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Conserved domains on  [gi|446751936|ref|WP_000829192|]
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MULTISPECIES: HNH endonuclease [Escherichia]

Protein Classification

HNH endonuclease( domain architecture ID 10003646)

HNH endonuclease contains an HNH endonuclease signature motif and may catalyze the hydrolysis of DNA

Gene Ontology:  GO:0004519|GO:0003676|GO:0008270
PubMed:  28211904

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
28-91 1.18e-14

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


:

Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 63.46  E-value: 1.18e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446751936  28 RVSGSARVSLKRHIWLRDAGQCCLCGRVVDLCDSELDHRIALQFGGGNEETNLWTLCTECHRQK 91
Cdd:COG1403    1 RRPGREWPALRRAVLKRDNGRCQYCGRPFSGDALEVDHIIPRSRGGTDTWENLVLLCRRCNRRK 64
 
Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
28-91 1.18e-14

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 63.46  E-value: 1.18e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446751936  28 RVSGSARVSLKRHIWLRDAGQCCLCGRVVDLCDSELDHRIALQFGGGNEETNLWTLCTECHRQK 91
Cdd:COG1403    1 RRPGREWPALRRAVLKRDNGRCQYCGRPFSGDALEVDHIIPRSRGGTDTWENLVLLCRRCNRRK 64
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
38-92 9.17e-09

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 48.24  E-value: 9.17e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446751936  38 KRHIWLRDAGQCCLCGRVVDLCDSELDHRIALQFGGGNEETNLWTLCTECHRQKS 92
Cdd:cd00085    3 HRLVLLARDGLCPYCGKPGGTEGLEVDHIIPLSDGGNNDLDNLVLLCRKCHRKKH 57
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
49-94 7.55e-05

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 37.72  E-value: 7.55e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 446751936   49 CCLCGRVVDLCDS-ELDHRIALQFGGGNEETNLWTLCTECHRQKSAR 94
Cdd:pfam01844   1 CQYCGRPFHISDAlTVDHIIPLSDGGADDIENLILLCPSCHNKKHNR 47
guided_IscB NF040563
RNA-guided endonuclease IscB;
44-96 5.19e-04

RNA-guided endonuclease IscB;


Pssm-ID: 468538 [Multi-domain]  Cd Length: 315  Bit Score: 37.92  E-value: 5.19e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446751936  44 RDAGQCCLCG-RVVDLcdsELDHRIALQFGGGNEETNLWTLCTECHRQKSAREA 96
Cdd:NF040563 191 RDGRTCQYCGaKDVPL---EVHHIVPRSKGGSDRVSNLILACEPCNQKKGNQPV 241
 
Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
28-91 1.18e-14

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 63.46  E-value: 1.18e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446751936  28 RVSGSARVSLKRHIWLRDAGQCCLCGRVVDLCDSELDHRIALQFGGGNEETNLWTLCTECHRQK 91
Cdd:COG1403    1 RRPGREWPALRRAVLKRDNGRCQYCGRPFSGDALEVDHIIPRSRGGTDTWENLVLLCRRCNRRK 64
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
38-92 9.17e-09

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 48.24  E-value: 9.17e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446751936  38 KRHIWLRDAGQCCLCGRVVDLCDSELDHRIALQFGGGNEETNLWTLCTECHRQKS 92
Cdd:cd00085    3 HRLVLLARDGLCPYCGKPGGTEGLEVDHIIPLSDGGNNDLDNLVLLCRKCHRKKH 57
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
49-94 7.55e-05

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 37.72  E-value: 7.55e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 446751936   49 CCLCGRVVDLCDS-ELDHRIALQFGGGNEETNLWTLCTECHRQKSAR 94
Cdd:pfam01844   1 CQYCGRPFHISDAlTVDHIIPLSDGGADDIENLILLCPSCHNKKHNR 47
HNH_5 pfam14279
HNH endonuclease; This domain is related to other HNH domain families such as pfam01844. ...
49-94 9.61e-05

HNH endonuclease; This domain is related to other HNH domain families such as pfam01844. Suggesting that these proteins have a nucleic acid cleaving function.


Pssm-ID: 464124 [Multi-domain]  Cd Length: 56  Bit Score: 37.70  E-value: 9.61e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 446751936   49 CCLCGRVVDLCDSELDHRIALQFGGGNEETNLWTLCTECHRQKSAR 94
Cdd:pfam14279   1 CIYCGKEFPEKNLTIEHIIPESLGGKNKISNLQTLCKKCNSKKGHD 46
guided_IscB NF040563
RNA-guided endonuclease IscB;
44-96 5.19e-04

RNA-guided endonuclease IscB;


Pssm-ID: 468538 [Multi-domain]  Cd Length: 315  Bit Score: 37.92  E-value: 5.19e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446751936  44 RDAGQCCLCG-RVVDLcdsELDHRIALQFGGGNEETNLWTLCTECHRQKSAREA 96
Cdd:NF040563 191 RDGRTCQYCGaKDVPL---EVHHIVPRSKGGSDRVSNLILACEPCNQKKGNQPV 241
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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