|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09922 |
PRK09922 |
lipopolysaccharide 1,6-galactosyltransferase; |
1-357 |
0e+00 |
|
lipopolysaccharide 1,6-galactosyltransferase;
Pssm-ID: 182148 [Multi-domain] Cd Length: 359 Bit Score: 659.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 1 MKIAFIGEAVSGFGGMETVIRDVITTFRQQHIYSEMFFFCRNDKMDKGWLEGIKYSCSFSNIRLGFLRRAKHIHALSKWL 80
Cdd:PRK09922 1 MKIAFIGEAVSGFGGMETVISNVINTFEESKINCEMFFFCRNDKMDKAWLKEIKYAQSFSNIKLSFLRRAKHVYNFSKWL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 81 QDYQPDVVICIDVISCLYAAKARKKSGIDVPVFSWPHFSLDHKKHAEY--ITCADYHLAISSGIKQQMINRGVPESTINV 158
Cdd:PRK09922 81 KETQPDIVICIDVISCLYANKARKKSGKQFKIFSWPHFSLDHKKHAECkkITCADYHLAISSGIKEQMMARGISAQRISV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 159 IFNPVEAKDTVIPGPEEGETATFIYVGRMKFEGQKRVKDLLDGLSQAQGDWKLHVLGDGSDFEKCQAYGRELKIDNRIVW 238
Cdd:PRK09922 161 IYNPVEIKTIIIPPPERDKPAVFLYVGRLKFEGQKNVKELFDGLSQTTGEWQLHIIGDGSDFEKCKAYSRELGIEQRIIW 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 239 HGWQKHPWEVVRQDIKKVSALLLTSSFEGFPMTLLESMSWGIPCISADCVSGPGDIIQPDVNGHLYQPGDIAGFVTLLNK 318
Cdd:PRK09922 241 HGWQSQPWEVVQQKIKNVSALLLTSKFEGFPMTLLEAMSYGIPCISSDCMSGPRDIIKPGLNGELYTPGNIDEFVGKLNK 320
|
330 340 350
....*....|....*....|....*....|....*....
gi 446606624 319 YIAGEIHIEHEKIPASIDKFYQSKYYDRLHNIIISAISR 357
Cdd:PRK09922 321 VISGEVKYQHDAIPNSIERFYEVLYFKNLNNALFSKLQK 359
|
|
| GT4_GT28_WabH-like |
cd03811 |
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ... |
2-344 |
8.06e-59 |
|
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.
Pssm-ID: 340839 [Multi-domain] Cd Length: 351 Bit Score: 193.73 E-value: 8.06e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 2 KIAFIGEAVSGfGGMETVIRDVITTFRQQHIYSEMFFFCRNDKMDKGWLEGIKYSCS-FSNIRLGFLRRAKHIHALSKWL 80
Cdd:cd03811 1 KILFVIPSLSG-GGAERVLLNLANALDKRGYDVTLVLLRDEGDLDKQLNGDVKLIRLlIRVLKLIKLGLLKAILKLKRIL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 81 QDYQPDVVICIDVISCLYAAKARKksgIDVPVFSWPHFSLDHKKHAEYITC--------ADYHLAISSGIKQQMI-NRGV 151
Cdd:cd03811 80 KRAKPDVVISFLGFATYIVAKLAA---ARSKVIAWIHSSLSKLYYLKKKLLlklklykkADKIVCVSKGIKEDLIrLGPS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 152 PESTINVIFNPVEAKDTVIP-----GPEEGETATFIYVGRmkFEGQKRVKDLLDGLSQ---AQGDWKLHVLGDGSDFEKC 223
Cdd:cd03811 157 PPEKIEVIYNPIDIDRIRALakepiLNEPEDGPVILAVGR--LDPQKGHDLLIEAFAKlrkKYPDVKLVILGDGPLREEL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 224 QAYGRELKIDNRIVWHGWQKHPWEVvrqdIKKVSALLLTSSFEGFPMTLLESMSWGIPCISADCVsGPGDIIQPDVNGHL 303
Cdd:cd03811 235 EKLAKELGLAERVIFLGFQSNPYPY----LKKADLFVLSSRYEGFPNVLLEAMALGTPVVSTDCP-GPREILDDGENGLL 309
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 446606624 304 YQPGDIAGFVTLLNKYIAGEIHIEHEKIPASIDKFYQSKYY 344
Cdd:cd03811 310 VPDGDAAALAGILAALLQKKLDAALRERLAKAQEAVFREYT 350
|
|
| GT4_AmsD-like |
cd03820 |
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ... |
2-313 |
6.76e-39 |
|
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.
Pssm-ID: 340847 [Multi-domain] Cd Length: 351 Bit Score: 141.61 E-value: 6.76e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 2 KIAFIGEAVSGFGGMETVIRDVITTF----RQQHIYSemffFCRNDKMDKGWL-EGIKYSCSFSNIRLGFLRRAKH---I 73
Cdd:cd03820 1 KIAIVIPSISNAGGAERVAINLANHLakkgYDVTIIS----LDSAEKPPFYELdDNIKIKNLGDRKYSHFKLLLKYfkkV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 74 HALSKWLQDYQPDVVICIDVISCLYAAKArkksGIDVPVFSWPHFSLDH------KKHAEYITCADYHLAISSGIKQQMI 147
Cdd:cd03820 77 RRLRKYLKNNKPDVVISFRTSLLTFLALI----GLKSKLIVWEHNNYEAynkglrRLLLRRLLYKRADKIVVLTEADKLK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 148 NRGVPESTINVIFNPVEAKDTVIPGPEEGEtaTFIYVGRMkfEGQKRVKDLLD---GLSQAQGDWKLHVLGDGSDFEKCQ 224
Cdd:cd03820 153 KYKQPNSNVVVIPNPLSFPSEEPSTNLKSK--RILAVGRL--TYQKGFDLLIEawaLIAKKHPDWKLRIYGDGPEREELE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 225 AYGRELKIDNRIVWHGWQKHPWEVVRQDikkvSALLLTSSFEGFPMTLLESMSWGIPCISADCVSGPGDIIQPDVNGHLY 304
Cdd:cd03820 229 KLIDKLGLEDRVKLLGPTKNIAEEYANS----SIFVLSSRYEGFPMVLLEAMAYGLPIISFDCPTGPSEIIEDGENGLLV 304
|
....*....
gi 446606624 305 QPGDIAGFV 313
Cdd:cd03820 305 PNGDVDALA 313
|
|
| GT4_PimA-like |
cd03801 |
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ... |
2-321 |
3.39e-31 |
|
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.
Pssm-ID: 340831 [Multi-domain] Cd Length: 366 Bit Score: 121.11 E-value: 3.39e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 2 KIAFIG-EAVSGFGGMETVIRDVITTFRQQHIysEMFFFCRNDKMDKGWLEGIKYSCSFSNIRLGFLRRAKHIHALSKWL 80
Cdd:cd03801 1 KILLLSpELPPPVGGAERHVRELARALAARGH--DVTVLTPADPGEPPEELEDGVIVPLLPSLAALLRARRLLRELRPLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 81 QDYQPDVVICIDVISCLYAAKARKKSGIdvPVFSWPHFSLDH-------------KKHAEYITCADYHLAISSGIKQQMI 147
Cdd:cd03801 79 RLRKFDVVHAHGLLAALLAALLALLLGA--PLVVTLHGAEPGrlllllaaerrllARAEALLRRADAVIAVSEALRDELR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 148 NR-GVPESTINVIFNPV----EAKDTVIPGPEEGETATFIYVGRMkfEGQKRVKDLLDGLSQAQ---GDWKLHVLG-DGS 218
Cdd:cd03801 157 ALgGIPPEKIVVIPNGVdlerFSPPLRRKLGIPPDRPVLLFVGRL--SPRKGVDLLLEALAKLLrrgPDVRLVIVGgDGP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 219 DFEKCQAygRELKIDNRIVWHGWQkhPWEVVRQDIKKVSALLLTSSFEGFPMTLLESMSWGIPCISADcVSGPGDIIQPD 298
Cdd:cd03801 235 LRAELEE--LELGLGDRVRFLGFV--PDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVVATD-VGGLPEVVEDG 309
|
330 340
....*....|....*....|...
gi 446606624 299 VNGHLYQPGDIAGFVTLLNKYIA 321
Cdd:cd03801 310 EGGLVVPPDDVEALADALLRLLA 332
|
|
| GT4_CapM-like |
cd03808 |
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ... |
2-310 |
3.07e-28 |
|
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.
Pssm-ID: 340837 [Multi-domain] Cd Length: 358 Bit Score: 112.69 E-value: 3.07e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 2 KIAFIgeaVSGFGGMETVIRDVITTFRQQHIysEMFFFCRNDkmdkGWLEGIKYSCSFSNIRLGFLRRAKH----IHALS 77
Cdd:cd03808 1 KILFI---VNVDGGFQSFRLPLIKALVKKGY--EVHVIAPDG----DKLSDELKELGVKVIDIPILRRGINplkdLKALF 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 78 KW---LQDYQPDVVICIDVISCLYAAKARKKSGIDVPVFS---WPHFSLDHK----------KHAEYITC-------ADY 134
Cdd:cd03808 72 KLyklLKKEKPDIVHCHTPKPGILGRLAARLAGVPKVIYTvhgLGFVFTEGKllrllyllleKLALLFTDkvifvneDDR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 135 HLAISSGIKQQMINRGVPESTINVIFNPVeakdtvIPGPEEGETATFIYVGRM-KfegQKRVKDLLD---GLSQAQGDWK 210
Cdd:cd03808 152 DLAIKKGIIKKKKTVLIPGSGVDLDRFQY------SPESLPSEKVVFLFVARLlK---DKGIDELIEaakILKKKGPNVR 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 211 LHVLGDGSDFEKCQAYGRELKIDNRIVWHGWQKHPWEVvrqdIKKVSALLLTSSFEGFPMTLLESMSWGIPCISADcVSG 290
Cdd:cd03808 223 FLLVGDGELENPSEILIEKLGLEGRIEFLGFRSDVPEL----LAESDVFVLPSYREGLPRSLLEAMAAGRPVITTD-VPG 297
|
330 340
....*....|....*....|
gi 446606624 291 PGDIIQPDVNGHLYQPGDIA 310
Cdd:cd03808 298 CRELVIDGVNGFLVPPGDVE 317
|
|
| Glycos_transf_1 |
pfam00534 |
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ... |
181-325 |
2.02e-23 |
|
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.
Pssm-ID: 425737 [Multi-domain] Cd Length: 158 Bit Score: 94.65 E-value: 2.02e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 181 FIYVGRMKFE-GQKRVKDLLDGLSQAQGDWKLHVLGDGSDFEKCQAYGRELKIDNRIVWHGWQkhPWEVVRQDIKKVSAL 259
Cdd:pfam00534 5 ILFVGRLEPEkGLDLLIKAFALLKEKNPNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFV--SDEDLPELLKIADVF 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446606624 260 LLTSSFEGFPMTLLESMSWGIPCISADcVSGPGDIIQPDVNGHLYQPGDIAGFVTLLNKYIAGEIH 325
Cdd:pfam00534 83 VLPSRYEGFGIVLLEAMACGLPVIASD-VGGPPEVVKDGETGFLVKPNNAEALAEAIDKLLEDEEL 147
|
|
| GT4_WlbH-like |
cd03798 |
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ... |
59-309 |
8.03e-22 |
|
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.
Pssm-ID: 340828 [Multi-domain] Cd Length: 376 Bit Score: 95.14 E-value: 8.03e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 59 FSNIRLGFLRRAKHIHALSKWLQDYQPDVVICIDVISCLYAA-KARKKSGI---------DVPVFSWPH-FSLDHKKHAE 127
Cdd:cd03798 70 KPRLRLLAPLRAPSLAKLLKRRRRGPPDLIHAHFAYPAGFAAaLLARLYGVpyvvtehgsDINVFPPRSlLRKLLRWALR 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 128 YITCAdyhLAISSGIKQQMINRGVPESTINVIFNPVeakDTVI--PGPEEGETAT----FIYVGRmkFEGQKRVKDLLDG 201
Cdd:cd03798 150 RAARV---IAVSKALAEELVALGVPRDRVDVIPNGV---DPARfqPEDRGLGLPLdafvILFVGR--LIPRKGIDLLLEA 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 202 LS---QAQGDWKLHVLGDGSDFEKCQAYGRELKIDNRIVWHGWqkhpweVVRQDIKKV----SALLLTSSFEGFPMTLLE 274
Cdd:cd03798 222 FArlaKARPDVVLLIVGDGPLREALRALAEDLGLGDRVTFTGR------LPHEQVPAYyracDVFVLPSRHEGFGLVLLE 295
|
250 260 270
....*....|....*....|....*....|....*
gi 446606624 275 SMSWGIPCISADCvSGPGDIIQPDVNGHLYQPGDI 309
Cdd:cd03798 296 AMACGLPVVATDV-GGIPEVVGDPETGLLVPPGDA 329
|
|
| Glyco_trans_1_4 |
pfam13692 |
Glycosyl transferases group 1; |
180-313 |
2.06e-21 |
|
Glycosyl transferases group 1;
Pssm-ID: 463957 [Multi-domain] Cd Length: 138 Bit Score: 88.72 E-value: 2.06e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 180 TFIYVGRMKFEgQKRVKDLLD---GLSQAQGDWKLHVLGDGSDfEKCQAygRELKIDNRIVWHGWQKHPWEVVRQdikkV 256
Cdd:pfam13692 3 VILFVGRLHPN-VKGVDYLLEavpLLRKRDNDVRLVIVGDGPE-EELEE--LAAGLEDRVIFTGFVEDLAELLAA----A 74
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 446606624 257 SALLLTSSFEGFPMTLLESMSWGIPCISADcVSGPGDIIQpDVNGHLYQPGDIAGFV 313
Cdd:pfam13692 75 DVFVLPSLYEGFGLKLLEAMAAGLPVVATD-VGGIPELVD-GENGLLVPPGDPEALA 129
|
|
| GT4_WavL-like |
cd03819 |
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ... |
14-312 |
3.84e-20 |
|
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.
Pssm-ID: 340846 [Multi-domain] Cd Length: 345 Bit Score: 90.11 E-value: 3.84e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 14 GGMETVIRDVIttfRQQHI--YSEMFFFCRNDKMDKGWLEGIKYSCSFSNIrlgfLRRAKHIHALSKWLQDYQPDVVICI 91
Cdd:cd03819 11 GGAETYILDLA---RALAErgHRVLVVTAGGPLLPRLRQIGIGLPGLKVPL----LRALLGNVRLARLIRRERIDLIHAH 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 92 DVISCLYAAKARKKSGIDVPVFSwpH----FSLDHKKHAEYI-TCADYHLAISSGIKQQMINR-GVPESTINVIFNPVEA 165
Cdd:cd03819 84 SRAPAWLGWLASRLTGVPLVTTV--HgsylATYHPKDFALAVrARGDRVIAVSELVRDHLIEAlGVDPERIRVIPNGVDT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 166 KDTViPGPEEGETA---------TFIYVGRMKFEgqKRVKDLLD--GLSQAQGDWKLHVLGDGSDFEKCQAYGRELKIDN 234
Cdd:cd03819 162 DRFP-PEAEAEERAqlglpegkpVVGYVGRLSPE--KGWLLLVDaaAELKDEPDFRLLVAGDGPERDEIRRLVERLGLRD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 235 RIVWHGwqkhpwevVRQDIKK----VSALLLTSSFEGFPMTLLESMSWGIPCISADcVSGPGDIIQPDVNGHLYQPGDIA 310
Cdd:cd03819 239 RVTFTG--------FREDVPAalaaSDVVVLPSLHEEFGRVALEAMACGTPVVATD-VGGAREIVVHGRTGLLVPPGDAE 309
|
..
gi 446606624 311 GF 312
Cdd:cd03819 310 AL 311
|
|
| GT4_WbnK-like |
cd03807 |
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ... |
76-313 |
8.45e-19 |
|
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.
Pssm-ID: 340836 [Multi-domain] Cd Length: 362 Bit Score: 86.22 E-value: 8.45e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 76 LSKWLQDYQPDVVICIDVISCLYAAKARKKSGIdVPVFSWPHFSLDHKK----------HAEYITCAdyHLAISSGIKQQ 145
Cdd:cd03807 71 LAKLIRKRNPDVVHTWMYHADLIGGLAAKLAGG-VKVIWSVRSSNIPQRltrlvrklclLLSKFSPA--TVANSSAVAEF 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 146 MINRGVPESTINVIFNPVE----AKDTVIPGPE------EGETATFIYVGRmkFEGQKRVKDLLDGLSQAQ---GDWKLH 212
Cdd:cd03807 148 HQEQGYAKNKIVVIYNGIDlfklSPDDASRARArrrlglAEDRRVIGIVGR--LHPVKDHSDLLRAAALLVethPDLRLL 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 213 VLGDGSDFEKCQAYGRELKIDNRIVWHGWQKHPWEVVRQ-DIkkvsaLLLTSSFEGFPMTLLESMSWGIPCISADcVSGP 291
Cdd:cd03807 226 LVGRGPERPNLERLLLELGLEDRVHLLGERSDVPALLPAmDI-----FVLSSRTEGFPNALLEAMACGLPVVATD-VGGA 299
|
250 260
....*....|....*....|..
gi 446606624 292 GDIIqPDVNGHLYQPGDIAGFV 313
Cdd:cd03807 300 AELV-DDGTGFLVPAGDPQALA 320
|
|
| Glycosyltransferase_GTB-type |
cd01635 |
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ... |
70-303 |
3.62e-16 |
|
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
Pssm-ID: 340816 [Multi-domain] Cd Length: 235 Bit Score: 77.06 E-value: 3.62e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 70 AKHIHALSKWLQDYQPDVVICIDVIScLYAAKARKKSGIDVPVFsWPHFSLDHKKHAEYItcadyhlAISSGIKQQMINR 149
Cdd:cd01635 16 ELHVRALARALAALGHEVTVLALLLL-ALRRILKKLLELKPDVV-HAHSPHAAALAALLA-------ARLLGIPIVVTVH 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 150 GVPESTINVIFNPVEAKDTVIpgpeeGETATFIYVGRMkfEGQKRVKDLLDGLSQA---QGDWKLHVLGDGSDFEKCQAY 226
Cdd:cd01635 87 GPDSLESTRSELLALARLLVS-----LPLADKVSVGRL--VPEKGIDLLLEALALLkarLPDLVLVLVGGGGEREEEEAL 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446606624 227 GRELKIDNRIVWHGWQkhPWEVVRQDIKKVSALLLTSSF-EGFPMTLLESMSWGIPCISADCVSGPGDIIQPDVNGHL 303
Cdd:cd01635 160 AAALGLLERVVIIGGL--VDDEVLELLLAAADVFVLPSRsEGFGLVLLEAMAAGKPVIATDVGGIPEFVVDGENGLLV 235
|
|
| GT4_ExpE7-like |
cd03823 |
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ... |
76-313 |
1.43e-15 |
|
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).
Pssm-ID: 340850 [Multi-domain] Cd Length: 357 Bit Score: 76.98 E-value: 1.43e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 76 LSKWLQDYQPDVVI--CIDVISCLYAAKARKksgIDVPV------FSW--PHFSLDHKKHAEYItcadyhlAISSGIKQQ 145
Cdd:cd03823 88 LARLLEDFRPDVVHthNLSGLGASLLDAARD---LGIPVvhtlhdYWLlcPRQFLFKKGGDAVL-------APSRFTANL 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 146 MINRGVPESTINVIFNPVEA--KDTVIPGPEeGETATFIYVGRMKFEgqKRVKDLLDGLSQA-QGDWKLHVLGDGSDFEK 222
Cdd:cd03823 158 HEANGLFSARISVIPNAVEPdlAPPPRRRPG-TERLRFGYIGRLTEE--KGIDLLVEAFKRLpREDIELVIAGHGPLSDE 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 223 cqaygRELKIDNRIVWHGwqKHPWEVVRQDIKKVSALLLTSSF-EGFPMTLLESMSWGIPCISADcVSGPGDIIQPDVNG 301
Cdd:cd03823 235 -----RQIEGGRRIAFLG--RVPTDDIKDFYEKIDVLVVPSIWpEPFGLVVREAIAAGLPVIASD-LGGIAELIQPGVNG 306
|
250
....*....|..
gi 446606624 302 HLYQPGDIAGFV 313
Cdd:cd03823 307 LLFAPGDAEDLA 318
|
|
| GT4_GtfA-like |
cd04949 |
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ... |
181-309 |
2.24e-15 |
|
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.
Pssm-ID: 340855 [Multi-domain] Cd Length: 328 Bit Score: 76.19 E-value: 2.24e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 181 FIYVGRMKFEgqKRVKDLLDGLSQAQG---DWKLHVLGDGSDFEKCQAYGRELKIDNRIVWHGWQKHPwevvRQDIKKVS 257
Cdd:cd04949 163 IITISRLAPE--KQLDHLIEAVAKAVKkvpEITLDIYGYGEEREKLKKLIEELHLEDNVFLKGYHSNL----DQEYQDAY 236
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 446606624 258 ALLLTSSFEGFPMTLLESMSWGIPCISADCVSGPGDIIQPDVNGHLYQPGDI 309
Cdd:cd04949 237 LSLLTSQMEGFGLTLMEAIGHGLPVVSYDVKYGPSELIEDGENGYLIEKNNI 288
|
|
| RfaB |
COG0438 |
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ... |
240-321 |
4.88e-13 |
|
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440207 [Multi-domain] Cd Length: 123 Bit Score: 65.01 E-value: 4.88e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 240 GWQKHPWEVVRQDIKKVSALLLTSSFEGFPMTLLESMSWGIPCISADcVSGPGDIIQPDVNGHLYQPGDIAGFVTLLNKY 319
Cdd:COG0438 5 VPRKGLDLLLEALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATD-VGGLPEVIEDGETGLLVPPGDPEALAEAILRL 83
|
..
gi 446606624 320 IA 321
Cdd:COG0438 84 LE 85
|
|
| GT4_UGDG-like |
cd03817 |
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ... |
117-341 |
5.94e-12 |
|
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.
Pssm-ID: 340844 [Multi-domain] Cd Length: 372 Bit Score: 66.15 E-value: 5.94e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 117 HFSLDHKKHAEYITCAdyhlaiSSGIKQQMINRGVpESTINVIFNPVE-AKDTVIPGPEEGETATF-------IYVGRMK 188
Cdd:cd03817 139 KLVRRFYNHTDAVIAP------SEKIKDTLREYGV-KGPIEVIPNGIDlDKFEKPLNTEERRKLGLppdepilLYVGRLA 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 189 FEgqKRVKDLLDGLSQ--AQGDWKLHVLGDGSDFEKCQAYGRELKIDNRIVWHGWqkHPWEVVRQDIKKVSALLLTSSFE 266
Cdd:cd03817 212 KE--KNIDFLLRAFAElkKEPNIKLVIVGDGPEREELKELARELGLADKVIFTGF--VPREELPEYYKAADLFVFASTTE 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 267 GFPMTLLESMSWGIP--CISADCVSgpgDIIQPDVNGHLYQPGDIAgFVTLLNKYIA-----------GEIHIEHEKIPA 333
Cdd:cd03817 288 TQGLVYLEAMAAGLPvvAAKDPAAS---ELVEDGENGFLFEPNDET-LAEKLLHLREnlellrklsknAEISAREFAFAK 363
|
....*...
gi 446606624 334 SIDKFYQS 341
Cdd:cd03817 364 SVEKLYEE 371
|
|
| GT4_WbuB-like |
cd03794 |
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ... |
74-313 |
2.95e-11 |
|
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.
Pssm-ID: 340825 [Multi-domain] Cd Length: 391 Bit Score: 64.29 E-value: 2.95e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 74 HALSKWLQDYQPDVVICID------VISCLYAAKARKK-----------SGIDVPVFSWPHFSLDHKKHAEYIT-CADYH 135
Cdd:cd03794 88 ALLKLLVREERPDVIIAYSppitlgLAALLLKKLRGAPfildvrdlwpeSLIALGVLKKGSLLKLLKKLERKLYrLADAI 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 136 LAISSGIKQQMINRGVPESTINVI--------FNPVEAKDTVIPGPEEGETaTFIYVGRM-KFEGQKRVKDLLDGLSQaQ 206
Cdd:cd03794 168 IVLSPGLKEYLLRKGVPKEKIIVIpnwadleeFKPPPKDELRKKLGLDDKF-VVVYAGNIgKAQGLETLLEAAERLKR-R 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 207 GDWKLHVLGDGSDFEKCQAYGRELKIDNrIVWHGWQkhPWEVVRQDIKKVSALLLT-----SSFEGFPMTLLESMSWGIP 281
Cdd:cd03794 246 PDIRFLFVGDGDEKERLKELAKARGLDN-VTFLGRV--PKEEVPELLSAADVGLVPlkdnpANRGSSPSKLFEYMAAGKP 322
|
250 260 270
....*....|....*....|....*....|..
gi 446606624 282 cISADCVSGPGDIIQPDVNGHLYQPGDIAGFV 313
Cdd:cd03794 323 -ILASDDGGSDLAVEINGCGLVVEPGDPEALA 353
|
|
| GT4_MtfB-like |
cd03809 |
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ... |
9-286 |
2.43e-10 |
|
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.
Pssm-ID: 340838 [Multi-domain] Cd Length: 362 Bit Score: 61.23 E-value: 2.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 9 AVSGFGGMETVIRDVITTFrQQHIYSEMFFFCRNDKMDkgwlEGIKYSCSFSNIRLGFLRRAKHIHALSKWLQDY----- 83
Cdd:cd03809 9 LAQRLTGIGRYTRELLKAL-AKNDPDESVLAVPPLPGE----LLRLLREYPELSLGVIKIKLWRELALLRWLQILlpkkd 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 84 QPDVVICIDVISCLYAAKARKKSGI-DVPVFSWPH-FSLDHKKHAEYIT-----CADYHLAISSGIKQQMINR-GVPEST 155
Cdd:cd03809 84 KPDLLHSPHNTAPLLLKGCPQVVTIhDLIPLRYPEfFPKRFRLYYRLLLpislrRADAIITVSEATRDDIIKFyGVPPEK 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 156 INVIFNPVEAKDTVIPGPEEGETA------TFIYVGRmkFEGQKRVKDLLDGLSQAQGDWKLHVL----GDGSDFEKCQA 225
Cdd:cd03809 164 IVVIPLGVDPSFFPPESAAVLIAKyllpepYFLYVGT--LEPRKNHERLLKAFALLKKQGGDLKLvivgGKGWEDEELLD 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446606624 226 YGRELKIDNRIVWHGWqkhpweVVRQDIKKV----SALLLTSSFEGFPMTLLESMSWGIPCISAD 286
Cdd:cd03809 242 LVKKLGLGGRVRFLGY------VSDEDLPALyrgaRAFVFPSLYEGFGLPVLEAMACGTPVIASN 300
|
|
| GT4_BshA-like |
cd04962 |
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ... |
107-312 |
6.42e-10 |
|
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.
Pssm-ID: 340859 [Multi-domain] Cd Length: 370 Bit Score: 60.06 E-value: 6.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 107 GIDVPVFSWPHFSLDHKKHAeyITCADYHLAISSGIKQQMINRGVPESTINVIFNPV-EAKDTVIPGPE--------EGE 177
Cdd:cd04962 119 GTDITLVGYDPSLQPAVRFS--INKSDRVTAVSSSLRQETYELFDVDKDIEVIHNFIdEDVFKRKPAGAlkrrllapPDE 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 178 tATFIYVGrmKFEGQKRVKDLLDGLSQAQGDW--KLHVLGDGSDFEKCQAYGRELKIDNRIVWHGWQKHPwevvrQDIKK 255
Cdd:cd04962 197 -KVVIHVS--NFRPVKRIDDVVRVFARVRRKIpaKLLLVGDGPERVPAEELARELGVEDRVLFLGKQDDV-----EELLS 268
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 446606624 256 VSAL-LLTSSFEGFPMTLLESMSWGIPCISADcVSGPGDIIQPDVNGHLYQPGDIAGF 312
Cdd:cd04962 269 IADLfLLPSEKESFGLAALEAMACGVPVVSSN-AGGIPEVVKHGETGFLSDVGDVDAM 325
|
|
| Glyco_transf_4 |
pfam13439 |
Glycosyltransferase Family 4; |
14-163 |
2.20e-09 |
|
Glycosyltransferase Family 4;
Pssm-ID: 463877 [Multi-domain] Cd Length: 169 Bit Score: 56.00 E-value: 2.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 14 GGMETVIRDVITTFRQQHIYSEMFFFCRNDKMDKGWLEGIKYSCSFSNIRLGFLRRAKHIHALSKWLQDYQPDVVICIDV 93
Cdd:pfam13439 1 GGVERYVLELARALARRGHEVTVVTPGGPGPLAEEVVRVVRVPRVPLPLPPRLLRSLAFLRRLRRLLRRERPDVVHAHSP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 94 ISCLYAAKARKKSGiDVPVFSWPHFSLDHKKHAEY----------------ITCADYHLAISSGIKQQMINR-GVPESTI 156
Cdd:pfam13439 81 FPLGLAALAARLRL-GIPLVVTYHGLFPDYKRLGArlsplrrllrrlerrlLRRADRVIAVSEAVADELRRLyGVPPEKI 159
|
....*..
gi 446606624 157 NVIFNPV 163
Cdd:pfam13439 160 RVIPNGV 166
|
|
| GT4-like |
cd05844 |
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ... |
136-310 |
2.37e-09 |
|
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.
Pssm-ID: 340860 [Multi-domain] Cd Length: 365 Bit Score: 58.23 E-value: 2.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 136 LAISSGIKQQMINRGVPESTINVIFNPVEAkDTVIPGPEEGETATFIYVGRmkFEGQKRVKDLLDG---LSQAQGDWKLH 212
Cdd:cd05844 148 VAVSGFIRDRLLARGLPAERIHVHYIGIDP-AKFAPRDPAERAPTILFVGR--LVEKKGCDVLIEAfrrLAARHPTARLV 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 213 VLGDGSDFEKCQAYGRELkidNRIVWHGWQKHPweVVRQDIKKVSALLLTS------SFEGFPMTLLESMSWGIPCISAD 286
Cdd:cd05844 225 IAGDGPLRPALQALAAAL---GRVRFLGALPHA--EVQDWMRRAEIFCLPSvtaasgDSEGLGIVLLEAAACGVPVVSSR 299
|
170 180
....*....|....*....|....
gi 446606624 287 cVSGPGDIIQPDVNGHLYQPGDIA 310
Cdd:cd05844 300 -HGGIPEAILDGETGFLVPEGDVD 322
|
|
| GT4-like |
cd03814 |
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ... |
60-316 |
5.79e-09 |
|
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.
Pssm-ID: 340842 [Multi-domain] Cd Length: 365 Bit Score: 56.92 E-value: 5.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 60 SNIRLGFLRRAKHIHALskwlQDYQPDVV-ICIDVISCLYAAKARKKSGIDV-----------------PVFSWPHFSLD 121
Cdd:cd03814 64 PEYRLALPLPRRVRRLI----KEFQPDIIhIATPGPLGLAALRAARRLGLPVvtsyhtdfpeylsyytlGPLSWLAWAYL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 122 HKKHAeyitCADYHLAISSGIKQQMINRGVPestiNV----------IFNPVEAKDTVIPGPEEGETATFIYVGRMKFEg 191
Cdd:cd03814 140 RWFHN----PFDTTLVPSPSIARELEGHGFE----RVrlwprgvdteLFHPSRRDAALRRRLGPPGRPLLLYVGRLAPE- 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 192 qKRVKDLLDGLS--QAQGDWKLHVLGDGSDFEKCQAYGRElkidnrIVWHGWQKhpwevvRQDIKKVSA----LLLTSSF 265
Cdd:cd03814 211 -KNLEALLDADLplAASPPVRLVVVGDGPARAELEARGPD------VIFTGFLT------GEELARAYAsadvFVFPSRT 277
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 446606624 266 EGFPMTLLESMSWGIPCISADcVSGPGDIIQPDVNGHLYQPGDIAGFVTLL 316
Cdd:cd03814 278 ETFGLVVLEAMASGLPVVAAD-AGGPRDIVRPGGTGALVEPGDAAAFAAAL 327
|
|
| GT4_CapH-like |
cd03812 |
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ... |
143-289 |
8.10e-09 |
|
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).
Pssm-ID: 340840 [Multi-domain] Cd Length: 357 Bit Score: 56.53 E-value: 8.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 143 KQQMINRGVPesTINVIFNPVEAKDTVIPGPEEGETAtFIYVGRMKFE-GQKRVKDLLDGLSQAQGDWKLHVLGDGSDFE 221
Cdd:cd03812 159 KFKVIPNGID--IEKYKFNKEKRRKRRKLLILEDKLV-LGHVGRFNEQkNHSFLIDIFEELKKKNPNVKLVLVGEGELKE 235
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446606624 222 KCQAYGRELKIDNRIVWHGwqkhpwevVRQDIKK-VSA---LLLTSSFEGFPMTLLESMSWGIPCISADCVS 289
Cdd:cd03812 236 KIKEKVKELGLEDKVIFLG--------FRNDVSEiLSAmdvFLFPSLYEGLPLVAVEAQASGLPCLLSDTIT 299
|
|
| GT4_Bme6-like |
cd03821 |
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ... |
84-317 |
1.41e-08 |
|
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.
Pssm-ID: 340848 [Multi-domain] Cd Length: 377 Bit Score: 55.84 E-value: 1.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 84 QPDVVICIDVIS--CLYAAKARKKSGIdvPVFSWPHFSLDH--------KKHAEYITCADYHLAISSGIK------QQMI 147
Cdd:cd03821 90 EYDVVHIHGVWTytSLAACKLARRRGI--PYVVSPHGMLDPwalqqkhwKKRIALHLIERRNLNNAALVHftseqeADEL 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 148 NRGVPESTINVIFNPVEAkDTVIPGPEEG------ETATFI-YVGRMkfEGQKRVKDLLDG---LSQAQGDWKLHVLG-D 216
Cdd:cd03821 168 RRFGLEPPIAVIPNGVDI-PEFDPGLRDRrkhnglEDRRIIlFLGRI--HPKKGLDLLIRAarkLAEQGRDWHLVIAGpD 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 217 GSDFEKCQAYGRELKIDNRIVWHGwqkhpweVVRQDIKkvSALL-------LTSSFEGFPMTLLESMSWGIPCisadcvs 289
Cdd:cd03821 245 DGAYPAFLQLQSSLGLGDRVTFTG-------PLYGEAK--WALYasadlfvLPSYSENFGNVVAEALACGLPV------- 308
|
250 260
....*....|....*....|....*....
gi 446606624 290 gpgdIIQPDVNGH-LYQPGDiaGFVTLLN 317
Cdd:cd03821 309 ----VITDKCGLSeLVEAGC--GVVVDPN 331
|
|
| PRK15179 |
PRK15179 |
Vi polysaccharide biosynthesis protein TviE; Provisional |
150-309 |
3.14e-08 |
|
Vi polysaccharide biosynthesis protein TviE; Provisional
Pssm-ID: 185101 [Multi-domain] Cd Length: 694 Bit Score: 55.43 E-value: 3.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 150 GVPESTINVIFNPV-------EAKDTVIPGPEEGET--ATFIYVGRMKFEGQKRVKDLLDGLSQ---AQGDWKLHVLGDG 217
Cdd:PRK15179 478 GVDERRIPVVYNGLaplksvqDDACTAMMAQFDARTsdARFTVGTVMRVDDNKRPFLWVEAAQRfaaSHPKVRFIMVGGG 557
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 218 SDFEKCQAYGRELKIDNRIVWHGWQKHpwevVRQDIKKVSALLLTSSFEGFPMTLLESMSWGIPCISAdCVSGPGDIIQP 297
Cdd:PRK15179 558 PLLESVREFAQRLGMGERILFTGLSRR----VGYWLTQFNAFLLLSRFEGLPNVLIEAQFSGVPVVTT-LAGGAGEAVQE 632
|
170
....*....|..
gi 446606624 298 DVNGHLYQPGDI 309
Cdd:PRK15179 633 GVTGLTLPADTV 644
|
|
| GT4_WcaC-like |
cd03825 |
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ... |
266-309 |
8.03e-07 |
|
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.
Pssm-ID: 340851 [Multi-domain] Cd Length: 364 Bit Score: 50.41 E-value: 8.03e-07
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 446606624 266 EGFPMTLLESMSWGIPCISADcVSGPGDIIQPDVNGHLYQPGDI 309
Cdd:cd03825 274 DNLPNTLLEAMACGTPVVAFD-TGGSPEIVQHGVTGYLVPPGDV 316
|
|
| GT4-like |
cd03813 |
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ... |
150-286 |
5.98e-06 |
|
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.
Pssm-ID: 340841 [Multi-domain] Cd Length: 474 Bit Score: 47.71 E-value: 5.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 150 GVPESTINVIFNPVEAKD--TVIPGPEEGETATFIYVGRMKfegqkRVKDL------LDGLSQAQGDWKLHVLG---DGS 218
Cdd:cd03813 263 GADPDKTRVIPNGIDIQRfaPAREERPEKEPPVVGLVGRVV-----PIKDVktfiraFKLVRRAMPDAEGWLIGpedEDP 337
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446606624 219 DFEK-CQAYGRELKIDNRIVWHGwqkhpwevvRQDIK----KVSALLLTSSFEGFPMTLLESMSWGIPCISAD 286
Cdd:cd03813 338 EYAQeCKRLVASLGLENKVKFLG---------FQNIKeyypKLGLLVLTSISEGQPLVILEAMASGVPVVATD 401
|
|
| Glyco_trans_4_4 |
pfam13579 |
Glycosyl transferase 4-like domain; |
63-159 |
7.05e-06 |
|
Glycosyl transferase 4-like domain;
Pssm-ID: 433325 [Multi-domain] Cd Length: 158 Bit Score: 45.47 E-value: 7.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 63 RLGFLRRAKHIHALSKWLQDYQPDVVICIDVISCLYAAKARKKSGIDVpVFSWPHFSLDHKKHAEY----------ITCA 132
Cdd:pfam13579 50 RPSPLADLAALRRLRRLLRAERPDVVHAHSPTAGLAARLARRRRGVPL-VVTVHGLALDYGSGWKRrlaralerrlLRRA 128
|
90 100
....*....|....*....|....*..
gi 446606624 133 DYHLAISSGIKQQMINRGVPESTINVI 159
Cdd:pfam13579 129 DAVVVVSEAEAELLRALGVPAARVVVV 155
|
|
| GT4_sucrose_synthase |
cd03800 |
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ... |
262-311 |
1.17e-04 |
|
sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.
Pssm-ID: 340830 [Multi-domain] Cd Length: 398 Bit Score: 43.77 E-value: 1.17e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 446606624 262 TSSFEGFPMTLLESMSWGIPCISAdCVSGPGDIIQPDVNGHL---YQPGDIAG 311
Cdd:cd03800 309 PSLYEPFGLTAIEAMACGTPVVAT-AVGGLQDIVRDGRTGLLvdpHDPEALAA 360
|
|
| GT4_AmsK-like |
cd03799 |
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ... |
92-323 |
2.11e-04 |
|
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.
Pssm-ID: 340829 [Multi-domain] Cd Length: 350 Bit Score: 42.82 E-value: 2.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 92 DVISCLY------AAKARKKSGID---VPVF-----SWPHfSLDHKKHAEYI-TCADYHLAISSGIKQQMINRGVPESTI 156
Cdd:cd03799 72 DIIHCQFgplgalGALLRRLKVLKgklVTSFrgydiSMYV-ILEGNKVYPQLfAQGDLFLPNCELFKHRLIALGCDEKKI 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 157 NVIFNPVEA-----KDTVIPGPEEGETATfiyVGRM-KFEGQKRVKDLLDGLSQAQGDWKLHVLGDGSDFEKCQAYGREL 230
Cdd:cd03799 151 IVHRSGIDCnkfrfKPRYLPLDGKIRILT---VGRLtEKKGLEYAIEAVAKLAQKYPNIEYQIIGDGDLKEQLQQLIQEL 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 231 KIDNRIVWHGWQKHPwEVVRqdIKKVSALLLTSSF-------EGFPMTLLESMSWGIPCISADCvSGPGDIIQPDVNGHL 303
Cdd:cd03799 228 NIGDCVKLLGWKPQE-EIIE--ILDEADIFIAPSVtaadgdqDGPPNTLKEAMAMGLPVISTEH-GGIPELVEDGVSGFL 303
|
250 260
....*....|....*....|
gi 446606624 304 YQPGDIAGFVTLLNKYIAGE 323
Cdd:cd03799 304 VPERDAEAIAEKLTYLIEHP 323
|
|
| PLN02871 |
PLN02871 |
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase |
175-316 |
2.33e-04 |
|
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
Pssm-ID: 215469 [Multi-domain] Cd Length: 465 Bit Score: 42.78 E-value: 2.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 175 EGETATFIYVGRMKFEgqKRVKDLLDGLSQAQGDwKLHVLGDGSDFEKCQAY-------------GRELKidnrivwhgw 241
Cdd:PLN02871 260 EPEKPLIVYVGRLGAE--KNLDFLKRVMERLPGA-RLAFVGDGPYREELEKMfagtptvftgmlqGDELS---------- 326
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446606624 242 qkhpwevvrQDIKKVSALLLTSSFEGFPMTLLESMSWGIPCISADcVSGPGDIIQPD---VNGHLYQPGDIAGFVTLL 316
Cdd:PLN02871 327 ---------QAYASGDVFVMPSESETLGFVVLEAMASGVPVVAAR-AGGIPDIIPPDqegKTGFLYTPGDVDDCVEKL 394
|
|
| PRK13609 |
PRK13609 |
diacylglycerol glucosyltransferase; Provisional |
76-216 |
3.85e-03 |
|
diacylglycerol glucosyltransferase; Provisional
Pssm-ID: 237445 [Multi-domain] Cd Length: 380 Bit Score: 38.94 E-value: 3.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446606624 76 LSKWLQDYQPDVVICIDVISCLyaAKARKKSGIDVPVFS----------WPHFSLDhkkhaEYITCADYhlaissgIKQQ 145
Cdd:PRK13609 96 LKLLLQAEKPDIVINTFPIIAV--PELKKQTGISIPTYNvltdfclhkiWVHREVD-----RYFVATDH-------VKKV 161
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446606624 146 MINRGVPESTINVIFNPVEakdtviPGPEEGETATFIYvGRMKFEGQKRVKDLLDGlsqAQGdwklhVLGD 216
Cdd:PRK13609 162 LVDIGVPPEQVVETGIPIR------SSFELKINPDIIY-NKYQLCPNKKILLIMAG---AHG-----VLGN 217
|
|
| GT4_AmsK-like |
cd04946 |
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most ... |
263-303 |
6.75e-03 |
|
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. The members of this family are found mainly in bacteria and Archaea.
Pssm-ID: 340854 [Multi-domain] Cd Length: 401 Bit Score: 38.21 E-value: 6.75e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 446606624 263 SSFEGFPMTLLESMSWGIPCIsADCVSGPGDIIQPDVNGHL 303
Cdd:cd04946 312 SESEGIPVSIMEAISFGIPVI-ATNVGGTREIVENETNGLL 351
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