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Conserved domains on  [gi|446749247|ref|WP_000826503|]
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MULTISPECIES: YfeC-like transcriptional regulator [Enterobacteriaceae]

Protein Classification

MerR family transcriptional regulator( domain architecture ID 10537132)

MerR family transcriptional regulator activates transcription through protein-dependent DNA distortion and the majority of regulators in the family respond to environmental stimuli, such as oxidative stress, heavy metals or antibiotics

CATH:  1.10.10.10
Gene Ontology:  GO:0003677|GO:0003700|GO:0006355
PubMed:  2644244|15808743|12829265|17302809|35130613
SCOP:  3000158

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF1323 pfam07037
Putative transcription regulator (DUF1323); This family consists of several hypothetical ...
 8-129 6.80e-75

Putative transcription regulator (DUF1323); This family consists of several hypothetical Enterobacterial proteins of around 120 residues in length. This family appears to have an HTH domain and is therefore likely to act as a transcriptional regulator.


:

Pssm-ID: 399786  Cd Length: 122  Bit Score: 218.19  E-value: 6.80e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749247    8 MTTEELAECLGVAKQTVNRWIREKGWKTEKFPGVKGGRARLILVDTQVCEFIQNTPAFHNTPMLMEAEERIAEYAPGARA 87
Cdd:pfam07037   1 MTPEELAECLGYARQTINRWVREEGWRTEPFPGVKGGRARLVHVDEQVREFIRNAPAFRNLLTDNRAAESPAEYAPNERA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 446749247   88 PAYRQIINAIDNMTDIEQEKVAQFLSREGIRNFLARLDIDES 129
Cdd:pfam07037  81 PLERQIITLAKEMTPSEQKQLASLLSREGIRGFLARLGIRDS 122
 
Name Accession Description Interval E-value
DUF1323 pfam07037
Putative transcription regulator (DUF1323); This family consists of several hypothetical ...
 8-129 6.80e-75

Putative transcription regulator (DUF1323); This family consists of several hypothetical Enterobacterial proteins of around 120 residues in length. This family appears to have an HTH domain and is therefore likely to act as a transcriptional regulator.


Pssm-ID: 399786  Cd Length: 122  Bit Score: 218.19  E-value: 6.80e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749247    8 MTTEELAECLGVAKQTVNRWIREKGWKTEKFPGVKGGRARLILVDTQVCEFIQNTPAFHNTPMLMEAEERIAEYAPGARA 87
Cdd:pfam07037   1 MTPEELAECLGYARQTINRWVREEGWRTEPFPGVKGGRARLVHVDEQVREFIRNAPAFRNLLTDNRAAESPAEYAPNERA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 446749247   88 PAYRQIINAIDNMTDIEQEKVAQFLSREGIRNFLARLDIDES 129
Cdd:pfam07037  81 PLERQIITLAKEMTPSEQKQLASLLSREGIRGFLARLGIRDS 122
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
3-32 2.51e-04

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 36.75  E-value: 2.51e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 446749247   3 RLRNKMTTEELAECLGVAKQTVNRWirEKG 32
Cdd:COG1476   13 RKERGLTQEELAELLGVSRQTISAI--ENG 40
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 3-31 6.01e-04

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 35.61  E-value: 6.01e-04
                         10        20
                 ....*....|....*....|....*....
gi 446749247   3 RLRNKMTTEELAECLGVAKQTVNRWIREK 31
Cdd:cd00093    8 RKEKGLTQEELAEKLGVSRSTISRIENGK 36
excise TIGR01764
DNA binding domain, excisionase family; An excisionase, or Xis protein, is a small protein ...
 8-49 8.65e-04

DNA binding domain, excisionase family; An excisionase, or Xis protein, is a small protein that binds and promotes excisive recombination; it is not enzymatically active. This model represents a number of putative excisionases and related proteins from temperate phage, plasmids, and transposons, as well as DNA binding domains of other proteins, such as a DNA modification methylase. This model identifies mostly small proteins and N-terminal regions of large proteins, but some proteins appear to have two copies. This domain appears similar, in both sequence and predicted secondary structure (PSIPRED) to the MerR family of transcriptional regulators (pfam00376). [Unknown function, General]


Pssm-ID: 200128  Cd Length: 49  Bit Score: 34.88  E-value: 8.65e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 446749247    8 MTTEELAECLGVAKQTVNRWIREKgwkteKFPGVKGGRARLI 49
Cdd:TIGR01764   2 LTVEEAAEYLGVSKSTVYRLIEEG-----ELPAYRVGRHYRI 38
transpos_IS630 NF033545
IS630 family transposase;
1-126 1.73e-03

IS630 family transposase;


Pssm-ID: 468076 [Multi-domain]  Cd Length: 298  Bit Score: 36.85  E-value: 1.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749247   1 MKRLRNK-MTTEELAECLGVAKQTVNRWIREkgWKTEKFPGVK----GGRARLILVDTQVCEFIQntpAFHNTPmlmeae 75
Cdd:NF033545   5 ILLLAAEgLSITEIAERLGVSRSTVYRWLKR--FNEGGLEGLLdkprPGRPRKLLSEQQAELLAL---LLEEPP------ 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446749247  76 eriaEYAPGARAPAYRQIINAIdnmTDIEqekvaqfLSREGIRNFLARLDI 126
Cdd:NF033545  74 ----EGAGHWTLRELAALLEEE---FGVE-------YSRSTVRRLLKRLGL 110
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
3-31 2.83e-03

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 34.03  E-value: 2.83e-03
                           10        20
                   ....*....|....*....|....*....
gi 446749247     3 RLRNKMTTEELAECLGVAKQTVNRWIREK 31
Cdd:smart00530   6 REEKGLTQEELAEKLGVSRSTLSRIENGK 34
 
Name Accession Description Interval E-value
DUF1323 pfam07037
Putative transcription regulator (DUF1323); This family consists of several hypothetical ...
 8-129 6.80e-75

Putative transcription regulator (DUF1323); This family consists of several hypothetical Enterobacterial proteins of around 120 residues in length. This family appears to have an HTH domain and is therefore likely to act as a transcriptional regulator.


Pssm-ID: 399786  Cd Length: 122  Bit Score: 218.19  E-value: 6.80e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749247    8 MTTEELAECLGVAKQTVNRWIREKGWKTEKFPGVKGGRARLILVDTQVCEFIQNTPAFHNTPMLMEAEERIAEYAPGARA 87
Cdd:pfam07037   1 MTPEELAECLGYARQTINRWVREEGWRTEPFPGVKGGRARLVHVDEQVREFIRNAPAFRNLLTDNRAAESPAEYAPNERA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 446749247   88 PAYRQIINAIDNMTDIEQEKVAQFLSREGIRNFLARLDIDES 129
Cdd:pfam07037  81 PLERQIITLAKEMTPSEQKQLASLLSREGIRGFLARLGIRDS 122
HTH_17 pfam12728
Helix-turn-helix domain; This domain is a DNA-binding helix-turn-helix domain.
 8-49 1.75e-06

Helix-turn-helix domain; This domain is a DNA-binding helix-turn-helix domain.


Pssm-ID: 463684 [Multi-domain]  Cd Length: 51  Bit Score: 42.06  E-value: 1.75e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 446749247    8 MTTEELAECLGVAKQTVNRWIREKgwkteKFPGVKGGRARLI 49
Cdd:pfam12728   2 LTVEEAAELLGVSRRTVYRLIRSG-----ELPAAKIGRRWRI 38
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
3-32 2.51e-04

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 36.75  E-value: 2.51e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 446749247   3 RLRNKMTTEELAECLGVAKQTVNRWirEKG 32
Cdd:COG1476   13 RKERGLTQEELAELLGVSRQTISAI--ENG 40
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 3-31 6.01e-04

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 35.61  E-value: 6.01e-04
                         10        20
                 ....*....|....*....|....*....
gi 446749247   3 RLRNKMTTEELAECLGVAKQTVNRWIREK 31
Cdd:cd00093    8 RKEKGLTQEELAEKLGVSRSTISRIENGK 36
excise TIGR01764
DNA binding domain, excisionase family; An excisionase, or Xis protein, is a small protein ...
 8-49 8.65e-04

DNA binding domain, excisionase family; An excisionase, or Xis protein, is a small protein that binds and promotes excisive recombination; it is not enzymatically active. This model represents a number of putative excisionases and related proteins from temperate phage, plasmids, and transposons, as well as DNA binding domains of other proteins, such as a DNA modification methylase. This model identifies mostly small proteins and N-terminal regions of large proteins, but some proteins appear to have two copies. This domain appears similar, in both sequence and predicted secondary structure (PSIPRED) to the MerR family of transcriptional regulators (pfam00376). [Unknown function, General]


Pssm-ID: 200128  Cd Length: 49  Bit Score: 34.88  E-value: 8.65e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 446749247    8 MTTEELAECLGVAKQTVNRWIREKgwkteKFPGVKGGRARLI 49
Cdd:TIGR01764   2 LTVEEAAEYLGVSKSTVYRLIEEG-----ELPAYRVGRHYRI 38
transpos_IS630 NF033545
IS630 family transposase;
1-126 1.73e-03

IS630 family transposase;


Pssm-ID: 468076 [Multi-domain]  Cd Length: 298  Bit Score: 36.85  E-value: 1.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446749247   1 MKRLRNK-MTTEELAECLGVAKQTVNRWIREkgWKTEKFPGVK----GGRARLILVDTQVCEFIQntpAFHNTPmlmeae 75
Cdd:NF033545   5 ILLLAAEgLSITEIAERLGVSRSTVYRWLKR--FNEGGLEGLLdkprPGRPRKLLSEQQAELLAL---LLEEPP------ 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446749247  76 eriaEYAPGARAPAYRQIINAIdnmTDIEqekvaqfLSREGIRNFLARLDI 126
Cdd:NF033545  74 ----EGAGHWTLRELAALLEEE---FGVE-------YSRSTVRRLLKRLGL 110
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
3-31 2.83e-03

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 34.03  E-value: 2.83e-03
                           10        20
                   ....*....|....*....|....*....
gi 446749247     3 RLRNKMTTEELAECLGVAKQTVNRWIREK 31
Cdd:smart00530   6 REEKGLTQEELAEKLGVSRSTLSRIENGK 34
HTH_23 pfam13384
Homeodomain-like domain;
1-42 5.69e-03

Homeodomain-like domain;


Pssm-ID: 433164 [Multi-domain]  Cd Length: 50  Bit Score: 33.01  E-value: 5.69e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 446749247    1 MKRLRNKMTTEELAECLGVAKQTVNRWIREkgWKTEKFPGVK 42
Cdd:pfam13384  11 LLLLAEGLSVKEIAELLGVSRRTVYRWLKR--YNEEGLEGLL 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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