NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446584917|ref|WP_000662263|]
View 

MULTISPECIES: bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG [Bacteria]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 11454890)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

EC:  2.1.1.-
Gene Ontology:  GO:0032259|GO:0008168|GO:1904047
PubMed:  12504684|12826405

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 26-143 2.37e-33

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


:

Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 117.04  E-value: 2.37e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  26 AGAGEWET-LKKMLPDF--KGKRVLDLGCGYGWHCIYAMENGASsVVGVDISHKMLEVAKGKTHFPQIEYECCAIEDVDF 102
Cdd:COG2227    5 DARDFWDRrLAALLARLlpAGGRVLDVGCGTGRLALALARRGAD-VTGVDISPEALEIARERAAELNVDFVQGDLEDLPL 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 446584917 103 PEESFDVILSSLAFHYVADYENLIKKIYRMLKAGGNLVFTV 143
Cdd:COG2227   84 EDGSFDLVICSEVLEHLPDPAALLRELARLLKPGGLLLLST 124
 
Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 26-143 2.37e-33

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 117.04  E-value: 2.37e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  26 AGAGEWET-LKKMLPDF--KGKRVLDLGCGYGWHCIYAMENGASsVVGVDISHKMLEVAKGKTHFPQIEYECCAIEDVDF 102
Cdd:COG2227    5 DARDFWDRrLAALLARLlpAGGRVLDVGCGTGRLALALARRGAD-VTGVDISPEALEIARERAAELNVDFVQGDLEDLPL 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 446584917 103 PEESFDVILSSLAFHYVADYENLIKKIYRMLKAGGNLVFTV 143
Cdd:COG2227   84 EDGSFDLVICSEVLEHLPDPAALLRELARLLKPGGLLLLST 124
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 47-141 7.20e-32

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 112.37  E-value: 7.20e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917   47 LDLGCGYGWHCIYAMENGASsVVGVDISHKMLEVAKGKTHFPQIEYECCAIEDVDFPEESFDVILSSLAFHYVADYENLI 126
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGAR-VTGVDISPEMLELAREKAPREGLTFVVGDAEDLPFPDNSFDLVLSSEVLHHVEDPERAL 79

                          90
                  ....*....|....*
gi 446584917  127 KKIYRMLKAGGNLVF 141
Cdd:pfam08241  80 REIARVLKPGGILII 94
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 45-145 1.99e-20

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 82.86  E-value: 1.99e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  45 RVLDLGCGYGWHCIYAMENGASSVVGVDISHKMLEVAKGKT---HFPQIEYECCAIEDVDF-PEESFDVILSSLAFHY-V 119
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAaalLADNVEVLKGDAEELPPeADESFDVIISDPPLHHlV 80

                         90       100
                 ....*....|....*....|....*.
gi 446584917 120 ADYENLIKKIYRMLKAGGNLVFTVEH 145
Cdd:cd02440   81 EDLARFLEEARRLLKPGGVLVLTLVL 106
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 38-142 1.74e-17

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 78.48  E-value: 1.74e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917   38 LPDFKGKRVLDLGCGYGWHC-IYAMENGASSVVGVDISHKMLEVAKgKTHFPQIEYECCAIEDVDFPEESFDVILSSLAF 116
Cdd:TIGR02072  30 KGIFIPASVLDIGCGTGYLTrALLKRFPQAEFIALDISAGMLAQAK-TKLSENVQFICGDAEKLPLEDSSFDLIVSNLAL 108

                          90       100
                  ....*....|....*....|....*.
gi 446584917  117 HYVADYENLIKKIYRMLKAGGNLVFT 142
Cdd:TIGR02072 109 QWCDDLSQALSELARVLKPGGLLAFS 134
PRK08317 PRK08317
hypothetical protein; Provisional
 42-140 4.03e-17

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 77.67  E-value: 4.03e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  42 KGKRVLDLGCGYGWHCIY-AMENGASS-VVGVDISHKMLEVAKGKT--HFPQIEYECCAIEDVDFPEESFDVILSSLAFH 117
Cdd:PRK08317  19 PGDRVLDVGCGPGNDARElARRVGPEGrVVGIDRSEAMLALAKERAagLGPNVEFVRGDADGLPFPDGSFDAVRSDRVLQ 98

                         90       100
                 ....*....|....*....|...
gi 446584917 118 YVADYENLIKKIYRMLKAGGNLV 140
Cdd:PRK08317  99 HLEDPARALAEIARVLRPGGRVV 121
 
Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 26-143 2.37e-33

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 117.04  E-value: 2.37e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  26 AGAGEWET-LKKMLPDF--KGKRVLDLGCGYGWHCIYAMENGASsVVGVDISHKMLEVAKGKTHFPQIEYECCAIEDVDF 102
Cdd:COG2227    5 DARDFWDRrLAALLARLlpAGGRVLDVGCGTGRLALALARRGAD-VTGVDISPEALEIARERAAELNVDFVQGDLEDLPL 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 446584917 103 PEESFDVILSSLAFHYVADYENLIKKIYRMLKAGGNLVFTV 143
Cdd:COG2227   84 EDGSFDLVICSEVLEHLPDPAALLRELARLLKPGGLLLLST 124
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 28-146 4.59e-32

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 114.32  E-value: 4.59e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  28 AGEWETLKKM---LPDFKGKRVLDLGCGYGWHCIYAMENGASsVVGVDISHKMLEVAKGKT--HFPQIEYECCAIEDVDF 102
Cdd:COG2226    5 AARYDGREALlaaLGLRPGARVLDLGCGTGRLALALAERGAR-VTGVDISPEMLELARERAaeAGLNVEFVVGDAEDLPF 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 446584917 103 PEESFDVILSSLAFHYVADYENLIKKIYRMLKAGGNLVFTVEHP 146
Cdd:COG2226   84 PDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSP 127
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 47-141 7.20e-32

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 112.37  E-value: 7.20e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917   47 LDLGCGYGWHCIYAMENGASsVVGVDISHKMLEVAKGKTHFPQIEYECCAIEDVDFPEESFDVILSSLAFHYVADYENLI 126
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGAR-VTGVDISPEMLELAREKAPREGLTFVVGDAEDLPFPDNSFDLVLSSEVLHHVEDPERAL 79

                          90
                  ....*....|....*
gi 446584917  127 KKIYRMLKAGGNLVF 141
Cdd:pfam08241  80 REIARVLKPGGILII 94
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 46-137 9.73e-31

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 109.58  E-value: 9.73e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917   46 VLDLGCGYGWHCIYAMENGASSVVGVDISHKMLEVAKGK--THFPQIEYECCAIEDVDFPEESFDVILSSLAFHYV--AD 121
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERaaEAGLNVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLpdPD 80

                          90
                  ....*....|....*.
gi 446584917  122 YENLIKKIYRMLKAGG 137
Cdd:pfam13649  81 LEAALREIARVLKPGG 96
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
3-145 9.37e-28

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 104.31  E-value: 9.37e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917   3 ENKYDDniFFQKYSQMSRSQKGLAGAGEW-ETLKKMLPDFKGKRVLDLGCGYGwHCIYAMENGASSVVGVDISHKMLEVA 81
Cdd:COG4976    8 EALFDQ--YADSYDAALVEDLGYEAPALLaEELLARLPPGPFGRVLDLGCGTG-LLGEALRPRGYRLTGVDLSEEMLAKA 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446584917  82 KGKTHfpQIEYECCAIEDVDFPEESFDVILSSLAFHYVADYENLIKKIYRMLKAGGNLVFTVEH 145
Cdd:COG4976   85 REKGV--YDRLLVADLADLAEPDGRFDLIVAADVLTYLGDLAAVFAGVARALKPGGLFIFSVED 146
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
42-143 1.50e-26

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 98.74  E-value: 1.50e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  42 KGKRVLDLGCGYGWHCIY-AMENGASSVVGVDISHKMLEVAKgkTHFPQIEYECCAIEDVDfPEESFDVILSSLAFHYVA 120
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALlAERFPGARVTGVDLSPEMLARAR--ARLPNVRFVVADLRDLD-PPEPFDLVVSNAALHWLP 77

                         90       100
                 ....*....|....*....|...
gi 446584917 121 DYENLIKKIYRMLKAGGNLVFTV 143
Cdd:COG4106   78 DHAALLARLAAALAPGGVLAVQV 100
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 43-143 8.63e-22

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 88.06  E-value: 8.63e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  43 GKRVLDLGCGYGWHCIYAMENGASSVVGVDISHKMLEVAK------GKTHfpQIEYECCAIEDVDfPEESFDVILSSLAF 116
Cdd:COG2230   52 GMRVLDIGCGWGGLALYLARRYGVRVTGVTLSPEQLEYAReraaeaGLAD--RVEVRLADYRDLP-ADGQFDAIVSIGMF 128

                         90       100
                 ....*....|....*....|....*....
gi 446584917 117 HYV--ADYENLIKKIYRMLKAGGNLVFTV 143
Cdd:COG2230  129 EHVgpENYPAYFAKVARLLKPGGRLLLHT 157
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 45-145 1.99e-20

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 82.86  E-value: 1.99e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  45 RVLDLGCGYGWHCIYAMENGASSVVGVDISHKMLEVAKGKT---HFPQIEYECCAIEDVDF-PEESFDVILSSLAFHY-V 119
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAaalLADNVEVLKGDAEELPPeADESFDVIISDPPLHHlV 80

                         90       100
                 ....*....|....*....|....*.
gi 446584917 120 ADYENLIKKIYRMLKAGGNLVFTVEH 145
Cdd:cd02440   81 EDLARFLEEARRLLKPGGVLVLTLVL 106
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 37-167 7.97e-19

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 80.55  E-value: 7.97e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917   37 MLPDFKGKRVLDLGCGYGWHCIYAMENGASsVVGVDISHKMLEVAKgkthfPQIEYECCAIEDVDFPEESFDVILSSLAF 116
Cdd:pfam13489  17 LPKLPSPGRVLDFGCGTGIFLRLLRAQGFS-VTGVDPSPIAIERAL-----LNVRFDQFDEQEAAVPAGKFDVIVAREVL 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 446584917  117 HYVADYENLIKKIYRMLKAGGNLVF-TVEHPVFTAHGTQDWYY-NEKGEILHF 167
Cdd:pfam13489  91 EHVPDPPALLRQIAALLKPGGLLLLsTPLASDEADRLLLEWPYlRPRNGHISL 143
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 42-142 4.13e-18

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 79.58  E-value: 4.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  42 KGKRVLDLGCGYGWHCIYAMENGASSVVGVDISHKMLEVAK---GKTHFPQIEYECC-AIEDVDFPEESFDVILSSLAFH 117
Cdd:COG0500   26 KGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARaraAKAGLGNVEFLVAdLAELDPLPAESFDLVVAFGVLH 105

                         90       100
                 ....*....|....*....|....*..
gi 446584917 118 YV--ADYENLIKKIYRMLKAGGNLVFT 142
Cdd:COG0500  106 HLppEEREALLRELARALKPGGVLLLS 132
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 38-142 1.74e-17

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 78.48  E-value: 1.74e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917   38 LPDFKGKRVLDLGCGYGWHC-IYAMENGASSVVGVDISHKMLEVAKgKTHFPQIEYECCAIEDVDFPEESFDVILSSLAF 116
Cdd:TIGR02072  30 KGIFIPASVLDIGCGTGYLTrALLKRFPQAEFIALDISAGMLAQAK-TKLSENVQFICGDAEKLPLEDSSFDLIVSNLAL 108

                          90       100
                  ....*....|....*....|....*.
gi 446584917  117 HYVADYENLIKKIYRMLKAGGNLVFT 142
Cdd:TIGR02072 109 QWCDDLSQALSELARVLKPGGLLAFS 134
PRK08317 PRK08317
hypothetical protein; Provisional
 42-140 4.03e-17

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 77.67  E-value: 4.03e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  42 KGKRVLDLGCGYGWHCIY-AMENGASS-VVGVDISHKMLEVAKGKT--HFPQIEYECCAIEDVDFPEESFDVILSSLAFH 117
Cdd:PRK08317  19 PGDRVLDVGCGPGNDARElARRVGPEGrVVGIDRSEAMLALAKERAagLGPNVEFVRGDADGLPFPDGSFDAVRSDRVLQ 98

                         90       100
                 ....*....|....*....|...
gi 446584917 118 YVADYENLIKKIYRMLKAGGNLV 140
Cdd:PRK08317  99 HLEDPARALAEIARVLRPGGRVV 121
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 47-139 6.05e-16

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 70.86  E-value: 6.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917   47 LDLGCGYG---WHCiyAMENGASSVVGVDISHKMLEVAKGKT------HFPQIEYECCAIEDVDFPeeSFDVILSSLAFH 117
Cdd:pfam08242   1 LEIGCGTGtllRAL--LEALPGLEYTGLDISPAALEAARERLaalgllNAVRVELFQLDLGELDPG--SFDVVVASNVLH 76

                          90       100
                  ....*....|....*....|..
gi 446584917  118 YVADYENLIKKIYRMLKAGGNL 139
Cdd:pfam08242  77 HLADPRAVLRNIRRLLKPGGVL 98
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 42-148 6.28e-15

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 69.75  E-value: 6.28e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917   42 KGKRVLDLGCGYGWHCIYAME--NGASSVVGVDISHKMLEVAKG---KTHFPQIEYECCAIEDVD--FPEESFDVILSSL 114
Cdd:pfam13847   3 KGMRVLDLGCGTGHLSFELAEelGPNAEVVGIDISEEAIEKAREnaqKLGFDNVEFEQGDIEELPelLEDDKFDVVISNC 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 446584917  115 AFHYVADYENLIKKIYRMLKAGGnlVFTVEHPVF 148
Cdd:pfam13847  83 VLNHIPDPDKVLQEILRVLKPGG--RLIISDPDS 114
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 36-159 7.97e-15

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 71.34  E-value: 7.97e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  36 KMLPDFKGKRVLDLGCGYG-WHCIYAMENGAS-SVVGVDISHKMLEVAKGKTH----FPQIEYECCAIEDVDFPEESFDV 109
Cdd:PRK00216  45 KWLGVRPGDKVLDLACGTGdLAIALAKAVGKTgEVVGLDFSEGMLAVGREKLRdlglSGNVEFVQGDAEALPFPDNSFDA 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446584917 110 IlsSLAF--HYVADYENLIKKIYRMLKAGGNLV---FT-VEHPVFTAhgTQDWYYN 159
Cdd:PRK00216 125 V--TIAFglRNVPDIDKALREMYRVLKPGGRLVileFSkPTNPPLKK--AYDFYLF 176
PTZ00098 PTZ00098
phosphoethanolamine N-methyltransferase; Provisional
 28-142 1.29e-12

phosphoethanolamine N-methyltransferase; Provisional


Pssm-ID: 173391 [Multi-domain]  Cd Length: 263  Bit Score: 65.38  E-value: 1.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  28 AGEWETLKKMLPDFK---GKRVLDLGCGYGWHCIYAMENGASSVVGVDISHKMLEVAKGKTH-FPQIEYECCAIEDVDFP 103
Cdd:PTZ00098  35 SGGIEATTKILSDIElneNSKVLDIGSGLGGGCKYINEKYGAHVHGVDICEKMVNIAKLRNSdKNKIEFEANDILKKDFP 114

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 446584917 104 EESFDVILSSLAFHYV--ADYENLIKKIYRMLKAGGNLVFT 142
Cdd:PTZ00098 115 ENTFDMIYSRDAILHLsyADKKKLFEKCYKWLKPNGILLIT 155
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
37-112 5.64e-12

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 62.61  E-value: 5.64e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446584917  37 MLPDFKGKRVLDLGCGYGWHCIYAMENGASSVVGVDISHKMLEVAK--GKTHFPQIEYECCAIEDVDfPEESFDVILS 112
Cdd:COG2263   40 LRGDIEGKTVLDLGCGTGMLAIGAALLGAKKVVGVDIDPEALEIARenAERLGVRVDFIRADVTRIP-LGGSVDTVVM 116
arsM PRK11873
arsenite methyltransferase;
42-140 8.34e-12

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 63.43  E-value: 8.34e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  42 KGKRVLDLGCGYGWHCIYAM-ENGAS-SVVGVDISHKMLEVAKG---KTHFPQIEYECCAIEDVDFPEESFDVILSSLAF 116
Cdd:PRK11873  77 PGETVLDLGSGGGFDCFLAArRVGPTgKVIGVDMTPEMLAKARAnarKAGYTNVEFRLGEIEALPVADNSVDVIISNCVI 156

                         90       100
                 ....*....|....*....|....
gi 446584917 117 HYVADYENLIKKIYRMLKAGGNLV 140
Cdd:PRK11873 157 NLSPDKERVFKEAFRVLKPGGRFA 180
PRK15068 PRK15068
tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;
31-140 1.35e-11

tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;


Pssm-ID: 237898  Cd Length: 322  Bit Score: 62.95  E-value: 1.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  31 WETLKKMLPDFKGKRVLDLGCGYGWHCiYAM-ENGASSVVGVDISHKML---EVAKgktHF----PQIEYECCAIEDVDf 102
Cdd:PRK15068 111 WDRVLPHLSPLKGRTVLDVGCGNGYHM-WRMlGAGAKLVVGIDPSQLFLcqfEAVR---KLlgndQRAHLLPLGIEQLP- 185

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446584917 103 PEESFDVILSSLAFHYVADYENLIKKIYRMLKAGGNLV 140
Cdd:PRK15068 186 ALKAFDTVFSMGVLYHRRSPLDHLKQLKDQLVPGGELV 223
PLN02336 PLN02336
phosphoethanolamine N-methyltransferase
 24-142 1.50e-11

phosphoethanolamine N-methyltransferase


Pssm-ID: 177970 [Multi-domain]  Cd Length: 475  Bit Score: 63.62  E-value: 1.50e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  24 GLAGAGEWETLKKMLP--DFK-GKRVLDLGCGYGWHCIYAMENGASSVVGVDISHKM----LEVAKGKTHFpqIEYECCA 96
Cdd:PLN02336 245 GFVSTGGLETTKEFVDklDLKpGQKVLDVGCGIGGGDFYMAENFDVHVVGIDLSVNMisfaLERAIGRKCS--VEFEVAD 322

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 446584917  97 IEDVDFPEESFDVILSSLAFHYVADYENLIKKIYRMLKAGGNLVFT 142
Cdd:PLN02336 323 CTKKTYPDNSFDVIYSRDTILHIQDKPALFRSFFKWLKPGGKVLIS 368
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
36-140 1.80e-11

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 61.69  E-value: 1.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917   36 KMLPDFKGKRVLDLGCGYG-WHCIYAMENGAS-SVVGVDISHKMLEVAKGKTH---FPQIEYECCAIEDVDFPEESFDVI 110
Cdd:pfam01209  36 KCMGVKRGNKFLDVAGGTGdWTFGLSDSAGSSgKVVGLDINENMLKEGEKKAKeegKYNIEFLQGNAEELPFEDDSFDIV 115

                          90       100       110
                  ....*....|....*....|....*....|
gi 446584917  111 LSSLAFHYVADYENLIKKIYRMLKAGGNLV 140
Cdd:pfam01209 116 TISFGLRNFPDYLKVLKEAFRVLKPGGRVV 145
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 13-142 1.82e-11

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 62.08  E-value: 1.82e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  13 QKYSQMSRSQKGLAGAgewetLKKMLPDFKGKRVLDLGCGYGWHCIYAMENGaSSVVGVDISHKMLEVA--KGKTHfpqi 90
Cdd:PRK10258  18 AHYEQHAELQRQSADA-----LLAMLPQRKFTHVLDAGCGPGWMSRYWRERG-SQVTALDLSPPMLAQArqKDAAD---- 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446584917  91 EYECCAIEDVDFPEESFDVILSSLAFHYVADYENLIKKIYRMLKAGGNLVFT 142
Cdd:PRK10258  88 HYLAGDIESLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPGGVVAFT 139
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 38-141 1.93e-10

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 58.28  E-value: 1.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  38 LPDFKGKRVLDLGCGYGW-HCIYAMENGASSVVGVDISHKMLEVAKG--KTHfpqieyeccAIEDVDF---------PEE 105
Cdd:COG2813   45 LPEPLGGRVLDLGCGYGViGLALAKRNPEARVTLVDVNARAVELARAnaAAN---------GLENVEVlwsdglsgvPDG 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 446584917 106 SFDVILSSLAFH--YVADYE---NLIKKIYRMLKAGGNLVF 141
Cdd:COG2813  116 SFDLILSNPPFHagRAVDKEvahALIADAARHLRPGGELWL 156
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 42-141 2.02e-08

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 54.03  E-value: 2.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  42 KGKRVLDL---GCGYGwhcIYAMENGASSVVGVDISHKMLEVAK---------GKTHFpqIEYECCA-IEDVDFPEESFD 108
Cdd:COG1092  216 KGKRVLNLfsyTGGFS---VHAAAGGAKSVTSVDLSATALEWAKenaalngldDRHEF--VQADAFDwLRELAREGERFD 290

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 446584917 109 VILS---SLA------FHYVADYENLIKKIYRMLKAGGNLVF 141
Cdd:COG1092  291 LIILdppAFAkskkdlFDAQRDYKDLNRLALKLLAPGGILVT 332
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 38-139 2.13e-08

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 52.21  E-value: 2.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917   38 LPDFKGKRVLDLGCGYGWHCIY-AMENGASSVVGVDISHKMLEVAKGKTHFPQIEYECCAIEDV--DFPEESFDVILSSL 114
Cdd:pfam05175  27 LPKDLSGKVLDLGCGAGVLGAAlAKESPDAELTMVDINARALESARENLAANGLENGEVVASDVysGVEDGKFDLIISNP 106

                          90       100       110
                  ....*....|....*....|....*....|
gi 446584917  115 AFH--YVADY---ENLIKKIYRMLKAGGNL 139
Cdd:pfam05175 107 PFHagLATTYnvaQRFIADAKRHLRPGGEL 136
Methyltransf_9 pfam08003
Protein of unknown function (DUF1698); This family contains many hypothetical proteins. It ...
 31-140 4.35e-08

Protein of unknown function (DUF1698); This family contains many hypothetical proteins. It also includes two putative methyltransferase proteins, Swiss:Q8EEE6 and Swiss:Q88MX8.


Pssm-ID: 429781 [Multi-domain]  Cd Length: 315  Bit Score: 52.79  E-value: 4.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917   31 WETLKKMLPDFKGKRVLDLGCGYGWHCIYAMENGASSVVGVDIS----------HKMLEVAKGKTHFPqieyecCAIEDV 100
Cdd:pfam08003 104 WDRVLPHLSPLKGRTILDVGCGNGYHMWRMLGEGAAMVVGIDPSelflcqfeavRKLLGNDQRAHLLP------LGIEQL 177

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 446584917  101 DfPEESFDVILS-SLAFHYVADYENLIkKIYRMLKAGGNLV 140
Cdd:pfam08003 178 P-ALAAFDTVFSmGVLYHRRSPLDHLL-QLKDQLVKGGELV 216
COG2521 COG2521
Predicted archaeal methyltransferase [General function prediction only];
42-139 6.62e-08

Predicted archaeal methyltransferase [General function prediction only];


Pssm-ID: 442011 [Multi-domain]  Cd Length: 285  Bit Score: 52.22  E-value: 6.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  42 KGKRVLDLGCGYGWHCIYAMENGASSVVGVDISHKMLEVAK-----GKTHFPQIEYECCAIEDV--DFPEESFDVI---- 110
Cdd:COG2521  132 RGDRVLDTCTGLGYTAIEALKRGAREVITVEKDPNVLELAElnpwsRELANERIKIILGDASEVikTFPDESFDAIihdp 211

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446584917 111 --------LSSLAFhyvadYENLikkiYRMLKAGGNL 139
Cdd:COG2521  212 prfslageLYSLEF-----YREL----YRVLKPGGRL 239
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 38-143 1.83e-07

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 50.22  E-value: 1.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  38 LPDFKGKRVLDLGCGYGWHCIYAMENGAsSVVGVDISHKMLEVAK---GKTHFP-QIEYECCAIEDVDfpeESFDVI--L 111
Cdd:PRK07580  59 DGDLTGLRILDAGCGVGSLSIPLARRGA-KVVASDISPQMVEEAReraPEAGLAgNITFEVGDLESLL---GRFDTVvcL 134

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446584917 112 SSLaFHYVADyenlikKIYRMLK-----AGGNLVFTV 143
Cdd:PRK07580 135 DVL-IHYPQE------DAARMLAhlaslTRGSLIFTF 164
PLN02336 PLN02336
phosphoethanolamine N-methyltransferase
 37-141 3.01e-07

phosphoethanolamine N-methyltransferase


Pssm-ID: 177970 [Multi-domain]  Cd Length: 475  Bit Score: 50.52  E-value: 3.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  37 MLPDFKGKRVLDLGCGYGwHCIYAMENGASSVVGVDISHKML---EVAKGktHFPQIEYECCAI--EDVDFPEESFDVIL 111
Cdd:PLN02336  32 LLPPYEGKSVLELGAGIG-RFTGELAKKAGQVIALDFIESVIkknESING--HYKNVKFMCADVtsPDLNISDGSVDLIF 108

                         90       100       110
                 ....*....|....*....|....*....|..
gi 446584917 112 SSLAFHYVADYE--NLIKKIYRMLKAGGNLVF 141
Cdd:PLN02336 109 SNWLLMYLSDKEveNLAERMVKWLKVGGYIFF 140
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 43-137 3.38e-07

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 50.02  E-value: 3.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917   43 GKRVLDLGCGYGWHCIYAMENGASSVVGVDISHKMLEVAK------GKTHFPQIEYecCAIEDVDfpeESFDVILSSLAF 116
Cdd:pfam02353  62 GMTLLDIGCGWGGLMRRAAERYDVNVVGLTLSKNQYKLARkrvaaeGLARKVEVLL--QDYRDFD---EPFDRIVSVGMF 136

                          90       100
                  ....*....|....*....|...
gi 446584917  117 HYV--ADYENLIKKIYRMLKAGG 137
Cdd:pfam02353 137 EHVghENYDTFFKKLYNLLPPGG 159
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 39-137 3.65e-07

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 49.50  E-value: 3.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  39 PDFKGKRVLDLGCGYGWHCIYAMENGASSVVGVDISHKMLEVAK---GKTHFPqIEYECCAIEDVDfPEESFDVILssla 115
Cdd:COG3897   67 PEVAGKRVLELGCGLGLVGIAAAKAGAADVTATDYDPEALAALRlnaALNGVA-ITTRLGDWRDPP-AAGGFDLIL---- 140

                         90       100
                 ....*....|....*....|....*....
gi 446584917 116 fhyVAD--YEN-----LIKKIYRMLKAGG 137
Cdd:COG3897  141 ---GGDvlYERdlaepLLPFLDRLAAPGG 166
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 42-147 3.97e-07

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 48.79  E-value: 3.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  42 KGKRVLDLGCGYGWHCIYAMENGASsVVGVDISHKMLEVAKGKT---HFPQIEYECCAIEDVDFPEESFDVIL------- 111
Cdd:COG1041   26 EGDTVLDPFCGTGTILIEAGLLGRR-VIGSDIDPKMVEGARENLehyGYEDADVIRGDARDLPLADESVDAIVtdppygr 104

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446584917 112 -SSLAFHYVAD-YENLIKKIYRMLKAGGNLVFTVEHPV 147
Cdd:COG1041  105 sSKISGEELLElYEKALEEAARVLKPGGRVVIVTPRDI 142
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 32-145 1.10e-06

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 48.23  E-value: 1.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  32 ETLKKMLPDFKGKRVLDLGCGYGwhCI---YAMENGASSVVGVDISHKMLEVAKG---KTHFPQIEYECCaieDV--DFP 103
Cdd:PRK09328  98 EWALEALLLKEPLRVLDLGTGSG--AIalaLAKERPDAEVTAVDISPEALAVARRnakHGLGARVEFLQG---DWfePLP 172

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446584917 104 EESFDVILS------SLAFHYV--------------------ADYENLIKKIYRMLKAGGNLVFtvEH 145
Cdd:PRK09328 173 GGRFDLIVSnppyipEADIHLLqpevrdhephlalfggedglDFYRRIIEQAPRYLKPGGWLLL--EI 238
PRK01683 PRK01683
trans-aconitate 2-methyltransferase; Provisional
 39-139 1.27e-06

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 234970  Cd Length: 258  Bit Score: 48.02  E-value: 1.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  39 PDFKGKRVLDLGCGYG---------WhciyamenGASSVVGVDISHKMLEVAkgKTHFPQieyecCAIEDVDF----PEE 105
Cdd:PRK01683  28 PLENPRYVVDLGCGPGnstellverW--------PAARITGIDSSPAMLAEA--RSRLPD-----CQFVEADIaswqPPQ 92

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446584917 106 SFDVILSSLAFHYVADYENLIKKIYRMLKAGGNL 139
Cdd:PRK01683  93 ALDLIFANASLQWLPDHLELFPRLVSLLAPGGVL 126
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 42-141 2.83e-06

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 47.26  E-value: 2.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917   42 KGKRVLDLGCGYGWHCIYAMENGASSVVGVDISHKMLEVAKGKTHFPQIEYECCAIEDVDFPEESFDVILSSLafhyVAD 121
Cdd:pfam06325 161 PGESVLDVGCGSGILAIAALKLGAKKVVGVDIDPVAVRAAKENAELNGVEARLEVYLPGDLPKEKADVVVANI----LAD 236

                          90       100
                  ....*....|....*....|.
gi 446584917  122 -YENLIKKIYRMLKAGGNLVF 141
Cdd:pfam06325 237 pLIELAPDIYALVKPGGYLIL 257
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 36-145 1.80e-05

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 44.76  E-value: 1.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  36 KMLPDFKGKRVLDLGCGYGwhCI---YAMENGASSVVGVDISHKMLEVAKG--KTHfpqieyecCAIEDVDF-------- 102
Cdd:COG2890  106 ALLPAGAPPRVLDLGTGSG--AIalaLAKERPDARVTAVDISPDALAVARRnaERL--------GLEDRVRFlqgdlfep 175

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446584917 103 --PEESFDVILS------SLAFHY----VADYE------------NLIKKI----YRMLKAGGNLVFtvEH 145
Cdd:COG2890  176 lpGDGRFDLIVSnppyipEDEIALlppeVRDHEprlaldggedglDFYRRIiaqaPRLLKPGGWLLL--EI 244
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
42-140 2.46e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 44.26  E-value: 2.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  42 KGKRVLDLGCGYGWHCIYAMENGASSVVGVDISHKMLEVAK------GKTHfpQIEYECCAIEDVDFPEEsFDVILSSLA 115
Cdd:COG4076   35 PGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARriiaanGLSD--RITVINADATDLDLPEK-ADVIISEML 111

                         90       100       110
                 ....*....|....*....|....*....|.
gi 446584917 116 FHY------VADYENLIKkiyRMLKAGGNLV 140
Cdd:COG4076  112 DTAlldegqVPILNHARK---RLLKPGGRII 139
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 42-156 2.81e-05

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 44.11  E-value: 2.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  42 KGKRVLDLGCGYGWHCIYAMENGASS--VVGVDISHKMLEVA------KGKTHFPQIEY-ECCAIeDVDFPEESFDVILS 112
Cdd:PLN02233  73 MGDRVLDLCCGSGDLAFLLSEKVGSDgkVMGLDFSSEQLAVAasrqelKAKSCYKNIEWiEGDAT-DLPFDDCYFDAITM 151

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 446584917 113 SLAFHYVADYENLIKKIYRMLKAGGN---LVFTVEHPVFTAHgTQDW 156
Cdd:PLN02233 152 GYGLRNVVDRLKAMQEMYRVLKPGSRvsiLDFNKSTQPFTTS-MQEW 197
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 42-141 4.01e-05

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 43.59  E-value: 4.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  42 KGKRVLDLGCGygwhC-----IYAMENGASSVVGVDISHKMLEVAK------GKTHfpQIEYECCAIEDV--DFPEESFD 108
Cdd:COG4123   37 KGGRVLDLGTG----TgvialMLAQRSPGARITGVEIQPEAAELARrnvalnGLED--RITVIHGDLKEFaaELPPGSFD 110

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446584917 109 VILS------------------SLAFHYVA-DYENLIKKIYRMLKAGGNLVF 141
Cdd:COG4123  111 LVVSnppyfkagsgrkspdearAIARHEDAlTLEDLIRAAARLLKPGGRFAL 162
PRK11705 PRK11705
cyclopropane fatty acyl phospholipid synthase;
43-137 6.05e-05

cyclopropane fatty acyl phospholipid synthase;


Pssm-ID: 183282  Cd Length: 383  Bit Score: 43.30  E-value: 6.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  43 GKRVLDLGCGYGWHCIYAMENGASSVVGVDISHKMLEVAKgkthfpqieyECCAIEDVDFP-------EESFDVILSSLA 115
Cdd:PRK11705 168 GMRVLDIGCGWGGLARYAAEHYGVSVVGVTISAEQQKLAQ----------ERCAGLPVEIRlqdyrdlNGQFDRIVSVGM 237

                         90       100
                 ....*....|....*....|....
gi 446584917 116 FHYVA--DYENLIKKIYRMLKAGG 137
Cdd:PRK11705 238 FEHVGpkNYRTYFEVVRRCLKPDG 261
PRK14968 PRK14968
putative methyltransferase; Provisional
 34-82 8.05e-05

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 42.19  E-value: 8.05e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 446584917  34 LKKMLPDFKGKRVLDLGCGYGWHCIYAMENGAsSVVGVDISHKMLEVAK 82
Cdd:PRK14968  15 LAENAVDKKGDRVLEVGTGSGIVAIVAAKNGK-KVVGVDINPYAVECAK 62
FtsJ pfam01728
FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal ...
 42-140 8.70e-05

FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.


Pssm-ID: 426399  Cd Length: 179  Bit Score: 41.81  E-value: 8.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917   42 KGKRVLDLGCGYG-WhCIYAMENGASSVVGVDISHKMLEVAKGKTHFPQIEYECCAIEDVDFPEE----SFDVILSSLAF 116
Cdd:pfam01728  21 PGKTVLDLGAAPGgW-SQVALQRGAGKVVGVDLGPMQLWKPRNDPGVTFIQGDIRDPETLDLLEEllgrKVDLVLSDGSP 99

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 446584917  117 ----HYVADYEN---LIKK----IYRMLKAGGNLV 140
Cdd:pfam01728 100 fisgNKVLDHLRsldLVKAalevALELLRKGGNFV 134
PRK14103 PRK14103
trans-aconitate 2-methyltransferase; Provisional
 39-143 9.22e-05

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 184509  Cd Length: 255  Bit Score: 42.37  E-value: 9.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  39 PDFKGKRVLDLGCGYGWHCIYAMENGASSVV-GVDISHKMLEVAKGkthfPQIEYECCAIEDVDfPEESFDVILSSLAFH 117
Cdd:PRK14103  26 GAERARRVVDLGCGPGNLTRYLARRWPGAVIeALDSSPEMVAAARE----RGVDARTGDVRDWK-PKPDTDVVVSNAALQ 100

                         90       100
                 ....*....|....*....|....*.
gi 446584917 118 YVADYENLIKKIYRMLKAGGNLVFTV 143
Cdd:PRK14103 101 WVPEHADLLVRWVDELAPGSWIAVQV 126
PRK05785 PRK05785
hypothetical protein; Provisional
 42-131 9.40e-05

hypothetical protein; Provisional


Pssm-ID: 235607 [Multi-domain]  Cd Length: 226  Bit Score: 42.37  E-value: 9.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  42 KGKRVLDLGCGYG--WHCIYAMENgaSSVVGVDISHKMLEVAKGKThfpqiEYECCAIEDVDFPEESFDVILSSLAFHYV 119
Cdd:PRK05785  51 RPKKVLDVAAGKGelSYHFKKVFK--YYVVALDYAENMLKMNLVAD-----DKVVGSFEALPFRDKSFDVVMSSFALHAS 123

                         90
                 ....*....|..
gi 446584917 120 ADYENLIKKIYR 131
Cdd:PRK05785 124 DNIEKVIAEFTR 135
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
40-141 2.61e-04

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 41.29  E-value: 2.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  40 DFKGKRVLDLGCGYGWHCIYAMENGASSVVGVDISHKMLEVAKGKTHFPQIEyeccaiEDVDFPE--ESFDVILSSLafh 117
Cdd:PRK00517 117 VLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVDIDPQAVEAARENAELNGVE------LNVYLPQgdLKADVIVANI--- 187

                         90       100
                 ....*....|....*....|....*
gi 446584917 118 yVAD-YENLIKKIYRMLKAGGNLVF 141
Cdd:PRK00517 188 -LANpLLELAPDLARLLKPGGRLIL 211
PLN02490 PLN02490
MPBQ/MSBQ methyltransferase
 45-148 3.39e-04

MPBQ/MSBQ methyltransferase


Pssm-ID: 215270 [Multi-domain]  Cd Length: 340  Bit Score: 41.03  E-value: 3.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  45 RVLDLGCGYGWHCIYAMEN-GASSVVGVDISHKMLEVAKGKTHFPqieyECCAIE----DVDFPEESFDVILSSLAFHYV 119
Cdd:PLN02490 116 KVVDVGGGTGFTTLGIVKHvDAKNVTILDQSPHQLAKAKQKEPLK----ECKIIEgdaeDLPFPTDYADRYVSAGSIEYW 191

                         90       100       110
                 ....*....|....*....|....*....|.
gi 446584917 120 ADYENLIKKIYRMLKAGGN--LVFTVeHPVF 148
Cdd:PLN02490 192 PDPQRGIKEAYRVLKIGGKacLIGPV-HPTF 221
PRK14967 PRK14967
putative methyltransferase; Provisional
 43-112 4.81e-04

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 40.04  E-value: 4.81e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446584917  43 GKRVLDLGCGYGWHCIYAMENGASSVVGVDISHKMLEVAKGKThfpqieyeCCAIEDVD---------FPEESFDVILS 112
Cdd:PRK14967  37 GRRVLDLCTGSGALAVAAAAAGAGSVTAVDISRRAVRSARLNA--------LLAGVDVDvrrgdwaraVEFRPFDVVVS 107
PLN02396 PLN02396
hexaprenyldihydroxybenzoate methyltransferase
 41-153 4.85e-04

hexaprenyldihydroxybenzoate methyltransferase


Pssm-ID: 178018 [Multi-domain]  Cd Length: 322  Bit Score: 40.49  E-value: 4.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  41 FKGKRVLDLGCGYGWHCIYAMENGAsSVVGVDISHKMLEVAKGKTHF----PQIEYECCAIEDVDFPEESFDVILSSLAF 116
Cdd:PLN02396 130 FEGLKFIDIGCGGGLLSEPLARMGA-TVTGVDAVDKNVKIARLHADMdpvtSTIEYLCTTAEKLADEGRKFDAVLSLEVI 208

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446584917 117 HYVADYENLIKKIYRMLKAGGNLVFTVEHPVFTAHGT 153
Cdd:PLN02396 209 EHVANPAEFCKSLSALTIPNGATVLSTINRTMRAYAS 245
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
40-141 5.04e-04

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 40.54  E-value: 5.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  40 DFKGKRVLDLGCGYGwhcI---YAMENGASSVVGVDISHKMLEVAKgkthfpqieyECCAIEDVD----------FPEES 106
Cdd:COG2264  146 LKPGKTVLDVGCGSG---IlaiAAAKLGAKRVLAVDIDPVAVEAAR----------ENAELNGVEdrievvlgdlLEDGP 212

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 446584917 107 FDVILSslafhyvadyeN--------LIKKIYRMLKAGGNLVF 141
Cdd:COG2264  213 YDLVVA-----------NilanplieLAPDLAALLKPGGYLIL 244
PRK11036 PRK11036
tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;
31-139 6.33e-04

tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;


Pssm-ID: 182918  Cd Length: 255  Bit Score: 39.95  E-value: 6.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  31 WETLKKMLPDFKGK--RVLDLGCGYGWHCIYAMENGaSSVVGVDISHKMLEVAKGKTH----FPQIEYECCAIEDV-DFP 103
Cdd:PRK11036  31 WQDLDRLLAELPPRplRVLDAGGGEGQTAIKLAELG-HQVILCDLSAEMIQRAKQAAEakgvSDNMQFIHCAAQDIaQHL 109

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 446584917 104 EESFDVILsslaFH----YVADYENLIKKIYRMLKAGGNL 139
Cdd:PRK11036 110 ETPVDLIL----FHavleWVADPKSVLQTLWSVLRPGGAL 145
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 42-141 1.54e-03

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 38.24  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446584917  42 KGKRVLDLGCGYGWHCIY---AMENGAsSVVGVDISHKMLEVAkgKTHF------PQIEYECCAIEDV--DFPEESFDVI 110
Cdd:COG4122   16 GAKRILEIGTGTGYSTLWlarALPDDG-RLTTIEIDPERAAIA--RENFaraglaDRIRLILGDALEVlpRLADGPFDLV 92

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446584917 111 LsslafhyvAD-----YENLIKKIYRMLKAGGNLVF 141
Cdd:COG4122   93 F--------IDadksnYPDYLELALPLLRPGGLIVA 120
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 31-82 5.55e-03

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 37.33  E-value: 5.55e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446584917   31 WET-------LKKMLPDFKGKRVLDLGCGYGwhCI---YAMENGASSVVGVDISHKMLEVAK 82
Cdd:TIGR00536  96 PETeelvekaLASLISQPPILHILDLGTGSG--CIalaLAYEFPNAEVIAVDISPDALAVAE 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH