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Conserved domains on  [gi|446699628|ref|WP_000776974|]
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MULTISPECIES: membrane-bound lytic murein transglycosylase EmtA [Salmonella]

Protein Classification

membrane-bound lytic murein transglycosylase EmtA( domain architecture ID 11487811)

membrane-bound lytic murein transglycosylase EmtA is a murein-degrading enzyme that may play a role in recycling of muropeptides during cell elongation and/or cell division

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
1-203 7.11e-162

membrane-bound lytic murein transglycosylase EmtA;


:

Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 444.41  E-value: 7.11e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446699628   1 MKLRWFAFLVVILAGCSSKQDYRNPPWNAEVPVKRAMQWMPISEKAGAAWGVDPHLITAIIAIESGGNPNAVSKSNAIGL 80
Cdd:PRK15470   1 MKLRWFAFLIVLLAGCSSKHDYTNPPWNAKVPVQRAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446699628  81 MQLKASTSGRDVYRRMGWRGEPTTSELKNPERNISMGAAYLSILENGPLAGIKDPQVMQYALVVSYANGAGALLRTFSSD 160
Cdd:PRK15470  81 MQLKASTSGRDVYRRMGWSGEPTTSELKNPERNISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGALLRTFSSD 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 446699628 161 RKKAIEKINDLDADEFFEHVVDNHPAPQAPRYIWKLQQALDAM 203
Cdd:PRK15470 161 RKKAISKINDLDADEFLEHVARNHPAPQAPRYIYKLEQALDAM 203
 
Name Accession Description Interval E-value
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
1-203 7.11e-162

membrane-bound lytic murein transglycosylase EmtA;


Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 444.41  E-value: 7.11e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446699628   1 MKLRWFAFLVVILAGCSSKQDYRNPPWNAEVPVKRAMQWMPISEKAGAAWGVDPHLITAIIAIESGGNPNAVSKSNAIGL 80
Cdd:PRK15470   1 MKLRWFAFLIVLLAGCSSKHDYTNPPWNAKVPVQRAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446699628  81 MQLKASTSGRDVYRRMGWRGEPTTSELKNPERNISMGAAYLSILENGPLAGIKDPQVMQYALVVSYANGAGALLRTFSSD 160
Cdd:PRK15470  81 MQLKASTSGRDVYRRMGWSGEPTTSELKNPERNISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGALLRTFSSD 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 446699628 161 RKKAIEKINDLDADEFFEHVVDNHPAPQAPRYIWKLQQALDAM 203
Cdd:PRK15470 161 RKKAISKINDLDADEFLEHVARNHPAPQAPRYIYKLEQALDAM 203
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 41-199 9.64e-83

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 242.46  E-value: 9.64e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446699628  41 PISEKAGAAWGVDPHLITAIIAIESGGNPNAVSKSNAIGLMQLKASTSGRDVYRRMGWR-GEPTTSELKNPERNISMGAA 119
Cdd:cd16893    1 PIVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLGGKgGLPSKSYLFDPENNIDIGTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446699628 120 YLSILENGPLAGIKDPQVMQYALVVSYANGAGALLRTFSSDRKKAIEKINDLDADEFFEHVVDNHPAPQAPRYIWKLQQA 199
Cdd:cd16893   81 YLHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTFSSDRKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVLKA 160
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 45-168 4.35e-31

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 109.70  E-value: 4.35e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446699628   45 KAGAAWGVDPHLITAIIAIESGGNPNAVSKSNAIGLMQLKASTSGRDVYrrmgwRGEPTTSELKNPERNISMGAAYLSIL 124
Cdd:pfam01464   3 KAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLGL-----RVNPGVDDLFDPEKNIKAGTKYLKEL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 446699628  125 ENGPLAGIkdpqvmqYALVVSYANGAGALLRTFSSDRKKAIEKI 168
Cdd:pfam01464  78 YKQYGGDL-------WLALAAYNAGPGRVRKWIKNAGAKDKKLL 114
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 23-195 1.97e-30

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 112.01  E-value: 1.97e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446699628  23 RNPPWNAEVPVKRAMQWMPISEKAGAAWGVDPHLITAIIAIESGGNPNAVSKSNAIGLMQLKASTsGRDVYRRMGWRgeP 102
Cdd:COG0741   87 AELLALAALLLRRPLPYLPLIEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPAT-ARRLGLKLGLG--P 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446699628 103 TTSELKNPERNISMGAAYLSILENGPLAGIkdpqvmqYALVVSYANGAGALLRTFSSDRKKAIEKIndldadeffehvvd 182
Cdd:COG0741  164 SPDDLFDPETNIRAGAAYLRELLDRFDGDL-------VLALAAYNAGPGRVRRWLRRNGDRDGEII-------------- 222

                        170
                 ....*....|...
gi 446699628 183 nhPAPQAPRYIWK 195
Cdd:COG0741  223 --PYAETRNYVKK 233
 
Name Accession Description Interval E-value
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
1-203 7.11e-162

membrane-bound lytic murein transglycosylase EmtA;


Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 444.41  E-value: 7.11e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446699628   1 MKLRWFAFLVVILAGCSSKQDYRNPPWNAEVPVKRAMQWMPISEKAGAAWGVDPHLITAIIAIESGGNPNAVSKSNAIGL 80
Cdd:PRK15470   1 MKLRWFAFLIVLLAGCSSKHDYTNPPWNAKVPVQRAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446699628  81 MQLKASTSGRDVYRRMGWRGEPTTSELKNPERNISMGAAYLSILENGPLAGIKDPQVMQYALVVSYANGAGALLRTFSSD 160
Cdd:PRK15470  81 MQLKASTSGRDVYRRMGWSGEPTTSELKNPERNISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGALLRTFSSD 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 446699628 161 RKKAIEKINDLDADEFFEHVVDNHPAPQAPRYIWKLQQALDAM 203
Cdd:PRK15470 161 RKKAISKINDLDADEFLEHVARNHPAPQAPRYIYKLEQALDAM 203
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 41-199 9.64e-83

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 242.46  E-value: 9.64e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446699628  41 PISEKAGAAWGVDPHLITAIIAIESGGNPNAVSKSNAIGLMQLKASTSGRDVYRRMGWR-GEPTTSELKNPERNISMGAA 119
Cdd:cd16893    1 PIVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLGGKgGLPSKSYLFDPENNIDIGTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446699628 120 YLSILENGPLAGIKDPQVMQYALVVSYANGAGALLRTFSSDRKKAIEKINDLDADEFFEHVVDNHPAPQAPRYIWKLQQA 199
Cdd:cd16893   81 YLHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTFSSDRKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVLKA 160
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
34-199 1.20e-57

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 185.25  E-value: 1.20e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446699628  34 KRAMQWMPISEKAGAAWGVDPHLITAIIAIESGGNPNAVSKSNAIGLMQLKASTSGRDVYRRMGWRGEPTTSELKNPERN 113
Cdd:PRK11671 187 KRAHKYLPMVRKASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTAGKDVFRMKGKSGQPSRSYLFDPANN 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446699628 114 ISMGAAYLSILENGPLAGIKDPQVMQYALVVSYANGAGALLRTFSSDRKKAIEKINDLDADEFFEHVVDNHPAPQAPRYI 193
Cdd:PRK11671 267 IDTGTAYLAILQNVYLGGITNPTSRRYAVITAYNGGAGSVLRVFSNDKIQAANIINTMSPGDVYQTLTTRHPSAESRRYL 346


                 ....*.
gi 446699628 194 WKLQQA 199
Cdd:PRK11671 347 YKVNTA 352
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 45-168 4.35e-31

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 109.70  E-value: 4.35e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446699628   45 KAGAAWGVDPHLITAIIAIESGGNPNAVSKSNAIGLMQLKASTSGRDVYrrmgwRGEPTTSELKNPERNISMGAAYLSIL 124
Cdd:pfam01464   3 KAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLGL-----RVNPGVDDLFDPEKNIKAGTKYLKEL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 446699628  125 ENGPLAGIkdpqvmqYALVVSYANGAGALLRTFSSDRKKAIEKI 168
Cdd:pfam01464  78 YKQYGGDL-------WLALAAYNAGPGRVRKWIKNAGAKDKKLL 114
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 23-195 1.97e-30

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 112.01  E-value: 1.97e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446699628  23 RNPPWNAEVPVKRAMQWMPISEKAGAAWGVDPHLITAIIAIESGGNPNAVSKSNAIGLMQLKASTsGRDVYRRMGWRgeP 102
Cdd:COG0741   87 AELLALAALLLRRPLPYLPLIEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPAT-ARRLGLKLGLG--P 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446699628 103 TTSELKNPERNISMGAAYLSILENGPLAGIkdpqvmqYALVVSYANGAGALLRTFSSDRKKAIEKIndldadeffehvvd 182
Cdd:COG0741  164 SPDDLFDPETNIRAGAAYLRELLDRFDGDL-------VLALAAYNAGPGRVRRWLRRNGDRDGEII-------------- 222

                        170
                 ....*....|...
gi 446699628 183 nhPAPQAPRYIWK 195
Cdd:COG0741  223 --PYAETRNYVKK 233
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 44-126 4.22e-22

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 87.57  E-value: 4.22e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446699628  44 EKAGAAWGVDPHLITAIIAIESGGNPNAVSKSNAIGLMQLKASTsGRDVYRRMGWRgEPTTSELKNPERNISMGAAYLSI 123
Cdd:cd16896    9 EKYAKEYGVDPLLVAAVIKVESNFNPNAVSSKGAIGLMQIMPET-AEWIAEKLGLE-DFSEDDLYDPETNIRLGTWYLSY 86


                 ...
gi 446699628 124 LEN 126
Cdd:cd16896   87 LLK 89
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 37-180 2.55e-19

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 80.21  E-value: 2.55e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446699628  37 MQWMPISEKAGAAWGVDPHLITAIIAIESGGNPNAVSKSNAIGLMQLKASTsGRDVYRRMGWRGePTTSELKNPERNISM 116
Cdd:cd13401    4 LPYRDLVERAAKKNGLDPALVYAIIRQESAFDPDAVSPAGALGLMQLMPAT-AKDVAKKLGLPY-YSPRDLFDPEYNIRL 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446699628 117 GAAYLSILE---NGplagikdpqvmQYALVV-SYANGAGALlrtfssdrKKAIEKINDLDADEFFEHV 180
Cdd:cd13401   82 GSAYLAELLdrfDG-----------NPVLALaAYNAGPGRV--------RRWLKRRGDLDPDLWIETI 130
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 54-124 2.07e-16

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 71.48  E-value: 2.07e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446699628  54 PHLITAIIAIESGGNPNAVSKSNAIGLMQLKASTsgrdvYRRMGWRGEpttSELKNPERNISMGAAYLSIL 124
Cdd:cd00254    1 PALVLAVIRVESGFNPRAVSPAGARGLMQLMPGT-----ARDLGRRGV---DDLFDPEENIRAGARYLREL 63
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 44-155 2.47e-15

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 70.26  E-value: 2.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446699628  44 EKAGAAWGVDPHLITAIIAIESGGNPNAVSKSNAIGLMQLKASTSgrdvyRRMGwrgeptTSELKNPERNISMGAAYLSI 123
Cdd:cd13403    2 KKYAEKYGFDWRLLAAQAYQESRFNPNARSPAGARGLMQLMPSTA-----RELG------VNDRLDPEQNIHAGAKYLRY 70

                         90       100       110
                 ....*....|....*....|....*....|..
gi 446699628 124 LENGPLAGIKDPQVMQYALvVSYANGAGALLR 155
Cdd:cd13403   71 LRDRFPPDIDEPDRLKFAL-AAYNAGPGHVRD 101
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 34-179 1.49e-14

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 71.25  E-value: 1.49e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446699628  34 KRAMQWMPISEKAGAAWGVDPHLITAIIAIESGGNPNAVSKSNAIGLMQLKASTSgrdvyRRMGwrgeptTSELKNPERN 113
Cdd:COG4623  259 GRLPPYDPLFEKYAEEYGLDWRLLAALAYQESHWNPRARSPTGARGLMQLMPATA-----KELG------VDDRLDPEQS 327

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446699628 114 ISMGAAYLSILENGPLAGIKDPQVMQYALvVSYANGAGALLRtfssDRKKAieKINDLDADEFFEH 179
Cdd:COG4623  328 IRAGAKYLRWLYDRFPEAIDEPDRWWFAL-AAYNAGPGHVQD----ARRLA--KKQGLDPDRWFDV 386
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 50-122 4.10e-08

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 49.45  E-value: 4.10e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446699628  50 WGVDPHLITAIIAIESGGNPNAVSKSN----AIGLMQLkaSTSGRDVYRRMGWrgePTTSELKNPERNISMGAAYLS 122
Cdd:cd13400    1 YGVPPRLLRAIAKVESGFNPNAINRNKngsyDIGLMQI--NSIWLPELARYGI---TREELLNDPCTNIYVGAWILA 72
PRK10859 PRK10859
membrane-bound lytic murein transglycosylase MltF;
38-154 7.13e-06

membrane-bound lytic murein transglycosylase MltF;


Pssm-ID: 236778 [Multi-domain]  Cd Length: 482  Bit Score: 45.64  E-value: 7.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446699628  38 QWMPISEKAgaAWGVDPHLITAIIAIESGGNPNAVSKSNAIGLMQLKASTSgrdvyRRMGwrgepTTSELkNPERNISMG 117
Cdd:PRK10859 289 KYQPLFEKY--AGELDWRLLAAIAYQESHWNPQATSPTGVRGLMMLTRNTA-----QSMG-----VTDRL-DPEQSIRGG 355

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446699628 118 AAYLS-ILENGPlAGIKDPQVMQYALvVSYANGAGALL 154
Cdd:PRK10859 356 ARYLQdLMERLP-ESIPEPERIWFAL-AAYNIGYGHML 391
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 50-87 1.34e-05

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 42.68  E-value: 1.34e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 446699628  50 WGVDPHLITAIIAIESGGNPNAV-SKSNAIGLMQLKAST 87
Cdd:cd13399    1 YGVPPGILAAILGVESGFGPNAGgSPAGAQGIAQFMPST 39
PRK11619 PRK11619
lytic murein transglycosylase; Provisional
 59-121 6.02e-05

lytic murein transglycosylase; Provisional


Pssm-ID: 183236 [Multi-domain]  Cd Length: 644  Bit Score: 43.13  E-value: 6.02e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446699628  59 AIIAIESGGNPNAVSKSNAIGLMQLKASTSGRDVyRRMGWRGEPTTSELKNPERNISMGAAYL 121
Cdd:PRK11619 499 AIARQESAWNPKARSPVGASGLMQIMPGTATHTV-KMFSIPGYSSSSQLLDPETNINIGTSYL 560
MltD-like cd16894
Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases ...
 63-98 9.30e-04

Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases (LT) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc). Membrane-bound lytic murein transglycosylase D protein (MltD) family members may have one or more small LysM domains, which may contribute to peptidoglycan binding. Unlike the similar "goose-type" lysozymes, LTs also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381615 [Multi-domain]  Cd Length: 129  Bit Score: 37.88  E-value: 9.30e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 446699628  63 IESGGNPNAVSKSNAIGLMQLKASTsGRDVYRRMGW 98
Cdd:cd16894   16 VESGFNPDAVSSAGAAGLWQFMPAT-AREYGLRVDS 50
PRK15328 PRK15328
type III secretion system invasion protein IagB;
27-122 1.27e-03

type III secretion system invasion protein IagB;


Pssm-ID: 185228 [Multi-domain]  Cd Length: 160  Bit Score: 37.92  E-value: 1.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446699628  27 WNAEVPVKRAMQWmpisEKAGAAWGVDPHLITAIIAIESGGNPNAVSK----SNAIGLMQLKASTSGRdvYRRMGwrgep 102
Cdd:PRK15328  10 WLLSINTAWADCW----LQAEKMFNIESELLYAIAQQESAMKPGAIGHnrdgSTDLGLMQINSFHMKR--LKKMG----- 78

                         90       100
                 ....*....|....*....|...
gi 446699628 103 tTSE---LKNPERNISMGAAYLS 122
Cdd:PRK15328  79 -ISEkqlLQDPCISVIVGASILS 100
LT_TF-like cd13402
lytic transglycosylase-like domain of tail fiber-like proteins and similar domains; These tail ...
 55-87 1.89e-03

lytic transglycosylase-like domain of tail fiber-like proteins and similar domains; These tail fiber-like proteins are multi-domain proteins that include a lytic transglycosylase (LT) domain. Members of the LT family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, and the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL). LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381605 [Multi-domain]  Cd Length: 117  Bit Score: 36.79  E-value: 1.89e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 446699628  55 HLITAIIAIESGGNPNAVSK--SNAI------GLMQLKAST 87
Cdd:cd13402    2 NALLRQIQTESGGNPNAINNwdSNAKaghpskGLMQVIPPT 42
PHA00368 PHA00368
internal virion protein D
 42-124 2.20e-03

internal virion protein D


Pssm-ID: 222785 [Multi-domain]  Cd Length: 1315  Bit Score: 38.61  E-value: 2.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446699628   42 ISEKAGAAWGVDPHLITAIIAIESGGNPNAVSKSNAIGLMQLkastsGRDVYRRMGWRGEPttSELKNPERNISMGAAYL 121
Cdd:PHA00368   14 LFQKAADAHGVSYDLLRKVGWDESRFNPTAKSPTGPKGLMQF-----TKATAKALGLIVDD--DDRLDPELAIDAGARYL 86


                  ...
gi 446699628  122 SIL 124
Cdd:PHA00368   87 ADL 89
GEWL cd01021
Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; ...
 29-82 2.21e-03

Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; GEWL) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc). Mammals have two lysozymes. This family corresponds to human and mouse lysozyme G-like protein 2.


Pssm-ID: 381601 [Multi-domain]  Cd Length: 174  Bit Score: 37.19  E-value: 2.21e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446699628  29 AEVPVKRAMQWMPISEKAGAAWGVDPHLITAIIAIESGGNpNAVSK------SNAIGLMQ 82
Cdd:cd01021   27 AETDLNRLNKYKDCIKQVGKKLCIDPALIAAIISRESRAG-AALDKngwgdhGNGFGLMQ 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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