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Conserved domains on  [gi|446850232|ref|WP_000927488|]
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MULTISPECIES: methylated-DNA--[protein]-cysteine S-methyltransferase [Acinetobacter calcoaceticus/baumannii complex]

Protein Classification

methylated-DNA--[protein]-cysteine S-methyltransferase( domain architecture ID 11417447)

methylated-DNA--[protein]-cysteine S-methyltransferase is involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA; it repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme

CATH:  3.30.160.70|1.10.10.10
EC:  2.1.1.63
Gene Ontology:  GO:0003908|GO:0003677|GO:0046872|GO:0006281|GO:0032259
PubMed:  17500045|17485252
SCOP:  4000565|4000678

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AdaB COG0350
DNA repair enzyme Ada (O6-methylguanine-DNA--protein-cysteine methyltransferase) [Replication, ...
 3-159 1.45e-76

DNA repair enzyme Ada (O6-methylguanine-DNA--protein-cysteine methyltransferase) [Replication, recombination and repair];


:

Pssm-ID: 440119 [Multi-domain]  Cd Length: 163  Bit Score: 225.14  E-value: 1.45e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850232   3 LSYKYINSPVGQLKLVANENALVAVLWDNENPKR-VRLAELVEQTEHPILLKTEQQLAEYFEGKRREFTLPLDFEGTAFQ 81
Cdd:COG0350    2 IRYAIFDTPLGPLLIAATDRGLCALSFGDDREEAlLARFPAALREDPPLLAEAARQLDAYFAGERKDFDLPLDLRGTPFQ 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446850232  82 KQVWTALLTIPYGETRSYKDIAVQIGNEKAVRAVGAANGKNPISIIAPCHRVIGAGGALVGFAGGLDKKDILLRLEQK 159
Cdd:COG0350   82 RRVWEALRKIPYGETVTYGELARAIGRPKAARAVGSACGANPIPIIIPCHRVIGADGSLGGYAGGLERKRALLELEGA 159
 
Name Accession Description Interval E-value
AdaB COG0350
DNA repair enzyme Ada (O6-methylguanine-DNA--protein-cysteine methyltransferase) [Replication, ...
 3-159 1.45e-76

DNA repair enzyme Ada (O6-methylguanine-DNA--protein-cysteine methyltransferase) [Replication, recombination and repair];


Pssm-ID: 440119 [Multi-domain]  Cd Length: 163  Bit Score: 225.14  E-value: 1.45e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850232   3 LSYKYINSPVGQLKLVANENALVAVLWDNENPKR-VRLAELVEQTEHPILLKTEQQLAEYFEGKRREFTLPLDFEGTAFQ 81
Cdd:COG0350    2 IRYAIFDTPLGPLLIAATDRGLCALSFGDDREEAlLARFPAALREDPPLLAEAARQLDAYFAGERKDFDLPLDLRGTPFQ 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446850232  82 KQVWTALLTIPYGETRSYKDIAVQIGNEKAVRAVGAANGKNPISIIAPCHRVIGAGGALVGFAGGLDKKDILLRLEQK 159
Cdd:COG0350   82 RRVWEALRKIPYGETVTYGELARAIGRPKAARAVGSACGANPIPIIIPCHRVIGADGSLGGYAGGLERKRALLELEGA 159
PRK00901 PRK00901
methylated-DNA--protein-cysteine methyltransferase; Provisional
 4-157 1.49e-64

methylated-DNA--protein-cysteine methyltransferase; Provisional


Pssm-ID: 234860 [Multi-domain]  Cd Length: 155  Bit Score: 194.50  E-value: 1.49e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850232   4 SYKYINSPVGQLKLVANENALVAVLWDNENpkrvrLAELVEQTEHPILLKTEQQLAEYFEGKRREFTLPLDFEGTAFQKQ 83
Cdd:PRK00901   3 NIYFYETPIGKIGIAENGTAITHLCFGEDK-----IPKDVTILETDLLKEANKQLEEYFEGKRKKFDLPLAPQGTEFQKK 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446850232  84 VWTALLTIPYGETRSYKDIAVQIGNEKAVRAVGAANGKNPISIIAPCHRVIGAGGALVGFAGGLDKKDILLRLE 157
Cdd:PRK00901  78 VWKALQEIPYGETRSYKEIAVNIGNPKACRAVGLANNKNPIPIFIPCHRVIGANGKLVGYAGGLDIKEKLLKLE 151
DNA_binding_1 pfam01035
6-O-methylguanine DNA methyltransferase, DNA binding domain; This is the C-terminal ...
 79-158 3.77e-43

6-O-methylguanine DNA methyltransferase, DNA binding domain; This is the C-terminal DNA-binding domain of 6-O-methylguanine-DNA methyltransferases.


Pssm-ID: 460036  Cd Length: 81  Bit Score: 137.49  E-value: 3.77e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850232   79 AFQKQVWTALLTIPYGETRSYKDIAVQIGNEKAVRAVGAANGKNPISIIAPCHRVIGAGGALVGFAGGLDKKDILLRLEQ 158
Cdd:pfam01035   1 PFQRRVWEALRQIPYGKTTTYGEIAKLLGRPKAARAVGNALGANPIPIIVPCHRVVGSDGSLGGYAGGLERKRALLELEG 80
ogt TIGR00589
O-6-methylguanine DNA methyltransferase; All proteins in this family for which functions are ...
 78-157 3.68e-41

O-6-methylguanine DNA methyltransferase; All proteins in this family for which functions are known are involved alkyl-DNA transferases which remove alkyl groups from DNA as part of alkylation DNA repair. Some of the proteins in this family are also transcription regulators and have a distinct transcription regulatory domain. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273157  Cd Length: 80  Bit Score: 132.44  E-value: 3.68e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850232   78 TAFQKQVWTALLTIPYGETRSYKDIAVQIGNEKAVRAVGAANGKNPISIIAPCHRVIGAGGALVGFAGGLDKKDILLRLE 157
Cdd:TIGR00589   1 TPFQQKVWKALRTIPYGETKSYGQLAKAIGNPKAARAVGGANGRNPLAILVPCHRVVGKNGTLTGYGGGLERKEFLLEHE 80
ATase cd06445
The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT ...
 80-158 4.82e-39

The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases are specific for repair of guanines with O6-alkyl adducts, however human ATase is not limited to O6-methylguanine, repairing many other adducts at the O6-position of guanine as well. ATase is widely distributed among species. Most ATases have N- and C-terminal domains. The C-terminal domain contains the conserved active-site cysteine motif (PCHR), the O6-alkylguanine binding channel, and the helix-turn-helix (HTH) DNA-binding motif. The active site is located near the recognition helix of the HTH motif. While the C-terminal domain of ATase contains residues that are necessary for DNA binding and alkyl transfer, the function of the N-terminal domain is still unknown. Removal of the N-terminal domain abolishes the activity of the C-terminal domain, suggesting an important structural role for the N-terminal domain in orienting the C-terminal domain for proper catalysis. Some ATase C-terminal domain homologs are either single-domain proteins that lack an N-terminal domain, or have a tryptophan substituted in place of the acceptor cysteine (i.e. the motif PCHR is replaced by PWHR). ATase null mutant mice are viable, fertile, and have a normal lifespan.


Pssm-ID: 119438 [Multi-domain]  Cd Length: 79  Bit Score: 127.21  E-value: 4.82e-39
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446850232  80 FQKQVWTALLTIPYGETRSYKDIAVQIGNEKAVRAVGAANGKNPISIIAPCHRVIGAGGALVGFAGGLDKKDILLRLEQ 158
Cdd:cd06445    1 FQRRVWEALRQIPYGEVTTYGQIAKLAGTPKAARAVGSALARNPIPILIPCHRVVRSDGGLGGYRGGLERKRELLELEG 79
 
Name Accession Description Interval E-value
AdaB COG0350
DNA repair enzyme Ada (O6-methylguanine-DNA--protein-cysteine methyltransferase) [Replication, ...
 3-159 1.45e-76

DNA repair enzyme Ada (O6-methylguanine-DNA--protein-cysteine methyltransferase) [Replication, recombination and repair];


Pssm-ID: 440119 [Multi-domain]  Cd Length: 163  Bit Score: 225.14  E-value: 1.45e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850232   3 LSYKYINSPVGQLKLVANENALVAVLWDNENPKR-VRLAELVEQTEHPILLKTEQQLAEYFEGKRREFTLPLDFEGTAFQ 81
Cdd:COG0350    2 IRYAIFDTPLGPLLIAATDRGLCALSFGDDREEAlLARFPAALREDPPLLAEAARQLDAYFAGERKDFDLPLDLRGTPFQ 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446850232  82 KQVWTALLTIPYGETRSYKDIAVQIGNEKAVRAVGAANGKNPISIIAPCHRVIGAGGALVGFAGGLDKKDILLRLEQK 159
Cdd:COG0350   82 RRVWEALRKIPYGETVTYGELARAIGRPKAARAVGSACGANPIPIIIPCHRVIGADGSLGGYAGGLERKRALLELEGA 159
PRK00901 PRK00901
methylated-DNA--protein-cysteine methyltransferase; Provisional
 4-157 1.49e-64

methylated-DNA--protein-cysteine methyltransferase; Provisional


Pssm-ID: 234860 [Multi-domain]  Cd Length: 155  Bit Score: 194.50  E-value: 1.49e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850232   4 SYKYINSPVGQLKLVANENALVAVLWDNENpkrvrLAELVEQTEHPILLKTEQQLAEYFEGKRREFTLPLDFEGTAFQKQ 83
Cdd:PRK00901   3 NIYFYETPIGKIGIAENGTAITHLCFGEDK-----IPKDVTILETDLLKEANKQLEEYFEGKRKKFDLPLAPQGTEFQKK 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446850232  84 VWTALLTIPYGETRSYKDIAVQIGNEKAVRAVGAANGKNPISIIAPCHRVIGAGGALVGFAGGLDKKDILLRLE 157
Cdd:PRK00901  78 VWKALQEIPYGETRSYKEIAVNIGNPKACRAVGLANNKNPIPIFIPCHRVIGANGKLVGYAGGLDIKEKLLKLE 151
DNA_binding_1 pfam01035
6-O-methylguanine DNA methyltransferase, DNA binding domain; This is the C-terminal ...
 79-158 3.77e-43

6-O-methylguanine DNA methyltransferase, DNA binding domain; This is the C-terminal DNA-binding domain of 6-O-methylguanine-DNA methyltransferases.


Pssm-ID: 460036  Cd Length: 81  Bit Score: 137.49  E-value: 3.77e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850232   79 AFQKQVWTALLTIPYGETRSYKDIAVQIGNEKAVRAVGAANGKNPISIIAPCHRVIGAGGALVGFAGGLDKKDILLRLEQ 158
Cdd:pfam01035   1 PFQRRVWEALRQIPYGKTTTYGEIAKLLGRPKAARAVGNALGANPIPIIVPCHRVVGSDGSLGGYAGGLERKRALLELEG 80
ogt TIGR00589
O-6-methylguanine DNA methyltransferase; All proteins in this family for which functions are ...
 78-157 3.68e-41

O-6-methylguanine DNA methyltransferase; All proteins in this family for which functions are known are involved alkyl-DNA transferases which remove alkyl groups from DNA as part of alkylation DNA repair. Some of the proteins in this family are also transcription regulators and have a distinct transcription regulatory domain. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273157  Cd Length: 80  Bit Score: 132.44  E-value: 3.68e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850232   78 TAFQKQVWTALLTIPYGETRSYKDIAVQIGNEKAVRAVGAANGKNPISIIAPCHRVIGAGGALVGFAGGLDKKDILLRLE 157
Cdd:TIGR00589   1 TPFQQKVWKALRTIPYGETKSYGQLAKAIGNPKAARAVGGANGRNPLAILVPCHRVVGKNGTLTGYGGGLERKEFLLEHE 80
ATase cd06445
The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT ...
 80-158 4.82e-39

The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases are specific for repair of guanines with O6-alkyl adducts, however human ATase is not limited to O6-methylguanine, repairing many other adducts at the O6-position of guanine as well. ATase is widely distributed among species. Most ATases have N- and C-terminal domains. The C-terminal domain contains the conserved active-site cysteine motif (PCHR), the O6-alkylguanine binding channel, and the helix-turn-helix (HTH) DNA-binding motif. The active site is located near the recognition helix of the HTH motif. While the C-terminal domain of ATase contains residues that are necessary for DNA binding and alkyl transfer, the function of the N-terminal domain is still unknown. Removal of the N-terminal domain abolishes the activity of the C-terminal domain, suggesting an important structural role for the N-terminal domain in orienting the C-terminal domain for proper catalysis. Some ATase C-terminal domain homologs are either single-domain proteins that lack an N-terminal domain, or have a tryptophan substituted in place of the acceptor cysteine (i.e. the motif PCHR is replaced by PWHR). ATase null mutant mice are viable, fertile, and have a normal lifespan.


Pssm-ID: 119438 [Multi-domain]  Cd Length: 79  Bit Score: 127.21  E-value: 4.82e-39
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446850232  80 FQKQVWTALLTIPYGETRSYKDIAVQIGNEKAVRAVGAANGKNPISIIAPCHRVIGAGGALVGFAGGLDKKDILLRLEQ 158
Cdd:cd06445    1 FQRRVWEALRQIPYGEVTTYGQIAKLAGTPKAARAVGSALARNPIPILIPCHRVVRSDGGLGGYRGGLERKRELLELEG 79
PRK10286 PRK10286
methylated-DNA--[protein]-cysteine S-methyltransferase;
8-157 5.91e-37

methylated-DNA--[protein]-cysteine S-methyltransferase;


Pssm-ID: 182355 [Multi-domain]  Cd Length: 171  Bit Score: 124.98  E-value: 5.91e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850232   8 INSPVGQLKLVANEN-ALVAVLWDNENPKRVRLAELVEQTEHPILLKT------EQQLAEYFEGKRREF-TLPLDFEGTA 79
Cdd:PRK10286   9 IATPLGPLWVICDEQfRLRAVEWEEYSERMVQLLDIHYRKEGYERISAtnpgglSDKLRDYFAGNLSIIdTLPTATGGTP 88

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446850232  80 FQKQVWTALLTIPYGETRSYKDIAVQIGNEKAVRAVGAANGKNPISIIAPCHRVIGAGGALVGFAGGLDKKDILLRLE 157
Cdd:PRK10286  89 FQREVWQTLRTIPCGQVMHYGQLAEQLGRPGAARAVGAANGSNPISIVVPCHRVIGRNGTMTGYAGGVQRKEWLLRHE 166
PRK15435 PRK15435
bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;
17-157 1.32e-34

bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;


Pssm-ID: 185333 [Multi-domain]  Cd Length: 353  Bit Score: 123.75  E-value: 1.32e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850232  17 LVA-NENALVAVLW-DNENPKRVRLAELVEQTEH-PILLKTEQQLAEYF---EGKRREFTLPLDFEGTAFQKQVWTALLT 90
Cdd:PRK15435 202 LVAeSERGICAILLgDDDAALISELQQMFPAADNaPADLTFQQHVREVIaslNQRDTPLTLPLDIRGTAFQQQVWQALRT 281

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446850232  91 IPYGETRSYKDIAVQIGNEKAVRAVGAANGKNPISIIAPCHRVIGAGGALVGFAGGLDKKDILLRLE 157
Cdd:PRK15435 282 IPCGETVSYQQLANAIGKPKAVRAVASACAANKLAIVIPCHRVVRGDGALSGYRWGVSRKAQLLRRE 348
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 34-157 5.36e-30

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 111.68  E-value: 5.36e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850232  34 PKRVRLAELVEQTEHPILLktEQQLAEYFEGKRREFTLPLDFEGTAFQKQVWTALLTIPYGETRSYKDIAVQIGNEKAVR 113
Cdd:COG2169  228 QDRFPAAELIGGDAAFEQL--VAEVVGFVEGPLLGLDLPLDLRGTAFQQRVWQALRAIPAGETASYAEIAARIGAPKAVR 305

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 446850232 114 AVGAANGKNPISIIAPCHRVIGAGGALVGFAGGLDKKDILLRLE 157
Cdd:COG2169  306 AVAAACAANQLAVAIPCHRVVRADGALSGYRWGVERKRALLERE 349
Atl1 COG3695
Alkylated DNA nucleotide flippase Atl1, participates in nucleotide excision repair, Ada-like ...
 80-157 6.22e-11

Alkylated DNA nucleotide flippase Atl1, participates in nucleotide excision repair, Ada-like DNA-binding domain [Transcription];


Pssm-ID: 442910  Cd Length: 104  Bit Score: 55.96  E-value: 6.22e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446850232  80 FQKQVWTALLTIPYGETRSYKDIAVQIGNEKAVRAVGAANGKNPISIIAPCHRVIGAGGAL-VGFAGGLDKKDILLRLE 157
Cdd:COG3695    6 FYERVYEVVAQIPPGRVATYGDIAALAGLPRGARQVGRALRALPEGSDLPWHRVVNADGRLsPGHAGGAEEQRELLEAE 84
Methyltransf_1N pfam02870
6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; This entry represents the ...
 2-75 2.41e-09

6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; This entry represents the N-terminal ribonuclease-like domain associated with 6-O-methylguanine DNA methyltransferase activity. The repair of DNA containing O6-alkylated guanine is carried out by DNA-[protein]-cysteine S-methyltransferase (also known as O-6-methylguanine-DNA-alkyltransferase)


Pssm-ID: 397139 [Multi-domain]  Cd Length: 77  Bit Score: 51.21  E-value: 2.41e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446850232    2 LLSYKYINSPVGQLKLVANENALVAVLWDNEN-PKRVRLAELVEQTEH-PILLKTEQQLAEYFEGKR-REFTLPLDF 75
Cdd:pfam02870   1 ALYYTLIDSPLGRLLLAGDERGLTAIDFLDKDyALRKELPKVLPQPELlPALALLVQALEEYFAGELkPEFTLPLDQ 77
PRK03887 PRK03887
methylated-DNA--protein-cysteine methyltransferase; Provisional
 73-157 7.66e-08

methylated-DNA--protein-cysteine methyltransferase; Provisional


Pssm-ID: 167628 [Multi-domain]  Cd Length: 175  Bit Score: 49.35  E-value: 7.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850232  73 LDFEG-TAFQKQVWTALL-TIPYGETRSYKDIAVQIGNekAVRAVGAANGKNPISIIAPCHRVIGAGGALVgFAGGLDKK 150
Cdd:PRK03887  85 LSFEGlTPFERKVYEWLTkNVKRGEVITYGELAKALNT--SPRAVGGAMKRNPYPIIVPCHRVVGRKNPGL-YTPKPEYK 161


                 ....*..
gi 446850232 151 DILLRLE 157
Cdd:PRK03887 162 KFLLEVE 168
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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