|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
1-467 |
0e+00 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 975.27 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 1 MKFWRPGITGKLFLAIFATCIVLLISMHWAVRISFERGFIDYIKHGNEQRLQLLSDALGEQYAQHGNWRFLRNNDRFVFQ 80
Cdd:PRK10549 1 MKFWRPGITGKLFLAIFATCMLVLITMHWGVRISFERGFIDYIKHGNEQRLQMLSDALGEQYQQHGNWRFLRNNDRFVFQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 81 ILRSFEHdNSEDKPGPGMPPHGWRTQFWVVDQNNKVLVGPRAPIPPDGTRRPILVNGAEVGAVIASPVERLTRNTDINFD 160
Cdd:PRK10549 81 ILRSFEQ-DNDSKPGPGMPPHGWRTQFWVVDQNNKVLVGPRGPIPPDGTRRPILVNGAEVGWVIASPVERLTRNTDINFD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 161 RQQRQTSWLIVALSTLLAALATFPLARGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTLEKNQQM 240
Cdd:PRK10549 160 KQQRRTSWLIVALSTLLAALATFLLARGLLAPVKRLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFNQLASTLEKNEQM 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 241 RRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPETVASLQAEVGTLTKLVDDLHQLSMSDEGALAYQKSSVDLIPLLE 320
Cdd:PRK10549 240 RRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPESVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKTPVDLVPLLE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 321 VAGGAFRERFASRGLKLQFSLPDSITVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISAEQHDKTVRLTFADSAPGVSDD 400
Cdd:PRK10549 320 VAGGAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDE 399
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446597808 401 QLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQREV 467
Cdd:PRK10549 400 QLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQREV 466
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
4-458 |
0e+00 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 826.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 4 WRPGITGKLFLAIFATCIVLLISMHWAVRISFERGFIDYIKHGNEQRLQLLSDALGEQYAQHGNWRFLRNN-DRFVFQIL 82
Cdd:NF012163 1 LRPGITGKLFLAIFATCLLLLIVMHWAVRVSFQRGFIDYIKDGNEQRLQRLSDALGEQYAQHGNWRFLRNNgDRWVRQLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 83 RSFEHDNSEDKPGPGMPPH-GWRTQFWVVDQNNKVLVGPRAPIPPDGTRRPILVNGAEVGAVIASPVERLTRNTDINFDR 161
Cdd:NF012163 81 RTLEHDNDSDKPGPGLPDHlGWRSRLWLVDANHRFVVGPPDPVSDDGTRRPILVNGQEVGALGASPVERLTRNTDINFDS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 162 QQRQTSWLIVALSTLLAALATFPLARGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTLEKNQQMR 241
Cdd:NF012163 161 QQKRASWLIVALALLLAALAAFLLARGLLAPVKRLVEATHRLAAGDYTTRVTPTSNDELGKLAQDFNQLASTLEKNEQMR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 242 RDFMADISHELRTPLAVLRGELEAIQDGVRKFTPETVASLQAEVGTLTKLVDDLHQLSMSDEGALAYQKSSVDLIPLLEV 321
Cdd:NF012163 241 RDFMADISHELRTPLAVLRAELEAIQDGIRKFTPESLDSLQAEVGTLTKLVDDLHDLSMSDEGALAYQKASVDLVPLLEV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 322 AGGAFRERFASRGLKLQFSLPDSITVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISAEQHDKTVRLTFADSAPGVSDDQ 401
Cdd:NF012163 321 EGGAFRERFASAGLELEVSLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISASQRPKEVTLTVADSAPGVSDEQ 400
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 446597808 402 LQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELP 458
Cdd:NF012163 401 LARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTLP 457
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
133-462 |
2.12e-84 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 264.88 E-value: 2.12e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 133 ILVNGAEVGAVIASPVERLTRNTDINFDRQQRQTSWLIVALSTLLAALATFPLARGLLAPVKRLVDGTHKLAAGDFTTRV 212
Cdd:COG5002 61 LLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSA 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 213 TPTSEDELGKLAQDFNQLastlEKNQQMRRDFMADISHELRTPLAVLRGELEAIQDGVRKFTP---ETVASLQAEVGTLT 289
Cdd:COG5002 141 LLLGLLLLAAVERDITEL----ERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEerrEYLEIILEEAERLS 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 290 KLVDDLHQLSMSDEGALAYQKSSVDLIPLLEVAGGAFRERFASRGLKLQFSLP-DSITVFGDRDRLMQLFNNLLENSLRY 368
Cdd:COG5002 217 RLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPeDPLLVLGDPDRLEQVLTNLLDNAIKY 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 369 TDSGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPF 448
Cdd:COG5002 297 TPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPG 376
|
330
....*....|....
gi 446597808 449 GGVSITVELPLERD 462
Cdd:COG5002 377 KGTTFTITLPLARE 390
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
133-460 |
1.14e-69 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 224.79 E-value: 1.14e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 133 ILVNGAEVGAVIASPVERLTRNTDINFDRQQRQTSWLIVALSTLLAALATFPLARGLLAPVKRLVDGTHKLAAGDFTTRV 212
Cdd:COG0642 2 LLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 213 TPTSEDELGKLAQDFNQLASTLEKNQQMRRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPETVASLQAEVGTLTKLV 292
Cdd:COG0642 82 LLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLETILRSADRLLRLI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 293 DDLHQLSMSDEGALAYQKSSVDLIPLLEVAGGAFRERFASRGLKLQFSLPDSI-TVFGDRDRLMQLFNNLLENSLRYTDS 371
Cdd:COG0642 162 NDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLpTVRGDPDRLRQVLLNLLSNAIKYTPE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 372 GGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNraSGGSGLGLAICLNIVEAHNGRIIAAHSPFGGV 451
Cdd:COG0642 242 GGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRR--GGGTGLGLAIVKRIVELHGGTIEVESEPGKGT 319
|
....*....
gi 446597808 452 SITVELPLE 460
Cdd:COG0642 320 TFTVTLPLA 328
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
228-461 |
2.40e-66 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 212.84 E-value: 2.40e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 228 NQLASTLEKNQQMRRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPET---VASLQAEVGTLTKLVDDLHQLSMSDEG 304
Cdd:COG2205 3 EEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERrelLEIIRESAERLLRLIEDLLDLSRLESG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 305 ALAYQKSSVDLIPLLEVAGGAFRERFASRGLKLQFSLP-DSITVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISAEQHD 383
Cdd:COG2205 83 KLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPpELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREG 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446597808 384 KTVRLTFADSAPGVSDDQLQKLFERFYRteGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLER 461
Cdd:COG2205 163 DGVRISVSDNGPGIPEEELERIFERFYR--GDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAE 238
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-458 |
6.19e-66 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 207.32 E-value: 6.19e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 350 DRDRLMQLFNNLLENSLRYTDSGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRASGGSGLGLAI 429
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 446597808 430 CLNIVEAHNGRIIAAHSPFGGVSITVELP 458
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
183-459 |
1.94e-51 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 177.49 E-value: 1.94e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 183 FPLARGLLAPVKRLVDGTHKLAAGDFTTRV--TPTSEDELGKLAQDFNQLASTLE---KNQQMrrdFMADISHELRTPLA 257
Cdd:NF012226 78 MKLAQRFIVPINFLADAAKKISQGDLSARAedSQIHSAEISELMHNFNDMAQKLEssvKNAQV---WNAAIAHELRTPIT 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 258 VLRGELEAIQDGVRKFTPETVASLQAEVGTLTKLVDDLHQLSMSDEGALAYQKSSVDLIPLLEVAGGAFRERFASRGLKL 337
Cdd:NF012226 155 ILQGRLQGILDGVFEPDPALFKSLLNQVEGLSHLVEDLRTLSLVENQQLRLNYESVDLKDSIEKVLKMFEDRLEQAQLTI 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 338 QFSLPDSiTVFGDRDRLMQLFNNLLENSLRYTDSgGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRN 417
Cdd:NF012226 235 VLNLTAT-PVFCDRRRIEQVLIALIDNAIRYANA-GKLKISSSVIQDDWILQIEDEGPGIAEEYQQDLFNPFFRLEQSRN 312
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 446597808 418 RASGGSGLGLAICLNIVEAHNGRIiaAHSPFGGVSI-TVELPL 459
Cdd:NF012226 313 KEFGGTGLGLAVVHAIVIAHKGSI--EYSNSQGNSVfTIKLPA 353
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
208-442 |
5.99e-48 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 167.77 E-value: 5.99e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 208 FTTRVTPTSEDELGKLAQDFNQLASTleknQQMRRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPE---TVASLQAE 284
Cdd:TIGR02966 85 LEIRIAPYGEEQKLLVARDVTRLRRL----EQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEwnrALEIMLEQ 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 285 VGTLTKLVDDLHQLSMSDEGALAYQKSSVDLIPLLEVAGGAFRERFASRGLKLQFSLPDSITVFGDRDRLMQLFNNLLEN 364
Cdd:TIGR02966 161 SQRMQSLVEDLLTLSRLESAASPLEDEPVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVDVLGDEDELRSAFSNLVSN 240
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446597808 365 SLRYTDSGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRII 442
Cdd:TIGR02966 241 AIKYTPEGGTITVRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLE 318
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
121-458 |
1.81e-40 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 150.62 E-value: 1.81e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 121 RAPIPPDGTRRPILVNGAEVGAVIASPVERLTRNTDINFD----RQQRQTSWLIVALSTLLAALATFPLARGLLAPVKRL 196
Cdd:TIGR01386 116 DQADAKMTHYRSILRSVAALPGGKGRKPVQITVALDINAHthllDALRKWLILIAVLLVLLTALLGWWITRLGLEPLRRL 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 197 VDGTHKLAAGDFTTRVTPT-SEDELGKLAQDFNQLASTLEKNQQMRRDFMADISHELRTPLAVLRGELEAI--QDGVRKF 273
Cdd:TIGR01386 196 SAVAARISPESLDQRLDPSrAPAELRELAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLTNLLGQTQVAlsQPRTGEE 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 274 TPETVASLQAEVGTLTKLVDDLHQLSMSDEGALAYQKSSVDLIPLLEVAGGAFRERFASRGLKLQFSlpDSITVFGDRDR 353
Cdd:TIGR01386 276 YREVLESNLEELERLSRMVSDMLFLARADNGQLALERVRLDLAAELAKVAEYFEPLAEERGVRIRVE--GEGLVRGDPQM 353
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 354 LMQLFNNLLENSLRYTDSGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRASGGSGLGLAICLNI 433
Cdd:TIGR01386 354 FRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSI 433
|
330 340
....*....|....*....|....*
gi 446597808 434 VEAHNGRiIAAHSPFGGVSITVELP 458
Cdd:TIGR01386 434 MEAHGGR-ASAESPDGKTRFILRFP 457
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
235-459 |
7.29e-40 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 151.44 E-value: 7.29e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 235 EKNQQMRRDFMADISHELRTPLAVLRGELEAIQDGV---RKFTPETVASLQAEVGTLTKLVDDLHQLSMSDEGALAYQKS 311
Cdd:NF033092 366 EKIEQERREFVANVSHELRTPLTTMRSYLEALADGAwkdPELAPRFLGVTQNETERMIRLVNDLLQLSRMDSKDYKLNKE 445
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 312 SVDLIPLL-EVAggafrERF----ASRGLKLQFSLPD-SITVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISAEQHDKT 385
Cdd:NF033092 446 WVNFNEFFnYII-----DRFemilKNKNITFKREFPKrDLWVEIDTDKITQVLDNIISNAIKYSPEGGTITFRLLETHNR 520
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446597808 386 VRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRiIAAHSPFG-GVSITVELPL 459
Cdd:NF033092 521 IIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGGTGLGLAIAKEVVEAHGGR-IWAESEEGkGTTIYFTLPY 594
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
186-462 |
1.89e-39 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 149.02 E-value: 1.89e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 186 ARGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLAST-------LEKNQQMRRDFMADISHELRTPLAV 258
Cdd:NF040691 209 TRQVVAPVRSAARTAERFAAGDLSERMPVKGEDDLARLARSFNQMADSlqrqirqLEELSRLQQRFVSDVSHELRTPLTT 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 259 LRGELEAIQDGVRKFTPETVAS---LQAEVGTLTKLVDDLHQLSMSDEGALAYQKSSVDLIPLLEVAGGAFRERFASRGL 335
Cdd:NF040691 289 IRMAADVIHDSRDDFDPATARSaelLHTELDRFESLLSDLLEISRFDAGAAELDVEPVDLRPLVRRVVDALRQLAERAGV 368
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 336 KLQFSLPDS-ITVFGDRDRLMQLFNNLLENSLRYTDsGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEG 414
Cdd:NF040691 369 ELRVDAPGTpVVAEVDPRRVERVLRNLVVNAIEHGE-GKPVVVTVAQDDTAVAVTVRDHGVGLKPGEVALVFDRFWRADP 447
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 446597808 415 SRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERD 462
Cdd:NF040691 448 ARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLTLPRVAG 495
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
185-462 |
1.26e-38 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 145.10 E-value: 1.26e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 185 LARGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTLEK---------------------------- 236
Cdd:COG5000 29 LARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEqreeleerrryletilenlpagvivlda 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 237 -------NQQMRR------------------------------------------------------------------- 242
Cdd:COG5000 109 dgritlaNPAAERllgipleeligkpleellpeldlaellrealergwqeeieltrdgrrtllvrasplrddgyvivfdd 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 243 --------------DFMADISHELRTPLAVLRGELEAIQDGVRKFTPETVASLQA-------EVGTLTKLVDDLHQLS-M 300
Cdd:COG5000 189 itellraerlaawgELARRIAHEIKNPLTPIQLSAERLRRKLADKLEEDREDLERaldtiirQVDRLKRIVDEFLDFArL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 301 SdegalAYQKSSVDLIPLLEVAGGAFRERFASRGLKLQFSLPDSI-TVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISA 379
Cdd:COG5000 269 P-----EPQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLpEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVST 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 380 EQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTegsrnrASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPL 459
Cdd:COG5000 344 RREDGRVRIEVSDNGPGIPEEVLERIFEPFFTT------KPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPL 417
|
...
gi 446597808 460 ERD 462
Cdd:COG5000 418 AEE 420
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
185-459 |
4.35e-38 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 144.30 E-value: 4.35e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 185 LARGLLAPVKRLVDGTHKLAAGDFttRVTPTSED---ELGKLAQDFNQLASTLEK---NQQMrrdFMADISHELRTPLAV 258
Cdd:PRK09470 186 LAWSLAKPARKLKNAADEVAQGNL--RQHPELETgpqEFRQAGASFNQMVTALERmmtSQQR---LLSDISHELRTPLTR 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 259 LR-------------GELEAIqdgvrkftpETvaslqaEVGTLTKLVDDLHQLS-MSDEGALAYQKSSVDLI--PLLEVA 322
Cdd:PRK09470 261 LQlatallrrrqgesKELERI---------ET------EAQRLDSMINDLLVLSrNQQKNHLERETFKANSLwsEVLEDA 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 323 ggafreRF--ASRGLKLQFSL-PDSITVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISAEQHDKTVRLTfaDSAPGVSD 399
Cdd:PRK09470 326 ------KFeaEQMGKSLTVSApPGPWPINGNPNALASALENIVRNALRYSHTKIEVAFSVDKDGLTITVD--DDGPGVPE 397
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 400 DQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPL 459
Cdd:PRK09470 398 EEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLPL 457
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
185-459 |
1.54e-36 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 138.01 E-value: 1.54e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 185 LARGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTLEKNQQMRRDFM------------ADISHEL 252
Cdd:COG4191 74 GLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVqseklaalgelaAGIAHEI 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 253 RTPLAVLRGELEAIQDGVRKF-----TPETVASLQAEVGTLTKLVDDLHQLSMSDEGalayQKSSVDLIPLLEVAGGAFR 327
Cdd:COG4191 154 NNPLAAILGNAELLRRRLEDEpdpeeLREALERILEGAERAAEIVRSLRAFSRRDEE----EREPVDLNELIDEALELLR 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 328 ERFASRGLKLQFSLPDSI-TVFGDRDRLMQLFNNLLENSLrytD-----SGGSLHISAEQHDKTVRLTFADSAPGVSDDQ 401
Cdd:COG4191 230 PRLKARGIEVELDLPPDLpPVLGDPGQLEQVLLNLLINAI---DameegEGGRITISTRREGDYVVISVRDNGPGIPPEV 306
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 446597808 402 LQKLFERFYRTegsrNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPL 459
Cdd:COG4191 307 LERIFEPFFTT----KPVGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
211-441 |
3.70e-35 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 135.52 E-value: 3.70e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 211 RVTPTSEDELGKLAQDFNQLaSTLEKnqqMRRDFMADISHELRTPLAVLRGELEAIQDgvrkftPETVASLQAEV-GTLT 289
Cdd:PRK11006 178 RVMPYTEGQLLMVARDVTQM-HQLEG---ARRNFFANVSHELRTPLTVLQGYLEMMQD------QPLEGALREKAlHTMR 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 290 K-------LVDDLHQLSMSDEGALAYQKSSVDLIPLLEVAggafrERFA---SRGL-KLQFSLPDSITVFGDRDRLMQLF 358
Cdd:PRK11006 248 EqtqrmegLVKQLLTLSKIEAAPTIDLNEKVDVPMMLRVL-----EREAqtlSQGKhTITFEVDNSLKVFGNEDQLRSAI 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 359 NNLLENSLRYTDSGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHN 438
Cdd:PRK11006 323 SNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHD 402
|
...
gi 446597808 439 GRI 441
Cdd:PRK11006 403 SRL 405
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
349-460 |
9.26e-34 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 122.76 E-value: 9.26e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 349 GDRDRLMQLFNNLLENSLRYTDSGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGsRNRASGGSGLGLA 428
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|..
gi 446597808 429 ICLNIVEAHNGRIIAAHSPFGGVSITVELPLE 460
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
354-457 |
2.37e-33 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 121.56 E-value: 2.37e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 354 LMQLFNNLLENSLRYTDSGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNraSGGSGLGLAICLNI 433
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSRE--GGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 446597808 434 VEAHNGRIIAAHSPFGGVSITVEL 457
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
192-459 |
4.71e-33 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 130.35 E-value: 4.71e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 192 PVKRLVDGTHKLAAGdftTRVTP--TSEDELGKLAQDFNQLASTLEkNQQMRRDFMADISHELRTPLAVLRGELEAIQDG 269
Cdd:PRK11100 209 SIRRLTRYADAVTEG---KPVPLpkLGSSELRELAQALESMRVKLE-GKAYVEQYVQTLTHELKSPLAAIRGAAELLQED 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 270 -----VRKFtpetVASLQAEVGTLTKLVDDLHQLSMSDEGALAYQKSSVDLIPLLEVAGGAFRERFASRGLKLQFSlPDS 344
Cdd:PRK11100 285 pppedRARF----TGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLR-PDD 359
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 345 ITVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFY---RTEGSRNrasg 421
Cdd:PRK11100 360 ARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYslpRPANGRK---- 435
|
250 260 270
....*....|....*....|....*....|....*...
gi 446597808 422 GSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPL 459
Cdd:PRK11100 436 STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
234-462 |
2.67e-32 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 126.11 E-value: 2.67e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 234 LEKNQQMR--RDFMADISHELRTPLAVLRG-----ELEAIQDGVRKFTpetvASLQAEVGTLTKLVDDLhqLSMSDEGAL 306
Cdd:COG3852 126 LRRAEKLAavGELAAGLAHEIRNPLTGIRGaaqllERELPDDELREYT----QLIIEEADRLNNLVDRL--LSFSRPRPP 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 307 ayQKSSVDLIPLLEVAGGAFRERFAsRGLKLQFSLPDSI-TVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISAE----- 380
Cdd:COG3852 200 --EREPVNLHEVLERVLELLRAEAP-KNIRIVRDYDPSLpEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRverqv 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 381 -----QHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGsrnrasGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITV 455
Cdd:COG3852 277 tlgglRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKE------KGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRI 350
|
....*..
gi 446597808 456 ELPLERD 462
Cdd:COG3852 351 YLPLEQA 357
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
184-465 |
4.23e-32 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 127.03 E-value: 4.23e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 184 PLARGLLapvkRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTLEKNQQMRRDFMADISHELRTPLAVLRGEL 263
Cdd:PRK10604 159 PHWQDML----KLEAAAQRLGDGHLAERIHFDEGSSLERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRL 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 264 EAIQDgvrkFTPETVASLQAEVGTLTKLVDDLHQLSMSDEGALAYQKSSVDLIPLLEVAGGAFRERFASRGLKLqfSLPD 343
Cdd:PRK10604 235 EMSDN----LSAAESQALNRDIGQLEALIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQAVTPEKTVRL--DTPH 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 344 SITVFGDRDRLMQ-LFNNLLENSLRYtdSGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRASGG 422
Cdd:PRK10604 309 QGDYGALDMRLMErVLDNLLNNALRY--AHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGG 386
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 446597808 423 SGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQR 465
Cdd:PRK10604 387 CGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPVWHNLPQ 429
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
159-460 |
2.85e-31 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 125.67 E-value: 2.85e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 159 FDRQQRQTSWLIVALSTLLAALATFPLARGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTLEK-N 237
Cdd:COG4251 200 LLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERsN 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 238 QQMRRdFMADISHELRTPLAVLRGELEAIQ-DGVRKFTPETVASL---QAEVGTLTKLVDDLhqLSMSDEGALAYQKSSV 313
Cdd:COG4251 280 EELEQ-FAYVASHDLREPLRKISGFSQLLEeDYGDKLDEEGREYLeriRDAAERMQALIDDL--LAYSRVGRQELEFEPV 356
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 314 DLIPLLEVAGGAFRERFASRGLklQFSLPDSITVFGDRDRLMQLFNNLLENSLRYTDSG--GSLHISAEQHDKTVRLTFA 391
Cdd:COG4251 357 DLNELLEEVLEDLEPRIEERGA--EIEVGPLPTVRGDPTLLRQVFQNLISNAIKYSRPGepPRIEIGAEREGGEWVFSVR 434
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446597808 392 DSAPGVSDDQLQKLFERFYRTEGSRNRasGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLE 460
Cdd:COG4251 435 DNGIGIDPEYAEKIFEIFQRLHSRDEY--EGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKA 501
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
238-460 |
3.64e-30 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 124.38 E-value: 3.64e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 238 QQMRRDFMADISHELRTPLAVLRGELEAI-QDGVRKFTPET--VASLQAEVGTLTKLVDDLHQLSMSDEGALAYQKssvD 314
Cdd:PRK10490 661 EQLRNALLAALSHDLRTPLTVLFGQAEILtLDLASEGSPHArqASEIRQQVLNTTRLVNNLLDMARIQSGGFNLRK---E 737
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 315 LIPLLEVAGGAFRE-RFASRGLKLQFSLPDSIT-VFGDRDRLMQLFNNLLENSLRYTDSGGSLHISAEQHDKTVRLTFAD 392
Cdd:PRK10490 738 WLTLEEVVGSALQMlEPGLSGHPINLSLPEPLTlIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDVWD 817
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446597808 393 SAPGVSDDQLQKLFERFYRteGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLE 460
Cdd:PRK10490 818 NGPGIPPGQEQLIFDKFAR--GNKESAIPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPLE 883
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
191-458 |
3.62e-29 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 119.49 E-value: 3.62e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 191 APVKRLVDGTHKLAAGDFTTRVTPTSED-ELGKLAQDFNQLASTLEKNQQMRRDFMADISHELRTPLA--VLRGELEAIQ 267
Cdd:PRK09835 211 APIRSVSRQIQNITSKDLDVRLDPQTVPiELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITnlITQTEIALSQ 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 268 DGVRKFTPETVASLQAEVGTLTKLVDDLHQLSMSDEGALAYQKSSVDLI-PLLEVAggAFRERFAS-RGLKLQFSlPDSI 345
Cdd:PRK09835 291 SRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLAdEVGKVF--DFFEAWAEeRGVELRFV-GDPC 367
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 346 TVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRASGGSGL 425
Cdd:PRK09835 368 QVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGI 447
|
250 260 270
....*....|....*....|....*....|...
gi 446597808 426 GLAICLNIVEAHNGRiIAAHSPFGGVSITVELP 458
Cdd:PRK09835 448 GLAIVKSIVVAHKGT-VAVTSDARGTRFVISLP 479
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
217-462 |
1.15e-28 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 116.59 E-value: 1.15e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 217 EDELGKLAQDFNQLASTLEKNQQMrrdfMADISHELRTPL-----AVLRGELEAIQDGVRKfTPETVASLQAEVGTLTKL 291
Cdd:PRK09303 131 SDELFVLRQENETLLEQLKFKDRV----LAMLAHDLRTPLtaaslALETLELGQIDEDTEL-KPALIEQLQDQARRQLEE 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 292 VD----DLHQLSMSDEGALAYQKSSVDLIPLLEVAGGAFRERFASRGLKLQFSLP-DSITVFGDRDRLMQLFNNLLENSL 366
Cdd:PRK09303 206 IErlitDLLEVGRTRWEALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPsDLPSVYADQERIRQVLLNLLDNAI 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 367 RYTDSGGSLHISAeQHDKT--VRLTFADSAPGVSDDQLQKLFERFYRTegSRNRASGGSGLGLAICLNIVEAHNGRIIAA 444
Cdd:PRK09303 286 KYTPEGGTITLSM-LHRTTqkVQVSICDTGPGIPEEEQERIFEDRVRL--PRDEGTEGYGIGLSVCRRIVRVHYGQIWVD 362
|
250
....*....|....*...
gi 446597808 445 HSPFGGVSITVELPLERD 462
Cdd:PRK09303 363 SEPGQGSCFHFTLPVYRG 380
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
239-459 |
3.73e-28 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 114.50 E-value: 3.73e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 239 QMRRDFMADISHELRTPLAVLRGELEAIQDGVR-KFTPETVASLQAEVGTLTKLVDDLhqLSMSDEGALAYQKSSVDLIp 317
Cdd:COG5807 145 SVAGELAAGIAHEIRNPLTSIKGFLQLLQESREdSEREEYFNIIISEIDRINTIITEL--LVLSKPKKFNFKKLNLNDV- 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 318 LLEVAGgAFRERFASRGLKLQFSLPDS-ITVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISAEQHDKTVRLTFADSAPG 396
Cdd:COG5807 222 LEDVIA-LLSTEAILKNISIKYDLADDePVINGDKNQLKQVFINLIKNAIEAMETGGNITIKTYVEGDFVVISVKDEGIG 300
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446597808 397 VSDDQLQKLFERFYRTEGSrnrasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPL 459
Cdd:COG5807 301 IPEEVLEKIGEPFFTTKEE------GTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLPL 357
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-459 |
4.40e-28 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 107.03 E-value: 4.40e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 354 LMQLFNNLLENSLRYTDSggSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRASGGSGLGLAICLNI 433
Cdd:cd16949 1 LARALENVLRNALRYSPS--KILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*.
gi 446597808 434 VEAHNGRIIAAHSPFGGVSITVELPL 459
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
349-461 |
7.26e-28 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 106.68 E-value: 7.26e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 349 GDRDRLMQLFNNLLENSLRYTDSGGSLHISAEQHDkTVRLTFADSAPGVSDDQLQKLFERFYRTEgsrNRASGGSGLGLA 428
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGG-ELTLTVEDNGIGIPPEDLPRIFEPFSTAD---KRGGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|...
gi 446597808 429 ICLNIVEAHNGRIIAAHSPFGGVSITVELPLER 461
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
216-458 |
2.28e-26 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 109.67 E-value: 2.28e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 216 SEDELGKLAQDFNQLASTLEKNQQMRRDFMADISHELRTPLAVLRGELEAIQdgvrKFTPETVASLQAEVGTLTKLVDDL 295
Cdd:PRK10755 112 STLEIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGIRLHLELLE----KQHHIDVAPLIARLDQMMHTVEQL 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 296 HQLSMSdEGALA---YQksSVDLI-----PLLEvaggAFRERFASRGLKLQFSLPDS-ITVFGDRDRLMQLFNNLLENSL 366
Cdd:PRK10755 188 LQLARA-GQSFSsghYQ--TVKLLedvilPSQD----ELSEMLEQRQQTLLLPESAAdITVQGDATLLRLLLRNLVENAH 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 367 RYTDSGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEgSRnraSGGSGLGLAICLNIVEAHNGR-IIAAH 445
Cdd:PRK10755 261 RYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMD-SR---YGGIGLGLSIVSRITQLHHGQfFLQNR 336
|
250
....*....|...
gi 446597808 446 SPFGGVSITVELP 458
Cdd:PRK10755 337 QERSGTRAWVWLP 349
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
190-455 |
6.04e-26 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 109.74 E-value: 6.04e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 190 LAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTLEKNQQMRRDFMADISHELRTPLAVLRGELEAIQ-- 267
Cdd:PRK10337 186 LAPLKKLALALRMRDPDSETPLNATGVPSEVRPLVEALNQLFARTHAMMVRERRFTSDAAHELRSPLAALKVQTEVAQls 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 268 ---DGVRKftpETVASLQAEVGTLTKLVDDLHQLSMSDEGALAYQKSSVDLIPLLEVAGGAFRERFASRGLKLQFSLPDS 344
Cdd:PRK10337 266 dddPQARK---KALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSAVMDIYHTAQQAGIDVRLTLNAH 342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 345 -ITVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISAEQHdktvRLTFADSAPGVSDDQLQKLFERFYRTEGsrnRASGGS 423
Cdd:PRK10337 343 pVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNAR----NFTVRDNGPGVTPEALARIGERFYRPPG---QEATGS 415
|
250 260 270
....*....|....*....|....*....|..
gi 446597808 424 GLGLAICLNIVEAHNGRIIAAHSPFGGVSITV 455
Cdd:PRK10337 416 GLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKV 447
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
244-466 |
1.48e-24 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 106.21 E-value: 1.48e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 244 FMADISHELRTPLAVLRGELEAIQDGV----RKFTpETVASlqaEVGTLTKLVDDLhqLSMSDEGALAYQKSSV-----D 314
Cdd:COG5809 273 LAAGIAHEIRNPLTSLKGFIQLLKDTIdeeqKTYL-DIMLS---ELDRIESIISEF--LVLAKPQAIKYEPKDLntlieE 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 315 LIPLLEVaggafreRFASRGLKLQFSLPDSIT-VFGDRDRLMQLFNNLLENSLRYTDSGGSLHISAEQHDKT-VRLTFAD 392
Cdd:COG5809 347 VIPLLQP-------QALLKNVQIELELEDDIPdILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDDDkVVISVTD 419
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446597808 393 SAPGVSDDQLQKLFERFYRTEgsrnraSGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQRE 466
Cdd:COG5809 420 EGCGIPEERLKKLGEPFYTTK------EKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKLSEQVS 487
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
186-461 |
1.82e-24 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 105.38 E-value: 1.82e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 186 ARGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTLEKNQQMRRDFMADISHELRTPLAVLR----- 260
Cdd:PRK09467 174 IRIQNRPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQMAAGIKQLEDDRTLLMAGVSHDLRTPLTRIRlatem 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 261 --GELEAIQDGVRKFTPE-------------TVASLQAEVGTLTKLVDDLHQLSMSDEGALAyqkssvdlipllevagga 325
Cdd:PRK09467 254 msEEDGYLAESINKDIEEcnaiieqfidylrTGQEMPMEMADLNALLGEVIAAESGYEREIE------------------ 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 326 frerfasrgLKLQfslPDSITVFGDRDRLMQLFNNLLENSLRYtdSGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKL 405
Cdd:PRK09467 316 ---------TALQ---PGPIEVPMNPIAIKRALANLVVNAARY--GNGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHL 381
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 446597808 406 FERFyrTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLER 461
Cdd:PRK09467 382 FQPF--TRGDSARGSSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPLTT 435
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
185-460 |
1.03e-23 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 104.72 E-value: 1.03e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 185 LARGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTLEKN----------------------QQMRR 242
Cdd:PRK15347 317 LRRYLAKPLWRFVDIINKTGPAALEPRLPENRLDELGSIAKAYNQLLDTLNEQydtlenkvaertqalaeakqraEQANK 396
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 243 ---DFMADISHELRTPLAVLRGELEAIQDgvrkfTPETVASLQ-AEVG-----TLTKLVDDLHQLSMSDEGALAYQKSSV 313
Cdd:PRK15347 397 rksEHLTTISHEIRTPLNGVLGALELLQN-----TPLTAEQMDlADTArqctlSLLAIINNLLDFSRIESGQMTLSLEET 471
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 314 DLIPLLEVAGGAFRERFASRGLKLQFSLPDSI--TVFGDRDRLMQLFNNLLENSLRYTDSGG-SLHISAEQHdktvRLTF 390
Cdd:PRK15347 472 ALLPLLDQAMLTIQGPAQSKSLTLRTFVGAHVplYLHLDSLRLRQILVNLLGNAVKFTETGGiRLRVKRHEQ----QLCF 547
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446597808 391 A--DSAPGVSDDQLQKLFERFYRTEGSrnraSGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLE 460
Cdd:PRK15347 548 TveDTGCGIDIQQQQQIFTPFYQADTH----SQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPLN 615
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
246-465 |
1.33e-23 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 102.94 E-value: 1.33e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 246 ADISHELRTPLAVLRGELEAIQDgvrKFTPETVASLQA-----EVGTLTKLVDDLHQLSMSDEgaLAYQksSVDLIPLLE 320
Cdd:PRK10364 242 AGVAHEIRNPLSSIKGLAKYFAE---RAPAGGEAHQLAqvmakEADRLNRVVSELLELVKPTH--LALQ--AVDLNDLIN 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 321 VAGGAFRERFASRGLKLQFSLPDSI-TVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISAEQHDKTVRLTFADSAPGVSD 399
Cdd:PRK10364 315 HSLQLVSQDANSREIQLRFTANDTLpEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAA 394
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446597808 400 DQLQKLFERFYRTEGSrnrasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPL---ERDLQR 465
Cdd:PRK10364 395 DQLEAIFTPYFTTKAE------GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVnitRRDPQG 457
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
235-461 |
2.54e-23 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 103.70 E-value: 2.54e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 235 EKNQQMRRDFMADISHELRTPLAVLRGELEAIQDgvRKFTPETVASLQA--EVG-TLTKLVDDLHQLSMSDEGALAYQKS 311
Cdd:TIGR02956 458 EEANRAKSAFLATMSHEIRTPLNGILGTLELLGD--TGLTSQQQQYLQVinRSGeSLLDILNDILDYSKIEAGHLSISPR 535
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 312 SVDLIPLLEVAGGAFRERFASRGLKLQFSLPDSITVF--GDRDRLMQLFNNLLENSLRYTDSGG-SLHISAeQHDKTVRL 388
Cdd:TIGR02956 536 PFDLNALLDDVHHLMVSRAQLKGIQLRLNIPEQLPNWwqGDGPRIRQVLINLVGNAIKFTDRGSvVLRVSL-NDDSSLLF 614
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446597808 389 TFADSAPGVSDDQLQKLFERFYRTEGsrNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLER 461
Cdd:TIGR02956 615 EVEDTGCGIAEEEQATLFDAFTQADG--RRRSGGTGLGLAISQRLVEAMDGELGVESELGVGSCFWFTLPLTR 685
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
317-457 |
4.45e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 94.62 E-value: 4.45e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 317 PLLEVAGGAFRERFASRGLKLQFSLPDSITVFGDRDRLMQLFNNLLENSLRYTDSggSLHISAEQHDKTVRLTFADSAPG 396
Cdd:cd16954 1 PLLDSLCSALNKVYQRKGVSISLDISPELRFPGERNDLMELLGNLLDNACKWCLE--FVEVTARQTDGGLHLIVDDDGPG 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446597808 397 VSDDQLQKLFERFYRTEGSRNrasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVEL 457
Cdd:cd16954 79 VPESQRSKIFQRGQRLDEQRP----GQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
239-461 |
1.04e-22 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 101.20 E-value: 1.04e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 239 QMRR--------DFMADISHELRTPLAVLRGELEAIQDGV-RKFTPETVASLQAEVGTLTKLVDDLHQLSMSDEGalayQ 309
Cdd:PRK11360 380 RVARqerlaalgELVAGVAHEIRNPLTAIRGYVQIWRQQTsDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRES----Q 455
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 310 KSSVDLIPLLEVAGGAFRERFASRGLKLQFSLPDSI-TVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISAEQH-DKTVR 387
Cdd:PRK11360 456 WQPVSLNALVEEVLQLFQTAGVQARVDFETELDNELpPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYsDGQVA 535
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446597808 388 LTFADSAPGVSDDQLQKLFERFYRTegsrnRASGgSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLER 461
Cdd:PRK11360 536 VSIEDNGCGIDPELLKKIFDPFFTT-----KAKG-TGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINP 603
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
344-457 |
1.20e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 92.47 E-value: 1.20e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 344 SITVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISAEQHDKTVrLTFADSAPGVSDDQLQKLFERFYRTEGsrnRASGGS 423
Cdd:cd16940 4 DIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAV-IRVEDNGPGIDEEELEALFERFYRSDG---QNYGGS 79
|
90 100 110
....*....|....*....|....*....|....
gi 446597808 424 GLGLAICLNIVEAHNGRIIAAHSPFGGVSITVEL 457
Cdd:cd16940 80 GLGLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
190-455 |
2.39e-22 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 99.32 E-value: 2.39e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 190 LAPVKRLVDGTHKLAAGDfTTRVTPTSEDELGKLAQDFNQLAstleKNQQMR----RDFMADISHELRTPLAVLRGELEA 265
Cdd:PRK10815 216 LRPIEALAKQVRELEEGE-REQLDPNPPRELTSLVRNLNRLL----KNERERytkyRTTLTDLTHSLKTPLAVLQSTLRS 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 266 IQDGvRKFTPEtvaslQAE------VGTLTKLVDD-LHQLSM-SDEGALAYQKSSVDliPLLEVAGGAFRERFASRGLKL 337
Cdd:PRK10815 291 LRSG-KQMSVE-----QAEpimleqISRISQQIGYyLHRASMrSEHNLLSRELHSVA--PLLDNLTSALNKVYQRKGVNI 362
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 338 QFSLPDSITVFGDRDRLMQLFNNLLENSLRYTDSggSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRN 417
Cdd:PRK10815 363 TLDISPEITFVGEKNDFMEVMGNVLDNACKYCLE--FVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP 440
|
250 260 270
....*....|....*....|....*....|....*...
gi 446597808 418 rasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITV 455
Cdd:PRK10815 441 ----GQGLGLSVAREITEQYEGKISAGDSPLGGARMEV 474
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
354-459 |
6.07e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 90.24 E-value: 6.07e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 354 LMQLFNNLLENSLRYTDSGG-SLHISAE-QHDKTVRLTF--ADSAPGVSDDQLQKLFERFYRTEGSRNRASGGSGLGLAI 429
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEvTLRVSLEeEEEDGVQLRFsvEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAI 80
|
90 100 110
....*....|....*....|....*....|
gi 446597808 430 CLNIVEAHNGRIIAAHSPFGGVSITVELPL 459
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
204-458 |
6.61e-22 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 99.05 E-value: 6.61e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 204 AAGDFTTRVT-----PTSEDELGKLAQDFNQLASTLEKNQQMRRDFMADISHELRTPLAVLRGELEAIQDGV-RKFTPET 277
Cdd:TIGR03785 443 AAIDSQGRISgaipaSRSRDEIGDLSRSFAQMVARLRQYTHYLENMSSRLSHELRTPVAVVRSSLENLELQAlEQEKQKY 522
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 278 VASLQAEVGTLTKLvddLHqlSMSDEGAL--AYQKSSVDLIPLLEVAGG---AFRERFASRGLKLqfSLPDS-ITVFGDR 351
Cdd:TIGR03785 523 LERAREGTERLSMI---LN--NMSEATRLeqAIQSAEVEDFDLSEVLSGcmqGYQMTYPPQRFEL--NIPETpLVMRGSP 595
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 352 DRLMQLFNNLLENSLRYTDSGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTegsrnRASGGS-----GLG 426
Cdd:TIGR03785 596 ELIAQMLDKLVDNAREFSPEDGLIEVGLSQNKSHALLTVSNEGPPLPEDMGEQLFDSMVSV-----RDQGAQdqphlGLG 670
|
250 260 270
....*....|....*....|....*....|...
gi 446597808 427 LAICLNIVEAHNGRIIAAHSPFG-GVSITVELP 458
Cdd:TIGR03785 671 LYIVRLIADFHQGRIQAENRQQNdGVVFRISLP 703
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
231-460 |
1.38e-21 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 98.27 E-value: 1.38e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 231 ASTLEKNQQM-----RRDFMADISHELRTPLAVLRGELEAIQ-DGVRKFTPETVASLQAEVG-TLTKLVDDLHQLSMSDE 303
Cdd:PRK09959 697 ALEVERNKAInatvaKSQFLATMSHEIRTPISSIMGFLELLSgSGLSKEQRVEAISLAYATGqSLLGLIGEILDVDKIES 776
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 304 GALAYQKSSVDLIPLLEVAGGAFRERFASRGLKLQFS--LPDSITVFGDRDRLMQLFNNLLENSLRYTDSGGS------L 375
Cdd:PRK09959 777 GNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSstFPDHYLVKIDPQAFKQVLSNLLSNALKFTTEGAVkittslG 856
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 376 HIsaEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRAsgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITV 455
Cdd:PRK09959 857 HI--DDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESHPGIGTTFTI 932
|
....*
gi 446597808 456 ELPLE 460
Cdd:PRK09959 933 TIPVE 937
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
246-459 |
2.43e-21 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 96.34 E-value: 2.43e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 246 ADISHELRTPLAVLRGELEAIQDGV---RKFTPETVASL-QAEvGTLTKLvddlhqLSMSDEGALAYQKSSV-----DLI 316
Cdd:COG5805 292 AGIAHEIRNPLTSIKGFLQLLQPGIedkEEYFDIMLSELdRIE-SIISEF------LALAKPQAVNKEKENIneliqDVV 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 317 PLLEVAggafrerfAS-RGLKLQFSLPD-SITVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISAEQHDKTVRLTFADSA 394
Cdd:COG5805 365 TLLETE--------AIlHNIQIRLELLDeDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEG 436
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446597808 395 PGVSDDQLQKLFERFYRTEGSrnrasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPL 459
Cdd:COG5805 437 IGIPEERLKKLGEPFFTTKEK------GTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-458 |
1.35e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 86.29 E-value: 1.35e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 354 LMQLFNNLLENSLRYTDSGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNraSGGSGLGLAICLNI 433
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRN--TEGAGLGLSIAKAI 78
|
90 100
....*....|....*....|....*
gi 446597808 434 VEAHNGRiIAAHSPFGGVSITVELP 458
Cdd:cd16923 79 IELHGGS-ASAEYDDNHDLFKVRLP 102
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
350-458 |
4.86e-20 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 85.24 E-value: 4.86e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 350 DRDRLMQLFNNLLENSLRYTDSGGSLHISAEQHDKT-VRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRASGGSGLGLA 428
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRLNrFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 446597808 429 ICLNIVEAHNGRIIAAHSPFGGVSITVELP 458
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-459 |
2.91e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 82.86 E-value: 2.91e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 360 NLLENSLRYTDSggSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNG 439
Cdd:cd16939 7 NLLRNALRYAHR--TVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVALWHGG 84
|
90 100
....*....|....*....|
gi 446597808 440 RIIAAHSPFGGVSITVELPL 459
Cdd:cd16939 85 HVECDDSELGGACFRLTWPR 104
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
212-462 |
5.95e-18 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 85.29 E-value: 5.95e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 212 VTPTSEDELGKLAQdfnQLASTLEKNQQMRRdfmadISHELRTPLAVLRG--ELEAIQDgVRKFTPETVASLQAEVGTLT 289
Cdd:COG3290 168 ATFRDRTELERLEE---ELEGVKELAEALRA-----QRHDFRNHLHTISGllQLGEYDE-ALEYIDEISEELQELIDSLL 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 290 KLVDDLHqLSmsdegALAYQKSSvdlipllevaggafreRFASRGLKLQFSLPDSITVFGDRDR-LMQLFNNLLENSLRY 368
Cdd:COG3290 239 SRIGNPV-LA-----ALLLGKAA----------------RARERGIDLTIDIDSDLPDLPLSDTdLVTILGNLLDNAIEA 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 369 TDSGGSL----HISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTegsrnRASGGSGLGLAICLNIVEAHNGRIIAA 444
Cdd:COG3290 297 VEKLPEEerrvELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFST-----KLGEGRGLGLALVKQIVEKYGGTIEVE 371
|
250
....*....|....*...
gi 446597808 445 HSPFGGVSITVELPLERD 462
Cdd:COG3290 372 SEEGEGTVFTVRLPKEGE 389
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-458 |
1.02e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 78.26 E-value: 1.02e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 354 LMQLFNNLLENSLRYtdSGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNraSGGSGLGLAICLNI 433
Cdd:cd16950 1 LKRVLSNLVDNALRY--GGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRI 76
|
90 100
....*....|....*....|....*
gi 446597808 434 VEAHNGRIIAAHSPFGGVSITVELP 458
Cdd:cd16950 77 SDAHGGSLTLANRAGGGLCARIELP 101
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
219-461 |
5.04e-17 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 84.19 E-value: 5.04e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 219 ELGKLAQDFNQLASTLEKNQQMRRDFMADISHELRTPLAVLRGELEAIQDgvRKFTPETVASLQA--EVG-TLTKLVDDL 295
Cdd:PRK11466 422 ELQELVIEHRQARAEAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLAD--NPALNAQRDDLRAitDSGeSLLTILNDI 499
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 296 HQLSMSDEGA--LAYQKSSVDLIPLLEVAGGAFRERFASRGLKLQFSLPDSI--TVFGDRDRLMQLFNNLLENSLRYTDS 371
Cdd:PRK11466 500 LDYSAIEAGGknVSVSDEPFEPRPLLESTLQLMSGRVKGRPIRLATDIADDLptALMGDPRRIRQVITNLLSNALRFTDE 579
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 372 GgSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRnrasGGSGLGLAICLNIVEAHNGRIIAAHSPFGGV 451
Cdd:PRK11466 580 G-SIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGS 654
|
250
....*....|
gi 446597808 452 SITVELPLER 461
Cdd:PRK11466 655 CFCLRLPLRV 664
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-457 |
8.77e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 76.40 E-value: 8.77e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 341 LPDS-ITVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRA 419
Cdd:cd16947 7 IPDRpIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSA 86
|
90 100 110
....*....|....*....|....*....|....*...
gi 446597808 420 SGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVEL 457
Cdd:cd16947 87 KQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-458 |
8.92e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 75.70 E-value: 8.92e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 354 LMQLFNNLLENSLRYTDSGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRASGGSGLGLAICLNI 433
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*
gi 446597808 434 VEAHNGRIIAAHSPFGGVSITVELP 458
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFP 105
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-458 |
3.85e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 73.97 E-value: 3.85e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 354 LMQLFNNLLENSLR----YTDSGGSLHISAEQHDK-TVRLTFADSAPGVSDDQLQKLFERFYRTEGSrnrasgGSGLGLA 428
Cdd:cd16920 1 IQQVLINLVRNGIEamseGGCERRELTIRTSPADDrAVTISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLS 74
|
90 100 110
....*....|....*....|....*....|
gi 446597808 429 ICLNIVEAHNGRIIAAHSPFGGVSITVELP 458
Cdd:cd16920 75 ICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-456 |
1.11e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 72.88 E-value: 1.11e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 350 DRDRLMQLFNNLLENSLRYTDSGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNraSGG-SGLGLA 428
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRR--SGGhYGMGLY 78
|
90 100
....*....|....*....|....*...
gi 446597808 429 ICLNIVEAHNGRIIAAHSPFGGVSITVE 456
Cdd:cd16975 79 IAKNLVEKHGGSLIIENSQKGGAEVTVK 106
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-458 |
1.63e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 71.97 E-value: 1.63e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 354 LMQLFNNLLENSLRYTDSG--GSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGsrNRASGGSGLGLAICL 431
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrpPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 446597808 432 NIVEAHNGRIIAAHSPFGGVSITVELP 458
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-453 |
1.30e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 69.80 E-value: 1.30e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 354 LMQLFNNLLENSLRYTDSGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYrtegSRNRASGG---SGLGLAIC 430
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFY----SLPRPHSGqksTGLGLAFV 80
|
90 100
....*....|....*....|...
gi 446597808 431 LNIVEAHNGRIIAAHSPFGGVSI 453
Cdd:cd16945 81 QEVAQLHGGRITLRNRPDGVLAF 103
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
234-459 |
4.26e-14 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 74.59 E-value: 4.26e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 234 LEKNQQMRRDFMADISHELRTPL--------AVLRGELEAIQdgvRKFtpetVASLQAEVGTLTKLVDDLHQLSMSDEGA 305
Cdd:PRK11091 276 LEKASRDKTTFISTISHELRTPLngivglsrILLDTELTAEQ---RKY----LKTIHVSAITLGNIFNDIIDMDKMERRK 348
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 306 LAYQKSSVDLIPL---LEVAGGAFRERfasRGLKLQF----SLPDSITVfgDRDRLMQLFNNLLENSLRYTDSGG-SLHI 377
Cdd:PRK11091 349 LQLDNQPIDFTDFladLENLSGLQAEQ---KGLRFDLepllPLPHKVIT--DGTRLRQILWNLISNAVKFTQQGGvTVRV 423
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 378 SAEQHDktvRLTF--ADSAPGVSDDQLQKLFERFYRTEGSR-NRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSIT 454
Cdd:PRK11091 424 RYEEGD---MLTFevEDSGIGIPEDELDKIFAMYYQVKDSHgGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFT 500
|
....*
gi 446597808 455 VELPL 459
Cdd:PRK11091 501 LTIHA 505
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-458 |
5.55e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 67.98 E-value: 5.55e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 354 LMQLFNNLLENSLRYT-DSGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYrTEGSRNRASG-GSGLGLAICL 431
Cdd:cd16953 1 LGQVLRNLIGNAISFSpPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSISR 79
|
90 100 110
....*....|....*....|....*....|.
gi 446597808 432 NIVEAHNGRIIAA-HSP---FGGVSITVELP 458
Cdd:cd16953 80 QIIEAHGGISVAEnHNQpgqVIGARFTVQLP 110
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
187-458 |
1.02e-13 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 73.18 E-value: 1.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 187 RGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAqdfNQLASTLEKNQQMRRDFMADISHELRTPLAVLRGELEAI 266
Cdd:COG4192 349 RRLVKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIA---RLLRVFRDQAIEKTQELETEIEERKRIEKNLRQTQDELI 425
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 267 QdgvrkftpetvASLQAEVG-TLTKLVDDLHQ----LSM------------SDEGALAY--------------------- 308
Cdd:COG4192 426 Q-----------AAKMAVVGqTMTSLAHELNQplnaMSMylfsakkaleqeNYAQLPTSldkiegliermdkiikslrqf 494
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 309 -QKSSVDL--IPLLEVAGGAFrERFASRGLKLQFSL--PDSITVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISAEQHD 383
Cdd:COG4192 495 sRKSDTPLqpVDLRQVIEQAW-ELVESRAKPQQITLhiPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNA 573
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446597808 384 KTVRLTFADSAPGVSDdqLQKLFERFYRTEgsrnraSGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELP 458
Cdd:COG4192 574 ENLRVAISDNGNGWPL--VDKLFTPFTTTK------EVGLGLGLSICRSIMQQFGGDLYLASTLERGAMVILEFN 640
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
351-459 |
2.29e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 65.91 E-value: 2.29e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 351 RDRLMQLFNNLLENSLRYTDSGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNrasgGSGLGLAIC 430
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLS 76
|
90 100
....*....|....*....|....*....
gi 446597808 431 LNIVEAHNGRIIAAHSPFGGVSITVELPL 459
Cdd:cd16943 77 YRIIQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
190-234 |
2.64e-13 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 64.00 E-value: 2.64e-13
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 446597808 190 LAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTL 234
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
207-459 |
6.28e-13 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 71.16 E-value: 6.28e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 207 DFTTRVtptsedelgKLAQDFNQLASTLEKNQQMRRDFMADISHELRTPLAVLRGELEAIQDgvrKFTPETVASL----Q 282
Cdd:PRK10841 422 DVSARV---------KMEESLQEMAQAAEQASQSKSMFLATVSHELRTPLYGIIGNLDLLQT---KELPKGVDRLvtamN 489
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 283 AEVGTLTKLVDDLHQLSMSDEGALAYQKSsvdlipllevaggafreRFASRGL-------------KLQFSL-----PD- 343
Cdd:PRK10841 490 NSSSLLLKIISDILDFSKIESEQLKIEPR-----------------EFSPREVinhitanylplvvKKRLGLycfiePDv 552
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 344 SITVFGDRDRLMQLFNNLLENSLRYTDSGG-SLHISAeQHDktvRLTFA--DSAPGVSDDQLQKLFERFYRTEGSRNRAS 420
Cdd:PRK10841 553 PVALNGDPMRLQQVISNLLSNAIKFTDTGCiVLHVRV-DGD---YLSFRvrDTGVGIPAKEVVRLFDPFFQVGTGVQRNF 628
|
250 260 270
....*....|....*....|....*....|....*....
gi 446597808 421 GGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPL 459
Cdd:PRK10841 629 QGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIPL 667
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
240-304 |
7.29e-13 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 63.38 E-value: 7.29e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446597808 240 MRRDFMADISHELRTPLAVLRGELEAIQDGVRK-FTPETVASLQAEVGTLTKLVDDLHQLSMSDEG 304
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDeEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-457 |
1.55e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 63.63 E-value: 1.55e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 354 LMQLFNNLLENSLrytDSGGS-----LHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTegsrnRASG-GSGLGL 427
Cdd:cd16976 1 IQQVLMNLLQNAL---DAMGKvenprIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTT-----KPVGkGTGLGL 72
|
90 100 110
....*....|....*....|....*....|
gi 446597808 428 AICLNIVEAHNGRIIAAHSPFGGVSITVEL 457
Cdd:cd16976 73 SISYGIVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
238-299 |
4.72e-12 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 61.07 E-value: 4.72e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446597808 238 QQMRRDFMADISHELRTPLAVLRGELEAIQDGVRKFTP--ETVASLQAEVGTLTKLVDDLHQLS 299
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEqrEYLERIREEAERLLRLINDLLDLS 64
|
|
| HAMP |
pfam00672 |
HAMP domain; |
185-236 |
6.48e-12 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 60.33 E-value: 6.48e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 446597808 185 LARGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTLEK 236
Cdd:pfam00672 2 LARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
240-304 |
8.82e-12 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 60.27 E-value: 8.82e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446597808 240 MRRDFMADISHELRTPLAVLRGELEAIQDGvrKFTPET---VASLQAEVGTLTKLVDDLHQLSMSDEG 304
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDT--ELSEEQreyLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
243-441 |
2.90e-11 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 66.03 E-value: 2.90e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 243 DFMADISHELRTPLavlrgeleaiqDGVRKFTPETV-----ASLQAEVGT-------LTKLVDDLHQLSMSDEGALAYQK 310
Cdd:PRK11107 295 EFLANMSHELRTPL-----------NGVIGFTRQTLktpltPTQRDYLQTiersannLLAIINDILDFSKLEAGKLVLEN 363
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 311 ------SSVD-LIPLLevAGGAfRERfasrGLKL----QFSLPDSitVFGDRDRLMQLFNNLLENSLRYTDSGgSLHISA 379
Cdd:PRK11107 364 ipfslrETLDeVVTLL--AHSA-HEK----GLELtlniDPDVPDN--VIGDPLRLQQIITNLVGNAIKFTESG-NIDILV 433
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446597808 380 E---QHDKTVRLTF--ADSAPGVSDDQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRI 441
Cdd:PRK11107 434 ElraLSNTKVQLEVqiRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDI 500
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
142-462 |
3.83e-11 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 64.65 E-value: 3.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 142 AVIASPVERLTRNTdinfdRQQRQTSWLIVALSTLLAALATFPLARGLLAPVKRLVDGTHKLAAGDFTtRVTPTSEDELG 221
Cdd:COG2972 139 LVSLIPKSELFRGL-----FSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLV-RLEVSGNDEIG 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 222 KLAQDFNQLastLEKNQQMrrdfmadISHELRTPLAVLRGELEAIQdgVRKF------TPETVASL-----QAEVGTLTK 290
Cdd:COG2972 213 ILARSFNEM---VERIKEL-------IEEVYELELEKKEAELKALQ--AQINphflfnTLNSIRWLaeledPEEAEEMLE 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 291 LVDDLHQLSMSDEGalayqkssvDLIPL---LEVAGG---AFRERFASRgLKLQFSLPDSItvfgdRD-----RLMQlfn 359
Cdd:COG2972 281 ALSKLLRYSLSKGD---------ELVTLeeeLELIKSyleIQKLRFGDR-LEVEIEIDEEL-----LDllipkLILQ--- 342
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 360 NLLENSLRY----TDSGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFyrtegsrNRASGGSGLGLAICLNIVE 435
Cdd:COG2972 343 PLVENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLK 415
|
330 340 350
....*....|....*....|....*....|
gi 446597808 436 AHNG---RIIAAHSPFGGVSITVELPLERD 462
Cdd:COG2972 416 LYYGeeyGLEIESEPGEGTTVTIRIPLEEE 445
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
187-235 |
3.97e-11 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 58.03 E-value: 3.97e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 446597808 187 RGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTLE 235
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLE 49
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
207-459 |
4.20e-11 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 65.47 E-value: 4.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 207 DFTTRVTPTSEDELGKLAQDFNQLASTLEKN-------------QQMRR-----DFMADISHELRTPLAVLRGELEAIQD 268
Cdd:PRK13837 398 GRQRYGLRPPAGELQLLELALDCLAHAIERRrleterdalerrlEHARRleavgTLASGIAHNFNNILGAILGYAEMALN 477
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 269 GVRKFTP--ETVASLQAEVGTLTKLVDDLhqLSMSDEGALAYQKSSV-----DLIPLLEVAGGafrerfasRGLKLQFSL 341
Cdd:PRK13837 478 KLARHSRaaRYIDEIISAGARARLIIDQI--LAFGRKGERNTKPFDLselvtEIAPLLRVSLP--------PGVELDFDQ 547
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 342 PDSI-TVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISAEQHDKT---------------VRLTFADSAPGVSDDQLQKL 405
Cdd:PRK13837 548 DQEPaVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAKLRapkvlshgvlppgryVLLRVSDTGAGIDEAVLPHI 627
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 446597808 406 FERFYRTEgsrnraSGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPL 459
Cdd:PRK13837 628 FEPFFTTR------AGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPP 675
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-458 |
3.69e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 56.91 E-value: 3.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 345 ITVFGDrdrlmqLFNNLLENSLRYTDSGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRasggsG 424
Cdd:cd16915 2 ITIVGN------LIDNALDALAATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGER-----G 70
|
90 100 110
....*....|....*....|....*....|....
gi 446597808 425 LGLAICLNIVEAHNGRIIAAHSPFGGVSITVELP 458
Cdd:cd16915 71 IGLALVRQSVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
185-467 |
3.77e-10 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 62.05 E-value: 3.77e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 185 LARGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTLEKNQQMR--------RDFMADISHELRTPL 256
Cdd:COG2770 232 LARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAeeeeelaeAELARLLEALLELLL 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 257 AVLRGELEAIQDGVRKFTPETVASLQAEVGTLTKLVDDLHQLSMSDEGALAYQKSSVDLIPLLEVAGGAFRERFASRGLK 336
Cdd:COG2770 312 ALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAV 391
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 337 LQFSLPDSITVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSR 416
Cdd:COG2770 392 LALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEA 471
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 446597808 417 NRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQREV 467
Cdd:COG2770 472 LLLLAALLLLAALGALELLLLEEEEEAGAAAEELAEELLLLEGLLLLLLLE 522
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
51-466 |
1.36e-09 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 59.90 E-value: 1.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 51 LQLLSDALGEQYAQHGNWRFLRNNDRFVFQILRSFEHDNSEDKPGPGMPPHGWRTQFWVVDQNNKVLVGPRAPIPPDGTR 130
Cdd:COG3850 4 LLLLALALLRLLLALLALLLLALLLLSLLALLLLLERTLLRLLSLLASAGLLAALLAALLLLLSLGLLALLLALLLLLLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 131 RPILVNGAEVGAVIASPVERLTRNTDINFDRQQRQTSWLIVALSTLLAALATFPLARGLLAPVKRLVDGTHKLAAGDFTT 210
Cdd:COG3850 84 LLLAALLSLLLLLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 211 RVTPTSEDELGKLAQDFNQLASTLEK--------NQQMRRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPETVASLQ 282
Cdd:COG3850 164 RVPVSGRDELGTLARAFNRMADELQElyaeleeeEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 283 AEVGTLTKLVDDLHQLSMSDEGALAYQKSSVDLIPLLEVAGGAFRERFASRGLKLQFSLPDSITVFGDRDRLMQLFNNLL 362
Cdd:COG3850 244 LQDALAESELLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAI 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 363 ENSLRYTDSGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRII 442
Cdd:COG3850 324 ANASLLLIALASVVAALLELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGL 403
|
410 420
....*....|....*....|....
gi 446597808 443 AAHSPFGGVSITVELPLERDLQRE 466
Cdd:COG3850 404 VDVEGGVAGEGGLVVLIVSIIAGG 427
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
133-234 |
9.01e-09 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 57.72 E-value: 9.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 133 ILVNGAEVGAVIASPVERLTRNTDINFDRQQRQTSWLIVALSTLLAALATFPLARGLLAPVKRLVDGTHKLAAGDFTTRV 212
Cdd:COG0840 150 LALLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRI 229
|
90 100
....*....|....*....|..
gi 446597808 213 TPTSEDELGKLAQDFNQLASTL 234
Cdd:COG0840 230 DVDSKDEIGQLADAFNRMIENL 251
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-458 |
1.21e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 49.71 E-value: 1.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 354 LMQLFNNLLENSLRYTDSGG-----------SLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEgsrnraSGG 422
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSGgeiilrtrtqrQVTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPMVSGR------ENG 74
|
90 100 110
....*....|....*....|....*....|....*.
gi 446597808 423 SGLGLAICLNIVEAHNGRIIAAHSPfGGVSITVELP 458
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQP-GHTVFSVSLP 109
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
229-430 |
1.27e-07 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 54.17 E-value: 1.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 229 QLAS-TLEKNQQMRRDFMADISHELRTPLAVLRGELEAI-QDGVRKFTPETVASLQAEVGTLTKLVDDLHQLSMSDEGAL 306
Cdd:PRK10618 437 QQAQrEYEKNQQARKAFLQNIGDELKQPLQSLAQLAAQLrQTSDEEQQQPELDQLAEQSDVLVRLVDNIQLLNMLETQDW 516
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 307 AYQKSSVDLIPLLEvagGAFRERFAS---RGLKL--QFSLPDSITVFGDRDRLMQLFNNLLENSLRYTDSGG-SLHI-SA 379
Cdd:PRK10618 517 KPEQELFSLQDLID---EVLPEVLPAikrKGLQLliHNHLKAEQLRIGDRDALRKILLLLLNYAITTTAYGKiTLEVdQD 593
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 446597808 380 EQHDKTVRLTFADSAPGVSDDQLQKLfeRF-YRTEGSRNRASGGSGLGLAIC 430
Cdd:PRK10618 594 ESSPDRLTIRILDTGAGVSIKELDNL--HFpFLNQTQGDRYGKASGLTFFLC 643
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-458 |
6.61e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 47.92 E-value: 6.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 350 DRDRLMQLFNNLLENSL-----RYTDSG-GSLHISAEQHDKTVrLTFADSAPGVSDDQLQKLFERFYRTEgsrnraSGGS 423
Cdd:cd16944 1 DTTQISQVLTNILKNAAeaiegRPSDVGeVRIRVEADQDGRIV-LIVCDNGKGFPREMRHRATEPYVTTR------PKGT 73
|
90 100 110
....*....|....*....|....*....|....*
gi 446597808 424 GLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELP 458
Cdd:cd16944 74 GLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
333-462 |
1.70e-06 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 50.30 E-value: 1.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 333 RGLKLQFS----LPDS---------ITVFGdrdrlmqlfnNLLENSLRYTDS--GGSLHISAEQHDKTVRLTFADSAPGV 397
Cdd:PRK11086 410 LGITLIISedsqLPDSgdedqvhelITILG----------NLIENALEAVGGeeGGEISVSLHYRNGWLHCEVSDDGPGI 479
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446597808 398 SDDQLQKLFERFYRTEGSrNRasggsGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERD 462
Cdd:PRK11086 480 APDEIDAIFDKGYSTKGS-NR-----GVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGE 538
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-428 |
3.14e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 45.74 E-value: 3.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 350 DRDRLMQLFNNLLENSLRYTDSGGSLHISAEQHDKTVRLTFADSAPGVSDDQLQKLFERFYRTEGSRN-RASGGSGLGLA 428
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNfQESTGMGLYLV 81
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
218-459 |
1.11e-05 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 47.38 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 218 DELGKLAQDFNQLAstlekNQQMRRDFMADISHELRTPLAVLRGE---LE-AIQD-GVRKFTPETVAslQAEvgTLTKLV 292
Cdd:PRK11073 112 DNQRRLSQEQLQHA-----QQVAARDLVRGLAHEIKNPLGGLRGAaqlLSkALPDpALTEYTKVIIE--QAD--RLRNLV 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 293 DDL---HQLSMSDEGALAYQKSSVDLIPLLEVAGGAFRERfasrglKLQFSLPDsITVfgDRDRLMQLFNNLLENSLR-Y 368
Cdd:PRK11073 183 DRLlgpQRPGTHVTESIHKVAERVVQLVSLELPDNVRLIR------DYDPSLPE-LAH--DPDQIEQVLLNIVRNALQaL 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 369 TDSGGS----------LHISAEQHDKTVRLTFADSAPGVSDdQLQKLFerFYRTEGSRnraSGGSGLGLAICLNIVEAHN 438
Cdd:PRK11073 254 GPEGGTitlrtrtafqLTLHGERYRLAARIDIEDNGPGIPP-HLQDTL--FYPMVSGR---EGGTGLGLSIARNLIDQHS 327
|
250 260
....*....|....*....|.
gi 446597808 439 GRIIAAHSPfGGVSITVELPL 459
Cdd:PRK11073 328 GKIEFTSWP-GHTEFSVYLPI 347
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
305-461 |
6.04e-05 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 45.28 E-value: 6.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 305 ALAYQK-------SSVDLIPLLEVAGGAFRERFASRGLKLQFSLPDsitVFGDRDRLMQL---FNNLLENSLRY---TDS 371
Cdd:COG3920 344 ALVHELlyqsedwEGVDLRDYLRELLEPLRDSYGGRGIRIELDGPD---VELPADAAVPLgliLNELVTNALKHaflSGE 420
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 372 GGSLHISAEQHDKTVRLTFADSAPGVSDDqlqklferfyrtegsrNRASGGSGLGLAICLNIVEAHNGRIIAAHSPfgGV 451
Cdd:COG3920 421 GGRIRVSWRREDGRLRLTVSDNGVGLPED----------------VDPPARKGLGLRLIRALVRQLGGTLELDRPE--GT 482
|
170
....*....|
gi 446597808 452 SITVELPLER 461
Cdd:COG3920 483 RVRITFPLAE 492
|
|
| HATPase_Phy-like |
cd16932 |
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana ... |
348-441 |
7.35e-05 |
|
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana Phytochrome A, B, C, D and E; This family includes the histidine kinase-like ATPase (HATPase) domains of plant red/far-red photoreceptors, the phytochromes, and includes the Arabidopsis thaliana phytochrome family phyA-phyE. Following red light absorption, biologically inactive forms of phytochromes convert to active forms, which rapidly convert back to inactive forms upon far-red light irradiation. Phytochromes can be considered as having an N-terminal photosensory region to which a bilin chromophore is bound, and a C-terminal output region, which includes the HATPase domain represented here, and is involved in dimerization and presumably contributes to relaying the light signal to downstream signaling events.
Pssm-ID: 340409 [Multi-domain] Cd Length: 113 Bit Score: 41.87 E-value: 7.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 348 FGDRDRLMQLFNNLLENSLRYTDS-GGSLHISAEQHDKT-------VRLTF--ADSAPGVSDDQLQKLFERfyRTEGSRN 417
Cdd:cd16932 1 YGDQIRLQQVLADFLLNAVRFTPSpGGWVEIKVSPTKKQigdgvhvIHLEFriTHPGQGLPEELVQEMFEE--NQWTTQE 78
|
90 100
....*....|....*....|....
gi 446597808 418 rasggsGLGLAICLNIVEAHNGRI 441
Cdd:cd16932 79 ------GLGLSISRKLVKLMNGDV 96
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
256-462 |
6.12e-04 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 41.53 E-value: 6.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 256 LAVLRGELEAIQDGVRKFTPETVASLQAEVGTLTKLVDDLHQLSMS-DEGALAyqksSVDLIPLLEvagGAFRERFASRG 334
Cdd:COG4585 69 LSAIKLQLEAARRLLDADPEAAREELEEIRELAREALAELRRLVRGlRPPALD----DLGLAAALE---ELAERLLRAAG 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 335 LKLQFSLPDSITVFGDRDRLmQLFNNLLE---NSLRYtdSGGS-LHISAEQHDKTVRLTFADSAPGVSDDQLqklferfy 410
Cdd:COG4585 142 IRVELDVDGDPDRLPPEVEL-ALYRIVQEaltNALKH--AGATrVTVTLEVDDGELTLTVRDDGVGFDPEAA-------- 210
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 446597808 411 rtegsrnrasGGSGLGLAiclNI---VEAHNGRIIAAHSPFGGVSITVELPLERD 462
Cdd:COG4585 211 ----------PGGGLGLR---GMrerAEALGGTLTIGSAPGGGTRVRATLPLAAA 252
|
|
| HATPase_AgrC-ComD-like |
cd16935 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
334-441 |
7.84e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 39.48 E-value: 7.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446597808 334 GLKLQFSLPDSITVFGDRDRLMQLFNNLLEN----SLRYTDSGGSLHISAEQHDKTVRLTFADSAPGvsddQLQKLFERF 409
Cdd:cd16935 17 GIEFTIEIDIPILLPISPLDLCIIFGNLLDNaieaCAKIDKENRFIHLKIRQKKGFLIISIENSYEG----ELKKKNGLF 92
|
90 100 110
....*....|....*....|....*....|..
gi 446597808 410 YRTEGSRNRasggsGLGLAICLNIVEAHNGRI 441
Cdd:cd16935 93 LSTKKDKNH-----GIGLKSIREIVKKYNGNL 119
|
|
| PRK10600 |
PRK10600 |
nitrate/nitrite two-component system sensor histidine kinase NarX; |
183-234 |
5.36e-03 |
|
nitrate/nitrite two-component system sensor histidine kinase NarX;
Pssm-ID: 182581 [Multi-domain] Cd Length: 569 Bit Score: 39.27 E-value: 5.36e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 446597808 183 FPLARGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTL 234
Cdd:PRK10600 143 IWLRRRLLQPWRQLLSMANAVSHRDFTQRANISGRDEMAMLGTALNNMSAEL 194
|
|
| PRK15041 |
PRK15041 |
methyl-accepting chemotaxis protein; |
183-234 |
8.73e-03 |
|
methyl-accepting chemotaxis protein;
Pssm-ID: 185001 [Multi-domain] Cd Length: 554 Bit Score: 38.40 E-value: 8.73e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 446597808 183 FPLARGLLAPVKRLVDGTHKLAAGDFTTRVTPTSEDELGKLAQDFNQLASTL 234
Cdd:PRK15041 212 FGIKASLVAPMNRLIDSIRHIAGGDLVKPIEVDGSNEMGQLAESLRHMQGEL 263
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