NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446755183|ref|WP_000832439|]
View 

MULTISPECIES: TonB-dependent siderophore receptor [Escherichia]

Protein Classification

TonB-dependent receptor plug domain-containing protein( domain architecture ID 11469150)

TonB-dependent receptor plug domain-containing protein may act as a TonB-dependent siderophore receptor, a channel to allow import of iron-siderophore complexes; similar to Escherichia coli ferrienterobactin receptor, which is involved in the initial step of iron uptake by binding ferrienterobactin

Gene Ontology:  GO:0015891|GO:0055085|GO:0015267|GO:0016020|GO:0009279
PubMed:  12409204|32355044|9886293|15111112

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 31-610 3.58e-26

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


:

Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 114.18  E-value: 3.58e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183  31 EEMTVYAP--------VPVPVngnTHYTSESIERLPTGNgnISDLLRTNPAVRMDSTQSTSLNQGdirpekISIHGASPY 102
Cdd:COG4771   28 EEVVVTATrteqslsdAPASV---SVITAEEIEKLGATD--LADALRLLPGVSVTRSGGRGGSSG------ISIRGLGGD 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 103 QNAYLIDGIsatnnlnPANESDASSATNISgmsqgyYLDVSLLDNVTLYDSFVPVEFG-RFNGGVIDAKIKRFNADDskv 181
Cdd:COG4771   97 RVLVLIDGV-------PVNNPALGGGGDLS------YIPPDDIERIEVIRGPASALYGsDAIGGVINIITKKPTDEL--- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 182 klgyrttrsdwltshidennksafnQGSSGSTYYSPDFKKNFYTLSFNQElADNFGVTAGLSRRQSDITRaDYvsNDGIV 261
Cdd:COG4771  161 -------------------------EGSVSLGYGSNGNGTYSGSLSLGGP-GDKLSFLLSGSYRDRDGYL-DY--RNGGF 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 262 AGRAQYKNviDTALSKFTWFASDRFTHDLTLKYTGSSRDYNTSTFPQSDREmGNKSYGLAWDMDTQLAWAKLRTTVGWDH 341
Cdd:COG4771  212 VGNSGYER--YNLNAKLGYRLSDNHRLSLSGGYSRQDRDGGPPTLGDTEIS-SDNAGDRDTTTDRGNYSLRYNGDLGDNL 288

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 342 ISD--YTRHDHDIWYTELSCTYGDITgrctrgglghiSQAVDNYTFKTRLDWQkfavGNVSHQPYFGAEYIYSDawterh 419
Cdd:COG4771  289 DLSlyYSRTDRDSTNGSLGGSTGSFS-----------DSDDTTYGLELDLTYP----LGGNHTLTLGAEYRYDD------ 347

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 420 NQSESYVINAAGKKTNHTIYhkgkgslGIDNYTLymadhisWRNVSLMPGVRYDYDNYLSN---HNISPRFMTEWDIfaD 496
Cdd:COG4771  348 LDSSSFLGGADASRDTYGLF-------AQDEWKL-------TDKLTLTAGLRYDYYSTFGAsnyTAFSPRLGLRYDL--S 411

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 497 QTSMITAGYNRYY-GGNILDMGLrDIRNSWTESVSGNktltryQNLKTPYNDELAMGLQQKIGKN-VIARANYVYREAHD 574
Cdd:COG4771  412 DNLTLRASYGRGFrAPSLAELYG-SGTGTPGRYVLGN------PDLKPETSDNYELGLEYRLGNGgLSLSLTGFYTDIKD 484

                        570       580       590
                 ....*....|....*....|....*....|....*.
gi 446755183 575 QIskSSRTDSATKTTITEYNNDGKTKTHSFNLSFEL 610
Cdd:COG4771  485 LI--VLVPVGPGPGDVLQYENVGKARTYGLELELKY 518
 
Name Accession Description Interval E-value
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 31-610 3.58e-26

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 114.18  E-value: 3.58e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183  31 EEMTVYAP--------VPVPVngnTHYTSESIERLPTGNgnISDLLRTNPAVRMDSTQSTSLNQGdirpekISIHGASPY 102
Cdd:COG4771   28 EEVVVTATrteqslsdAPASV---SVITAEEIEKLGATD--LADALRLLPGVSVTRSGGRGGSSG------ISIRGLGGD 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 103 QNAYLIDGIsatnnlnPANESDASSATNISgmsqgyYLDVSLLDNVTLYDSFVPVEFG-RFNGGVIDAKIKRFNADDskv 181
Cdd:COG4771   97 RVLVLIDGV-------PVNNPALGGGGDLS------YIPPDDIERIEVIRGPASALYGsDAIGGVINIITKKPTDEL--- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 182 klgyrttrsdwltshidennksafnQGSSGSTYYSPDFKKNFYTLSFNQElADNFGVTAGLSRRQSDITRaDYvsNDGIV 261
Cdd:COG4771  161 -------------------------EGSVSLGYGSNGNGTYSGSLSLGGP-GDKLSFLLSGSYRDRDGYL-DY--RNGGF 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 262 AGRAQYKNviDTALSKFTWFASDRFTHDLTLKYTGSSRDYNTSTFPQSDREmGNKSYGLAWDMDTQLAWAKLRTTVGWDH 341
Cdd:COG4771  212 VGNSGYER--YNLNAKLGYRLSDNHRLSLSGGYSRQDRDGGPPTLGDTEIS-SDNAGDRDTTTDRGNYSLRYNGDLGDNL 288

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 342 ISD--YTRHDHDIWYTELSCTYGDITgrctrgglghiSQAVDNYTFKTRLDWQkfavGNVSHQPYFGAEYIYSDawterh 419
Cdd:COG4771  289 DLSlyYSRTDRDSTNGSLGGSTGSFS-----------DSDDTTYGLELDLTYP----LGGNHTLTLGAEYRYDD------ 347

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 420 NQSESYVINAAGKKTNHTIYhkgkgslGIDNYTLymadhisWRNVSLMPGVRYDYDNYLSN---HNISPRFMTEWDIfaD 496
Cdd:COG4771  348 LDSSSFLGGADASRDTYGLF-------AQDEWKL-------TDKLTLTAGLRYDYYSTFGAsnyTAFSPRLGLRYDL--S 411

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 497 QTSMITAGYNRYY-GGNILDMGLrDIRNSWTESVSGNktltryQNLKTPYNDELAMGLQQKIGKN-VIARANYVYREAHD 574
Cdd:COG4771  412 DNLTLRASYGRGFrAPSLAELYG-SGTGTPGRYVLGN------PDLKPETSDNYELGLEYRLGNGgLSLSLTGFYTDIKD 484

                        570       580       590
                 ....*....|....*....|....*....|....*.
gi 446755183 575 QIskSSRTDSATKTTITEYNNDGKTKTHSFNLSFEL 610
Cdd:COG4771  485 LI--VLVPVGPGPGDVLQYENVGKARTYGLELELKY 518
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 49-790 2.53e-19

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 92.90  E-value: 2.53e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183  49 YTSESIERLPTGNgnISDLLRTNPAVRMDSTQSTslnqgdiRPEKISIHGASPYQNAYLIDGISATNNlnpanesdassa 128
Cdd:cd01347    5 ITAEDIEKQPATS--LADLLRRIPGVSVTRGGGG-------GGSTISIRGFGPDRTLVLVDGLPLASS------------ 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 129 tNISGMSQGYYLDVSLLDNVTLYDSFVPVEFGRFN-GGVIDAKIKR-FNADDSKVKLGYRT-TRSDWLTSHIDENNKSAF 205
Cdd:cd01347   64 -NYGRGVDLNTIPPELIERVEVLKGPSSALYGSGAiGGVVNIITKRpTDEFGGSVTAGYGSdNSGSSGGGGFDVSGALAD 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 206 NQGSSGSTYYSPDFKKNFYTLSFNQELADN--FGVTAGLSRRQSDITRADYvsndgiVAGRAQYKNVIDTALSKFTWFAS 283
Cdd:cd01347  143 DGAFGARLYGAYRDGDGTIDGDGQADDSDEerYNVAGKLDWRPDDDTRLTL------DAGYQDQDADGPGGTLPANGTGS 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 284 DRFTHDLTLKYTGSSRDYNTSTFpqsdremgnKSYGLAWDMDTQLAWAKLRTTVGWdhisDYTRHDHDIWYTELSCTYGD 363
Cdd:cd01347  217 SLGGGPSSNTNGDRDWDYRDRYR---------KRASLGLEHDLNDTGWTLRANLSY----SYTDNDGDPLILNGGNNAAG 283

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 364 itGRCTRGGLGHISQaVDNYTFKTRLDwQKFAVGNVSHQPYFGAEYIYSdawterhnqsesyvinaagkktnhtiyhkgk 443
Cdd:cd01347  284 --GDLGRSGYSSERD-TTQLGFDAGLN-APFGTGPVAHTLTLGVEYRRE------------------------------- 328

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 444 gSLGIDNYTLYMADHISWR-NVSLMPGVRYDY-------------DNYLSNHNISPRFMTEWDIfaDQTSMITAGYNRYY 509
Cdd:cd01347  329 -ELDEKQTALYAQDTIELTdDLTLTLGLRYDHydqdskdtiaggtTAKKSYSHWSPSLGLVYKL--TDGLSLYASYSQGF 405

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 510 GGNILDMGLRDIRNSWTESVSGnktltryQNLKtPY-NDELAMGLQQKIGKNVIARANYVYREAHDQISKSSRTDsaTKT 588
Cdd:cd01347  406 RAPSLGELYGGGSHGGTAAVGN-------PNLK-PEkSKQYELGLKYDPGDGLTLSAALFRIDIKNEIVSTPTNT--GLG 475

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 589 TITEYNNDGKTKTHSFNLSFelaeplhisQVDINPQIVFSyikskGNLSLNNGYEESNTGDNQVVYNGNLvsydsvpvad 668
Cdd:cd01347  476 LVTVYVNGGKARIRGVELEA---------SYDLTDGLGLT-----GSYTYTDTEVKRTDGATTGNRLPGI---------- 531

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 669 fnNPLKISLNMDFTHQPSGLvwanTLAWqearkariilgktNAQYISEYS--DYKQYVDEKLDSSLTWDTRLSWTPqflk 746
Cdd:cd01347  532 --PKHTANLGLDYELPDEGL----TAGG-------------GVRYRGKQYadTANGNNTVKVPGYTLVDLSASYQF---- 588

                        730       740       750       760
                 ....*....|....*....|....*....|....*....|....*..
gi 446755183 747 QQNLTISADILNVLDSK--TAVDTTNTGVATY-ASGRTFWLDVSMKF 790
Cdd:cd01347  589 TKNLTLRLGVNNLFDKDyyTSLSVRGSGLYGYyGPGRTYYLSVSYKF 635
Plug pfam07715
TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently ...
 39-166 7.73e-07

TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.


Pssm-ID: 462243 [Multi-domain]  Cd Length: 107  Bit Score: 48.03  E-value: 7.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183   39 VPVPVngnTHYTSESIERlpTGNGNISDLLRTNPAVRMDSTQSTSLNQgdirpekISIHGASPYQNAYLIDGISATNNLN 118
Cdd:pfam07715   5 TPGSV---SVVTAEDIED--QGATNLADALRGVPGVSVSSGGGGGGSS-------ISIRGFGSNRVLVLVDGVPLNSGGG 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 446755183  119 panesdassatnisGMSQGYYLDVSLLDNVTLYDSFVPVEFGRFN-GGV 166
Cdd:pfam07715  73 --------------GSVDLNSIDPEDIERVEVLKGPASALYGSGAiGGV 107
 
Name Accession Description Interval E-value
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 31-610 3.58e-26

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 114.18  E-value: 3.58e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183  31 EEMTVYAP--------VPVPVngnTHYTSESIERLPTGNgnISDLLRTNPAVRMDSTQSTSLNQGdirpekISIHGASPY 102
Cdd:COG4771   28 EEVVVTATrteqslsdAPASV---SVITAEEIEKLGATD--LADALRLLPGVSVTRSGGRGGSSG------ISIRGLGGD 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 103 QNAYLIDGIsatnnlnPANESDASSATNISgmsqgyYLDVSLLDNVTLYDSFVPVEFG-RFNGGVIDAKIKRFNADDskv 181
Cdd:COG4771   97 RVLVLIDGV-------PVNNPALGGGGDLS------YIPPDDIERIEVIRGPASALYGsDAIGGVINIITKKPTDEL--- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 182 klgyrttrsdwltshidennksafnQGSSGSTYYSPDFKKNFYTLSFNQElADNFGVTAGLSRRQSDITRaDYvsNDGIV 261
Cdd:COG4771  161 -------------------------EGSVSLGYGSNGNGTYSGSLSLGGP-GDKLSFLLSGSYRDRDGYL-DY--RNGGF 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 262 AGRAQYKNviDTALSKFTWFASDRFTHDLTLKYTGSSRDYNTSTFPQSDREmGNKSYGLAWDMDTQLAWAKLRTTVGWDH 341
Cdd:COG4771  212 VGNSGYER--YNLNAKLGYRLSDNHRLSLSGGYSRQDRDGGPPTLGDTEIS-SDNAGDRDTTTDRGNYSLRYNGDLGDNL 288

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 342 ISD--YTRHDHDIWYTELSCTYGDITgrctrgglghiSQAVDNYTFKTRLDWQkfavGNVSHQPYFGAEYIYSDawterh 419
Cdd:COG4771  289 DLSlyYSRTDRDSTNGSLGGSTGSFS-----------DSDDTTYGLELDLTYP----LGGNHTLTLGAEYRYDD------ 347

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 420 NQSESYVINAAGKKTNHTIYhkgkgslGIDNYTLymadhisWRNVSLMPGVRYDYDNYLSN---HNISPRFMTEWDIfaD 496
Cdd:COG4771  348 LDSSSFLGGADASRDTYGLF-------AQDEWKL-------TDKLTLTAGLRYDYYSTFGAsnyTAFSPRLGLRYDL--S 411

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 497 QTSMITAGYNRYY-GGNILDMGLrDIRNSWTESVSGNktltryQNLKTPYNDELAMGLQQKIGKN-VIARANYVYREAHD 574
Cdd:COG4771  412 DNLTLRASYGRGFrAPSLAELYG-SGTGTPGRYVLGN------PDLKPETSDNYELGLEYRLGNGgLSLSLTGFYTDIKD 484

                        570       580       590
                 ....*....|....*....|....*....|....*.
gi 446755183 575 QIskSSRTDSATKTTITEYNNDGKTKTHSFNLSFEL 610
Cdd:COG4771  485 LI--VLVPVGPGPGDVLQYENVGKARTYGLELELKY 518
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 49-790 2.53e-19

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 92.90  E-value: 2.53e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183  49 YTSESIERLPTGNgnISDLLRTNPAVRMDSTQSTslnqgdiRPEKISIHGASPYQNAYLIDGISATNNlnpanesdassa 128
Cdd:cd01347    5 ITAEDIEKQPATS--LADLLRRIPGVSVTRGGGG-------GGSTISIRGFGPDRTLVLVDGLPLASS------------ 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 129 tNISGMSQGYYLDVSLLDNVTLYDSFVPVEFGRFN-GGVIDAKIKR-FNADDSKVKLGYRT-TRSDWLTSHIDENNKSAF 205
Cdd:cd01347   64 -NYGRGVDLNTIPPELIERVEVLKGPSSALYGSGAiGGVVNIITKRpTDEFGGSVTAGYGSdNSGSSGGGGFDVSGALAD 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 206 NQGSSGSTYYSPDFKKNFYTLSFNQELADN--FGVTAGLSRRQSDITRADYvsndgiVAGRAQYKNVIDTALSKFTWFAS 283
Cdd:cd01347  143 DGAFGARLYGAYRDGDGTIDGDGQADDSDEerYNVAGKLDWRPDDDTRLTL------DAGYQDQDADGPGGTLPANGTGS 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 284 DRFTHDLTLKYTGSSRDYNTSTFpqsdremgnKSYGLAWDMDTQLAWAKLRTTVGWdhisDYTRHDHDIWYTELSCTYGD 363
Cdd:cd01347  217 SLGGGPSSNTNGDRDWDYRDRYR---------KRASLGLEHDLNDTGWTLRANLSY----SYTDNDGDPLILNGGNNAAG 283

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 364 itGRCTRGGLGHISQaVDNYTFKTRLDwQKFAVGNVSHQPYFGAEYIYSdawterhnqsesyvinaagkktnhtiyhkgk 443
Cdd:cd01347  284 --GDLGRSGYSSERD-TTQLGFDAGLN-APFGTGPVAHTLTLGVEYRRE------------------------------- 328

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 444 gSLGIDNYTLYMADHISWR-NVSLMPGVRYDY-------------DNYLSNHNISPRFMTEWDIfaDQTSMITAGYNRYY 509
Cdd:cd01347  329 -ELDEKQTALYAQDTIELTdDLTLTLGLRYDHydqdskdtiaggtTAKKSYSHWSPSLGLVYKL--TDGLSLYASYSQGF 405

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 510 GGNILDMGLRDIRNSWTESVSGnktltryQNLKtPY-NDELAMGLQQKIGKNVIARANYVYREAHDQISKSSRTDsaTKT 588
Cdd:cd01347  406 RAPSLGELYGGGSHGGTAAVGN-------PNLK-PEkSKQYELGLKYDPGDGLTLSAALFRIDIKNEIVSTPTNT--GLG 475

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 589 TITEYNNDGKTKTHSFNLSFelaeplhisQVDINPQIVFSyikskGNLSLNNGYEESNTGDNQVVYNGNLvsydsvpvad 668
Cdd:cd01347  476 LVTVYVNGGKARIRGVELEA---------SYDLTDGLGLT-----GSYTYTDTEVKRTDGATTGNRLPGI---------- 531

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 669 fnNPLKISLNMDFTHQPSGLvwanTLAWqearkariilgktNAQYISEYS--DYKQYVDEKLDSSLTWDTRLSWTPqflk 746
Cdd:cd01347  532 --PKHTANLGLDYELPDEGL----TAGG-------------GVRYRGKQYadTANGNNTVKVPGYTLVDLSASYQF---- 588

                        730       740       750       760
                 ....*....|....*....|....*....|....*....|....*..
gi 446755183 747 QQNLTISADILNVLDSK--TAVDTTNTGVATY-ASGRTFWLDVSMKF 790
Cdd:cd01347  589 TKNLTLRLGVNNLFDKDyyTSLSVRGSGLYGYyGPGRTYYLSVSYKF 635
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
31-777 2.28e-14

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 76.79  E-value: 2.28e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183  31 EEMTVYAP--------VPVPVngnTHYTSESIERLPTGNgnISDLLRTNPAVRMDSTQSTSLNqgdirpekISIHGASPY 102
Cdd:COG1629    2 EEVVVTATrtdeslqdVPGSV---SVISREQLEDQPATD--LGDLLRRVPGVSVTSAGGGAGQ--------ISIRGFGGG 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 103 QN--AYLIDGISATNNLNpanesdassatnisGMSQGYYLDVSLLDNVTLYDSFVPVEFGRFN-GGVIDAKIKRFNADDS 179
Cdd:COG1629   69 GNrvLVLVDGVPLNDPSG--------------GDGGLSYIDPEDIERVEVLRGPSSALYGSGAlGGVINIVTKKPKDGKG 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 180 kvklgyrttrsdwltshidennksafnqGSSGSTYYSPDFKKNFYTLSFNQelaDNFGVTAGLSRRQSDitraDYVSNDG 259
Cdd:COG1629  135 ----------------------------GEVSASYGSYGTYRASLSLSGGN---GKLAYRLSASYRDSD----GYRDNSD 179

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 260 IVAgraqyknviDTALSKFTWFASDRFTHDLTLKYTGSSRDYNTSTFPQSDREMGNKSYGLAWDMDTQLAWAKLRTTVG- 338
Cdd:COG1629  180 SDR---------YNLRAKLGYQLGDDTRLTLSASYSDSDQDSPGYLTLAALRPRGAMDDGTNPYSNDTDDNTRDRYSLSl 250

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 339 -WDHISDYTRHDHDIWYTELSCTYG--DITGRCTRGGLGHISQAVDNYTFKTRLDWQKFAVGNVSHQpyFGAEYIYSDaw 415
Cdd:COG1629  251 eYEHLGDGLKLSASAYYRYDDTDLDsdFTPTPADGGTLEQTDFDNRTYGLELRLTYDLGFGGKHTLL--VGLDYQRQD-- 326

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 416 terHNQSESYVINAAGKKTNHTIYHKGKGSlgIDNYTLYMADHISW-RNVSLMPGVRYDYDNY---------------LS 479
Cdd:COG1629  327 ---LDGSGYPLDLGSGSLPTLTSGADDDGT--TTSLALYAQDTYKLtDKLTLTAGLRYDYVSYdvddtvtgtdsasgsRS 401

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 480 NHNISPRFMTEWDIfaDQTSMITAGYNRYYggNILDMGLRDIRNSWTESVSGNktltryqNLKTPYNDELAMGLQQK-IG 558
Cdd:COG1629  402 YSAFSPSLGLTYQL--SPNLSLYASYSRGF--RAPTFGELYANGTDPYSVGNP-------DLKPETSTNYELGLRYRlLD 470

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 559 KNVIARANYVYREAHDQIskSSRTDSATKTTITEYNNDGKTKTHSFNLSFELAeplHISQVDINpqivfsyikskGNLSL 638
Cdd:COG1629  471 GRLSLSLALFYSDVDNEI--LSVPLPNDSGFSTYYTNAGKARSYGVELELSYQ---LTPGLSLN-----------ASYSY 534

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 639 NNGYEESNTgDNQVVYNGNLVSYdsVPvadfnnPLKISLNMDFTHQPSglvWANTLAWqearkariilgktnaQYISEYS 718
Cdd:COG1629  535 TDAKFDDDT-DGSADLDGNRLPG--VP------PLTANLGLTYEFPGG---WSLGLGV---------------RYVGDRY 587

                        730       740       750       760       770       780
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446755183 719 DYKQYVDEKLDSSLTWDTRLSWTPqflkQQNLTISADILNVLDSK--TAVDTTNTGVATYA 777
Cdd:COG1629  588 LDDANTQGAPGGYTLVDLGAGYRF----GDNLTLSLGVDNLFDKKyaTSLSVRASNVRGFL 644
Fiu COG4774
Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];
225-487 3.37e-08

Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];


Pssm-ID: 443806 [Multi-domain]  Cd Length: 639  Bit Score: 57.20  E-value: 3.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 225 TLSFNQELADNFGVTAGLSRRQSDITRaDYVSNDGIVAgraqyknvidtALSkFTWFASDRFTHDLTLKYTGSSR--DYN 302
Cdd:COG4774  132 TLDVNGPLGDDLAYRLNGMYRDSDSYR-DGVDNDRWGI-----------APS-LTWRLGDRTRLTLDYEYQDDDRtpDYG 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 303 TSTFPQSDREMGNKS--YGLAWDMDTQLAWaklRTTVGWDH-ISD---------YTRHDHDIWYTELscTYGDITGRCTR 370
Cdd:COG4774  199 VPAVANGRPVDVDRStfYGQPDDYSDSETD---SATLRLEHdFNDnwtlrnalrYSDYDRDYRNTYP--TGGNATGTVTR 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 371 GGLgHISQAVDNYTFKTRLDWqKFAVGNVSHQPYFGAEYIYSDAWTERHNQSESY---------VINAAGKKTNHTIYHK 441
Cdd:COG4774  274 SAY-RRDQDNDTLSNQTDLTG-KFDTGGVKHTLLAGVEYSREDSDNARYSGGGTAptvnlynpvYGAPVTGPTLGGADND 351

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 442 GKgslgIDNYTLYMADHISW-RNVSLMPGVRYD-----YDNYLSN--------HNISPRF 487
Cdd:COG4774  352 SR----TDTTGLYLQDTISLtDRWSLLAGLRYDrfdtdYTDRTTGattssyddSAFSPRA 407
Plug pfam07715
TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently ...
 39-166 7.73e-07

TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.


Pssm-ID: 462243 [Multi-domain]  Cd Length: 107  Bit Score: 48.03  E-value: 7.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183   39 VPVPVngnTHYTSESIERlpTGNGNISDLLRTNPAVRMDSTQSTSLNQgdirpekISIHGASPYQNAYLIDGISATNNLN 118
Cdd:pfam07715   5 TPGSV---SVVTAEDIED--QGATNLADALRGVPGVSVSSGGGGGGSS-------ISIRGFGSNRVLVLVDGVPLNSGGG 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 446755183  119 panesdassatnisGMSQGYYLDVSLLDNVTLYDSFVPVEFGRFN-GGV 166
Cdd:pfam07715  73 --------------GSVDLNSIDPEDIERVEVLKGPASALYGSGAiGGV 107
FecA COG4772
Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];
233-790 4.01e-06

Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];


Pssm-ID: 443804 [Multi-domain]  Cd Length: 681  Bit Score: 50.31  E-value: 4.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 233 ADNFGVTAGLSRRQSDitraDYvsndgivagRAQYKNVIDTALSKFTWFASDRftHDLTLKYTGSSRDYNT--------- 303
Cdd:COG4772  184 VGNFGYLVEYSRKRGD----GF---------RDNSGFDINDFNAKLGYRLSDR--QELTLKFQYYDEDANTpggltdaqf 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 304 ------STFPQSDREMGNKSYGL--AWDMDTQLawaKLRTTVGWdhiSDYTRHdhdiWYTELSCTYGDITGRCTRGGLGH 375
Cdd:COG4772  249 dadprqSYRPADQFDTRRTQLSLryEHQLSDNT---TLTTTAYY---NDFSRN----WYIRQNTADPNTPGLGLRGNPRG 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 376 isqaVDNYTFKTRLDWQkFAVGNVSHQPYFGAEYIYSDAwTERHNQSESYVINAAGKKTNHTIYhkgkgslGIDNYTLYM 455
Cdd:COG4772  319 ----YRSYGIEPRLTHR-FELGGVPHTLEVGLRYHREEE-DRKQYVNTYGQGRSGAGLRRDRRF-------SADALAAYA 385

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 456 ADHISWR-NVSLMPGVRY-----DYDNYL------------SNHNISP------RFMTEWDIFAD-QTSMITAGYNRYYG 510
Cdd:COG4772  386 QNRFELTgRLTLTPGLRYehirrDRTDRYstrtggddsgsnSYSEFLPglgllyQLTDNLQLYANvSRGFEPPTFGDLAY 465

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 511 GNILDMGLRDIRnSWTESVsGnktlTRYQnlktpyndelamglqqkIGKNVIARANYVYREAHDQISKSSRTDSATKTTI 590
Cdd:COG4772  466 GNGGNPDLKPEK-SWNYEL-G----TRGR-----------------IGNGLSAEVALFYIDYDNELGSCSAAGGDRSTFT 522

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 591 teynNDGKTKTHSFNLSFElAEPLHISQVDINPQIVFSYIKSKgnlslnngYEESNTGdnqvVYNGNLVSYdsVPvadfn 670
Cdd:COG4772  523 ----NAGETRHQGLELALD-YDLLKGGGLGLPLFAAYTYTDAE--------FTSDFGP----VFAGNRLPY--VP----- 578

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 671 nPLKISLNMDFTHQPsglvWANTLawqearkariilgktNAQYISE-YSDY----KQYVDEKLDSSLTWDTRLSWTPqfl 745
Cdd:COG4772  579 -RHQLTAGLGYEHGG----WTANL---------------NGRYVSEqFTDAantvADGSFGKIPSYTVLDLSASYDF--- 635

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*..
gi 446755183 746 kQQNLTISADILNVLDSKTAVDTTNTGVATY--ASGRTFWLDVSMKF 790
Cdd:COG4772  636 -GKNLSLFAGVNNLFDKRYIASRAPNYAAGIrpGPPRTVYAGLRLKF 681
BtuB COG4206
Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];
50-305 4.04e-05

Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];


Pssm-ID: 443355 [Multi-domain]  Cd Length: 276  Bit Score: 46.02  E-value: 4.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183  50 TSESIERLPTGNgnISDLLRTNPAVRMDSTQSTSLNQGdirpekISIHGASPYQNAYLIDGIsatnnlnPANeSDASSAT 129
Cdd:COG4206   23 DAEELERSGATS--LADALRRVPGVQVSSSGGPGSAAS------ISIRGLGSNQTLVLIDGV-------PLN-DPSLGGV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 130 NISgmsqgyYLDVSLLDNVTLYDSFVPVEFG-RFNGGVI---------------DAKIKRFNADDSKVKLGYRTTRSDWL 193
Cdd:COG4206   87 DLS------LIPPDDIERIEVLKGAASALYGsDAIGGVInittkkgkkgfkgsvSASYGSFGTRRLSASLSGGAGKFSYS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 194 TS--HIDENNKSAFNQGSSGSTyyspDFKKNFYTLSFNQELADN--FGVTAGLSRRQSDITRADYVSNDGIVAGRAQYKN 269
Cdd:COG4206  161 LSasYRRSDGYRYNDPDLRNND----GYENTSLNARLGYKLGDNgsLSLSGGYSDSERGYPGAVGSDRNLRLSLSLEYKL 236

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 446755183 270 VIDTALSKFTWFASDRFTHDLTLKYTGSSRDYNTST 305
Cdd:COG4206  237 SDGWSLLLLAYYYYDRDYEDGGGDSAGTSNTDGARA 272
TonB_dep_Rec pfam00593
TonB dependent receptor; This model now only covers the conserved part of the barrel structure.
 281-789 1.46e-04

TonB dependent receptor; This model now only covers the conserved part of the barrel structure.


Pssm-ID: 395474 [Multi-domain]  Cd Length: 475  Bit Score: 45.15  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183  281 FASDRFTHDLTLKYTGSSRDYNTSTFPQSDREMGNKSYGLAWDMDTQLA-WAKLRTTVGWDhisdYTRHDHDIWYTEL-- 357
Cdd:pfam00593   8 LLGDDTLLTLGYDYSRYTDGLDLGLTLDGYGNDGGYLGDRPLYYGRDYSdTDRKRLSLGYD----YDLGDGLSWLSTLrl 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183  358 ----SCTYGDITGRCTRGGLGHISQAVDNYTFKTRLDWQKFAVGNVSHQPYFGAEYIYSDA-WTERHNQSESYVINAAGK 432
Cdd:pfam00593  84 glrySSLDGDYTSNSSGLSGAGDYLSDDRLYGLYGLDGDLELSLDLSHDLLLGVELRTAGLdYRRLDDDAYDPYDPANPS 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183  433 KTNHTIYHKgkgslgiDNYTLYMADHISWR-NVSLMPGVRYDYDNY-------------LSNHNISPRFMTEWDIFADQT 498
Cdd:pfam00593 164 SSSYSDTTT-------DSYGLYLQDNIKLTdRLTLTLGLRYDHYSTdgddgngggdnfsRSYSAFSPRLGLVYKPTDNLS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183  499 smITAGYNRYY-GGNILDMGLRDIRNSWTESVSGNKtltryqNLKTPYNDELAMGLQQKiGKNVIARANYVYREAHDQIS 577
Cdd:pfam00593 237 --LYASYSRGFrAPSLGELYGSGSGGGGGAVAGGNP------DLKPETSDNYELGLKYD-DGRLSLSLALFYIDIKNLIT 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183  578 kSSRTDSATKTTITEYNNDGKTKTHSFNLSFELAeplhisqvdinpqiVFSYIKSKGNLSLNNgyeesNTGDNQVVYNGN 657
Cdd:pfam00593 308 -SDPDGPGLGGTVYTYTNVGKARIRGVELELSGR--------------LWGLGLSGGGYTYTD-----ADDDADADDTGN 367

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183  658 LVSYDSvpvadfnnPLKISLNMDFTHQPSGlvWANTLAWQEARKARIILGKTNAQYiseysdykqyvdeKLDSSLTWDTR 737
Cdd:pfam00593 368 PLPNVP--------RHTANLGLTYDFPLGG--WGARLGARYVGSGERRYGDAANTF-------------KTPGYTLVDLS 424

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 446755183  738 LSWTPQflkqQNLTISADILNVLD---SKTAVDTTNTGVATYASGRTFWLDVSMK 789
Cdd:pfam00593 425 AGYRLN----KNLTLRLGVNNLFDkyyKRYYSSGGGNLGGYPGPGRTFYLGLSYK 475
FhuE COG4773
Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion ...
 278-487 2.35e-03

Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism];


Pssm-ID: 443805 [Multi-domain]  Cd Length: 692  Bit Score: 41.42  E-value: 2.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 278 FTWFASDRFTHDLTLKYTGSSRDYNTSTFPQSDREMG---NKSYGLAWD-MDTQlawaKLRTTVGWDH-ISD-------- 344
Cdd:COG4773  231 LDWDLTDDTTLTLGAEYQDDDSTGDRGFLPLDGTLLDlprSTNLGEPWDyYDTE----TTTLFAELEHrFNDdwslrana 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446755183 345 -YTRHDHDIWYTELSCTYGDITGRCTRGGlGHISQAVDNYTFKTRLDWqKFAVGNVSHQPYFGAEYIYSDAWTERHNQSE 423
Cdd:COG4773  307 rYSDSDRDGRSAYAYGAPDAATGTLTRYA-SARDGDSRSDSLDANLNG-KFETGGLEHTLLVGADYSRYDSDSDSATAGT 384

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446755183 424 SYVINAAGKKTNHTIYHKGKGSLGIDNYTLYMADHISW-RNVSLMPGVRYDY------------DNYLSNHNISPRF 487
Cdd:COG4773  385 INIYNPVYGNLPEPDFDASDTDTTTRQTGLYAQDQISLtDRLSLLLGGRYDWyetdstnrlggsTTSYDDSAFTPRA 461
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH