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Conserved domains on  [gi|446694089|ref|WP_000771435|]
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MULTISPECIES: curli major subunit CsgA [Enterobacteriaceae]

Protein Classification

curli major subunit CsgA( domain architecture ID 10793335)

curli major subunit CsgA is a component of curlin, which is the structural subunit of the curli fimbriae.

Gene Ontology:  GO:0042802|GO:0009289

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
csgA PRK10051
major curlin subunit CsgA;
1-151 2.29e-71

major curlin subunit CsgA;


:

Pssm-ID: 182211 [Multi-domain]  Cd Length: 151  Bit Score: 211.25  E-value: 2.29e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446694089   1 MKLLKVAAIAAIVFSGSALAGVVPQYGGGGNHGGGGNNSGPNSELNIYQYGGGNSALALQADARNSDLTITQHGGGNGAD 80
Cdd:PRK10051   1 MKLLKVAAIAAIVVSGSALAGVVPQYGGGGNHGGGGNNSGPNSTLNIYQYGGGNSALALQSDARNSDLTITQHGGGNGAD 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446694089  81 VGQGSDDSSIDLTQRGFGNSATLDQWNGKDSTMTVKQFGGGNGAAVDQTASNSSVNVTQVGFGNNATAHQY 151
Cdd:PRK10051  81 VGQGSDDSSIDLTQNGFGNSATLDQWNGKNSDMTVKQFGGGNGAAVDQTASNSSVNVTQVGFGNNATAHQY 151
 
Name Accession Description Interval E-value
csgA PRK10051
major curlin subunit CsgA;
1-151 2.29e-71

major curlin subunit CsgA;


Pssm-ID: 182211 [Multi-domain]  Cd Length: 151  Bit Score: 211.25  E-value: 2.29e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446694089   1 MKLLKVAAIAAIVFSGSALAGVVPQYGGGGNHGGGGNNSGPNSELNIYQYGGGNSALALQADARNSDLTITQHGGGNGAD 80
Cdd:PRK10051   1 MKLLKVAAIAAIVVSGSALAGVVPQYGGGGNHGGGGNNSGPNSTLNIYQYGGGNSALALQSDARNSDLTITQHGGGNGAD 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446694089  81 VGQGSDDSSIDLTQRGFGNSATLDQWNGKDSTMTVKQFGGGNGAAVDQTASNSSVNVTQVGFGNNATAHQY 151
Cdd:PRK10051  81 VGQGSDDSSIDLTQNGFGNSATLDQWNGKNSDMTVKQFGGGNGAAVDQTASNSSVNVTQVGFGNNATAHQY 151
Curlin_rpt pfam07012
Curlin associated repeat; This family consists of several bacterial repeats of around 30 ...
 86-119 1.40e-03

Curlin associated repeat; This family consists of several bacterial repeats of around 30 residues in length. These repeats are often found in multiple copies in the curlin proteins CsgA and CsgB. Curli fibres are thin aggregative surface fibres, connected with adhesion, which bind laminin, fibronectin, plasminogen, human contact phase proteins, and major histocompatibility complex (MHC) class I molecules. Curli fibres are coded for by the csg gene cluster, which is comprised of two divergently transcribed operons. One operon encodes the csgB, csgA, and csgC genes, while the other encodes csgD, csgE, csgF, and csgG. The assembly of the fibres is unique and involves extracellular self-assembly of the curlin subunit (CsgA), dependent on a specific nucleator protein (CsgB). CsgD is a transcriptional activator essential for expression of the two curli fibre operons, and CsgG is an outer membrane lipoprotein involved in extracellular stabilization of CsgA and CsgB.


Pssm-ID: 429248 [Multi-domain]  Cd Length: 34  Bit Score: 34.36  E-value: 1.40e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 446694089   86 DDSSIDLTQRGFGNSATLDQwNGKDSTMTVKQFG 119
Cdd:pfam07012   2 DDNTADITQSGDNNSAYVGQ-SGSNNDATVTQTG 34
 
Name Accession Description Interval E-value
csgA PRK10051
major curlin subunit CsgA;
1-151 2.29e-71

major curlin subunit CsgA;


Pssm-ID: 182211 [Multi-domain]  Cd Length: 151  Bit Score: 211.25  E-value: 2.29e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446694089   1 MKLLKVAAIAAIVFSGSALAGVVPQYGGGGNHGGGGNNSGPNSELNIYQYGGGNSALALQADARNSDLTITQHGGGNGAD 80
Cdd:PRK10051   1 MKLLKVAAIAAIVVSGSALAGVVPQYGGGGNHGGGGNNSGPNSTLNIYQYGGGNSALALQSDARNSDLTITQHGGGNGAD 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446694089  81 VGQGSDDSSIDLTQRGFGNSATLDQWNGKDSTMTVKQFGGGNGAAVDQTASNSSVNVTQVGFGNNATAHQY 151
Cdd:PRK10051  81 VGQGSDDSSIDLTQNGFGNSATLDQWNGKNSDMTVKQFGGGNGAAVDQTASNSSVNVTQVGFGNNATAHQY 151
csgB PRK10101
curlin minor subunit CsgB; Provisional
 65-151 1.01e-04

curlin minor subunit CsgB; Provisional


Pssm-ID: 182242 [Multi-domain]  Cd Length: 151  Bit Score: 40.23  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446694089  65 NSDLTITQHGGGNGADVGQGSDDSSIDLTQRGFGNSATLDQwNGKDSTMTVKQFGGGNGAAVDQTASNSSVNVTQVGFGN 144
Cdd:PRK10101  44 NQAAIIGQAGTNNSAQVRQGGSKLLAVVSQEGSSNRAKIDQ-TGDYNLAYIDQTGSANDASISQGAYGNTAMIIQKGSGN 122


                 ....*..
gi 446694089 145 NATAHQY 151
Cdd:PRK10101 123 KANITQY 129
csgB PRK10101
curlin minor subunit CsgB; Provisional
 47-139 4.53e-04

curlin minor subunit CsgB; Provisional


Pssm-ID: 182242 [Multi-domain]  Cd Length: 151  Bit Score: 38.30  E-value: 4.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446694089  47 IYQYGGGNSALALQaDARNSDLTITQHGGGNGADVGQGSDDSSIDLTQRGFGNSATLDQWNGKDSTMTVKQfGGGNGAAV 126
Cdd:PRK10101  49 IGQAGTNNSAQVRQ-GGSKLLAVVSQEGSSNRAKIDQTGDYNLAYIDQTGSANDASISQGAYGNTAMIIQK-GSGNKANI 126

                         90
                 ....*....|...
gi 446694089 127 DQTASNSSVNVTQ 139
Cdd:PRK10101 127 TQYGTQKTAVVVQ 139
Curlin_rpt pfam07012
Curlin associated repeat; This family consists of several bacterial repeats of around 30 ...
 86-119 1.40e-03

Curlin associated repeat; This family consists of several bacterial repeats of around 30 residues in length. These repeats are often found in multiple copies in the curlin proteins CsgA and CsgB. Curli fibres are thin aggregative surface fibres, connected with adhesion, which bind laminin, fibronectin, plasminogen, human contact phase proteins, and major histocompatibility complex (MHC) class I molecules. Curli fibres are coded for by the csg gene cluster, which is comprised of two divergently transcribed operons. One operon encodes the csgB, csgA, and csgC genes, while the other encodes csgD, csgE, csgF, and csgG. The assembly of the fibres is unique and involves extracellular self-assembly of the curlin subunit (CsgA), dependent on a specific nucleator protein (CsgB). CsgD is a transcriptional activator essential for expression of the two curli fibre operons, and CsgG is an outer membrane lipoprotein involved in extracellular stabilization of CsgA and CsgB.


Pssm-ID: 429248 [Multi-domain]  Cd Length: 34  Bit Score: 34.36  E-value: 1.40e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 446694089   86 DDSSIDLTQRGFGNSATLDQwNGKDSTMTVKQFG 119
Cdd:pfam07012   2 DDNTADITQSGDNNSAYVGQ-SGSNNDATVTQTG 34
Curlin_rpt pfam07012
Curlin associated repeat; This family consists of several bacterial repeats of around 30 ...
 108-141 3.17e-03

Curlin associated repeat; This family consists of several bacterial repeats of around 30 residues in length. These repeats are often found in multiple copies in the curlin proteins CsgA and CsgB. Curli fibres are thin aggregative surface fibres, connected with adhesion, which bind laminin, fibronectin, plasminogen, human contact phase proteins, and major histocompatibility complex (MHC) class I molecules. Curli fibres are coded for by the csg gene cluster, which is comprised of two divergently transcribed operons. One operon encodes the csgB, csgA, and csgC genes, while the other encodes csgD, csgE, csgF, and csgG. The assembly of the fibres is unique and involves extracellular self-assembly of the curlin subunit (CsgA), dependent on a specific nucleator protein (CsgB). CsgD is a transcriptional activator essential for expression of the two curli fibre operons, and CsgG is an outer membrane lipoprotein involved in extracellular stabilization of CsgA and CsgB.


Pssm-ID: 429248 [Multi-domain]  Cd Length: 34  Bit Score: 33.59  E-value: 3.17e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 446694089  108 GKDSTMTVKQFGGGNGAAVDQTASNSSVNVTQVG 141
Cdd:pfam07012   1 GDDNTADITQSGDNNSAYVGQSGSNNDATVTQTG 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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