KFYQFVKENLYFPDAKPNIIHQKMAELEK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 119 AlgDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLDWTGDVTPE--DKCHccqfpAPLRPHVVWFGEMPLG 196
Cdd:cd01411 87 M--GLKAVITQNIDGLHQKAGSKNVVEFHGSLYRIYCTVCGKTVDWEEYLKSPyhAKCG-----GVIRPDIVLYEEMLNE 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446875481 197 M--DEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKlHGAHTVELNLEPSQvgnefaekYYGPASQVVPEFV 266
Cdd:cd01411 160 SviEEAIQAIEKADLLVIVGTSFVVYPFAGLIDYRQ-AGANLIAINKEPTQ--------LDSPATLVIKDAV 222
|
|
| PTZ00409 |
PTZ00409 |
Sir2 (Silent Information Regulator) protein; Provisional |
43-272 |
3.35e-37 |
|
Sir2 (Silent Information Regulator) protein; Provisional
Pssm-ID: 173599 [Multi-domain] Cd Length: 271 Bit Score: 132.74 E-value: 3.35e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 43 VLVLTGAGISAESGIRTFR-AADGLWEEHRVEDVATPEGFDRDPELVqafYNARRRQLQQPEIQPNAAHLALAKLQdALG 121
Cdd:PTZ00409 31 VVALTGSGTSAESNIPSFRgPSSSIWSKYDPKIYGTIWGFWKYPEKI---WEVIRDISSDYEIELNPGHVALSTLE-SLG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 122 DRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL-----------DWTGDVTPEdkCHCCQFpapLRPHVVWF 190
Cdd:PTZ00409 107 YLKFVVTQNVDGLHEESGNTKVIPLHGSVFEARCCTCRKTIqlnkimlqktsHFMHQLPPE--CPCGGI---FKPNVILF 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 191 GE-MPLG-MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY-GPASQVVPefVE 267
Cdd:PTZ00409 182 GEvIPKSlLKQAEKEIDKCDLLLVVGTSSSVSTATNLCYRAHRKKKKIVEVNISKTYITNRISDYHVrAKFSELAQ--IS 259
|
....*
gi 446875481 268 KLLKG 272
Cdd:PTZ00409 260 DILKG 264
|
|
| SIRT7 |
cd01410 |
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, ... |
41-245 |
1.12e-34 |
|
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238701 Cd Length: 206 Bit Score: 124.34 E-value: 1.12e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 41 PRVLVLTGAGISAESGIRTFRAADGLWEEHRvedvatPEGFDRDpelvqafYNARRRqlqqpEIQPNAAHLALAKLQDAl 120
Cdd:cd01410 1 KHLVVFTGAGISTSAGIPDFRGPNGVWTLLP------EDKGRRR-------FSWRFR-----RAEPTLTHMALVELERA- 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 121 GDRFLLVTQNIDNLHERAGN--TNVIHMHGELLKVRCSQSGQ------VLDWTGDVTPEDKCHCCQfpAPLRPHVVWFGE 192
Cdd:cd01410 62 GLLKFVISQNVDGLHLRSGLprEKLSELHGNMFIEVCKSCGPeyvrddVVETRGDKETGRRCHACG--GILKDTIVDFGE 139
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 446875481 193 -MPLG-MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ 245
Cdd:cd01410 140 rLPPEnWMGAAAAACRADLFLCLGTSLQVTPAANLPLKAARAGGRLVIVNLQPTP 194
|
|
| SIRT4 |
cd01409 |
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and ... |
39-243 |
1.18e-30 |
|
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238700 Cd Length: 260 Bit Score: 115.09 E-value: 1.18e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 39 EKPRVLVLTGAGISAESGIRTFRAADGLWeeHRVEDVATPEGFDRDPelvqafyNARRR-----QLQQPEI---QPNAAH 110
Cdd:cd01409 7 RSRRLLVLTGAGISTESGIPDYRSEGGLY--SRTFRPMTHQEFMRSP-------AARQRywarsFVGWPRFsaaQPNAAH 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 111 LALAKLQDAlGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLDWT-----------------------GD 167
Cdd:cd01409 78 RALAALEAA-GRLHGLITQNVDGLHTKAGSRNVVELHGSLHRVVCLSCGFRTPRAelqdrlealnpgfaeqaagqapdGD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 168 VTPEDK---------CHCCQfpAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHT 236
Cdd:cd01409 157 VDLEDEqvagfrvpeCERCG--GVLKPDVVFFGENvpRDRVVTAAARLAEADALLVLGSSLMVYSGYRFVLAAAEAGLPI 234
|
....*..
gi 446875481 237 VELNLEP 243
Cdd:cd01409 235 AIVNIGP 241
|
|
| PRK05333 |
PRK05333 |
NAD-dependent protein deacetylase; |
41-241 |
5.57e-28 |
|
NAD-dependent protein deacetylase;
Pssm-ID: 235415 Cd Length: 285 Bit Score: 108.61 E-value: 5.57e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 41 PRVLVLTGAGISAESGIRTFRAADGLWEEhrvedvaTPegfdrdPELVQAFYN---ARRRQLQQPEI--------QPNAA 109
Cdd:PRK05333 20 PRLFVLTGAGISTDSGIPDYRDRNGQWKR-------SP------PITYQAFMGsdaARRRYWARSMVgwpvfgraQPNAA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 110 HLALAKLQDAlGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL------DWTGDVTPE------------ 171
Cdd:PRK05333 87 HHALARLGAA-GRIERLVTQNVDGLHQRAGSRDVIELHGRLDGVRCMGCGARHpraeiqHVLEAANPEwlaleaapapdg 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 172 ----DKCHCCQFPAP--------LRPHVVWFGE-MPLG-MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTV 237
Cdd:PRK05333 166 dadlEWAAFDHFRVPacpacggiLKPDVVFFGEnVPRErVAAARAALDAADAVLVVGSSLMVYSGYRFCVWAAQQGKPIA 245
|
....
gi 446875481 238 ELNL 241
Cdd:PRK05333 246 ALNL 249
|
|
| PRK14138 |
PRK14138 |
NAD-dependent deacetylase; Provisional |
45-241 |
7.94e-28 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 172627 [Multi-domain] Cd Length: 244 Bit Score: 107.22 E-value: 7.94e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 45 VLTGAGISAESGIRTFRAADGLWEEHRvEDVATPEGFDRDPElvqAFYN-ARRRQLQQPEIQPNAAHLALAKLQDAlGDR 123
Cdd:PRK14138 16 TLTGAGISTPSGIPDFRGPQGIYKKYP-QNVFDIDFFYSHPE---EFYRfAKEGIFPMLEAKPNLAHVLLAKLEEK-GLI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 124 FLLVTQNIDNLHERAGNTNVIHMHGELLK---VRCSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPL-GMD 198
Cdd:PRK14138 91 EAVITQNIDRLHQKAGSKKVIELHGNVEEyycVRCGKRYTVEDVIEKLEKSDVPRCDDCSGLIRPNIVFFGEaLPQdALR 170
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 446875481 199 EIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNL 241
Cdd:PRK14138 171 EAIRLSSKASLMIVMGSSLVVYPAAELPLITVRSGGKLVIVNL 213
|
|
| SIRT1 |
cd01408 |
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and ... |
42-243 |
1.46e-17 |
|
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The nuclear SIRT1 has been shown to target the p53 tumor suppressor protein for deacetylation to suppress DNA damage, and the cytoplasmic SIRT2 homolog has been shown to target alpha-tubulin for deacetylation for the maintenance of cell integrity.
Pssm-ID: 238699 Cd Length: 235 Bit Score: 79.60 E-value: 1.46e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 42 RVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG------FDRDPElvqAFYNArRRQLQQPEIQPNAAHLALA 114
Cdd:cd01408 2 KIVVLVGAGISTSAGIPDFRSPGtGLYANLARYNLPYPEAmfdisyFRKNPR---PFYAL-AKELYPGQFKPSVAHYFIK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 115 KLQDAlGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKVRCSQSGQVLDwtGDVTPED-------KCHCCQfpAPLRP 185
Cdd:cd01408 78 LLEDK-GLLLRNYTQNIDTLERVAGvpDDRIIEAHGSFATAHCIKCKHKYP--GDWMREDifnqevpKCPRCG--GLVKP 152
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 186 HVVWFGE-MPLGMDEIYMALSM-ADIFIAIGTSGHVYPAAGFVHEAKLHgAHTVELNLEP 243
Cdd:cd01408 153 DIVFFGEsLPSRFFSHMEEDKEeADLLIVIGTSLKVAPFASLPSRVPSE-VPRVLINREP 211
|
|
| PTZ00410 |
PTZ00410 |
NAD-dependent SIR2; Provisional |
42-223 |
2.90e-10 |
|
NAD-dependent SIR2; Provisional
Pssm-ID: 185600 Cd Length: 349 Bit Score: 59.88 E-value: 2.90e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 42 RVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQ---AFYN-ARRRQLQQPEIQPNAAHLALAKL 116
Cdd:PTZ00410 31 KILVMVGAGISVAAGIPDFRSPHtGIYAKLGKYNLNSPTDAFSLTLLREkpeVFYSiAREMDLWPGHFQPTAVHHFIRLL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 117 QDAlGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKVRCSQSGQVLD--------WTGDVTpedkcHCCQFPAPLRPH 186
Cdd:PTZ00410 111 ADE-GRLLRCCTQNIDGLERAAGvpPSLLVEAHGSFSAASCIECHTPYDieqayleaRSGKVP-----HCSTCGGIVKPD 184
|
170 180 190
....*....|....*....|....*....|....*...
gi 446875481 187 VVWFGE-MPLGMDEIYMALSMADIFIAIGTSGHVYPAA 223
Cdd:PTZ00410 185 VVFFGEnLPDAFFNVHHDIPEAELLLIIGTSLQVHPFA 222
|
|
| SIR2-like |
cd01406 |
Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key ... |
42-148 |
1.27e-05 |
|
Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation.
Pssm-ID: 238697 [Multi-domain] Cd Length: 242 Bit Score: 45.47 E-value: 1.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446875481 42 RVLVLTGAGISAESGIRTFRA-ADGLWEEHRVEDVA---TPEGFDRDPELVQAFY----------NARRRQLQQPEIQPN 107
Cdd:cd01406 2 RVVIFVGAGVSVSSGLPDWKTlLDEIASELGLEIDGysvEAKDENDYLELAELLEkefgtigikiNAVLEEKTRPDFEPS 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446875481 108 AAHLALAKLQDALGDRFLLVTQNIDNLHERA----------------------GNTNVIHMHG 148
Cdd:cd01406 82 PLHELLLRLFINNEGDVIIITTNYDRLLETAlkeinkvvkvivsvqlalsasaRFNGVYKIHG 144
|
|
| |
