NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446657976|ref|WP_000735322|]
View 

outer membrane channel protein TolC [Escherichia coli]

Protein Classification

outer membrane channel protein TolC( domain architecture ID 11484192)

outer membrane channel protein TolC is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC, and MacAB-TolC

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
tolC PRK09465
outer membrane channel protein; Reviewed
1-451 0e+00

outer membrane channel protein; Reviewed


:

Pssm-ID: 236529 [Multi-domain]  Cd Length: 446  Bit Score: 798.38  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976   1 MKKLLPILIGLSLYGFSSLSQAENLMQVYQQARLSNPELRKSAADRDAAFEKINEARSPLLPQLGLGADYTYSNGYRDAN 80
Cdd:PRK09465   1 MKKLLPLLIGLSLAGFSSASQAEDLLQVYQQARLSNPELLKAAADRDAAFEKINEARSPLLPQLGLGAGYTYSNGYRDAN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976  81 GINSNATSASLQLTQSIFDMSKWRALTLQEKAAGIQDVTYQTDQQTLILNTATAYFNVLNAIDVLSYTQAQKEAIYRQLD 160
Cdd:PRK09465  81 GIDSNGTSASLQLTQTIFDMSKWRALTLAEKAAGIADVTYQTAQQTLILRTATAYFNVLRAIDNLSFTEAEKRAIYRQLD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976 161 QTTQRFNVGLVAITDVQNARAQYDTVLANEVTARNNLDNAVEQLRQITGNYYPELAALNVENFKTDKPQPVNALLKEAEK 240
Cdd:PRK09465 161 QTTQRFNVGLVAITDVQNAQAQYDTVLANEVLARNNLDNAYEALRQITGNYYPELAVLNTERFSTPKPQSVNALLKEAEK 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976 241 RNLSLLQARLSQDLAREQIRQAQDGHLPTLDLTASTGISDTSYSgsktrGAAGTQYDDSNMGQNKVGLSFSLPIYQGGMV 320
Cdd:PRK09465 241 RNLSLLSARLSQDLAREQIRLAQAGHMPTLDLTASYGISDTSYS-----GANGTQYDDSDMGQNKVGLNLSLPLYSGGAV 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976 321 NSQVKQAQYNFVGASEQLESAHRSVVQTVRSSFNNINASISSINAYKQAVVSAQSSLDAMEAGYSVGTRTIVDVLDATTT 400
Cdd:PRK09465 316 NSQVKQAQYNFVGASEQLESAHRSVVQTVRSSFNNINASISSINAYEQAVVSAQSSLDATEAGYEVGTRTIVDVLDATTT 395
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446657976 401 LYNAKQELANARYNYLINQLNIKSALGTLNEQDLLALNNALSKPVSTNPEN 451
Cdd:PRK09465 396 LYDAKQQLSNARYNYLINQLNLKQALGTLNEQDLLALNNGLGKPVSTSPEN 446
 
Name Accession Description Interval E-value
tolC PRK09465
outer membrane channel protein; Reviewed
1-451 0e+00

outer membrane channel protein; Reviewed


Pssm-ID: 236529 [Multi-domain]  Cd Length: 446  Bit Score: 798.38  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976   1 MKKLLPILIGLSLYGFSSLSQAENLMQVYQQARLSNPELRKSAADRDAAFEKINEARSPLLPQLGLGADYTYSNGYRDAN 80
Cdd:PRK09465   1 MKKLLPLLIGLSLAGFSSASQAEDLLQVYQQARLSNPELLKAAADRDAAFEKINEARSPLLPQLGLGAGYTYSNGYRDAN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976  81 GINSNATSASLQLTQSIFDMSKWRALTLQEKAAGIQDVTYQTDQQTLILNTATAYFNVLNAIDVLSYTQAQKEAIYRQLD 160
Cdd:PRK09465  81 GIDSNGTSASLQLTQTIFDMSKWRALTLAEKAAGIADVTYQTAQQTLILRTATAYFNVLRAIDNLSFTEAEKRAIYRQLD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976 161 QTTQRFNVGLVAITDVQNARAQYDTVLANEVTARNNLDNAVEQLRQITGNYYPELAALNVENFKTDKPQPVNALLKEAEK 240
Cdd:PRK09465 161 QTTQRFNVGLVAITDVQNAQAQYDTVLANEVLARNNLDNAYEALRQITGNYYPELAVLNTERFSTPKPQSVNALLKEAEK 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976 241 RNLSLLQARLSQDLAREQIRQAQDGHLPTLDLTASTGISDTSYSgsktrGAAGTQYDDSNMGQNKVGLSFSLPIYQGGMV 320
Cdd:PRK09465 241 RNLSLLSARLSQDLAREQIRLAQAGHMPTLDLTASYGISDTSYS-----GANGTQYDDSDMGQNKVGLNLSLPLYSGGAV 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976 321 NSQVKQAQYNFVGASEQLESAHRSVVQTVRSSFNNINASISSINAYKQAVVSAQSSLDAMEAGYSVGTRTIVDVLDATTT 400
Cdd:PRK09465 316 NSQVKQAQYNFVGASEQLESAHRSVVQTVRSSFNNINASISSINAYEQAVVSAQSSLDATEAGYEVGTRTIVDVLDATTT 395
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446657976 401 LYNAKQELANARYNYLINQLNIKSALGTLNEQDLLALNNALSKPVSTNPEN 451
Cdd:PRK09465 396 LYDAKQQLSNARYNYLINQLNLKQALGTLNEQDLLALNNGLGKPVSTSPEN 446
type_I_sec_TolC TIGR01844
type I secretion outer membrane protein, TolC family; Members of this model are outer membrane ...
21-443 2.98e-146

type I secretion outer membrane protein, TolC family; Members of this model are outer membrane proteins from the TolC subfamily within the RND (Resistance-Nodulation-cell Division) efflux systems. These proteins, unlike the NodT subfamily, appear not to be lipoproteins. All are believed to participate in type I protein secretion, an ABC transporter system for protein secretion without cleavage of a signal sequence, although they may, like TolC, participate also in the efflux of smaller molecules as well. This family includes the well-documented examples TolC (E. coli), PrtF (Erwinia), and AprF (Pseudomonas aeruginosa). [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Porins]


Pssm-ID: 273829 [Multi-domain]  Cd Length: 415  Bit Score: 424.86  E-value: 2.98e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976   21 QAENLMQVYQQARLSNPELRKSAADRDAAFEKINEARSPLLPQLGLGADYTYSNGYRD-ANGINS--NATSASLQLTQSI 97
Cdd:TIGR01844   1 AALTLLDAVLLALANNPELRAARAQRDAGEEQVAQARAALLPQLGLTANYGYSNTYPTeSRGRNTdlNSGSSTLTLSQPL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976   98 FD-MSKWRALTLQEKAAGIQDVTYQTDQQTLILNTATAYFNVLNAIDVLSYTQAQKEAIYRQLDQTTQRFNVGLVAITDV 176
Cdd:TIGR01844  81 FDgGSTWNAVRAAEAAALAARETLRATAQDLILRTAEAYMEVLRAQEILALAEANLAALKEQLDLARARFDVGLGTRTDV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976  177 QNARAQYDTVLANEVTARNNLDNAVEQLRQITGNyyPELAALNVENFKTDKPQPVNALLKEAEKRNLSLLQARLSQDLAR 256
Cdd:TIGR01844 161 LQAEARYASARAQLIQAQNNLDDAKAQLRRLVGQ--PELAPLAVPSFPAELPEPLDQLLEIAEASNPLLLAAQAAVDAAR 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976  257 EQIRQAQDGHLPTLDLTASTGISDTSYSGSKTrgaagtqyddSNMGQNKVGLSFSLPIYQGGMVNSQVKQAQYNFVGASE 336
Cdd:TIGR01844 239 YQVEQARAGHLPTLSLTASTGNSDTSSGGSGN----------SDSDTYSVGLNVSIPLYQGGATSAQVRQAAHQLNQSRS 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976  337 QLESAHRSVVQTVRSSFNNINASISSINAYKQAVVSAQSSLDAMEAGYSVGTRTIVDVLDATTTLYNAKQELANARYNYL 416
Cdd:TIGR01844 309 TLESQKRTVRQQVRNAWSNLNAAAASVQAYEQQVASAQKALDAYRQEYQVGTRTLLDVLNAEQELYQARQELANARYDYL 388
                         410       420
                  ....*....|....*....|....*..
gi 446657976  417 INQLNIKSALGTLNEQDLLALNNALSK 443
Cdd:TIGR01844 389 QAQLNLLSATGTLNEADLLLQNAALSK 415
TolC COG1538
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];
24-431 2.70e-63

Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441147 [Multi-domain]  Cd Length: 367  Bit Score: 209.89  E-value: 2.70e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976  24 NLMQVYQQARLSNPELRKSAADRDAAFEKINEARSPLLPQlglgadytysngyrdanginsnatsaslqltQSIFDMSKW 103
Cdd:COG1538    1 TLDELIERALANNPDLRAARARVEAARAQLRQARAGLLPS-------------------------------QELDLGGKR 49
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976 104 RALTLQEKA-AGIQDVTYQTDQQTLILNTATAYFNVLNAIDVLSYTQAQKEAIYRQLDQTTQRFNVGLVAITDVQNARAQ 182
Cdd:COG1538   50 RARIEAAKAqAEAAEADLRAARLDLAAEVAQAYFDLLAAQEQLALAEENLALAEELLELARARYEAGLASRLDVLQAEAQ 129
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976 183 YDTVLANEVTARNNLDNAVEQLRQITGNYYPELAALNVENFKTDK-PQPVNALLKEAEKRNLSLLQARLSQDLAREQIRQ 261
Cdd:COG1538  130 LAQARAQLAQAEAQLAQARNALALLLGLPPPAPLDLPDPLPPLPPlPPSLPGLPSEALERRPDLRAAEAQLEAAEAEIGV 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976 262 AQDGHLPTLDLTASTGISDTSYSGSKTRGAAGtqyddsnmgqnkVGLSFSLPIYQGGMVNSQVKQAQYNFVGASEQLESA 341
Cdd:COG1538  210 ARAAFLPSLSLSASYGYSSSDDLFSGGSDTWS------------VGLSLSLPLFDGGRNRARVRAAKAQLEQAEAQYEQT 277
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976 342 HRSVVQTVRSSFNNINASISSINAYKQAVVSAQSSLDAMEAGYSVGTRTIVDVLDATTTLYNAKQELANARYNYLINQLN 421
Cdd:COG1538  278 VLQALQEVEDALAALRAAREQLEALEEALEAAEEALELARARYRAGLASLLDVLDAQRELLQAQLNLIQARYDYLLALVQ 357
                        410
                 ....*....|
gi 446657976 422 IKSALGTLNE 431
Cdd:COG1538  358 LYRALGGGWE 367
OEP pfam02321
Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric ...
236-427 3.37e-22

Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.


Pssm-ID: 396757 [Multi-domain]  Cd Length: 181  Bit Score: 93.74  E-value: 3.37e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976  236 KEAEKRNLSLLQARLSQDLAREQIRQAQDGHLPTLDLTASTGisdtsysgsktRGAAGTQYDDSNMGQNKVGLSFSLPIY 315
Cdd:pfam02321   1 ALALENNPDLKAAEAEIEAAEANIKLAKSEFLPDLSLSGGYG-----------YNSNNSESGGDDPGTGEVGLGLSQPLF 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976  316 QGGMVNSQVKQAQYNFVGASEQLESAHRSVVQTVRSSFNNINASISSINAYKQAVVSAQSSLDAMEAGYSVGTRTIVDVL 395
Cdd:pfam02321  70 DGGKRRARVKAAKAQVEAAEAQLEQARQQLRLEVAQAYLQLLAAKEQLELAEQALELAEEALELAEARYEAGLISLLDVL 149
                         170       180       190
                  ....*....|....*....|....*....|..
gi 446657976  396 DATTTLYNAKQELANARYNYLINQLNIKSALG 427
Cdd:pfam02321 150 QAEVELLEARLELLNAEADLELALAQLEQLLG 181
 
Name Accession Description Interval E-value
tolC PRK09465
outer membrane channel protein; Reviewed
1-451 0e+00

outer membrane channel protein; Reviewed


Pssm-ID: 236529 [Multi-domain]  Cd Length: 446  Bit Score: 798.38  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976   1 MKKLLPILIGLSLYGFSSLSQAENLMQVYQQARLSNPELRKSAADRDAAFEKINEARSPLLPQLGLGADYTYSNGYRDAN 80
Cdd:PRK09465   1 MKKLLPLLIGLSLAGFSSASQAEDLLQVYQQARLSNPELLKAAADRDAAFEKINEARSPLLPQLGLGAGYTYSNGYRDAN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976  81 GINSNATSASLQLTQSIFDMSKWRALTLQEKAAGIQDVTYQTDQQTLILNTATAYFNVLNAIDVLSYTQAQKEAIYRQLD 160
Cdd:PRK09465  81 GIDSNGTSASLQLTQTIFDMSKWRALTLAEKAAGIADVTYQTAQQTLILRTATAYFNVLRAIDNLSFTEAEKRAIYRQLD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976 161 QTTQRFNVGLVAITDVQNARAQYDTVLANEVTARNNLDNAVEQLRQITGNYYPELAALNVENFKTDKPQPVNALLKEAEK 240
Cdd:PRK09465 161 QTTQRFNVGLVAITDVQNAQAQYDTVLANEVLARNNLDNAYEALRQITGNYYPELAVLNTERFSTPKPQSVNALLKEAEK 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976 241 RNLSLLQARLSQDLAREQIRQAQDGHLPTLDLTASTGISDTSYSgsktrGAAGTQYDDSNMGQNKVGLSFSLPIYQGGMV 320
Cdd:PRK09465 241 RNLSLLSARLSQDLAREQIRLAQAGHMPTLDLTASYGISDTSYS-----GANGTQYDDSDMGQNKVGLNLSLPLYSGGAV 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976 321 NSQVKQAQYNFVGASEQLESAHRSVVQTVRSSFNNINASISSINAYKQAVVSAQSSLDAMEAGYSVGTRTIVDVLDATTT 400
Cdd:PRK09465 316 NSQVKQAQYNFVGASEQLESAHRSVVQTVRSSFNNINASISSINAYEQAVVSAQSSLDATEAGYEVGTRTIVDVLDATTT 395
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446657976 401 LYNAKQELANARYNYLINQLNIKSALGTLNEQDLLALNNALSKPVSTNPEN 451
Cdd:PRK09465 396 LYDAKQQLSNARYNYLINQLNLKQALGTLNEQDLLALNNGLGKPVSTSPEN 446
type_I_sec_TolC TIGR01844
type I secretion outer membrane protein, TolC family; Members of this model are outer membrane ...
21-443 2.98e-146

type I secretion outer membrane protein, TolC family; Members of this model are outer membrane proteins from the TolC subfamily within the RND (Resistance-Nodulation-cell Division) efflux systems. These proteins, unlike the NodT subfamily, appear not to be lipoproteins. All are believed to participate in type I protein secretion, an ABC transporter system for protein secretion without cleavage of a signal sequence, although they may, like TolC, participate also in the efflux of smaller molecules as well. This family includes the well-documented examples TolC (E. coli), PrtF (Erwinia), and AprF (Pseudomonas aeruginosa). [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Porins]


Pssm-ID: 273829 [Multi-domain]  Cd Length: 415  Bit Score: 424.86  E-value: 2.98e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976   21 QAENLMQVYQQARLSNPELRKSAADRDAAFEKINEARSPLLPQLGLGADYTYSNGYRD-ANGINS--NATSASLQLTQSI 97
Cdd:TIGR01844   1 AALTLLDAVLLALANNPELRAARAQRDAGEEQVAQARAALLPQLGLTANYGYSNTYPTeSRGRNTdlNSGSSTLTLSQPL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976   98 FD-MSKWRALTLQEKAAGIQDVTYQTDQQTLILNTATAYFNVLNAIDVLSYTQAQKEAIYRQLDQTTQRFNVGLVAITDV 176
Cdd:TIGR01844  81 FDgGSTWNAVRAAEAAALAARETLRATAQDLILRTAEAYMEVLRAQEILALAEANLAALKEQLDLARARFDVGLGTRTDV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976  177 QNARAQYDTVLANEVTARNNLDNAVEQLRQITGNyyPELAALNVENFKTDKPQPVNALLKEAEKRNLSLLQARLSQDLAR 256
Cdd:TIGR01844 161 LQAEARYASARAQLIQAQNNLDDAKAQLRRLVGQ--PELAPLAVPSFPAELPEPLDQLLEIAEASNPLLLAAQAAVDAAR 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976  257 EQIRQAQDGHLPTLDLTASTGISDTSYSGSKTrgaagtqyddSNMGQNKVGLSFSLPIYQGGMVNSQVKQAQYNFVGASE 336
Cdd:TIGR01844 239 YQVEQARAGHLPTLSLTASTGNSDTSSGGSGN----------SDSDTYSVGLNVSIPLYQGGATSAQVRQAAHQLNQSRS 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976  337 QLESAHRSVVQTVRSSFNNINASISSINAYKQAVVSAQSSLDAMEAGYSVGTRTIVDVLDATTTLYNAKQELANARYNYL 416
Cdd:TIGR01844 309 TLESQKRTVRQQVRNAWSNLNAAAASVQAYEQQVASAQKALDAYRQEYQVGTRTLLDVLNAEQELYQARQELANARYDYL 388
                         410       420
                  ....*....|....*....|....*..
gi 446657976  417 INQLNIKSALGTLNEQDLLALNNALSK 443
Cdd:TIGR01844 389 QAQLNLLSATGTLNEADLLLQNAALSK 415
TolC COG1538
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];
24-431 2.70e-63

Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441147 [Multi-domain]  Cd Length: 367  Bit Score: 209.89  E-value: 2.70e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976  24 NLMQVYQQARLSNPELRKSAADRDAAFEKINEARSPLLPQlglgadytysngyrdanginsnatsaslqltQSIFDMSKW 103
Cdd:COG1538    1 TLDELIERALANNPDLRAARARVEAARAQLRQARAGLLPS-------------------------------QELDLGGKR 49
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976 104 RALTLQEKA-AGIQDVTYQTDQQTLILNTATAYFNVLNAIDVLSYTQAQKEAIYRQLDQTTQRFNVGLVAITDVQNARAQ 182
Cdd:COG1538   50 RARIEAAKAqAEAAEADLRAARLDLAAEVAQAYFDLLAAQEQLALAEENLALAEELLELARARYEAGLASRLDVLQAEAQ 129
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976 183 YDTVLANEVTARNNLDNAVEQLRQITGNYYPELAALNVENFKTDK-PQPVNALLKEAEKRNLSLLQARLSQDLAREQIRQ 261
Cdd:COG1538  130 LAQARAQLAQAEAQLAQARNALALLLGLPPPAPLDLPDPLPPLPPlPPSLPGLPSEALERRPDLRAAEAQLEAAEAEIGV 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976 262 AQDGHLPTLDLTASTGISDTSYSGSKTRGAAGtqyddsnmgqnkVGLSFSLPIYQGGMVNSQVKQAQYNFVGASEQLESA 341
Cdd:COG1538  210 ARAAFLPSLSLSASYGYSSSDDLFSGGSDTWS------------VGLSLSLPLFDGGRNRARVRAAKAQLEQAEAQYEQT 277
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976 342 HRSVVQTVRSSFNNINASISSINAYKQAVVSAQSSLDAMEAGYSVGTRTIVDVLDATTTLYNAKQELANARYNYLINQLN 421
Cdd:COG1538  278 VLQALQEVEDALAALRAAREQLEALEEALEAAEEALELARARYRAGLASLLDVLDAQRELLQAQLNLIQARYDYLLALVQ 357
                        410
                 ....*....|
gi 446657976 422 IKSALGTLNE 431
Cdd:COG1538  358 LYRALGGGWE 367
OEP pfam02321
Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric ...
236-427 3.37e-22

Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.


Pssm-ID: 396757 [Multi-domain]  Cd Length: 181  Bit Score: 93.74  E-value: 3.37e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976  236 KEAEKRNLSLLQARLSQDLAREQIRQAQDGHLPTLDLTASTGisdtsysgsktRGAAGTQYDDSNMGQNKVGLSFSLPIY 315
Cdd:pfam02321   1 ALALENNPDLKAAEAEIEAAEANIKLAKSEFLPDLSLSGGYG-----------YNSNNSESGGDDPGTGEVGLGLSQPLF 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976  316 QGGMVNSQVKQAQYNFVGASEQLESAHRSVVQTVRSSFNNINASISSINAYKQAVVSAQSSLDAMEAGYSVGTRTIVDVL 395
Cdd:pfam02321  70 DGGKRRARVKAAKAQVEAAEAQLEQARQQLRLEVAQAYLQLLAAKEQLELAEQALELAEEALELAEARYEAGLISLLDVL 149
                         170       180       190
                  ....*....|....*....|....*....|..
gi 446657976  396 DATTTLYNAKQELANARYNYLINQLNIKSALG 427
Cdd:pfam02321 150 QAEVELLEARLELLNAEADLELALAQLEQLLG 181
outer_NodT TIGR01845
efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this ...
25-427 1.39e-20

efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this model comprise a subfamily of the Outer Membrane Factor (TCDB 1.B.17) porins. OMF proteins operate in conjunction with a primary transporter of the RND, MFS, ABC, or PET systems, and a MFP (membrane fusion protein) to tranport substrates across membranes. The complex thus formed allows transport (export) of various solutes (heavy metal cations; drugs, oligosaccharides, proteins, etc.) across the two envelopes of the Gram-negative bacterial cell envelope in a single energy-coupled step. Current data suggest that the OMF (and not the MFP) is largely responsible for the formation of both the trans-outer membrane and trans-periplasmic channels. The roles played by the MFP have yet to be determined. [Cellular processes, Detoxification, Transport and binding proteins, Porins]


Pssm-ID: 273830 [Multi-domain]  Cd Length: 460  Bit Score: 94.02  E-value: 1.39e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976   25 LMQVYQQARLSNPELRKSAADRDAAFEKINEARSPLLPQLGLGADYTYSNGYRDANGI---NSNATSASLQLTQSiFDMS 101
Cdd:TIGR01845  59 LNALIEEALADNPDLQVAEARLRAARANLRAARADFFPSLGLSASATRQKSSEDASGTtsgGSLSNTSTLTLDVS-YELD 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976  102 KWRALTLQEKAAGIQDVTYQTDQQ----TLILNTATAYFNvlnaidvLSYTQAQKEAIY-------RQLDQTTQRFNVGL 170
Cdd:TIGR01845 138 LFGKVRRAVESALAQLEAAEADSQaarlTLSASIANAYVQ-------LAALRAQLDVYHaalasrrKTLELTQKRYAAGV 210
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976  171 VAITDVQNARAQYDTVLANEVTARNNLDNAVEQLRQITGNYyPELAALNVENFKTDKPQP--VNALLKEAEKRNLSLLQA 248
Cdd:TIGR01845 211 AAASDVRQAEAAVASAEAELPSLDVQIAQARNALAALLGKG-PSRGLAIARPLLLDQLPPdlPLSLPSDLLRRRPDIRAA 289
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976  249 RLSQDLAREQIRQAQDGHLPTLDLTASTGISDTSYSGSKtrgaagtqydDSNMGQNKVGLSFSLPIYQGGMVNSQVKQAQ 328
Cdd:TIGR01845 290 ERRLAAANAQIGVAKAAFFPSITLSASIGLSASQLSRLF----------DGGSRFWSIGPALALPIFDGGSLRAALDSAK 359
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976  329 YNFVGASEQLESAHRSVVQTVRSSFNNINASISSINAYKQAVVSAQSSLDAMEAGYSVGTRTIVDVLDATTTLYNAKQEL 408
Cdd:TIGR01845 360 ATYDAAVAQYRQTVLTAFQEVADALVALQALARRLDAQRQAVEQAQEALSLAQTRYRAGLDSYLTVLEAQRSLLTAQRSL 439
                         410
                  ....*....|....*....
gi 446657976  409 ANARYNYLINQLNIKSALG 427
Cdd:TIGR01845 440 ATLQARRLSDSVALYKALG 458
OEP pfam02321
Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric ...
30-209 1.70e-20

Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.


Pssm-ID: 396757 [Multi-domain]  Cd Length: 181  Bit Score: 88.73  E-value: 1.70e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976   30 QQARLSNPELRKSAADRDAAFEKINEARSPLLPQLGLGADYTYSNGYRDANGINSNATSASLQLTQSIFDMSKWRALTLQ 109
Cdd:pfam02321   1 ALALENNPDLKAAEAEIEAAEANIKLAKSEFLPDLSLSGGYGYNSNNSESGGDDPGTGEVGLGLSQPLFDGGKRRARVKA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976  110 EKAA-GIQDVTYQTDQQTLILNTATAYFNVLNAIDVLSYTQAQKEAIYRQLDQTTQRFNVGLVAITDVQNARAQYDTVLA 188
Cdd:pfam02321  81 AKAQvEAAEAQLEQARQQLRLEVAQAYLQLLAAKEQLELAEQALELAEEALELAEARYEAGLISLLDVLQAEVELLEARL 160
                         170       180
                  ....*....|....*....|.
gi 446657976  189 NEVTARNNLDNAVEQLRQITG 209
Cdd:pfam02321 161 ELLNAEADLELALAQLEQLLG 181
TolC COG1538
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];
232-460 1.32e-11

Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441147 [Multi-domain]  Cd Length: 367  Bit Score: 65.83  E-value: 1.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976 232 NALLKEAEKRNLSLLQARLSQDLAREQIRQAQDGHLPTLdltastgisdtsysgsktrgaagtqyddsnmgqnkvglsfs 311
Cdd:COG1538    3 DELIERALANNPDLRAARARVEAARAQLRQARAGLLPSQ----------------------------------------- 41
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976 312 lPIYQGGMVNSQVKQAQYNFVGASEQLESAHRSVVQTVRSSFNNINASISSINAYKQAVVSAQSSLDAMEAGYSVGTRTI 391
Cdd:COG1538   42 -ELDLGGKRRARIEAAKAQAEAAEADLRAARLDLAAEVAQAYFDLLAAQEQLALAEENLALAEELLELARARYEAGLASR 120
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446657976 392 VDVLDATTTLYNAKQELANARYNYLINQLNIKSALGTLNEQDLLALNNALSKPVSTNPENVAPQTPEQN 460
Cdd:COG1538  121 LDVLQAEAQLAQARAQLAQAEAQLAQARNALALLLGLPPPAPLDLPDPLPPLPPLPPSLPGLPSEALER 189
PRK09837 PRK09837
Cu(I)/Ag(I) efflux RND transporter outer membrane protein;
127-427 6.30e-04

Cu(I)/Ag(I) efflux RND transporter outer membrane protein;


Pssm-ID: 182103 [Multi-domain]  Cd Length: 461  Bit Score: 42.17  E-value: 6.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976 127 LILNTATAYFNVLNAIDVLSYTQAQKEAIYRQLDQTTQRFNVGLVAITDVQNARAQYDTVLANEVTARNNLDNAVEQLRQ 206
Cdd:PRK09837 166 LVSNVAQSYFNQQLAYAQLQIAEETLRNYQQSYAFVEKQLLTGSSNVLALEQARGVIESTRADIAKRQGELAQANNALQL 245
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976 207 ITGNY--YPELAALN---VENFKTDKPQPVNALLKEAEkrnlsLLQARLSQDLAREQIRQAQDGHLPTLDLTASTGISDT 281
Cdd:PRK09837 246 LLGSYgkLPQAQTVNsdsLQSVKLPAGLSSQILLQRPD-----IMEAEHALMAANANIGAARAAFFPSISLTSGLSTSSS 320
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446657976 282 SYSGSKTRGAAGTQYDDSnmgqnkvglsFSLPIYQGGMVNSQVKQA----QYNFVGASEQLESAHRSVVQTV--RSSFNN 355
Cdd:PRK09837 321 DLSSLFNASSGMWNFIPK----------IEIPIFNAGRNQANLDLAeirqQQSVVNYEQKIQNAFKEVADALalRQSLND 390
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446657976 356 inasisSINAYKQAVVSAQSSLDAMEAGYSVGTRTIVDVLDATTTLYNAKQELANARYNYLINQLNIKSALG 427
Cdd:PRK09837 391 ------QISAQQRYLASLQITLQRARALYQHGAVSYLEVLDAERSLFATRQTLLDLNYARQVNEISLFTALG 456
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH