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Conserved domains on  [gi|446675452|ref|WP_000752798|]
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MULTISPECIES: type I-E CRISPR-associated protein Cse2/CasB [Enterobacteriaceae]

Protein Classification

type I-E CRISPR-associated protein Cse2/CasB( domain architecture ID 10176646)

type I-E CRISPR-associated protein Cse2/CasB is an essential protein component in Type I-E Cascade.

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cse2_I-E cd09670
CRISPR/Cas system-associated protein Cse2; CRISPR (Clustered Regularly Interspaced Short ...
 9-155 1.89e-35

CRISPR/Cas system-associated protein Cse2; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Small alpha-helical protein; also known as Cse2/CasB/YgcK family; specific gene for I-E subtype;


:

Pssm-ID: 187801  Cd Length: 152  Bit Score: 120.64  E-value: 1.89e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446675452   9 ALYRAWQQLDN--GACAQIRRVSEPdELRDIPAFYRLVQPFGW-ENPRHQQALLRMVFCLSAGKNVIRHQdkkpeqtTGI 85
Cdd:cd09670    1 ALYEALERLDGdrGARAALRRGLPP-ELADLPAGFRFLWQYLTgDNPETERRAYLMVAALIALKDQSRHR-------EGI 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446675452  86 SLGRALANSGR----INERRIFQLIRADRTADMVQLRRLLTHAEP---VLDWPLMARMLTWWG---KRERQQLLEDFVLT 155
Cdd:cd09670   73 SLGRALAELGRsssdVSERRFLALLAADRPELLRRLRRLVRLLRSkaiSVDYAQLARDLLRWNhpsERVRRRWARDYYRA 152
 
Name Accession Description Interval E-value
Cse2_I-E cd09670
CRISPR/Cas system-associated protein Cse2; CRISPR (Clustered Regularly Interspaced Short ...
 9-155 1.89e-35

CRISPR/Cas system-associated protein Cse2; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Small alpha-helical protein; also known as Cse2/CasB/YgcK family; specific gene for I-E subtype;


Pssm-ID: 187801  Cd Length: 152  Bit Score: 120.64  E-value: 1.89e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446675452   9 ALYRAWQQLDN--GACAQIRRVSEPdELRDIPAFYRLVQPFGW-ENPRHQQALLRMVFCLSAGKNVIRHQdkkpeqtTGI 85
Cdd:cd09670    1 ALYEALERLDGdrGARAALRRGLPP-ELADLPAGFRFLWQYLTgDNPETERRAYLMVAALIALKDQSRHR-------EGI 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446675452  86 SLGRALANSGR----INERRIFQLIRADRTADMVQLRRLLTHAEP---VLDWPLMARMLTWWG---KRERQQLLEDFVLT 155
Cdd:cd09670   73 SLGRALAELGRsssdVSERRFLALLAADRPELLRRLRRLVRLLRSkaiSVDYAQLARDLLRWNhpsERVRRRWARDYYRA 152
casB_cse2 TIGR02548
CRISPR type I-E/ECOLI-associated protein CasB/Cse2; CRISPR is a term for Clustered, Regularly ...
 10-155 3.52e-30

CRISPR type I-E/ECOLI-associated protein CasB/Cse2; CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This model family is found in Ecoli subtype CRISPR/Cas regions of many bacteria, most of which are mesophiles, and not in Archaea. It was designated Cse2 originally, and renamed CasB based on its characterization in the CASCADE complex.


Pssm-ID: 274193  Cd Length: 160  Bit Score: 107.16  E-value: 3.52e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446675452   10 LYRAWQQLDNG-------ACAQIRRVSEPDELRDIPAFYRLVQPFGWENPRHQQALLRMVFCLSAGknvirHQDKKPEQT 82
Cdd:TIGR02548   1 LYEALERLDEGdpgaraaLRAGLRRCAGPDPLLLSFVFPRLLKGDQWETPERRAPYLVAALAAAAG-----QSLKVGSHT 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446675452   83 TGISLGRALANSGRI-----NERRIFQLIRAD-RTADMVQLRRLLTHAEPV---LDWPLMARMLTWWGKRE---RQQLLE 150
Cdd:TIGR02548  76 PGISLARALAEKGRSlasnaSERRFRALLEADaRDELLRRLRRLLSLLKSLaisVDYAQLARDLLRWNDPSqrvRRRWAR 155


                  ....*
gi 446675452  151 DFVLT 155
Cdd:TIGR02548 156 DYYRA 160
Cse2gr11 COG5949
CRISPR-Cas system type I-E effector complex small subunit Cse2 [Defense mechanisms]; ...
 13-160 3.59e-19

CRISPR-Cas system type I-E effector complex small subunit Cse2 [Defense mechanisms]; CRISPR-Cas system type I-E effector complex small subunit Cse2 is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 444647  Cd Length: 179  Bit Score: 79.34  E-value: 3.59e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446675452  13 AWQQLDNGACAQIRRVSEPDELRDIPAFYRLVQPFGW-ENPRHQQALLRMVFCLSagknviRHQDKKPEQTTGISLGRAL 91
Cdd:COG5949   24 RDRALDRGDRARLRRALGPEPGALPPAWPRLARFLPGdEPPREERALALVAALLA------LHKQSDPGRSLGRALARLR 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446675452  92 A-NSGRINERRIFQLIRADRTADMV-QLRRLLTHAEP---VLDWPLMARMLTWWG----KRERQQLLEDFVLTTNKNA 160
Cdd:COG5949   98 GgDRPGVSELRFRRLLAADTPDELLrHLRRLVRLLRSkeiPVDYARLADDLLYWQdepaDRVRRRWARDYYRAAAPEE 175
CRISPR_Cse2 pfam09485
CRISPR-associated protein Cse2 (CRISPR_cse2); Clusters of short DNA repeats with ...
 23-148 1.05e-04

CRISPR-associated protein Cse2 (CRISPR_cse2); Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family of proteins, represented by CT1973 from Chlorobaculum tepidum, is encoded by genes found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse2.


Pssm-ID: 462815  Cd Length: 145  Bit Score: 40.04  E-value: 1.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446675452   23 AQIRRvSEPDELRDIPAFYRLVQPF--GWENPRHQQALLRMVFCLSAGKNVIRHQDKKPEQTTGISLGRALANSGRIN-- 98
Cdd:pfam09485   3 AALRR-GLGKEPGEAPLLWPYLLRFlgPEGEPTPEERAAFAAAALYALHQQSRRDMHQDGRSLGAALGRLRAADESRPks 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 446675452   99 -ERRIFQLIRADRTADMV-QLRRLLT---HAEPVLDWPLMARMLTWWGKRERQQL 148
Cdd:pfam09485  82 sERRFQALLTADTPDELLrHLRRLVAllrSKEIPLDYARLADDLLAWQDEPRRRV 136
 
Name Accession Description Interval E-value
Cse2_I-E cd09670
CRISPR/Cas system-associated protein Cse2; CRISPR (Clustered Regularly Interspaced Short ...
 9-155 1.89e-35

CRISPR/Cas system-associated protein Cse2; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Small alpha-helical protein; also known as Cse2/CasB/YgcK family; specific gene for I-E subtype;


Pssm-ID: 187801  Cd Length: 152  Bit Score: 120.64  E-value: 1.89e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446675452   9 ALYRAWQQLDN--GACAQIRRVSEPdELRDIPAFYRLVQPFGW-ENPRHQQALLRMVFCLSAGKNVIRHQdkkpeqtTGI 85
Cdd:cd09670    1 ALYEALERLDGdrGARAALRRGLPP-ELADLPAGFRFLWQYLTgDNPETERRAYLMVAALIALKDQSRHR-------EGI 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446675452  86 SLGRALANSGR----INERRIFQLIRADRTADMVQLRRLLTHAEP---VLDWPLMARMLTWWG---KRERQQLLEDFVLT 155
Cdd:cd09670   73 SLGRALAELGRsssdVSERRFLALLAADRPELLRRLRRLVRLLRSkaiSVDYAQLARDLLRWNhpsERVRRRWARDYYRA 152
casB_cse2 TIGR02548
CRISPR type I-E/ECOLI-associated protein CasB/Cse2; CRISPR is a term for Clustered, Regularly ...
 10-155 3.52e-30

CRISPR type I-E/ECOLI-associated protein CasB/Cse2; CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This model family is found in Ecoli subtype CRISPR/Cas regions of many bacteria, most of which are mesophiles, and not in Archaea. It was designated Cse2 originally, and renamed CasB based on its characterization in the CASCADE complex.


Pssm-ID: 274193  Cd Length: 160  Bit Score: 107.16  E-value: 3.52e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446675452   10 LYRAWQQLDNG-------ACAQIRRVSEPDELRDIPAFYRLVQPFGWENPRHQQALLRMVFCLSAGknvirHQDKKPEQT 82
Cdd:TIGR02548   1 LYEALERLDEGdpgaraaLRAGLRRCAGPDPLLLSFVFPRLLKGDQWETPERRAPYLVAALAAAAG-----QSLKVGSHT 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446675452   83 TGISLGRALANSGRI-----NERRIFQLIRAD-RTADMVQLRRLLTHAEPV---LDWPLMARMLTWWGKRE---RQQLLE 150
Cdd:TIGR02548  76 PGISLARALAEKGRSlasnaSERRFRALLEADaRDELLRRLRRLLSLLKSLaisVDYAQLARDLLRWNDPSqrvRRRWAR 155


                  ....*
gi 446675452  151 DFVLT 155
Cdd:TIGR02548 156 DYYRA 160
Cse2_I-E cd09731
CRISPR/Cas system-associated protein Cse2; CRISPR (Clustered Regularly Interspaced Short ...
 19-152 1.45e-20

CRISPR/Cas system-associated protein Cse2; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Small alpha-helical protein; also known as Cse2/CasB/YgcK family; specific gene for I-E subtype;


Pssm-ID: 187862  Cd Length: 141  Bit Score: 82.00  E-value: 1.45e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446675452  19 NGACAQIRRVSEPDELRDIPAFYRLVQPFGWE-NPRHQQALLRMVFCLSAgknvirHQdkKPEQTTGISLGRALANSGR- 96
Cdd:cd09731    1 RGDRAALRRALGPDDVLAVPAFWRLLLSLLPDeATRWERAAYALVALLAA------HQ--KSDRKPGISLGAALARLREg 72

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446675452  97 ----INERRIFQLIRADR-TADMVQLRRLLTHAEPV---LDWPLMARMLTWWG---KRERQQLLEDF 152
Cdd:cd09731   73 sgsdVSERRFRQLLRADTpDELLRRLRRLVRLLKSKgvpVDYGQLARDLLYWNhedDRVRRRWARDY 139
Cse2gr11 COG5949
CRISPR-Cas system type I-E effector complex small subunit Cse2 [Defense mechanisms]; ...
 13-160 3.59e-19

CRISPR-Cas system type I-E effector complex small subunit Cse2 [Defense mechanisms]; CRISPR-Cas system type I-E effector complex small subunit Cse2 is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 444647  Cd Length: 179  Bit Score: 79.34  E-value: 3.59e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446675452  13 AWQQLDNGACAQIRRVSEPDELRDIPAFYRLVQPFGW-ENPRHQQALLRMVFCLSagknviRHQDKKPEQTTGISLGRAL 91
Cdd:COG5949   24 RDRALDRGDRARLRRALGPEPGALPPAWPRLARFLPGdEPPREERALALVAALLA------LHKQSDPGRSLGRALARLR 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446675452  92 A-NSGRINERRIFQLIRADRTADMV-QLRRLLTHAEP---VLDWPLMARMLTWWG----KRERQQLLEDFVLTTNKNA 160
Cdd:COG5949   98 GgDRPGVSELRFRRLLAADTPDELLrHLRRLVRLLRSkeiPVDYARLADDLLYWQdepaDRVRRRWARDYYRAAAPEE 175
CRISPR_Cse2 pfam09485
CRISPR-associated protein Cse2 (CRISPR_cse2); Clusters of short DNA repeats with ...
 23-148 1.05e-04

CRISPR-associated protein Cse2 (CRISPR_cse2); Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family of proteins, represented by CT1973 from Chlorobaculum tepidum, is encoded by genes found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse2.


Pssm-ID: 462815  Cd Length: 145  Bit Score: 40.04  E-value: 1.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446675452   23 AQIRRvSEPDELRDIPAFYRLVQPF--GWENPRHQQALLRMVFCLSAGKNVIRHQDKKPEQTTGISLGRALANSGRIN-- 98
Cdd:pfam09485   3 AALRR-GLGKEPGEAPLLWPYLLRFlgPEGEPTPEERAAFAAAALYALHQQSRRDMHQDGRSLGAALGRLRAADESRPks 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 446675452   99 -ERRIFQLIRADRTADMV-QLRRLLT---HAEPVLDWPLMARMLTWWGKRERQQL 148
Cdd:pfam09485  82 sERRFQALLTADTPDELLrHLRRLVAllrSKEIPLDYARLADDLLAWQDEPRRRV 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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