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Conserved domains on  [gi|446614036|ref|WP_000691382|]
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MULTISPECIES: Trk system potassium transporter TrkA [Enterobacterales]

Protein Classification

Trk system potassium transport protein TrkA( domain architecture ID 11484302)

Trk system potassium transport protein TrkA may regulate the transport activity of the constitutive potassium transport TrkG and TrkH systems; binds to NAD(+) and NADH

Gene Ontology:  GO:0006813

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
trkA PRK09496
Trk system potassium transporter TrkA;
1-456 0e+00

Trk system potassium transporter TrkA;


:

Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 729.61  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036   1 MKIIILGAGQVGGTLAENLVGENNDITVVDTNGERLRTLQDKFDLRVVQGHGSHPRVLREAGADDADMLVAVTSSDETNM 80
Cdd:PRK09496   1 MKIIIVGAGQVGYTLAENLSGENNDVTVIDTDEERLRRLQDRLDVRTVVGNGSSPDVLREAGAEDADLLIAVTDSDETNM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036  81 VACQVAYSLFNTPNRIARIRSPDYvRDADKLFHSDAVPIDHLIAPEQLVIDNIYRLIEYPGALQVVNFAEGKVSLAVVKA 160
Cdd:PRK09496  81 VACQIAKSLFGAPTTIARVRNPEY-AEYDKLFSKEALGIDLLISPELLVAREIARLIEYPGALDVEEFADGRVQLVEVKV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036 161 YYGGPLIGNALSTMREHMPHIDTRVAAIFRHDRPIRPQGSTIVEAGDEVFFIAASQHIRAVMSELQRLEKPYKRIMLVGG 240
Cdd:PRK09496 160 YEGSPLVGKPLSDLREHFPDIDVRVVAIFRGGRLIIPRGDTVIEAGDEVYFIGAREHIRAVMSEFGRLEKPVKRVMIVGG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036 241 GNIGAGLARRLEK-DYSVKLIERNQQRAAELAEKLQNTIVFFGDASDQELLAEEHIDQVDLFIAVTNDDEANIMSAMLAK 319
Cdd:PRK09496 240 GNIGYYLAKLLEKeGYSVKLIERDPERAEELAEELPNTLVLHGDGTDQELLEEEGIDEADAFIALTNDDEANILSSLLAK 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036 320 RMGAKKVMVLIQRRAYVDLVQGSVIDIAISPQQATISALLSHVRKADIVGVSSLRRGVAEAIEAVAHgdeSTSRVVGRVI 399
Cdd:PRK09496 320 RLGAKKVIALVNRPAYVDLVEGLGIDIAISPRQATASEILRHVRRGDIVAVHSLRRGAAEAIEAVAH---ETSKVVGKPL 396

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446614036 400 DEIKLPPGTIIGAVVRGNDVMIANDNLRIEQGDHVIMFLTDKKFITDVERLFQPSPF 456
Cdd:PRK09496 397 KDLKLPKGVLIGAIVRGGEVIIPTGDTVIEPGDHVIVFVLDKKFVPDVEKLFQVSPF 453
 
Name Accession Description Interval E-value
trkA PRK09496
Trk system potassium transporter TrkA;
1-456 0e+00

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 729.61  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036   1 MKIIILGAGQVGGTLAENLVGENNDITVVDTNGERLRTLQDKFDLRVVQGHGSHPRVLREAGADDADMLVAVTSSDETNM 80
Cdd:PRK09496   1 MKIIIVGAGQVGYTLAENLSGENNDVTVIDTDEERLRRLQDRLDVRTVVGNGSSPDVLREAGAEDADLLIAVTDSDETNM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036  81 VACQVAYSLFNTPNRIARIRSPDYvRDADKLFHSDAVPIDHLIAPEQLVIDNIYRLIEYPGALQVVNFAEGKVSLAVVKA 160
Cdd:PRK09496  81 VACQIAKSLFGAPTTIARVRNPEY-AEYDKLFSKEALGIDLLISPELLVAREIARLIEYPGALDVEEFADGRVQLVEVKV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036 161 YYGGPLIGNALSTMREHMPHIDTRVAAIFRHDRPIRPQGSTIVEAGDEVFFIAASQHIRAVMSELQRLEKPYKRIMLVGG 240
Cdd:PRK09496 160 YEGSPLVGKPLSDLREHFPDIDVRVVAIFRGGRLIIPRGDTVIEAGDEVYFIGAREHIRAVMSEFGRLEKPVKRVMIVGG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036 241 GNIGAGLARRLEK-DYSVKLIERNQQRAAELAEKLQNTIVFFGDASDQELLAEEHIDQVDLFIAVTNDDEANIMSAMLAK 319
Cdd:PRK09496 240 GNIGYYLAKLLEKeGYSVKLIERDPERAEELAEELPNTLVLHGDGTDQELLEEEGIDEADAFIALTNDDEANILSSLLAK 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036 320 RMGAKKVMVLIQRRAYVDLVQGSVIDIAISPQQATISALLSHVRKADIVGVSSLRRGVAEAIEAVAHgdeSTSRVVGRVI 399
Cdd:PRK09496 320 RLGAKKVIALVNRPAYVDLVEGLGIDIAISPRQATASEILRHVRRGDIVAVHSLRRGAAEAIEAVAH---ETSKVVGKPL 396

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446614036 400 DEIKLPPGTIIGAVVRGNDVMIANDNLRIEQGDHVIMFLTDKKFITDVERLFQPSPF 456
Cdd:PRK09496 397 KDLKLPKGVLIGAIVRGGEVIIPTGDTVIEPGDHVIVFVLDKKFVPDVEKLFQVSPF 453
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 137-435 8.31e-68

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 218.40  E-value: 8.31e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036 137 IEYPGALQVVNFAEGKVSLAVVKAYYGGPLIGNALSTMREHMPHIDTRVAAIFRHDRPIRPQGSTIVEAGDEVFFIAASQ 216
Cdd:COG0569    1 LLILLLLLVLLFAMGIEGLVLLDALYGLLITLTTVTTLGGGLLDPVTLVAAIFLIGVVIIPLGYTLITFGDAVLFGGLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036 217 HIRAVMSELQRLEKPyKRIMLVGGGNIGAGLARRLEK-DYSVKLIERNQQRAAELAEKlqNTIVFFGDASDQELLAEEHI 295
Cdd:COG0569   81 ALRRRRMERGIKKLK-MHVIIIGAGRVGRSLARELEEeGHDVVVIDKDPERVERLAEE--DVLVIVGDATDEEVLEEAGI 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036 296 DQVDLFIAVTNDDEANIMSAMLAKRMGAKKVMVLIQRRAYVDLVQGSVIDIAISPQQATISALLSHVRKADIVGVSSLRR 375
Cdd:COG0569  158 EDADAVIAATGDDEANILACLLAKELGVPRIIARANDPEYADLLERLGADVVISPERLAARRIARLLLRPGVLDVLELAD 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446614036 376 GVAEAIEAVAHgdeSTSRVVGRVIDEIKLPP--GTIIGAVVRGNDVMIANDNLRIEQGDHVI 435
Cdd:COG0569  238 GDAEIVEVTVP---EGSPLVGKTLKELDLREryGVTVVAIKRGGEVIIPSGDTVLEAGDELI 296
TrkA_N pfam02254
TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include ...
 235-350 1.32e-26

TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.


Pssm-ID: 426679 [Multi-domain]  Cd Length: 115  Bit Score: 103.37  E-value: 1.32e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036  235 IMLVGGGNIGAGLARRLEKDYSVKLIERNQQRAAELAEKLqnTIVFFGDASDQELLAEEHIDQVDLFIAVTNDDEANIMS 314
Cdd:pfam02254   1 IIIIGYGRVGRSLAEELSEGGDVVVIDKDEERVEELREEG--VPVVVGDATDEEVLEEAGIEEADAVIAATGDDEANILI 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 446614036  315 AMLAKRM-GAKKVMVLIQRRAYVDLVQGSVIDIAISP 350
Cdd:pfam02254  79 VLLARELnPDKKIIARANDPEHAELLRRLGADHVISP 115
L-AlaDH cd05305
Alanine dehydrogenase NAD-binding and catalytic domains; Alanine dehydrogenase (L-AlaDH) ...
 2-72 1.84e-05

Alanine dehydrogenase NAD-binding and catalytic domains; Alanine dehydrogenase (L-AlaDH) catalyzes the NAD-dependent conversion of pyruvate to L-alanine via reductive amination. Like formate dehydrogenase and related enzymes, L-AlaDH is comprised of 2 domains connected by a long alpha helical stretch, each resembling a Rossmann fold NAD-binding domain. The NAD-binding domain is inserted within the linear sequence of the more divergent catalytic domain. Ligand binding and active site residues are found in the cleft between the subdomains. L-AlaDH is typically hexameric and is critical in carbon and nitrogen metabolism in micro-organisms.


Pssm-ID: 240630 [Multi-domain]  Cd Length: 359  Bit Score: 46.63  E-value: 1.84e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446614036   2 KIIILGAGQVGGTLAENLVGENNDITVVDTNGERLRTLQDKFDLRVVQGHgSHPRVLREAgADDADMLV-AV 72
Cdd:cd05305  170 KVVILGAGVVGENAARVALGLGAEVTVLDINLERLRYLDDIFGGRVTTLY-SNPANLEEA-LKEADLVIgAV 239
 
Name Accession Description Interval E-value
trkA PRK09496
Trk system potassium transporter TrkA;
1-456 0e+00

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 729.61  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036   1 MKIIILGAGQVGGTLAENLVGENNDITVVDTNGERLRTLQDKFDLRVVQGHGSHPRVLREAGADDADMLVAVTSSDETNM 80
Cdd:PRK09496   1 MKIIIVGAGQVGYTLAENLSGENNDVTVIDTDEERLRRLQDRLDVRTVVGNGSSPDVLREAGAEDADLLIAVTDSDETNM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036  81 VACQVAYSLFNTPNRIARIRSPDYvRDADKLFHSDAVPIDHLIAPEQLVIDNIYRLIEYPGALQVVNFAEGKVSLAVVKA 160
Cdd:PRK09496  81 VACQIAKSLFGAPTTIARVRNPEY-AEYDKLFSKEALGIDLLISPELLVAREIARLIEYPGALDVEEFADGRVQLVEVKV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036 161 YYGGPLIGNALSTMREHMPHIDTRVAAIFRHDRPIRPQGSTIVEAGDEVFFIAASQHIRAVMSELQRLEKPYKRIMLVGG 240
Cdd:PRK09496 160 YEGSPLVGKPLSDLREHFPDIDVRVVAIFRGGRLIIPRGDTVIEAGDEVYFIGAREHIRAVMSEFGRLEKPVKRVMIVGG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036 241 GNIGAGLARRLEK-DYSVKLIERNQQRAAELAEKLQNTIVFFGDASDQELLAEEHIDQVDLFIAVTNDDEANIMSAMLAK 319
Cdd:PRK09496 240 GNIGYYLAKLLEKeGYSVKLIERDPERAEELAEELPNTLVLHGDGTDQELLEEEGIDEADAFIALTNDDEANILSSLLAK 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036 320 RMGAKKVMVLIQRRAYVDLVQGSVIDIAISPQQATISALLSHVRKADIVGVSSLRRGVAEAIEAVAHgdeSTSRVVGRVI 399
Cdd:PRK09496 320 RLGAKKVIALVNRPAYVDLVEGLGIDIAISPRQATASEILRHVRRGDIVAVHSLRRGAAEAIEAVAH---ETSKVVGKPL 396

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446614036 400 DEIKLPPGTIIGAVVRGNDVMIANDNLRIEQGDHVIMFLTDKKFITDVERLFQPSPF 456
Cdd:PRK09496 397 KDLKLPKGVLIGAIVRGGEVIIPTGDTVIEPGDHVIVFVLDKKFVPDVEKLFQVSPF 453
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 137-435 8.31e-68

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 218.40  E-value: 8.31e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036 137 IEYPGALQVVNFAEGKVSLAVVKAYYGGPLIGNALSTMREHMPHIDTRVAAIFRHDRPIRPQGSTIVEAGDEVFFIAASQ 216
Cdd:COG0569    1 LLILLLLLVLLFAMGIEGLVLLDALYGLLITLTTVTTLGGGLLDPVTLVAAIFLIGVVIIPLGYTLITFGDAVLFGGLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036 217 HIRAVMSELQRLEKPyKRIMLVGGGNIGAGLARRLEK-DYSVKLIERNQQRAAELAEKlqNTIVFFGDASDQELLAEEHI 295
Cdd:COG0569   81 ALRRRRMERGIKKLK-MHVIIIGAGRVGRSLARELEEeGHDVVVIDKDPERVERLAEE--DVLVIVGDATDEEVLEEAGI 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036 296 DQVDLFIAVTNDDEANIMSAMLAKRMGAKKVMVLIQRRAYVDLVQGSVIDIAISPQQATISALLSHVRKADIVGVSSLRR 375
Cdd:COG0569  158 EDADAVIAATGDDEANILACLLAKELGVPRIIARANDPEYADLLERLGADVVISPERLAARRIARLLLRPGVLDVLELAD 237

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446614036 376 GVAEAIEAVAHgdeSTSRVVGRVIDEIKLPP--GTIIGAVVRGNDVMIANDNLRIEQGDHVI 435
Cdd:COG0569  238 GDAEIVEVTVP---EGSPLVGKTLKELDLREryGVTVVAIKRGGEVIIPSGDTVLEAGDELI 296
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 1-210 1.67e-54

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 183.73  E-value: 1.67e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036   1 MKIIILGAGQVGGTLAENLVGENNDITVVDTNGERLRTLQDKfDLRVVQGHGSHPRVLREAGADDADMLVAVTSSDETNM 80
Cdd:COG0569   96 MHVIIIGAGRVGRSLARELEEEGHDVVVIDKDPERVERLAEE-DVLVIVGDATDEEVLEEAGIEDADAVIAATGDDEANI 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036  81 VACQVAYSLfNTPNRIARIRSPDYVRDADKLfhsdavPIDHLIAPEQLVIDNIYRLIEYPGALQVVNFAEGKVSLAVVKA 160
Cdd:COG0569  175 LACLLAKEL-GVPRIIARANDPEYADLLERL------GADVVISPERLAARRIARLLLRPGVLDVLELADGDAEIVEVTV 247

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 446614036 161 YYGGPLIGNALSTMREHMPHiDTRVAAIFRHDRPIRPQGSTIVEAGDEVF 210
Cdd:COG0569  248 PEGSPLVGKTLKELDLRERY-GVTVVAIKRGGEVIIPSGDTVLEAGDELI 296
TrkA_N pfam02254
TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include ...
 235-350 1.32e-26

TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.


Pssm-ID: 426679 [Multi-domain]  Cd Length: 115  Bit Score: 103.37  E-value: 1.32e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036  235 IMLVGGGNIGAGLARRLEKDYSVKLIERNQQRAAELAEKLqnTIVFFGDASDQELLAEEHIDQVDLFIAVTNDDEANIMS 314
Cdd:pfam02254   1 IIIIGYGRVGRSLAEELSEGGDVVVIDKDEERVEELREEG--VPVVVGDATDEEVLEEAGIEEADAVIAATGDDEANILI 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 446614036  315 AMLAKRM-GAKKVMVLIQRRAYVDLVQGSVIDIAISP 350
Cdd:pfam02254  79 VLLARELnPDKKIIARANDPEHAELLRRLGADHVISP 115
TrkA_N pfam02254
TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include ...
 3-106 1.60e-26

TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.


Pssm-ID: 426679 [Multi-domain]  Cd Length: 115  Bit Score: 102.99  E-value: 1.60e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036    3 IIILGAGQVGGTLAENLVgENNDITVVDTNGERLRTLQDKFdLRVVQGHGSHPRVLREAGADDADMLVAVTSSDETNMVA 82
Cdd:pfam02254   1 IIIIGYGRVGRSLAEELS-EGGDVVVIDKDEERVEELREEG-VPVVVGDATDEEVLEEAGIEEADAVIAATGDDEANILI 78

                          90       100
                  ....*....|....*....|....
gi 446614036   83 CQVAYSLFNTPNRIARIRSPDYVR 106
Cdd:pfam02254  79 VLLARELNPDKKIIARANDPEHAE 102
Kch COG1226
Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];
3-116 6.04e-12

Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];


Pssm-ID: 440839 [Multi-domain]  Cd Length: 279  Bit Score: 65.91  E-value: 6.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036   3 IIILGAGQVGGTLAENLVGENNDITVVDTNGERLRTLQdKFDLRVVQGHGSHPRVLREAGADDADMLVAVTSSDETNMVA 82
Cdd:COG1226  127 VIIAGFGRVGQIVARLLRAEGIPFVVIDLDPERVEELR-RFGIKVYYGDATRPDVLEAAGIERARALVVAIDDPEAALRI 205

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446614036  83 CQVAYSLFNTPNRIARIRSPDyvrDADKLFHSDA 116
Cdd:COG1226  206 VELARELNPDLKIIARARDRE---HAEELRQAGA 236
NhaP2 COG3263
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy ...
 392-455 3.90e-09

NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 442494 [Multi-domain]  Cd Length: 502  Bit Score: 58.58  E-value: 3.90e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446614036 392 SRVVGRVIDEIKLPPGTIIGAVVRGNDVMIANDNLRIEQGDHVIMFLTDKKfITDVERLFQPSP 455
Cdd:COG3263  424 SPAVGKTLRELRLPEGALVVLIVRDGELLVPRGSTRLQAGDQLLVLAPPED-LEALERLFAAVS 486
PRK05326 PRK05326
potassium/proton antiporter;
392-455 4.18e-08

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 55.59  E-value: 4.18e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446614036 392 SRVVGRVIDEIKLPPGTIIGAVVRGNDVMIANDNLRIEQGDHVIMFLTDKKfITDVERLFQPSP 455
Cdd:PRK05326 425 SWLVGKALRDLRLPRGALIALIIRDGKLLVPTGSTRLKAGDVLLVLGPERD-LPALERLFSQSP 487
PRK05326 PRK05326
potassium/proton antiporter;
165-300 1.11e-06

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 50.97  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036 165 PLIGNALstMREHMPHiDTRVAAIFRHDRPIRPQGSTIVEAGDEVFFIAASQHIRAVMSELQrlEKPYKRIMLVGGGNIG 244
Cdd:PRK05326 426 WLVGKAL--RDLRLPR-GALIALIIRDGKLLVPTGSTRLKAGDVLLVLGPERDLPALERLFS--QSPPGKLDQRFFGDFI 500

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036 245 AGLARRLEKDYSVKLIERNQQRAAELAEKLQNTIVFFGD----ASDQELLAEEHIDQVDL 300
Cdd:PRK05326 501 LEGDAKLADLALIYGLELDQQTLGELIKQRLGGAPVVGDqvelGGIILTVAEGRVTKVGL 560
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 155-225 1.13e-06

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 46.06  E-value: 1.13e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446614036  155 LAVVKAYYGGPLIGNALS--TMREHMphiDTRVAAIFRHDRPIRPQGSTIVEAGDEVFFIAASQHIRAVMSEL 225
Cdd:pfam02080   1 LVEVTVPENSPLVGKTLKelNLPERF---GVRIVAIRRGGRLIIPSGDTVLEAGDRLLVIGTPDDLAALRELL 70
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 390-451 1.65e-05

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 42.60  E-value: 1.65e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446614036  390 STSRVVGRVIDEIKLP--PGTIIGAVVRGNDVMIANDNLRIEQGDHVImFLTDKKFITDVERLF 451
Cdd:pfam02080   8 ENSPLVGKTLKELNLPerFGVRIVAIRRGGRLIIPSGDTVLEAGDRLL-VIGTPDDLAALRELL 70
L-AlaDH cd05305
Alanine dehydrogenase NAD-binding and catalytic domains; Alanine dehydrogenase (L-AlaDH) ...
 2-72 1.84e-05

Alanine dehydrogenase NAD-binding and catalytic domains; Alanine dehydrogenase (L-AlaDH) catalyzes the NAD-dependent conversion of pyruvate to L-alanine via reductive amination. Like formate dehydrogenase and related enzymes, L-AlaDH is comprised of 2 domains connected by a long alpha helical stretch, each resembling a Rossmann fold NAD-binding domain. The NAD-binding domain is inserted within the linear sequence of the more divergent catalytic domain. Ligand binding and active site residues are found in the cleft between the subdomains. L-AlaDH is typically hexameric and is critical in carbon and nitrogen metabolism in micro-organisms.


Pssm-ID: 240630 [Multi-domain]  Cd Length: 359  Bit Score: 46.63  E-value: 1.84e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446614036   2 KIIILGAGQVGGTLAENLVGENNDITVVDTNGERLRTLQDKFDLRVVQGHgSHPRVLREAgADDADMLV-AV 72
Cdd:cd05305  170 KVVILGAGVVGENAARVALGLGAEVTVLDINLERLRYLDDIFGGRVTTLY-SNPANLEEA-LKEADLVIgAV 239
Ald COG0686
Alanine dehydrogenase (includes sporulation protein SpoVN) [Amino acid transport and ...
 2-72 1.89e-05

Alanine dehydrogenase (includes sporulation protein SpoVN) [Amino acid transport and metabolism]; Alanine dehydrogenase (includes sporulation protein SpoVN) is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440450 [Multi-domain]  Cd Length: 372  Bit Score: 46.54  E-value: 1.89e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446614036   2 KIIILGAGQVGGTLAENLVGENNDITVVDTNGERLRTLQDKFDLRVVQGHgSHPRVLREAgADDADMLV-AV 72
Cdd:COG0686  170 KVVILGGGVVGTNAARMALGLGADVTVLDINLDRLRRLDDIFGGRVTTLY-SNPANIEEA-LKEADLVIgAV 239
Kch COG1226
Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];
234-321 2.71e-05

Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];


Pssm-ID: 440839 [Multi-domain]  Cd Length: 279  Bit Score: 45.88  E-value: 2.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036 234 RIMLVGGGNIGAGLARRLE-KDYSVKLIERNQQRAAELAEklQNTIVFFGDASDQELLAEEHIDQVDLFIAVTNDDEANI 312
Cdd:COG1226  126 HVIIAGFGRVGQIVARLLRaEGIPFVVIDLDPERVEELRR--FGIKVYYGDATRPDVLEAAGIERARALVVAIDDPEAAL 203


                 ....*....
gi 446614036 313 MSAMLAKRM 321
Cdd:COG1226  204 RIVELAREL 212
PRK08219 PRK08219
SDR family oxidoreductase;
239-302 3.19e-04

SDR family oxidoreductase;


Pssm-ID: 181298 [Multi-domain]  Cd Length: 227  Bit Score: 42.23  E-value: 3.19e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446614036 239 GGGNIGAGLARRLEKDYSVKLIERNQQRAAELAEKLQNTIVFFGDASDQELLAE--EHIDQVDLFI 302
Cdd:PRK08219  11 ASRGIGAAIARELAPTHTLLLGGRPAERLDELAAELPGATPFPVDLTDPEAIAAavEQLGRLDVLV 76
PRK06522 PRK06522
2-dehydropantoate 2-reductase; Reviewed
 1-51 6.05e-04

2-dehydropantoate 2-reductase; Reviewed


Pssm-ID: 235821 [Multi-domain]  Cd Length: 304  Bit Score: 41.76  E-value: 6.05e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446614036   1 MKIIILGAGQVGGTLAENLVGENNDITVVDTNGERLRTLQDKfDLRVVQGH 51
Cdd:PRK06522   1 MKIAILGAGAIGGLFGAALAQAGHDVTLVARRGAHLDALNEN-GLRLEDGE 50
NAD_bind_Leu_Phe_Val_DH cd01075
NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine ...
 1-48 1.09e-03

NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Amino acid dehydrogenase (DH) is a widely distributed family of enzymes that catalyzes the oxidative deamination of an amino acid to its keto acid and ammonia with concomitant reduction of NADP+. For example, leucine DH catalyzes the reversible oxidative deamination of L-leucine and several other straight or branched chain amino acids to the corresponding 2-oxoacid derivative. Amino acid DH -like NAD(P)-binding domains are members of the Rossmann fold superfamily and include glutamate, leucine, and phenylalanine DHs, methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.


Pssm-ID: 133444  Cd Length: 200  Bit Score: 40.27  E-value: 1.09e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 446614036   1 MKIIILGAGQVGGTLAENLVGENNDITVVDTNGERLRTLQDKFDLRVV 48
Cdd:cd01075   29 KTVAVQGLGKVGYKLAEHLLEEGAKLIVADINEEAVARAAELFGATVV 76
WcaG COG0451
Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis];
2-70 1.10e-03

Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440220 [Multi-domain]  Cd Length: 295  Bit Score: 40.73  E-value: 1.10e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036   2 KIIILGA-GQVGGTLAENLVGENNDITVVDTNGERLRTLQDKFDLRVVQGHGSHPRVLREAgADDADMLV 70
Cdd:COG0451    1 RILVTGGaGFIGSHLARRLLARGHEVVGLDRSPPGAANLAALPGVEFVRGDLRDPEALAAA-LAGVDAVV 69
NAD_binding_7 pfam13241
Putative NAD(P)-binding; This domain is found in fungi, plants, archaea and bacteria.
 233-311 2.01e-03

Putative NAD(P)-binding; This domain is found in fungi, plants, archaea and bacteria.


Pssm-ID: 433055 [Multi-domain]  Cd Length: 104  Bit Score: 37.46  E-value: 2.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036  233 KRIMLVGGGNIGAGLARRL-EKDYSVKLIernqqrAAELAEKLQNTIvffgDASDQELlaEEHIDQVDLFIAVTNDDEAN 311
Cdd:pfam13241   8 KRVLVVGGGEVAARKARKLlEAGAKVTVV------SPEITPFLEGLL----DLIRREF--EGDLDGADLVIAATDDPELN 75
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 1-72 2.35e-03

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 39.66  E-value: 2.35e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446614036   1 MKIIILGAGQVGGTLAENLVG---ENNDITVVDTNGERLRTLQDKFDLRVVQGhgshprvLREAgADDADMLV-AV 72
Cdd:COG0345    3 MKIGFIGAGNMGSAIIKGLLKsgvPPEDIIVSDRSPERLEALAERYGVRVTTD-------NAEA-AAQADVVVlAV 70
MviM COG0673
Predicted dehydrogenase [General function prediction only];
234-307 2.69e-03

Predicted dehydrogenase [General function prediction only];


Pssm-ID: 440437 [Multi-domain]  Cd Length: 295  Bit Score: 39.52  E-value: 2.69e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446614036 234 RIMLVGGGNIGAGLARRLEKDYSVKLI---ERNQQRAAELAEKLQntIVFFGDAsdQELLAEEHIDQVdlFIAVTND 307
Cdd:COG0673    5 RVGIIGAGGIGRAHAPALAALPGVELVavaDRDPERAEAFAEEYG--VRVYTDY--EELLADPDIDAV--VIATPNH 75
NmrA pfam05368
NmrA-like family; NmrA is a negative transcriptional regulator involved in the ...
 235-324 3.06e-03

NmrA-like family; NmrA is a negative transcriptional regulator involved in the post-translational modification of the transcription factor AreA. NmrA is part of a system controlling nitrogen metabolite repression in fungi. This family only contains a few sequences as iteration results in significant matches to other Rossmann fold families.


Pssm-ID: 398829 [Multi-domain]  Cd Length: 236  Bit Score: 39.25  E-value: 3.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036  235 IMLVGG-GNIGAGLARRLEKD-YSVKLIERNQQRaaELAEKLQ---NTIVFfGDASDQELLAEEhIDQVDLFIAVTN--- 306
Cdd:pfam05368   1 ILVFGAtGQQGGSVVRASLKAgHKVRALVRDPKS--ELAKSLKeagVELVK-GDLDDKESLVEA-LKGVDVVFSVTGfwa 76

                          90       100
                  ....*....|....*....|..
gi 446614036  307 ----DDEANIMSAmlAKRMGAK 324
Cdd:pfam05368  77 gkeiEDGKKLADA--AKEAGVK 96
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
238-274 6.05e-03

Predicted dinucleotide-binding enzyme [General function prediction only];


Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 37.84  E-value: 6.05e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 446614036 238 VGGGNIGAGLARRL-EKDYSVKLIERNQQRAAELAEKL 274
Cdd:COG2085    4 IGTGNIGSALARRLaAAGHEVVIGSRDPEKAAALAAEL 41
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
 330-451 6.98e-03

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 38.95  E-value: 6.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446614036 330 IQRRAYV----DLVQGSVIDI-AISPQQATISALL-----------SHVRKADIVGVSSLRRGVAEAIEAVahGDESTSR 393
Cdd:COG2985  202 LVTRAYRvtnpNLVGKTVAELeALLGTRVVISRIRrggeiivptpdTVLQEGDIVLVVGTREALEAAEALL--GEEVDDS 279

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446614036 394 ------------------VVGRVIDEIKLPP--GTIIGAVVRGNDVMIANDNLRIEQGDhVIMFLTDKKFITDVERLF 451
Cdd:COG2985  280 elldsdldvrrivvtnkeVAGKTLGELNLRNrfGVVITRVRRGGVELPATPDTVLQLGD-RLTVVGPKEDVERVAKLL 356
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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