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Conserved domains on  [gi|446795559|ref|WP_000872815|]
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MULTISPECIES: N-methyl-L-tryptophan oxidase [Enterobacteriaceae]

Protein Classification

N-methyl-L-tryptophan oxidase( domain architecture ID 11485285)

N-methyl-L-tryptophan oxidase catalyzes the oxidative demethylation of N-methyl-L-tryptophan to form L-tryptophan

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
solA PRK11259
N-methyl-L-tryptophan oxidase;
1-372 0e+00

N-methyl-L-tryptophan oxidase;


:

Pssm-ID: 236887 [Multi-domain]  Cd Length: 376  Bit Score: 656.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559   1 MKYDLIIIGSGSVGAAAGYYATRAGLNVLMTDAHMPPHQHGSHHGDTRLIRHAYGEGEKYVPLVLRAQTLWDELSRHNED 80
Cdd:PRK11259   2 MRYDVIVIGLGSMGSAAGYYLARRGLRVLGLDRFMPPHQQGSSHGDTRIIRHAYGEGPAYVPLVLRAQELWRELERESGE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559  81 dPIFVRSGVINLGPADSAFLANVAHSAEQWQLNVEKLDAQGIMARWPEIRVPDNYIGLFETDSGFLRSELAIKTWIQLAK 160
Cdd:PRK11259  82 -PLFVRTGVLNLGPADSDFLANSIRSARQHGLPHEVLDAAEIRRRFPQFRLPDGYIALFEPDGGFLRPELAIKAHLRLAR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559 161 EAGCAQLFNCPVTAIRHDDDGVTIETVDGEYQAKKAIVCAGTWVKDLLPEL--PVQPVRKVFAWYQADGRYSVKNKFPAF 238
Cdd:PRK11259 161 EAGAELLFNEPVTAIEADGDGVTVTTADGTYEAKKLVVSAGAWVKDLLPPLelPLTPVRQVLAWFQADGRYSEPNRFPAF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559 239 TGELPNGDQYYGFPAENDA-LKIGKHNGGQVIHSADERVPFAEVVSDGSEAFPFLRNVLPGIGCCLYGAACTYDNSPDED 317
Cdd:PRK11259 241 IWEVPDGDQYYGFPAENGPgLKIGKHNGGQEITSPDERDRFVTVAEDGAELRPFLRNYLPGVGPCLRGAACTYTNTPDEH 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446795559 318 FIIDTLPGHDNTLLITGLSGHGFKFASVLGEIAADFAQDKKSDFDLTPFRLSRFQ 372
Cdd:PRK11259 321 FIIDTLPGHPNVLVASGCSGHGFKFASVLGEILADLAQDGTSDFDLSPFSLSRFA 375
 
Name Accession Description Interval E-value
solA PRK11259
N-methyl-L-tryptophan oxidase;
1-372 0e+00

N-methyl-L-tryptophan oxidase;


Pssm-ID: 236887 [Multi-domain]  Cd Length: 376  Bit Score: 656.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559   1 MKYDLIIIGSGSVGAAAGYYATRAGLNVLMTDAHMPPHQHGSHHGDTRLIRHAYGEGEKYVPLVLRAQTLWDELSRHNED 80
Cdd:PRK11259   2 MRYDVIVIGLGSMGSAAGYYLARRGLRVLGLDRFMPPHQQGSSHGDTRIIRHAYGEGPAYVPLVLRAQELWRELERESGE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559  81 dPIFVRSGVINLGPADSAFLANVAHSAEQWQLNVEKLDAQGIMARWPEIRVPDNYIGLFETDSGFLRSELAIKTWIQLAK 160
Cdd:PRK11259  82 -PLFVRTGVLNLGPADSDFLANSIRSARQHGLPHEVLDAAEIRRRFPQFRLPDGYIALFEPDGGFLRPELAIKAHLRLAR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559 161 EAGCAQLFNCPVTAIRHDDDGVTIETVDGEYQAKKAIVCAGTWVKDLLPEL--PVQPVRKVFAWYQADGRYSVKNKFPAF 238
Cdd:PRK11259 161 EAGAELLFNEPVTAIEADGDGVTVTTADGTYEAKKLVVSAGAWVKDLLPPLelPLTPVRQVLAWFQADGRYSEPNRFPAF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559 239 TGELPNGDQYYGFPAENDA-LKIGKHNGGQVIHSADERVPFAEVVSDGSEAFPFLRNVLPGIGCCLYGAACTYDNSPDED 317
Cdd:PRK11259 241 IWEVPDGDQYYGFPAENGPgLKIGKHNGGQEITSPDERDRFVTVAEDGAELRPFLRNYLPGVGPCLRGAACTYTNTPDEH 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446795559 318 FIIDTLPGHDNTLLITGLSGHGFKFASVLGEIAADFAQDKKSDFDLTPFRLSRFQ 372
Cdd:PRK11259 321 FIIDTLPGHPNVLVASGCSGHGFKFASVLGEILADLAQDGTSDFDLSPFSLSRFA 375
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 3-371 2.64e-97

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 294.04  E-value: 2.64e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559    3 YDLIIIGSGSVGAAAGYYATRAGLNVLMTDAHMPPHQHGSHHGDTRLIRHAYGEGEkYVPLVLRAQTLWDELsRHNEDDP 82
Cdd:TIGR01377   1 FDVIVVGAGIMGCFAAYHLAKHGKKTLLLEQFDLPHSRGSSHGQSRIIRKAYPEDF-YTPMMLECYQLWAQL-EKEAGTK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559   83 IFVRSGVINLGPADSAFLANVAHSAEQWQLNVEKLDAQGIMARWPEIRVPDNYIGLFETDSGFLRSELAIKTWIQLAKEA 162
Cdd:TIGR01377  79 LHRQTGLLLLGPKENQFLKTIQATLSRHGLEHELLSSKQLKQRFPNIRVPRNEVGLLDPNGGVLYAEKALRALQELAEAH 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559  163 GCAQLFNCPVTAIRHDDDGVTIETVDGEYQAKKAIVCAGTWVKDLLP----ELPVQPVRKVFAWYQAD--GRYSVKNKFP 236
Cdd:TIGR01377 159 GATVRDGTKVVEIEPTELLVTVKTTKGSYQANKLVVTAGAWTSKLLSplgiEIPLQPLRINVCYWREKepGSYGVSQAFP 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559  237 AFTGELPNGdQYYGFPA-ENDALKIGKHNGGQVIHSADERVPFAEVVSDGSEAFPFLRNVLPGI-GCCLYGAACTYDNSP 314
Cdd:TIGR01377 239 CFLVLGLNP-HIYGLPSfEYPGLMKVYYHHGQQIDPDERDCPFGADIEDVQILRKFVRDHLPGLnGEPKKGEVCMYTNTP 317

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 446795559  315 DEDFIIDTLPGHDNTLLITGLSGHGFKFASVLGEIAADFAQDKKSDFDLTPFRLSRF 371
Cdd:TIGR01377 318 DEHFVIDLHPKYDNVVIGAGFSGHGFKLAPVVGKILAELAMKLKPSYDLAIFSLNRF 374
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
1-370 5.12e-70

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 223.63  E-value: 5.12e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559   1 MKYDLIIIGSGSVGAAAGYYATRAGLNVLMTDAHMPPHqhGSHHGDTRLIRHAYGE--GEKYVPLVLRAQTLWDELSRHN 78
Cdd:COG0665    1 ATADVVVIGGGIAGLSTAYHLARRGLDVTVLERGRPGS--GASGRNAGQLRPGLAAlaDRALVRLAREALDLWRELAAEL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559  79 EDDPIFVRSGVINLG--PADSAFLANVAHSAEQWQLNVEKLDAQGIMARWPEIRVPDNYIGLFETDSGFLRSELAIKTWI 156
Cdd:COG0665   79 GIDCDFRRTGVLYLArtEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLYDPDDGHVDPAKLVRALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559 157 QLAKEAGCAQLFNCPVTAIRHDDDGVT-IETVDGEYQAKKAIVCAGTWVKDLLP----ELPVQPVRKVFAWYQADGRYsv 231
Cdd:COG0665  159 RAARAAGVRIREGTPVTGLEREGGRVTgVRTERGTVRADAVVLAAGAWSARLLPmlglRLPLRPVRGYVLVTEPLPDL-- 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559 232 kNKFPAFTGElpngdQYYGFPAENDALKIGkhnGGQVIHSADERVP---FAEVVSDGSEAFPFLRNVlpGIgccLYGAAC 308
Cdd:COG0665  237 -PLRPVLDDT-----GVYLRPTADGRLLVG---GTAEPAGFDRAPTperLEALLRRLRRLFPALADA--EI---VRAWAG 302

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446795559 309 TYDNSPDEDFIIDTLPGHDNTLLITGLSGHGFKFASVLGEIAADFAQDKKSDFDLTPFRLSR 370
Cdd:COG0665  303 LRPMTPDGLPIIGRLPGAPGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPDR 364
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 4-352 2.45e-48

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 166.42  E-value: 2.45e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559    4 DLIIIGSGSVGAAAGYYATRAGLNVLMTDAHMPPHQHGSHHGdTRLIRHAYGEGEK--YVPLVLRAQTLWDELSRHNEDD 81
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARRGLSVTLLERGDDPGSGASGRN-AGLIHPGLRYLEPseLARLALEALDLWEELEEELGID 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559   82 PIFVRSGVINLG-PADSAFLANVAHSAEQWQLNVEKLDAQGIMARWPEirVPDNYIGLFETDSGFLRSELAIKTWIQLAK 160
Cdd:pfam01266  80 CGFRRCGVLVLArDEEEEALEKLLAALRRLGVPAELLDAEELRELEPL--LPGLRGGLFYPDGGHVDPARLLRALARAAE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559  161 EAGCAQLFNCPVTAIRHDDDGVTIETvDGEYQAkkAIVCAGTWVKDLLPELPVQPVRKVFAWYQADGRYSVKNKFPAFTG 240
Cdd:pfam01266 158 ALGVRIIEGTEVTGIEEEGGVWGVVT-TGEADA--VVNAAGAWADLLALPGLRLPVRPVRGQVLVLEPLPEALLILPVPI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559  241 ELPNGDQYYGFPAENDALKIGkhnGGQVIHSADERVPFAEVVsdgSEAFPFLRNVLPGIGCCLYGAACTYDnSPDEDFII 320
Cdd:pfam01266 235 TVDPGRGVYLRPRADGRLLLG---GTDEEDGFDDPTPDPEEI---EELLEAARRLFPALADIERAWAGLRP-LPDGLPII 307

                         330       340       350
                  ....*....|....*....|....*....|..
gi 446795559  321 DTlPGHDNTLLITGLSGHGFKFASVLGEIAAD 352
Cdd:pfam01266 308 GR-PGSPGLYLATGHGGHGLTLAPGIGKLLAE 338
 
Name Accession Description Interval E-value
solA PRK11259
N-methyl-L-tryptophan oxidase;
1-372 0e+00

N-methyl-L-tryptophan oxidase;


Pssm-ID: 236887 [Multi-domain]  Cd Length: 376  Bit Score: 656.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559   1 MKYDLIIIGSGSVGAAAGYYATRAGLNVLMTDAHMPPHQHGSHHGDTRLIRHAYGEGEKYVPLVLRAQTLWDELSRHNED 80
Cdd:PRK11259   2 MRYDVIVIGLGSMGSAAGYYLARRGLRVLGLDRFMPPHQQGSSHGDTRIIRHAYGEGPAYVPLVLRAQELWRELERESGE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559  81 dPIFVRSGVINLGPADSAFLANVAHSAEQWQLNVEKLDAQGIMARWPEIRVPDNYIGLFETDSGFLRSELAIKTWIQLAK 160
Cdd:PRK11259  82 -PLFVRTGVLNLGPADSDFLANSIRSARQHGLPHEVLDAAEIRRRFPQFRLPDGYIALFEPDGGFLRPELAIKAHLRLAR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559 161 EAGCAQLFNCPVTAIRHDDDGVTIETVDGEYQAKKAIVCAGTWVKDLLPEL--PVQPVRKVFAWYQADGRYSVKNKFPAF 238
Cdd:PRK11259 161 EAGAELLFNEPVTAIEADGDGVTVTTADGTYEAKKLVVSAGAWVKDLLPPLelPLTPVRQVLAWFQADGRYSEPNRFPAF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559 239 TGELPNGDQYYGFPAENDA-LKIGKHNGGQVIHSADERVPFAEVVSDGSEAFPFLRNVLPGIGCCLYGAACTYDNSPDED 317
Cdd:PRK11259 241 IWEVPDGDQYYGFPAENGPgLKIGKHNGGQEITSPDERDRFVTVAEDGAELRPFLRNYLPGVGPCLRGAACTYTNTPDEH 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446795559 318 FIIDTLPGHDNTLLITGLSGHGFKFASVLGEIAADFAQDKKSDFDLTPFRLSRFQ 372
Cdd:PRK11259 321 FIIDTLPGHPNVLVASGCSGHGFKFASVLGEILADLAQDGTSDFDLSPFSLSRFA 375
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 3-371 2.64e-97

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 294.04  E-value: 2.64e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559    3 YDLIIIGSGSVGAAAGYYATRAGLNVLMTDAHMPPHQHGSHHGDTRLIRHAYGEGEkYVPLVLRAQTLWDELsRHNEDDP 82
Cdd:TIGR01377   1 FDVIVVGAGIMGCFAAYHLAKHGKKTLLLEQFDLPHSRGSSHGQSRIIRKAYPEDF-YTPMMLECYQLWAQL-EKEAGTK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559   83 IFVRSGVINLGPADSAFLANVAHSAEQWQLNVEKLDAQGIMARWPEIRVPDNYIGLFETDSGFLRSELAIKTWIQLAKEA 162
Cdd:TIGR01377  79 LHRQTGLLLLGPKENQFLKTIQATLSRHGLEHELLSSKQLKQRFPNIRVPRNEVGLLDPNGGVLYAEKALRALQELAEAH 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559  163 GCAQLFNCPVTAIRHDDDGVTIETVDGEYQAKKAIVCAGTWVKDLLP----ELPVQPVRKVFAWYQAD--GRYSVKNKFP 236
Cdd:TIGR01377 159 GATVRDGTKVVEIEPTELLVTVKTTKGSYQANKLVVTAGAWTSKLLSplgiEIPLQPLRINVCYWREKepGSYGVSQAFP 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559  237 AFTGELPNGdQYYGFPA-ENDALKIGKHNGGQVIHSADERVPFAEVVSDGSEAFPFLRNVLPGI-GCCLYGAACTYDNSP 314
Cdd:TIGR01377 239 CFLVLGLNP-HIYGLPSfEYPGLMKVYYHHGQQIDPDERDCPFGADIEDVQILRKFVRDHLPGLnGEPKKGEVCMYTNTP 317

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 446795559  315 DEDFIIDTLPGHDNTLLITGLSGHGFKFASVLGEIAADFAQDKKSDFDLTPFRLSRF 371
Cdd:TIGR01377 318 DEHFVIDLHPKYDNVVIGAGFSGHGFKLAPVVGKILAELAMKLKPSYDLAIFSLNRF 374
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
1-370 5.12e-70

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 223.63  E-value: 5.12e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559   1 MKYDLIIIGSGSVGAAAGYYATRAGLNVLMTDAHMPPHqhGSHHGDTRLIRHAYGE--GEKYVPLVLRAQTLWDELSRHN 78
Cdd:COG0665    1 ATADVVVIGGGIAGLSTAYHLARRGLDVTVLERGRPGS--GASGRNAGQLRPGLAAlaDRALVRLAREALDLWRELAAEL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559  79 EDDPIFVRSGVINLG--PADSAFLANVAHSAEQWQLNVEKLDAQGIMARWPEIRVPDNYIGLFETDSGFLRSELAIKTWI 156
Cdd:COG0665   79 GIDCDFRRTGVLYLArtEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLYDPDDGHVDPAKLVRALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559 157 QLAKEAGCAQLFNCPVTAIRHDDDGVT-IETVDGEYQAKKAIVCAGTWVKDLLP----ELPVQPVRKVFAWYQADGRYsv 231
Cdd:COG0665  159 RAARAAGVRIREGTPVTGLEREGGRVTgVRTERGTVRADAVVLAAGAWSARLLPmlglRLPLRPVRGYVLVTEPLPDL-- 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559 232 kNKFPAFTGElpngdQYYGFPAENDALKIGkhnGGQVIHSADERVP---FAEVVSDGSEAFPFLRNVlpGIgccLYGAAC 308
Cdd:COG0665  237 -PLRPVLDDT-----GVYLRPTADGRLLVG---GTAEPAGFDRAPTperLEALLRRLRRLFPALADA--EI---VRAWAG 302

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446795559 309 TYDNSPDEDFIIDTLPGHDNTLLITGLSGHGFKFASVLGEIAADFAQDKKSDFDLTPFRLSR 370
Cdd:COG0665  303 LRPMTPDGLPIIGRLPGAPGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPDR 364
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 4-352 2.45e-48

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 166.42  E-value: 2.45e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559    4 DLIIIGSGSVGAAAGYYATRAGLNVLMTDAHMPPHQHGSHHGdTRLIRHAYGEGEK--YVPLVLRAQTLWDELSRHNEDD 81
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARRGLSVTLLERGDDPGSGASGRN-AGLIHPGLRYLEPseLARLALEALDLWEELEEELGID 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559   82 PIFVRSGVINLG-PADSAFLANVAHSAEQWQLNVEKLDAQGIMARWPEirVPDNYIGLFETDSGFLRSELAIKTWIQLAK 160
Cdd:pfam01266  80 CGFRRCGVLVLArDEEEEALEKLLAALRRLGVPAELLDAEELRELEPL--LPGLRGGLFYPDGGHVDPARLLRALARAAE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559  161 EAGCAQLFNCPVTAIRHDDDGVTIETvDGEYQAkkAIVCAGTWVKDLLPELPVQPVRKVFAWYQADGRYSVKNKFPAFTG 240
Cdd:pfam01266 158 ALGVRIIEGTEVTGIEEEGGVWGVVT-TGEADA--VVNAAGAWADLLALPGLRLPVRPVRGQVLVLEPLPEALLILPVPI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559  241 ELPNGDQYYGFPAENDALKIGkhnGGQVIHSADERVPFAEVVsdgSEAFPFLRNVLPGIGCCLYGAACTYDnSPDEDFII 320
Cdd:pfam01266 235 TVDPGRGVYLRPRADGRLLLG---GTDEEDGFDDPTPDPEEI---EELLEAARRLFPALADIERAWAGLRP-LPDGLPII 307

                         330       340       350
                  ....*....|....*....|....*....|..
gi 446795559  321 DTlPGHDNTLLITGLSGHGFKFASVLGEIAAD 352
Cdd:pfam01266 308 GR-PGSPGLYLATGHGGHGLTLAPGIGKLLAE 338
PRK11728 PRK11728
L-2-hydroxyglutarate oxidase;
1-201 1.29e-10

L-2-hydroxyglutarate oxidase;


Pssm-ID: 183292 [Multi-domain]  Cd Length: 393  Bit Score: 62.15  E-value: 1.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559   1 MKYDLIIIGSGSVGAAAGYYATRA--GLNVLMTDAHMPP--HQHGSHHGdtrlIRHAygeGEKYVPLVLRAQtlwdelsr 76
Cdd:PRK11728   1 AMYDFVIIGGGIVGLSTAMQLQERypGARIAVLEKESGParHQTGHNSG----VIHA---GVYYTPGSLKAR-------- 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559  77 hneddpiFVRSGVINL---------------------GPADSAFLANVAHSAEQWQLNVEKLDAQGIMARWPEIR----- 130
Cdd:PRK11728  66 -------FCRRGNEATkafcdqhgipyeecgkllvatSELELERMEALYERARANGIEVERLDAEELREREPNIRglgai 138

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446795559 131 -VPDNYIglfeTDSGFLRSELAiktwiQLAKEAGCAQLFNCPVTAIRHDDDGVTIETVDGEYQAKKAIVCAG 201
Cdd:PRK11728 139 fVPSTGI----VDYRAVAEAMA-----ELIQARGGEIRLGAEVTALDEHANGVVVRTTQGEYEARTLINCAG 201
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
2-230 1.18e-09

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 59.55  E-value: 1.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559   2 KYDLIIIGSGSVGAAAGYYATRAGLNV------------LMTDAHMPPHQ---------HGSHHGDTRLIRhAYGegeky 60
Cdd:COG1231    7 GKDVVIVGAGLAGLAAARELRKAGLDVtvleardrvggrVWTLRFGDDGLyaelgamriPPSHTNLLALAR-ELG----- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559  61 VPLVLRAQTLWDEL-----SRHNEDDPIFVRSGVinlGPADSAFLANVAHSAEQWQLNVEKLDAQ---GIMARWPEIRVP 132
Cdd:COG1231   81 LPLEPFPNENGNALlylggKRVRAGEIAADLRGV---AELLAKLLRALAAALDPWAHPAAELDREslaEWLRRNGASPSA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559 133 DNYIGLFETDSG-----------FLRSELAIKTWIQ--------------LAKEAGCAQLFNCPVTAIRHDDDGVTIETV 187
Cdd:COG1231  158 RRLLGLLGAGEYgadpdelslldLLRYAASAGGGAQqfrivggmdqlpraLAAELGDRIRLGAPVTRIRQDGDGVTVTTD 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446795559 188 DG-EYQAKKAIVCAGTWV--------------KDLLPELPVQPVRKVFAWY-----QADGRYS 230
Cdd:COG1231  238 DGgTVRADAVIVTVPPSVlrriefdpplpaakRAAIQRLPYGAAIKVFLQFdrpfwEEDGLYG 300
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
3-201 3.07e-07

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 51.27  E-value: 3.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559   3 YDLIIIGSGSVGAAAGYYATRAGLNVLMtdahmpphqhgshhgdtrlirhaygegekyvplvlraqtlwdelsrhneddp 82
Cdd:COG0492    1 YDVVIIGAGPAGLTAAIYAARAGLKTLV---------------------------------------------------- 28

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559  83 ifvrsgvinlgpadsaflanvahsaeqwqlnVEKLDAQGIMARWPEIrvpDNYIGLFETDSGFlrsELAiKTWIQLAKEA 162
Cdd:COG0492   29 -------------------------------IEGGEPGGQLATTKEI---ENYPGFPEGISGP---ELA-ERLREQAERF 70

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 446795559 163 GcAQLFNCPVTAIRHDDDGVTIETVDG-EYQAKKAIVCAG 201
Cdd:COG0492   71 G-AEILLEEVTSVDKDDGPFRVTTDDGtEYEAKAVIIATG 109
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 157-223 8.92e-05

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 44.40  E-value: 8.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559  157 QLAKEA-GCAQLFNCPVTAIRHDDDGVTIETVDGE-YQAKKAIVCAG--------------TWVKDLLPELPVQPVRKVF 220
Cdd:pfam01593 211 ALAAQLlGGDVRLNTRVRSIDREGDGVTVTLTDGEvIEADAVIVTVPlgvlkrilftpplpPEKARAIRNLGYGPVNKVH 290


                  ...
gi 446795559  221 AWY 223
Cdd:pfam01593 291 LEF 293
PRK08274 PRK08274
FAD-dependent tricarballylate dehydrogenase TcuA;
1-201 2.20e-04

FAD-dependent tricarballylate dehydrogenase TcuA;


Pssm-ID: 236214 [Multi-domain]  Cd Length: 466  Bit Score: 42.94  E-value: 2.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559   1 MKYDLIIIGSGSVGAAAGYYATRAGLNVLMTDAHMPPHQHG-SHHgdTRLIRHAYGEGEKYVPLVLRAQTLWDELSRHNE 79
Cdd:PRK08274   3 SMVDVLVIGGGNAALCAALAAREAGASVLLLEAAPREWRGGnSRH--TRNLRCMHDAPQDVLVGAYPEEEFWQDLLRVTG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559  80 DDPifvrsgvinlGPADSAFLANVAHSAEQWqlnvekLDAQGIMARWPEIRVpdnyigLFETDSG--FLRSELA-IKTWI 156
Cdd:PRK08274  81 GRT----------DEALARLLIRESSDCRDW------MRKHGVRFQPPLSGA------LHVARTNafFWGGGKAlVNALY 138

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446795559 157 QLAKEAGCAQLFNCPVTAIRHDDDGVTIETV------DGEYQAKKAIVCAG 201
Cdd:PRK08274 139 RSAERLGVEIRYDAPVTALELDDGRFVGARAgsaaggAERIRAKAVVLAAG 189
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 1-35 2.55e-04

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 42.77  E-value: 2.55e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 446795559   1 MKYDLIIIGSGSVGAAAGYYATRAGLNVLMTDAHM 35
Cdd:COG1249    2 KDYDLVVIGAGPGGYVAAIRAAQLGLKVALVEKGR 36
mnmC PRK01747
bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent ...
 4-217 2.72e-04

bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC;


Pssm-ID: 234978 [Multi-domain]  Cd Length: 662  Bit Score: 42.91  E-value: 2.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559   4 DLIIIGSGSVGAAAGYYATRAGLNVLMTDAHMPPHQHGS------------HHGD--TRLIRHAYGEgekyvplvlrAQT 69
Cdd:PRK01747 262 DAAIIGGGIAGAALALALARRGWQVTLYEADEAPAQGASgnrqgalypllsKDDNalSRFFRAAFLF----------ARR 331

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446795559  70 LWDELSRHNEDdpiFVRS--GVINLG-PADSAFLANVAHSAEQWQLNVEKLDAQGIMARwpeIRVPDNYIGLFETDSGFL 146
Cdd:PRK01747 332 FYDALPAAGVA---FDHDwcGVLQLAwDEKSAEKIAKMLALGLPAELARALDAEEAEEL---AGLPVPCGGIFYPQGGWL 405

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446795559 147 R-SELAiKTWIQLAKEAGCAqLFNCPVTAIRHDDDGVTIETVDGE-YQAKKAIVCAGTWVKDLLP--ELPVQPVR 217
Cdd:PRK01747 406 CpAELC-RALLALAGQQLTI-HFGHEVARLEREDDGWQLDFAGGTlASAPVVVLANGHDAARFAQtaHLPLYSVR 478
GG-red-SF TIGR02032
geranylgeranyl reductase family; This model represents a subfamily which includes ...
 3-34 4.21e-04

geranylgeranyl reductase family; This model represents a subfamily which includes geranylgeranyl reductases involved in chlorophyll and bacteriochlorophyll biosynthesis as well as other related enzymes which may also act on geranylgeranyl groups or related substrates. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 273936 [Multi-domain]  Cd Length: 295  Bit Score: 41.54  E-value: 4.21e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 446795559    3 YDLIIIGSGSVGAAAGYYATRAGLNVLMTDAH 34
Cdd:TIGR02032   1 YDVVVVGAGPAGASAAYRLADKGLRVLLLEKK 32
PLN02676 PLN02676
polyamine oxidase
 167-226 7.82e-04

polyamine oxidase


Pssm-ID: 215362 [Multi-domain]  Cd Length: 487  Bit Score: 41.24  E-value: 7.82e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446795559 167 LFNCPVTAIRHDDDGVTIETVDGE-YQAKKAIVCA--GTWVKDLLPELPVQPVRKVFAWYQAD 226
Cdd:PLN02676 248 KLNKVVREISYSKNGVTVKTEDGSvYRAKYVIVSVslGVLQSDLIKFKPPLPDWKIEAIYQFD 310
PRK07608 PRK07608
UbiH/UbiF family hydroxylase;
1-37 5.57e-03

UbiH/UbiF family hydroxylase;


Pssm-ID: 181057 [Multi-domain]  Cd Length: 388  Bit Score: 38.40  E-value: 5.57e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 446795559   1 MKYDLIIIGSGSVGAAAGYYATRAGLNVLMTDAHMPP 37
Cdd:PRK07608   4 MKFDVVVVGGGLVGASLALALAQSGLRVALLAPRAPP 40
TGR TIGR01438
thioredoxin and glutathione reductase selenoprotein; This homodimeric, FAD-containing member ...
 2-40 5.85e-03

thioredoxin and glutathione reductase selenoprotein; This homodimeric, FAD-containing member of the pyridine nucleotide disulfide oxidoreductase family contains a C-terminal motif Cys-SeCys-Gly, where SeCys is selenocysteine encoded by TGA (in some sequence reports interpreted as a stop codon). In some members of this subfamily, Cys-SeCys-Gly is replaced by Cys-Cys-Gly. The reach of the selenium atom at the C-term arm of the protein is proposed to allow broad substrate specificity.


Pssm-ID: 273624 [Multi-domain]  Cd Length: 484  Bit Score: 38.68  E-value: 5.85e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 446795559    2 KYDLIIIGSGSVGAAAGYYATRAGLNVLMTDAHMP-PHQH 40
Cdd:TIGR01438   2 DYDLIVIGGGSGGLAAAKEAAAYGAKVMLLDFVTPtPLGT 41
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 1-32 9.80e-03

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 37.85  E-value: 9.80e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 446795559   1 MKYDLIIIGSGSVGAAAGYYATRAGLNVLMTD 32
Cdd:PRK06292   2 EKYDVIVIGAGPAGYVAARRAAKLGKKVALIE 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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