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Conserved domains on  [gi|446844696|ref|WP_000921952|]
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MULTISPECIES: plasmid segregation protein ParM [Enterobacteriaceae]

Protein Classification

plasmid segregation protein ParM( domain architecture ID 11162670)

plasmid segregation protein ParM is involved in the control of plasmid partition, and is required for the accurate segregation of the plasmid

CATH:  3.30.420.40
Gene Ontology:  GO:0030541|GO:0000166
PubMed:  8800467|7781919|17158703|12727519
SCOP:  3000092

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
StbA pfam06406
StbA protein; This family consists of several bacterial StbA plasmid stability proteins.
 2-319 0e+00

StbA protein; This family consists of several bacterial StbA plasmid stability proteins.


:

Pssm-ID: 310773 [Multi-domain]  Cd Length: 317  Bit Score: 523.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696    2 LKVSCDDGSTNVKLAWLEDGEVRTSLSGNSFKEGWNPGlFNAGKVYNYVVDEKKYTYDLGSTAVIGTTHVSYQYSTTNLL 81
Cdd:pfam06406   1 MKIFIDDGSTNIKLAWLEDGEVKTLISPNSFKPEWSVS-LGDKKPFNYEIDGEKYSFDPLSPDAVVTTDTSYQYSDVNVV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696   82 AIHHALLTSGLQPQDVELTVTLPVTEFFDNDNQPNEERIERKKANVLREISLNKGETFKIKKVNVMPESLPAAFESLKkd 161
Cdd:pfam06406  80 AIHHALLTSGLPPQDVDVVVTLPLSEYYDANNQPNMENIERKKANVMRPVELQGGETFTIRSVSVMPESIPAGFEVLK-- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696  162 KVNKLERSLIIDLGGTTLDCGLILGAFEGISEIRGYSEIGTSRITHTVMNALTKASTPCNYFIADELIKNRHDNEYLQTL 241
Cdd:pfam06406 158 DLDELESLLIIDLGGTTLDVAHVRGKLEGISKIYGDPSIGVSLITDAVKDALATASTRTSSYIADDLIIHRHDNNYLKQR 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696  242 INDVAEIKNISHVIDREVKSLAESIRQEISTFSGMNRIYLTGGGAELIYPHIKQYF--PNLKVNKVDEPQFALVKAMVHA 319
Cdd:pfam06406 238 INNEDKRASVMEVINEAVKKLEQRVIRALSRFSGYTHVMVVGGGAELIATAIKKHTgvPDARFIKVDNPQFALVNGMYAM 317
 
Name Accession Description Interval E-value
StbA pfam06406
StbA protein; This family consists of several bacterial StbA plasmid stability proteins.
 2-319 0e+00

StbA protein; This family consists of several bacterial StbA plasmid stability proteins.


Pssm-ID: 310773 [Multi-domain]  Cd Length: 317  Bit Score: 523.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696    2 LKVSCDDGSTNVKLAWLEDGEVRTSLSGNSFKEGWNPGlFNAGKVYNYVVDEKKYTYDLGSTAVIGTTHVSYQYSTTNLL 81
Cdd:pfam06406   1 MKIFIDDGSTNIKLAWLEDGEVKTLISPNSFKPEWSVS-LGDKKPFNYEIDGEKYSFDPLSPDAVVTTDTSYQYSDVNVV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696   82 AIHHALLTSGLQPQDVELTVTLPVTEFFDNDNQPNEERIERKKANVLREISLNKGETFKIKKVNVMPESLPAAFESLKkd 161
Cdd:pfam06406  80 AIHHALLTSGLPPQDVDVVVTLPLSEYYDANNQPNMENIERKKANVMRPVELQGGETFTIRSVSVMPESIPAGFEVLK-- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696  162 KVNKLERSLIIDLGGTTLDCGLILGAFEGISEIRGYSEIGTSRITHTVMNALTKASTPCNYFIADELIKNRHDNEYLQTL 241
Cdd:pfam06406 158 DLDELESLLIIDLGGTTLDVAHVRGKLEGISKIYGDPSIGVSLITDAVKDALATASTRTSSYIADDLIIHRHDNNYLKQR 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696  242 INDVAEIKNISHVIDREVKSLAESIRQEISTFSGMNRIYLTGGGAELIYPHIKQYF--PNLKVNKVDEPQFALVKAMVHA 319
Cdd:pfam06406 238 INNEDKRASVMEVINEAVKKLEQRVIRALSRFSGYTHVMVVGGGAELIATAIKKHTgvPDARFIKVDNPQFALVNGMYAM 317
ASKHA_NBD_ParM_R1-like cd24022
nucleotide-binding domain (NBD) of Escherichia coli plasmid segregation protein ParM and ...
 4-316 1.50e-85

nucleotide-binding domain (NBD) of Escherichia coli plasmid segregation protein ParM and similar proteins from ParM domain family; Type II plasmid partition systems utilize ParM NTPases in coordination with a centromere-binding protein called ParR to mediate accurate DNA segregation, a process critical for plasmid retention. The family corresponds to a group of uncharacterized proteins similar to Escherichia coli ParM, also called ParA locus 36 kDa protein, or protein StbA. It is a plasmid-encoded protein involved in the control of plasmid partition and required for accurate segregation of low-copy-number plasmid R1.


Pssm-ID: 466872 [Multi-domain]  Cd Length: 324  Bit Score: 260.28  E-value: 1.50e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696   4 VSCDDGSTNVKLAWLE-DGEVRTSLSGNSFKEGWNP--GLFNAGKVYNYVVDEKKYTYDLGSTAVIGTTHVSYQYSTTNL 80
Cdd:cd24022    1 VGIDDGSANIKVAWGEdDGKIKTFKIPSRARRGAAVsgSLGGGSQVFNYEVDGERYTVGDVVSDPIDTRNDDYQTSDLNR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696  81 LAIHHALLTSGLQPQDVELTVTLPVTEFFDNDNQPNEERIERKKANVLREISLNKG-ETFKIKKVNVMPESLPAAFESLK 159
Cdd:cd24022   81 VLVHHALHQAGLGGRKVDIVTGLPVSQYYYKDGQKNTELIERKKKNLKKPVTLLGGkSPATIVSVKVMPEGVAAYFDYLL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696 160 KDKVNKL------ERSLIIDLGGTTLDCGLILGAFEGISEIRGYSEIGTSRITHTVMNALTKASTPCNYFIA--DELIKN 231
Cdd:cd24022  161 DEDGNGTdeeeeeGPVAVIDIGGTTTDIAVVSGGLSIDHARSGTIELGVLDVRDALKDALKKRFGLSSISDAelDRALRT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696 232 RHDNeylqtliNDVAEIKNISHVIDREVKSLAESIRQEIS----TFSGMNRIYLTGGGAELIYPHIKQ-YFPNLKVnkVD 306
Cdd:cd24022  241 GKFR-------LNGGKEVDVSDLVNEAIAEVAERILNEIKrrlgDASDLDRVIFVGGGAELLEDELKEaLGPNAII--VD 311

                        330
                 ....*....|
gi 446844696 307 EPQFALVKAM 316
Cdd:cd24022  312 EPEFANARGM 321
PRK13917 PRK13917
plasmid segregation protein ParM; Provisional
 257-314 1.36e-03

plasmid segregation protein ParM; Provisional


Pssm-ID: 184393 [Multi-domain]  Cd Length: 344  Bit Score: 39.88  E-value: 1.36e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446844696 257 REVKSLAESIRQEIS----TFSGMNRIYLTGGGAELIYPHIKQYFPnlKVNKVDEPQFALVK 314
Cdd:PRK13917 269 KEQDSVIDEVMSGFEiavgNINSFDRVIVTGGGANIFFDSLSHWYS--DVEKADESQFANVR 328
 
Name Accession Description Interval E-value
StbA pfam06406
StbA protein; This family consists of several bacterial StbA plasmid stability proteins.
 2-319 0e+00

StbA protein; This family consists of several bacterial StbA plasmid stability proteins.


Pssm-ID: 310773 [Multi-domain]  Cd Length: 317  Bit Score: 523.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696    2 LKVSCDDGSTNVKLAWLEDGEVRTSLSGNSFKEGWNPGlFNAGKVYNYVVDEKKYTYDLGSTAVIGTTHVSYQYSTTNLL 81
Cdd:pfam06406   1 MKIFIDDGSTNIKLAWLEDGEVKTLISPNSFKPEWSVS-LGDKKPFNYEIDGEKYSFDPLSPDAVVTTDTSYQYSDVNVV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696   82 AIHHALLTSGLQPQDVELTVTLPVTEFFDNDNQPNEERIERKKANVLREISLNKGETFKIKKVNVMPESLPAAFESLKkd 161
Cdd:pfam06406  80 AIHHALLTSGLPPQDVDVVVTLPLSEYYDANNQPNMENIERKKANVMRPVELQGGETFTIRSVSVMPESIPAGFEVLK-- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696  162 KVNKLERSLIIDLGGTTLDCGLILGAFEGISEIRGYSEIGTSRITHTVMNALTKASTPCNYFIADELIKNRHDNEYLQTL 241
Cdd:pfam06406 158 DLDELESLLIIDLGGTTLDVAHVRGKLEGISKIYGDPSIGVSLITDAVKDALATASTRTSSYIADDLIIHRHDNNYLKQR 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696  242 INDVAEIKNISHVIDREVKSLAESIRQEISTFSGMNRIYLTGGGAELIYPHIKQYF--PNLKVNKVDEPQFALVKAMVHA 319
Cdd:pfam06406 238 INNEDKRASVMEVINEAVKKLEQRVIRALSRFSGYTHVMVVGGGAELIATAIKKHTgvPDARFIKVDNPQFALVNGMYAM 317
ASKHA_NBD_ParM_R1-like cd24022
nucleotide-binding domain (NBD) of Escherichia coli plasmid segregation protein ParM and ...
 4-316 1.50e-85

nucleotide-binding domain (NBD) of Escherichia coli plasmid segregation protein ParM and similar proteins from ParM domain family; Type II plasmid partition systems utilize ParM NTPases in coordination with a centromere-binding protein called ParR to mediate accurate DNA segregation, a process critical for plasmid retention. The family corresponds to a group of uncharacterized proteins similar to Escherichia coli ParM, also called ParA locus 36 kDa protein, or protein StbA. It is a plasmid-encoded protein involved in the control of plasmid partition and required for accurate segregation of low-copy-number plasmid R1.


Pssm-ID: 466872 [Multi-domain]  Cd Length: 324  Bit Score: 260.28  E-value: 1.50e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696   4 VSCDDGSTNVKLAWLE-DGEVRTSLSGNSFKEGWNP--GLFNAGKVYNYVVDEKKYTYDLGSTAVIGTTHVSYQYSTTNL 80
Cdd:cd24022    1 VGIDDGSANIKVAWGEdDGKIKTFKIPSRARRGAAVsgSLGGGSQVFNYEVDGERYTVGDVVSDPIDTRNDDYQTSDLNR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696  81 LAIHHALLTSGLQPQDVELTVTLPVTEFFDNDNQPNEERIERKKANVLREISLNKG-ETFKIKKVNVMPESLPAAFESLK 159
Cdd:cd24022   81 VLVHHALHQAGLGGRKVDIVTGLPVSQYYYKDGQKNTELIERKKKNLKKPVTLLGGkSPATIVSVKVMPEGVAAYFDYLL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696 160 KDKVNKL------ERSLIIDLGGTTLDCGLILGAFEGISEIRGYSEIGTSRITHTVMNALTKASTPCNYFIA--DELIKN 231
Cdd:cd24022  161 DEDGNGTdeeeeeGPVAVIDIGGTTTDIAVVSGGLSIDHARSGTIELGVLDVRDALKDALKKRFGLSSISDAelDRALRT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696 232 RHDNeylqtliNDVAEIKNISHVIDREVKSLAESIRQEIS----TFSGMNRIYLTGGGAELIYPHIKQ-YFPNLKVnkVD 306
Cdd:cd24022  241 GKFR-------LNGGKEVDVSDLVNEAIAEVAERILNEIKrrlgDASDLDRVIFVGGGAELLEDELKEaLGPNAII--VD 311

                        330
                 ....*....|
gi 446844696 307 EPQFALVKAM 316
Cdd:cd24022  312 EPEFANARGM 321
ASKHA_NBD_ParM-like cd10227
nucleotide-binding domain (NBD) of the plasmid segregation protein ParM-like domain family; ...
 4-316 2.27e-22

nucleotide-binding domain (NBD) of the plasmid segregation protein ParM-like domain family; ParM is a plasmid-encoded bacterial homolog of actin, which polymerizes into filaments similar to F-actin, and plays a vital role in plasmid segregation. ParM filaments segregate plasmids paired at midcell into the individual daughter cells. This subfamily also contains Thermoplasma acidophilum Ta0583, an active ATPase at physiological temperatures, which has a propensity to form filaments. ParM-like proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466825 [Multi-domain]  Cd Length: 263  Bit Score: 94.13  E-value: 2.27e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696   4 VSCDDGSTNVKLAWLEDGEVRTSlsgNSFKEGWNPGLFNAGKVYNYVVDEKKYTYDLGSTAV-----IGTTHVSYQYSTT 78
Cdd:cd10227    1 IGIDIGNGNTKVVTGGGKEFKFP---SAVAEARESSLDDGLLEDDIIVEYNGKRYLVGELALregggGRSTGDDKKKSED 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696  79 NLLAIHHALLTSGLQP-QDVELTVTLPVTEFFDNdnqpnEERIERKKANVLREISLN-KGETFKIKKVNVMPESLPAAFE 156
Cdd:cd10227   78 ALLLLLAALALLGDDEeVDVNLVVGLPISEYKEE-----KKELKKKLLKGLHEFTFNgKERRITINDVKVLPEGAGAYLD 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696 157 SLKKDKVNKLERSLIIDLGGTTLDcglILGAFEG-ISEIRGYSEIGtsrithtvmnaltkastpcnyfiadeliknrhDN 235
Cdd:cd10227  153 YLLDDDELEDGNVLVIDIGGGTTD---ILTFENGkPIEESSDTLPG--------------------------------GE 197

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696 236 EYLQTLINDVaeiknISHVIDREVKSLAESirqeistfsgmNRIYLTGGGAELIYPHIKQ-YFPNLKVnkVDEPQFALVK 314
Cdd:cd10227  198 EALEKYADDI-----LNELLKKLGDELDSA-----------DKILLTGGGAELLKDYLKEaYFPNIIV--LDDPQFANAR 259


                 ..
gi 446844696 315 AM 316
Cdd:cd10227  260 GL 261
ASKHA_NBD_ParM_pCBH-like cd24025
nucleotide-binding domain (NBD) of Clostridium botulinum plasmid segregation protein ParM and ...
 48-311 1.50e-18

nucleotide-binding domain (NBD) of Clostridium botulinum plasmid segregation protein ParM and similar proteins from the ParM domain family; The family corresponds to a group of uncharacterized proteins similar to Clostridium botulinum pCBH plasmid segregation protein ParM, an actin-like polymerizing motor. pCBH ParM filament structure is far more complex in comparison to the known filament structures of actin, MreB, and other ParMs. It is bipolar and stiff and like microtubules. The 15 polymerizing strands are likely to exert greater combined force relative to typical two-stranded actin-like filaments.


Pssm-ID: 466875 [Multi-domain]  Cd Length: 326  Bit Score: 84.64  E-value: 1.50e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696  48 NYVVDEKKYTYDLGSTAVIGTTHVSYQYSTTNLLAIHH-ALLTSGL------QPQDVELTVTLPVTEFFDNDNQPnEERI 120
Cdd:cd24025   48 RLAVTIDGEEYFVGELALRQSRALELTLDRDKANSEETrVLLLTALallaaeDDEPVSLVTGLPLSYYKTQKEAL-EEML 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696 121 ERKKANVLREISLNKGEtFKIKKVNVMPESLPAAFESLKKDKVNKLERSL------IIDLGGTTLDCGLilgaFE-GISE 193
Cdd:cd24025  127 KGLHAVVVGVDGGTEKR-ITIDRVRVFPQGAGALYDALLDDDGQIIDKALakgrvgVIDIGYRTTDYVV----FEdGEFL 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696 194 IRGYS---EIGTSRITHTVMNALTKAST-PCNYFIADELIKNRhdneylQTLINdvAEIKNISHVIDREVKSLAESIRQE 269
Cdd:cd24025  202 VPELSgslETGMSTAYRAIANALEEEYGiDLDLHELDRALREG------KIRVR--GKEIDLSDLIDEALKELARQIANE 273

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 446844696 270 ISTFSG-----MNRIYLTGGGAELIYPHIKQYFPNLKVnkVDEPQFA 311
Cdd:cd24025  274 IRSLWGdglgdLDAIILAGGGAELLAPYLKEMFPNAEV--VPDPQFA 318
ASKHA_NBD_ParM_Psk41-like cd24021
nucleotide-binding domain (NBD) of Staphylococcus aureus pSK41 actin-like ParM protein and ...
 23-314 5.15e-16

nucleotide-binding domain (NBD) of Staphylococcus aureus pSK41 actin-like ParM protein and similar proteins from the ParM domain family; Type II plasmid partition systems utilize ParM NTPases in coordination with a centromere-binding protein called ParR to mediate accurate DNA segregation, a process critical for plasmid retention. The family corresponds to a group of uncharacterized proteins similar to Staphylococcus aureus pSK41 actin-like ParM protein, which is functionally homologous to R1 ParM, a known actin homologue, suggesting that it may also form filaments to drive partition. However, pSK41 ParM shows the strongest structural homology to the archaeal actin-like protein Thermoplasma acidophilum Ta0583, but not R1 ParM.


Pssm-ID: 466871 [Multi-domain]  Cd Length: 298  Bit Score: 76.94  E-value: 5.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696  23 VRTSLSGNSFKEGWNPGLFNAGKVYN---YVVDEKKYtyDLGSTAVIGTTHV------SYQYSTTNLLAIhhALLTSGLQ 93
Cdd:cd24021   26 LEAKDVGNEDLFGDKDYVETYSFNNNgeeYVWGEDIY--KSGKDEEIASTYSgedrykSEEFKLLSLIAL--AKLAKDYD 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696  94 PQDVELTVT--LPVTEFfdndnqpNEERIERKKANVLREISLN---KGETFKIKKVNVMPESLPAAFESLKKDKVNKLER 168
Cdd:cd24021  102 EDVVEVVVVtgLPSEDY-------DTEVEEELKKVLKGEHTVKingKERTINVKDVYVIPQPLGTLYNLLLDENGEVKNE 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696 169 S------LIIDLGGTTLDcglilgafegISEIRGYseigtsrithtvmnaltkastpcnyfiadELIKNRHDNEY-LQTL 241
Cdd:cd24021  175 EledskvLIIDIGGGTTD----------VDVINGL-----------------------------KIDENRFQIETgMKDV 215

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446844696 242 INDVAEiKNISHVIDREVKSLAESIRQEIST----FSGMNRIYLTGGGAELIYPHIKQYFPNLKVNKVDEPQFALVK 314
Cdd:cd24021  216 YDEIAK-EDITEIVEKAIEEYAEEIVAEINNafkdLDSFDKVIFTGGGANILNKYLKEKLEGDNFVFVENPQTANVR 291
ASKHA_NBD_ParM_Alp12-like cd24026
nucleotide-binding domain (NBD) of Clostridium tetani actin-like protein Alp12 and similar ...
 57-314 2.16e-12

nucleotide-binding domain (NBD) of Clostridium tetani actin-like protein Alp12 and similar proteins from the ParM domain family; The family corresponds to a group of uncharacterized proteins similar to Clostridium tetani actin-like protein Alp12. It is a dynamically unstable force-generating motor involved in segregating the pE88 plasmid, which encodes the lethal tetanus toxin. Alp12 filaments have a unique polymer structure that is entirely different from F-actin and display dynamic behavior like microtubules. Alp12 can be repeatedly cycled between states of polymerization and dissociation, making it a novel candidate for incorporation into fuel-propelled nanobiopolymer machines.


Pssm-ID: 466876 [Multi-domain]  Cd Length: 308  Bit Score: 66.54  E-value: 2.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696  57 TYDlGSTAVIG--TTHVSYQYSTTNLL-------AIHHALLTSglQPQDVELTVTLPVTEFFDNDNQpnEERIERKKANV 127
Cdd:cd24026   49 EYD-GKEYLIGeqGEEYDYDTSKASLLhklctytAIAKLLEND--KGNEVNLVVGCPLNIYKNKELK--EEYKEFIKGNG 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696 128 LREISLN-KGETFKIKKVNVMPESLPAAF---ESLKKDKVnklersLIIDLGGTTLDCGLilgaFEGISEIRGYS---EI 200
Cdd:cd24026  124 KIIIIVNgEKKSFKITDVTVKPEGSGVIYrnpEKFKNKNV------GVIDIGGLNVNFCI----YDNGIPIPESMftdNL 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696 201 GTSRITHTVMNALTKA--STPCNYfIADELIKNRHdNEYLQTLINDVAEIknISHVIDREVKSLAESIRQEISTFSGMnR 278
Cdd:cd24026  194 GGNVLENKIKEALNSYfgGNIQDY-DILNILINGY-IKFNGEIEEESKEI--IEEIKDEHLKEIINKIKSRKWNLENM-D 268

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 446844696 279 IYLTGGGAELIYPHIKQYFPNLKVNkvDEPQFALVK 314
Cdd:cd24026  269 IIFVGGTSLLLKDYIKELFPNATIS--EDAQWDNVE 302
ASKHA_NBD_ParM_Alp7A-like cd24023
nucleotide-binding domain (NBD) of Bacillus subtilis actin-like protein Alp7A and similar ...
 96-297 2.29e-07

nucleotide-binding domain (NBD) of Bacillus subtilis actin-like protein Alp7A and similar proteins from the ParM domain family; The family corresponds to a group of uncharacterized proteins similar to Bacillus subtilis actin-like protein Alp7A, a plasmid partitioning protein that functions in plasmid segregation. The subfamily also includes Bacillus thuringiensis ParM hybrid fusion protein.


Pssm-ID: 466873 [Multi-domain]  Cd Length: 368  Bit Score: 51.56  E-value: 2.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696  96 DVELTVTLPVTEFFDNDNQpneERIERKKANVlREISLNKGE------TFKIKKVNVMPESLPAAFeSLKKDKVNKL--- 166
Cdd:cd24023  124 KVDLSTGLPISEYKKEGAK---EFFERFLKGE-HTVTFLDGPgkgvtvTIKFEDVKVLPEGVAALF-ALIYDEDGNErve 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696 167 ---------ERSLIIDLGGTTLDCGLilgaFEGISEIRGYSEiGTSRITHTVMNALTKA---STPCNYFIADELIKNRHD 234
Cdd:cd24023  199 dtededlkeKNILIIDIGGGTTDVAV----FEGGKFDPDLST-GIDLGIGTALDEIIKElkkEYGVEFDRRRLLFELIIK 273

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446844696 235 NEYLQTLINdvAEIKNISHVIDREVKSLAESIRQEISTFSGMN-----RIYLTGGGAELIYPHIKQYF 297
Cdd:cd24023  274 KKEYKDKNR--GKKVDLTDIVEKALEELAEEILDEIEKKWNKAgndieVIYVYGGGSILLKDYLKELL 339
ASKHA_NBD_PilM-like cd24004
nucleotide-binding domain (NBD) of the PilM-like domain family; The PilM-like family includes ...
 144-305 5.63e-05

nucleotide-binding domain (NBD) of the PilM-like domain family; The PilM-like family includes type IV pilus inner membrane component PilM, cell division protein FtsA, and ethanolamine utilization protein EutJ. PilM is an inner membrane component of the type IV (T4S) secretion system that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility. FtsA is an essential cell division protein that assists in the assembly of the Z ring. It may serve as the principal membrane anchor for the Z ring. It is also required for the recruitment to the septal ring of the downstream cell division proteins FtsK, FtsQ, FtsL, FtsI and FtsN. EutJ may protect ethanolamine ammonia-lyase (EAL, eutB-eutC) from inhibition. It may also function in assembling the bacterial microcompartment and/or in refolding EAL, suggesting it may have chaperone activity. Members in PilM-like family belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466854 [Multi-domain]  Cd Length: 282  Bit Score: 43.82  E-value: 5.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696 144 VNVMPESlPAAFESLKKDKVNKLErSLIIDLGGTTLDcglilgafegISEIRGYSEIGTSR-------ITHTVMNALTka 216
Cdd:cd24004   93 VGLTLEP-FAAANLLIPYDMRDLN-IALVDIGAGTTD----------IALIRNGGIEAYRMvplggddFTKAIAEGFL-- 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696 217 stpCNYFIADELIKN--RHDNEYLQTLINDVAEIKNISHVIDREVKSLAESIRQEISTFSGM----NRIYLTGGGAELiy 290
Cdd:cd24004  159 ---ISFEEAEKIKRTygIFLLIEAKDQLGFTINKKEVYDIIKPVLEELASGIANAIEEYNGKfklpDAVYLVGGGSKL-- 233

                        170
                 ....*....|....*...
gi 446844696 291 PHIK---QYFPNLKVNKV 305
Cdd:cd24004  234 PGLNealAEKLGLPVERI 251
ASKHA_NBD_ParM_Ta0583-like cd24027
nucleotide-binding domain (NBD) of Thermoplasma acidophilum archaeal actin homolog and similar ...
 86-313 2.39e-04

nucleotide-binding domain (NBD) of Thermoplasma acidophilum archaeal actin homolog and similar proteins from the ParM domain family; The family corresponds to a group of uncharacterized proteins similar to Thermoplasma acidophilum archaeal actin homolog Ta0583, which is the archaeal counterpart of the eukaryotic structural protein actin, such as MreB and ParM. Ta0583 could have a function in cellular organization. It polymerizes into bundles of filaments, forming a helix with a filament width of 5.5 nm and an axial repeating unit of 5.5 nm. Polymerization of Ta0583 requires NTP and is optimal with ATP, but GTP, UTP, CTP, and even the deoxy form of NTP can also support the polymerization reaction. Nucleoside diphosphate or AMP-PNP does not support polymerization.


Pssm-ID: 466877 [Multi-domain]  Cd Length: 323  Bit Score: 42.22  E-value: 2.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696  86 ALLTSGLQ---PQDVELTVTLPVTEFFDndnqpnEERIERKKANVLREISLNKGET---FKIKKVNVMPESLPAAFESLK 159
Cdd:cd24027   87 ALWESGIHndsPVDLFLGTGLPLGTFDL------EVKAAKEALENKVLTVTGPEGEvrkINITRLEIRPQGVGAALYLLN 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696 160 KDKVNKLERS----LIIDLGGTTLDCGLIlGAFEGISEIRGYS---EIGTSRITHTVMNALTKASTPCNYFIADELIKNr 232
Cdd:cd24027  161 QGIIEESEQQpgygVVIDVGSRTTDVLTI-RLGDVVELSFSLQigvAVYGRAIKALSRKIAKETGFVVPFDLAQEALSH- 238

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696 233 hdneylQTLINDVAEIkNISHVIDREVKSLAESIRQEISTFSG--MNRI---YLTGGGAELIYPHIKQYFPNLKVNKVDE 307
Cdd:cd24027  239 ------PVLFRQKEQV-DGPEVSGPILEDLANRIIENIRLNLRgeVDRVtslLLVGGGSNLIGDRFEEIAPGTLVKIKPE 311


                 ....*.
gi 446844696 308 PQFALV 313
Cdd:cd24027  312 DQFANV 317
ASKHA_NBD_PilM cd24049
nucleotide-binding domain (NBD) of type IV pilus inner membrane component PilM and similar ...
 139-297 5.46e-04

nucleotide-binding domain (NBD) of type IV pilus inner membrane component PilM and similar proteins; PilM is an inner membrane component of the type IV (T4S) secretion system that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility. PilN/PilO heterodimers form the foundation of the inner-membrane PilM/PilN/PilO/PilP complex which plays an essential role in the assembly of a functional T4 pilus. In turn, PilM associates with PilN and facilitates PilM functionally relevant structural changes that differentially impacts PilM binding to PilB, PilT, and PilC.


Pssm-ID: 466899 [Multi-domain]  Cd Length: 339  Bit Score: 41.11  E-value: 5.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696 139 FKIKKVNVMPESLPAAFESLKKDKVNklERSLIIDLGGTTLDCGLIL-GAFEGISEIrgysEIGTSRITHTVMNAL---- 213
Cdd:cd24049  150 LKPVAIDVESFALARALEYLLPDEEE--ETVALLDIGASSTTLVIVKnGKLLFTRSI----PVGGNDITEAIAKALglsf 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446844696 214 TKAstpcnyfiadELIKNRHDNEylqtLINDVAEIKNISHVIDREVKSLAESIRQEISTFSGMN------RIYLTGGGAE 287
Cdd:cd24049  224 EEA----------EELKREYGLL----LEGEEGELKKVAEALRPVLERLVSEIRRSLDYYRSQNggepidKIYLTGGGSL 289

                        170
                 ....*....|
gi 446844696 288 LiyPHIKQYF 297
Cdd:cd24049  290 L--PGLDEYL 297
PRK13917 PRK13917
plasmid segregation protein ParM; Provisional
 257-314 1.36e-03

plasmid segregation protein ParM; Provisional


Pssm-ID: 184393 [Multi-domain]  Cd Length: 344  Bit Score: 39.88  E-value: 1.36e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446844696 257 REVKSLAESIRQEIS----TFSGMNRIYLTGGGAELIYPHIKQYFPnlKVNKVDEPQFALVK 314
Cdd:PRK13917 269 KEQDSVIDEVMSGFEiavgNINSFDRVIVTGGGANIFFDSLSHWYS--DVEKADESQFANVR 328
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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