|
Name |
Accession |
Description |
Interval |
E-value |
| LdcC |
COG1982 |
Arginine/lysine/ornithine decarboxylase [Amino acid transport and metabolism]; |
1-445 |
1.20e-101 |
|
Arginine/lysine/ornithine decarboxylase [Amino acid transport and metabolism];
Pssm-ID: 441585 [Multi-domain] Cd Length: 486 Bit Score: 311.66 E-value: 1.20e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 1 MKQPILNKLESLNQEEAISLHVPGHKNmTIGHLSQLS-------MTMDKTEIPGLDDLHHPEEVILESMKQVEK--HSDY 71
Cdd:COG1982 5 LLTPLFDALKKYAERGPVSFHVPGHKG-GRGFGREFYdffgenvFRLDLTELPGLDDLHDPEGVIKEAQELAAEafGADR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 72 dAYFLVNGTTSGILSVIQSfSQKKGD-ILMARNVHKSVLHALDISQQEGHFIETHQSPLTN-----HYNKVNLSRLNNDG 145
Cdd:COG1982 84 -TFFLVNGTSSGNKAMILA-VCGPGDkVLVPRNCHKSVIHGLILSGAIPVYLNPEIDNELGiiggiTPEAVEEALIEHPD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 146 HKLAVLTYPNYYGETFNVEEVIKSLHQLNIPVLIDEAHGAHFGL-QGFPDSTLNYQADYVVQSFHKTLPALTMGSVLYIH 224
Cdd:COG1982 162 AKAVLITNPTYYGVCYDLKAIAELAHEHGIPVLVDEAHGAHFGFhPDLPRSAMEAGADLVVQSTHKTLGALTQSSMLHVK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 225 KNAPYRETIIEYLSYFQTSSPSYLIMASLESAAEFYKTY---------DSTVFFDKRAQLI--------ECLEKKGFEML 287
Cdd:COG1982 242 GGRVDHERVNEALMLLQSTSPSYLLMASLDVARRQMAGEgeelldealELAIEARKEINKIpglyvfgpEDLGAPGVYDL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 288 qvdDPLKLLI--KYEGFTGHDIQNWFM-NAHIYLELADDYQALAILPLWHHDDTylFDSL---LRKIEDMILPKKSVSKV 361
Cdd:COG1982 322 ---DPTKLTIdvPGLGISGYEVAEYLReEYGIQVELADLYNILFLLSLGDTKED--IERLvaaLKELKRLYDKNAPLEEV 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 362 KQTQLLTT--------EGNYKPKRfeyvtWCDLKKAKGKVLARHIVPYPPGIPIIFKGETITENMIELVNEYLETGMIVE 433
Cdd:COG1982 397 LPLAFPPLpelvmsprEAFFAETE-----LVPLEEAVGRIAAEMVIPYPPGIPLLMPGERITEEVIDYLRALEEAGGRFP 471
|
490
....*....|....*
gi 446735576 434 GIKN---NKILVEDE 445
Cdd:COG1982 472 GFEDpelRTIRVVKE 486
|
|
| Orn_deC_like |
cd00615 |
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
4-264 |
8.47e-84 |
|
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine decarboxylase (LDC). ODC is a dodecamer composed of six homodimers and catalyzes the decarboxylation of tryptophan. ADC catalyzes the decarboxylation of arginine and LDC catalyzes the decarboxylation of lysine. Members of this family are widely found in all three forms of life.
Pssm-ID: 99739 [Multi-domain] Cd Length: 294 Bit Score: 259.10 E-value: 8.47e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 4 PILNKLESLNQEEAISLHVPGHKNMTIGH------LSQLSMTMDKTEIPGLDDLHHPEEVILESMKQVEKH-SDYDAYFL 76
Cdd:cd00615 1 PLFEALKEYAKRGIISFHVPGHKGGRGFRksfyefYGENLFKADVTELTGLDDLLDPTGPIKEAQELAARAfGAKHTFFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 77 VNGTTSGILSVIQSFSQKKGDILMARNVHKSVLHALDISQQEGHFIETHQSPLTNHYNKVNLSR-----LNNDGHKLAVL 151
Cdd:cd00615 81 VNGTSSSNKAVILAVCGPGDKILIDRNCHKSVINGLVLSGAVPVYLKPERNPYYGIAGGIPPETfkkalIEHPDAKAAVI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 152 TYPNYYGETFNVEEVIKSLHQLNIPVLIDEAHGAHFGLQG-FPDSTLNYQADYVVQSFHKTLPALTMGSVLYIHKNAPYR 230
Cdd:cd00615 161 TNPTYYGICYNLRKIVEEAHHRGLPVLVDEAHGAHFRFHPiLPSSAAMAGADIVVQSTHKTLPALTQGSMIHVKGDLVNP 240
|
250 260 270
....*....|....*....|....*....|....
gi 446735576 231 ETIIEYLSYFQTSSPSYLIMASLESAAEFYKTYD 264
Cdd:cd00615 241 DRVNEALNLHQSTSPSYLILASLDVARAMMALEG 274
|
|
| OKR_DC_1 |
pfam01276 |
Orn/Lys/Arg decarboxylase, major domain; |
18-332 |
3.90e-48 |
|
Orn/Lys/Arg decarboxylase, major domain;
Pssm-ID: 396025 [Multi-domain] Cd Length: 417 Bit Score: 169.99 E-value: 3.90e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 18 ISLHVPGHKNMTI-----------GHLSQLSMTMD-KTEIPGLDDLHHPEEVILESMKQVEK--HSDyDAYFLVNGTTSG 83
Cdd:pfam01276 16 YTFHCPGHQGGAGfqkhpagrffyDFFGENLLRIDvCIEDVELGDLLDHEGAIKEAQKYAARvfGAD-KSYFVVNGTSGS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 84 ILSVIQSFSQKKGDILMARNVHKSVLHALDISQQEGHFIETHQSPL-------TNHYNKVNLSRL-----NNDGHKLAVL 151
Cdd:pfam01276 95 NKTVGMAVCTPGDTILIDRNCHKSIHHALMLSGATPVYLEPSRNAYgiiggipLHEFQEETLKEAiaevpDAKGPRLAVI 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 152 TYPNYYGETFNVEEVIKSLHQLNIPVLIDEAHGAHFGLQGFPDSTLNYQAD-------YVVQSFHKTLPALTMGSvlYIH 224
Cdd:pfam01276 175 TNPTYDGVLYNAKEIVDTLHHLSDPILFDSAWVGYEQFIPIYADASPMGGEnengpgiFVTQSVHKLLAALSQAS--YIH 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 225 KNAPY---RETIIEYLSYFQTSSPSYLIMASLESAA--------------------------------EFYKTYDSTVFF 269
Cdd:pfam01276 253 KKEGHivnHDRFNEAFMMHATTSPSYPIFASLDVAAkmlegnsgrrlwnecveraiefrkaidtlnncEFFRPWNPEIVD 332
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446735576 270 DKRAQLIECLEK-KGFEMLQVD----DPLKLLI-----------KYEGFTGHDIQNWFMNAHIYLELADDYQALAILPL 332
Cdd:pfam01276 333 GKECWPFHPGETwHGFEGYADNqyflDPCKLTIltpgmdedgeySEFGVPATIVAKWLRENGIVPEKTDLNNILFLFTP 411
|
|
| PRK15399 |
PRK15399 |
lysine decarboxylase; |
73-416 |
9.50e-06 |
|
lysine decarboxylase;
Pssm-ID: 185297 [Multi-domain] Cd Length: 713 Bit Score: 48.20 E-value: 9.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 73 AYFLVNGTTSGIlSVIQSFSQKKGD-ILMARNVHKSVLHALDISQqeghFIETHQSPLTNHYN------KVNLSRlNNDG 145
Cdd:PRK15399 213 SYIVTNGTSTSN-KIVGMYAAPAGStLLIDRNCHKSLAHLLMMSD----VVPIWLKPTRNALGilggipRREFTR-DSIE 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 146 HKL-----------AVLTYPNYYGETFNVEEV-----IKSLHQLNIPVLIDEAHGAHFGLQGFPDSTLNYQADYVVQSFH 209
Cdd:PRK15399 287 EKVaattqaqwpvhAVITNSTYDGLLYNTDWIkqtldVPSIHFDSAWVPYTHFHPIYQGKSGMSGERVPGKVIFETQSTH 366
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 210 KTLPALTMGSVLYIhKNAPYRETIIEYLSYFQTSSPSYLIMASLESAAEF------YKTYDSTV---------------- 267
Cdd:PRK15399 367 KMLAAFSQASLIHI-KGEYDEETFNEAFMMHTSTSPSYPIVASVETAAAMlrgnpgKRLINRSVeralhfrkevqrlree 445
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 268 ----FFD----KRAQLIECLEKK------GFEMLQVD----DPLKLLIKYEGFTGH-DIQNW---------FMNAH-IYL 318
Cdd:PRK15399 446 sdgwFFDiwqpENVDEAECWPVApgeqwhGFKDADADhmflDPVKVTILTPGMDEQgNMSEEgipaalvakFLDERgIVV 525
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 319 ELADDYQAL---------------------------------AILP-LWHHDDTYLFD----SLLRKIEDMI-------- 352
Cdd:PRK15399 526 EKTGPYNLLflfsigidktkamgllrgltefkraydlnlrvkNMLPdLYAEDPDFYRNmriqDLAQGIHKLIrkhdlpgl 605
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446735576 353 -------LPKKSVSKVKQTQLLTtEGNykpkrfeyVTWCDLKKAKGKVLARHIVPYPPGIPIIFKGETITE 416
Cdd:PRK15399 606 mlrafdvLPEMIMTPHQAWQRQI-KGE--------VETVALEQLVGRVSANMILPYPPGVPLLMPGEMITE 667
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LdcC |
COG1982 |
Arginine/lysine/ornithine decarboxylase [Amino acid transport and metabolism]; |
1-445 |
1.20e-101 |
|
Arginine/lysine/ornithine decarboxylase [Amino acid transport and metabolism];
Pssm-ID: 441585 [Multi-domain] Cd Length: 486 Bit Score: 311.66 E-value: 1.20e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 1 MKQPILNKLESLNQEEAISLHVPGHKNmTIGHLSQLS-------MTMDKTEIPGLDDLHHPEEVILESMKQVEK--HSDY 71
Cdd:COG1982 5 LLTPLFDALKKYAERGPVSFHVPGHKG-GRGFGREFYdffgenvFRLDLTELPGLDDLHDPEGVIKEAQELAAEafGADR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 72 dAYFLVNGTTSGILSVIQSfSQKKGD-ILMARNVHKSVLHALDISQQEGHFIETHQSPLTN-----HYNKVNLSRLNNDG 145
Cdd:COG1982 84 -TFFLVNGTSSGNKAMILA-VCGPGDkVLVPRNCHKSVIHGLILSGAIPVYLNPEIDNELGiiggiTPEAVEEALIEHPD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 146 HKLAVLTYPNYYGETFNVEEVIKSLHQLNIPVLIDEAHGAHFGL-QGFPDSTLNYQADYVVQSFHKTLPALTMGSVLYIH 224
Cdd:COG1982 162 AKAVLITNPTYYGVCYDLKAIAELAHEHGIPVLVDEAHGAHFGFhPDLPRSAMEAGADLVVQSTHKTLGALTQSSMLHVK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 225 KNAPYRETIIEYLSYFQTSSPSYLIMASLESAAEFYKTY---------DSTVFFDKRAQLI--------ECLEKKGFEML 287
Cdd:COG1982 242 GGRVDHERVNEALMLLQSTSPSYLLMASLDVARRQMAGEgeelldealELAIEARKEINKIpglyvfgpEDLGAPGVYDL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 288 qvdDPLKLLI--KYEGFTGHDIQNWFM-NAHIYLELADDYQALAILPLWHHDDTylFDSL---LRKIEDMILPKKSVSKV 361
Cdd:COG1982 322 ---DPTKLTIdvPGLGISGYEVAEYLReEYGIQVELADLYNILFLLSLGDTKED--IERLvaaLKELKRLYDKNAPLEEV 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 362 KQTQLLTT--------EGNYKPKRfeyvtWCDLKKAKGKVLARHIVPYPPGIPIIFKGETITENMIELVNEYLETGMIVE 433
Cdd:COG1982 397 LPLAFPPLpelvmsprEAFFAETE-----LVPLEEAVGRIAAEMVIPYPPGIPLLMPGERITEEVIDYLRALEEAGGRFP 471
|
490
....*....|....*
gi 446735576 434 GIKN---NKILVEDE 445
Cdd:COG1982 472 GFEDpelRTIRVVKE 486
|
|
| Orn_deC_like |
cd00615 |
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
4-264 |
8.47e-84 |
|
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine decarboxylase (LDC). ODC is a dodecamer composed of six homodimers and catalyzes the decarboxylation of tryptophan. ADC catalyzes the decarboxylation of arginine and LDC catalyzes the decarboxylation of lysine. Members of this family are widely found in all three forms of life.
Pssm-ID: 99739 [Multi-domain] Cd Length: 294 Bit Score: 259.10 E-value: 8.47e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 4 PILNKLESLNQEEAISLHVPGHKNMTIGH------LSQLSMTMDKTEIPGLDDLHHPEEVILESMKQVEKH-SDYDAYFL 76
Cdd:cd00615 1 PLFEALKEYAKRGIISFHVPGHKGGRGFRksfyefYGENLFKADVTELTGLDDLLDPTGPIKEAQELAARAfGAKHTFFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 77 VNGTTSGILSVIQSFSQKKGDILMARNVHKSVLHALDISQQEGHFIETHQSPLTNHYNKVNLSR-----LNNDGHKLAVL 151
Cdd:cd00615 81 VNGTSSSNKAVILAVCGPGDKILIDRNCHKSVINGLVLSGAVPVYLKPERNPYYGIAGGIPPETfkkalIEHPDAKAAVI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 152 TYPNYYGETFNVEEVIKSLHQLNIPVLIDEAHGAHFGLQG-FPDSTLNYQADYVVQSFHKTLPALTMGSVLYIHKNAPYR 230
Cdd:cd00615 161 TNPTYYGICYNLRKIVEEAHHRGLPVLVDEAHGAHFRFHPiLPSSAAMAGADIVVQSTHKTLPALTQGSMIHVKGDLVNP 240
|
250 260 270
....*....|....*....|....*....|....
gi 446735576 231 ETIIEYLSYFQTSSPSYLIMASLESAAEFYKTYD 264
Cdd:cd00615 241 DRVNEALNLHQSTSPSYLILASLDVARAMMALEG 274
|
|
| OKR_DC_1 |
pfam01276 |
Orn/Lys/Arg decarboxylase, major domain; |
18-332 |
3.90e-48 |
|
Orn/Lys/Arg decarboxylase, major domain;
Pssm-ID: 396025 [Multi-domain] Cd Length: 417 Bit Score: 169.99 E-value: 3.90e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 18 ISLHVPGHKNMTI-----------GHLSQLSMTMD-KTEIPGLDDLHHPEEVILESMKQVEK--HSDyDAYFLVNGTTSG 83
Cdd:pfam01276 16 YTFHCPGHQGGAGfqkhpagrffyDFFGENLLRIDvCIEDVELGDLLDHEGAIKEAQKYAARvfGAD-KSYFVVNGTSGS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 84 ILSVIQSFSQKKGDILMARNVHKSVLHALDISQQEGHFIETHQSPL-------TNHYNKVNLSRL-----NNDGHKLAVL 151
Cdd:pfam01276 95 NKTVGMAVCTPGDTILIDRNCHKSIHHALMLSGATPVYLEPSRNAYgiiggipLHEFQEETLKEAiaevpDAKGPRLAVI 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 152 TYPNYYGETFNVEEVIKSLHQLNIPVLIDEAHGAHFGLQGFPDSTLNYQAD-------YVVQSFHKTLPALTMGSvlYIH 224
Cdd:pfam01276 175 TNPTYDGVLYNAKEIVDTLHHLSDPILFDSAWVGYEQFIPIYADASPMGGEnengpgiFVTQSVHKLLAALSQAS--YIH 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 225 KNAPY---RETIIEYLSYFQTSSPSYLIMASLESAA--------------------------------EFYKTYDSTVFF 269
Cdd:pfam01276 253 KKEGHivnHDRFNEAFMMHATTSPSYPIFASLDVAAkmlegnsgrrlwnecveraiefrkaidtlnncEFFRPWNPEIVD 332
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446735576 270 DKRAQLIECLEK-KGFEMLQVD----DPLKLLI-----------KYEGFTGHDIQNWFMNAHIYLELADDYQALAILPL 332
Cdd:pfam01276 333 GKECWPFHPGETwHGFEGYADNqyflDPCKLTIltpgmdedgeySEFGVPATIVAKWLRENGIVPEKTDLNNILFLFTP 411
|
|
| PRK15399 |
PRK15399 |
lysine decarboxylase; |
73-416 |
9.50e-06 |
|
lysine decarboxylase;
Pssm-ID: 185297 [Multi-domain] Cd Length: 713 Bit Score: 48.20 E-value: 9.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 73 AYFLVNGTTSGIlSVIQSFSQKKGD-ILMARNVHKSVLHALDISQqeghFIETHQSPLTNHYN------KVNLSRlNNDG 145
Cdd:PRK15399 213 SYIVTNGTSTSN-KIVGMYAAPAGStLLIDRNCHKSLAHLLMMSD----VVPIWLKPTRNALGilggipRREFTR-DSIE 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 146 HKL-----------AVLTYPNYYGETFNVEEV-----IKSLHQLNIPVLIDEAHGAHFGLQGFPDSTLNYQADYVVQSFH 209
Cdd:PRK15399 287 EKVaattqaqwpvhAVITNSTYDGLLYNTDWIkqtldVPSIHFDSAWVPYTHFHPIYQGKSGMSGERVPGKVIFETQSTH 366
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 210 KTLPALTMGSVLYIhKNAPYRETIIEYLSYFQTSSPSYLIMASLESAAEF------YKTYDSTV---------------- 267
Cdd:PRK15399 367 KMLAAFSQASLIHI-KGEYDEETFNEAFMMHTSTSPSYPIVASVETAAAMlrgnpgKRLINRSVeralhfrkevqrlree 445
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 268 ----FFD----KRAQLIECLEKK------GFEMLQVD----DPLKLLIKYEGFTGH-DIQNW---------FMNAH-IYL 318
Cdd:PRK15399 446 sdgwFFDiwqpENVDEAECWPVApgeqwhGFKDADADhmflDPVKVTILTPGMDEQgNMSEEgipaalvakFLDERgIVV 525
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 319 ELADDYQAL---------------------------------AILP-LWHHDDTYLFD----SLLRKIEDMI-------- 352
Cdd:PRK15399 526 EKTGPYNLLflfsigidktkamgllrgltefkraydlnlrvkNMLPdLYAEDPDFYRNmriqDLAQGIHKLIrkhdlpgl 605
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446735576 353 -------LPKKSVSKVKQTQLLTtEGNykpkrfeyVTWCDLKKAKGKVLARHIVPYPPGIPIIFKGETITE 416
Cdd:PRK15399 606 mlrafdvLPEMIMTPHQAWQRQI-KGE--------VETVALEQLVGRVSANMILPYPPGVPLLMPGEMITE 667
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
78-287 |
2.14e-05 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 46.53 E-value: 2.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 78 NGTTSGILSVIQSFSQKKGDILMARNVHKSVLHALDISQQEGHFIETHQSPlTNHYNKVNLSRLNNDGHKLAVLTYP-NY 156
Cdd:pfam00155 70 SGAGANIEALIFLLANPGDAILVPAPTYASYIRIARLAGGEVVRYPLYDSN-DFHLDFDALEAALKEKPKVVLHTSPhNP 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 157 YGETFN---VEEVIKSLHQLNIPVLIDEAHGAH-FGLQGFPDSTLN---YQADYVVQSFHKT--LPALTMGSVLyihkna 227
Cdd:pfam00155 149 TGTVATleeLEKLLDLAKEHNILLLVDEAYAGFvFGSPDAVATRALlaeGPNLLVVGSFSKAfgLAGWRVGYIL------ 222
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446735576 228 pYRETIIEYL------SYFQTSSPSYLImASLESAAEFYKTYDSTV--FFDKRAQLIECLEKKGFEML 287
Cdd:pfam00155 223 -GNAAVISQLrklarpFYSSTHLQAAAA-AALSDPLLVASELEEMRqrIKERRDYLRDGLQAAGLSVL 288
|
|
| CsdA |
COG0520 |
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism]; |
76-225 |
4.19e-05 |
|
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
Pssm-ID: 440286 [Multi-domain] Cd Length: 396 Bit Score: 45.52 E-value: 4.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 76 LVNGTTSGILSVIQSFSQ-KKGD-ILMARNVHKSVLHA-LDISQQEGhfIETHQSPLTNHYnKVNLSRLN---NDGHKLA 149
Cdd:COG0520 82 FTRGTTEAINLVAYGLGRlKPGDeILITEMEHHSNIVPwQELAERTG--AEVRVIPLDEDG-ELDLEALEallTPRTKLV 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 150 VLTY-PNYYGETFNVEEVIKSLHQLNIPVLIDeahGAhfglQGFPDSTLNYQA---DYVVQSFHKTL-PaltMGS-VLYI 223
Cdd:COG0520 159 AVTHvSNVTGTVNPVKEIAALAHAHGALVLVD---GA----QSVPHLPVDVQAlgcDFYAFSGHKLYgP---TGIgVLYG 228
|
..
gi 446735576 224 HK 225
Cdd:COG0520 229 KR 230
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
54-223 |
6.42e-05 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 43.53 E-value: 6.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 54 PEEVILESMKQVEKHSDYDAYFlVNGTTSGILSVIQSFSQKKGDILMARNVHKSVLHALDISqqegHFIETHQSPLT-NH 132
Cdd:cd01494 1 KLEELEEKLARLLQPGNDKAVF-VPSGTGANEAALLALLGPGDEVIVDANGHGSRYWVAAEL----AGAKPVPVPVDdAG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 133 YNKVNLS----RLNNDGHKLAVLTYPNY-YGETFNVEEVIKSLHQLNIPVLIDEAHGahFGLQGFP-DSTLNYQADYVVQ 206
Cdd:cd01494 76 YGGLDVAileeLKAKPNVALIVITPNTTsGGVLVPLKEIRKIAKEYGILLLVDAASA--GGASPAPgVLIPEGGADVVTF 153
|
170
....*....|....*..
gi 446735576 207 SFHKTLpALTMGSVLYI 223
Cdd:cd01494 154 SLHKNL-GGEGGGVVIV 169
|
|
| OKR_DC_1_C |
pfam03711 |
Orn/Lys/Arg decarboxylase, C-terminal domain; |
379-416 |
1.23e-04 |
|
Orn/Lys/Arg decarboxylase, C-terminal domain;
Pssm-ID: 461020 [Multi-domain] Cd Length: 132 Bit Score: 41.74 E-value: 1.23e-04
10 20 30
....*....|....*....|....*....|....*...
gi 446735576 379 EYVtwcDLKKAKGKVLARHIVPYPPGIPIIFKGETITE 416
Cdd:pfam03711 64 ELV---PLDELEGRIAAVGVLPYPPGIPLLMPGERFGE 98
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
75-285 |
3.81e-04 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 42.33 E-value: 3.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 75 FLVNGTTSGILSVIQSFSQKKGDILMAR---NVHKSVLHALDIsqqeghfiETHQSPLTNHYNKVN----LSRLNNDGHK 147
Cdd:cd00609 63 VVTNGAQEALSLLLRALLNPGDEVLVPDptyPGYEAAARLAGA--------EVVPVPLDEEGGFLLdlelLEAAKTPKTK 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 148 LAVLTYPNY-YGETFNVEE---VIKSLHQLNIPVLIDEAHGaHFGLQGFPDSTLNYQADY----VVQSFHKT--LPALTM 217
Cdd:cd00609 135 LLYLNNPNNpTGAVLSEEEleeLAELAKKHGILIISDEAYA-ELVYDGEPPPALALLDAYerviVLRSFSKTfgLPGLRI 213
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446735576 218 GsvlYIH-KNAPYRETIIEYLSYFQTSSPS---YLIMASLESAAEFYKTYdSTVFFDKRAQLIECLEKKGFE 285
Cdd:cd00609 214 G---YLIaPPEELLERLKKLLPYTTSGPSTlsqAAAAAALDDGEEHLEEL-RERYRRRRDALLEALKELGPL 281
|
|
| SepCysS |
cd06452 |
Sep-tRNA:Cys-tRNA synthase. This family belongs to the pyridoxal phosphate (PLP)-dependent ... |
147-214 |
1.41e-03 |
|
Sep-tRNA:Cys-tRNA synthase. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Cys-tRNA(Cys) is produced by O-phosphoseryl-tRNA synthetase which ligates O-phosphoserine (Sep) to tRNA(Cys), and Sep-tRNA:Cys-tRNA synthase (SepCysS) converts Sep-tRNA(Cys) to Cys-tRNA(Cys), in methanogenic archaea. SepCysS forms a dimer, each monomer is composed of a large and small domain; the larger, a typical pyridoxal 5'-phosphate (PLP)-dependent-like enzyme fold. In the active site of each monomer, PLP is covalently bound to a conserved Lys residue near the dimer interface.
Pssm-ID: 99745 Cd Length: 361 Bit Score: 40.84 E-value: 1.41e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446735576 147 KLAVLTYPNY-YGETFNVEEVIKSLHQLNIPVLIDEAhgahFGLQGFPDSTLNYQADYVVQSFHKTLPA 214
Cdd:cd06452 141 ALALLTHVDGnYGNLHDAKKIAKVCHEYGVPLLLNGA----YTVGRMPVSGKELGADFIVGSGHKSMAA 205
|
|
| PRK15400 |
PRK15400 |
lysine decarboxylase; |
73-416 |
1.66e-03 |
|
lysine decarboxylase;
Pssm-ID: 185298 [Multi-domain] Cd Length: 714 Bit Score: 40.99 E-value: 1.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 73 AYFLVNGTTSGIlSVIQSFSQKKGD-ILMARNVHKSVLHALDISQqeghFIETHQSPLTNHYN------KVNLSRL---- 141
Cdd:PRK15400 213 SYMVTNGTSTAN-KIVGMYSAPAGStVLIDRNCHKSLTHLMMMSD----VTPIYFRPTRNAYGilggipQSEFQHAtiak 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 142 ------NNDGHKLAVLTYPNYYGETFNVEEV-----IKSLHQLNIPVLIDEAHGAHFGLQGFPDSTLNYQADYVVQSFHK 210
Cdd:PRK15400 288 rvketpNATWPVHAVITNSTYDGLLYNTDFIkktldVKSIHFDSAWVPYTNFSPIYEGKCGMSGGRVEGKVIYETQSTHK 367
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 211 TLPALTMGSVLYIhKNAPYRETIIEYLSYFQTSSPSYLIMASLESAAEFYK----------TYDSTVFFDKRAQLIEClE 280
Cdd:PRK15400 368 LLAAFSQASMIHV-KGDVNEETFNEAYMMHTTTSPHYGIVASTETAAAMMKgnagkrlingSIERAIKFRKEIKRLRT-E 445
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 281 KKG--FEMLQVDD-------PLKLLIKYEGFTGHDiqnwfmNAHIYLelaDDYQALAILPLWHHDDTYLFD----SLLRK 347
Cdd:PRK15400 446 SDGwfFDVWQPDHidttecwPLRSDSTWHGFKNID------NEHMYL---DPIKVTLLTPGMKKDGTMSDFgipaSIVAK 516
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446735576 348 I--EDMILPKKS------------VSKVKQTQLLTTEGNYK--------------------PKRFE-------------- 379
Cdd:PRK15400 517 YldEHGIVVEKTgpynllflfsigIDKTKALSLLRALTDFKrafdlnlrvknmlpslyredPEFYEnmriqelaqnihkl 596
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446735576 380 ------------------------YVTW----------CDLKKAKGKVLARHIVPYPPGIPIIFKGETITE 416
Cdd:PRK15400 597 ivhhnlpdlmyrafevlptmvmtpYAAFqkelhgmteeVYLDEMVGRVNANMILPYPPGVPLVMPGEMITE 667
|
|
| PRK09331 |
PRK09331 |
Sep-tRNA:Cys-tRNA synthetase; Provisional |
147-214 |
6.47e-03 |
|
Sep-tRNA:Cys-tRNA synthetase; Provisional
Pssm-ID: 236469 Cd Length: 387 Bit Score: 38.76 E-value: 6.47e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446735576 147 KLAVLTYPNY-YGETFNVEEVIKSLHQLNIPVLIDEAHGAhfGLQGFPDSTLNyqADYVVQSFHKTLPA 214
Cdd:PRK09331 160 ALALLTHVDGnYGNLADAKKVAKVAHEYGIPFLLNGAYTV--GRMPVDGKKLG--ADFIVGSGHKSMAA 224
|
|
| |
