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Conserved domains on  [gi|446593607|ref|WP_000670953|]
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MULTISPECIES: staphylobilin-forming heme oxygenase IsdG [Staphylococcus]

Protein Classification

antibiotic biosynthesis monooxygenase family protein; VOC family protein( domain architecture ID 10014188)

antibiotic biosynthesis monooxygenase family protein may be involved in the biosynthesis of several antibiotics; similar to Streptomyces ambofaciens anthrone oxidase-like protein| vicinal oxygen chelate (VOC) family protein uses a metal center to coordinate a substrate, intermediate, or transition state through vicinal oxygen atoms

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13312 PRK13312
staphylobilin-forming heme oxygenase IsdG;
1-107 9.67e-69

staphylobilin-forming heme oxygenase IsdG;


:

Pssm-ID: 139480  Cd Length: 107  Bit Score: 201.11  E-value: 9.67e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446593607   1 MKFMAENRLTLTKGTAKDIIERLYTRHGIETLEGFDGMFVTQTLEQEDFDEVKILTVWKSKQAFTDWLKSDVFKAAHKHV 80
Cdd:PRK13312   1 MKFMAENRLTLTKGTAKDIIERFYTRHGIETLEGFDGMFVTQTLEQEDFDEVKILTVWKSKQAFTDWLKSDVFKAAHKHV 80

                         90       100
                 ....*....|....*....|....*..
gi 446593607  81 RSKNEDESSPIINNKVITYDIGYSYMK 107
Cdd:PRK13312  81 RSKNEDESSPIINNKVITYDIGYSYMK 107
 
Name Accession Description Interval E-value
PRK13312 PRK13312
staphylobilin-forming heme oxygenase IsdG;
1-107 9.67e-69

staphylobilin-forming heme oxygenase IsdG;


Pssm-ID: 139480  Cd Length: 107  Bit Score: 201.11  E-value: 9.67e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446593607   1 MKFMAENRLTLTKGTAKDIIERLYTRHGIETLEGFDGMFVTQTLEQEDFDEVKILTVWKSKQAFTDWLKSDVFKAAHKHV 80
Cdd:PRK13312   1 MKFMAENRLTLTKGTAKDIIERFYTRHGIETLEGFDGMFVTQTLEQEDFDEVKILTVWKSKQAFTDWLKSDVFKAAHKHV 80

                         90       100
                 ....*....|....*....|....*..
gi 446593607  81 RSKNEDESSPIINNKVITYDIGYSYMK 107
Cdd:PRK13312  81 RSKNEDESSPIINNKVITYDIGYSYMK 107
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 3-77 8.73e-13

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 58.44  E-value: 8.73e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446593607    3 FMAENRLTLTKGTAKDIIERLYTRHGI-ETLEGFDGMFVTQtlEQEDFDEVKILTVWKSKQAFTDWLKSDVFKAAH 77
Cdd:pfam03992   1 IVVVAEIRVKPGKAEEFEEALAELVEAtRNEPGCLSYELLR--SLEDPDEYVVLEVWEDEAAFEAHLQSPHFKAAH 74
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 7-89 6.23e-12

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


Pssm-ID: 441901  Cd Length: 98  Bit Score: 56.93  E-value: 6.23e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446593607   7 NRLTLTKGTAKDIIERLYTRHG-IETLEGFDGMFVTQTLEQEDfdEVKILTVWKSKQAFTDWLKSDVFKAAHKHVRSKNE 85
Cdd:COG2329    6 NRFRVKPGQEEEFEEAFAERRElLAEQPGFLGFELLRSLEDPG--EYLVVSYWESEEAFRAWFRSSEHRAAHAKGREILA 83


                 ....
gi 446593607  86 DESS 89
Cdd:COG2329   84 GPPR 87
 
Name Accession Description Interval E-value
PRK13312 PRK13312
staphylobilin-forming heme oxygenase IsdG;
1-107 9.67e-69

staphylobilin-forming heme oxygenase IsdG;


Pssm-ID: 139480  Cd Length: 107  Bit Score: 201.11  E-value: 9.67e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446593607   1 MKFMAENRLTLTKGTAKDIIERLYTRHGIETLEGFDGMFVTQTLEQEDFDEVKILTVWKSKQAFTDWLKSDVFKAAHKHV 80
Cdd:PRK13312   1 MKFMAENRLTLTKGTAKDIIERFYTRHGIETLEGFDGMFVTQTLEQEDFDEVKILTVWKSKQAFTDWLKSDVFKAAHKHV 80

                         90       100
                 ....*....|....*....|....*..
gi 446593607  81 RSKNEDESSPIINNKVITYDIGYSYMK 107
Cdd:PRK13312  81 RSKNEDESSPIINNKVITYDIGYSYMK 107
PRK13313 PRK13313
staphylobilin-forming heme oxygenase IsdI;
3-107 1.18e-50

staphylobilin-forming heme oxygenase IsdI;


Pssm-ID: 183968  Cd Length: 108  Bit Score: 155.48  E-value: 1.18e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446593607   3 FMAENRLTLTKGTAKDIIERLYTRHGIETLEGFDGMFVTQTLEQEDFDEVKILTVWKSKQAFTDWLKSDVFKAAHKHVRS 82
Cdd:PRK13313   2 FMAENRLQLQKGSAEETIERFYNRQGIETIEGFQQMFVTKTLNTEDTDEVKILTIWESEDSFNNWLNSDVFKEAHKNVRL 81

                         90       100
                 ....*....|....*....|....*..
gi 446593607  83 KNEDE--SSPIINNKVITYDIGYSYMK 107
Cdd:PRK13313  82 KSDDDgqQSPILSNKVFKYDIGYHYQK 108
PRK13315 PRK13315
heme oxygenase;
3-101 2.84e-20

heme oxygenase;


Pssm-ID: 237345  Cd Length: 107  Bit Score: 78.30  E-value: 2.84e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446593607   3 FMAENRLTLTKGTAKDIIERLYTRHGIETLEGFDGMFVTQTLEQEDFDEVKILTVWKSKQAFTDWLKSDVFKAAHKHvRS 82
Cdd:PRK13315   2 IVVTNRITVKKGFAAKMAPRFTKGGPLEELEGFHKVEVWLIDNDDEYDEMYVNMWWETEEDFEAWRNSDAFKEAHKR-PS 80

                         90
                 ....*....|....*....
gi 446593607  83 KNEDESSPIINNKVITYDI 101
Cdd:PRK13315  81 KTESDDSPIIGSEIVKSEV 99
PRK13314 PRK13314
heme oxygenase;
7-101 4.61e-14

heme oxygenase;


Pssm-ID: 183969  Cd Length: 107  Bit Score: 62.59  E-value: 4.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446593607   7 NRLTLTKGTAKDIIERLYTRHGIETLEGFDGMFVTQTLEQEDFDEVKILTVWKSKQAFTDWLKSDVFKAAHKHVRSKNEd 86
Cdd:PRK13314   6 NTAKITKGNGHKLIDRFNKVGKVETMPGFLGLEVLLTQNTVDYDEVTISTRWNAKEDFQGWTKSPAFKAAHSHQGGMPD- 84

                         90
                 ....*....|....*
gi 446593607  87 essPIINNKVITYDI 101
Cdd:PRK13314  85 ---YILDNKISYYDV 96
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 3-77 8.73e-13

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 58.44  E-value: 8.73e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446593607    3 FMAENRLTLTKGTAKDIIERLYTRHGI-ETLEGFDGMFVTQtlEQEDFDEVKILTVWKSKQAFTDWLKSDVFKAAH 77
Cdd:pfam03992   1 IVVVAEIRVKPGKAEEFEEALAELVEAtRNEPGCLSYELLR--SLEDPDEYVVLEVWEDEAAFEAHLQSPHFKAAH 74
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 7-89 6.23e-12

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


Pssm-ID: 441901  Cd Length: 98  Bit Score: 56.93  E-value: 6.23e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446593607   7 NRLTLTKGTAKDIIERLYTRHG-IETLEGFDGMFVTQTLEQEDfdEVKILTVWKSKQAFTDWLKSDVFKAAHKHVRSKNE 85
Cdd:COG2329    6 NRFRVKPGQEEEFEEAFAERRElLAEQPGFLGFELLRSLEDPG--EYLVVSYWESEEAFRAWFRSSEHRAAHAKGREILA 83


                 ....
gi 446593607  86 DESS 89
Cdd:COG2329   84 GPPR 87
PRK13316 PRK13316
heme oxygenase IsdG;
4-101 8.72e-09

heme oxygenase IsdG;


Pssm-ID: 183970  Cd Length: 121  Bit Score: 49.37  E-value: 8.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446593607   4 MAENRLTLTKGTAKDIIERLYTRHG-------IETLEGFDGMFVTQTL-EQEDFDEVKILTVWKSKQAFTDWLKSDVFKA 75
Cdd:PRK13316   3 IVTNTIKVEKGAAEHVIRQFTGANGdghptkdIAEVEGFLGFELWHSKpEDKDYEEVVVTSKWESEEAQRNWVKSDSFKK 82

                         90       100
                 ....*....|....*....|....*....
gi 446593607  76 AH---KHVRSKNEDESSpIINNKVITYDI 101
Cdd:PRK13316  83 AHgrtKDTREQREDRKG-IVGNAIARFEV 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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