|
Name |
Accession |
Description |
Interval |
E-value |
| emrD |
PRK11652 |
multidrug transporter EmrD; |
1-394 |
0e+00 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 610.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 1 MKRQRNVNLLLMLVLLVAVGQMAQTIYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGM 80
Cdd:PRK11652 1 MKRQRNVNLLFMLVLLVAVGQMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 81 SIFMVATLIAMTTHSLTVLIAASAMQGMGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWN 160
Cdd:PRK11652 81 SIFILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 161 WRACYAFLLVLCAGVTFSMARWMPETRPAGAPRTRLIASYKTLFGNGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGL 240
Cdd:PRK11652 161 WRACYLFLLLLGAGVTFSMARWMPETRPADARRTRVLASYRTLLSNRRFNCYLLMLIGTLAGIAVFEACSGVLMGAVLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 241 SSMVVSILFILPIPAAFFGAWFAGRPNKRFSTLMWQSVICCLLAGLMMWIPGWFGVMNVWTLLIPAALFFFGAGMLFPLA 320
Cdd:PRK11652 241 SSMTVSILFILPIPAAFFGAWFAGRPNKRFSTLMWQSVICCLLAGLLMWIPGWFGVMNVWTLLVPAALFFFGAGMLFPLA 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446751488 321 TSGAMEPFPFLAGTAGALVGGLQNIGSGVLAWLSAMLPQTGQGSLGLLMTLMGLLILACWLPLASRISHQGQTV 394
Cdd:PRK11652 321 TSGAMEPFPYLAGTAGALLGGLQNIGSGLAALLSAMLPQTGQFSLGLLMTLMGLLILLCWLPLATRMSHQGQPV 394
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
20-383 |
7.58e-86 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 265.59 E-value: 7.58e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 20 GQMAQTIYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVL 99
Cdd:cd17320 11 GPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 100 IAASAMQGMGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLCAGVTFSM 179
Cdd:cd17320 91 LIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 180 ARWMPETRPAGAPRT---RLIASYKTLFGNGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMVVSILFILPIPAA 256
Cdd:cd17320 171 LLFLPETLPEEKRKPllsSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 257 FFGAWFAGRPNKRFS--TLMWQSVICCLLAGLMMWIPGWFGVMNVWTLLIPAALFFFGAGMLFPLATSGAMEPFPFLAGT 334
Cdd:cd17320 251 ILGSLLNGRLVRRFGprRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGT 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 446751488 335 AGALVGGLQNIGSGVLAWLSAMLPQTGQGSLGLLMTLMGLLILACWLPL 383
Cdd:cd17320 331 ASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
22-349 |
5.43e-37 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 137.41 E-value: 5.43e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 22 MAQTIYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIA 101
Cdd:COG2814 24 LGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 102 ASAMQGMGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLCAGVTFSMAR 181
Cdd:COG2814 104 ARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLR 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 182 WMPETRPagAPRTRLIASYKTLFGNGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMVVSILFILPIPAAFFGAW 261
Cdd:COG2814 184 LLPESRP--AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGAL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 262 FAGRPNKRFStLMWQSVICCLLAGLMMWIPGWFGvmNVWTLLIPAALFFFGAGMLFPLATSGAMEPFP-FLAGTAGALVG 340
Cdd:COG2814 262 LAGRLADRFG-RRRLLLIGLLLLALGLLLLALAG--SLWLLLLALFLLGFGFGLLFPLLQALVAELAPpEARGRASGLYN 338
|
....*....
gi 446751488 341 GLQNIGSGV 349
Cdd:COG2814 339 SAFFLGGPL 347
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
20-343 |
3.86e-35 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 133.28 E-value: 3.86e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 20 GQMAQTIYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVL 99
Cdd:TIGR00710 17 GPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 100 IAASAMQGMGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLCAGVTFSM 179
Cdd:TIGR00710 97 LVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALI 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 180 ARWMPETRPAGApRTRLIASYKT---LFGNGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMVVSILFILPIPAA 256
Cdd:TIGR00710 177 FFILPETLPYEA-RIQISTYFETfllLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAM 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 257 FFGAWFAGRPNKRFS--TLMWQSVICCLLAGLMMWIPGWFGVMNVWTLLIPAALFFFGAGMLFPLATSGAMEPFPFLAGT 334
Cdd:TIGR00710 256 IFGGFLNGRFIKKWGakSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGIGNSMISSIAMAYALEDFPHVAGT 335
|
....*....
gi 446751488 335 AGALVGGLQ 343
Cdd:TIGR00710 336 ASALFGTLR 344
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
28-357 |
7.04e-28 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 112.64 E-value: 7.04e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 28 IPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIAASAMQG 107
Cdd:cd17324 19 QGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 108 MGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLCAGVTFSMARWMPETR 187
Cdd:cd17324 99 LAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 188 PAGAPRTRLIASYKTLFGNGAFncYLLMLIGGLAGIAVFEACS--GVLMGAVLGLSSMVVSILFILPIPAAFFGAWFAGR 265
Cdd:cd17324 179 PKKPGSLGLLSSLLLLLRNPRL--RLAYLITFLLFGGFFALYTylAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 266 PNKRFSTLMWqSVICCLLAGLMMWIPGWFGvmNVWTLLIPAALFFFGAGMLFPLATSGAMEPFPFLAGTAGALVGGLQNI 345
Cdd:cd17324 257 LADRGGRRAL-LIALLLLAAALLLLTLLGP--SPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNL 333
|
330
....*....|..
gi 446751488 346 GSGVLAWLSAML 357
Cdd:cd17324 334 GGALGAALGGLV 345
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
52-186 |
3.78e-27 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 105.04 E-value: 3.78e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 52 YLLTYGVSQLFYGPLS----DRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIAASAMQGMGTGVGGVMARTLPRDLYEG 127
Cdd:TIGR00880 3 LLAGYALGQLIYSPLSglltDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPP 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 446751488 128 TQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLCAGVTFSMARWMPET 186
Cdd:TIGR00880 83 EERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
27-356 |
9.40e-27 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 109.62 E-value: 9.40e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 27 YIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIAASAMQ 106
Cdd:PRK11102 10 YLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLH 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 107 GMGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYaFLLVLCAGVTFSMARWM-PE 185
Cdd:PRK11102 90 GLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIF-WVLALAAILAAALVFFFiPE 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 186 TRPAGApRTRL-----IASYKTLFGNGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMVVSILFILPIPAAFFGA 260
Cdd:PRK11102 169 TLPKER-RQPFhlrttIRNFASLFRHKRVLGYMLASGFSFAGMFSFLTAGPFVYIELNGVSPQNFGYYFALNIVFLFVMT 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 261 WFAGRPNKRF--STLMWQSVICCLLAGLMMWIPGWFGVmNVWTLLIPAALFFFGAGMLFPLATSGAMEPFPFLAGTAGAL 338
Cdd:PRK11102 248 IINSRFVRRVgaLNMLRFGLWIQFIMGIWLVVSALLDL-GFWALVVGVAAFVGCVSMISSNAMAVILDEFPHMAGTASSL 326
|
330
....*....|....*....
gi 446751488 339 VGGLQ-NIGSGVLAWLSAM 356
Cdd:PRK11102 327 AGTLRfGIGAIVGALLSLA 345
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
22-357 |
6.47e-22 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 96.10 E-value: 6.47e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 22 MAQTIYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIA 101
Cdd:cd17474 13 LGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 102 ASAMQGMGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLdTLWNWRACYAFLLVLCAGVTFSMAR 181
Cdd:cd17474 93 GRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL-AAISWRYPFFLLAALIPVAFLAILF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 182 WMPET-RPAGAPRTRLIASYKTLFGNGAFncyLLMLIGGLAGIAVFEAC---SGVLMGAVLGLSSMVVSILFILPIPAAF 257
Cdd:cd17474 172 LLPEPkEKAKSSSATKLRDLKKALRGRGL---LTFLVSAFLYFFLYFAFltyLPFLLELLYGISPIIIGLLFAGWSVLLA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 258 FGAWFAGRPNKRF----STLMWQSVICCLLAGLMMWIPgwfgvmNVWTLLIPAALFFFGAGMLFPLATSGAMEPFP-FLA 332
Cdd:cd17474 249 LGSLFVGRLLKKRfgarRILVIGLLLYALSLLLLGFVP------SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPeEER 322
|
330 340
....*....|....*....|....*
gi 446751488 333 GTAGALVGGLQNIGSGVLAWLSAML 357
Cdd:cd17474 323 GTASSLYNFVRFLGQAVGPLLFGLL 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
22-349 |
8.61e-22 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 95.18 E-value: 8.61e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 22 MAQTIYIPAIA-DMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLI 100
Cdd:pfam07690 10 LGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 101 AASAMQGMGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLCAGVTFSMA 180
Cdd:pfam07690 90 VLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 181 RWMPET-----RPAGAPRTRLIASYKTLFGNGAFNCYLLMLIGGLAGIAVFEacSGVLMGAVLGLSSMVVSILFILPIPA 255
Cdd:pfam07690 170 LPRPPPeskrpKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLT--YLPLYQEVLGLSALLAGLLLGLGGLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 256 AFFGAWFAGRPNKRFSTLMWQSVICCLLAGLMMWIPGWFGVMNVWTLLIPAALFFFGAGMLFPLATSGAMEPFPF-LAGT 334
Cdd:pfam07690 248 GAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKeERGT 327
|
330
....*....|....*
gi 446751488 335 AGALVGGLQNIGSGV 349
Cdd:pfam07690 328 ASGLYNTAGSLGGAL 342
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
20-349 |
3.78e-21 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 93.78 E-value: 3.78e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 20 GQMAQTIYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVL 99
Cdd:cd17321 8 AALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 100 IAASAMQGMGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLCAGVTFSM 179
Cdd:cd17321 88 IAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 180 arwmpetrpagapRTRLIASYKTLFGNGAFNCYLLMLIgglagiavfeacsgVLMGAVLGLSSMVVSILFILPIPAAFFG 259
Cdd:cd17321 168 -------------RTFSGAVLAAFLLGAALGGLLFLLP--------------LYLQGVLGYSPLQAGLALLPLALAMLVA 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 260 AWFAGRPNKRFSTLMWQSVICCLLAGLMMWIPGWFGVMNVWTLLIPAALFFFGAGMLFPLATSGAMEPFPF-LAGTAGAL 338
Cdd:cd17321 221 APLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKeKAGAASGI 300
|
330
....*....|.
gi 446751488 339 VGGLQNIGSGV 349
Cdd:cd17321 301 LNTARQLGGAL 311
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
20-343 |
8.05e-21 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 93.03 E-value: 8.05e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 20 GQMAQTIYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVL 99
Cdd:PRK11043 18 GFLATDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 100 IAASAMQGMGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLCAGVTFSM 179
Cdd:PRK11043 98 LVLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIFATLFAITLLLILPT 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 180 ARWMPETRPAGAPRTRLiaSYKTLFGNGAFncyllmliggLAGIAVFEACSG----------VLMGAvLGLSSMVVSILF 249
Cdd:PRK11043 178 LRLKPSKKARKQSQDAL--TFKQLLKSKTY----------LGNVLIFAACSAaffawltgspFILEQ-MGYSPADIGLSY 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 250 IlPIPAAFFGAWFAGRPN-KRFSTlmwQSVICCLLAG-----LMMWIPGWFGVMNVWTLLIPAALFFFGAGMLFPLATSG 323
Cdd:PRK11043 245 V-PQTIAFLVGGYGCRAAlQKWGG---EQLLPWLLVLfavsvIAIWLASLLSHPSLVPLLIPFCVMAAANGAIYPIVVAQ 320
|
330 340
....*....|....*....|
gi 446751488 324 AMEPFPFLAGTAGALVGGLQ 343
Cdd:PRK11043 321 ALRPFPQATGKAAALQNTLQ 340
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
26-357 |
4.38e-20 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 90.85 E-value: 4.38e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 26 IYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIAASAM 105
Cdd:PRK10473 21 MYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 106 QGMGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLCAGVTFSMARWMPE 185
Cdd:PRK10473 101 QGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFILKE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 186 TRPAGAPRTRLIASYKT-LFGNGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLS----SMVVSILFILPIPAAFFGA 260
Cdd:PRK10473 181 TRPARAPAASSKPRENSeSLLNRFFLSRLVITTLSVTVILTFVNTSPVLLMEQMGFSrgeyAIIMALTAGVSMTVSFSTP 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 261 WFAGRPNKRfsTLMWQSVICCLLAGLMMWIpGWFGvmnvWTLLIPAALFFFGAGMLFPLATSGAMEPFPFLAGTAGALVG 340
Cdd:PRK10473 261 FALGIFKPR--TLMLTSQVLFLAAGITLAL-SPSH----AVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLG 333
|
330
....*....|....*..
gi 446751488 341 GLQNIGSGVLAWLSAML 357
Cdd:PRK10473 334 IAQVCGSSLWIWLAAVL 350
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
22-357 |
8.36e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 89.94 E-value: 8.36e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 22 MAQTIYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIA 101
Cdd:cd17325 10 LGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 102 ASAMQGMGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLCAGVTFSMAR 181
Cdd:cd17325 90 ARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 182 WMPETRPAGAPRT----RLIASYKTLFGNGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMVVSILFILPIPAAF 257
Cdd:cd17325 170 LLPEPRPPPNKRAvsaaRLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 258 FGAWFAGRPNKRFSTLMWqSVICCLLAGLMMWIPGWFGvmNVWTLLIPAALFFFGAGMLFPLATSGAMEPFP-FLAGTAG 336
Cdd:cd17325 250 LSQPPAGKLSDRIGRKPL-ILIGLLLSAVALLLLPLAT--SFWLLLLLLALLGLGLGLVFPATLALLADIVPpEGRGTAM 326
|
330 340
....*....|....*....|.
gi 446751488 337 ALVGGLQNIGSGVLAWLSAML 357
Cdd:cd17325 327 GLFNTAFSLGMVLGPLLGGFL 347
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
22-265 |
4.37e-19 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 86.79 E-value: 4.37e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 22 MAQTIYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIA 101
Cdd:COG0477 28 LDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 102 ASAMQGMGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLcAGVTFSMAR 181
Cdd:COG0477 108 ARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPL-GLLALVLRL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 182 WMPETRPAGAPRTRLIASYKTLFGNGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMVVSILFILPIPAAFFGAW 261
Cdd:COG0477 187 RLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLL 266
|
....
gi 446751488 262 FAGR 265
Cdd:COG0477 267 LLLL 270
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
20-349 |
2.41e-18 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 85.70 E-value: 2.41e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 20 GQMAQTIYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVL 99
Cdd:cd17323 11 VTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAML 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 100 IAASAMQGMGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLCAGVTFSM 179
Cdd:cd17323 91 IILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 180 ARWMPETrpagaprtrliasyktlfgngafnCYLLMLIGGLAGI--AVFEACSGVLMGaVLGLSSMVVSILFILPIPAAF 257
Cdd:cd17323 171 FLFLPIV------------------------LLLGLYVGLVYAIlyLFLTAFPYVFGE-VYGFSPGEVGLMYLPIGIGAL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 258 FGAWFAGRPNKRF--------------STLMWQSVICCLLAGLMMWIPGW--FGVMNVWTLLIPAALFFFGAGMLFPLAT 321
Cdd:cd17323 226 IGSIIGGRLSDYYyrrlkkknggkpepEARLPPAFIGAFLFPIGLFIFGWtiYPHIHWIVPIIGSAFFGFGLMLIFQSSL 305
|
330 340
....*....|....*....|....*...
gi 446751488 322 SGAMEPFPFLAGTAGALVGGLQNIGSGV 349
Cdd:cd17323 306 TYLVDSYPKYAASALAANTLVRSIFAAI 333
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
30-357 |
3.18e-17 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 82.23 E-value: 3.18e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 30 AIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIAASAMQGMG 109
Cdd:COG2271 32 AAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 110 TGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLCAGVtfsmarwmpetrpa 189
Cdd:COG2271 112 EAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLL-------------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 190 GAPRTRLIAsyktlFGNGAFNCYLLMLIGGLAGIAVFEacsgvlMGAVLGLSSMVVSILFILPIPAAFFGAWFAGRPNKR 269
Cdd:COG2271 178 ALLRFWLLA-----LAYFLVYFALYGFLTWLPTYLVEV------RGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 270 FSTLMwqsVICCLLAGLMMWIPGWFGvmNVWTLLIPAALFFFGAGMLFPLATSGAMEPFP-FLAGTAGALVGGLQNIGSG 348
Cdd:COG2271 247 RKLVL---AIGLLLAALALLLLALLP--SPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGA 321
|
....*....
gi 446751488 349 VLAWLSAML 357
Cdd:COG2271 322 LGPLLVGYL 330
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
20-357 |
2.28e-15 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 76.85 E-value: 2.28e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 20 GQMAQTIYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVL 99
Cdd:cd17503 8 AILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 100 IAASAMQGMGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLCAGVTfsm 179
Cdd:cd17503 88 IIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILAL--- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 180 arwmpetrpAGAPRTRLiasykTLFGNGAFNcyLLMLIGGLAGIAVFeaCSGVLM----GAVLGLSSMVVSILFILPIPA 255
Cdd:cd17503 165 ---------LLAPLLDL-----RLFKDRNFT--LGLLLSFLLGLGLF--GAMFLLplylQNVLGYSAFESGLVLAPGGLA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 256 AFFGAWFAGRPNKRFSTLMWQSVICCLLAGLMMWIPGWFGVMNVWTLLIPAALFFFGAGMLF-PLATSGAMEPFPFLAGT 334
Cdd:cd17503 227 SAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFmPLNTLALNSLPPEQIGD 306
|
330 340
....*....|....*....|....
gi 446751488 335 AGALVGGLQNIGSGV-LAWLSAML 357
Cdd:cd17503 307 ATALFNTIRQLGGSIgTALLATLL 330
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
22-363 |
7.54e-15 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 75.16 E-value: 7.54e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 22 MAQTIYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIA 101
Cdd:cd06174 10 LARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 102 ASAMQGMGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDT--LWNWRACYAFLLVLCAGVTFSM 179
Cdd:cd06174 90 GRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAALALLAAILL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 180 ARWMPETRPAGAPR------TRLIASYKTLFGNGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMVVSILFILPI 253
Cdd:cd06174 170 LLVVPDPPESARAKneeassKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 254 PAAFFGAWFAGRPNKRFSTLMWQSVICCLLAGLMMWIPGWFGVMNVWTLLipAALFFFGAGMLFPLATSGAMEPFPF-LA 332
Cdd:cd06174 250 LAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLL--LLLLGFGLGGLLPLSFALIAELFPPeIR 327
|
330 340 350
....*....|....*....|....*....|.
gi 446751488 333 GTAGALVGGLQNIGSGVLAWLSAMLPQTGQG 363
Cdd:cd06174 328 GTAFGLLNTFGFLGGAIGPLLAGFLLAATFG 358
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
29-264 |
1.01e-14 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 74.98 E-value: 1.01e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 29 PAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIAASAMQGM 108
Cdd:PRK15402 34 PGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 109 GTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLCAGVTFSMARWMPETrp 188
Cdd:PRK15402 114 GLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWRAMPET-- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 189 AGAPRTR-----LIASYKTLFGNGAFNCYLLMLigGLAGIAVFE--ACSGVLMGAVLGLSSMVVSILFIlPIpaafFGAW 261
Cdd:PRK15402 192 AGRVGEKlslkeLGRDYKLVLKNRRFVAGALAL--GLVSLPLLAwiALSPVILISGEQLSSYEYGLLQV-PV----FGAL 264
|
...
gi 446751488 262 FAG 264
Cdd:PRK15402 265 IAG 267
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
22-357 |
6.16e-14 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 72.61 E-value: 6.16e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 22 MAQTIYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIA 101
Cdd:COG2223 19 GVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 102 ASAMQGMGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLCAGVTFSMAR 181
Cdd:COG2223 99 LGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 182 WMPET-RPAGAPRTRLIASYKTLFGNGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMVV-SILFILPIPAAF-- 257
Cdd:COG2223 179 FLRDPpAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAgLLAALFALLGALgr 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 258 -FGAWFAGRPNKRfSTLMWQSVICCLLAGLMMWIPGwfgvmNVWTLLIPAALFFFGAGMLFPLATSGAMEPFPF-LAGTA 335
Cdd:COG2223 259 pLGGWLSDRIGGR-RVLLIVFALMALGLLLLALALG-----SLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTkNAGAV 332
|
330 340
....*....|....*....|..
gi 446751488 336 GALVGGLQNIGSGVLAWLSAML 357
Cdd:COG2223 333 YGLVGAAGGLGGFLGPLLFGAL 354
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
22-322 |
5.30e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 63.77 E-value: 5.30e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 22 MAQTIYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVG-----RRPVILVGMSIFMVATLIAMTTHSL 96
Cdd:COG2211 25 AFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPDL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 97 T------VLIAASAMQGMGTGVGGVMARTLPRDLYEGTQLR-HANSLLNMGILVSPLLAPLIGGLL------DTLWNWRA 163
Cdd:COG2211 105 SptgkliYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERtRLSSWRFAFAGLGGLLASVLPPPLvaafggDAALGYRL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 164 CYAFLLVLCAGVTFSMARWMPETRPAGAPRTRLIASYKTLFGNGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSM 243
Cdd:COG2211 185 TALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAA 264
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446751488 244 VVSILFILPIPAAFFGAWFAGRPNKRFSTLMWqSVICCLLAGLMMWIPGWFGVMNVWTLLIPAALFFFGAGMLFPLATS 322
Cdd:COG2211 265 LVGLLLALYFLAALLGAPLWPRLAKRFGKKKA-FIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWA 342
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
34-320 |
1.49e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 62.24 E-value: 1.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 34 MAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIAASAMQGMGTGVG 113
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 114 GVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLdTLWNWRACYAFLLVLCAGVTFSMARWMPETRPAGAPR 193
Cdd:cd17329 106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL-LLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 194 --TRLIASYKTLFGNGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMVVSILFILPIPAAFFGAWFAGRPNKRFS 271
Cdd:cd17329 185 ekTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFR 264
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 446751488 272 TLMWQSVICCLLAGLMMWIPgwfGVMNVWTLLIPAALFFFGAGMLFPLA 320
Cdd:cd17329 265 LRKILMIGILLFAIGFAVLA---FANTLAVLILAMIVLTLGEMLVFPAV 310
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
22-330 |
1.69e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 61.82 E-value: 1.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 22 MAQTIYIPAIADMAQA-LNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLI 100
Cdd:cd17473 13 MAGAAIAPALPAIAQHfVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 101 AASAMQGMGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLwNWRacYAFLLVLCAGVTFSMA 180
Cdd:cd17473 93 ASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWR--APFLVYLLALPVLILV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 181 -RWMPETRPAGAPRTRLIASYKTLFGNGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMVVSILFILPIPAAFFG 259
Cdd:cd17473 170 lLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIG 249
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446751488 260 AWFAGRPNKRFSTLMWQSVICCLLAG--LMMWIPGwfgvmNVWTLLIPAALFFFGAGMLFPLATSGAMEPFPF 330
Cdd:cd17473 250 ALLFGRLKRRLGKRRLLAIGFALMALgfLLLALAS-----GLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPP 317
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
50-347 |
4.67e-10 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 60.27 E-value: 4.67e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 50 AAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIAASAMQGMGTGVGGVMARTLPRDLYEGTQ 129
Cdd:cd17502 37 TAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 130 LRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYaFLLVLCAGVTFSMARwmpetrpagaprtrliasyktlfgnGAF 209
Cdd:cd17502 117 RGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCF-YINLPIGGLALALLR-------------------------TIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 210 NCYLLMLIGGLAGIAVFeACSGVLMGAVLGLS---SMVVSILFILPIP-AAFFGAWFAGRpNKRFSTLMWQSVICCLL-A 284
Cdd:cd17502 171 LSSIFGFLFGGALFGLI-YYLPLYFQLVLGDSatkSGVRLLPLIIGLViGSIISGALISK-TGRYKPLIVIGTILMSVgA 248
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446751488 285 GLMMWIPgwfGVMNVWTLLIPAALFFFGAGMLFPLATSGAMEPFP-FLAGTAGALVGGLQNIGS 347
Cdd:cd17502 249 GLLTTLT---LDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPpADVGVATATNTFFRSLGG 309
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
29-318 |
7.58e-10 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 60.23 E-value: 7.58e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 29 PAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIAASAMQGM 108
Cdd:PRK15403 37 PGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 109 GTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLCAGVTFSMARWMPETRP 188
Cdd:PRK15403 117 SICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVK 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 189 AGAPRTRLIA---SYKTLFGNGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSS-----MVVSILFILPIPAAFFGA 260
Cdd:PRK15403 197 RGAVPFSAKSvlrDFRNVFRNRLFLTGAATLSLSYIPMMSWVAVSPVILIDAGGMTTsqfawTQVPVFGAVIVANAIVAR 276
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446751488 261 WFAGRPNKRFstlMWQSV------ICCLLAGLMMWIPGWFgvmnvWTLLiPAALFFFGAGMLFP 318
Cdd:PRK15403 277 FVKDPTEPRF---IWRAVpiqlvgLALLIVGNLLWPHVWL-----WSVL-GTSLYAFGIGLIFP 331
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
49-322 |
2.78e-09 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 58.38 E-value: 2.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 49 MAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIAASAMQGMGTGVGGVMArtLPRDLYEGT 128
Cdd:cd17472 38 LGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAISSVVMA--LLADLTREE 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 129 QLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLCAGVTFSMARWMPETRPAGAPRTRLIASYKTLFGNGA 208
Cdd:cd17472 116 NRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 209 FNC-YLLMLIGGLAGIAVFEACSGVLMGAVLGLSSM------VVSILFILPIPAAFfgawFAGRPNKRFSTLMwQSVICC 281
Cdd:cd17472 196 LLRlDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLwkvylpAILIGFILMVPFVI----YAEKKGKMKQVFV-SSILLI 270
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 446751488 282 LLAGLMMwipgWFGVMNVWTLLIPAALFFFGAGMLFPLATS 322
Cdd:cd17472 271 AVGFLLL----LFAATSLWLLIIGLIIFFIGFNLLEALLPS 307
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
22-357 |
3.11e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 58.33 E-value: 3.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 22 MAQTIYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIA 101
Cdd:COG0738 22 FATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 102 ASAMQGMGTGVGGVMARTLPRDLYEGTQlRHANSLLNMGILVSPLLAPLIGGLL---DTLWNWRACYAFLLVLCAGVTFS 178
Cdd:COG0738 102 ALFLLGLGLGLLDVAANPYVAALGPETA-ASRLNLLHAFFSLGALLGPLLGGLLillGLSLSWHLPYLILAVLLLLLALL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 179 MARW-MPETRPAGAPRTRLIASYKTLFGNGAFncyLLMLIGGLAGIAVFEAC---SGVLMGAVLGLSSMVVSILFILPIP 254
Cdd:COG0738 181 FLRSkLPEIEEEEEEAAGSAASLKSLLKNPRL---LLGGLAIFLYVGAEGAIgdwLPLYLKDVLGLSEATAALGLSLFWG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 255 AAFFGAWFAGRPNKRFS---TLMWQSVICCLLAGLMMWIPGwfgvmnVWTLLIPAALFFFGAGMLFPLATSGAMEPFPFL 331
Cdd:COG0738 258 GMTIGRFLGGFLLKRFGpvrLLRLSALLAAVGLLLALLAPG------PWLALIGLALVGLGLSLMFPTIFSLALDGLGKR 331
|
330 340
....*....|....*....|....*.
gi 446751488 332 AGTAGALVGGLQNIGSGVLAWLSAML 357
Cdd:COG0738 332 TAAAVSAVLIMGIVGGAIGPPLIGFL 357
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
26-318 |
3.16e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 57.99 E-value: 3.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 26 IYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIAASAM 105
Cdd:cd17489 14 LLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 106 QGMGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLCAGVTFSMARWMPE 185
Cdd:cd17489 94 HGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 186 TRPAGAPRTRLIASYKTLFGNGAFNCYLLMLIGGLA--GIAVFEAcsgvLMGAVLGLSsmVVSILFILPIPAAFFGAWFA 263
Cdd:cd17489 174 PPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAygAISTFLP----LYAAERGIS--NAGLFFTVYAIALLLSRPFS 247
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 446751488 264 GRPNKRFSTLMwQSVICCLLAGLMMWIpgwFGVM-NVWTLLIPAALFFFGAGMLFP 318
Cdd:cd17489 248 GKLSDRKGPKT-VIIPGLLLLALGLLL---LSFAgSPWMLLLAAVLYGLGFGLLFP 299
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
30-353 |
8.56e-09 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 56.81 E-value: 8.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 30 AIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIAASAMQGMG 109
Cdd:cd17319 25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 110 TGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRacYAFLLVLCAGVTFSMARWMpetrpa 189
Cdd:cd17319 105 EAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWR--WAFIIEGLLGLLLAVLWWF------ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 190 gaprtRLIASYKTLFGNGAFNCYLLMLIGGLAGIavfeacsgvlMGAVLGLSSMVVSILFILPIPAAFFGAWFAGRPNKR 269
Cdd:cd17319 177 -----YLRQVWGLALGYFGINYALYGLLTWLPTY----------LKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 270 FSTL--MWQSVICCLLAGLMMwipgwFGVMNVWTLLIPAALF---FFGAGMLFPLATSGAMEPFPF-LAGTAGALVGGLQ 343
Cdd:cd17319 242 LLRGarRLVIIIGLLLAAVGL-----LLAYLTTSPVVAVILLslaGFGIGAASPVFWSLPADLLPGeAAATAGGLINSGG 316
|
330
....*....|
gi 446751488 344 NIGSGVLAWL 353
Cdd:cd17319 317 NLGGFVAPLL 326
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
21-360 |
4.26e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 54.51 E-value: 4.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 21 QMAQTIYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLI 100
Cdd:cd17504 9 MLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 101 AASAMQgMGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLCAGVTfsma 180
Cdd:cd17504 89 AGRALQ-GIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLA---- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 181 rwmpetrpAGAP--RTRLIASYKTLFGNGAfncYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMVVSILFILPIPAAFF 258
Cdd:cd17504 164 --------ALVPliDLRLLRRRNVLLANIT---ALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLI 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 259 GAWFAGRPNKRFS---TLMWQSVICCLLAGLMMWIPGwfgvmNVWTLLIPAALFFFGAGMLFPLATSGAMEPFPF-LAGT 334
Cdd:cd17504 233 AGPLAGRLIARVGprrVLLIGLVISAVGLLLLALLHS-----SLWALVVALLLIGIGLGLAFASLPNIVVESVPPdRTGI 307
|
330 340
....*....|....*....|....*.
gi 446751488 335 AGALVGGLQNIGSGVLAWLSAMLPQT 360
Cdd:cd17504 308 ATGMNTVLRTIGSAIGPAIAGAILTT 333
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
51-173 |
8.83e-08 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 53.78 E-value: 8.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 51 AYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIAASAMQGMGTGVGGVMArTLPRDLYEGTQL 130
Cdd:cd06179 40 AWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGA-AVASELVPNKYR 118
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 446751488 131 RHANSLLNMGILVSPLLAPLIGGLL--DTLWNWRACYAFLLVLCA 173
Cdd:cd06179 119 GLVQGVVNLVASPGSALGPLIAGALveANAAGWRWIFYINAIFNA 163
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
22-329 |
1.18e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 53.38 E-value: 1.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 22 MAQTIYIPAIADMAQALNVREGAVQSVMAAYlltyGVSQLFY----GPLSDRVGRR-PVILVGMSIFMVATLIAMTTHSL 96
Cdd:cd17490 10 FSQYVYVPFLSPYAESLGASLSMIGIILGAY----GISQMLLriplGILSDRIGKRkLFIIIGLLFTVLASLIMILFPSP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 97 TVLI-------AASAMQGMGTGVGGVmartlprdLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRacYAFLL 169
Cdd:cd17490 86 WGLLiarflsgIAAATWVSFTVLYAS--------YFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMR--APFLL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 170 VLCAGVT-FSMARWMPETRPAGAPRTRLIASYKTLFGNGafncyLLMLIGGLAGIAVFEACSGV-----LMGAVLGLSSM 243
Cdd:cd17490 156 AALAGVLgFILSLFIKEERREKKPVLTELKELLSVLKDK-----KLLFFSLLAILQQMITFSTTfgftpLIAKQLGASSF 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 244 ---VVSILFILP-IPAAFFGAWFAGrpnKRFSTLMWQSVICCLLAGLMMWIPGwfgVMNVWTLLIPAALFFFGAGMLFPL 319
Cdd:cd17490 231 qlgLLSIIYLLPnALASLLSGTLFY---KKLGERNTIIIGFLLLGAYCFLIPF---APNLTLLYLLQALNGFGTGILFPL 304
|
330
....*....|
gi 446751488 320 ATSGAMEPFP 329
Cdd:cd17490 305 LMSLSIEGVP 314
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
21-349 |
3.46e-07 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 51.88 E-value: 3.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 21 QMAQTIYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLI 100
Cdd:cd17476 11 QAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 101 AASAMQGMGTGVGGVMARTLPRDLYEGTQLRH-ANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLCAGVtfsm 179
Cdd:cd17476 91 ICRALQGLGPAFLLPNAMALLGRTYPPGPRKNiVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIV---- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 180 arwmpetrpagaprtrLIASYktLFGNGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMVVSILFILPIPAAFFG 259
Cdd:cd17476 167 ----------------AVAAI--FWTSPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 260 AWFAGR--PNKRFSTLMWQSVICCLLAGLMmwipgwFGVMNV----WTLLIPAALFF-FGAGMLFPLAT---SGAMEpfP 329
Cdd:cd17476 229 AITVGFliARLPPSYIMAISMVAFLVGPIL------FATMPVhqtyWAQAFPAMIVApFGMDFSFPAATiiaSNAVP--R 300
|
330 340
....*....|....*....|
gi 446751488 330 FLAGTAGALVGGLQNIGSGV 349
Cdd:cd17476 301 EYQGLAGSLVNTVVNYGISI 320
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
22-351 |
2.93e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 49.10 E-value: 2.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 22 MAQTIYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIA 101
Cdd:COG2807 32 PAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 102 ASAMQGMGTGVGGVMARTLPRDLYeGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLCAGVTFSMAR 181
Cdd:COG2807 112 GTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLP 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 182 WMPEtRPAGAPRTRLIASYKTLFGNGAFncYLLMLIGGLAGIAVFEACS-GVLMGAVLGLSS----MVVSILFILPIPAA 256
Cdd:COG2807 191 LLRR-RPAAAAAAPAAASLRSLWRSPLA--WLLTLFFGLQSLLYYAVVAwLPPILRDAGLSAatagLLLSLFQLAGIPGS 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 257 FFGAWFAGRPNKRFSTLMWQSVICCLLAGLMMWIPGWFgvmnvwtLLIPAALFFFGAGMLFPLATSGAMEPFPfLAGTAG 336
Cdd:COG2807 268 LLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSL-------PWLWAVLLGLGQGGLFPLALTLIGLRAR-TPAEAA 339
|
330
....*....|....*
gi 446751488 337 ALVGGLQNIGSGVLA 351
Cdd:COG2807 340 ALSGMAQSVGYLLAA 354
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
48-357 |
1.73e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.44 E-value: 1.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 48 VMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIAASAMQGMGTGVGGVMARTL----PRD 123
Cdd:cd17316 41 LFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYvaefAPS 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 124 LYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLcAGVTFSMARWMpetrpagaprtrLIASYKTL 203
Cdd:cd17316 121 KRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALP-ALLALLLRRRT------------LLLILLWF 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 204 FGNGAFNCYLLMLIGGLAGIavfeacsgvlMGAVLGLSSMVVSILFILPIPAAFFGAWFAGRPNKRfstlmWQSVICCLL 283
Cdd:cd17316 188 FISFGYYGLTTFLPTYLQTV----------LGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRK-----KTLVIGLIL 252
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446751488 284 AGLMMWIPGWFGVMNVWTLLIPAALFFFGAGMLFPLATSGAMEPFP-FLAGTAGALVGGLQNIGSGVLAWLSAML 357
Cdd:cd17316 253 SGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPtEVRATGVGLSYNLGRLGGGGAPPLIALL 327
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
25-183 |
3.08e-05 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 45.88 E-value: 3.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 25 TIYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIAASA 104
Cdd:PRK10504 27 TIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARV 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446751488 105 MQGMGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRacYAFLLVLCAGVTFSMARWM 183
Cdd:PRK10504 107 LQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWH--WIFLINIPVGIIGAIATLM 183
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
20-317 |
3.47e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 45.68 E-value: 3.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 20 GQMAQTIYIPAIADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLI-----AMTTH 94
Cdd:cd06173 11 SALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVlallaLLGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 95 SLTVLIAASAMQGMGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACY---AFLLVL 171
Cdd:cd06173 91 SLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFainALSFLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 172 CAGVTFSMARWMPETRPAGAPRTRLIASYKTLFGNGAFNCYLLMLIGGLAG--IAVFEACSGVLMGAVLGLSSMVVSILF 249
Cdd:cd06173 171 SALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFAllGGALTVLLPLLAKEVLGGGAAGYGLLL 250
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446751488 250 ILPIPAAFFGAWFAGRPNKRFSTLMWqSVICCLLAGLMMWIpgwFGVMNVWTLLIPAALFFFGAGMLF 317
Cdd:cd06173 251 AAFGVGALLGALLLGRLSKRRRRGRL-LLIGALLLGLALLV---LGLSPSLWLLLAALFLLGLAGGLF 314
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
31-361 |
1.71e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 43.46 E-value: 1.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 31 IADMAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIAASAMQGMGT 110
Cdd:cd17333 19 GPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 111 GVGGVMARTLPRDLYEGTQ---LRHANSLLNMGILVSPLlapLIGGLLDTLWNWRACY--AFLLVLCAGVTFSMARWMPe 185
Cdd:cd17333 99 GILDTGANTFVGALFEESSatrLNVLHGFFGLGALIGPL---IATSLLTSELSWSWAYliIGLIYLLLAILILLTLFPE- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 186 tRPAGAPRTRLIASYKTLFGNGAFNCYLLM-----LIGGLAGIAVFEACSGVLMGAVL---GLSSMVVSILFILPIPAAF 257
Cdd:cd17333 175 -LPSARNPQQSVGAFSASASRLLRNPSIILgalalFLYVGAETAFSSWVPSYLVEKKHvsdGLAGYLLSGFWVGITIGRL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 258 FGAWFAGRpnKRFSTLMWQSVICCLLAGLMMWIPGWFGVMNVWTLLIpaalfFFGAGMLFPLATSGAMEPFPFLAGTAGA 337
Cdd:cd17333 254 LGGPISRR--IKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALL-----GLFMAALFPTILSLGISNLPYAKGKGTS 326
|
330 340
....*....|....*....|....
gi 446751488 338 LVGGLQNIGSGVLAWLSAMLPQTG 361
Cdd:cd17333 327 VLLAAGSIGGAIIPFIMGFIAEAV 350
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
48-187 |
2.31e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 42.93 E-value: 2.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 48 VMAAYLLTYGVSQLFYGPLSDRVGRR--PVILVGMSIFMVATLIAMTTHSLTVLIAASAMQGMGTGVGGVMARTLPRDLY 125
Cdd:COG2271 221 LLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELF 300
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446751488 126 EGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLCAGVTFSMARWMPETR 187
Cdd:COG2271 301 PKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
146-317 |
3.18e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 42.45 E-value: 3.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 146 LLAPLIGGLLDTLWNWRACYAFLLVLCAGVTFSMARWMPETRPAGAPRT---------RLIASYKTLFGNGAFNCYLL-- 214
Cdd:COG2270 168 FLKPEAFGLPDAGEAVRISFLLTALWWLLFALPLFLFLPERPRPGPAPPrgavragfrELRRTLRELRRYRDLLRFLLay 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 215 -MLIGGLAGIAVFeacSGVLMGAVLGLSSMVVSILFILPIPAAFFGAWFAGRPNKRFSTLMwqsvicCLLAGLMMWIpgw 293
Cdd:COG2270 248 fFYRDGVQTVIAF---AGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKR------VILVSLVIWI--- 315
|
170 180
....*....|....*....|....
gi 446751488 294 fgVMNVWTLLIPAALFFFGAGMLF 317
Cdd:COG2270 316 --VVCLAAYFLTTALAFWILGLLI 337
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
48-357 |
1.25e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 40.44 E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 48 VMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIAASAMQGMGTGVGGVMARTLPRDLYEG 127
Cdd:TIGR00881 35 LLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSR 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 128 TQLRHANSLLNMGILVS-PLLAPLIGGLLDTLWNWRACYAFLLVLCAGVTF----------------SMARWMPETRPAG 190
Cdd:TIGR00881 115 SERGTWVSFWNCSHNVGgGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLicflllrdspqscglpPAEEMPNEEPDGD 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 191 APRTRLIASYKTLFGNGAFNCYLLMLIGgLAGIAVFEACSGVL------MGAVLGLSSMVVSILFILPIPAAFFGAWFAG 264
Cdd:TIGR00881 195 AEKKEEELTKKQIFLQYVLLNKVLWYIS-LGYVFVYVVRTGILdwsplyLTQEKGFSKEKASWAFTLYELGGLVGTLLAG 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 265 ------RPNKRFSTLM-WQSVICCLLAGLMMWIPGWFGVMNVwtLLIPAALFFFGAGMLFPLATSGAMepFPFLAGTAGA 337
Cdd:TIGR00881 274 wlsdklFNGRRGPLAVfFMALIIVSLLVYWLNPAANPLMDLI--CLFALGFLVYGPQMLIGVIASELA--PKKAAGTAAG 349
|
330 340
....*....|....*....|
gi 446751488 338 LVGGLQNIGSGVLAWLSAML 357
Cdd:TIGR00881 350 FVGFFAYLGGILAGLPLGYL 369
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
35-177 |
3.32e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.45 E-value: 3.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 35 AQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIAASAMQGMGTGVGG 114
Cdd:cd17370 226 AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQE 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446751488 115 VMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRA--CYAFLLVLCAGVTF 177
Cdd:cd17370 306 SIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAafLFSAVLALIALLLL 370
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
34-185 |
3.47e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 39.26 E-value: 3.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 34 MAQALNVREGAVQSVMAAYLLTYGVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIAASAMQGMGTGVG 113
Cdd:TIGR00895 43 ISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGL 122
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446751488 114 GVMARTLPRDlYEGTQLR-HANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLCAGVTFSMARWMPE 185
Cdd:TIGR00895 123 MPNLNALVSE-YAPKRFRgTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPE 194
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
57-182 |
4.67e-03 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 39.27 E-value: 4.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 57 GVSQLFYGPLSDRVGRRPVILVGMSIFMVATLIAMTTHSLTVLIAASAMqgmgTGVGGVMARTLPrdLYEGTQLRHANSL 136
Cdd:pfam06609 92 AVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTL----LGVAAGPAGASP--LFIGELMSNKTKF 165
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 446751488 137 LNMGILVSPLLA-----PLIGGLLDTLWNWRACYAFLLVLCAGVTFSMARW 182
Cdd:pfam06609 166 LGLLIVSAPTIAmngagPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLIIIW 216
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
22-318 |
6.06e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.33 E-value: 6.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 22 MAQTIYIPAIADMAQALNVREGAvqSVMAAYLL-TYGVSQLFYGP----LSDRVGRRPVILVGMSIFMVATLIAMTTHSL 96
Cdd:cd17330 10 LGFGIVFPVLPFYVREFNKLGAS--GYYVGLLQsSYSLGQFLASPlwgrLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 97 TVLIAASAMQgMGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLDTLWNWRACYAFLLVLCAGVT 176
Cdd:cd17330 88 WLLFLARFLD-GLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 177 FSMARWMPETRpagaprtRLIASYKTLFgngafncyllmligglAGIAVFEACSGVLMGAVLGLSSMVVSILFIL-PIPA 255
Cdd:cd17330 167 VLVLFFLPPLR-------RLLLVYFLIA----------------LAFAGLESVFSLFLKDRFGFSPSQIGLLLALvGIAG 223
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446751488 256 AFFGAWFAGRPNKRFS---TLMWQSVICCLLAGLMMWIPgwfgvmNVWTLLIPAALFFFGAGMLFP 318
Cdd:cd17330 224 ILAQLLLIPRLAKRLGerkLLRLGLLLAIIGLLLLPFAS------SVPLLVLAAAILAFGTGIVFP 283
|
|
| COG4262 |
COG4262 |
Predicted spermidine synthase with an N-terminal membrane domain [General function prediction ... |
212-342 |
6.25e-03 |
|
Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only];
Pssm-ID: 443404 [Multi-domain] Cd Length: 426 Bit Score: 38.31 E-value: 6.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446751488 212 YLLMLIGGLAGIA---VFEACSGVLMG-AVLGLSSMVVSILFILPIpAAFFGAWFAGRPNKRFSTL-MWQSVICCLLAGL 286
Cdd:COG4262 13 LLAVFVVGACGLVyelLLGRLASYLLGdSVLQFSIVIGVFLFAMGL-GSYLSRRVADRLLRAFIRLeLLLALLGGLSALL 91
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446751488 287 MMWIPGWFGVMNVWTLLI-PAALFFFGAGMLFPLATSGAMEPFPFL---------AGTAGALVGGL 342
Cdd:COG4262 92 LFALFAFLLGALFLLALYlLVLLIGLLIGAEIPLLMRLLERRREELgsavgrvyaADYLGALVGSL 157
|
|
| |
