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Conserved domains on  [gi|446723960|ref|WP_000801273|]
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MULTISPECIES: fimbria biosynthesis transcriptional regulator FimZ [Salmonella]

Protein Classification

response regulator transcription factor FimZ( domain architecture ID 11484526)

two-component system fimbriae biosynthesis transcriptional regulator FimZ binds DNA upon phosphorylation and functions as transcriptional regulator involved in the expression of type I fimbriae

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
1-210 8.83e-143

fimbriae biosynthesis transcriptional regulator FimZ;


:

Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 396.55  E-value: 8.83e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   1 MKPASVIIMDEHPIVRMSIEVLLGKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRI 80
Cdd:PRK09935   1 MKPASVIIMDTHPIIRMSIEVLLQKNSELQIVLKTDDYRITIDYLRTRPVDLIIMDIDLPGTDGFTFLKRIKQIQSTVKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  81 LFLSSKSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMILSGYSFFPSETLNFISNTRTPKGGHHDMPLSNREVTVLRY 160
Cdd:PRK09935  81 LFLSSKSECFYAGRAIQAGANGFVSKCNDQNDIFHAVQMILSGYTFFPSETLNYIKSNKCSTNSSTDTVLSNREVTILRY 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 446723960 161 LANGMSNKEIAEQLLLSNKTISAHKANIFSKLGLHSIVELIDYAKSHELL 210
Cdd:PRK09935 161 LVSGLSNKEIADQLLLSNKTVSAHKSNIYGKLGLHSIVELIDYAKLHELL 210
 
Name Accession Description Interval E-value
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
1-210 8.83e-143

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 396.55  E-value: 8.83e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   1 MKPASVIIMDEHPIVRMSIEVLLGKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRI 80
Cdd:PRK09935   1 MKPASVIIMDTHPIIRMSIEVLLQKNSELQIVLKTDDYRITIDYLRTRPVDLIIMDIDLPGTDGFTFLKRIKQIQSTVKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  81 LFLSSKSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMILSGYSFFPSETLNFISNTRTPKGGHHDMPLSNREVTVLRY 160
Cdd:PRK09935  81 LFLSSKSECFYAGRAIQAGANGFVSKCNDQNDIFHAVQMILSGYTFFPSETLNYIKSNKCSTNSSTDTVLSNREVTILRY 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 446723960 161 LANGMSNKEIAEQLLLSNKTISAHKANIFSKLGLHSIVELIDYAKSHELL 210
Cdd:PRK09935 161 LVSGLSNKEIADQLLLSNKTVSAHKSNIYGKLGLHSIVELIDYAKLHELL 210
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 6-122 7.46e-39

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 129.94  E-value: 7.46e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLGKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSS 85
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446723960  86 KSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMILS 122
Cdd:cd17535   81 HDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAVAA 117
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 3-210 3.35e-33

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 115.76  E-value: 3.35e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   3 PASVIIMDEHPIVRMSIEVLLGKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIksiqehtrilf 82
Cdd:COG2197    1 MIRVLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRL----------- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  83 lsskseafyagrairagangfvskrkdlndiynavkmilsgysffpsetlnfisntrtpkgghhdmpLSNREVTVLRYLA 162
Cdd:COG2197   70 -------------------------------------------------------------------LTPREREVLRLLA 82

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 446723960 163 NGMSNKEIAEQLLLSNKTISAHKANIFSKLGLHSIVELIDYAKSHELL 210
Cdd:COG2197   83 EGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLGLL 130
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 6-118 4.00e-32

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 112.24  E-value: 4.00e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960    6 VIIMDEHPIVRMSIEVLLgkNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSS 85
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLL--EKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTA 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 446723960   86 KSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVK 118
Cdd:pfam00072  79 HGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 147-204 3.38e-21

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 82.57  E-value: 3.38e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 446723960   147 DMPLSNREVTVLRYLANGMSNKEIAEQLLLSNKTISAHKANIFSKLGLHSIVELIDYA 204
Cdd:smart00421   1 LASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
Sig70_bacteroi1 TIGR02985
RNA polymerase sigma-70 factor, Bacteroides expansion family 1; This group of sigma factors ...
 148-187 9.38e-03

RNA polymerase sigma-70 factor, Bacteroides expansion family 1; This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.


Pssm-ID: 274376 [Multi-domain]  Cd Length: 161  Bit Score: 35.62  E-value: 9.38e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 446723960  148 MPLSNREVTVLRYLaNGMSNKEIAEQLLLSNKTISAHKAN 187
Cdd:TIGR02985 114 LPEQCREIFILSRF-EGLSNKEIAEELGISVKTVEYHITK 152
 
Name Accession Description Interval E-value
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
1-210 8.83e-143

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 396.55  E-value: 8.83e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   1 MKPASVIIMDEHPIVRMSIEVLLGKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRI 80
Cdd:PRK09935   1 MKPASVIIMDTHPIIRMSIEVLLQKNSELQIVLKTDDYRITIDYLRTRPVDLIIMDIDLPGTDGFTFLKRIKQIQSTVKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  81 LFLSSKSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMILSGYSFFPSETLNFISNTRTPKGGHHDMPLSNREVTVLRY 160
Cdd:PRK09935  81 LFLSSKSECFYAGRAIQAGANGFVSKCNDQNDIFHAVQMILSGYTFFPSETLNYIKSNKCSTNSSTDTVLSNREVTILRY 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 446723960 161 LANGMSNKEIAEQLLLSNKTISAHKANIFSKLGLHSIVELIDYAKSHELL 210
Cdd:PRK09935 161 LVSGLSNKEIADQLLLSNKTVSAHKSNIYGKLGLHSIVELIDYAKLHELL 210
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
7-209 9.76e-45

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 147.73  E-value: 9.76e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   7 IIMDEHPIVRMSIEVLLGKNsNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSSK 86
Cdd:PRK09958   4 IIIDDHPLAIAAIRNLLIKN-DIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVSAK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  87 SEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMILSGYSFFPSeTLNFISNTRTPKGGHHDmPLSNREVTVLRYLANGMS 166
Cdd:PRK09958  83 NDHFYGKHCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYFPF-SLNRFVGSLTSDQQKLD-SLSKQEISVMRYILDGKD 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 446723960 167 NKEIAEQLLLSNKTISAHKANIFSKLGLHSIVELIDYAKSHEL 209
Cdd:PRK09958 161 NNDIAEKMFISNKTVSTYKSRLMEKLECKSLMDLYTFAQRNKI 203
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 6-122 7.46e-39

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 129.94  E-value: 7.46e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLGKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSS 85
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446723960  86 KSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMILS 122
Cdd:cd17535   81 HDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAVAA 117
PRK15369 PRK15369
two component system response regulator;
1-205 1.30e-33

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 119.41  E-value: 1.30e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   1 MKPASVIIMDEHPIVRMSIEVLLGKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRI 80
Cdd:PRK15369   1 MKNYKILLVDDHELIINGIKNMLAPYPRYKIVGQVDNGLEVYNACRQLEPDIVILDLGLPGMNGLDVIPQLHQRWPAMNI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  81 LFLSSKSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMILSGYSFFPSeTLNFISNTRTPKGGHHDMP-LSNREVTVLR 159
Cdd:PRK15369  81 LVLTARQEEHMASRTLAAGALGYVLKKSPQQILLAAIQTVAVGKRYIDP-ALNREAILALLNADDTNPPlLTPRERQILK 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 446723960 160 YLANGMSNKEIAEQLLLSNKTISAHKANIFSKLGLHSIVELIDYAK 205
Cdd:PRK15369 160 LITEGYTNRDIAEQLSISIKTVETHRLNMMRKLDVHKVAELLNWAR 205
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 3-210 3.35e-33

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 115.76  E-value: 3.35e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   3 PASVIIMDEHPIVRMSIEVLLGKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIksiqehtrilf 82
Cdd:COG2197    1 MIRVLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRL----------- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  83 lsskseafyagrairagangfvskrkdlndiynavkmilsgysffpsetlnfisntrtpkgghhdmpLSNREVTVLRYLA 162
Cdd:COG2197   70 -------------------------------------------------------------------LTPREREVLRLLA 82

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 446723960 163 NGMSNKEIAEQLLLSNKTISAHKANIFSKLGLHSIVELIDYAKSHELL 210
Cdd:COG2197   83 EGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLGLL 130
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 6-118 4.00e-32

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 112.24  E-value: 4.00e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960    6 VIIMDEHPIVRMSIEVLLgkNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSS 85
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLL--EKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTA 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 446723960   86 KSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVK 118
Cdd:pfam00072  79 HGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
PRK09483 PRK09483
response regulator; Provisional
 5-210 1.06e-29

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 109.43  E-value: 1.06e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   5 SVIIMDEHPIVRMSIEVLLGKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLS 84
Cdd:PRK09483   3 NVLLVDDHELVRAGIRRILEDIKGIKVVGEACCGEDAVKWCRTNAVDVVLMDMNMPGIGGLEATRKILRYTPDVKIIMLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  85 SKSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMILSGYSFFPSETL------NFISNTRTPKGGhhdmpLSNREVTVL 158
Cdd:PRK09483  83 VHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVHSGQRYIASDIAqqmalsQIEPATENPFAS-----LSERELQIM 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446723960 159 RYLANGMSNKEIAEQLLLSNKTISAHKANIFSKLGLHSIVELIDYAKSHELL 210
Cdd:PRK09483 158 LMITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNISGDVELTHLAIRHGLL 209
PRK10360 PRK10360
transcriptional regulator UhpA;
5-200 1.43e-28

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 105.83  E-value: 1.43e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   5 SVIIMDEHPIVRMSIEVLLGKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSiqeHTRILFLS 84
Cdd:PRK10360   3 TVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPK---GMATIMLS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  85 SKSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMILSGYSFF-PSETLNFISNTRTPkgghhdmpLSNREVTVLRYLAN 163
Cdd:PRK10360  80 VHDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLtPDIAIKLASGRQDP--------LTKRERQVAEKLAQ 151

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 446723960 164 GMSNKEIAEQLLLSNKTISAHKANIFSKLGLHSIVEL 200
Cdd:PRK10360 152 GMAVKEIAAELGLSPKTVHVHRANLMEKLGVSNDVEL 188
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 5-106 4.23e-25

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 94.07  E-value: 4.23e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   5 SVIIMDEHPIVRMSIEVLLGKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLS 84
Cdd:COG4753    1 KVLIVDDEPLIREGLKRILEWEAGFEVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIILS 80

                         90       100
                 ....*....|....*....|..
gi 446723960  85 SKSEAFYAGRAIRAGANGFVSK 106
Cdd:COG4753   81 GYSDFEYAQEAIKLGADDYLLK 102
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 2-199 2.18e-24

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 95.48  E-value: 2.18e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   2 KPASVIIMDEHPIVRMSIEVLLGKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRIL 81
Cdd:PRK10651   5 EPATILLIDDHPMLRTGVKQLISMAPDITVVGEASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSLSGRIV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  82 FLSSKSEAFYAGRAIRAGANGFVSKRKDLNDIYNAV------KMILsgysffpSETLNFI--SNTR--TPKGGHHDMPLS 151
Cdd:PRK10651  85 VFSVSNHEEDVVTALKRGADGYLLKDMEPEDLLKALqqaaagEMVL-------SEALTPVlaASLRanRATTERDVNQLT 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 446723960 152 NREVTVLRYLANGMSNKEIAEQLLLSNKTISAHKANIFSKLGLHSIVE 199
Cdd:PRK10651 158 PRERDILKLIAQGLPNKMIARRLDITESTVKVHVKHMLKKMKLKSRVE 205
PRK10840 PRK10840
transcriptional regulator RcsB; Provisional
 1-206 1.81e-23

transcriptional regulator RcsB; Provisional


Pssm-ID: 182771 [Multi-domain]  Cd Length: 216  Bit Score: 92.97  E-value: 1.81e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   1 MKPASVIIMDEHPIVRMSIEVLLGKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGT---DGFTLLKRIKSIQEH 77
Cdd:PRK10840   1 MNNMNVIIADDHPIVLFGIRKSLEQIEWVNVVGEFEDSTALINNLPKLDAHVLITDLSMPGDkygDGITLIKYIKRHFPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  78 TRILFLSSKSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMILSGYSFFPSETLNFISNTRtpKGGHHDMPLSNREVTV 157
Cdd:PRK10840  81 LSIIVLTMNNNPAILSAVLDLDIEGIVLKQGAPTDLPKALAALQKGKKFTPESVSRLLEKIS--AGGYGDKRLSPKESEV 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 446723960 158 LRYLANGMSNKEIAEQLLLSNKTISAHKANIFSKLGLHSIVELIDYAKS 206
Cdd:PRK10840 159 LRLFAEGFLVTEIAKKLNRSIKTISSQKKSAMMKLGVENDIALLNYLSS 207
GerE pfam00196
Bacterial regulatory proteins, luxR family;
148-204 2.70e-23

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 88.03  E-value: 2.70e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 446723960  148 MPLSNREVTVLRYLANGMSNKEIAEQLLLSNKTISAHKANIFSKLGLHSIVELIDYA 204
Cdd:pfam00196   1 DSLSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRMA 57
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 3-198 1.47e-22

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 90.40  E-value: 1.47e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   3 PASVIIMDEHPIVRMSIEVLLGKNsNIQVVLkTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILF 82
Cdd:COG0745    1 MPRILVVEDDPDIRELLADALERE-GYEVDT-AADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIM 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  83 LSSKSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMILSGYSFFPSETLNFI-SNTRTPKGGHHDMPLSNREVTVLRYL 161
Cdd:COG0745   79 LTARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRRAAEVLRVGDLLdLAAREVTRDGEPVELTPKEFRLLELL 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 446723960 162 AN----GMSNKEIAEQL----LLSNKTISAHKANIFSKLGLHSIV 198
Cdd:COG0745  159 MRnpgrVVSREQLLEEVwgydYGDDRTVDVHISRLRKKLEDDLIE 203
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 1-125 2.13e-22

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 87.98  E-value: 2.13e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   1 MKPASVIIMDEHPIVRMSIEVLLgKNSNIQVVLkTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQE--HT 78
Cdd:COG0784    3 LGGKRILVVDDNPDNRELLRRLL-ERLGYEVTT-AEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIRALPRlpDI 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 446723960  79 RILFLSSKSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMILSGYS 125
Cdd:COG0784   81 PIIALTAYADEEDRERALEAGADDYLTKPVDPEELLEALRRLLARAS 127
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 3-106 3.74e-22

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 88.81  E-value: 3.74e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   3 PASVIIMDEHPIVRMSIEVLLGKNsNIQVVLkTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQE--HTRI 80
Cdd:COG3706    1 PARILVVDDDPTNRKLLRRLLEAA-GYEVVE-AADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLRADPRtaDIPI 78

                         90       100
                 ....*....|....*....|....*.
gi 446723960  81 LFLSSKSEAFYAGRAIRAGANGFVSK 106
Cdd:COG3706   79 IFLTALDDEEDRARALEAGADDYLTK 104
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 147-204 3.38e-21

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 82.57  E-value: 3.38e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 446723960   147 DMPLSNREVTVLRYLANGMSNKEIAEQLLLSNKTISAHKANIFSKLGLHSIVELIDYA 204
Cdd:smart00421   1 LASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
3-198 9.44e-21

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 86.06  E-value: 9.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   3 PASVIIMDEHPIVRMSIEVLLGKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLK--RIKSIQEHTRI 80
Cdd:PRK10403   6 PFQVLIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDPDVILLDLNMKGMSGLDTLNalRRDGVTAQIII 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  81 LFLSSKSEAFYAgrAIRAGANGFVSKRKDLNDIYNAVKMILSGYSFFpSETLNFISNTRTPKGGHHD--MPLSNREVTVL 158
Cdd:PRK10403  86 LTVSDASSDVFA--LIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVF-SERVNQYLREREMFGAEEDpfSVLTERELDVL 162

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 446723960 159 RYLANGMSNKEIAEQLLLSNKTISAHKANIFSKLGLHSIV 198
Cdd:PRK10403 163 HELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRV 202
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 6-201 1.42e-20

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 84.77  E-value: 1.42e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLgKNSNIQVvlKTDDSrtAIEYLRTYPVDL---VILDIELPGTDGFTLLKRIKSIQEHTRILF 82
Cdd:COG4566    2 VYIVDDDEAVRDSLAFLL-ESAGLRV--ETFAS--AEAFLAALDPDRpgcLLLDVRMPGMSGLELQEELAARGSPLPVIF 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  83 LSSKSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKmilsgysffpsETLNFISNTRTPKGGHHDM-----PLSNREVTV 157
Cdd:COG4566   77 LTGHGDVPMAVRAMKAGAVDFLEKPFDDQALLDAVR-----------RALARDRARRAERARRAELrarlaSLTPREREV 145

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 446723960 158 LRYLANGMSNKEIAEQLLLSNKTISAHKANIFSKLGLHSIVELI 201
Cdd:COG4566  146 LDLVVAGLSNKQIARELGISPRTVEVHRANVMEKLGARSLAELV 189
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 8-106 2.53e-20

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 81.50  E-value: 2.53e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   8 IMDEHPIVRMSIEVLLgKNSNIQVVLkTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSSKS 87
Cdd:cd00156    2 IVDDDPAIRELLKSLL-EREGYEVDT-AADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTAKA 79

                         90
                 ....*....|....*....
gi 446723960  88 EAFYAGRAIRAGANGFVSK 106
Cdd:cd00156   80 DEEDAVRALELGADDYLVK 98
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-106 2.56e-20

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 82.71  E-value: 2.56e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   1 MKPASVIIMDEHPIVRMSIEVLLGKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRI 80
Cdd:COG4565    1 MKMIRVLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDV 80

                         90       100
                 ....*....|....*....|....*.
gi 446723960  81 LFLSSKSEAFYAGRAIRAGANGFVSK 106
Cdd:COG4565   81 IVITAARDPETVREALRAGVVDYLIK 106
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 2-106 2.05e-19

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 82.52  E-value: 2.05e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   2 KPASVIIMDEHPIVRMSIEVLLgKNSNIQVVLkTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQE--HTR 79
Cdd:COG3437    5 QAPTVLIVDDDPENLELLRQLL-RTLGYDVVT-AESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLRADPStrDIP 82

                         90       100
                 ....*....|....*....|....*..
gi 446723960  80 ILFLSSKSEAFYAGRAIRAGANGFVSK 106
Cdd:COG3437   83 VIFLTALADPEDRERALEAGADDYLTK 109
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 6-120 3.05e-19

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 79.30  E-value: 3.05e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLGKNS-NIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLS 84
Cdd:cd17536    1 VLIVDDEPLIREGLKKLIDWEElGFEVVGEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIIILS 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446723960  85 SKSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMI 120
Cdd:cd17536   81 GYDDFEYAQKAIRLGVVDYLLKPVDEEELEEALEKA 116
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 150-206 3.75e-19

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 77.19  E-value: 3.75e-19
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446723960 150 LSNREVTVLRYLANGMSNKEIAEQLLLSNKTISAHKANIFSKLGLHSIVELIDYAKS 206
Cdd:cd06170    1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYAIR 57
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 2-121 3.87e-19

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 84.24  E-value: 3.87e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   2 KPASVIIMDEHPIVRMSIEVLLGKNsNIQVVLkTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRIL 81
Cdd:COG2204    1 SMARILVVDDDPDIRRLLKELLERA-GYEVET-AASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVI 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 446723960  82 FLSSKSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMIL 121
Cdd:COG2204   79 LLTGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERAL 118
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 6-100 3.21e-18

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 79.48  E-value: 3.21e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEhPIVRMSIEVLLGKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSS 85
Cdd:COG3279    5 LIVDDE-PLARERLERLLEKYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIFTTA 83

                         90
                 ....*....|....*
gi 446723960  86 KSEafYAGRAIRAGA 100
Cdd:COG3279   84 YDE--YALEAFEVNA 96
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 7-106 1.36e-17

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 74.37  E-value: 1.36e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   7 IIMDEHPIVRMsIEVLLgKNSNIQVVLKTDdSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSSK 86
Cdd:cd17574    2 VVEDDEEIAEL-LSDYL-EKEGYEVDTAAD-GEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTAK 78

                         90       100
                 ....*....|....*....|
gi 446723960  87 SEAFYAGRAIRAGANGFVSK 106
Cdd:cd17574   79 DEEEDKVLGLELGADDYITK 98
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 6-121 1.03e-16

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 72.69  E-value: 1.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLGKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSS 85
Cdd:cd19930    1 VLIAEDQEMVRGALAALLELEDDLEVVAQASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAELREELPDTKVLIVTT 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446723960  86 KSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMIL 121
Cdd:cd19930   81 FGRPGYFRRALAAGVDGYVLKDRPIEELADAIRTVH 116
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
149-210 1.74e-15

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 71.33  E-value: 1.74e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446723960 149 PLSNREVTVLRYLANGMSNKEIAEQLLLSNKTISAHKANIFSKLGLHSIVELIDYAKSHELL 210
Cdd:COG2771  127 GLTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSSRAELVALALRLGLI 188
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 145-210 1.55e-14

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 65.75  E-value: 1.55e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446723960 145 HHDMPLSNREVTVLRYLANGMSNKEIAEQLLLSNKTISAHKANIFSKLGLHSIVELIDYAKSHELL 210
Cdd:COG5905    8 SHPSLLTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNRVQAVVWALRLGLL 73
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-122 2.46e-14

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 68.44  E-value: 2.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   1 MKPASVIIMDEHPIVRMSIEVLLgKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRI 80
Cdd:COG3707    1 MRGLRVLVVDDEPLRRADLREGL-REAGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPAPVI 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 446723960  81 LFLSSKSEAFYAgRAIRAGANGFVSKRKDLNDIYNAVKMILS 122
Cdd:COG3707   80 LLTAYSDPELIE-RALEAGVSAYLVKPLDPEDLLPALELALA 120
PRK11475 PRK11475
DNA-binding transcriptional activator BglJ; Provisional
 79-204 1.44e-13

DNA-binding transcriptional activator BglJ; Provisional


Pssm-ID: 236915 [Multi-domain]  Cd Length: 207  Bit Score: 66.69  E-value: 1.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  79 RILFLSSKSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMILSGysffpseTLNFISNTRTPKGGHHDMPLSNREVTVL 158
Cdd:PRK11475  71 RLVIADDDIEARLIGSLSPSPLDGVLSKASTLEILQQELFLSLNG-------VRQATDRLNNQWYINQSRMLSPTEREIL 143

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 446723960 159 RYLANGMSNKEIAEQLLLSNKTISAHKANIFSKLGLHSIVELIDYA 204
Cdd:PRK11475 144 RFMSRGYSMPQIAEQLERNIKTIRAHKFNVMSKLGVSSDAGLLDAA 189
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 6-121 1.51e-13

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 64.22  E-value: 1.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLGKNsNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSS 85
Cdd:cd17542    3 VLIVDDAAFMRMMLKDILTKA-GYEVVGEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVIMCSA 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446723960  86 KSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMIL 121
Cdd:cd17542   82 MGQEEMVKEAIKAGAKDFIVKPFQPERVLEAVEKVL 117
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 4-118 1.78e-13

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 64.14  E-value: 1.78e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   4 ASVIIMDEHPIVRMSIEVLLgKNSNIQVvLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFL 83
Cdd:cd17555    1 ATILVIDDDEVVRESIAAYL-EDSGFQV-LQAADGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITKESPDTPVIVV 78

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446723960  84 SSKSEAFYAGRAIRAGANGFVSKR-KDLNDIYNAVK 118
Cdd:cd17555   79 SGAGVMSDAVEALRLGAWDYLTKPiEDLAVLEHAVR 114
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 4-106 2.42e-13

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 64.00  E-value: 2.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   4 ASVIIMDEHPIVRMSIEVLLGKNSNIQVVLkTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTR--IL 81
Cdd:cd17551    1 MRILIVDDNPTNLLLLEALLRSAGYLEVVS-FTDPREALAWCRENPPDLILLDYMMPGMDGLEFIRRLRALPGLEDvpIV 79

                         90       100
                 ....*....|....*....|....*
gi 446723960  82 FLSSKSEAFYAGRAIRAGANGFVSK 106
Cdd:cd17551   80 MITADTDREVRLRALEAGATDFLTK 104
fixJ PRK09390
response regulator FixJ; Provisional
 4-201 2.54e-13

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 65.79  E-value: 2.54e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   4 ASVIIMDEHPIVRMSIEVLLGkNSNIQVVLKtdDSRTA-IEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILF 82
Cdd:PRK09390   4 GVVHVVDDDEAMRDSLAFLLD-SAGFEVRLF--ESAQAfLDALPGLRFGCVVTDVRMPGIDGIELLRRLKARGSPLPVIV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  83 LSSKSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMILSgysffpsetlnfisnTRTPKGGHHDM---------PLSNR 153
Cdd:PRK09390  81 MTGHGDVPLAVEAMKLGAVDFIEKPFEDERLIGAIERALA---------------QAPEAAKSEAVaadirariaSLSER 145

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 446723960 154 EVTVLRYLANGMSNKEIAEQLLLSNKTISAHKANIFSKLGLHSIVELI 201
Cdd:PRK09390 146 ERQVMDGLVAGLSNKVIARDLDISPRTVEVYRANVMTKMQAGSLSELV 193
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
159-210 5.92e-13

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 64.34  E-value: 5.92e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446723960 159 RYLANGMSNKEIAEQLLLSNKTISAHKANIFSKLGLHSIVELIDYAKSHELL 210
Cdd:COG2909  132 RLLAEGLSNKEIAERLFISVNTVKTHLRNIYRKLGVRSRTEAVARARELGLL 183
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 6-106 1.59e-12

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 62.02  E-value: 1.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLGKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEhTRILFLSS 85
Cdd:cd17541    3 VLIVDDSAVMRKLLSRILESDPDIEVVGTARDGEEALEKIKELKPDVITLDIEMPVMDGLEALRRIMAERP-TPVVMVSS 81

                         90       100
                 ....*....|....*....|...
gi 446723960  86 --KSEAFYAGRAIRAGANGFVSK 106
Cdd:cd17541   82 ltEEGAEITLEALELGAVDFIAK 104
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 6-106 2.53e-12

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 60.59  E-value: 2.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLGKNSniQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSiQEHTR---ILF 82
Cdd:cd17538    2 ILVVDDEPANRELLEALLSAEG--YEVLTADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRLKE-DPETRhipVIM 78

                         90       100
                 ....*....|....*....|....
gi 446723960  83 LSSKSEAFYAGRAIRAGANGFVSK 106
Cdd:cd17538   79 ITALDDREDRIRGLEAGADDFLSK 102
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 6-117 3.86e-12

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 60.56  E-value: 3.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLGKnSNIQVVLkTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIK---SIQEHTRILF 82
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLLEK-LGYEVDV-AENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIReleGGGRRTPIIA 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 446723960  83 LSSKSEAFYAGRAIRAGANGFVSKRKDLNDIYNAV 117
Cdd:cd17546   79 LTANALEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 7-121 1.08e-11

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 59.34  E-value: 1.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   7 IIMDEhPIVRMSIEVLLgKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGT-DGFTLLKRIKSIQeHTRILFLSS 85
Cdd:cd17534    5 IVEDE-AIIALDLKEIL-ESLGYEVVGIADSGEEAIELAEENKPDLILMDINLKGDmDGIEAAREIREKF-DIPVIFLTA 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446723960  86 KSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMIL 121
Cdd:cd17534   82 YSDEETLERAKETNPYGYLVKPFNERELKAAIELAL 117
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 6-106 3.77e-11

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 57.77  E-value: 3.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLgKNSNIQVVlKTDDSRTAIEYL---------RTYPVDLVILDIELPGTDGFTLLKRIKSIQE 76
Cdd:cd19924    1 ILVVDDSPTARKQLRDLL-KNLGFEIA-EAVDGEEALNKLenlakegndLSKELDLIITDIEMPKMDGYELTFELRDDPR 78

                         90       100       110
                 ....*....|....*....|....*....|..
gi 446723960  77 HTRI--LFLSSKSEAFYAGRAIRAGANGFVSK 106
Cdd:cd19924   79 LANIpvILNSSLSGEFSRARGKKVGADAYLAK 110
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 6-122 5.90e-11

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 57.36  E-value: 5.90e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLGKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLS- 84
Cdd:cd19931    1 VLLIDDHPLLRKGIKQLIELDPDFTVVGEASSGEEGIELAERLDPDLILLDLNMKGMSGLDTLKALREEGVSARIVILTv 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 446723960  85 --SKSEAFyagRAIRAGANGFVSKRKDLNDIYNAVKMILS 122
Cdd:cd19931   81 sdAEDDVV---TALRAGADGYLLKDMEPEDLLEALKQAAS 117
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 37-106 5.91e-11

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 57.23  E-value: 5.91e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  37 DSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSSKSEAFYAGRAIRAGANGFVSK 106
Cdd:cd17625   29 DGEEGLEYALSGIYDLIILDIMLPGMDGLEVLKSLREEGIETPVLLLTALDAVEDRVKGLDLGADDYLPK 98
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 36-86 1.31e-10

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 55.91  E-value: 1.31e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446723960  36 DDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSSK 86
Cdd:cd19935   29 YDGEDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLRAAGKQTPVLMLTAR 79
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 32-106 1.66e-10

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 55.98  E-value: 1.66e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446723960  32 VLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSiQEHTR---ILFLSSKSEAFYAGRAIRAGANGFVSK 106
Cdd:cd19920   25 VLVATDGQQALQRAQAEPPDLILLDVMMPGMDGFEVCRRLKA-DPATRhipVIFLTALTDTEDKVKGFELGAVDYITK 101
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 6-122 2.54e-10

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 55.88  E-value: 2.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLgKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSiQEHTRILFLSS 85
Cdd:cd19932    3 VLIAEDEALIRMDLREML-EEAGYEVVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITS-ENIAPIVLLTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446723960  86 KSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMILS 122
Cdd:cd19932   81 YSQQDLVERAKEAGAMAYLVKPFSESDLIPAIEMAIA 117
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 32-118 3.15e-10

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 55.62  E-value: 3.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  32 VLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQE--HTRILFLSSkseafYA-----GRAIRAGANGFV 104
Cdd:cd17548   26 VLEAADGEEALEIARKEKPDLILMDIQLPGMDGLEATRLLKEDPAtrDIPVIALTA-----YAmkgdrEKILEAGCDGYI 100

                         90
                 ....*....|....
gi 446723960 105 SKRKDLNDIYNAVK 118
Cdd:cd17548  101 SKPIDTREFLETVA 114
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 37-106 3.81e-10

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 54.76  E-value: 3.81e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  37 DSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSiQEHTRILFLSSKSEAFYAGRAIRAGANGFVSK 106
Cdd:cd19936   30 DGASALDGLNARPPDLAILDIKMPRMDGMELLQRLRQ-KSTLPVIFLTSKDDEIDEVFGLRMGADDYITK 98
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 6-82 8.24e-10

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 54.47  E-value: 8.24e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446723960   6 VIIMDEHPIVRMSIEVLLGKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILF 82
Cdd:cd17532    1 ALIVDDEPLAREELRYLLEEHPDIEIVGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLSKLAKPPLIVF 77
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 5-106 1.23e-09

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 53.88  E-value: 1.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   5 SVIIMDEHPIVRMSIEVLLGKNsNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKS--IQEHTRILF 82
Cdd:cd19923    2 KVLVVDDFSTMRRIIKNLLKEL-GFNNVEEAEDGVDALEKLKAGGFDFVITDWNMPNMDGLELLKTIRAdgALSHLPVLM 80

                         90       100
                 ....*....|....*....|....
gi 446723960  83 LSSKSEAFYAGRAIRAGANGFVSK 106
Cdd:cd19923   81 VTAEAKKENVIAAAQAGVNNYIVK 104
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 4-106 1.44e-09

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 53.54  E-value: 1.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   4 ASVIIMDEHPIVRMSIEVLLGKNSniQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSiQEHTRILFL 83
Cdd:cd17619    1 PHILIVEDEPVTRATLKSYFEQEG--YDVSEAGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELRE-QSEVGIILV 77

                         90       100
                 ....*....|....*....|...
gi 446723960  84 SSKSEAFYAGRAIRAGANGFVSK 106
Cdd:cd17619   78 TGRDDEVDRIVGLEIGADDYVTK 100
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 7-106 1.63e-09

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 53.43  E-value: 1.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   7 IIMDEHPIVRMsIEVLLGKNSNiqVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTR--ILFLS 84
Cdd:cd19937    2 VVDDEEDIVEL-LKYNLEKEGY--EVVTAYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILRSDPKTSSipIIMLT 78

                         90       100
                 ....*....|....*....|..
gi 446723960  85 SKSEAFYAGRAIRAGANGFVSK 106
Cdd:cd19937   79 AKGEEFDKVLGLELGADDYITK 100
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 6-117 1.96e-09

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 53.23  E-value: 1.96e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLGKNSniQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQ--EHTRILFL 83
Cdd:cd17580    1 ILVVDDNEDAAEMLALLLELEG--AEVTTAHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLRELPwlANTPAIAL 78

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446723960  84 SSkseafYAG-----RAIRAGANGFVSKRKDLNDIYNAV 117
Cdd:cd17580   79 TG-----YGQpedreRALEAGFDAHLVKPVDPDELIELI 112
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 6-118 3.30e-09

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 52.94  E-value: 3.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLlgkNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSS 85
Cdd:cd17553    4 LIVDDQYGIRILLNEVF---NKEGYQTFQAANGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTA 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 446723960  86 KSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVK 118
Cdd:cd17553   81 YGELDMIQESKELGALTHFAKPFDIDEIRDAVK 113
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 4-106 4.98e-09

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 52.30  E-value: 4.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   4 ASVIIMDEHPIVRMSIEVLLgKNSNIQVVLKTDdSRTAIEYLRTYPVDLVILDIELPGTDGFTLLK--RIKSIQEHTRIL 81
Cdd:cd17562    1 KKILAVDDSASIRQMVSFTL-RGAGYEVVEAAD-GRDALSKAQSKKFDLIITDQNMPNMDGIELIKelRKLPAYKFTPIL 78

                         90       100
                 ....*....|....*....|....*..
gi 446723960  82 FLSSKS-EAFYA-GRAirAGANGFVSK 106
Cdd:cd17562   79 MLTTESsDEKKQeGKA--AGATGWLVK 103
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 36-117 5.41e-09

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 53.38  E-value: 5.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  36 DDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLS---SKSEAFyagRAIRAGANGFVSKRKDLND 112
Cdd:COG4567   35 ASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVVLTgyaSIATAV---EAIKLGADDYLAKPADADD 111


                 ....*
gi 446723960 113 IYNAV 117
Cdd:COG4567  112 LLAAL 116
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 41-120 5.64e-09

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 52.42  E-value: 5.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  41 AIEYLR--------TYPvDLVILDIELPGTDGFTLLKRIKSiQEHTR----ILFLSSKSE----AFYAgrairAGANGFV 104
Cdd:cd17557   37 ALDFLRgegeyadaPRP-DLILLDLNMPRMDGFEVLREIKA-DPDLRripvVVLTTSDAEedieRAYE-----LGANSYI 109

                         90
                 ....*....|....*.
gi 446723960 105 SKRKDLNDIYNAVKMI 120
Cdd:cd17557  110 VKPVDFEEFVEAIRSL 125
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 6-106 8.73e-09

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 51.61  E-value: 8.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLlgKNSNIQVVLKTDDSRtAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSiQEHTRILFLSS 85
Cdd:cd19939    3 LIVEDELELARLTRDYL--IKAGLEVSVFTDGQR-AVRRIIDEQPSLVVLDIMLPGMDGLTVCREVRE-HSHVPILMLTA 78

                         90       100
                 ....*....|....*....|.
gi 446723960  86 KSEAFYAGRAIRAGANGFVSK 106
Cdd:cd19939   79 RTEEMDRVLGLEMGADDYLCK 99
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 32-120 1.06e-08

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 51.45  E-value: 1.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  32 VLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSSKSEafYAGRAIRAGANGFVSKRKDLN 111
Cdd:cd17554   27 VVTAGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPDLPVIICTAYSE--YKSDFSSWAADAYVVKSSDLT 104


                 ....*....
gi 446723960 112 DIYNAVKMI 120
Cdd:cd17554  105 ELKETIKRL 113
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 6-106 1.37e-08

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 51.37  E-value: 1.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLgKNSNIQVvLKTDDSRTAIEYLRTYP-VDLVILDIELPGTDGFTLLKRIKsiQEHTR----I 80
Cdd:cd17544    3 VLVVDDSATSRNHLRALL-RRHNFQV-LEAANGQEALEVLEQHPdIKLVITDYNMPEMDGFELVREIR--KKYSRdqlaI 78

                         90       100
                 ....*....|....*....|....*.
gi 446723960  81 LFLSSKSEAFYAGRAIRAGANGFVSK 106
Cdd:cd17544   79 IGISASGDNALSARFIKAGANDFLTK 104
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
1-121 1.89e-08

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 53.23  E-value: 1.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   1 MKPASVIIMDEHPIVRMSIEVLLGKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIksIQEH-TR 79
Cdd:PRK00742   1 MMKIRVLVVDDSAFMRRLISEILNSDPDIEVVGTAPDGLEAREKIKKLNPDVITLDVEMPVMDGLDALEKI--MRLRpTP 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 446723960  80 ILFLSS--KSEAFYAGRAIRAGANGFVSKRK--DLNDIYNAVKMIL 121
Cdd:PRK00742  79 VVMVSSltERGAEITLRALELGAVDFVTKPFlgISLGMDEYKEELA 124
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 6-106 2.06e-08

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 50.71  E-value: 2.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMsIEVLLgKNSNIQVVlKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIK--SIQEHTRILFL 83
Cdd:cd17618    4 LIVEDEPAIREM-IAFNL-ERAGFDVV-EAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLKrdEMTRDIPIIML 80

                         90       100
                 ....*....|....*....|...
gi 446723960  84 SSKSEAFYAGRAIRAGANGFVSK 106
Cdd:cd17618   81 TARGEEEDKVRGLEAGADDYITK 103
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 6-106 2.10e-08

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 50.49  E-value: 2.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLgkNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSS 85
Cdd:cd17616    1 VLLIEDDSATAQSIELML--KSEGFNVYTTDLGEEGLDLGKLYDYDIILLDLNLPDMSGYEVLRTLRLAKVKTPILILSG 78

                         90       100
                 ....*....|....*....|.
gi 446723960  86 KSEAFYAGRAIRAGANGFVSK 106
Cdd:cd17616   79 LADIEDKVKGLGFGADDYMTK 99
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
 8-106 7.01e-08

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 48.81  E-value: 7.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   8 IMDEHPIVRMSIEVLLGKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSSKS 87
Cdd:cd17565    3 IVDDDKNIIKILSDIIEDDDLGEVVGEADNGAQAYDEILFLQPDIVLIDLLMPGMDGIQLVRKLKDTGSNGKFIMISQVS 82

                         90
                 ....*....|....*....
gi 446723960  88 EAFYAGRAIRAGANGFVSK 106
Cdd:cd17565   83 DKEMIGKAYQAGIEFFINK 101
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 31-106 7.46e-08

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 49.20  E-value: 7.46e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446723960  31 VVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSSKSEAFYAGRAIRAGANGFVSK 106
Cdd:cd19934   24 VVDVAEDGEEALFQGEEEPYDLVVLDLGLPGMDGLSVLRRWRSEGRATPVLILTARDSWQDKVEGLDAGADDYLTK 99
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 5-60 9.76e-08

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 47.18  E-value: 9.76e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 446723960     5 SVIIMDEHPIVRMSIEVLLGKnSNIQVVLkTDDSRTAIEYLRTYPVDLVILDIELP 60
Cdd:smart00448   2 RILVVDDDPLLRELLKALLEK-EGYEVDE-ATDGEEALELLKEEKPDLILLDIMMP 55
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
 6-106 1.00e-07

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 48.52  E-value: 1.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLGkNSNIQVVLKTDDSRtAIEYLRTYPVDLVILDIELPGTDGFTL--LKRIKSIQEHTRILFL 83
Cdd:cd17602    1 VACVDDRPSIQKMIEYFLE-KQGFRVVVIDDPLR-ALTTLLNSKPDLILIDIDMPDLDGYELcsLLRKSSALKDTPIIML 78

                         90       100
                 ....*....|....*....|...
gi 446723960  84 SSKSEAFYAGRAIRAGANGFVSK 106
Cdd:cd17602   79 TGKDGLVDRIRAKMAGASGYLTK 101
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 6-106 1.06e-07

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 48.31  E-value: 1.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLGKNsniQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEhTRILFLSS 85
Cdd:cd17620    2 LVIEDEPQIRRFLRTALEAHG---YRVFEAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRRLREWSA-VPVIVLSA 77

                         90       100
                 ....*....|....*....|.
gi 446723960  86 KSEAFYAGRAIRAGANGFVSK 106
Cdd:cd17620   78 RDEESDKIAALDAGADDYLTK 98
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 6-100 1.22e-07

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 48.39  E-value: 1.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLGKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSS 85
Cdd:cd19925    3 VLIVEDDPMVAEIHRAYVEQVPGFTVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVVTA 82

                         90
                 ....*....|....*
gi 446723960  86 KSEAFYAGRAIRAGA 100
Cdd:cd19925   83 ANDVETVREALRLGV 97
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 32-81 1.63e-07

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 48.17  E-value: 1.63e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446723960  32 VLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHT-RIL 81
Cdd:cd17569   27 VLTATSGEEALEILKQEPVDVVISDQRMPGMDGAELLKRVRERYPDTvRIL 77
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 40-116 1.81e-07

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 47.82  E-value: 1.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  40 TAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSSkseafYAG-----RAIRAGANGFVSKRKDLNDIY 114
Cdd:cd17563   35 EALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVVLTG-----YASiatavEAIKLGADDYLAKPADADEIL 109


                 ..
gi 446723960 115 NA 116
Cdd:cd17563  110 AA 111
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 37-106 1.99e-07

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 48.12  E-value: 1.99e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  37 DSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSSKSEAFYAGRAIRAGANGFVSK 106
Cdd:cd17615   31 DGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPDVPVLFLTAKDSVEDRIAGLTAGGDDYVTK 100
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 17-121 2.32e-07

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 47.66  E-value: 2.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  17 MSIEVLLGKN---SNIQVVLKTDDSRTAIEYLRtYPVDLVILDIELPGTDGFTLLKRIKSIQeHTRILFLSSKSEAFYAG 93
Cdd:cd18159    8 ETIASLLKKHlekWGYEVVLIEDFEDVLEEFLQ-FKPDLVLLDINLPYFDGFYWCREIRQIS-NVPIIFISSRDDNMDQV 85

                         90       100
                 ....*....|....*....|....*...
gi 446723960  94 RAIRAGANGFVSKRKDLNDIYNAVKMIL 121
Cdd:cd18159   86 MAINMGGDDYITKPFDLDVLLAKIKAIL 113
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 4-118 3.46e-07

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 47.20  E-value: 3.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   4 ASVIIMDEHPIVRMSIEVLLgkNSN-IQVvlKTDDSrtAIEYLRTYPVDL---VILDIELPGTDGFTLLKRIKSIQEHTR 79
Cdd:cd17537    1 ATVYVVDDDEAVRDSLAFLL--RSVgLAV--KTFTS--ASAFLAAAPPDQpgcLVLDVRMPGMSGLELQDELLARGSNIP 74

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446723960  80 ILFLSSKSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVK 118
Cdd:cd17537   75 IIFITGHGDVPMAVEAMKAGAVDFLEKPFRDQVLLDAIE 113
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 37-106 4.06e-07

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 47.11  E-value: 4.06e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  37 DSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSSKSEAFYAGRAIRAGANGFVSK 106
Cdd:cd17550   30 DGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLPVIMISGHGTIETAVKATKLGAYDFIEK 99
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 6-88 5.26e-07

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 46.57  E-value: 5.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLGKNSNIqvVLKTDDSRTAIEYLRTYP-VDLVILDIELPG-TDGFTLLKRIKSIQEHTRILFL 83
Cdd:cd18161    1 VLVVEDDPDVRRLTAEVLEDLGYT--VLEAASGDEALDLLESGPdIDLLVTDVIMPGgMNGSQLAEEARRRRPDLKVLLT 78


                 ....*
gi 446723960  84 SSKSE 88
Cdd:cd18161   79 SGYAE 83
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
 6-106 6.94e-07

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 45.96  E-value: 6.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLGKNSniQVVLKTDDSRTAIEYLRT-YPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLS 84
Cdd:cd18160    2 ILLADDEPSVRKFIVTTLKKAG--YAVTEAESGAEALEKLQQgKDIDIVVTDIVMPEMDGIELAREARKIDPDVKILFIS 79

                         90       100
                 ....*....|....*....|..
gi 446723960  85 SKSEAFYAGRAIRAGANGFVSK 106
Cdd:cd18160   80 GGAAAAPELLSDAVGDNATLKK 101
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 29-106 1.78e-06

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 45.15  E-value: 1.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  29 IQVVLKTD--------DSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSiQEHTRILFLSSKSEAFYAGRAIRAGA 100
Cdd:cd17626   16 IGIVLRGEgfdpafcgDGTQALAAFREVRPDLVLLDLMLPGIDGIEVCRQIRA-ESGVPIVMLTAKSDTVDVVLGLESGA 94


                 ....*.
gi 446723960 101 NGFVSK 106
Cdd:cd17626   95 DDYVAK 100
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 7-121 2.06e-06

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 45.06  E-value: 2.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   7 IIMDEHPIVRMSIEVLLGKNSNIQVVlktDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEhTRILFLSSK 86
Cdd:cd19938    4 IVEDEPKLAQLLIDYLRAAGYAPTLL---AHGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCREIRRFSD-VPIIMVTAR 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 446723960  87 SEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMIL 121
Cdd:cd19938   80 VEEIDRLLGLELGADDYICKPYSPREVVARVKAIL 114
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 6-106 2.40e-06

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 45.07  E-value: 2.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLGKNSNIqvVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSS 85
Cdd:cd17627    1 ILVVDDDRAVRESLRRSLRFEGYE--VETAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGNDLPILVLTA 78

                         90       100
                 ....*....|....*....|.
gi 446723960  86 KSEAFYAGRAIRAGANGFVSK 106
Cdd:cd17627   79 RDSVSDRVAGLDAGADDYLVK 99
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 36-120 3.02e-06

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 44.57  E-value: 3.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  36 DDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSSKSEAFYAGRAIRAGANGFVSKRKDLNDiyn 115
Cdd:cd19919   31 ENAQEALAALASSQPDVLISDIRMPGMDGLALLAQIKQRHPDLPVIIMTAHSDLDSAVSAYQGGAFEYLPKPFDIDE--- 107


                 ....*
gi 446723960 116 AVKMI 120
Cdd:cd19919  108 AVALV 112
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 7-106 4.14e-06

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 44.46  E-value: 4.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   7 IIMDEHPI---VRMSIEVLLGKNsniqvVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSiQEHTR---I 80
Cdd:cd17552    6 VIDDEEDIrevVQACLEKLAGWE-----VLTASSGQEGLEKAATEQPDAILLDVMMPDMDGLATLKKLQA-NPETQsipV 79

                         90       100
                 ....*....|....*....|....*.
gi 446723960  81 LFLSSKSEAFYAGRAIRAGANGFVSK 106
Cdd:cd17552   80 ILLTAKAQPSDRQRFASLGVAGVIAK 105
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 6-106 4.26e-06

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 43.91  E-value: 4.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSI-EVLLGKNSNIQVVLKTDDsrtAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQE--HTRILF 82
Cdd:cd19927    1 ILLVDDDPGIRLAVkDYLEDQGFTVIAASNGLE---ALDLLNQYIPDLIISDIIMPGVDGYSLLGKLRKNADfdTIPVIF 77

                         90       100
                 ....*....|....*....|....
gi 446723960  83 LSSKSEAFYAGRAIRAGANGFVSK 106
Cdd:cd19927   78 LTAKGMTSDRIKGYNAGCDGYLSK 101
pleD PRK09581
response regulator PleD; Reviewed
 32-106 4.35e-06

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 46.43  E-value: 4.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  32 VLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRI-----LFLSSKSEAFyagRAIRAGANGFVSK 106
Cdd:PRK09581  29 VLTASSGAEAIAICEREQPDIILLDVMMPGMDGFEVCRRLKSDPATTHIpvvmvTALDDPEDRV---RGLEAGADDFLTK 105
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 6-106 5.42e-06

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 43.95  E-value: 5.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRmSIEVLLGKNSniQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQeHTRILFLSS 85
Cdd:cd17614    2 LVVDDEKPISD-ILKFNLTKEG--YEVVTAYDGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTS-NVPIIMLTA 77

                         90       100
                 ....*....|....*....|.
gi 446723960  86 KSEAFYAGRAIRAGANGFVSK 106
Cdd:cd17614   78 KDSEVDKVLGLELGADDYVTK 98
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 41-88 6.30e-06

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 45.34  E-value: 6.30e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 446723960  41 AIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSSKSE 88
Cdd:PRK11083  39 ALDKLRQQPPDLVILDVGLPDISGFELCRQLLAFHPALPVIFLTARSD 86
PRK10100 PRK10100
transcriptional regulator CsgD;
79-207 9.91e-06

transcriptional regulator CsgD;


Pssm-ID: 182241 [Multi-domain]  Cd Length: 216  Bit Score: 44.86  E-value: 9.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  79 RILFLSSKSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMILSGYSFFPSETLNFISntrTPKGGHH-----DMPLSNR 153
Cdd:PRK10100  83 KILLLNTPEDYPYREIENWPHINGVFYAMEDQERVVNGLQGVLRGECYFTQKLASYLI---THSGNYRynsteSALLTHR 159

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446723960 154 EVTVLRYLANGMSNKEIAEQLLLSNKTISAHKANIFSKLGLHSIVELIDYAKSH 207
Cdd:PRK10100 160 EKEILNKLRIGASNNEIARSLFISENTVKTHLYNLFKKIAVKNRTQAVSWANDN 213
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 5-106 1.04e-05

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 43.29  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   5 SVIIMDEHPIVRMSIEVLLGKNSNIQVVLKTDdSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLS 84
Cdd:cd17593    2 KVLICDDSSMARKQLARALPADWDVEITFAEN-GEEALEILREGRIDVLFLDLTMPVMDGYEVLEALPVEQLETKVIVVS 80

                         90       100
                 ....*....|....*....|....
gi 446723960  85 S--KSEAfyAGRAIRAGANGFVSK 106
Cdd:cd17593   81 GdvQPEA--KERVLELGALAFLKK 102
REC_typeA_ARR cd17581
phosphoacceptor receiver (REC) domain of type A Arabidopsis response regulators (ARRs) and ...
 6-113 1.20e-05

phosphoacceptor receiver (REC) domain of type A Arabidopsis response regulators (ARRs) and similar proteins; Type-A response regulators of Arabidopsis (ARRs) are involved in cytokinin signaling, which involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Type-A ARRs function downstream of and are regulated by type-B ARRs, which are a class of MYB-type transcription factors. As primary cytokinin response genes, type-A ARRs act as redundant negative feedback regulators of cytokinin signaling by inactivating the phosphorelay. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-A ARRs are similar in domain structure to CheY, in that they lack a typical output domain and only contain a stand-alone receiver (REC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381119 [Multi-domain]  Cd Length: 122  Bit Score: 43.12  E-value: 1.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLgKNSNIQVvlKTDDSRT-AIEYL-----------RTYPVDLVILDIELPGTDGFTLLKRIK- 72
Cdd:cd17581    1 VLAVDDSLVDRKVIERLL-RISSCRV--TAVDSGKrALEFLgledeedssnfNEPKVNMIITDYCMPGMTGYDLLKKVKe 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 446723960  73 -SIQEHTRILFLSSKSEAFYAGRAIRAGANGFVSKRKDLNDI 113
Cdd:cd17581   78 sSALKEIPVVIMSSENIPTRISRCLEEGAEDFLLKPVKLADV 119
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 6-106 1.36e-05

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 43.25  E-value: 1.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLGKnSNIQVVLkTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSS 85
Cdd:cd17549    1 VLLVDDDADVREALQQTLEL-AGFRVRA-FADAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIRELDPDLPVILITG 78

                         90       100
                 ....*....|....*....|.
gi 446723960  86 KSEAFYAGRAIRAGANGFVSK 106
Cdd:cd17549   79 HGDVPMAVEAMRAGAYDFLEK 99
REC_WspR-like cd17575
phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The ...
 4-109 1.54e-05

phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The GGDEF response regulator WspR is part of the Wsp system that is homologous to chemotaxis systems and also includes the membrane-bound receptor protein WspA. In response to growth on surfaces, WspR is phosphorylated by the Wsp signal transduction complex and is activated, functioning as a diguanylate cyclase (DGC) that catalyzes c-di-GMP synthesis. WspR is a hybrid response regulator-diguanylate cyclase, containing an N-terminal REC domain and a C-terminal GGDEF domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381117 [Multi-domain]  Cd Length: 128  Bit Score: 42.78  E-value: 1.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   4 ASVIIMDEHPIVRMSIEVLLGKNSNIQVVLKTDDSRTAIEYLRTYPVdlVIL-DIELPGTDGFTLLK--RIKSIQEHTRI 80
Cdd:cd17575    1 IMVLLVDDQAIIGEAVRRALADEEDIDFHYCSDPTEAIEVASQIKPT--VILqDLVMPGVDGLTLVRffRANPATRDIPI 78

                         90       100
                 ....*....|....*....|....*....
gi 446723960  81 LFLSSKSEAFYAGRAIRAGANGFVSKRKD 109
Cdd:cd17575   79 IVLSTKEEPEVKSEAFALGANDYLVKLPD 107
PLN03029 PLN03029
type-a response regulator protein; Provisional
 6-113 1.74e-05

type-a response regulator protein; Provisional


Pssm-ID: 215544 [Multi-domain]  Cd Length: 222  Bit Score: 44.25  E-value: 1.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLgKNSNIQVVlKTDDSRTAIEYL------RTYP--------------VDLVILDIELPGTDGF 65
Cdd:PLN03029  11 VLAVDDSLIDRKLIEKLL-KTSSYQVT-TVDSGSKALKFLglheddRSNPdtpsvspnshqeveVNLIITDYCMPGMTGY 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 446723960  66 TLLKRIK--SIQEHTRILFLSSKSEAFYAGRAIRAGANGFVSKRKDLNDI 113
Cdd:PLN03029  89 DLLKKIKesSSLRNIPVVIMSSENVPSRITRCLEEGAEEFFLKPVQLSDL 138
REC_RcNtrC-like cd19928
phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C ...
 51-106 2.36e-05

phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C (NtrC) and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include NtrC, also called nitrogen regulator I (NRI), from Rhodobacter capsulatus, Azospirillum brasilense, and Azorhizobium caulinodans. NtrC is part of the NtrB/NtrC two-component system that controls the expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381155 [Multi-domain]  Cd Length: 100  Bit Score: 41.72  E-value: 2.36e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446723960  51 DLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSSKSEAFYAGRAIRAGANGFVSK 106
Cdd:cd19928   44 DLVITDVVMPDENGLDLIPRIKKARPDLPIIVMSAQNTLMTAVKAAERGAFEYLPK 99
PRK04841 PRK04841
HTH-type transcriptional regulator MalT;
149-206 3.06e-05

HTH-type transcriptional regulator MalT;


Pssm-ID: 235315 [Multi-domain]  Cd Length: 903  Bit Score: 44.16  E-value: 3.06e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446723960 149 PLSNREVTVLRYLANGMSNKEIAEQLLLSNKTISAHKANIFSKLGLHSIVELIDYAKS 206
Cdd:PRK04841 838 PLTQREWQVLGLIYSGYSNEQIAGELDVAATTIKTHIRNLYQKLGIAHRQEAVQHAQD 895
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 6-115 3.33e-05

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 41.84  E-value: 3.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLGKnSNIQVVlKTDDSRTAIEYLRTYP--VDLVILDIELPGTDGFTLLKRIKSIQEhTRILFL 83
Cdd:cd17584    1 VLVVDDDPTCLAILKRMLLR-CGYQVT-TCTDAEEALSMLRENKdeFDLVITDVHMPDMDGFEFLELIRLEMD-LPVIMM 77

                         90       100       110
                 ....*....|....*....|....*....|..
gi 446723960  84 SSKSEAFYAGRAIRAGANGFVSKRKDLNDIYN 115
Cdd:cd17584   78 SADGSTSTVMKGLAHGACDYLLKPVSIEDLKN 109
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 37-88 4.03e-05

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 41.32  E-value: 4.03e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446723960  37 DSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSSKSE 88
Cdd:cd17624   30 TGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQGQSLPVLILTARDG 81
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 40-106 4.50e-05

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 41.21  E-value: 4.50e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446723960  40 TAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSiQEHTRILFLSSKSEAFYAGRAIRAGANGFVSK 106
Cdd:cd17622   35 RALEVIAREKPDAVLLDIMLPGIDGLTLCRDLRP-KYQGPILLLTALDSDIDHILGLELGADDYVVK 100
PRK10766 PRK10766
two-component system response regulator TorR;
5-121 5.36e-05

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 42.72  E-value: 5.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   5 SVIIMDEHPIVRMSIEVLLGKNSniQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSiQEHTRILFLS 84
Cdd:PRK10766   4 HILVVEDEPVTRARLQGYFEQEG--YTVSEAASGAGMREIMQNQHVDLILLDINLPGEDGLMLTRELRS-RSTVGIILVT 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446723960  85 SKSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMIL 121
Cdd:PRK10766  81 GRTDSIDRIVGLEMGADDYVTKPLELRELLVRVKNLL 117
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 1-88 5.70e-05

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 42.75  E-value: 5.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   1 MKPASVIIMDEHPIVRMSIEVLLGKNSNIQVVLKTDDsrtAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEhTRI 80
Cdd:PRK10710   9 NTPRILIVEDEPKLGQLLIDYLQAASYATTLLSHGDE---VLPYVRQTPPDLILLDLMLPGTDGLTLCREIRRFSD-IPI 84


                 ....*...
gi 446723960  81 LFLSSKSE 88
Cdd:PRK10710  85 VMVTAKIE 92
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 6-123 5.78e-05

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 41.16  E-value: 5.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLGKNsNIQVVLkTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQE--HTRILFL 83
Cdd:cd17598    1 ILIVEDSPTQAEQLKHILEEQ-GYKVQV-ARNGREALAMLAEHRPTLVISDIVMPEMDGYELCRKIKSDPDlkDIPVILL 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 446723960  84 SSKSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMILSG 123
Cdd:cd17598   79 TTLSDPRDVIRGLECGADNFITKPYDEKYLLSRIKYILVN 118
PRK15479 PRK15479
transcriptional regulator TctD;
37-113 6.29e-05

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 42.40  E-value: 6.29e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446723960  37 DSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSSKSEAFYAGRAIRAGANGFVSKRKDLNDI 113
Cdd:PRK15479  32 DGLAADHLLQSEMYALAVLDINMPGMDGLEVLQRLRKRGQTLPVLLLTARSAVADRVKGLNVGADDYLPKPFELEEL 108
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
6-121 6.49e-05

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 42.40  E-value: 6.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLlgKNSNIQVVlKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIK--SIQEHTRILFL 83
Cdd:PRK10161   6 LVVEDEAPIREMVCFVL--EQNGFQPV-EAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKreSMTRDIPVVML 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446723960  84 SSKSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMIL 121
Cdd:PRK10161  83 TARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVM 120
PRK10610 PRK10610
chemotaxis protein CheY;
7-119 1.00e-04

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 40.73  E-value: 1.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   7 IIMDEHPIVRMSIEVLLgKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFL--- 83
Cdd:PRK10610   9 LVVDDFSTMRRIVRNLL-KELGFNNVEEAEDGVDALNKLQAGGFGFVISDWNMPNMDGLELLKTIRADGAMSALPVLmvt 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 446723960  84 -SSKSEAFYAgrAIRAGANGFVSK-------RKDLNDIYNAVKM 119
Cdd:PRK10610  88 aEAKKENIIA--AAQAGASGYVVKpftaatlEEKLNKIFEKLGM 129
PRK10336 PRK10336
two-component system response regulator QseB;
37-106 1.07e-04

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 41.80  E-value: 1.07e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  37 DSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSSKSEAFYAGRAIRAGANGFVSK 106
Cdd:PRK10336  32 QGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTARDALAERVEGLRLGADDYLCK 101
PRK10816 PRK10816
two-component system response regulator PhoP;
6-106 1.27e-04

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 41.65  E-value: 1.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLgkNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSS 85
Cdd:PRK10816   3 VLVVEDNALLRHHLKVQL--QDAGHQVDAAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDVSLPILVLTA 80

                         90       100
                 ....*....|....*....|.
gi 446723960  86 KSEAFYAGRAIRAGANGFVSK 106
Cdd:PRK10816  81 RESWQDKVEVLSAGADDYVTK 101
REC_HP-RR-like cd17573
phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; ...
 43-111 1.77e-04

phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; Helicobacter pylori response regulator hp1043 (HP-RR) is an orphan response regulator which is phosphorylation-independent and is essential for growth. HP-RR functions as a cell growth-associated regulator in the absence of post-translational modification. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381115 [Multi-domain]  Cd Length: 110  Bit Score: 39.72  E-value: 1.77e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446723960  43 EYL---RTYpvDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSSKSEAFYAGRAIRAGANGFVSKRKDLN 111
Cdd:cd17573   35 EYYidiRNY--DLVLVSDKLPDGNGLSIVSRIKEKHPSIVVIVLSDNPKTEQEIEAFKEGADDYIAKPFDFK 104
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
39-122 1.80e-04

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 41.55  E-value: 1.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  39 RTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSSKSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVK 118
Cdd:PRK10365  39 RQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVLIMTAYSSVETAVEALKTGALDYLIKPLDFDNLQATLE 118


                 ....
gi 446723960 119 MILS 122
Cdd:PRK10365 119 KALA 122
orf27 CHL00148
Ycf27; Reviewed
 6-106 1.85e-04

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 41.24  E-value: 1.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEV---LLGKNsniqvVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSiQEHTRILF 82
Cdd:CHL00148   9 ILVVDDEAYIRKILETrlsIIGYE-----VITASDGEEALKLFRKEQPDLVILDVMMPKLDGYGVCQEIRK-ESDVPIIM 82

                         90       100
                 ....*....|....*....|....
gi 446723960  83 LSSKSEAFYAGRAIRAGANGFVSK 106
Cdd:CHL00148  83 LTALGDVSDRITGLELGADDYVVK 106
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 1-124 2.64e-04

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 41.01  E-value: 2.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   1 MKPASVIIMDEHPIVRMSIEVLLgknSNIQVVLKT-DDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTR 79
Cdd:PRK10923   1 MQRGIVWVVDDDSSIRWVLERAL---AGAGLTCTTfENGNEVLEALASKTPDVLLSDIRMPGMDGLALLKQIKQRHPMLP 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 446723960  80 ILFLSSKSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMILSGY 124
Cdd:PRK10923  78 VIIMTAHSDLDAAVSAYQQGAFDYLPKPFDIDEAVALVERAISHY 122
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 6-106 3.51e-04

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 38.67  E-value: 3.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLGKNS-NIQVVLKTDDSRtaiEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLS 84
Cdd:cd19926    1 VLVVDDEPDIRELLEITLGRMGlDVRSARNVKEAR---ELLASEPYDLCLTDMRLPDGSGLELVQHIQQRLPQTPVAVIT 77

                         90       100
                 ....*....|....*....|..
gi 446723960  85 SKSEAFYAGRAIRAGANGFVSK 106
Cdd:cd19926   78 AYGSLDTAIEALKAGAFDFLTK 99
PRK14084 PRK14084
DNA-binding response regulator;
6-82 5.65e-04

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 39.73  E-value: 5.65e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446723960   6 VIIMDEHPIVRMSIEVLLGKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILF 82
Cdd:PRK14084   3 ALIVDDEPLARNELTYLLNEIGGFEEINEAENVKETLEALLINQYDIIFLDINLMDESGIELAAKIQKMKEPPAIIF 79
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
5-101 8.17e-04

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 39.72  E-value: 8.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960    5 SVIIMDEHPIVRMsievLLGKNSNI--QVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILF 82
Cdd:PRK09959  960 SILIADDHPTNRL----LLKRQLNLlgYDVDEATDGVQALHKVSMQHYDLLITDVNMPNMDGFELTRKLREQNSSLPIWG 1035

                          90
                  ....*....|....*....
gi 446723960   83 LSSKSEAFYAGRAIRAGAN 101
Cdd:PRK09959 1036 LTANAQANEREKGLSCGMN 1054
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 37-88 1.29e-03

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 37.28  E-value: 1.29e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446723960  37 DSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEhTRILFLSSKSE 88
Cdd:cd17623   30 DGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELRKTSQ-VPVLMLTARGD 80
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 6-106 1.60e-03

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 36.82  E-value: 1.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLgKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTR--ILFL 83
Cdd:cd17561    5 LIADDNREFVQLLEEYLN-SQPDMEVVGVAHNGQEALELIEEKEPDVLLLDIIMPHLDGIGVLEKLRRMRLEKRpkIIML 83

                         90       100
                 ....*....|....*....|...
gi 446723960  84 SSKSEAFYAGRAIRAGANGFVSK 106
Cdd:cd17561   84 TAFGQEDITQRAVELGASYYILK 106
PRK15115 PRK15115
response regulator GlrR; Provisional
 2-117 1.68e-03

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 38.66  E-value: 1.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   2 KPASVIIMDEHPivrmSIEVLLGK--NSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTR 79
Cdd:PRK15115   4 KPAHLLLVDDDP----GLLKLLGMrlTSEGYSVVTAESGQEALRVLNREKVDLVISDLRMDEMDGMQLFAEIQKVQPGMP 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446723960  80 ILFLSSKSEAFYAGRAIRAGANGFVSKRKDLNDIYNAV 117
Cdd:PRK15115  80 VIILTAHGSIPDAVAATQQGVFSFLTKPVDRDALYKAI 117
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 30-80 2.24e-03

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 38.29  E-value: 2.24e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446723960  30 QVVLkTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIK--SIQEHTRI 80
Cdd:PRK11107 693 HVVL-CDSGHQAVEQAKQRPFDLILMDIQMPGMDGIRACELIRqlPHNQNTPI 744
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
6-125 2.36e-03

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 38.42  E-value: 2.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLGKnsnIQVVLKT-DDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLS 84
Cdd:PRK10841 804 ILVVDDHPINRRLLADQLGS---LGYQCKTaNDGVDALNVLSKNHIDIVLTDVNMPNMDGYRLTQRLRQLGLTLPVIGVT 880

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 446723960  85 SKSEAFYAGRAIRAGANGFVSKRKDLNDIynavKMILSGYS 125
Cdd:PRK10841 881 ANALAEEKQRCLEAGMDSCLSKPVTLDVL----KQTLTVYA 917
ompR PRK09468
osmolarity response regulator; Provisional
 50-88 2.51e-03

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 37.65  E-value: 2.51e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 446723960  50 VDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSSKSE 88
Cdd:PRK09468  50 FHLMVLDLMLPGEDGLSICRRLRSQNNPTPIIMLTAKGE 88
PRK10701 PRK10701
DNA-binding transcriptional regulator RstA; Provisional
 19-67 2.70e-03

DNA-binding transcriptional regulator RstA; Provisional


Pssm-ID: 236738 [Multi-domain]  Cd Length: 240  Bit Score: 37.69  E-value: 2.70e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 446723960  19 IEVLLGKNsNIQVVLKTDDSRTAIEYLRTYPvDLVILDIELPGTDGFTL 67
Cdd:PRK10701  17 IAAYLAKH-DIDVTVEPRGDRAEATILREQP-DLVLLDIMLPGKDGMTI 63
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 5-106 5.22e-03

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 35.68  E-value: 5.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   5 SVIIMDEHPIVRMSIEVLL-------GKNSNIQVVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEH 77
Cdd:cd17533    2 NIFILEDDKIQRVRLEEIIenilkieNIEYVIELTGKTEELLEKIKERGKNGIYFLDIDIKMEEKNGLEVAQKIRKYDPY 81

                         90       100
                 ....*....|....*....|....*....
gi 446723960  78 TRILFLSSKSEAFYAGRAIRAGANGFVSK 106
Cdd:cd17533   82 AIIIFVTTHSEFAPLTFEYKVAALDFILK 110
psREC_PRR cd17582
pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response ...
 6-106 6.40e-03

pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response regulators (PRRs), also called APRRs, comprise a core group of clock components that controls the pace of the central oscillator of the circadian clock, an endogenous time-keeping mechanism that enables organisms to adapt to external daily cycles. The coordinated sequential expression of PRR9 (APRR9), PRR7 (APRR7), PRR5 (APRR5), PRR3 (APRR3), and PRR1 (APRR1) results in circadian waves that may be at the basis of the endogenous circadian clock. PRRs contain an N-terminal pseudo receiver (psREC) domain that resembles the receiver domain of a two-component response regulator, but lacks an aspartate residue that accepts a phosphoryl group from the sensor kinase, and a CCT motif at the C-terminus that contains a putative nuclear localization signal. The psREC domain is involved in protein-protein interactions.


Pssm-ID: 381120 [Multi-domain]  Cd Length: 104  Bit Score: 35.07  E-value: 6.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLgKNSNIQVVlKTDDSRTAIEYLRTYP--VDLVILDIELPGTDGFTLLKRIKS--IQEHTRIL 81
Cdd:cd17582    1 VLLVENDDSTRQIVTALL-RKCSYEVT-AASDGLQAWDVLEDEQneIDLILTEVDLPVSSGFKLLSYIMRhkICKNIPVI 78

                         90       100
                 ....*....|....*....|....*
gi 446723960  82 FLSSKSEAFYAGRAIRAGANGFVSK 106
Cdd:cd17582   79 MMSSQDSVGVVFKCLSKGAADYLVK 103
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
 5-72 8.40e-03

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 35.42  E-value: 8.40e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446723960   5 SVIIMDEHPIVRMSIEVLLGKNSNiqvVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIK 72
Cdd:cd17596    2 TILVVDDEVRSLEALRRTLEEDFD---VLTAASAEEALAILEEEWVQVILCDQRMPGTTGVEFLKEVR 66
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 41-118 8.45e-03

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 34.87  E-value: 8.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  41 AIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSSKSEAFYAGRAIRAGANGFVSK---RKDLN-DIYNA 116
Cdd:cd17572   34 ALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVITAHGSVDIAVEAMRLGAYDFLEKpfdADRLRvTVRNA 113


                 ..
gi 446723960 117 VK 118
Cdd:cd17572  114 LK 115
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 31-161 9.12e-03

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 36.06  E-value: 9.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  31 VVLKTDDSRTAIEYLRTYPVDLVILDIELPGTDGFTLLKRIKSIQEHTRILFLSSKSEAFYAGRAIRAGANGFVSKRKDL 110
Cdd:PRK09836  26 VVDLADNGLNGYHLAMTGDYDLIILDIMLPDVNGWDIVRMLRSANKGMPILLLTALGTIEHRVKGLELGADDYLVKPFAF 105

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446723960 111 NDIYNAVKMIL-SGYSFFPSE-------TLNFISNTRTPKGGHhdMPLSNREVTVLRYL 161
Cdd:PRK09836 106 AELLARVRTLLrRGAAVIIESqfqvadlMVDLVSRKVTRSGTR--ITLTSKEFTLLEFF 162
Sig70_bacteroi1 TIGR02985
RNA polymerase sigma-70 factor, Bacteroides expansion family 1; This group of sigma factors ...
 148-187 9.38e-03

RNA polymerase sigma-70 factor, Bacteroides expansion family 1; This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.


Pssm-ID: 274376 [Multi-domain]  Cd Length: 161  Bit Score: 35.62  E-value: 9.38e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 446723960  148 MPLSNREVTVLRYLaNGMSNKEIAEQLLLSNKTISAHKAN 187
Cdd:TIGR02985 114 LPEQCREIFILSRF-EGLSNKEIAEELGISVKTVEYHITK 152
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 6-177 9.66e-03

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 35.94  E-value: 9.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960   6 VIIMDEHPIVRMSIEVLLGKNsnIQVVLKTDDSRTAIEYLRTYPvDLVILDIELPGTDGFTLLKRIKSIQEhTRILFLSS 85
Cdd:PRK10529   5 LIVEDEQAIRRFLRTALEGDG--MRVFEAETLQRGLLEAATRKP-DLIILDLGLPDGDGIEFIRDLRQWSA-IPVIVLSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446723960  86 KSEAFYAGRAIRAGANGFVSKRKDLNDIYNAVKMILSGYSFFPSET--LNF------ISNTRTPKGGH--HDMPLSNREV 155
Cdd:PRK10529  81 RSEESDKIAALDAGADDYLSKPFGIGELQARLRVALRRHSATPAPDplVKFsdvtvdLAARVIHRGEEevHLTPIEFRLL 160

                        170       180
                 ....*....|....*....|..
gi 446723960 156 TVLryLANgmSNKEIAEQLLLS 177
Cdd:PRK10529 161 AVL--LNN--AGKVLTQRQLLN 178
PRK11517 PRK11517
DNA-binding response regulator HprR;
52-106 9.67e-03

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 36.03  E-value: 9.67e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446723960  52 LVILDIELPGTDGFTLLKRIKSIQEhTRILFLSSKSEAFYAGRAIRAGANGFVSK 106
Cdd:PRK11517  47 LIILDIMLPGMDGWQILQTLRTAKQ-TPVICLTARDSVDDRVRGLDSGANDYLVK 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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