|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
24-461 |
1.78e-137 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 402.22 E-value: 1.78e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 24 IWKSMSMFLVPLLLSNVLQSVGQLFGMVVVGRWLGVNDLAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGAKNEDRLK 103
Cdd:cd13138 1 ILKTLLLFALPLLLSNLLQQLYNLVDLLIVGQFLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 104 AIVGTTLTFTFIIGVVLAIIGSIFAMDIMRLMGTPENIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFYFLI 183
Cdd:cd13138 81 KAVGTLLVLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFVI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 184 VSTALNMILLPILIFGwlgaPKLDVYGAAYASVISTVITFIVMLLYLKKKNHPLQLDgtvRKYLRMDGELLKLLLRLGIP 263
Cdd:cd13138 161 IACVLNIILDLLFIAV----FHMGVAGAALATVIAQAISVLLALYYLRKKKLPFKLS---LKDFRFDKEILKEILKIGLP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 264 ASINMILVSLSEIAVIAFVNRYGSDATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGIIMNYV 343
Cdd:cd13138 234 SALQQSLVSISFLIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLI 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 344 IGGVLISLIYLFSRDILSLFLTSQTTIEIAHSLVMITLWSYLIFGHAQIISATMRASGTVLWPTVIGVVSIWLVEVPVAY 423
Cdd:cd13138 314 IGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLAY 393
|
410 420 430
....*....|....*....|....*....|....*...
gi 446726807 424 YLSYHTSLGIEGIWIGYPAAFIVSLILQYAYYKLSWQK 461
Cdd:cd13138 394 LLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRWK 431
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
21-454 |
1.01e-103 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 315.93 E-value: 1.01e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 21 SKPIWKSMSMFLVPLLLSNVLQSVGQLFGMVVVGRwLGVNDLAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGAKNED 100
Cdd:COG0534 3 EGPILKLLLRLALPIILGNLLQSLYGLVDTIFVGR-LGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDRE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 101 RLKAIVGTTLTFTFIIGVVLAIIGSIFAMDIMRLMGTPENIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFY 180
Cdd:COG0534 82 EARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 181 FLIVSTALNMILLPILIFGwlgaPKLDVYGAAYASVISTVITFIVMLLYLKKKNHPLQLDgtvRKYLRMDGELLKLLLRL 260
Cdd:COG0534 162 IMLIGNVLNIVLDPLLIFG----GGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLR---LRDLRPDRKILKRILRI 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 261 GIPASINMILVSLSEIAVIAFVNRYGSDATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGIIM 340
Cdd:COG0534 235 GLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 341 NYVIGGVLISLIYLFSRDILSLFLTSQTTIEIAHSLVMITLWSYLIFGHAQIISATMRASGTVLWPTVIGVVSIWLVEVP 420
Cdd:COG0534 315 ALGIGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLP 394
|
410 420 430
....*....|....*....|....*....|....
gi 446726807 421 VAYYLSyHTSLGIEGIWIGYPAAFIVSLILQYAY 454
Cdd:COG0534 395 LAYLLA-FLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
23-461 |
3.11e-94 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 291.79 E-value: 3.11e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 23 PIWKSMSMFLVPLLLSNVLQSVGQLFGMVVVGRwLGVNDLAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGAKNEDRL 102
Cdd:cd13142 8 SILRTLLKLAWPIIVSNLLQVAYNLADTFWLGR-LGADAVAAPSISWPLIFLFISLGGGLTVAGTALVAQYTGAGDYDKA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 103 KAIVGTTLTFTFIIGVVLAIIGSIFAMDIM-RLMGTPENIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFYF 181
Cdd:cd13142 87 NKVAGQTFSFVIILSLILAVLGYILSRPLLlLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTKTPMKI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 182 LIVSTALNMILLPILIFGWLGAPKLDVYGAAYASVISTVITFIVMLLYLKKKNHPLQLDgtvRKYLRMDGELLKLLLRLG 261
Cdd:cd13142 167 MFGSVLLNVILDPLLIFGIGPFPGLGVAGAALATVISRGIAAVIGLYLLFKGRVGLKIS---LRDLKPDWEWLKKIFRIG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 262 IPASINMILVSLSEIAVIAFVNRYGSDATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGIIMN 341
Cdd:cd13142 244 LPSSIEQSARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALLI 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 342 YVIGGVLISLIYLFSRDILSLFLTSQTTIEIAHSLVMITLWSYLIFGHAQIISATMRASGTVLWPTVIGVVSIWLVEVPV 421
Cdd:cd13142 324 FLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIRIPL 403
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 446726807 422 AYYLSYHTSLGIEGIWIGYPAAFIVSLILQYAYYKL-SWQK 461
Cdd:cd13142 404 AYLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKRgTWKK 444
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
33-456 |
2.33e-86 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 271.31 E-value: 2.33e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 33 VPLLLSNVLQSVGQLFGMVVVGRwLGVNDLAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGAKNEDRLKAIVGTTLTF 112
Cdd:cd13137 8 WPVILENLLQTLVGLVDVFMVGR-LGAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRALGQSLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 113 TFIIGVVLAIIGSIFAMDIMRLMGTPENIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFYFLIVSTALNMIL 192
Cdd:cd13137 87 ALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVNVLNIVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 193 LPILIFGWLGAPKLDVYGAAYASVISTVITFIVMLLYLKKKNHPLQLdgtVRKYLRMDGELLKLLLRLGIPASINMILVS 272
Cdd:cd13137 167 DYVLIFGLWGFPGLGVAGAALATVISRVVGALLLLFLLLRGRLPIKI---SFKGFRLDRKIIKKLLRIGLPAGLEQLLRS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 273 LSEIAVIAFVNRYGSDATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGIIMNYVIGGVLISLI 352
Cdd:cd13137 244 LGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMGLLGLLL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 353 YLFSRDILSLFLTSQTTIEIAHSLVMITLWSYLIFGHAQIISATMRASGTVLWPTVIGVVSIWLVEVPVAYYLSYHTSLG 432
Cdd:cd13137 324 FIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYLLGFVLGLG 403
|
410 420
....*....|....*....|....
gi 446726807 433 IEGIWIGYPAAFIVSLILQYAYYK 456
Cdd:cd13137 404 LTGIWLAMFVDTIVRAILLLYRFR 427
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
34-381 |
1.74e-74 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 237.53 E-value: 1.74e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 34 PLLLSNVLQSVGQLFGMVVVGRWLGVnDLAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGAKNEDRLKAIVGTTLTFT 113
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPV-DLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 114 FIIGVVLAIIGSIFAMDIMRLMGTPENIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFYFLIVSTALNMILL 193
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 194 PILIFGWLGApkLDVYGAAYASVISTVITFIVMLLYLKKKNhplQLDGTVRKYLRMDGELLKLLLRLGIPASINMILVSL 273
Cdd:TIGR00797 160 YILIFGKFGF--LGIVGAALATVISYWLMFLLLLYYIKKAK---KIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 274 SEIAVIAFVNRYGSDATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGIIMNYVIGGVLISLIY 353
Cdd:TIGR00797 235 SFALLALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILI 314
|
330 340
....*....|....*....|....*...
gi 446726807 354 LFSRDILSLFLTSQTTIEIAHSLVMITL 381
Cdd:TIGR00797 315 LFREFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
33-456 |
5.41e-69 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 225.67 E-value: 5.41e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 33 VPLLLSNVLQSVGQLFGMVVVGRWLGvNDLAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGAKNEDRLKAIVGTTLTF 112
Cdd:cd12082 2 APLLLSMLLQTLYNLVDTFFLGRLLG-DALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 113 TFIIGVVLAIIGSIFAMDIMRLMGTPENIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFYFLIVSTALNMIL 192
Cdd:cd12082 81 AILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 193 LPILIFGWLGaPKLDVYGAAYASVISTVITFIVMLLYLKKKNHPLqldGTVRKYLRMDGELLKLLLRLGIPASINMILVS 272
Cdd:cd12082 161 DPLLIFGLGP-PELGIAGAALATVISYVIGALLLLIYLRKGKKIL---KFKLSLLKPDLELLRRLLRIGLPSAIQNSLLS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 273 LSEIAVIAFVNRY-GSDATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGIIMNYVIGGVLISL 351
Cdd:cd12082 237 LGLLIIVAIVAAFgGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 352 IYLFSRDILSLFLTSQTTIEIAHSLVMITLWSYLIFGHAQIISATMRASGTVLWPTVIGVVSIWLVEVPVAyYLSYHTSL 431
Cdd:cd12082 317 ILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLA-YVLAYLGL 395
|
410 420
....*....|....*....|....*
gi 446726807 432 GIEGIWIGYPAAFIVSLILQYAYYK 456
Cdd:cd12082 396 GLYGIWLALVISLILAALVLLLFFR 420
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
33-464 |
4.22e-67 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 221.22 E-value: 4.22e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 33 VPLLLSNVLQSVGQLFGMVVVGRwLGVNDLAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGAKNEDRLKAIVGTTLTF 112
Cdd:cd13134 10 WPIFIELLLQMLLGTIDTFMLSR-YSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIAGVALLF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 113 TFIIGVVLAIIGSIFAMDIMRLMGTPENIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFYFLIVSTALNMIL 192
Cdd:cd13134 89 NLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNILNIVG 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 193 LPILIFGWLGAPKLDVYGAAYASVISTVITFIVMLLYLKKKNHPLQldgTVRKYLRMDGELLKLLLRLGIPASINMILVS 272
Cdd:cd13134 169 NYLLIFGWFGLPKLGVAGVAISTVISRAVGLVLLFILLFRKLKIRF---RLKDLRPFPKKLLKKILKIGLPSAGEELSYN 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 273 LSEIAVIAFVNRYGSDATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGIIMNYVIGGVLISLI 352
Cdd:cd13134 246 LSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLVSLAVALLL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 353 YLFSRDILSLFLTSQTTIEIAHSLVMITLwsYLIFGHA---QIISAtMRASGTVLWPTVIGVVSIWLVEVPVAYYLSYHT 429
Cdd:cd13134 326 ALFREPILGLFTDDPEIIALGKTLLLISI--LLEPGRAfniVLIGS-LRAAGDARFPVLIGIISMWGISVPLAYLLGIVL 402
|
410 420 430
....*....|....*....|....*....|....*.
gi 446726807 430 SLGIEGIWIGYPA-AFIVSLILQYAYYKLSWQKKRI 464
Cdd:cd13134 403 GLGLLGVWIAFAAdEWVRGIIMLWRWRSGKWIKKAL 438
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
23-456 |
3.61e-59 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 200.04 E-value: 3.61e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 23 PIWKSMSMFLVPLLLSNVLQSVGQLFGMVVVGRWLGVNDLAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGAKNEDRL 102
Cdd:cd13143 1 PIGKLFLKFALPAIIGMLVNGLYNIVDGIFVGHGVGALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 103 KAIVGTTLTFTFIIGVVLAIIGSIFAMDIMRLMGTPENIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFYFL 182
Cdd:cd13143 81 NRIFSTALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 183 IVSTALNMILLPILIFGWlgapKLDVYGAAYASVISTVITFIVMLLYLKKKNHPLQLdgtVRKYLRMDGELLKLLLRLGI 262
Cdd:cd13143 161 LIGAVLNIILDPLFIFVL----GLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKL---SLLRFKLSLKIIKEILALGF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 263 PASINMILVSLSEIAVIAFVNRYGSDAT-AAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGIIMN 341
Cdd:cd13143 234 PSFLMQLSSSVVTIVLNLTLLGYGGDIGvAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVA 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 342 YVIGGVLISLIYLFSRDILSLFLTSQTTIEIAHSLVMITLWSYLIFGHAQIISATMRASGTVLWPTVIGVVSIWLVEVPV 421
Cdd:cd13143 314 LIYGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIPL 393
|
410 420 430
....*....|....*....|....*....|....*
gi 446726807 422 AYYLSYHtsLGIEGIWIGYPAAFIVSLILQYAYYK 456
Cdd:cd13143 394 LLILPRL--FGLDGIWLAFPLAEILTLLLALILLK 426
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
23-463 |
1.23e-55 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 191.29 E-value: 1.23e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 23 PIWKSMSMFLVPLLLSNVLQSVGQLFGMVVVGRwLGVNDLAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGAKNEDRL 102
Cdd:cd13139 11 SLNRAIFLLAIPMVLEMVMESLFAVVDLYFVSR-LGALAIATVGLTESVLTIVYSIAIGLSMAATALVARRIGEKDPEGA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 103 KAIVGTTLTFTFIIGVVLAIIGSIFAMDIMRLMGTPENIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFYFL 182
Cdd:cd13139 90 GFAAVQAILLGVALSLILSILGYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDAAIAMRSL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 183 IVSTALNMILLPILIFGWLGAPKLDVYGAAYASVISTVITFIVMLLYLKKKNHPLQLdgtVRKYLRMDGELLKLLLRLGI 262
Cdd:cd13139 170 WLANGLNIILDPLFIFGLGPIPAMGVTGAAIATTIGRSIGVLYQLYHLFKGKGRIQI---RRRHLKLDWAIIKKIIKIAV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 263 PASINMILVSLSEIAVIAFVNRYGSDATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGIIMNY 342
Cdd:cd13139 247 GGILQFLIASSSWIFLVRIIAEFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVWRAGKYNM 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 343 VIGGVLISLIYLFSRDILSLFLTSQTTIEIAHSLVMITLWSYLIFGHAQIISATMRASGTVLWPTVIGVVSIWLVEVPVA 422
Cdd:cd13139 327 VFLGIVSLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFWLFQIPLA 406
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 446726807 423 YYLSYHTSLGIEGIWIGYPAAFIVSLILQYAYYKLSWQKKR 463
Cdd:cd13139 407 YLLARHLNLGPKGVFIAIPIAETVLAIAAIILFRRGKWKTV 447
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
25-466 |
2.62e-55 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 190.40 E-value: 2.62e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 25 WKSMSMFLVPLLLSNVLQSVGQLFGMVVVGRwLGVNDLAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGAKNEDRLKA 104
Cdd:cd13131 2 LRALLRLALPILIAQLAQMAMGFVDTVMAGR-LGADDLAAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 105 IVGTTLTFTFIIGVVLAIIGsIFAMDIMRLMGTPENIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFYFLIV 184
Cdd:cd13131 81 AVRQGLWLALLLSLPLMLLL-WLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 185 STALNMILLPILIFGWLGAPKLDVYGAAYASVISTVITFIVMLLYLkKKNHPLQLDGTVRKYLRMDGELLKLLLRLGIPA 264
Cdd:cd13131 160 ALVLNIPLNYVLIFGKFGLPALGGAGAGLATAIVYWLMFLALAFYI-RRHKRFRRYRLFARFWRPDWARLKELLRLGLPI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 265 SINMilvsLSEIAVIAFVN----RYGSDATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGIIM 340
Cdd:cd13131 239 GLTI----FFEVSLFAAVAllmgRLGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 341 NYVIGGVLISLIYLFSRDILSLFLTSQTTIEIAHSLVMITLWSYLIFGHAQIISATMRASGTVLWPTVIGVVSIWLVEVP 420
Cdd:cd13131 315 GVGFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGIGLP 394
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 446726807 421 VAYYLSYHTSLGIEGIWIGYPAAFIVSLILqyayykLSWQKKRITR 466
Cdd:cd13131 395 LGYLLAFTTGLGAFGVWIGLIIGLALAAIL------LLWRFRRLQR 434
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
33-456 |
9.77e-54 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 186.19 E-value: 9.77e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 33 VPLLLSNVLQSVGQLFGMVVVGrWLGVNDLAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGAKNEDRLKAIVGTTLTF 112
Cdd:cd13133 12 LPLVLSMLSQTVMGFTDRAFLG-RLSEVALAASGPAGVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRVLWQGLYF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 113 TFIIGVVLAIIGSIFAMDIMRLMGTPENIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFYFLIVSTALNMIL 192
Cdd:cd13133 91 SLLLAPLLALLSALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVMVVVNIVL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 193 LPILIFGWLGAPKLDVYGAAYASVISTVITFIVMLLYLKKKNHPLQLdgTVRKYLRMDGELLKLLLRLGIPASINMILVS 272
Cdd:cd13133 171 DYALIFGKLGFPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRRF--GLRRAWRFDRELLRRILRLGLPSGLQFFLDV 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 273 LSEIAVIAFVNRYGSDATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGIIMNYVIGGVLISLI 352
Cdd:cd13133 249 GAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAYMLLLGILF 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 353 YLFSRDILSLFLTSQTTIEI---AHSLVMITLWSYLIFGHAQIISATMRASGTVLWPTVIGVVSIWLVEVPVAYYLSYHt 429
Cdd:cd13133 329 LLFPELLLSIFTPGADFALIaelAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLYLLPPAYLLVVL- 407
|
410 420
....*....|....*....|....*..
gi 446726807 430 SLGIEGIWIGYPAAFIVSLILQYAYYK 456
Cdd:cd13133 408 GAGLAGAWTVETVYVIVLALIFLLRFR 434
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
23-437 |
2.46e-53 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 185.04 E-value: 2.46e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 23 PIWKSMSMFLVPLLLSNVLQSVGQLFGMVVVGRwLGVNDLAAI--SAFFPLFFLLVSFVIGIGSGssILIGQAFGAKNED 100
Cdd:cd13140 2 PILKTLLRLALPIMGTSFIQMAYNLTDMFWVGR-LGSDAVAAVgtAGFFVWLAYALALLSKIGAQ--VKVSQSIGAKDEK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 101 RLKAIVGTTLTFTFIIGVVLAIIGSIFAMDIMRLMG-TPENIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPF 179
Cdd:cd13140 79 EARKYARNALQLNLLLGILYGLLLLLFAKPLIGFFNlGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 180 YFLIVSTALNMILLPILIFGWLGAPKLDVYGAAYASVISTVITFIVMLLYLKKKNHplqLDGTVRKYLRMDGELLKLLLR 259
Cdd:cd13140 159 IINAIGLVLNIILDPLLIFGFGPFPALGVAGAALATVLAQAIVFLLFLYALKKKKG---LFLKIRILKRPDRKYIKEILK 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 260 LGIPASINMILVSLSEIAVIAFVNRYGSDATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGII 339
Cdd:cd13140 236 LGLPVALQSILFALISMILARIIASFGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALK 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 340 MNYVIGGVLISLIYLFSRDILSLFLTSQTTIEIAHSLVMITLWSyLIFGHAQIISATM-RASGTVLWPTVIGVVsIWLVE 418
Cdd:cd13140 316 IASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFS-QLFMCLEITTTGAfNGLGRTKPPAIISIV-FNGLR 393
|
410
....*....|....*....
gi 446726807 419 VPVAYYLSyHTSLGIEGIW 437
Cdd:cd13140 394 IPLALLLS-PTGLGLNGIW 411
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
56-454 |
6.68e-53 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 183.95 E-value: 6.68e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 56 WLGVNDLAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGAKNEDRLKAIVGTTLTFTFIIGVVLAIIGSIFAMDIMRLM 135
Cdd:cd13145 38 KISTEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKARRYAAQGLSFGIILAILLTVIGLFAAPPLFRLL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 136 GTPENIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFYFLIVSTALNMILLPILIFGWLGAPKLDVYGAAYAS 215
Cdd:cd13145 118 GAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKSYRNFLIIGFFLNIILDPLFIFGGGGIPAMGVSGIALAT 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 216 VIStviTFIVMLLYLKKKNHPLQLDGTVRKYLRMDGELLKLLLRLGIPASINMILVSLSEIAVIAFVNRYGSDATAAYGV 295
Cdd:cd13145 198 IIS---QFIGMFYLLYKVRKSGIISGCRLRDFIPRLDVYKEILKQGFPASLNMMTIGLGIFVITYFVGQFGDEAVAAYGI 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 296 VNQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGIIMNYVIGGVLISLIYLFSRDILSLFLTSQTTIEIAHS 375
Cdd:cd13145 275 ALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRETYKKALKYGFVIMVVATVFLLFFAEPLMSLFTNDPAVIAIGAG 354
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446726807 376 LVMITLWSYLIFGHAQIISATMRASGTVLWPTVIGVVSIWLVEVPVAYYLSYHTSLGIEGIWIGYPAAFIVSLILQYAY 454
Cdd:cd13145 355 YLRIDALIFYAYVVLFISVSVLQGLKRPIFALWIGLYRQLVGPALVFWLLVNVLGLGVTGIWWGIFTIVWSAAIIALLY 433
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
21-456 |
3.13e-51 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 179.35 E-value: 3.13e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 21 SKPIWKSMSMFLVPLLLSNVLQSVGQLFGMVVVGrWLGVNDLAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGAKNED 100
Cdd:cd13144 3 SGPVLRLLLTMSIPAMISMLFQALYNIVDSIFVA-RLGENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 101 RLKAIVGTTLTFTFIIGVVLAIIGSIFAMDIMRLMGTPENIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFY 180
Cdd:cd13144 82 EANKAANNGLLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 181 FLIVSTALNMILLPILIFGWLGAPKLDVYGAAYASVISTVITFIVMLLYLKKKNHPLQLDGTVRkylRMDGELLKLLLRL 260
Cdd:cd13144 162 AQLIGAIINIILDPILIFGLFGFPAMGIAGAAIATVIGQILAMFLAFFFLLRKNKDVQPDLRLF---RPSLRIIKEIYAV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 261 GIPASINMILVSLSEIAVIAFVNRYGSDATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGIIM 340
Cdd:cd13144 239 GLPSIIMQAISSVMVFGLNKILAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAILI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 341 NYVIGGVLISLIYLFSRDILSLFLTSQTTIEIAHSLVMITLWSYLIFGHAQIISATMRASGTVLWPTVIGVVSIWLVEVP 420
Cdd:cd13144 319 AVVIMLAGGLLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVLLP 398
|
410 420 430
....*....|....*....|....*....|....*.
gi 446726807 421 VAYYLSYhtSLGIEGIWIGYPAAFIVSLILQYAYYK 456
Cdd:cd13144 399 LAWLLAK--MFGLNGVWWSFPIAEIVSFLLSLLFLK 432
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
33-457 |
8.05e-47 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 167.72 E-value: 8.05e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 33 VPLLLSNVLQSVGQLFGMVVVGRwLGVNDLAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGAKNEDRLKAIVGTTLTF 112
Cdd:cd13147 16 IPMIIAMLLQTLYNLVDAIWVAG-LGADALAAIGFVFPLFMIIIGLGNGLGAGASSAISRRIGAKDKEGADNAAVHSILL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 113 TFIIGVVLAIIGSIFAMDIMRLMGTpENIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFYFLIVSTALNMIL 192
Cdd:cd13147 95 GLIISIILTIVLLPFLEPILVLMGA-GEVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMVAGSILNIIL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 193 LPILIFgWLGapkLDVYGAAYASVISTVITFIVML--LYLKKKNHPLqldgTVRKYLRMDGELLKLLLRLGIPASINMIL 270
Cdd:cd13147 174 DPIFIY-TLG---LGIAGAAWATVISMLISSLVLLywFFVKKDTYVS----LSLKNFKFDKKIVKDILKVGIPASLEQLI 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 271 VSLSEIAVIAFVNRY-GSDATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGIIMNYVIGGVLI 349
Cdd:cd13147 246 MSVLMIILNLILVIVaGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTAYNYSIKLGLIIELIIA 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 350 SLIYLFSRDILSLFLTSQTTIEIAHSLV--MITLWSYLIFGHAQIISATM-RASGTVLWPTVIGVVSIWLVEVPVAYYLS 426
Cdd:cd13147 326 ILIFIFAPQIAYLFTYSEESAHLAPEIVafLRIMCLFLPFVPFGMMSSSMfQGIGKGLTSLIITILRELIFQVLFAYLFA 405
|
410 420 430
....*....|....*....|....*....|.
gi 446726807 427 YHTSLGIEGIWIGYPAAFIVSLILQYAYYKL 457
Cdd:cd13147 406 IVLGLGLFGVWWGIVLGNAIGSIVGYLWARL 436
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
57-456 |
3.59e-46 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 165.94 E-value: 3.59e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 57 LGVNDLAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGAKNEDRLKAIVGTTLTFTFIIGVVLAIIGSIFAMDIMRLMG 136
Cdd:cd13149 39 LGTKELAAISFTFPVVLFLNSLTIGLGIGASAVISRAIGAGDRNKAKRLATDSLILSLLLSVIVSLLGLFTIPPLFSLLG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 137 TPENIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFYFLIVSTALNMILLPILIFGWLGAPKLDVYGAAYASV 216
Cdd:cd13149 119 ASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKRPSLVMLGAALVNVILDPILIFGFGPIPGMGIAGAAIATV 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 217 ISTVITFIVMLLYLKKKNHplqLDGTVRKYLRMDGELLKLLLRLGIPASINMILVSLSEIAVIAFVNRYGSDATAAYGVV 296
Cdd:cd13149 199 ISRALGLGAALYFLHYHHR---LIDFSEPSLKALFRSWKDILSIGIPAALSNILTPLSAAFITALVATYGPAAVAAFGVA 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 297 NQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGIIMNYVIGGVLISLIYLFSRDILSLFLTSQTTIEIAHSL 376
Cdd:cd13149 276 TRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISLKFSLIYGAILGIVLALFAGWLASLFSAEPEVIELITLY 355
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 377 VMITLWSYLIFGHAQIISATMRASGTVLWPTVIGVVSIWLVEVPVAYYLSYHtsLGIEGIWIGYPAAFIVSLILQYAYYK 456
Cdd:cd13149 356 LLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRVFLLYIPLAYVGSHL--LGFAGVFIGALAGNLIAGILAYFIAK 433
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
33-452 |
3.93e-39 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 146.69 E-value: 3.93e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 33 VPLLLSNVLQSVGQLFGMVVVGRwLGVNDLAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGAKNEDRLKAIVGTTLTF 112
Cdd:cd13141 18 LPIAIGMIIQTLYFLVDLYFVGQ-LGDAALAGVSLAGNVMFFVMALTQVLNVGTAALVSHAVGRKDQGEANAVFNQSLLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 113 TFIIGVVLAIIGSIFAMDIMRLMGTPENIIEISVHYariLFISMPVLFLYFAYTTF---MRGTGDSKTPFYFLIVSTALN 189
Cdd:cd13141 97 AAVLGLVVLVLGYLFGRLYLETLAADAATVEAATTY---LYWFIPSLALQFILTVLgaaLRGTGIVKPFMVIQILAVLLN 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 190 MILLPILIFGWLGAPKLDVYGAAYASVISTVITFIVMLLYLKKKNHPLQLDgtvRKYLRMDGELLKLLLRLGIPASINMI 269
Cdd:cd13141 174 IILAPILITGWGTGRALGVAGAGLASSISVAIAVVLLLYYFLRLEKYLRLD---LALWRPDLPTWKRLLKIGLPSGGEFL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 270 LVSLSEIAVIAFVNRYGSDATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGIIMNYVIGGVLI 349
Cdd:cd13141 251 LTFVYMAVIYWALRPFGAAAQAGFGIGSRIMQSLFLPAMAIAFAAPAIAGQNFGAGNYDRVRETFRITAILTTALMLVLT 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 350 SLIYLFSRDILSLFLTSQTTIEIAHSLVMITLWSYLIFGHAQIISATMRASGTVlWPTVIGVVSIWLVEVPVAYYLSYHT 429
Cdd:cd13141 331 LLCQLVPELLVTPFSDDAAVIAVAATFLRYVSWNFVAAGLVFTCSGMFQALGNT-WPSLLSSASRLLTFALPVIWLSAQP 409
|
410 420
....*....|....*....|...
gi 446726807 430 SLGIEGIWIGYPAAFIVSLILQY 452
Cdd:cd13141 410 DFRIEQIWYLSVATTILQAALSL 432
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
23-446 |
8.87e-38 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 143.18 E-value: 8.87e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 23 PIWKSMSMFLVPLLLSNVLQSVGQLFGMVVVGRwLGVNDLAAISAFFPLFFLLVSFVIG-IGSGSSILIGQAFGAKNEDR 101
Cdd:cd13148 9 PILPTLLRLALPNILALLVQTLVGLAETYFVGQ-LGTDALAGVALVFPLLMLTQMMSNGaMGGGVSSAIARALGAGDRER 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 102 LKAIVGTTLTFTFIIGVVLAIIGSIFAMDIMRLMGTPENIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFYF 181
Cdd:cd13148 88 AEALVWHALVIALAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGTGNMRVPALV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 182 LIVSTALNMILLPILIFGWLGAPKLDVYGAAYASVISTVITFIVMLLYLKKKNHPLQLDgtvRKYLRMDGELLKLLLRLG 261
Cdd:cd13148 168 TLVGAVVQIPLSPGLILGWGPLPRLGVAGAAVAAVLYYALAALVLLRYLASGRSRLRLR---LRALRLERRLFRDILRVG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 262 IPASINMILVSLSEIAVIAFVNRYGSDATAAYGVVNQVaSYVQMPAV-SLGITVSIFAAQSIGANQFDRLQKVVKAGIIM 340
Cdd:cd13148 245 LLAALSPLQTNLTVLLLTGLVGRFGTAALAGYGIGSRL-EFLLIPLVfGLGAAMTAMVGMNIGAGQIARARRIAWTGALM 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 341 NYVIGGVLISLIYLFSRDILSLFLTSQTTIEIAHSLVMITLWSYLIFGHAQIISATMRASGTVLWPTVIGVVSIwLVEVP 420
Cdd:cd13148 324 AAVLAGAIGLVLALFPELWLGLFTHDPAVLAAGASYLRIVGPFYGFFGLGLALYFASQGAGRMLWPVLAGTLRL-LIAAG 402
|
410 420
....*....|....*....|....*.
gi 446726807 421 VAYYLSYHTSLGIEGIWIGYPAAFIV 446
Cdd:cd13148 403 GGWIAVALFGAGLAGLFAAAAAAMVA 428
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
26-462 |
8.52e-35 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 134.62 E-value: 8.52e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 26 KSMSMFLVPLLLSNVLQSVGQLFGMVVVGRwLGVNDLAAISAFFPLFFLL-VSFVIGIGSGSSILIGQAFGAKNEDRLKA 104
Cdd:cd13132 3 KKLLRLAAPLVLTSLLQYSLSVVSVVFVGH-LGKLELAAASLASSFANVTgFSILLGLASALDTLCGQAFGAKNYKLVGV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 105 IVGTTLTFTFIIGVVLAIIGsIFAMDIMRLMGTPENIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFYFLIV 184
Cdd:cd13132 82 YLQRALVILLLCCVPISLLW-LNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 185 STALNMILLPILIFGwlgaPKLDVYGAAYASVISTVITFIVMLLY-LKKKNHPLQLDGTVRKYLRMDGELLKLllrlGIP 263
Cdd:cd13132 161 ALLLNILLNYLLVFV----LGLGFIGAALATSISYWLIVVLLLLYiFFSKGHKATWGGFSREAFRGWGPFLKL----AIP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 264 ASINMIL-VSLSEIAVIAFVNRYGSDATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGIIMNY 342
Cdd:cd13132 233 SALMLCLeWWAFEILVLLAGLLPGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 343 VIGGVLISLIYLFSRDILSLFLTSQTTIEIAHSLVMITLWSYLIFGHAQIISATMRASGTVLWPTVIGVVSIWLVEVPVA 422
Cdd:cd13132 313 VIGVVVAILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVG 392
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 446726807 423 YYLSYHTSLGIEGIWIGYPAA-FIVSLILQYAYYKLSWQKK 462
Cdd:cd13132 393 LLLAFVLGLGLKGLWIGLIAGlILQAVILLLIILRTDWDKE 433
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
33-456 |
1.07e-33 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 131.65 E-value: 1.07e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 33 VPLLLSNVLQSVGQLFGMVVVGRwLGVNDLAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGAKNEDRLKAIVGTTLTF 112
Cdd:cd13135 8 IPLILQNLVSQLQMLVDRAFLGR-ISIRYYSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDYAISSIVY 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 113 TFIIGVVLAIIGSIFAMDIMRLMGTPENIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFYFLIVSTALNMIL 192
Cdd:cd13135 87 NSIIGVILFLLWLFGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIKNLLNVIL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 193 LPILIFGWLGAPKLDVYGAAYASVISTVITFIVMLLYL---KKKNHPLQLDGTVRKYLRmdgeLLKLLLRLGIPASINMI 269
Cdd:cd13135 167 DYVLIFGNFGFPRLGIIGAAIATTIANVLNLIILVYLCrkiKKLTFKLSNTKVLKANIR----PYKFTIKLGLPLGGEEF 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 270 LVSLSEIAVIAFVNRYGSDATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGIIMNYVIGGVLI 349
Cdd:cd13135 243 LWNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLIYIAAA 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 350 SLIYLFSRDILSLFlTSQTTIeIAHSLVMITLWSYLIFGHA--QIISATMRASGTVLWpTVIGVVSIWLVEVPVAYYLSY 427
Cdd:cd13135 323 IVFLAFPYKILSLF-TNDPEL-INYSIPYLIFIIIILFFKSinIVYGFAIRAIGDTKW-MLYTQIIGTIIVVSVALLLIF 399
|
410 420
....*....|....*....|....*....
gi 446726807 428 HTSLGIEGIWIGYPAAFIVSLILQYAYYK 456
Cdd:cd13135 400 VFKLGLAGVYITLFIDEIIRAIINFLKYR 428
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
34-195 |
4.82e-30 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 114.58 E-value: 4.82e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 34 PLLLSNVLQSVGQLFGMVVVGRwLGVNDLAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGAKNEDRLKAIVGTTLTFT 113
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGH-LGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 114 FIIGVVLAIIGSIFAMDIMRLMGTPENIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFYFLIVSTALNMILL 193
Cdd:pfam01554 80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 446726807 194 PI 195
Cdd:pfam01554 160 YL 161
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
25-448 |
6.10e-30 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 121.46 E-value: 6.10e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 25 WKSMSMFLVPLLLSNVLQSVGQLFGMVVVGRwLGVNDLAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGAKNEDRLKA 104
Cdd:PRK01766 11 ARQLLALALPILLAQVAQTAMGFVDTVMAGG-VSATDLAAVAIGTSIWLPVILFGHGLLLALTPIVAQLNGAGRRERIAH 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 105 IVGTTLTFTFIIGVVLAIIGSIFAMDIMRLMGTPENIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFYFLIV 184
Cdd:PRK01766 90 QVRQGLWLALFLSVLIMLVLYNAVPPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGKTKPTMVIGFL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 185 STALNMILLPILIFGWLGAPKLDVYGAAYASVISTVITFIVMLLYLKKkNHPLQLDGTVRKYLRMDGELLKLLLRLGIPA 264
Cdd:PRK01766 170 GLLINIPLNYIFIYGKFGFPELGGVGCGVATAIVYWVMFLAMLIYIKR-ARRFRDFRLFKGLYKPDWAVIKRLLKLGLPI 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 265 SINMIL-VSLSeIAVIAFVNRYGSDATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGIIMNYV 343
Cdd:PRK01766 249 GLAIFFeVSLF-AVVTLLVSPLGTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYIGLAVGLG 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 344 IGGVLISLIYLFSRDILSLFLTSQTTIEIAHSLVMITLWSYLIFGHAQIISATMRASGTVLWPTVIGVVSIWLVEVPVAY 423
Cdd:PRK01766 328 MALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIFFITFIAYWVLGLPLGY 407
|
410 420
....*....|....*....|....*
gi 446726807 424 YLSYHTSLGIEGIWIGypaaFIVSL 448
Cdd:PRK01766 408 ILALTDPMGPFGFWIG----LIIGL 428
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
30-456 |
1.25e-27 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 114.20 E-value: 1.25e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 30 MFLVPLLLSNVLQSvgqLFGMV---VVGRWLGVNDLAAI---SAFFPLFFLLVSFVIgigSGSSILIGQAFGAKNEDRLK 103
Cdd:cd13136 7 ALALPAILSNITVP---LLGLVdtaVVGHLGSAAYLGAValgTTIFNTLFWLFGFLR---MGTTGLVAQALGAGDREEAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 104 AIVGTTLTFTFIIGVVLAIIGSIFAMDIMRLMGTPENIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFYFLI 183
Cdd:cd13136 81 ALLVRALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 184 VSTALNMILLPILIFGWlgapKLDVYGAAYASVISTVITFIVMLLYLKKKnhpLQLDGTVRKYLRMDGELLKLLLRLGIP 263
Cdd:cd13136 161 VGNVVNIVLDPLFVFGL----GWGVAGAALATVIAQYLGALLGLWLLRRR---VRLLGKSLSRRLPSKAALKRLFKLNRD 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 264 ASINMILVSLSEIAVIAFVNRYGSDATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGIIMNYV 343
Cdd:cd13136 234 IFIRTLALLAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 344 IgGVLISLIYLFSRDILSLFLTSQTtiEIAHSLVMITLWSYLIfghaQIISAT----------MRASGTVLWPTVIGVVS 413
Cdd:cd13136 314 L-GVLLALLFFLGGEPIIRLFTDDP--AVLALAATYLPWLALL----PPIGALafvldgifigATDTRYLRNSMLVSLAV 386
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 446726807 414 IwlveVPVAYYLsyHTSLGIEGIWIGYPAAFIVSLILQYAYYK 456
Cdd:cd13136 387 F----LPLLFLL--VPLWGNHGLWLALILFMLLRGLTLALRLP 423
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
62-452 |
1.94e-26 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 110.95 E-value: 1.94e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 62 LAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGAKNEDRLKAIVGTTLTFTFIIGVVLAIIGSIFAMDIMRLMGTPENI 141
Cdd:cd13146 46 VGGIGLVFPLGMIFLALGNGIQVGVSSLLARAIGAQRAKELDQAADSGLALALLAATVIVVLGYIFAEPLLQLLGAKGLL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 142 IEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFYFLIVSTALNMILLPILIFGWlgapKLDVYGAAYASVISTVI 221
Cdd:cd13146 126 LEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLIGTVVNIVLDPILIFVF----DMGVKGAALATVLAQAI 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 222 TFIVMLLYLKKKNHPLQLDGTVRKylrMDGELLKLLLRLGIPASINMILVSLSEIAVIAFVNRYGSDATAAYGVVNQVAS 301
Cdd:cd13146 202 SLLYLLYVFLIGKSNVTIHIKLSN---ISSSVIVEILRVGLPQMLLQLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQ 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 302 YVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGIIMNYVIGGVLISLIYLFSRDILSLFLTSQTTIEIAHSLVMITL 381
Cdd:cd13146 279 FILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVVVLVLVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMA 358
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446726807 382 WSYLIFGHAQIISATMRASGTVLWPTVIGVVSIWLVEVPVAYYLSYHTSLGIEGIWIGYPAAFIVSLILQY 452
Cdd:cd13146 359 LALPFVAISILVTEFFQAIGKAWPSLLLTLIRHVFLSVPVVYLLAYVFGKGITGVYFGIVSANFFTALLAM 429
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
263-423 |
2.17e-24 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 98.79 E-value: 2.17e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 263 PASINMILVSLSEIAVIAFVNRYGSDATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGIIMNY 342
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 343 VIGGVLISLIYLFSRDILSLFLTSQTTIEIAHSLVMITLWSYLIFGHAQIISATMRASGTVLWPTVIGVVSIwLVEVPVA 422
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISL-LLNIPLN 159
|
.
gi 446726807 423 Y 423
Cdd:pfam01554 160 Y 160
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
33-234 |
8.79e-19 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 88.34 E-value: 8.79e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 33 VPLLLSNVLQSVGQLFGMVVVGRwLGVNDLAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGAKNEDRLKAIVGTTLTF 112
Cdd:cd13137 233 LPAGLEQLLRSLGFLVLLAIVAS-YGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRL 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 113 TFIIGVVLAIIGSIFAMDIMRLMGTPENIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFYFLIVSTALNMIL 192
Cdd:cd13137 312 GVLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLP 391
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 446726807 193 LpILIFGWLGapKLDVYGAAYASVISTVITFIVMLLYLKKKN 234
Cdd:cd13137 392 L-AYLLGFVL--GLGLTGIWLAMFVDTIVRAILLLYRFRKGK 430
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
21-231 |
3.29e-16 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 80.45 E-value: 3.29e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 21 SKPIWKSMSMFLVPLLLSNVLQSVGQLFGMVVVGRWLGVNDLAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGAKNED 100
Cdd:cd12082 214 DLELLRRLLRIGLPSAIQNSLLSLGLLIIVAIVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFD 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 101 RLKAIVGTTLTFTFIIGVVLAIIGSIFAMDIMRLMGTPENIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFY 180
Cdd:cd12082 294 RARRITWVALLIGLLIGAVLGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLI 373
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 446726807 181 FLIVSTALNMILLpILIFGWLGapkLDVYGAAYASVISTVITFIVMLLYLK 231
Cdd:cd12082 374 VSLLSYWVVRLPL-AYVLAYLG---LGLYGIWLALVISLILAALVLLLFFR 420
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
21-231 |
8.32e-15 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 76.04 E-value: 8.32e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 21 SKPIWKSMSMFLVPLLLSNVLQSVGQLFGMVVVGRWLGVNDLAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFgAKNED 100
Cdd:cd13128 201 DLKLAKELLRFSIPLALSGIFSLIYTRIDTIMLGYFLGDAAVGIYNAAYRIAELLLFIPSAISTALFPRISELY-KNDKD 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 101 RLKAIVGTTLTFTFIIGVVLAIIGSIFAMDIMRLMGTPENIIEISVhyARILFISMPVLFLYFAYTTFMRGTGDSKTPFY 180
Cdd:cd13128 280 ELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEEYLPAALV--LQILAWGFLFIFLNGIFGSILQAIGKQKLTLK 357
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 446726807 181 FLIVSTALNMILLPILIfgwlgaPKLDVYGAAYASVISTVITFIVMLLYLK 231
Cdd:cd13128 358 ILLIGALLNVILNLLLI------PKYGIIGAAIATLISEFIIFILLLYLLK 402
|
|
| PRK10189 |
PRK10189 |
EmmdR/YeeO family multidrug/toxin efflux MATE transporter; |
25-452 |
3.54e-14 |
|
EmmdR/YeeO family multidrug/toxin efflux MATE transporter;
Pssm-ID: 182293 [Multi-domain] Cd Length: 478 Bit Score: 74.39 E-value: 3.54e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 25 WKSMSMFLVPLLLSNVLQSVGQLFGMVVVGrWLGVNDLAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGAKNEDRLKA 104
Cdd:PRK10189 28 WREITPLAVPIFIENLCVLLMGVLSTFLVS-WLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 105 IVGTTLTFTFIIGVVLAIIGSIFAMDIMRLMG---TPEnIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFYF 181
Cdd:PRK10189 107 AARQSLVIMTLFAVLLAVLIHFFGEQIIDLVAgdaTPE-VKALALTYLELTVWSYPAAAITLIGSGALRGAGNTKIPLLI 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 182 LIVSTALNMILLPILIFGWLGAPKLDVYGAAYASVISTVITFIVMLLYLKKKNHPlQLDGTVRKYLR-MDGELLKLLLRL 260
Cdd:PRK10189 186 NGGMNILNIIISSILIYGLFSWQGLGFVGAGLGLTISRYIGAVAIIWVLMIGFNP-ALRISLKSYFKpLNFAIIWEVMGI 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 261 GIPASINMILVSLSEIAVIAFVNRYGSDATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAgIIM 340
Cdd:PRK10189 265 GIPASIESVLFNGGKLLTQMFVAGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGTRLGKGQIAQAERQLRH-VFW 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 341 NYVIGGVLISLIYLFSRDILSLFLT-SQTTIEIAHSLVMITLWSYLIFGHAQIISATMRASGTVLWPTVIGVVSIWLVEV 419
Cdd:PRK10189 344 LSTLGLTAIAWLSAPFAGLLASFYTqDPDVKHVVKILIWLNALFMPIWAASWVLPAGLKGARDARYAMWVSMLGMWGCRV 423
|
410 420 430
....*....|....*....|....*....|...
gi 446726807 420 PVAYYLSYHTSLGIEGIWIGYPAAFIVSLILQY 452
Cdd:PRK10189 424 VAGYILGIMLGFGVVGVWMGMFLDWAVRGVLFY 456
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
131-466 |
3.62e-14 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 74.40 E-value: 3.62e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 131 IMRLMGTPENIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFYFLIVSTALNMILLPILIFGWLGAPKLDVYG 210
Cdd:PRK00187 113 LLLLFGQAPQNVDAAMQFLHLLPFALPGYLSFMALRGFTSALGRAGPVMVISLAGAVANLLLNYALIEGWFGLPKLGLMG 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 211 AAYASVISTVITFIVMLLYLKKknHPLQLDGTVRK-YLRMDGELLKLLLRLGIPASIN-MILVSLSEIAVIAfVNRYGSD 288
Cdd:PRK00187 193 IGLVTALVSNGMALALALYIRR--HPAYAAYPLRKgLSRPSRAALRELWRLGLPIGGTyAVEVGLFTFAALC-MGALGST 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 289 ATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGIIMNYVIGGVLISLIYLFSRDILSLFLTSQT 368
Cdd:PRK00187 270 QLAAHQIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRAGRVGIGFGAVVMLLFAGLFWLLPEAIIGLFLDRND 349
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 369 -----TIEIAHSLVMITLWSYLIFGHAQIISATMRASGTVLWPTVIGVVSIWLVEVPVAYYLSYHTSLGIEGIWIGYPAA 443
Cdd:PRK00187 350 pafaeIVQLAVSLLAVAAWFELFDGTQTIAMGAIRGLKDARTTFLIGLACYWLVGAPLAWLLAFTLGWGAVGVWWGLALG 429
|
330 340
....*....|....*....|...
gi 446726807 444 FIVSLIlqYAYYKLSWQKKRITR 466
Cdd:PRK00187 430 LACAAV--ALTLAFEWKTARLLR 450
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
21-186 |
1.95e-12 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 68.68 E-value: 1.95e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 21 SKPIWKSMSMFLVPLLLSNVLQSVGQLFGMVVVGRwLGVNDLAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGAKNED 100
Cdd:cd13134 223 PKKLLKKILKIGLPSAGEELSYNLSQTVITAFIAR-LGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFD 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 101 RLKAIVGTTLTFTFIIGVVLAIIGSIFAMDIMRLMGTPENIIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFY 180
Cdd:cd13134 302 EAYKRVLKSLKIGLLVSLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVL 381
|
....*.
gi 446726807 181 FLIVST 186
Cdd:cd13134 382 IGIISM 387
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
21-234 |
3.95e-12 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 67.94 E-value: 3.95e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 21 SKPIWKSMSMFLVPLLLSNVLQSVGQLFGMVVVGRwLGVNDLAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGAKNED 100
Cdd:cd13133 226 DRELLRRILRLGLPSGLQFFLDVGAFTVFFLLIGR-LGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPD 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 101 RLKAIVGTTLTFTFIIGVVLAIIGSIFAMDIMRLMGTPEN---IIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKT 177
Cdd:cd13133 305 LAMRVTRRGLKLALAYMLLLGILFLLFPELLLSIFTPGADfalIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRF 384
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 446726807 178 PFYFLIVSTALnMILLPILIFGWLGAPKLDVYGAAYASVIstvITFIVMLLYLKKKN 234
Cdd:cd13133 385 VMLAELIVAWL-YLLPPAYLLVVLGAGLAGAWTVETVYVI---VLALIFLLRFRSGK 437
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
13-468 |
1.20e-11 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 66.56 E-value: 1.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 13 ESHKLESESKPIWKSMSMFLVPLLLSNVLQSVGQLFgmvvVGRWLGVNDLAAISAFFPLFFLLVSF--VIGIGSGSSILI 90
Cdd:PRK09575 3 TIMMNQSIYRTFWRYTIPSIAAMLVNGLYQIVDGIF----IGHYVGAEGLAGINMAWPVIGIILGIglMVGMGTGSLLSI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 91 GQafGAKNEDRLKAIVGTTLTFTFIIGVVLAIIGSIFAMDIMRLMGTPENIIEISVHYARILFISMPVLFLYFAYTTFMR 170
Cdd:PRK09575 79 KR--GEGDLEKAKRILTTGLLLLLLLGPIVSVILFLFADDFLRAQGAEGRTLELALQYIQVLIWGCLFTLGAIALPFLLR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 171 gTGDSKTPFYFLIVSTALNMILLPILIFGWLGapkLDVYGAAYASVISTVITFIVMLLYLKKKNHPLQLDgtvRKYLRMD 250
Cdd:PRK09575 157 -NDESPNLATGLMVIGALINIVLDYLFIGWLD---WGLTGAAIATALAQLVVTVLGLGYFFSSRANIRLT---LKELRFN 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 251 GELLKLLLRLGIPASINMILVSLseiaVIAFVNR----YGSDAT-AAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGAN 325
Cdd:PRK09575 230 WSLAPKIVLLGSSSFFMYLYGSF----VVALHNRlfmeYGSALTvGAYAIVGYLMVLYYLVAEGIAEGMQPPVSYYFGAR 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 326 QFDRLQKVVKAGIIMNYVIGGVLISLIYLFSRDILSLFlTSQTTIEIAHSLVMITLWSYLIFGHAQIISATM-----RAS 400
Cdd:PRK09575 306 QYDNIKKLLKLAMKVTVLAGIAWVLLLNLFPETMIALF-NSGDSELIAETIVGIRLHLFAMFLDGFLVLASAyfmavNQG 384
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446726807 401 GTVLWPTvigvVSIWLVEVPVAYYLSyhTSLGIEGIWIGYP----AAFIVSLILQYAYYKLSWQKKRITRLV 468
Cdd:PRK09575 385 GKALFIS----IGNMLIQLPFLFILP--KWLGVDGVWLAMPlsniALSLVVAPMLWRDVKKLKKPTQVEAAV 450
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
31-227 |
1.89e-11 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 65.36 E-value: 1.89e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 31 FLVPLLLSNVLQSVGQLFGMVVVGRWLGVNDLAAISAFFPLFFLLVSFVIGIGSGSSILIGQAFGAKNEDRLKAIVGTTL 110
Cdd:COG2244 178 YSLPLLLSGLLGLLLTNLDRLLLGALLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYRKAL 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 111 TFTFIIGVVLAIIGSIFAMDIMRLMGTPEniIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTPFYFLIVSTALNM 190
Cdd:COG2244 258 RLLLLLGLPLALGLALLAPPLLSLLFGPE--YAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAVLNL 335
|
170 180 190
....*....|....*....|....*....|....*..
gi 446726807 191 ILLPILIfgwlgaPKLDVYGAAYASVISTVITFIVML 227
Cdd:COG2244 336 VLNLLLI------PRYGLVGAAIATLLSYLVLLLLLL 366
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
21-233 |
2.04e-09 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 59.40 E-value: 2.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 21 SKPIWKSMSMFLVPLLLSNVLQSVGQLFGMVVVGR---WLGVNDLAAISAF-------FPLFFLLVSFVIGIGSGSSILI 90
Cdd:cd13124 219 TKEILKELLSYAIPITLSSLILPLLQLIDSFTVPRrlqAAGLSESEATALYgiltgraQPLVQLPTVIATALSTSLVPAI 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 91 GQAFGAKNEDRLKAIVGTTLTFTFIIGVVLAIIGSIFAMDIMRLMGTPENIIEIsvhyARILFISMPVLFLYFAYTTFMR 170
Cdd:cd13124 299 SEAYAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDSEGGLI----LQILAPSILFLSLQQVTAAILQ 374
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446726807 171 GTGDSKTPFYFLIVSTALNMILLPILIfgwlgaPKLDVYGAAYASVISTVITFIVMLLYLKKK 233
Cdd:cd13124 375 GLGKVKIPVINLLIGLLVKIVLNYVLI------PIFGIYGAAIATVIGFLVAALLNLRALKKL 431
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
16-232 |
4.89e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 58.01 E-value: 4.89e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 16 KLESESKPIWKSMSMFLVPLLLSNVLQSVGqLFGMVVVgrwLGVNDLAAIsAFFPLFFLLVSFVI----GIGSGSSILIG 91
Cdd:cd13144 223 RLFRPSLRIIKEIYAVGLPSIIMQAISSVM-VFGLNKI---LAGFGPTAV-AVFGIYFKLQSFVFmpvfGLNNGLIPIVA 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 92 QAFGAKNEDRLKAIVGTTLTFTFIIGVVLAIIGSIFAMDIMRLMGTPENIIEISVHYARILFISMPVLFLYFAYTTFMRG 171
Cdd:cd13144 298 YNYGAGNKDRIREAIKYAILIAVVIMLAGGLLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQA 377
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446726807 172 TGDsktPFYFLIVSTALNMILLpiLIFGWLGAPKLDVYGAAYASVISTVITFIVMLLYLKK 232
Cdd:cd13144 378 LGR---GVYSLIISVARQLVVL--LPLAWLLAKMFGLNGVWWSFPIAEIVSFLLSLLFLKR 433
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
72-233 |
9.17e-08 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 54.00 E-value: 9.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 72 FFLLVSFVIGIGSGSSIL--IGQAFGAKNEDRLKAIVGTTLTFTFIIGVVLAIIGSIFAMDIMRLM-----GTPENIIEI 144
Cdd:cd13123 259 LYQLPLGIFGVAIATALLprLSRLAAAGDLDEFRRTLSRGLRLVLFLLLPAAVGLIVLAEPIVRLLfergaFTAEDTLMT 338
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 145 svhyARILFISMPVLFLYFAYTTFMRG---TGDSKTPFYFLIVSTALNmILLPILIFGWLGapkldVYGAAYASVISTVI 221
Cdd:cd13123 339 ----ASALAAYALGLPAFALVKLLSRAfyaLKDTKTPVKIAVIAVAVN-ILLNLLLIKPLG-----HVGLALATSLSAWV 408
|
170
....*....|..
gi 446726807 222 TFIVMLLYLKKK 233
Cdd:cd13123 409 NALLLLVLLRRR 420
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
35-414 |
9.94e-08 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 54.09 E-value: 9.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 35 LLLSNVLQSVGQLFGMVVVGRWLGVNDLAAISAFFPLFFLLVSFVIGigsGSSILIGQAFGAKNEDRLKAIVGTTLTFTF 114
Cdd:cd13128 8 LFVGNIISKLLGFLVRVYLARYLGPEGFGILSLALAFVGLFSIFADL---GLPTALVREIARYRKEKIREIISTSLVLKL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 115 IIGVVLAIIGSIFAMDIMRLMGTPENIIeisvhyaRILFISMPVLFLYFAYTTFMRGTGDSKTPFYFLIVSTALNMILLP 194
Cdd:cd13128 85 ILGILALLLLFLFAFLIAFYDPELVLLL-------YILALSLPFSALNSLFRGIFQGFEKMKYIVIARIIESVLSLILAL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 195 ILIFgwlgaPKLDVYGAAYASVISTVITFIVMLLYLKKKnhplqldGTVRKYLRMDGELLKLLLRLGIPASINMILVSL- 273
Cdd:cd13128 158 ILVL-----LGGGLIGFALAYLIASVLSAILLLYIYRKK-------ILLPKFFSFDLKLAKELLRFSIPLALSGIFSLIy 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 274 SEIAVIAFVNRYGSDATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIgANQFDRLQKVVKAGIIMNYVIGGVLISLIY 353
Cdd:cd13128 226 TRIDTIMLGYFLGDAAVGIYNAAYRIAELLLFIPSAISTALFPRISELY-KNDKDELKKLLKKSFKYLFLISLPIAIGLF 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446726807 354 LFSRDILSLFLTSQTTIEIahSLVMITLWSYLIFGHAQIISATMRASGTVLWPTVIGVVSI 414
Cdd:cd13128 305 LFAEPIITLLFGEEYLPAA--LVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLIGA 363
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
97-456 |
2.61e-07 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 52.84 E-value: 2.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 97 KNEDRLKAIVGTTLTFTFIIGVVLAIIGSIFAMDIMRLM--GTPENIIEISVHYARILFismPVLFLYFAYTTFMrGTGD 174
Cdd:cd13123 65 EGEEEARRFASRVLTLLLLVLLLLTLLGILFAPLLVKLLapGFSGDKFELAVALTRIMF---PYLLFISLSALLG-GILN 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 175 SKTPFYFLIVSTALNMILLPILIFGWLGAPKLDVYGAAYASVISTVITFIVMLLYLKKKNHPLQL-----DGTVRKYLRM 249
Cdd:cd13123 141 AHGRFFAPALAPVLLNLVIIAGLLLLAPLFDLGIYALAWGVLLGGVLQLLVQLPALRRLGFRFRPrldfrDPGVRRVLKL 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 250 dgellklllrlGIPASINMILVSLSEIAVIAFVNRYGSDATAAYGVVNQVasyVQMP----AVSLGITVSIFAAQSIGAN 325
Cdd:cd13123 221 -----------MLPALLGVSVSQINLLVDTILASFLPEGSISALYYADRL---YQLPlgifGVAIATALLPRLSRLAAAG 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 326 QFDRLQKVVKAGIIMNYVIGGVLISLIYLFSRDILSLFL-----TSQTTIEIAHSLVM--ITLWSYLIFghaQIISATMR 398
Cdd:cd13123 287 DLDEFRRTLSRGLRLVLFLLLPAAVGLIVLAEPIVRLLFergafTAEDTLMTASALAAyaLGLPAFALV---KLLSRAFY 363
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 446726807 399 ASGTVLWPTVIGVVSIwLVEVPVAYYLSYhtSLGIEGIWIGYPAAFIVSLILQYAYYK 456
Cdd:cd13123 364 ALKDTKTPVKIAVIAV-AVNILLNLLLIK--PLGHVGLALATSLSAWVNALLLLVLLR 418
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
263-413 |
3.30e-07 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 52.25 E-value: 3.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 263 PASINMILVSLSEIAVIAFVNRYGSDATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGIIMNY 342
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLAL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446726807 343 VIGGVLISLIYLFSRDILSLFLTSQTTIEIAHSLVMITLWSYLIFGHAQIISATMRASGTVLWPTVIGVVS 413
Cdd:TIGR00797 81 LLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIG 151
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
21-232 |
4.33e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 48.64 E-value: 4.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 21 SKPIWKSMSMFLVPLLLSNVLQSVGQLFGMVVVGRWLGVNDLAAISAFFPLFFLLVSFVIGIGSGSSIligQAFGAKNED 100
Cdd:cd13127 194 SLASLKELLSFGSKLLGSNLLNYFSRNLDNLIIGKFLGAAALGYYSRAYRLALLPVQNITGPITRVLF---PALSRLQDD 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 101 --RLKAIVGTTLTFTFIIGVVLAIIGSIFAMDIMRLMGTPEniIEISVHYARILFISMPVLFLYFAYTTFMRGTGDSKTP 178
Cdd:cd13127 271 peRLRRAYLKALRLLALITFPLMVGLALLAEPLVLLLLGEK--WLPAVPILQILALAGLFQPLSSLNGSLLLALGRTDLL 348
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 446726807 179 FYFLIVSTALNMILLPILIFgwlgapkLDVYGAAYASVISTVITFIVMLLYLKK 232
Cdd:cd13127 349 LKLGLIKAVLTVLALLIGIP-------YGIIGVAIAYVIASLLSFPLNLYLAGR 395
|
|
| PRK10367 |
PRK10367 |
DNA-damage-inducible SOS response protein; Provisional |
17-403 |
1.39e-05 |
|
DNA-damage-inducible SOS response protein; Provisional
Pssm-ID: 182413 [Multi-domain] Cd Length: 441 Bit Score: 47.43 E-value: 1.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 17 LESESKPIWKsmsmFLVPLLLSNVLQSVGQLFGMVVVGR-----WLG---VNDLAAISAFFPLFFLLVSfvigigsgSSI 88
Cdd:PRK10367 4 LTSSDKALWR----LALPMIFSNITVPLLGLVDTAVIGHldspvYLGgvaVGATATSFLFMLLLFLRMS--------TTG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 89 LIGQAFGAKNEDRLKAIVGTTLTFTFIIGVVLAIIGSIFAMDIMRLMGTPENIIEISVHYARILFISMPVLFLYFAYTTF 168
Cdd:PRK10367 72 LTAQAFGAKNPQALARALVQPLLLALGAGALIALLRTPLIDLALHIVGGSEAVLEQARRFLEIRWLSAPASLANLVLLGW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 169 MRGTGDSKTPFYFLIVSTALNMILLPILIFGWlgapKLDVYGAAYASVISTVITFIVMLLYLKK--KNHPLQLD------ 240
Cdd:PRK10367 152 LLGVQYARAPVILLVVGNILNIVLDLWLVMGL----HMNVQGAALATVIAEYATLLIGLLMVRKvlKLRGISLEmlktaw 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 241 -GTVRKYLRMDGELLklllrlgipasINMILVSLSEIAVIAFVNRYGSDATAAYGVVNQVASYVQMPAVSLGITVSIFAA 319
Cdd:PRK10367 228 rGNFRRLLALNRDIM-----------LRSLLLQLCFGAITVLGARLGSDIIAVNAVLMTLLTFTAYALDGFAYAVEAHSG 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 320 QSIGANQFDRLQKVVKAGIIMNYVIgGVLISLIY-LFSRDILSLfLTSQTTIEIAHS--------LVMITLWSYLIFGha 390
Cdd:PRK10367 297 QAYGARDGSQLLDVWRAACRQSGIV-ALLFSLVYaLAGEHIIAL-LTSLPQIQQLADryliwqviLPLVGVWCYLLDG-- 372
|
410
....*....|....*..
gi 446726807 391 QIISAT----MRASGTV 403
Cdd:PRK10367 373 MFIGATraaeMRNSMAV 389
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
150-233 |
5.58e-05 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 42.94 E-value: 5.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 150 RILFISMPVLFLYFAYTTFMRGTGDSKTPFYFLIVSTALNMILLPILIfgwlgaPKLDVYGAAYASVISTVITFIVMLLY 229
Cdd:pfam14667 3 QILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKLILNLLLI------PLFGIVGAAIATVISLLVVALLNLYY 76
|
....
gi 446726807 230 LKKK 233
Cdd:pfam14667 77 LRRY 80
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
96-454 |
8.58e-05 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 44.76 E-value: 8.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 96 AKNEDRLKAIVGTTLTFTFIIGVVLAIIGSIFAMDIMRLM--GTPENIIEISVHYARILFismPVLFLYFAYTTFMrGTG 173
Cdd:COG0728 71 KEGEEEARRFASRVLTLLLLVLLVLTLLGILFAPLLVKLLapGFDPEKFALAVALTRIMF---PYILFIGLSALLG-GVL 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 174 DSKTPFYFLIVSTALN--MILLPILIFGWLGAPklDVYGAAYASVISTVITFIVMLLYLKKKNHPLQL-----DGTVRKY 246
Cdd:COG0728 147 NARGRFAAPALAPVLLnlVIIAGLLLLAPLFGP--GIYALAWGVLLGGVLQLLIQLPALRRLGLRLRPrfdlrDPGVRRV 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 247 LRMdgellklllrlGIPASINMILVSLSEIAVIAFVNRYGSDATAAYGVVNQVasyVQMP----AVSLGITVSIFAAQSI 322
Cdd:COG0728 225 LKL-----------MLPALLGVSVSQINLLVDTILASFLPEGSVSALYYADRL---YQLPlglfGVAIGTALLPRLSRAA 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 323 GANQFDRLQKVVKAGIIMNYVIGGVLISLIYLFSRDILSLFL-----TSQTTIEIAHSLVM--ITLWSYLIFghaQIISA 395
Cdd:COG0728 291 AAGDLEEFRRTLSRGLRLVLLLTLPAAVGLIVLAEPIVRLLFergafTAEDTALTALALAAyaLGLPAFALV---KVLAR 367
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 446726807 396 TMRASGTVLWPTVIGVVSIwLVEVPVAYYLSYHtsLGIEGIWIGYPAAFIVSLILQYAY 454
Cdd:COG0728 368 AFYARQDTRTPVRIAVIAV-VVNIVLNLLLVPP--LGHAGLALATSLSALVNALLLLVL 423
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
262-462 |
5.21e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 42.28 E-value: 5.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 262 IPASINMILVSLSEIAVIAFVNRYGSDATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGIIMN 341
Cdd:cd13135 8 IPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDYAISSIVYN 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 342 YVIGGVLISLIYLFSRDILSLFLTSQTTIEIAHSLVMITLWSYLIFGHAQIISATMRASGTVLwPTVIGVVSIWLVEVPV 421
Cdd:cd13135 88 SIIGVILFLLWLFGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETK-PIMYGGIIKNLLNVIL 166
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 446726807 422 AYYLSYHT----SLGIEGIWIGYPAAFIVSLILqYAYYKLSWQKK 462
Cdd:cd13135 167 DYVLIFGNfgfpRLGIIGAAIATTIANVLNLII-LVYLCRKIKKL 210
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
260-464 |
6.50e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 38.75 E-value: 6.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 260 LGIPASINMILVSLSEIAVIAFVNRYGSDATAAYGVVNQVASYVQMPAVSLGITVSIFAAQSIGANQFDRLQKVVKAGII 339
Cdd:cd13144 13 MSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQKEANKAANNGLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 340 MNYVIGGVLISLIYLFSRDILSLFLTSQTTIEIAHSLVMITLWSYLIFGHAQIISATMRASGTVLWPT---VIGVVSIWL 416
Cdd:cd13144 93 LALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMiaqLIGAIINII 172
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 446726807 417 VEVPVAYYLSYHTSLGIEGIWIGYPAAFIVSLIlqYAYYKLSWQKKRI 464
Cdd:cd13144 173 LDPILIFGLFGFPAMGIAGAAIATVIGQILAMF--LAFFFLLRKNKDV 218
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
69-454 |
7.14e-03 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 38.60 E-value: 7.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 69 FPLFFLLVSF-VIGIGSGSSILIGQAFGAKNEDRLKAIVGTTLTFTFIIGVVLAIIGSIFAMDIMRLMgtpeniieISVH 147
Cdd:cd13124 37 YPIYGIFLTLaTAGIPVAISKLVAEYNALGDYKGARRIFRVSLILLLILGLVFFLLLFFGAPFLAQLL--------LGDP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 148 YARILFISMPVLFLYFAYTTFMRGtgdsktpfYF----LIVSTALN-----------MILLPILIFGWLGAPKLDVYGAA 212
Cdd:cd13124 109 RLAPVIRALAPAILIVPLLSVLRG--------YFqglqNMTPTAVSqvieqivrvivILVLAYLLLPVGGGLYYAAAGAT 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 213 YASVISTVITFIVMLLYLKKKNHPLQLDGTVRKYLRMD-GELLKLLLRLGIPASINMILVSLSEIAVIAFVNR------- 284
Cdd:cd13124 181 FGAVIGALAGLLVLLYYYRKKRRELKRLLRKSPRSKIStKEILKELLSYAIPITLSSLILPLLQLIDSFTVPRrlqaagl 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 285 YGSDATAAYGVVNQVA-SYVQMP---AVSLGITVSIFAAQSIGANQFDRLQKVVKAGIIMNYVIGGVLISLIYLFSRDIL 360
Cdd:cd13124 261 SESEATALYGILTGRAqPLVQLPtviATALSTSLVPAISEAYAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPIN 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 361 SLFLTSQTTIEIAHSLVMITLWSYLIfghaQIISATMRASGTVLWPTVIGVVSIwLVEVPVAYYLSYHtsLGIEGIWIGY 440
Cdd:cd13124 341 TLLFGDSEGGLILQILAPSILFLSLQ----QVTAAILQGLGKVKIPVINLLIGL-LVKIVLNYVLIPI--FGIYGAAIAT 413
|
410
....*....|....
gi 446726807 441 PAAFIVSLILQYAY 454
Cdd:cd13124 414 VIGFLVAALLNLRA 427
|
|
| MATE_like_10 |
cd13125 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
96-293 |
8.80e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides, such as O-antigen. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240530 [Multi-domain] Cd Length: 409 Bit Score: 38.29 E-value: 8.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 96 AKNEDRLKAIVGTTLTFTFIIGVVLAIIGSIFAMDImrlmgtpENIIEISVHYARILFISMPVLFLYFAYTTF---MRGT 172
Cdd:cd13125 66 KDDEEKLARVWSTAFRITLILSILGGLLLLLFSKPL-------SSLLFGDIDYSWVFILLGLALPLFALNNLLlaiLNGL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446726807 173 GDSKTPFYFLIVSTALNMILLPILIFGWlgapklDVYGAAYASVISTVITFIVMLLYLKKKNHPLQldgtVRKYLRMDGE 252
Cdd:cd13125 139 KEIKRYALINIISSLIGLLVSVLLVYFY------GLKGALLALVLNQSLIFLVTLIYSRKQPWFKL----KYLWGRLDKD 208
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 446726807 253 LLKLLLRLGIPASINMILVSLSEIAVIAFVNRYGSDATAAY 293
Cdd:cd13125 209 IIKKLLKFSLMALVSALSLPLSQIIVRNILIRQLGWEAAGY 249
|
|
| |
