|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11462 |
PRK11462 |
putative transporter; Provisional |
1-460 |
0e+00 |
|
putative transporter; Provisional
Pssm-ID: 183145 Cd Length: 460 Bit Score: 896.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 1 MKSEVLSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFR 80
Cdd:PRK11462 1 MKSEVLSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 81 PWVLFGALPFGIVCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGM 160
Cdd:PRK11462 81 PWVLFGALPFGIVCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 161 LSTVLMMPLVNLIGGDNKPLGFQGGIAVLSVVAFMMLAFCFFTTKERVEAPPTTTSMREDLRDIWQNDQWRIVGLLTIFN 240
Cdd:PRK11462 161 LSTVLMMPLVNLIGGDNKPLGFQGGIAVLSVVAFMMLAFCFFTTKERVEAPPTTTSMREDLRDIWQNDQWRIVGLLTIFN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 241 ILAVCVLGGAMMYYVTWILGTPEVFVAFLTTYCVGNLIGSALAKPLTDWKCKVTIFWWTNALLAVISLAMFFVPMQASIT 320
Cdd:PRK11462 241 ILAVCVRGGAMMYYVTWILGTPEVFVAFLTTYCVGNLIGSALAKPLTDWKCKVTIFWWTNALLAVISLAMFFVPMQASIT 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 321 MFVFIFVIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEKAQNSA 400
Cdd:PRK11462 321 MFVFIFVIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEKAQNSA 400
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 401 TISIIIALFTIVPAICYLLSAIIAKRYYSLTTHNLKTVMEQLAQGKRRCQQQFTSQEVQN 460
Cdd:PRK11462 401 TISIIIALFTIVPAICYLLSAIIAKRYYSLTTHNLKTVMEQLAQGKRRCQQQFTSQEVQN 460
|
|
| gph |
TIGR00792 |
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ... |
11-445 |
6.27e-174 |
|
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273270 Cd Length: 437 Bit Score: 494.85 E-value: 6.27e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 11 KIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFRPWVLFGALPF 90
Cdd:TIGR00792 1 KLSYGFGDFGNDFIFAIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVDRTRTRWGKFRPWLLIGAIPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 91 GIVCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGMLSTVLMMPLV 170
Cdd:TIGR00792 81 SIVLVLLFTTPDFSGTGKLVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRRFGATLGGLLVAVIVLPLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 171 NLIGGDNKPLGFQGGIAVLSVVAFMMLAFCFFTTKERVEAPPT----TTSMREDLRDIWQNDQWRIVGLLTIFNILAVCV 246
Cdd:TIGR00792 161 SYFGGGDDKFGWFMFALVLALIGVVSLIICFFGTKERYSEIPKniekKLSLKQIFKALFKNDQLLILCLAYLFYNLAFNI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 247 LGGAMMYYVTWILGTPEVFVAFLTTYCVGNLIGsALAKPLTDWKCKVTIFWWTNALLAVISLAMFFVPMQASITMFVFIF 326
Cdd:TIGR00792 241 KNGVQVYYFTYVLGDPELFSYMGSIAIVAGLIG-VLLFPRLVKKFGRKILFAGGILLMVLGYLIFFFAGSNLPLILVLII 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 327 VIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEKAQNSATISIII 406
Cdd:TIGR00792 320 LAGFGQNIVTGLVWALVADTVDYGEWKTGIRAEGLVYSVRTFVRKLGQALAGFFVGLILGIIGYVANAAQSPITLNGIKI 399
|
410 420 430
....*....|....*....|....*....|....*....
gi 446757176 407 aLFTIVPAICYLLSAIIAKRYYSLTTHNLKTVMEQLAQG 445
Cdd:TIGR00792 400 -LMFAVPALFLLLAAIIIGRFYKLTEKKHAEIVEELEQR 437
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
11-431 |
2.13e-134 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 393.89 E-value: 2.13e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 11 KIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFRPWVLFGALPF 90
Cdd:cd17332 1 KIGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGAIPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 91 GIVCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGMLSTVLMMPLV 170
Cdd:cd17332 81 ALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 171 NLIGGDNKPLGFQGGIAVLSVVAFMMLAFCFFTTKERVEAP---PTTTSMREDLRDIWQNDQWRIVGLLTIFNILAVCVL 247
Cdd:cd17332 161 AYFGGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPeeeKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 248 GGAMMYYVTWILGTPEVFVAFLTTYCVGNLIGSALAKPLTDWKCKVTIFWWTNALLAVISLAMFFVPMQASITMFVFIFV 327
Cdd:cd17332 241 NTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 328 IGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEKAQNSATISIIIA 407
Cdd:cd17332 321 AGIGYGGANLLPWAMLADVIDYGELKTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYVANAAAQSASALNGIRL 400
|
410 420
....*....|....*....|....
gi 446757176 408 LFTIVPAICYLLSAIIAKRYYSLT 431
Cdd:cd17332 401 LIAVLPAVLLLLALILMSFYPLDK 424
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
1-446 |
2.54e-120 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 358.83 E-value: 2.54e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 1 MKSEVLSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFR 80
Cdd:COG2211 2 AAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 81 PWVLFGALPFGIVCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGM 160
Cdd:COG2211 82 PWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 161 LSTVLMMPLVNLIGGDNkPLGFQGGIAVLSVVAFMMLAFCFFTTKERVEAPPTTTSMREDLRDIWQNDQWRIVGLLTIFN 240
Cdd:COG2211 162 LASVLPPPLVAAFGGDA-ALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 241 ILAVCVLGGAMMYYVTWILGTPEVFVA-FLTTYCVGNLIGSALAKPLTDWKCKVTIFWWTNALLAVISLAMFFVPMQASI 319
Cdd:COG2211 241 FLALALVAALLLYYFKYVLGLSAALVGlLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLW 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 320 TMFVFIFVIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAeKAQNS 399
Cdd:COG2211 321 LLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAG-AAQSP 399
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 446757176 400 ATISIIIALFTIVPAICYLLSAIIAKRyYSLTTHNLKTVMEQLAQGK 446
Cdd:COG2211 400 SALTGIRLLFFLLPAVLLLLAALLLLF-YPLTRERHAEIRAELAARR 445
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
13-427 |
1.49e-76 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 245.30 E-value: 1.49e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 13 GYGMGDAAsHIIFDNVM-LYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFRPWVLFGALPFG 91
Cdd:pfam13347 1 GYGSGALA-AGIKYAGLaTYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 92 IVCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGMLSTVLMMPLVN 171
Cdd:pfam13347 80 VSFILLFTPPELGRAPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 172 LIGGD-NKPLGFQGGIAVLSVVAFMMLAFCFFTTKERVEAPP-------TTTSMREDLRDIWQNDQWRIVGLLTIFNILA 243
Cdd:pfam13347 160 ILGGTgLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSkedtgqkEAGSLLDMLKEVFRNRAFLILLASFLLAALA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 244 VCVLGGAMMYYVTWILGTPEVFVAFLTTYCVGNLIGSALAKPLTDWKCKVTIFWWTNALLAVISLAMFFVPMQASITMFV 323
Cdd:pfam13347 240 MGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLGPNNTLLFLV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 324 FIFVIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEKAQNSATIS 403
Cdd:pfam13347 320 LYIIIGFGYGSSFFLPWSMLADVVDYGELRTGKRREGTFFAMWSFISKLATGVGLGVSGLLLSAFGYNAGDSVQSPQAVT 399
|
410 420
....*....|....*....|....
gi 446757176 404 IIIALFTIVPAICYLLSAIIAKRY 427
Cdd:pfam13347 400 AIRLLYAVLPAVLFLVALLLLYFY 423
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11462 |
PRK11462 |
putative transporter; Provisional |
1-460 |
0e+00 |
|
putative transporter; Provisional
Pssm-ID: 183145 Cd Length: 460 Bit Score: 896.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 1 MKSEVLSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFR 80
Cdd:PRK11462 1 MKSEVLSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 81 PWVLFGALPFGIVCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGM 160
Cdd:PRK11462 81 PWVLFGALPFGIVCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 161 LSTVLMMPLVNLIGGDNKPLGFQGGIAVLSVVAFMMLAFCFFTTKERVEAPPTTTSMREDLRDIWQNDQWRIVGLLTIFN 240
Cdd:PRK11462 161 LSTVLMMPLVNLIGGDNKPLGFQGGIAVLSVVAFMMLAFCFFTTKERVEAPPTTTSMREDLRDIWQNDQWRIVGLLTIFN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 241 ILAVCVLGGAMMYYVTWILGTPEVFVAFLTTYCVGNLIGSALAKPLTDWKCKVTIFWWTNALLAVISLAMFFVPMQASIT 320
Cdd:PRK11462 241 ILAVCVRGGAMMYYVTWILGTPEVFVAFLTTYCVGNLIGSALAKPLTDWKCKVTIFWWTNALLAVISLAMFFVPMQASIT 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 321 MFVFIFVIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEKAQNSA 400
Cdd:PRK11462 321 MFVFIFVIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEKAQNSA 400
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 401 TISIIIALFTIVPAICYLLSAIIAKRYYSLTTHNLKTVMEQLAQGKRRCQQQFTSQEVQN 460
Cdd:PRK11462 401 TISIIIALFTIVPAICYLLSAIIAKRYYSLTTHNLKTVMEQLAQGKRRCQQQFTSQEVQN 460
|
|
| gph |
TIGR00792 |
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ... |
11-445 |
6.27e-174 |
|
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273270 Cd Length: 437 Bit Score: 494.85 E-value: 6.27e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 11 KIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFRPWVLFGALPF 90
Cdd:TIGR00792 1 KLSYGFGDFGNDFIFAIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVDRTRTRWGKFRPWLLIGAIPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 91 GIVCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGMLSTVLMMPLV 170
Cdd:TIGR00792 81 SIVLVLLFTTPDFSGTGKLVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRRFGATLGGLLVAVIVLPLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 171 NLIGGDNKPLGFQGGIAVLSVVAFMMLAFCFFTTKERVEAPPT----TTSMREDLRDIWQNDQWRIVGLLTIFNILAVCV 246
Cdd:TIGR00792 161 SYFGGGDDKFGWFMFALVLALIGVVSLIICFFGTKERYSEIPKniekKLSLKQIFKALFKNDQLLILCLAYLFYNLAFNI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 247 LGGAMMYYVTWILGTPEVFVAFLTTYCVGNLIGsALAKPLTDWKCKVTIFWWTNALLAVISLAMFFVPMQASITMFVFIF 326
Cdd:TIGR00792 241 KNGVQVYYFTYVLGDPELFSYMGSIAIVAGLIG-VLLFPRLVKKFGRKILFAGGILLMVLGYLIFFFAGSNLPLILVLII 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 327 VIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEKAQNSATISIII 406
Cdd:TIGR00792 320 LAGFGQNIVTGLVWALVADTVDYGEWKTGIRAEGLVYSVRTFVRKLGQALAGFFVGLILGIIGYVANAAQSPITLNGIKI 399
|
410 420 430
....*....|....*....|....*....|....*....
gi 446757176 407 aLFTIVPAICYLLSAIIAKRYYSLTTHNLKTVMEQLAQG 445
Cdd:TIGR00792 400 -LMFAVPALFLLLAAIIIGRFYKLTEKKHAEIVEELEQR 437
|
|
| PRK09669 |
PRK09669 |
putative symporter YagG; Provisional |
1-444 |
2.12e-138 |
|
putative symporter YagG; Provisional
Pssm-ID: 236610 Cd Length: 444 Bit Score: 404.88 E-value: 2.12e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 1 MKSEVLSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFR 80
Cdd:PRK09669 1 MNTSQLTTKDKIGYGLGDTACNLVWQTVMLFLAYFYTDVFGLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTRTRHGQFR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 81 PWVLFGALPFGIVCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGM 160
Cdd:PRK09669 81 PYLLWFAIPFGVVCLLTFYTPDFGATGKIIYACVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSWRFALSFIGGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 161 LSTVLMMPLVNLIGGDNKPLGFQGGIAVLSVVAFMMLAFCFFTTKERVEAPP-TTTSMREDLRDIWQNDQWRIVGLLTIF 239
Cdd:PRK09669 161 IVSVIALPLVDILGKGDEQKGYFYAMMVMGLLGVVLFFCCFFMTKERYTPEVdNSSSVWKDLKLLLGNSQWRIMFIFNVV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 240 NILAVCVLGGAMMYYVTWILGTPEVFVAFLTTYCVGNLIGSALAKPLTDWKCKVTIFWWTNALLAVISLAMFFVPMQASI 319
Cdd:PRK09669 241 LLTAVVTRGGATLYYVNYVLLRPDLATLFLVTGMIAGLFGALLSERLLGKFDRVRAFKWTIVAFVILSALIFFIPPSNVW 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 320 TMFVFIFVIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEKAQNS 399
Cdd:PRK09669 321 LIFALNILFNFIQNLTTPLQWSMFSDVVDYEEKRSGRRLDGLVFSTNLFAIKLGLAIGGAVVGWILAWVDYVGGAAVQSA 400
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 446757176 400 ATISIIIALFTIVPAICYLLSAIIAKRyYSLTTHNLKTVMEQLAQ 444
Cdd:PRK09669 401 SVLTTINLLFTVIPGVLFAGMAIILNF-YKLNDARVEAIAQELVK 444
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
11-431 |
2.13e-134 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 393.89 E-value: 2.13e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 11 KIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFRPWVLFGALPF 90
Cdd:cd17332 1 KIGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGAIPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 91 GIVCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGMLSTVLMMPLV 170
Cdd:cd17332 81 ALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 171 NLIGGDNKPLGFQGGIAVLSVVAFMMLAFCFFTTKERVEAP---PTTTSMREDLRDIWQNDQWRIVGLLTIFNILAVCVL 247
Cdd:cd17332 161 AYFGGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPeeeKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 248 GGAMMYYVTWILGTPEVFVAFLTTYCVGNLIGSALAKPLTDWKCKVTIFWWTNALLAVISLAMFFVPMQASITMFVFIFV 327
Cdd:cd17332 241 NTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 328 IGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEKAQNSATISIIIA 407
Cdd:cd17332 321 AGIGYGGANLLPWAMLADVIDYGELKTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYVANAAAQSASALNGIRL 400
|
410 420
....*....|....*....|....
gi 446757176 408 LFTIVPAICYLLSAIIAKRYYSLT 431
Cdd:cd17332 401 LIAVLPAVLLLLALILMSFYPLDK 424
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
1-446 |
2.54e-120 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 358.83 E-value: 2.54e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 1 MKSEVLSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFR 80
Cdd:COG2211 2 AAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 81 PWVLFGALPFGIVCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGM 160
Cdd:COG2211 82 PWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 161 LSTVLMMPLVNLIGGDNkPLGFQGGIAVLSVVAFMMLAFCFFTTKERVEAPPTTTSMREDLRDIWQNDQWRIVGLLTIFN 240
Cdd:COG2211 162 LASVLPPPLVAAFGGDA-ALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 241 ILAVCVLGGAMMYYVTWILGTPEVFVA-FLTTYCVGNLIGSALAKPLTDWKCKVTIFWWTNALLAVISLAMFFVPMQASI 319
Cdd:COG2211 241 FLALALVAALLLYYFKYVLGLSAALVGlLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLW 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 320 TMFVFIFVIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAeKAQNS 399
Cdd:COG2211 321 LLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAG-AAQSP 399
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 446757176 400 ATISIIIALFTIVPAICYLLSAIIAKRyYSLTTHNLKTVMEQLAQGK 446
Cdd:COG2211 400 SALTGIRLLFFLLPAVLLLLAALLLLF-YPLTRERHAEIRAELAARR 445
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
13-427 |
1.49e-76 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 245.30 E-value: 1.49e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 13 GYGMGDAAsHIIFDNVM-LYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFRPWVLFGALPFG 91
Cdd:pfam13347 1 GYGSGALA-AGIKYAGLaTYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 92 IVCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGMLSTVLMMPLVN 171
Cdd:pfam13347 80 VSFILLFTPPELGRAPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 172 LIGGD-NKPLGFQGGIAVLSVVAFMMLAFCFFTTKERVEAPP-------TTTSMREDLRDIWQNDQWRIVGLLTIFNILA 243
Cdd:pfam13347 160 ILGGTgLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSkedtgqkEAGSLLDMLKEVFRNRAFLILLASFLLAALA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 244 VCVLGGAMMYYVTWILGTPEVFVAFLTTYCVGNLIGSALAKPLTDWKCKVTIFWWTNALLAVISLAMFFVPMQASITMFV 323
Cdd:pfam13347 240 MGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLGPNNTLLFLV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 324 FIFVIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEKAQNSATIS 403
Cdd:pfam13347 320 LYIIIGFGYGSSFFLPWSMLADVVDYGELRTGKRREGTFFAMWSFISKLATGVGLGVSGLLLSAFGYNAGDSVQSPQAVT 399
|
410 420
....*....|....*....|....
gi 446757176 404 IIIALFTIVPAICYLLSAIIAKRY 427
Cdd:pfam13347 400 AIRLLYAVLPAVLFLVALLLLYFY 423
|
|
| PRK10429 |
PRK10429 |
melibiose:sodium transporter MelB; |
6-459 |
2.51e-68 |
|
melibiose:sodium transporter MelB;
Pssm-ID: 182453 Cd Length: 473 Bit Score: 225.36 E-value: 2.51e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 6 LSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFRPWVLF 85
Cdd:PRK10429 3 ISMTTKLSYGFGAFGKDFAIGIVYMYLMYYYTDVVGLSVGLVGTLFLVARIWDAINDPIMGWIVNNTRSRWGKFKPWILI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 86 GALPFGIVCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGMLSTVL 165
Cdd:PRK10429 83 GTLANSVVLFLLFSAHLFEGTAQYVFVCVTYILWGMTYTIMDIPFWSLVPTLTLDKREREQLVPYPRFFASLAGFVTAGF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 166 MMPLVNLIGGDNKPLGFQGGIAVLSVVAFMMLAFCFFTTKERVEAP--PTTTSMREDLRDIW----QNDQWR-IVGLLTI 238
Cdd:PRK10429 163 TLPFVNYVGGGDRGFGFQMFTLVLIAFFIVSTIITLRNVHEVYSSDnqVSAEGSHLTLKDIValiyKNDQLScLLGMALA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 239 FNILAVCVlGGAMMYYVTWILGTPEVFVAFLTTYCVGNLIGSALAKPLTDWKCKvTIFWWTNALLAVISLAMFFVPMQAS 318
Cdd:PRK10429 243 YNIASNII-NGFAIYYFTYVIGDADLFPYYLSYAGAANLVTLILFPRLVKSLSR-RILWAGASIFPVLSCGVLLLMGLAA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 319 ITMFVFIFVIGVLHQLVTPIQW----VMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAE 394
Cdd:PRK10429 321 PHNALLIVIAGILLNIGTALFWvlqvIMVADTVDYGEYKLGIRCESIAYSVQTMVVKGGSAFAAFFIGVVLGLIGYVPNV 400
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446757176 395 kAQNSATISIIIALFTIVPAICYLLSAIIAKRYYSLTTHNLKTVMEQLAQGKRRCQQQFTSQEVQ 459
Cdd:PRK10429 401 -EQSAQTLLGMQFIMIGLPTLFFMITLVLYFRYYRLNGDFLRRIQIHLLDKYRKVPPEPVHAEIP 464
|
|
| PRK09848 |
PRK09848 |
glucuronide transporter; Provisional |
6-427 |
2.10e-64 |
|
glucuronide transporter; Provisional
Pssm-ID: 182109 [Multi-domain] Cd Length: 448 Bit Score: 214.26 E-value: 2.10e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 6 LSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFRPWVLF 85
Cdd:PRK09848 5 LSWRTIVGYSLGDVANNFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRVFDAFADVFAGRVVDSVNTRWGKFRPFLLF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 86 GALPFGIVCVLAYSTP-DLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGMLSTV 164
Cdd:PRK09848 85 GTAPLMIFSVLVFWVPtDWSHSSKVVYAYLTYMGLGLCYSLVNIPYGSLATAMTQQPQSRARLGAARGIAASLTFVCLAF 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 165 LMMPLVNLIGGDNKPLGFQGGIAVLSVVAFMMLAFCFFTTKERVEAPPTTTSMREDLRDIWQNDQwrivglLTIFNILAV 244
Cdd:PRK09848 165 LIGPSIKNSSPEEMVSVYHFWTIVLAIAGMVLYFICFKSTRENVVRIVAQPSLKISLQTLKRNRP------LFMLCIGAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 245 CVLGGAM------MYYVTWILGTPEVFVAF-LTTYCVGNLIGSALAKPLTDWKCKVTIFWWTNALLAVISLAMFFVPMQA 317
Cdd:PRK09848 239 CVLISTFavsassLFYVRYVLNDTGLFTVLvLVQNLVGTVASAPLVPGMVARIGKKNTFLIGALLGTCGYLLFFWVSVWS 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 318 SITMFVFIFVIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEKAQ 397
Cdd:PRK09848 319 LPVALVALAIASIGQGVTMTVMWALEADTVEYGEYLTGVRIEGLTYSLFSFTRKCGQAIGGSIPAFILGLSGYIANQVQT 398
|
410 420 430
....*....|....*....|....*....|
gi 446757176 398 NSATISIIIALfTIVPAICYLLSAIIAKRY 427
Cdd:PRK09848 399 PEVIMGIRTSI-ALVPCGFMLLAFVIIWFY 427
|
|
| MFS_MFSD2 |
cd17392 |
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator ... |
11-430 |
1.98e-11 |
|
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator superfamily domain-containing protein 2 (MFSD2) subfamily is composed of two vertebrate members, MFSD2A amd MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD2 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340950 Cd Length: 446 Bit Score: 65.57 E-value: 1.98e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 11 KIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRT-RSRWGKFRPWVLFgALP 89
Cdd:cd17392 1 KLCYAIGGAPYQMTSSATGFFLQIFLLDVAQMGAFSVSLILFVGRVWDAVTDPLVGYFISRSqRTGIGRLMPWIVF-STP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 90 FGIVC-VLAYSTPDLSMnGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGMLSTVLMMP 168
Cdd:cd17392 80 LIILAyFFLWFLPPFTS-LSGLWYLTFYCLFETFMTCFHVPYSALTMFLGGCQRERDSATAYRMTVEVFGTLMGATIQGQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 169 LVnliGGDNKPL-----------------------GFQGGIAVLSVVAFMMLAFCFFTTKERVEapPTTTSMRED----- 220
Cdd:cd17392 159 IV---GVAHRPRrqdctatpgtsdhpvtvlpntrrAYLIAALVVVVLYFVCCSILFLGVKEQPD--PLSPASGPGlsyla 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 221 -LRDIWQNDQWRIVGLLTIFNILAVCVLGGAMMYYVTWILGTPEVFVAFLTTYcvgnLIGSALAKPLTDWKC-----KVT 294
Cdd:cd17392 234 gLKLVTGHPPYLKLVIGFLFSSLAFQMEQGNFVLFCTHAAGLGDHFQHLVLAI----LVSATLSIPLWQWVLqrrgkKTT 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 295 IFWwtnALLAVISLAMFFVPMQASITMFVFI-FVIGVLHQLVTPIQWVMMSDTVDYGEWCN--GKRLTGISFAGTLFVLK 371
Cdd:cd17392 310 SFI---GISAMVPFLILLALVPSNLPVAYVVaVVSGVSLAALFLLPWSMLPDVVDDFQLKNphCPGLEPIFYSCYVFFTK 386
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 446757176 372 LGLAFGGALIGWMLAYGGYDAAEKAQNSATISIIIALFTIVPaICYLLSAIIAKRYYSL 430
Cdd:cd17392 387 LGGGLSLGISTLSLHFSGYKAGACKQPEEVVVTLKVLIAPVP-ICLILAGLVLFYVYPI 444
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
36-389 |
1.23e-10 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 62.83 E-value: 1.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 36 YTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRsrwgkFRPWVLFGALPFGIVCVLAYSTPDLSMngkmiyAAIT 115
Cdd:cd06174 22 LLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFG-----RRPVLLLGLLLFALGALLFAFAPSFWL------LLLG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 116 YTLLTLLYTVVNIPYCALGGVITnDPTQRISLQSWRFVLATAGGMLSTVLMMPLVNLIGGDNKplGFQGGIAVLSVVAFM 195
Cdd:cd06174 91 RFLLGLGSGLIDPAVLALIADLF-PERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWR--AVFLIAAALALLAAI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 196 MLAFCFFTTKERVEAPPTTTSMREDLRDIWQNDQWRIVGLLTIFNILAVCVLGGAMMYYVTWIL----GTPEVFVAFLTT 271
Cdd:cd06174 168 LLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLdlggLSVAVAGLLLSL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 272 YCVGNLIGSALAKPLTDWKCKVTIFWWTNALLAVISLAMFFVPMQASItMFVFIFVIGVLHQLVTPIQWVMMSDTVDyge 351
Cdd:cd06174 248 FGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLL-LLLLLLLLGFGLGGLLPLSFALIAELFP--- 323
|
330 340 350
....*....|....*....|....*....|....*...
gi 446757176 352 wcngKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGG 389
Cdd:cd06174 324 ----PEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
|
|
| MFS_NLS1_MFSD2A |
cd17451 |
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of ... |
11-348 |
3.26e-10 |
|
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of transporters; Sodium-dependent lysophosphatidylcholine (LPC) symporter 1 (NLS1) is also called major facilitator superfamily domain-containing protein 2A (MFSD2A). NLS1/MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. It also transports the essential omega-3 fatty acid docosahexaenoic acid (DHA), which is essential for normal brain growth and cognitive function, in the form of LPC into the brain across the blood-brain barrier. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. NLS1/MFSD2A belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341009 Cd Length: 419 Bit Score: 61.75 E-value: 3.26e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 11 KIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTR-SRWGKFRPWVLFgALP 89
Cdd:cd17451 1 KLCYAIGGAPYQITGCALGFFLQIYLLDVAQLDPFYASIILFVGRAWDAITDPTVGFFVSKSPwTRFGRLMPWIIF-STP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 90 FGIVC-VLAYSTPDLSmNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGMLSTVLMMP 168
Cdd:cd17451 80 FAVLSyFLIWFVPDFS-QGKVMWYLLFYCLFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTVLGTAIQGQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 169 LVNLIggdnkplGFQGGIAVLSVVAFMMLAFCFFTTKERVEA----PPTTTSMREDLRDIWQNDQWRIVGLLTIFNILAV 244
Cdd:cd17451 159 IVGMA-------AYMIAAGVICAIYVLCAIILFLGVREQREPcelkSQKPVSFFKGLKLVMSHGPYIKLITGFLFTSLAF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 245 CVLGGAMMYYVTWILGTPEVFVAFLTTYcvgnLIGSALAKPLtdWKCKVTIFWWTNALLAVISLAMFF----VPMQAS-I 319
Cdd:cd17451 232 MLLEGNFALFCTYTLGFRNDFQNILLVI----MLSATLTIPF--WQWFLTRFGKKTAVYIGISSAVPFlilvVLVESNlI 305
|
330 340
....*....|....*....|....*....
gi 446757176 320 TMFVFIFVIGVLHQLVTPIQWVMMSDTVD 348
Cdd:cd17451 306 VTYVVSVAAGVSVAAAFLLPWSMLPDVVD 334
|
|
| MFS_MFSD2B |
cd17452 |
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily ... |
11-431 |
3.56e-09 |
|
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily domain-containing protein 2B (MFSD2B) is closely related to MFSD2A, and their conserved genomic structure suggests that they are derived from the duplication of an ancestral gene. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer identified MFSD2B as a potential risk or protect factor in the prognosis of lung adenocarcinoma. MFSD2B belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341010 Cd Length: 416 Bit Score: 58.68 E-value: 3.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 11 KIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLAdrTRSRW---GKFRPWVLfGA 87
Cdd:cd17452 1 KLCYAIGGAPNQVAGSATAFFLQIYLLDIAQITPFQASLVLFVGKAWGAATDPVVGFFI--SKSKWtkiGRLMPWML-GC 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 88 LPFGIVC-VLAYSTPDLSmNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGMLSTVLM 166
Cdd:cd17452 78 TPFIVVSyFFLWFVPPFT-TGRFLWYLTFYCLFQALATCFHVPYSALTMFLSTDQRERDSATAYRMTVEVLGTLVGAAVQ 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 167 MPLVnliggdnkPLGFQGGIAVLSVVAFMMLAFCFFTTKERvEAPPTTTSMR-----EDLRDIWQNDQWRIVGLLTIFNI 241
Cdd:cd17452 157 GQIV--------ASAYMIAAGVIGGLYLLCISVLFLGVKER-DDPYAPKSGKaipffKGLSLTMRHGPYLKLTASFLFIS 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 242 LAVCVLGGAMMYYVTWILGTPEVFVAFLTTYcvgnLIGSALAKPLTDWkckVTIFWWTNALLAVISLAMFFVPMQASITM 321
Cdd:cd17452 228 AAVQLEQSNFVLFCTHAVDLHDHFQNLVLTI----LVSAVVSIPFWQW---FLQRFGKKAAACGISWMIPFAIMLVTIPN 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 322 FVFIFVIGVLHQLVTP----IQWVMMSDTVDYGEWCN--GKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEK 395
Cdd:cd17452 301 LIVAYVVAFVSGLSIAasllLPWSMLPDVVDDFRLQNphGKGLETIFYSSYVFFTKLSAGIALGISTLSLEFAGYETGAC 380
|
410 420 430
....*....|....*....|....*....|....*.
gi 446757176 396 AQNSATISIIIALFTIVPAICYLLSAIIAkRYYSLT 431
Cdd:cd17452 381 KQPESVVLTLKLLIGAAPTCMILIGLCIL-MFYPIT 415
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
154-347 |
7.32e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 48.05 E-value: 7.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 154 LATAGGMLSTVLMMPLVNLIGGdnkPLGFQGGIAVLSVVAFMMLAFCFFTTKERveAPPTTTSMREDLRDIWQNDQWRIV 233
Cdd:COG2814 138 LLGAGLGLGPALGPLLGGLLAD---LFGWRWVFLVNAVLALLALLLLLRLLPES--RPAARARLRGSLRELLRRPRLLLL 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 234 GLLTIFNILAVCVLGGAMMYYVTWILG-TPEVFVAFLTTYCVGNLIGSALAKPLTDWKCKVTIFWWTNALLAVISLAMFF 312
Cdd:COG2814 213 LLLAFLLGFGFFALFTYLPLYLQEVLGlSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL 292
|
170 180 190
....*....|....*....|....*....|....*
gi 446757176 313 VPmqASITMFVFIFVIGVLHQLVTPIQWVMMSDTV 347
Cdd:COG2814 293 AG--SLWLLLLALFLLGFGFGLLFPLLQALVAELA 325
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
235-419 |
2.56e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.40 E-value: 2.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 235 LLTIFNILAVCVLGGAMMYYVTWI---LGTPEVFVAFLTT-YCVGNLIGSALAKPLTDW--KCKVTIFWWTNALLAVISL 308
Cdd:COG2271 184 LLALAYFLVYFALYGFLTWLPTYLvevRGLSLAQAGLLLSlPFLAGIVGSLLGGWLSDRlgRRRKLVLAIGLLLAALALL 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 309 AMFFVPmqASITMFVFIFVIGVLHQLVTPIQWVMMSDTVdygewcnGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYG 388
Cdd:COG2271 264 LLALLP--SPALAIALLFLAGFGLGGAFGLLWALAAELF-------PKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT 334
|
170 180 190
....*....|....*....|....*....|.
gi 446757176 389 GYDAAekaqnsatiSIIIALFTIVPAICYLL 419
Cdd:COG2271 335 GYQAA---------FLLLAALALLAALLALL 356
|
|
| MFS_FBT |
cd17484 |
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ... |
139-308 |
6.59e-05 |
|
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341037 [Multi-domain] Cd Length: 399 Bit Score: 44.91 E-value: 6.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 139 NDPTQRISLQSWRFVLATAGGMLSTVLMMPLVNLiggdnkpLGFQGGIAVLSVVAFMMLAFCFFTTKERVEAPPTTTSMR 218
Cdd:cd17484 124 APQSLAGDLQSLCWGSSAIGGIVGSYFSGYLLEL-------LGPRTVFAVTSFFPLLLLIVAFFVKEERVPPHRTKENFD 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 219 EDLRDIWQNDQWRIVGLLTIFNILAVCV--LGGAMMYYVTWILGTPEVFVAFL-TTYCVGNLIGSAL-AKPLTDWKCKvT 294
Cdd:cd17484 197 EQLKALWETVKQPSIWLPALFIFLYQATpsSGSAMFYFMTNELGFSPEFLGRLrVIGSIASLLGVLLyNRFLKHVPFR-K 275
|
170
....*....|....
gi 446757176 295 IFWWTNALLAVISL 308
Cdd:cd17484 276 IFFWTTVLLVLLGL 289
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
154-393 |
6.71e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 41.79 E-value: 6.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 154 LATAGGMLSTVLMMPLVNLIGGDnkpLGFQGGIAVLSVVAF-MMLAFCFFTTKERVEAPPTTTSMREDLRDIWQNDQWRI 232
Cdd:COG2223 133 LAAGGGNLGAAVAAFLAPLLIAA---FGWRNAFLILGILLLvVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRFWL 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 233 VGLLTIFNILAVCVLGGAMMYYVTWILGTPEVFVAFLTTYC-VGNLIGSALAKPLTDWKCKVTIFWWTNALLAVISLAMF 311
Cdd:COG2223 210 LSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFaLLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLA 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 312 FVPMQASITMFVFiFVIGVLHQLVTPIQWVMMSDTvdygewcNGKRLTGISFAGTLFVLKLGLAFGGALIGWML-AYGGY 390
Cdd:COG2223 290 LALGSLWLFLVLF-LLLGLALGGGNGAVFALVPDI-------FPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLdATGSY 361
|
...
gi 446757176 391 DAA 393
Cdd:COG2223 362 TAA 364
|
|
| BT1 |
pfam03092 |
BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative ... |
141-260 |
1.12e-03 |
|
BT1 family; Members of this family are transmembrane proteins. Several are Leishmania putative proteins that are thought to be pteridine transporters. One such protein Swiss:Q25272, previously termed (and is still annotated as) ORFG, was shown to encode a biopterin transport protein using null mutants, thus being subsequently renamed BT1. The significant similarity of ORFG/BT1 to Trypanosoma brucei ESAG10 (a putative transmembrane protein and another member of this family) was previously noted. This family also contains five putative Arabidopsis thaliana proteins of unknown function. In addition, it also contains two predicted prokaryotic proteins (from the cyanobacteria Synechocystis and Synechococcus).
Pssm-ID: 308617 Cd Length: 432 Bit Score: 41.18 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 141 PTQRISLQSWRFVLATAGGMLSTVLMMPLVNLIGGdnkplgfQGGIAVLSVVAFMMLAFCFFTTKER--VEAPPTTTSM- 217
Cdd:pfam03092 119 PTPGPSLQSWIWGCSAVGGIIGSVLSGPLLDTFKP-------QISFFVTAALQLLTCVVALLIKESSlgLPAKHEPKRPv 191
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 446757176 218 ----------REDLRDIWQNDQWRIVGLLTIF-----NILAVCVLGGAMMYYVTWILG 260
Cdd:pfam03092 192 pclfglfemnREVISRNWKAFRYSEILTPTLFamlsqAILPLVIAKANVFFYTTNVLG 249
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
19-347 |
1.30e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.86 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 19 AASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRtrsrWGKfRPWVLFGALPFGIVCVLAY 98
Cdd:pfam07690 6 FLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR----FGR-RRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 99 STPDLSMngkMIYAAITYTLLTLLYTVVNIPYCALggviTNDPTQRISLQSWRFVLATAGGMLSTVLMMPLVNLiggdnk 178
Cdd:pfam07690 81 FASSLWL---LLVLRVLQGLGAGALFPAALALIAD----WFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL------ 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 179 pLGFQGGIAVLSVVAFMMLAFCFFTTKERVEAPPTTTSMREDLRDIWQNDQWRIVGLLTIFNILAVCVLGGAMMYYVTWI 258
Cdd:pfam07690 148 -FGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 259 LG----TPEVFVAFLTTYCVGNLIGSALAKPLTDWKCKVTIFWWTNALLAVISLAMFFVPMQASITMF-VFIFVIGVLHQ 333
Cdd:pfam07690 227 QEvlglSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLlLALLLLGFGFG 306
|
330
....*....|....
gi 446757176 334 LVTPIQWVMMSDTV 347
Cdd:pfam07690 307 LVFPALNALVSDLA 320
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
154-418 |
3.36e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 39.45 E-value: 3.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 154 LATAGGMLSTVLMMPLVNLIGGDnkpLGFQGGIAVLSVVAFMMLAFCFFTTKERVEAPPTTTSMREDLRDIWQNDQWRIV 233
Cdd:cd17324 127 LVFSGLTLGLVLGRPLGGLLGQL---LGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNPRLRLA 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 234 GLLTIFNILAVcvlgGAMMYYVTWILGT-----PEVFVAFLTTYCVGNLIGSALAKPLTDWKCKVTIFWWTnALLAVISL 308
Cdd:cd17324 204 YLITFLLFGGF----FALYTYLAPFLTDvpgfsSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIAL-LLLAAALL 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 309 AMFFVPmQASITMFVFIFVIGVLHQLVTPIQWVMMSDTvdygewcnGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYG 388
Cdd:cd17324 279 LLTLLG-PSPLLLLVGLVLWGLGFFAAHSALQTRVLRL--------APEARGLASSLYLAAYNLGGALGAALGGLVLDHG 349
|
250 260 270
....*....|....*....|....*....|
gi 446757176 389 GYdaaekaqnsATISIIIALFTIVPAICYL 418
Cdd:cd17324 350 GW---------AGVGWVGAALLLLALLLAL 370
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
180-412 |
4.41e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.14 E-value: 4.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 180 LGFQGGIAVLSVVAFMMLAFCFFTTKERVEAPPT-----TTSMREDLRDIWQNDQWRIVGLLTIFNILAVCVLGGAMMYY 254
Cdd:cd06173 155 LGPGGAFAINALSFLLSALLLLFIRRPPPAAPGEsssllLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLL 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 255 VTWILG-TPEVFVAFLTTYCVGNLIGSALAKPLTDWKCKVTIFWWTNALLAVISLAMFFVPMQasITMFVFIFVIGVLHQ 333
Cdd:cd06173 235 AKEVLGgGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSL--WLLLAALFLLGLAGG 312
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446757176 334 LVTPIQWVMMSDTVDygewcngKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAekAQNSATISIIIALFTIV 412
Cdd:cd06173 313 LFNVPLNTLLQLRVP-------DELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAV--FLLAGALLLLAALLLLL 382
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
180-412 |
9.11e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 38.33 E-value: 9.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 180 LGFQGGIAVLSVVAFMMLAFCFFTTKERVEAPPTTTSMREDLRDIWQND--QWRIVGLLTIFNILAVCV--LGGAMMYYV 255
Cdd:cd17325 147 LGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLlrDRRLLALFLAIFVLAFAFgaLEPFLPLYA 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 256 TWILG-TPEVFVAFLTTYCVGNLIGSALAKPLTDWKCKVTIFwwtNALLAVISLAMFFVPMQASI-TMFVFIFVIGVLHQ 333
Cdd:cd17325 227 AELGGlSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLI---LIGLLLSAVALLLLPLATSFwLLLLLLALLGLGLG 303
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446757176 334 LVTPIQWVMMSDTVDygewcngKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEKAqnSATISIIIALFTIV 412
Cdd:cd17325 304 LVFPATLALLADIVP-------PEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLA--AAALLLLAAVLFLL 373
|
|
| MFS_MFSD12 |
cd17491 |
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily ... |
11-96 |
9.89e-03 |
|
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain-containing protein 12 (MFSD12) protein subfamily includes a group of uncharacterized proteins similar to human MFSD2. MFSD2 is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD12 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341044 Cd Length: 438 Bit Score: 38.01 E-value: 9.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446757176 11 KIGYGMGdaasHIIFDnvmLY--MMFFYTDIF-----GIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRW--GKFRP 81
Cdd:cd17491 1 RIAYGVG----HVLND---LCasMWFTYLLVYfhlvlGFSSALAGILLLIGQVADAISTPLVGYESDRTNGCGkyGRRKS 73
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90
....*....|....*
gi 446757176 82 WVLFGAlpfgiVCVL 96
Cdd:cd17491 74 WHLIGT-----ICVL 83
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