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Conserved domains on  [gi|446592236|ref|WP_000669582|]
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MULTISPECIES: bi-component leukocidin LukMF' subunit F' [Bacilli]

Protein Classification

leukocidin/hemolysin toxin family protein( domain architecture ID 10017570)

leukocidin/hemolysin toxin family protein is a bi-component toxin that requires the synergistic association of class S and class F components to form hetero-oligomeric membrane-associated complexes that leads to the formation of lytic transmembrane pores with leucotoxic and hemolytic activities

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
hlyII TIGR01002
beta-channel forming cytolysin; This family of cytolytic pore-forming proteins includes alpha ...
6-315 5.59e-137

beta-channel forming cytolysin; This family of cytolytic pore-forming proteins includes alpha toxin and leukocidin F and S subunits from Staphylococcus aureus, hemolysin II of Bacillus cereus, and related toxins. [Cellular processes, Toxin production and resistance]


:

Pssm-ID: 273388  Cd Length: 312  Bit Score: 390.69  E-value: 5.59e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446592236    6 IVKSSVATSITLIMLSNTVDAAQHITP-VSEKKVDDKITLYKTTATSDSDKLKISQILTFNFIKDKSYDKDTLILKAAGN 84
Cdd:TIGR01002   2 ILLSATLTLVALVILSNPLTGAKTSTPkTSEEDIDDKITVYKSTATTSSDKLGITQSITFSFIKDKYYDKDTLIIKTAGN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446592236   85 IYSGYTQPTSDSSINSQFYWGAKYNVFVSSESKDSVNIVDYAPKNQNEEFQVQQTLGYSYGGDINII-NGLTGGLNGSKS 163
Cdd:TIGR01002  82 INSKYTKNNPDGTNNSGLYWPSAYNISILSESNNSVQIVDYAPKNTIETKQVQSTLGYSIGGSIEISeNKIGGSINGSFS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446592236  164 FSETINYKQESYRTTIDRKTNhKSIGWGVEAHKIMNNGWGPYGRDSSDSLYGNELFLGGRQSSSNANQNFLPTHQMPILA 243
Cdd:TIGR01002 162 FSETIKYVQPDYKTILEKHTD-KKIGWKVKFNSFVNAGWGPYGRDSFNPVYGNELFMKGRQSNLNATDNFLDDNQMPKLI 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446592236  244 RGNFNPEFISVLSHKQKDVKKSKIKVTYQREMDRYENFWNNLHWIGYNIKNQKRATHTSIYEIDWEKHTVKL 315
Cdd:TIGR01002 241 TGGFNPNFIAVLTADKNASKSSKIKVTYEREMDCYTLYWNSFNWVGTNYKDAFNATFTSTYKIDWKTHEVTL 312
 
Name Accession Description Interval E-value
hlyII TIGR01002
beta-channel forming cytolysin; This family of cytolytic pore-forming proteins includes alpha ...
6-315 5.59e-137

beta-channel forming cytolysin; This family of cytolytic pore-forming proteins includes alpha toxin and leukocidin F and S subunits from Staphylococcus aureus, hemolysin II of Bacillus cereus, and related toxins. [Cellular processes, Toxin production and resistance]


Pssm-ID: 273388  Cd Length: 312  Bit Score: 390.69  E-value: 5.59e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446592236    6 IVKSSVATSITLIMLSNTVDAAQHITP-VSEKKVDDKITLYKTTATSDSDKLKISQILTFNFIKDKSYDKDTLILKAAGN 84
Cdd:TIGR01002   2 ILLSATLTLVALVILSNPLTGAKTSTPkTSEEDIDDKITVYKSTATTSSDKLGITQSITFSFIKDKYYDKDTLIIKTAGN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446592236   85 IYSGYTQPTSDSSINSQFYWGAKYNVFVSSESKDSVNIVDYAPKNQNEEFQVQQTLGYSYGGDINII-NGLTGGLNGSKS 163
Cdd:TIGR01002  82 INSKYTKNNPDGTNNSGLYWPSAYNISILSESNNSVQIVDYAPKNTIETKQVQSTLGYSIGGSIEISeNKIGGSINGSFS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446592236  164 FSETINYKQESYRTTIDRKTNhKSIGWGVEAHKIMNNGWGPYGRDSSDSLYGNELFLGGRQSSSNANQNFLPTHQMPILA 243
Cdd:TIGR01002 162 FSETIKYVQPDYKTILEKHTD-KKIGWKVKFNSFVNAGWGPYGRDSFNPVYGNELFMKGRQSNLNATDNFLDDNQMPKLI 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446592236  244 RGNFNPEFISVLSHKQKDVKKSKIKVTYQREMDRYENFWNNLHWIGYNIKNQKRATHTSIYEIDWEKHTVKL 315
Cdd:TIGR01002 241 TGGFNPNFIAVLTADKNASKSSKIKVTYEREMDCYTLYWNSFNWVGTNYKDAFNATFTSTYKIDWKTHEVTL 312
Leukocidin pfam07968
Leukocidin/Hemolysin toxin family;
61-309 1.34e-99

Leukocidin/Hemolysin toxin family;


Pssm-ID: 429760  Cd Length: 253  Bit Score: 293.55  E-value: 1.34e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446592236   61 ILTFNFIKDKSYDKDTLILKAAGNIYSGYTQPTSDSSINSQFYWGAKYNVFVSSESKDSVNIVDYAPKNQNEEFQVQQTL 140
Cdd:pfam07968   1 SLQFDFIKDKTYDKKILVIKTDGSIASAGITLNPKGYNSSGLRWPSQYNVSFQATSNNKAQVLDYAPKNKIESAEVKSTL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446592236  141 GYSYGGDINII-NGLTGGLNGSKSFSETINYKQESYRTTIDRKTNHKsIGWGVEAHKIMNNGWGPYGRDSSDSLYGNELF 219
Cdd:pfam07968  81 GYELGGNVNDDgPGIGGGATGSFSYSETISYNQQDYRTELEAQTNKK-VGWGVEANSYNNPGWGPYGRDSFNPAYGNQLF 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446592236  220 LGGRqSSSNANQNFLPTHQMPILARGNFNPEFISVLSHKQKDVKKSKIKVTYQREMDRYEN----FWNNLHWIGYNIKNQ 295
Cdd:pfam07968 160 MRSR-SSLWARDNFVPKNQLPPLVRSGFNPEFIAVLSHEKGSTGKSEFEVTYSRNMDPYYNrykhHYVVGYWVGNNGKDF 238
                         250
                  ....*....|....
gi 446592236  296 KRATHTSIYEIDWE 309
Cdd:pfam07968 239 KNRTFSVTYEVDWK 252
 
Name Accession Description Interval E-value
hlyII TIGR01002
beta-channel forming cytolysin; This family of cytolytic pore-forming proteins includes alpha ...
6-315 5.59e-137

beta-channel forming cytolysin; This family of cytolytic pore-forming proteins includes alpha toxin and leukocidin F and S subunits from Staphylococcus aureus, hemolysin II of Bacillus cereus, and related toxins. [Cellular processes, Toxin production and resistance]


Pssm-ID: 273388  Cd Length: 312  Bit Score: 390.69  E-value: 5.59e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446592236    6 IVKSSVATSITLIMLSNTVDAAQHITP-VSEKKVDDKITLYKTTATSDSDKLKISQILTFNFIKDKSYDKDTLILKAAGN 84
Cdd:TIGR01002   2 ILLSATLTLVALVILSNPLTGAKTSTPkTSEEDIDDKITVYKSTATTSSDKLGITQSITFSFIKDKYYDKDTLIIKTAGN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446592236   85 IYSGYTQPTSDSSINSQFYWGAKYNVFVSSESKDSVNIVDYAPKNQNEEFQVQQTLGYSYGGDINII-NGLTGGLNGSKS 163
Cdd:TIGR01002  82 INSKYTKNNPDGTNNSGLYWPSAYNISILSESNNSVQIVDYAPKNTIETKQVQSTLGYSIGGSIEISeNKIGGSINGSFS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446592236  164 FSETINYKQESYRTTIDRKTNhKSIGWGVEAHKIMNNGWGPYGRDSSDSLYGNELFLGGRQSSSNANQNFLPTHQMPILA 243
Cdd:TIGR01002 162 FSETIKYVQPDYKTILEKHTD-KKIGWKVKFNSFVNAGWGPYGRDSFNPVYGNELFMKGRQSNLNATDNFLDDNQMPKLI 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446592236  244 RGNFNPEFISVLSHKQKDVKKSKIKVTYQREMDRYENFWNNLHWIGYNIKNQKRATHTSIYEIDWEKHTVKL 315
Cdd:TIGR01002 241 TGGFNPNFIAVLTADKNASKSSKIKVTYEREMDCYTLYWNSFNWVGTNYKDAFNATFTSTYKIDWKTHEVTL 312
Leukocidin pfam07968
Leukocidin/Hemolysin toxin family;
61-309 1.34e-99

Leukocidin/Hemolysin toxin family;


Pssm-ID: 429760  Cd Length: 253  Bit Score: 293.55  E-value: 1.34e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446592236   61 ILTFNFIKDKSYDKDTLILKAAGNIYSGYTQPTSDSSINSQFYWGAKYNVFVSSESKDSVNIVDYAPKNQNEEFQVQQTL 140
Cdd:pfam07968   1 SLQFDFIKDKTYDKKILVIKTDGSIASAGITLNPKGYNSSGLRWPSQYNVSFQATSNNKAQVLDYAPKNKIESAEVKSTL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446592236  141 GYSYGGDINII-NGLTGGLNGSKSFSETINYKQESYRTTIDRKTNHKsIGWGVEAHKIMNNGWGPYGRDSSDSLYGNELF 219
Cdd:pfam07968  81 GYELGGNVNDDgPGIGGGATGSFSYSETISYNQQDYRTELEAQTNKK-VGWGVEANSYNNPGWGPYGRDSFNPAYGNQLF 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446592236  220 LGGRqSSSNANQNFLPTHQMPILARGNFNPEFISVLSHKQKDVKKSKIKVTYQREMDRYEN----FWNNLHWIGYNIKNQ 295
Cdd:pfam07968 160 MRSR-SSLWARDNFVPKNQLPPLVRSGFNPEFIAVLSHEKGSTGKSEFEVTYSRNMDPYYNrykhHYVVGYWVGNNGKDF 238
                         250
                  ....*....|....
gi 446592236  296 KRATHTSIYEIDWE 309
Cdd:pfam07968 239 KNRTFSVTYEVDWK 252
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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