|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
8-390 |
4.91e-161 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 457.58 E-value: 4.91e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 8 TAVGLYFNYFVHGMGVILMSLNMSSLEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFI 87
Cdd:cd17396 1 TALGLYFNYFVHGMGVIILAQNMSSLSEKWHTDVAGVAYVISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALFFV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 88 GILYAQTIFVAYACGFLAGMANSFLDAGTYPSLMEAFPRSPSTANILIKAFVSGGQFLLPIIISLLVWANMWFGWSFLLA 167
Cdd:cd17396 81 GILFSPNLIIAYVFALLAGAANSFLDTGTYPALMEAFPKASGSANILVKAFVSFGQFLLPFIIAFLAANNLWYGWSFIVP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 168 GAIMLINALFLLRCPFPPYPGRILKPKISQAPVTGVHHCSLIDLISYTLYGYISMATFYLISQWLAQYGQFVAGMSYTQS 247
Cdd:cd17396 161 AAVLVLNALLLLKLSFPPQTVTAANTKQKEIPVKREKPKFLIEGIALILIGFTSTATFYLFSQWMPKYGSAVAGMGEAES 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 248 IKLLSIYTCGSLLCVFITAPLVRKTIRSTTLLMFYTFISFIALLTVCLHPQAYVVMIFAFVIGFSSAGGVVQIGLTLMAA 327
Cdd:cd17396 241 LKLISYYSMGSLVCVFITAVLLKRYVRPIWILVLYPIISLLALFVLYLVPSPDVCILGAFVIGFFAAGGVLQLGLTLMAE 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446720356 328 RFPQEKGKATGIYYSAGSIATFTIPLITARI-SEMSIAHIMWFDTGIAAAGFLLALFIGYRSRA 390
Cdd:cd17396 321 FFPKGKGKVTGIYMIASSLANFVIPLITGIIaSAIGIAYIFLFDFGIALLGLLLAIFVFIRYRK 384
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
12-383 |
2.92e-65 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 212.57 E-value: 2.92e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 12 LYFNYFVHGMGVILMSLNMSSLEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILY 91
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 92 AQTIFVAYACGFLAGMANSFLDAGTYPSLMEAFPRSPSTANILIKAFVSGGQFLLPIIISLLVWANMWFGWSFLLAGAIM 171
Cdd:cd17333 81 TPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 172 LINALFLLRCPFPPYPGRILKPKISQAPVTGV----HHCSLIDLISYTLYGYISMATFYLISQWLAQYGQfvaGMSYTQS 247
Cdd:cd17333 161 LLLAILILLTLFPELPSARNPQQSVGAFSASAsrllRNPSIILGALALFLYVGAETAFSSWVPSYLVEKK---HVSDGLA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 248 IKLLSIYTCGSLLCVFITAPLVRKtIRSTTLLMFYTFISFIALLTVCLHPqAYVVMIFAFVIGFSSAGGVVQIGLTLMAA 327
Cdd:cd17333 238 GYLLSGFWVGITIGRLLGGPISRR-IKPHTLLVLSGSGALLGLLILLLAP-TLVVGLVATALLGLFMAALFPTILSLGIS 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 446720356 328 RFPQEKGKATGIYYSAGSIATFTIPLITARI-SEMSIAHIMWFDTGIAAAGFLLALF 383
Cdd:cd17333 316 NLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIaEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
2-391 |
5.10e-26 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 108.02 E-value: 5.10e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 2 KNRYFPTAVGLYFNYFVHGMGVILMSLNMSSLEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTAC 81
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 82 YLIFFIGILYAQTIFVAYACGFLAGMANSFLDAGTYPSLMEAFPRSPSTANILIKAFVSGGQFLLPIIISLLVWANMWFG 161
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 162 W--SFLLAGAIMLINALFLLRCPFPPYPGRILKPKISQAPVTGVHHCSLIDLISYTLYGYisMATFYLISQWLAQYGQFV 239
Cdd:COG0738 163 WhlPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLY--VGAEGAIGDWLPLYLKDV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 240 AGMSYTQSIKLLSIYTCGSLLCVFITAPLVRKtIRSTTLLMFYTFISFIALLTVCLHPQAYVVMIFAFVIGFSSAgGVVQ 319
Cdd:COG0738 241 LGLSEATAALGLSLFWGGMTIGRFLGGFLLKR-FGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLS-LMFP 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446720356 320 IGLTLMAARFPQEKGKATGIYYSAGSIATFTIPLITARISE-MSIAHIMWFDTGIAAAGFLLALFIGYRSRAE 391
Cdd:COG0738 319 TIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADaFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
8-347 |
4.53e-20 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 90.42 E-value: 4.53e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 8 TAVGLYFNYFVHGMGVILMSLNMSSLEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFI 87
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 88 GILYAQTIFVAYACGFLAGMANSFLDAGTYPSLMEAFPRS-PSTANILIKAFVSGGQFLLPIIISLLVwANMWFGWSFLL 166
Cdd:COG2814 91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPErRGRALGLLGAGLGLGPALGPLLGGLLA-DLFGWRWVFLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 167 AGAIMLINALFLLRcpFPPYPGRILKPKISQAPVTGVHHCSlidLISYTLYGYISMATFYLISQWLAQYGQFVAGMSYTQ 246
Cdd:COG2814 170 NAVLALLALLLLLR--LLPESRPAARARLRGSLRELLRRPR---LLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 247 SIKLLSIYTCGSLLCVFITAPLVRKtIRSTTLLMFYTFISFIALLTVCLHPQAYVVMIFAFVIGFSSAGGVVQIGLTLMA 326
Cdd:COG2814 245 AGLLLALFGLGGVLGALLAGRLADR-FGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAE 323
|
330 340
....*....|....*....|.
gi 446720356 327 ARFPQEKGKATGIYYSAGSIA 347
Cdd:COG2814 324 LAPPEARGRASGLYNSAFFLG 344
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
14-394 |
1.15e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 86.86 E-value: 1.15e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 14 FNYFVHGMGVILMSLNMSSLEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILYAQ 93
Cdd:COG2223 12 LAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 94 TIFVAYACGFLAGMANSFLDAGTYPSLMEAFP-RSPSTANILIKAFVSGGQFLLPIIISLLVwanMWFGWS--FLLAGAI 170
Cdd:COG2223 92 SYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPpDRRGLALGLAAGGGNLGAAVAAFLAPLLI---AAFGWRnaFLILGIL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 171 MLINALFLLRCPFPPYPGRILKPKISQAPVTGVhhCSLIDLISYTLYGYISMATFYLISQWLAQYGQFVAGMSYTQSIKL 250
Cdd:COG2223 169 LLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEA--LRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 251 LSIYTCGSLLCVFITAPLVRKTIRSTTLLMFYTFISFIALLTVCLHPQAYVVMIFAFVIGFSSAGGVVqIGLTLMAARFP 330
Cdd:COG2223 247 AALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNG-AVFALVPDIFP 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446720356 331 QEK-GKATGIYYSAGSIATFTIPLITARISEM--SIAHIMWFDTGIAAAGFLLALFIGYRSRAESQH 394
Cdd:COG2223 326 TKNaGAVYGLVGAAGGLGGFLGPLLFGALLDAtgSYTAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
10-389 |
1.75e-17 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 83.00 E-value: 1.75e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 10 VGLYFNYFVHGMGVILMSLNMSSLEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGI 89
Cdd:COG2271 13 ALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 90 LYAQTIFVAYACGFLAGMANSFLDAGTYPSLMEAFPRS-PSTANILIKAFVSGGQFLLPIIISLLVwANMWFGWSFLLAG 168
Cdd:COG2271 93 GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKeRGRALGIFNAGGPLGGALAPPLLGWLL-AAFGWRAAFLILG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 169 AIMLINAlfllrcpfppypgrilkpkisqapvtgvhhcsLIDLISYTLYGYISMATFYLISQWLAQYGQFVAGMSYTQSI 248
Cdd:COG2271 172 LPGLLLA--------------------------------LLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAG 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 249 KLLSIYTCGSLLCVFITAPLVRKTIRST-TLLMFYTFISFIALLTVCLHPQAYVVMIFAFVIGFSSAGGVVQIGlTLMAA 327
Cdd:COG2271 220 LLLSLPFLAGIVGSLLGGWLSDRLGRRRkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLW-ALAAE 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446720356 328 RFPQEK-GKATGIYYSAGSIATFTIPLITARISEM-SIAHIMWFDTGIAAAGFLLALFIGYRSR 389
Cdd:COG2271 299 LFPKKArGTASGLVNTFGFLGGALGPLLVGYLLDAtGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
12-352 |
1.63e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 80.15 E-value: 1.63e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 12 LYFNYFVHGMGVILMSLNMSS-LEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGIL 90
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 91 YAQTIFVAYACGFLAGMANSFLDAGTYPSLMEAFPRS-PSTANILIKAFVSGGQFLLPIIISLLVWANMWfGWSFLLAGA 169
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEeRGRALGLVSAGFGLGAALGPLLGGLLASLFGW-RAAFLILAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 170 IMLINAL-FLLRCPFPPYPGRILKPKISQAPVTGVHHCSLIDLISYTLYGYISMATFYLISQWLAQYgQFVAGMSYTQSI 248
Cdd:pfam07690 160 LSLLAAVlLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 249 KLLSIYTCGSLLCVFITAPLVRKTIRSTTLLMFYTFISFIALLTVCLHPQAYVVMIFAFVIGFSSAGGVVQIGLTLMAAR 328
Cdd:pfam07690 239 LLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSD 318
|
330 340
....*....|....*....|....*.
gi 446720356 329 F--PQEKGKATGIYYSAGSIATFTIP 352
Cdd:pfam07690 319 LapKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
12-356 |
3.24e-14 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 73.61 E-value: 3.24e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 12 LYFNYFVHGMGVILMSLNMSSLEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILY 91
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 92 AQTIFVAYACGFLAGMANSFLDAGTYPSLMEAFPRSPSTANILIKAFVSGGQFLLPIIISLLVWANMWFGW-SFLLAGAI 170
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWrAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 171 MLINALFLLRCPFPPYPGRILKPKISQAPVTGVHHCSLIDLISYTLYGYIS----MATFYLISQWLAQYGQFVAGMSYTQ 246
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAiflvNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 247 SIKLLSIYTCGSLLCVFITAPLVRKTIRSTTLLMFYTFISFIALLTVCLHPQAYVVMIFAFVIGFSSAGGVVQIGLTLMA 326
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350
....*....|....*....|....*....|
gi 446720356 327 ARFPQEKGKATGIYYSAGSIATFTIPLITA 356
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAG 350
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
12-384 |
1.13e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 68.76 E-value: 1.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 12 LYFNYFVHGMGVILMSLNMSSLEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILY 91
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 92 AQTIFVAYACGFLAGMANSFLDAGTYPSLMEAFP-RSPSTANILIKAFVSGGQFLLPIIISLLVWANMwFGWSFLLAGAI 170
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPpEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 171 MLINALFLLRCPFPPYPGRILKPKISQAPVTGVHHCSL-IDLISYTLYGYISMATFYLISQWLAQYGQFVAGMSYTQSIK 249
Cdd:cd17325 160 ALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRdRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 250 LLSIYTCGSLLCVFITAPLVRKtIRSTTLLMFYTFISFIALLTVCLHPQAYVVMIFAFVIGFSSaGGVVQIGLTLMAARF 329
Cdd:cd17325 240 LFGAQGLASALSQPPAGKLSDR-IGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGL-GLVFPATLALLADIV 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 446720356 330 PQEK-GKATGIYYSAGSIATFTIPLITARISE-MSIAHIMWFDTGIAAAGFLLALFI 384
Cdd:cd17325 318 PPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYDaFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
8-288 |
4.13e-12 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 66.37 E-value: 4.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 8 TAVGLYFNYFVHGMGVILMSLNMSSLEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFI 87
Cdd:COG0477 15 ALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 88 GILYAQTIFVAYACGFLAGMANSFLDAGTYPSLMEAFPRSPSTANILIKAFVSGGQFLLPIIISLLVWANMWFGWSFLLA 167
Cdd:COG0477 95 LCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLIN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 168 GAIMLINALFLLRCPFPPYPGRILKPKISQAPVTGVHHCSLIDLISYTLYGYISMATFYLISQWLAQYGQFVAGMSYTQS 247
Cdd:COG0477 175 APLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLL 254
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 446720356 248 IKLLSIYTCGSLLCVFITAPLVRKTIRSTTLLMFYTFISFI 288
Cdd:COG0477 255 ALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
1-385 |
6.96e-11 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 63.35 E-value: 6.96e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 1 MKNRYFPTAVGLYFNYFVHGMGVILMSLNM-----------SSLEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRF 69
Cdd:COG2807 1 MSTTSSSARRSRRAGRWLLLLAIVLVALNLrpaitsvgpllPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 70 GRRPFIILGTACYLIFFIGILYAQTIFVAYACGFLAGMANSFLDAGTYPSLMEAFPRSPSTANILIKAFVSGGQFLLPii 149
Cdd:COG2807 81 GLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAA-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 150 iSLLVWANMWFGWSFLLAGAIMLINALFLLRCPFPPYPGRILKPKISQAPVTGVHHCSLIDLIsyTLYGYISMATFYLIS 229
Cdd:COG2807 159 -GLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLL--TLFFGLQSLLYYAVV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 230 QWLAQYGQfVAGMSYTQSIKLLSIYTCGSLLCVFITAPLVRKTIRSTTLLMFYTFISFIALLTVCLHPQAyVVMIFAFVI 309
Cdd:COG2807 236 AWLPPILR-DAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGS-LPWLWAVLL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 310 GFsSAGGVVQIGLTLMAARF--PQEKGKATGIYYSAGSIATFTIPLITARISEM--SIAHIMWFDTGIAAAGFLLALFIG 385
Cdd:COG2807 314 GL-GQGGLFPLALTLIGLRArtPAEAAALSGMAQSVGYLLAALGPLLVGALHDAtgSWTAALLLLAALAVLMLVAGLLAG 392
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
1-399 |
3.45e-09 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 58.01 E-value: 3.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 1 MKNRYFPTAVGlYFNYFVHGMGVILMSLNMSSLEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTA 80
Cdd:PRK03699 2 NSNRIKLTWIS-FLSYALTGALVIVTGMVMGPIAEYFNLPVSSMSNTFTFLNAGILISIFLNAWLMEIIPLKRQLIFGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 81 CYLIFFIGILYAQTIFVAYACGFLAGMANS-FLDAGTYPSLMEAFPRSPSTANILIKAFVSGGQFLLPIIISLLVWANMW 159
Cdd:PRK03699 81 LMILAVAGLMFSHSLALFSIAMFVLGVVSGiTMSIGTFLITHVYEGKQRGSRLLFTDSFFSMAGMIFPIIAAYLLARSIE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 160 FGWSFLLAGAIMLINALFLLRCPFPpypgrILKPKISQAPVTGVHHCSLIDLISYTLYGYISMATFYLISQWLAQYGQFV 239
Cdd:PRK03699 161 WYWVYACIGLVYVAIFILTLFSEFP-----ALGKHAPKADKPVAKEKWGIGVLFLAIAALLYILAQLTFISWVPEYAQKK 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 240 AGMSYTQSIKLLSIYTCGSLLCVFITAPLVRKtIRSTTLLMFYTFISFIALLTVCLHPQAYVVMIFAFVIGFSSAgGVVQ 319
Cdd:PRK03699 236 FGMSLEDAGNLVSNFWMAYMVGMWIFSFIVRF-FDLQRILTVLAGLALVLMYLFVNTDDPSHLLYAILGLGFFSS-AIYT 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 320 IGLTLMAARFPQEKGKATGIYYSAGSIATFTIPLITARISEMSIAH-IMWFDTGIAAAGFLLALFIGYRSRAESQHHAEA 398
Cdd:PRK03699 314 TIITLGSQQTKVASPKLVNFILTCGTIGTMLTFVVTSPIVAHFGLQaALLTANGLYAVVFVMCILLGFVSKHRQHGALTA 393
|
.
gi 446720356 399 A 399
Cdd:PRK03699 394 H 394
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
10-384 |
3.73e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 57.97 E-value: 3.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 10 VGLYFNYFVHGMGVILMSLNMSSLEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGI 89
Cdd:cd17474 2 YAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 90 LYAQTIFVAYACGFLAGMANSFLDAGTYPSLMEAFP-RSPSTANILIKAFVSGGQFLLPIIISLLvwANMWFGWSFLLAG 168
Cdd:cd17474 82 GLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEgGERAKAMGLYEAALGLGIAVGPLLGGLL--AAISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 169 AIMLINALFLLRcpFPPYPGRILKPKISQAPVTGVHHCSLIDLISYTLYGYISMATFYLISQWLAQYGQFVAGMSYTQSI 248
Cdd:cd17474 160 ALIPVAFLAILF--LLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 249 KLLSIYTCGSLLCVFITAPLVRKTIRSTTLLMFYTFISFIALLTVCLHPQAYVVMIFAFVIGFSSAGGVVQIGLTLMAAR 328
Cdd:cd17474 238 LLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELA 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 446720356 329 FPQEKGKATGIYYSAGSIATFTIPLITARISEMSIAHIMWFDTGIAAAGFLLALFI 384
Cdd:cd17474 318 PEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
9-383 |
1.12e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 56.46 E-value: 1.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 9 AVGLYFNYFVHGMGVILMSLNMSSL--EQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFF 86
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLaaEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 87 IGILYAQTIFVAYACGFLAGMANSFLDAGTYPSLMEAFP-RSPSTANILIKAFVSGGQFLLPIIISLLV-WANMWFGWSF 164
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPsKRRGFALGLLQSGWALGALLAALVASLLIpLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 165 LLAGAIMLINALFLLRcpfppypgrilkpkisqapvtgvhhcslIDLISYTLYGYISMATFYLISQWLAQYGQFVAGMSY 244
Cdd:cd17316 161 LFLIGALPALLALLLR----------------------------RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSP 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 245 TQSIKLLSIYTCGSLLCVFITAPLVRKTIRSTTLLMFYTFISFIALLTVCLHPQAYVVMIFAFVIGFSSAGGVVQIGLTL 324
Cdd:cd17316 213 ATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAY 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446720356 325 MAARFP-QEKGKATGIYYSAGSI-ATFTIPLITARISEMSIAHIMWFDTGIAAAGFLLALF 383
Cdd:cd17316 293 LAELFPtEVRATGVGLSYNLGRLgGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
39-384 |
1.12e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 56.47 E-value: 1.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 39 TSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILYA-----QTIFVAYACGFLAGMANSFLD 113
Cdd:cd06173 31 GSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLallgsLSLWLLLVLAFLLGIASAFFG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 114 AGTYPSLMEAFPRSP-STANILIKAFVSGGQFLLPIIISLLVwANMWFGWSFLLAGAIMLINALFLLRCPFPPYPGRILK 192
Cdd:cd06173 111 PARQALLPELVPKEQlVRANALNSLATQLARIIGPALGGLLV-ALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGES 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 193 PKISQAPVTGVHHC---SLIDLISYTLYGYISMATFYLISQwLAQYGQFVAGMSYTQSIKLLSIYTCGSLLcVFITAPLV 269
Cdd:cd06173 190 SSLLLRDLREGLRYlrrSPLLRLLLLALALFALLGGALTVL-LPLLAKEVLGGGAAGYGLLLAAFGVGALL-GALLLGRL 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 270 RKTIRSTTLLMFYTFISFIALLTVCLHPQAYVVMIFAFVIGFSSAGGVVQIGlTLMAARFPQEK-GKATGIYYSAGSIAT 348
Cdd:cd06173 268 SKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLN-TLLQLRVPDELrGRVFSVYNALNSGAM 346
|
330 340 350
....*....|....*....|....*....|....*.
gi 446720356 349 FTIPLITARISEMSIAHIMWFDTGIAAAGFLLALFI 384
Cdd:cd06173 347 PLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
35-386 |
3.87e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 54.91 E-value: 3.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 35 QQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILYAQTIFVAYACGFLAGMANSFLDA 114
Cdd:cd17489 24 HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 115 GTYPSLMEAFPRSPSTANILIKAFVSGGQFLLPIIISLLVWANMWFGWSFLLAGAIMLINALFLLRCPFPPYPGRILKPK 194
Cdd:cd17489 104 AAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 195 ISQAPV-----TGVHHCSLIDLISYTLYGYISMATFYLISQWLAQYGQFvagmsytqsiklLSIYTCGSLLCVFITAPLV 269
Cdd:cd17489 184 GTRAFRrlvekKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLF------------FTVYAIALLLSRPFSGKLS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 270 RKTIRSTTLLMFYTFIsFIALLTVCLHPQAYVVMIFAFVIGFssAGGVVQIGLTLMAARF--PQEKGKATGIYYSAGSIA 347
Cdd:cd17489 252 DRKGPKTVIIPGLLLL-ALGLLLLSFAGSPWMLLLAAVLYGL--GFGLLFPALQALAVDLvpPHRRGAANGTFFIFFDLG 328
|
330 340 350
....*....|....*....|....*....|....*....
gi 446720356 348 TFTIPLITARISEMSIAHIMWfdtgIAAAGFLLALFIGY 386
Cdd:cd17489 329 IGLGGLLLGLVAELFGYRAMF----LLAAVVVLLALVLY 363
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
61-397 |
1.09e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 53.75 E-value: 1.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 61 IAGMLSDRFG-----RRPFIILGTACYLIFFIGILYA------QTIFVAYACGFLAGMANSFLDA--GTYPSLMEAFPRS 127
Cdd:COG2211 65 LIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTApdlsptGKLIYALVTYLLLGLAYTLVNIpySALGAELTPDYEE 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 128 PSTANILIKAFVSGGQFLLPIIISLLVWA-----NMWFGWSFLLAGAIMLINALFLLRCPFPPYPGRILKPKISQAPVTG 202
Cdd:COG2211 145 RTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKAL 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 203 VHHCSLIDLISYTLygyISMATFYLISQWLAQYGQFVAGMSYTQSIKLLSIYTCGSLLCVFITAPLVRKTIRSTTLLMFY 282
Cdd:COG2211 225 LKNRPFLLLLLAYL---LFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGL 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 283 TFISFIALLTVCLHPQAYVVMIFAFVIGFSSAGGVVQIGLTLMAARFPQEKGK----ATGIYYS--------AGSIATFT 350
Cdd:COG2211 302 LLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKtgrrREGLYFGiftfaiklGQALAGAL 381
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 446720356 351 IPLI--------TARISEMSIAHIMWFDTGIAAAGFLLALFIGYRSRAESQHHAE 397
Cdd:COG2211 382 AGLLlalfgyvaGAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAE 436
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
38-384 |
1.51e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 52.94 E-value: 1.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 38 HTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILYAQTIFVAYACGFLAGMANSFLDAGTY 117
Cdd:cd17324 30 GVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 118 PSLMEAFPRSPSTANI-LIKAFVSGGQFLLPIIISLLvwaNMWFGW--SFLLAGAIMLInALFLLRCPFPPYPGRilKPK 194
Cdd:cd17324 110 AYAADLVPPEKRGRAIgLVFSGLTLGLVLGRPLGGLL---GQLLGWraAFLAIAVLALL-AALLLWRLLPSLPPK--KPG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 195 ISQAPVTGVHHCSLIDLISYTLYGYISMATFYLISQWLAQYGQFVAGMSYTQSIKLLSIYTCGSLLCVFITAPLV-RKTI 273
Cdd:cd17324 184 SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLAdRGGR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 274 RSTTLLMFYTFISFIALLTVCLHPQAYVVMIFAFVIGFSSAGGVVQiglTLMAARFPQEKGKATGIYYSAGSIATFTIPL 353
Cdd:cd17324 264 RALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQ---TRVLRLAPEARGLASSLYLAAYNLGGALGAA 340
|
330 340 350
....*....|....*....|....*....|.
gi 446720356 354 ITARIsemsIAHIMWFDTGIAAAGFLLALFI 384
Cdd:cd17324 341 LGGLV----LDHGGWAGVGWVGAALLLLALL 367
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
21-348 |
2.90e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 52.18 E-value: 2.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 21 MGVILMSLNMSSL-------EQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILYAQ 93
Cdd:cd17321 3 LAVFLAALDVTIVnvalptiARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 94 TIFVAYACGFLAGMANSFLDAGTYPSLMEAFPRSP-STANILIKAFVSGGQFLLPIIISLLVwANMWFGWSFLLAGAIML 172
Cdd:cd17321 83 SLAFLIAARALQGIGAAAIMPASLALIAATFPGERrGRALGLWGAVVGIGAALGPLLGGLLL-ELFGWRWIFLINVPIGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 173 InALFLLRcpfppypgrilkpkisqaPVTGVhhcslidlisyTLYGYISMATFYLISQWLAQYGQFVAGMSYTQSIKLLS 252
Cdd:cd17321 162 V-ALLLAR------------------TFSGA-----------VLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 253 IYTCGSLLCVFITAPLV-RKTIRSTTLLMFYTFISFIALLTVCLHPQAYVVMIFAFVIGFSSAGGVVQIGLTLMAARFPQ 331
Cdd:cd17321 212 PLALAMLVAAPLAGRLAdRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPK 291
|
330
....*....|....*...
gi 446720356 332 EK-GKATGIYYSAGSIAT 348
Cdd:cd17321 292 EKaGAASGILNTARQLGG 309
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
38-362 |
3.30e-07 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 51.78 E-value: 3.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 38 HTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILYAQTIFVAYAC-GFLAGMANSFLDAGT 116
Cdd:cd17352 34 GESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTyGVLGGLGLGLIYSPA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 117 YPSLMEAFPRSPSTANILIKAFVSGGQFLLPIIISLLVwANMWFGWSFLLAGAIMLINALFLLRcpfppypGRILKPKIS 196
Cdd:cd17352 114 IVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLL-DNYGWRGALLILGGLCLNLCVCGLL-------LRLLKDPTF 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 197 QAPVTGVhhcslidliSYTLYGYISMATF---YLISQwlaqygqfvaGMSYTQSIKLLSIYTCGSLLCVFITAPL-VRKT 272
Cdd:cd17352 186 VLLALGV---------SFAMLGFFVPFVYlpsYAKSL----------GIDESDAAFLLSIIGISDIVGRILLGLLaDKPR 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 273 IRSTTLLMFYTFISFIALLTVCLHPQAYVVMIFAFVIGFSSAGGVVQIGLTLMAARFPQEKGKATGIYYSAGSIATFTIP 352
Cdd:cd17352 247 IGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGP 326
|
330
....*....|
gi 446720356 353 LITARISEMS 362
Cdd:cd17352 327 PIAGLLRDYT 336
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
63-382 |
5.15e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 51.40 E-value: 5.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 63 GMLSDRFGRRPFIILGTACYLIFFIGILYAQTIFVAYACGFLAGMANSFLDAGTYPSLMEAFPRSPSTANILIKAFVSGG 142
Cdd:cd17478 52 GYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLG 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 143 QFLLPIIISLLVwaNMWFGWSFLLAGAIMLINALFLLRC---PFPPYPGRILKPKISQAPVTGVHHCSLIDLISYTLYGY 219
Cdd:cd17478 132 FALGPLIAAALV--ALFGGLGLLILLIIPGLAVALLLLRlrpLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSW 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 220 ISMATFYLISQWLAQYGQFVAGMSYTQSIKLLSIyTCGSLLCVFITAPLVRKTIrsttllMFYTFISFIALLTVCLHPQA 299
Cdd:cd17478 210 VLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAG-AIGTLIGGPLSDRFGRRRV------IIASLLLAAPFLLLFLLTPG 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 300 YVVMIFAFVIGF---SSAGGVVQIGLTLMaarfPQEKGKATGIYYS-AGSIATFTIPLITARISEMSIAHIMWFDTGIAA 375
Cdd:cd17478 283 IWSYILLVLAGFllfASFPVTVVLAQELL----PGNVGLASGLMMGlSFGLGGIGAPVLGALADAFGLESVLLILALLPL 358
|
....*..
gi 446720356 376 AGFLLAL 382
Cdd:cd17478 359 LGALLAF 365
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
33-354 |
1.25e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 49.93 E-value: 1.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 33 LEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILYAQTIFVAYACGFLAGMANSFL 112
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 113 DAGTYPSLMEAFPRSPSTANILIK-AFVSGGQFLLPIIISLLVWANMWfGWSFLLAGAIMLINALFLLRCPFPPypgril 191
Cdd:cd17475 102 QPGGGRAIMRWFPPRERGLAMGIRqTGVPLGGALAAALLPPLALHYGW-RAAFVVAGLVSILAAVLFWLFYREP------ 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 192 KPKISQAPVTGVHHCSLIDLISYTLYGYISMATFYLISqwlAQYGQFVAGMSYTQSIKLLSIYTCGSLL-CVFITAPLVR 270
Cdd:cd17475 175 PAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVA---PQFALLTFLLLFLHDHLGLSVVAAGALLaVAQLGGALGR 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 271 -------------KTIRSTTLLMFYTFISFIALLTVCLHPQAYVVMIFAFVIGFsSAGGVVQIGLTLMAARFPQEK-GKA 336
Cdd:cd17475 252 iglgrvsdrvfggRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGL-FAIGWNGLYLTLVAESAGPEQaGTA 330
|
330
....*....|....*...
gi 446720356 337 TGIYYSAGSIATFTIPLI 354
Cdd:cd17475 331 LGLANTINFIGIAIGPPL 348
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
10-382 |
1.44e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 49.92 E-value: 1.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 10 VGLYFNYFVHGMGVILMSLNMSsleQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGI 89
Cdd:cd17329 6 IGSFLNRLGFFMVWPFMAIYLH---QQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 90 LYAQTIFVAYACGFLAGMANSFLDAGTYPSLMEAFPRSPST-ANILIKAFVSGGQFLLPIIISLLVWANmwFGWSFLLAG 168
Cdd:cd17329 83 GFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTrAFSLLYWAINLGVAIGPLLGGLLLLYS--FRLLFLAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 169 AIMLINALFLLRC--PFPPYPGRILKPKISQAPVTGVHHCslidliSYTLYGYISMATFYLISQWLAQYGQFVAGMSYTQ 246
Cdd:cd17329 161 VLFLLAALVLLFLlpETRPKRRAAEKTEILRGYKIVLRDR------AFLLFLLASFLISLIYFQLESTLPVYVVEILGLG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 247 SIKLLSIYTCGSLLCVFITAPLVR----KTIRSTTLLMFYTFISFIALLTVCLHPQAYVVMIFAFVIGFSSAGGVVQigl 322
Cdd:cd17329 235 ESLLGLLLALNALLIVLLQFPVARlverFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQ--- 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446720356 323 TLMAARFPQEK-GKATGIYYSAGSIATFTIPLITARISEMSIAHIMWFdtGIAAAGFLLAL 382
Cdd:cd17329 312 TLVAALAPPDKrGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWL--ILAALGLIAAA 370
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
61-386 |
1.82e-06 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 49.55 E-value: 1.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 61 IAGMLSDR----FGRR-PFIILGTACYLIFFIGILYAQTIFVAYACG-------------FLAGMANSFLDAGTYPSLME 122
Cdd:cd17313 53 LVGSLSDRcnsrIGRRrPFILVGAPLAALGLILIPNAADIGLALGDGprtwalvlfvlgiVLLDFAMNVCQGPVRALLPD 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 123 AFPRS-PSTANILIKAFVSGGQ---FLLPIIISLLVWANMWFG----WSFLLAGAIMLInALFLLRCPFPPYPGRILKPK 194
Cdd:cd17313 133 LVPPEqRSKANGIINFMGGLGGvlgYLLGAILWDHNWFGFALGgnlkVPFYIGAIILLV-CVLVTLFFVKEPPLSPEAGE 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 195 ISQAPVTGVHHCSLIDLISY-----------TLYGYIS-MATFYLISQWLAQ---YGQFVAGMSYTQSIK----LLSIYT 255
Cdd:cd17313 212 HSENPSLGEVLKSLLKLLKImprsllrlllvIFFWWIAfFPFELFFTDYMGEevyHGTSAASSHYGAGVRmgawGLLIFS 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 256 CGSLLCVFITAPLVRKtIRSTTLLMFYTFISFIALLTVCLHPQAYVVMIFAFVIGFSSAggVVQIG----LTLMAARFPQ 331
Cdd:cd17313 292 LAFLIFSLPIGKLGKK-IGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWA--TININpyplVSDYHSESGR 368
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 446720356 332 EKGKATGIYYSAGSIATFTIPLITARISEMSIAHIMWfdtGIAAAGFLLALFIGY 386
Cdd:cd17313 369 GQGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVF---PVAAVASFLSLVGAL 420
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
44-354 |
1.93e-06 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 49.50 E-value: 1.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 44 VSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILYAQTIFVAYACGFLAGMAN-SFLDAGTYpsLME 122
Cdd:cd17330 36 VGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGgNVSVAQAY--IAD 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 123 AFPRSPSTANILIKAFVSGGQFLL-PIIISLLVWANMwFGWSFLLAGAIMLINALFLLRcpFPPYPGRIlkpkisqapvt 201
Cdd:cd17330 114 ITDEEERAKAFGIISAAFGLGFILgPALGGFLSTPYG-YALPFLVAAALALLNLVLVLF--FLPPLRRL----------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 202 gvhhCSLIDLISYTLYGYISMATFYLISQWlaQYGQFVAGMsytqsikLLSIYTCGSLLCVFITAPLVRKTIRSTTLLMF 281
Cdd:cd17330 180 ----LLVYFLIALAFAGLESVFSLFLKDRF--GFSPSQIGL-------LLALVGIAGILAQLLLIPRLAKRLGERKLLRL 246
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446720356 282 YTFISFIALLTVCLHPQAYVVMIFAFVIGFSSagGVVQIGLTLMAARF--PQEKGKATGIYYSAGSIATFTIPLI 354
Cdd:cd17330 247 GLLLAIIGLLLLPFASSVPLLVLAAAILAFGT--GIVFPALSALLSKSvpSKEQGKAQGIIQSLQSLARIIGPLL 319
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
30-351 |
3.78e-06 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 48.73 E-value: 3.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 30 MSSLEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILYAQTIFVAYACGFLAGMAN 109
Cdd:cd17320 22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 110 SFLDAGTYPSLMEAFPRspsTANILIKAFVSGGQFLLPIIISLL-VWANMWFGWS---FLLAGAIMLINALFLLRCPFPP 185
Cdd:cd17320 102 AAGSVVARAIVRDLYSG---AELAKIFSLLMMILAIAPALAPLLgGLLLLFFGWRaifVFLALLGLLLLLLVLLFLPETL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 186 YPGRIlKPKISQAPVTGVHHCSLIDLISYTLYGYISMATFYLISQWLAQYGQFVAGMSYTQSIKLLSIYTCGSLLCVFIT 265
Cdd:cd17320 179 PEEKR-KPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLN 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 266 APLVRKtIRSTTLLMFYTFISFIA----LLTVCLHPQAYVVMIFAFVIGFSSAGGVVQIGLTLMAARFPQEKGKATG--- 338
Cdd:cd17320 258 GRLVRR-FGPRRLLRLGLLLLLAAalvlLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASAllg 336
|
330
....*....|....
gi 446720356 339 -IYYSAGSIATFTI 351
Cdd:cd17320 337 fLQFLIGALAGALV 350
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
4-180 |
6.36e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 47.95 E-value: 6.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 4 RYFPTAVGLYFNYFVHGMGVILMS----------LNMSSLEQQWHTSAAGVSIVISSLGIGRLSVLLIagmlsdRFGRRP 73
Cdd:cd17319 176 FYLRQVWGLALGYFGINYALYGLLtwlptylkqaRGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLL------RGARRL 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 74 FIILGTACYLIFFIGILYAQTIFVAYACGFLAGMANSFLDAGTYPSLMEAFPRSPS-TANILIKAFVSGGQFLLPIIISL 152
Cdd:cd17319 250 VIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAaTAGGLINSGGNLGGFVAPLLIGY 329
|
170 180
....*....|....*....|....*...
gi 446720356 153 LVWANMWFGWSFLLAGAIMLINALFLLR 180
Cdd:cd17319 330 LVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
13-384 |
7.79e-06 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 47.68 E-value: 7.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 13 YFNYFVHGMGVILMSLNMSSLEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILYA 92
Cdd:cd17371 5 FLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 93 QTIFVAYACGFLAGMA-NSFLDAGTYPSLMEAFPRSPSTANILIKAFVSGGQFLLPIIISLLV-WANMWFGWSFLLAGAI 170
Cdd:cd17371 85 QNYWQLLILRALAGLGfGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFpLLPPEIAWRVLFLLGA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 171 MLINALFLLRcPFPPYPGRILKPKISQAPVTGVHHCSLID-------LISYTLYGYISMATFYLISQWLAQYGQFVAGMS 243
Cdd:cd17371 165 LPALLVLFIR-RFVKEPPQWQAARAARRHFADRPSLRELFsppllrtTLLASLLATGALGGYYGITTWLPSYLTGERGLS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 244 YTQSIKLLSIYTCGSLLCVFITAPLVRKTIRSTTLLMFYtFISFIALLTVCLHPQAYVVMIFAFVIGFSSAGGVVQIGLT 323
Cdd:cd17371 244 FEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFA-LGSAISILLYFFLPLSPTLILILGFPLGFFASGPFSGMGA 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446720356 324 LMAARFPQE-KGKATGIYYSAGSIATFTIPLITARISEM-SIAHIMWFDTGIA-AAGFLLALFI 384
Cdd:cd17371 323 YLTELFPTAvRATAQGFCYNVGRIIGALFPFLVGFLATSgSLGTAIAVFAAVYyIAGLVLALLL 386
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
39-179 |
1.29e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 46.80 E-value: 1.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 39 TSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILYAQTIFVAYACGFLAGMANSFLDAGTYP 118
Cdd:cd17473 230 GSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNS 309
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446720356 119 SLMEAFPRSPSTANI-LIKAFVSGGQFLLPIIISLLVWANMWFGWSFLLAGAIMLINALFLL 179
Cdd:cd17473 310 WAMSLVPPELRGRAMgIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLL 371
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
30-124 |
1.42e-05 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 46.86 E-value: 1.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 30 MSSLEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILYAQTIFVAYACGFLAGMAN 109
Cdd:PRK15402 36 MLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGL 115
|
90
....*....|....*
gi 446720356 110 SFLDAGTYPSLMEAF 124
Cdd:PRK15402 116 CFIGAVGYAAIQESF 130
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
27-360 |
1.73e-05 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 46.60 E-value: 1.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 27 SLNMSSLEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILYAQTIFVAYACGFLAG 106
Cdd:TIGR00881 15 ALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 107 MANSFLDAGTYPSLMEAFPRSP--STANILIKAFVSGGQFLLPIiisLLVWANMWFGW--SFLLAGAIMLINALFLLRC- 181
Cdd:TIGR00881 95 IFQGMGWPPCGRTVTKWFSRSErgTWVSFWNCSHNVGGGLLPPL---VLFGIAELYSWhwVFIVPGIIAIIVSLICFLLl 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 182 ----------PFPPYPGRIL------KPKISQAPVTGVHHCSLIDLISYTLYGYI-SMATFYLISQWLAQYGQFVAGMSY 244
Cdd:TIGR00881 172 rdspqscglpPAEEMPNEEPdgdaekKEEELTKKQIFLQYVLLNKVLWYISLGYVfVYVVRTGILDWSPLYLTQEKGFSK 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 245 TQSIKLLSIYT----CGSLLCVFITAPLVRKTIRSttLLMFYTFISFIALLTVCLHPQA--YVVMIFAFVIGFSSAGGVV 318
Cdd:TIGR00881 252 EKASWAFTLYElgglVGTLLAGWLSDKLFNGRRGP--LAVFFMALIIVSLLVYWLNPAAnpLMDLICLFALGFLVYGPQM 329
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 446720356 319 QIGLTLMAARFPQEKGKATGIYYSAGSIATFTIPLITARISE 360
Cdd:TIGR00881 330 LIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLAD 371
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
33-384 |
3.35e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 45.68 E-value: 3.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 33 LEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILYAQTIFVAYAC-GFLAGMANSF 111
Cdd:cd17353 29 LSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGyGVLGGIGAGI 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 112 LDAGTYPSLMEAFPRSPSTANILIKAFVSGGQFLLPIIISLLVwANMWFGWSFLLAGAIMLI---NALFLLRCPfPPYPG 188
Cdd:cd17353 109 GYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLI-NTVGVPTTFLILGIIFLIiivIGAFLIRDP-PKGWV 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 189 RILKPKISQAPVTGVHHCS----LIDLISYTLYGYISMATF---YLISQWlAQYGQFVAGMSYTQSIKLLSIYTCGSLLC 261
Cdd:cd17353 187 PPGVDPLANNAENSPRDYTpremLRTPTFWLLWLMFFLNATaglMLIGQA-KPIGQEFAGLDAGIAALAVSILSIFNGGG 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 262 VFITAPLVRKTIRSTTLLMFYTFISFiALLTVCLHPQAYVVMIFAFVIGFSSAGGVVQIGLTLMAARF-PQEKGKATGIY 340
Cdd:cd17353 266 RPFWGWLSDKIGRKNTLSIAFLIQGV-AMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFgTKNAGTNYGLL 344
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 446720356 341 YSAGSIATFTIPLITARISEMSIAHI-MWFDTGIAAAGFLLALFI 384
Cdd:cd17353 345 YTAKGVGGLIGPIIAAYVLYTGGYNAaFIIAAALSLVALALALLL 389
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
63-384 |
5.88e-05 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 44.90 E-value: 5.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 63 GMLSDRFGRRPFIILGTACYLIFFIGILYAQTIFVAYACGFLAGmansfldAGTYPSLMEAFPRSPSTANILIKAF---- 138
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG-------SGAISSVVMALLADLTREENRTKAMalig 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 139 -VSGGQFLLPIIISLLVWANMWFGWSFLLAGAIMLInALFLLRCPFPPYPGRILKPKISQAPVTGVH---HCSLIDLISY 214
Cdd:cd17472 126 aSIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLV-SLLILLFFVPDPPKIVQISEKEKKKLKKLLknkRLLRLDFSIF 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 215 TLYGYIsMATFYLISQWLAQYGQfvagmsytQSIKLLSIYTCGSLLCVFITAPLVRKTIRSTTllMFYTFISFIALLTVC 294
Cdd:cd17472 205 ILHFVL-MAFFYILPLLLTQLGG--------GKGQLWKVYLPAILIGFILMVPFVIYAEKKGK--MKQVFVSSILLIAVG 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 295 ----LHPQAYVVMIFAFVIGFSSAGGVVQIGLTLMAARF--PQEKGKATGIYYSAGSIATFTIPLITARISEMSIAHIMW 368
Cdd:cd17472 274 flllLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIapKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVF 353
|
330
....*....|....*.
gi 446720356 369 FDTGIAAAGFLLALFI 384
Cdd:cd17472 354 LTILILALLWLLVSFL 369
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
45-180 |
1.02e-04 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 41.87 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 45 SIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILYAQTIFVAYACGFLAGMANSFLDAGTYPSLMEAF 124
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 446720356 125 PRSPSTANIlikAFVSGGQFLLPIIISLL-VWANMWFGWS--FLLAGAIMLINALFLLR 180
Cdd:TIGR00880 81 PPEERGVAL---GLMSAGIALGPLLGPPLgGVLAQFLGWRapFLFLAILALAAFILLAF 136
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
10-180 |
2.12e-04 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 43.02 E-value: 2.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 10 VGLYFNYFVHGMGVILMSLNMSSLEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGI 89
Cdd:cd17393 2 LAVAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 90 LYAQTIFVAYACGFLAGMANSFLDAGTYPSLMEAFPRSPSTANILIKAFVSGGQFLLPIIISLLVWANMWFGWSFLLAGA 169
Cdd:cd17393 82 GLAPSVPALALALFLFGAANGALDVAMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLGAAAIGAGVSPGVHLLAAAV 161
|
170
....*....|.
gi 446720356 170 IMLINALFLLR 180
Cdd:cd17393 162 LLLLAALVAIR 172
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
3-339 |
2.29e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 43.11 E-value: 2.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 3 NRYFPTAVGLYF-NYFVHGMGVILMSLNMSSLEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTAC 81
Cdd:TIGR00895 12 SRYQWRAIILSFlIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 82 YLIFFIGILYAQTIFVAYACGFLAGMANsfldAGTYPSLM----EAFP--RSPSTANILIKAFV---SGGQFLLPIIISL 152
Cdd:TIGR00895 92 FSVFTLLCALATNVTQLLILRFLAGLGL----GGLMPNLNalvsEYAPkrFRGTAVGLMFCGYPigaAVGGFLAGWLIPV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 153 LVWANMwfgwsFLLAGAIMLINALFLLRcpFPPYPGRILkpkISQAPVTGVHHCSLID---------------------- 210
Cdd:TIGR00895 168 FGWRSL-----FYVGGIAPLLLLLLLMR--FLPESIDFL---VSKRPETVRRIVNAIApqmqaeaqsalpeqkstqgtkr 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 211 ------------LISYTLYGYISM--ATFYLISQWLAqYGQFVAGMSYTQSIKLLSIYTCGSLLCVFITAPLVRKtIRST 276
Cdd:TIGR00895 238 svfkalfqgktaRITVLLWLLYFMllVGVYFLTNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADR-LGPR 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446720356 277 TLLMFYTFISFIALLTVCLHPQAYVVMIFAFVIGFSSAGGvvQIGLTLMAARFPQEKGKATGI 339
Cdd:TIGR00895 316 VTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGG--QSGLYALMALFYPTAIRATGV 376
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
20-344 |
3.14e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 42.57 E-value: 3.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 20 GMGVILMSLNMSSLEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILYAQTIFVAY 99
Cdd:cd17365 12 GFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 100 ACGFLAG------MANSFLDAGTYpslmeAFPRSPSTANILIKAFVSGGQFLLPIIISLLVWAnmwFGW-SFLLAGAIML 172
Cdd:cd17365 92 LLRFLTGlglgaaMPNAITLVSEY-----APARRRSLAVTLMFCGYPLGAALGGFLAAALIPA---FGWrSVFLLGGVPP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 173 INALFLLRcpfppypgrilkpkisqapvtgvhhcslidlISYTLYG--YISMATFYLISQWLAQYGQfVAGMSYTQSIKL 250
Cdd:cd17365 164 LILLPLLR-------------------------------GTLLLWVtfFMGLLLVYLLNSWLPKLMV-EAGYSLSQALTI 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 251 LSIYTCGSLLCVFITAPLVRKTIRSTTLLMFYtFISFIALLTVCLHPQAYVVM-IFAFVIGFSSAGGvvQIGLTLMAARF 329
Cdd:cd17365 212 TLLLNIGGVIGSLLLGWLADRFGPKRVLALFF-ALGAVSLALLGVSPASLVLLyVLVFLAGACVNGA--QVGLYALAARF 288
|
330
....*....|....*
gi 446720356 330 PQEKGKATGIYYSAG 344
Cdd:cd17365 289 YPTEVRATGVGWALG 303
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
44-153 |
3.26e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 42.18 E-value: 3.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 44 VSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILYAQTIFVAYACGFLAGMANSFLDAGTYPSLMEA 123
Cdd:cd17317 27 VALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEI 106
|
90 100 110
....*....|....*....|....*....|.
gi 446720356 124 F-PRSPSTANILIKAFVSGGQFLLPIIISLL 153
Cdd:cd17317 107 VgPKYRSFVGILFGLFWALGYMLLALLAYLI 137
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
60-147 |
3.38e-04 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 42.28 E-value: 3.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 60 LIAGMLSDRFGRRPFIILGTACYLIFFIGILYAQTIFVAYACGFLAGMANSFLDAGTYPSLME-AFPRSPSTANILIKAF 138
Cdd:cd17374 53 LIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEwTTPRHRALAITLTSCF 132
|
....*....
gi 446720356 139 VSGGQFLLP 147
Cdd:cd17374 133 FSIGQMLLA 141
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
31-114 |
3.94e-04 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 42.39 E-value: 3.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 31 SSLEQQWHTSAA-GVSIVISSLgIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIF-----------FIGILYAQTIFVA 98
Cdd:PRK10642 275 SYLSHNLHYSEDhGVLIIIAIM-IGMLFVQPVMGLLSDRFGRRPFVILGSVALFVLaipafilinsnVIGLIFAGLLMLA 353
|
90
....*....|....*.
gi 446720356 99 YACGFLAGMANSFLDA 114
Cdd:PRK10642 354 VILNCFTGVMASTLPA 369
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
44-185 |
5.58e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 41.93 E-value: 5.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 44 VSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILYAQTIFVAYACGFLAGMANsfldAGTYPSLM-- 121
Cdd:TIGR00898 129 VDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGI----GGIWVQAVvl 204
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446720356 122 --EAFPRSP-STANILIKAFVSGGQFLLPiiisLLVWANMwfGWSFLLAgAIMLINALFLLRCPFPP 185
Cdd:TIGR00898 205 ntEFLPKKQrAIVGTLIQVFFSLGLVLLP----LVAYFIP--DWRWLQL-AVSLPTFLFFLLSWFVP 264
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
34-180 |
5.89e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.83 E-value: 5.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 34 EQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILYAQTIFVAYACGFLAGMANSFLD 113
Cdd:cd06173 236 KEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFN 315
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446720356 114 AGTYPSLMEAFP-----RSPSTANILIKAFVSGGQFLLPIIISLLVWAnmwfgWSFLLAGAIMLINALFLLR 180
Cdd:cd06173 316 VPLNTLLQLRVPdelrgRVFSVYNALNSGAMPLGALLAGLLADALGLS-----AVFLLAGALLLLAALLLLL 382
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
17-108 |
6.18e-04 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 41.79 E-value: 6.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 17 FVHGMGV----ILMSLNMSSLEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILYA 92
Cdd:cd17358 12 FSFGIAVgwssPALPSLMSDNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFA 91
|
90
....*....|....*.
gi 446720356 93 QTIFVAYACGFLAGMA 108
Cdd:cd17358 92 KDVWMLYLGRFLAGFG 107
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
216-384 |
7.10e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 41.40 E-value: 7.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 216 LYGYISMATFYLISQWLAQYGQFVAGMSYTQSIKLLSIYTCGSLLCVFITAPLVRKTIRSTTLL---MFYTFISFIALLT 292
Cdd:cd17502 174 IFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPLIvigTILMSVGAGLLTT 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 293 VCLHPQAYVVMIFAFVIGFSSAGGVVQIGLTLMAARFPQEKGKATGIYYSAGSI-ATFTIplitarisemSIAHIMWFDT 371
Cdd:cd17502 254 LTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLgGTLGV----------AITDVFLVAL 323
|
170
....*....|...
gi 446720356 372 GIAAAGFLLALFI 384
Cdd:cd17502 324 ALAALAFLLSLFL 336
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
30-384 |
7.43e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 41.49 E-value: 7.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 30 MSSLEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILYAQTIFVAYACGFLAGMAN 109
Cdd:cd17355 26 IIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 110 SfldAGTYPSLMEA-----FPRSPSTANILIKAFVSGGQFLLPiiiSLLVWANMWFGWS-----FLLAGAIMLINALFLL 179
Cdd:cd17355 106 A---GTLAAVAFATvaawwFERRRGLALGILTAGGGLGSLVFL---PLGAALIEAFGWRtallvLALLALLVLVPVLLLL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 180 RCPFPPYPGRILKPKISQAPVTGV-----HHCSLIDLISYTLYGYISMAtfylISQWLAQYGQFvAGMSYTQSIKLLSIY 254
Cdd:cd17355 180 RRRPADLALRAYDDASPASPGSTLkealrSASFWLLALAFFLCGFAVVG----LIVHLVPYLAD-RGISPAAAAVALALI 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 255 TCGSLLCVFITAPLVRKTIRSTTLLMFYTFISFIALLTVCLHPQAYVVMIFAFVIGFsSAGGVVQIGLTLMAARFPQEK- 333
Cdd:cd17355 255 GLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGL-GWGATVPLTAALAARYFGARSy 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 446720356 334 GKATGIYYSAGSIATFTIPLITARISEM--SIAHIMWFDTGIAAAGFLLALFI 384
Cdd:cd17355 334 GTLFGLVFAPHQLGSALGPWLGGLLYDRtgSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
32-108 |
7.59e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 41.40 E-value: 7.59e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446720356 32 SLEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILYAQTIFVAYACGFLAGMA 108
Cdd:cd17359 26 FLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLA 102
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
17-368 |
2.80e-03 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 39.67 E-value: 2.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 17 FVHGMGVILMSLNMS-------SLEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGI 89
Cdd:TIGR00710 8 LLLGCLSILGPLGIDmylpafpEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 90 LYAQTIFVAYACGFLAGMANSFLDAGTYPSLMEAFPRSPSTAnilIKAFVSGGQFLLPIIISLL-VWANMWFGW----SF 164
Cdd:TIGR00710 88 ALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSR---IYSILMPVLALAPAVAPLLgGYILVWLSWhaifAF 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 165 LLAGAIMLINALFLLRCPFPPYPGRILKPKISQAPVTGVHHCSL------IDLISYTLYGYISMATFYLISqwlaQYGQF 238
Cdd:TIGR00710 165 LSLAGILLSALIFFILPETLPYEARIQISTYFETFLLLLKSKMFwgyaliYGASFGGFFAFFSGAPFVYID----IMGVS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 239 VAGMSYTQSIKLLSIYTCGSLLCVFITAPLVRKTIRSTTLLMFYTFISFIALLTVCLHPQAYVVMIFAFVIGFSSAggVV 318
Cdd:TIGR00710 241 PSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGIGNSM--IS 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 446720356 319 QIGLTLMAARFPQEKGKATGIYYSAGSIATFTIPLITARISEMSIAHIMW 368
Cdd:TIGR00710 319 SIAMAYALEDFPHVAGTASALFGTLRLVLGAIVGYLVSLIHGNTAWPMSL 368
|
|
| PRK10489 |
PRK10489 |
enterobactin transporter EntS; |
40-189 |
2.99e-03 |
|
enterobactin transporter EntS;
Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 39.58 E-value: 2.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 40 SAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGI-----LYAQTIFVAYAC----GFLAGMANS 110
Cdd:PRK10489 50 STLQVGLSVTLTGGAMFIGLMVGGVLADRYDRKKLILLARGTCGLGFIGLalnafLPEPSLLAIYLLglwdGFFGSLGVT 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 111 FLDAGTyPSLMeafPRSP-STANILIKAFVSGGQFLLPIIISLLVwANMWFGWSFLLAGAIMLINALFLLRCPFPPYPGR 189
Cdd:PRK10489 130 ALLAAT-PALV---GRENlMQAGAITMLTVRLGSVISPALGGLLI-AAGGVAWNYGLAAAGTFITLLPLLRLPALPPPPQ 204
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
46-386 |
2.99e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 39.48 E-value: 2.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 46 IVISSLGIGRLSvlLIAGMLSDRFGRRPFIILGTACYLIFFIGILYAQTIFVAYACGFLAGMANSFLDAGTyPSLMEAFP 125
Cdd:cd17473 41 LTLPALFIALFA--PLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLA-TALIGDYF 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 126 RSPSTANIL--IKAFVSGGQFLLPIIISLLVWANmWFG--WSFLLAGAIMLINALFLlrcpfpPYPGRILKPKISQAPVT 201
Cdd:cd17473 118 EGEERAKMLglQSAAMSLGGVVFLLLGGALAEIG-WRApfLVYLLALPVLILVLLFL------PEPARKSKSAASPGAAT 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 202 gVHHCSLIDLISYTLYGYISMATFYLISQWLAQYGQFVAGMSYTQSIKLLSIYTCGSLLCVFITAPLVRKtiRSTTLLMF 281
Cdd:cd17473 191 -AAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRR--LGKRRLLA 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 282 YTFISF-IALLTVCLHPQAYVVMIFAFVIGFssAGGVVQIGLTLMAARF--PQEKGKATGIYYSAGSIATFTIPLITARI 358
Cdd:cd17473 268 IGFALMaLGFLLLALASGLWVVLLGAILAGL--GFGLLLPTLNSWAMSLvpPELRGRAMGIVTSAFFLGQFLSPLVLGPL 345
|
330 340
....*....|....*....|....*...
gi 446720356 359 SEMSIAHimwFDTGIAAAGFLLALFIGY 386
Cdd:cd17473 346 VNLTGGL---SGAFLILGVLALVLAIVL 370
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
30-179 |
4.69e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 38.71 E-value: 4.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 30 MSSLEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILYAQTIFVAYACGFLAGMAN 109
Cdd:cd17323 22 LPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFG 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446720356 110 S---FLDAGTYPSLMeaFPRSPSTANILIKAFVSGGQFLLPIIISLLV--WANMWFGWSFLLAGAIMLINALFLL 179
Cdd:cd17323 102 SsplAIGAGTIADLF--TPEERGKAMGVYSLGPLLGPALGPIIGGFITqsLGWRWIFWFLAIISGFCLILIFLFL 174
|
|
| 2A0121 |
TIGR00900 |
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds] |
40-348 |
4.77e-03 |
|
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 38.84 E-value: 4.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 40 SAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFI-----ILGTACYLIFFIGILYAQTIFVAYACGFLAGMANSFLDA 114
Cdd:TIGR00900 32 SASVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMigadlIRAVLVAVLPFVALLGGLNIWQVYVLAGILAIAQAFFTP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 115 GTYPSLMEAFPRSPST-ANILIKAFVSGGQFLLPIIISLLVwANMWFGWSFLLAGAIMLINALFLLRCPfPPYPGRILKP 193
Cdd:TIGR00900 112 AYQAMLPDLVPEEQLTqANSLSQAVRSLFYIVGPGIGGLMY-ATLGIKWAIWVDAVGFAISALLIVSVR-IPELAASEIQ 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 194 KISQAPVTGVHHCSLIDLISYTLYGYISMATFY------LISQWLAQYGQFVAGMSYTQSIKLLSIYTCGSLLCVFITAP 267
Cdd:TIGR00900 190 ALSNAVLRDTREGIKFVLKNPLLRTLLLLALLFnlvfapAIVALFPYVQSKYLGRGSTHYGWVLAAFGLGALLGALLLGL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 268 LVRKTIRSTTLLMFYTFISFIALLTVCLHPQAYVVMIFAFVIGFSSAGGVVQIGlTLMAARFPQE-KGKATGIYYSAGSI 346
Cdd:TIGR00900 270 LGRYFKRMALMTGAIFVIGLAILVVGLTPPNFPLFLVLWFAIGVGYGPINVPQG-TLLQRRVPAElLGRVFGAQFSLSHA 348
|
..
gi 446720356 347 AT 348
Cdd:TIGR00900 349 AW 350
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
40-383 |
5.34e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 38.74 E-value: 5.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 40 SAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRR-PFIILGTACYLIFFIGILYAQTIFVAYACGFLAGMAnsfldAGTYP 118
Cdd:cd17490 29 SLSMIGIILGAYGISQMLLRIPLGILSDRIGKRkLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIA-----AATWV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 119 SLM----EAFPRSPSTANILIKAFVSGGQFLLPIIISLLVWANMWFGWSFLLAGAIMLINALFLLRCPFPPYPGRILKPK 194
Cdd:cd17490 104 SFTvlyaSYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTE 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 195 ISQAPVTgvhhCSLIDLISYTLYG----YISMAT-FYLISQWLAQYgqfvaGMSYTQSIKLLSIYTCGSLLCVFITAPLV 269
Cdd:cd17490 184 LKELLSV----LKDKKLLFFSLLAilqqMITFSTtFGFTPLIAKQL-----GASSFQLGLLSIIYLLPNALASLLSGTLF 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 270 RKTIRSTTLLMFYTFISFIALLTVCLHPQAYVVMIFAFVIGFssAGGVVQIGLTLMAARF--PQEKGKATGIYYSAGSIA 347
Cdd:cd17490 255 YKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGF--GTGILFPLLMSLSIEGvpAEQRSTAMGFFQAIYALG 332
|
330 340 350
....*....|....*....|....*....|....*..
gi 446720356 348 TFTIPLITARISE-MSIAHIMWFDTGIAAAGFLLALF 383
Cdd:cd17490 333 MFLGPVLVGIISEaFGLQTGFFVIGVIALLAAILSLA 369
|
|
| MFS_SLC22A17_like |
cd17373 |
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ... |
50-206 |
6.80e-03 |
|
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340931 [Multi-domain] Cd Length: 348 Bit Score: 38.27 E-value: 6.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446720356 50 SLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFIGILYAQTIFVAYACGFLAGMANSFLDAGTYPSLMEAFPRSPS 129
Cdd:cd17373 33 SLLLGLIFGYLILGCIADRFGRRPVLLFSLILILIFGLTVALAVSVTMFSTLRFLEGFCLAGIILTLYLLRLELCDPGKR 112
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446720356 130 TANILIKAFVS-GGQFLLPIIISLLVwanmwfGWSFlLAGAIMLINALFLLRCPFPPYPGRILkpKISQAPVTGVHHC 206
Cdd:cd17373 113 LMITMVASLVAvAGQFLMPGLAALCR------DWRV-LQALIICPFLLMLLYWSIFPKNILIL--GFNSLTGYGIRHC 181
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
31-87 |
7.09e-03 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 38.11 E-value: 7.09e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 446720356 31 SSLEQQWHTSAAGVSIVISSLGIGRLSVLLIAGMLSDRFGRRPFIILGTACYLIFFI 87
Cdd:cd17366 218 SYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAV 274
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
60-108 |
8.30e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 38.21 E-value: 8.30e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 446720356 60 LIAGMLSDRFGRRPFIILGTACYLIFFIGILYAQTIFVAYACGFLAGMA 108
Cdd:COG2270 292 LLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLV 340
|
|
| |
