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Conserved domains on  [gi|446574693|ref|WP_000652039|]
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aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme [Staphylococcus aureus]

Protein Classification

aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme( domain architecture ID 10008287)

aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme is a PLP-dependent carbon-sulfur lyase that may be involved in methionine catabolism or in conferring resistance to aluminum

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YnbB COG4100
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion ...
 2-409 0e+00

Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism, General function prediction only];


:

Pssm-ID: 443276  Cd Length: 409  Bit Score: 751.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693   2 KDISKIVADVESTLAPYFKEIEETAYINQEKVLNAFHHVKATESDLQGSTGYGYDDFGRDHLEEIYAQAFKAEDAIVRPQ 81
Cdd:COG4100    1 EEILELVEEAEEELAPVFKEIDEIAEYNQLKVLKAFQKNRVSDSHFAGTTGYGYDDIGRDTLERVYADVFGAEDALVRPQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693  82 IISGTHAITIALQSLLKHGDELIYITGSPYDTLLEVIGVNGNGIESLMEHGVSYKDIALKE-GKIDIESVLDGISERTKV 160
Cdd:COG4100   81 IVSGTHAIALALFGVLRPGDELLSITGKPYDTLEEVIGIRGEGQGSLKEFGISYRQVPLTEdGKIDLEAIKKAINEKTKM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693 161 IAIQRSKGYDQRPSIPLDEIEQVITRLKNVHPNILIFVDNCYGEFVERREPIECGADLIAGSLIKNPGGGLAKIGGYIAG 240
Cdd:COG4100  161 VLIQRSRGYSWRPSLTIEEIGEIIKFVKSINPDVICFVDNCYGEFVETREPTEVGADLMAGSLIKNPGGGLAPTGGYIAG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693 241 RKDLIERCGYRLTAPGIGKEAGASLNALLEMYQGFFLAPHVVSQSLKGALFTSLFLEKMNMNTTPKYYEKRTDLIQTVKF 320
Cdd:COG4100  241 RKDLVELAAYRLTAPGIGKEVGATLGQNRLMYQGLFLAPHVVGEALKGAIFAAAVFEKLGFEVSPKPDEPRSDIIQAIKL 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693 321 KTKEQMISFCQSIQHASPINAHFSPEPSYMPGYEDDVIMAAGTFIQGSSIELSADGPIRPPYEAYVQGGLTYEHVKIAVT 400
Cdd:COG4100  321 GSPEKLIAFCQGIQKASPVDSHVTPEPWDMPGYEDPVIMAAGTFIQGSSIELSADGPIREPYIVYLQGGLTYEHVKLAIL 400


                 ....*....
gi 446574693 401 RAVKQLKEQ 409
Cdd:COG4100  401 SALQALLEK 409
 
Name Accession Description Interval E-value
YnbB COG4100
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion ...
 2-409 0e+00

Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 443276  Cd Length: 409  Bit Score: 751.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693   2 KDISKIVADVESTLAPYFKEIEETAYINQEKVLNAFHHVKATESDLQGSTGYGYDDFGRDHLEEIYAQAFKAEDAIVRPQ 81
Cdd:COG4100    1 EEILELVEEAEEELAPVFKEIDEIAEYNQLKVLKAFQKNRVSDSHFAGTTGYGYDDIGRDTLERVYADVFGAEDALVRPQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693  82 IISGTHAITIALQSLLKHGDELIYITGSPYDTLLEVIGVNGNGIESLMEHGVSYKDIALKE-GKIDIESVLDGISERTKV 160
Cdd:COG4100   81 IVSGTHAIALALFGVLRPGDELLSITGKPYDTLEEVIGIRGEGQGSLKEFGISYRQVPLTEdGKIDLEAIKKAINEKTKM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693 161 IAIQRSKGYDQRPSIPLDEIEQVITRLKNVHPNILIFVDNCYGEFVERREPIECGADLIAGSLIKNPGGGLAKIGGYIAG 240
Cdd:COG4100  161 VLIQRSRGYSWRPSLTIEEIGEIIKFVKSINPDVICFVDNCYGEFVETREPTEVGADLMAGSLIKNPGGGLAPTGGYIAG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693 241 RKDLIERCGYRLTAPGIGKEAGASLNALLEMYQGFFLAPHVVSQSLKGALFTSLFLEKMNMNTTPKYYEKRTDLIQTVKF 320
Cdd:COG4100  241 RKDLVELAAYRLTAPGIGKEVGATLGQNRLMYQGLFLAPHVVGEALKGAIFAAAVFEKLGFEVSPKPDEPRSDIIQAIKL 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693 321 KTKEQMISFCQSIQHASPINAHFSPEPSYMPGYEDDVIMAAGTFIQGSSIELSADGPIRPPYEAYVQGGLTYEHVKIAVT 400
Cdd:COG4100  321 GSPEKLIAFCQGIQKASPVDSHVTPEPWDMPGYEDPVIMAAGTFIQGSSIELSADGPIREPYIVYLQGGLTYEHVKLAIL 400


                 ....*....
gi 446574693 401 RAVKQLKEQ 409
Cdd:COG4100  401 SALQALLEK 409
Met_gamma_lyase pfam06838
Methionine gamma-lyase; This is a putative pyridoxal 5'-phosphate-dependent methionine ...
 4-407 0e+00

Methionine gamma-lyase; This is a putative pyridoxal 5'-phosphate-dependent methionine gamma-lyase enzyme involved in methionine catabolism.


Pssm-ID: 429146  Cd Length: 405  Bit Score: 689.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693    4 ISKIVADVESTLAPYFKEIEETAYINQEKVLNAFHHVKATESDLQGSTGYGYDDFGRDHLEEIYAQAFKAEDAIVRPQII 83
Cdd:pfam06838   1 VLKLYEQAENDILPIFKKIDEIVEFNQLKVLNAFQEERVSDHHFTGSTGYGYDDIGRDTLDRVYARVFGAEAALVRPQFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693   84 SGTHAITIALQSLLKHGDELIYITGSPYDTLLEVIGVNGNGIESLMEHGVSYKDIALKE-GKIDIESVLDGISERTKVIA 162
Cdd:pfam06838  81 SGTHAIATALFGVLRPGDELLYITGSPYDTLEEVIGIRGEGQGSLKDFGIGYREVPLLEdGKVDWEAIKTAITPKTKLIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693  163 IQRSKGYDQRPSIPLDEIEQVITRLKNVHPNILIFVDNCYGEFVERREPIECGADLIAGSLIKNPGGGLAKIGGYIAGRK 242
Cdd:pfam06838 161 IQRSKGYSWRPSLTIAEIKEIIKFVKEINPDVIVFVDNCYGEFVETKEPTHVGADLIAGSLIKNPGGGIAPTGGYIAGKA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693  243 DLIERCGYRLTAPGIGKEAGASLNALLEMYQGFFLAPHVVSQSLKGALFTSLFLEKMNMNTTPKYYEKRTDLIQTVKFKT 322
Cdd:pfam06838 241 DLVEQASYRLTAPGIGREGGATFGSLRLMYQGLFLAPHVVGEALKGAHLTARVLELLGFEVLPKYNEKRTDLIQAVKFGD 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693  323 KEQMISFCQSIQHASPINAHFSPEPSYMPGYEDDVIMAAGTFIQGSSIELSADGPIRPPYEAYVQGGLTYEHVKIAVTRA 402
Cdd:pfam06838 321 KEKLIAFCQAIQAASPIDSHVDPEPADMPGYEDDVIMAAGTFIQGSSIELSADGPIREPYIAYVQGGLTYEHVKIAVLIA 400


                  ....*
gi 446574693  403 VKQLK 407
Cdd:pfam06838 401 LDAIV 405
PRK06234 PRK06234
methionine gamma-lyase; Provisional
 84-245 3.49e-07

methionine gamma-lyase; Provisional


Pssm-ID: 168478 [Multi-domain]  Cd Length: 400  Bit Score: 52.14  E-value: 3.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693  84 SGTHAITIALQSLLKHGDELIyiTGspyDTLLEVIGvngngieSLMEHG-------VSYKDIAlkegkiDIESVLDGISE 156
Cdd:PRK06234  87 SGMGAISSSLWSALKAGDHVV--AS---DTLYGCTF-------ALLNHGltrygveVTFVDTS------NLEEVRNALKA 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693 157 RTKVIAIQRSKGydqrPSIPLDEIEQVITRLKNVHPNILIFVDNCYGE-FVERrePIECGADLIAGSLIKNPGGGLAKIG 235
Cdd:PRK06234 149 NTKVVYLETPAN----PTLKVTDIKAISNIAHENNKECLVFVDNTFCTpYIQR--PLQLGADVVVHSATKYLNGHGDVIA 222

                        170
                 ....*....|
gi 446574693 236 GYIAGRKDLI 245
Cdd:PRK06234 223 GFVVGKEEFI 232
CGS_like cd00614
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ...
 60-248 9.65e-06

CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.


Pssm-ID: 99738 [Multi-domain]  Cd Length: 369  Bit Score: 47.20  E-value: 9.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693  60 RDHLEEIYAQAFKAEDAIVRPqiiSGTHAITIALQSLLKHGDELI---YITGSPYDtLLEVIGVNGnGIEslmehgVSYK 136
Cdd:cd00614   42 VDALEKKLAALEGGEAALAFS---SGMAAISTVLLALLKAGDHVVasdDLYGGTYR-LFERLLPKL-GIE------VTFV 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693 137 DIAlkegkiDIESVLDGISERTKVIaiqrskgYDQRPSIPLDEIEQV--ITRLKNVHpNILIFVDNCYGEFVERRePIEC 214
Cdd:cd00614  111 DPD------DPEALEAAIKPETKLV-------YVESPTNPTLKVVDIeaIAELAHEH-GALLVVDNTFATPYLQR-PLEL 175

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 446574693 215 GADLIAGSLIKNPGGGLAKIGGYIAGR-KDLIERC 248
Cdd:cd00614  176 GADIVVHSATKYIGGHSDVIAGVVVGSgEALIQRL 210
 
Name Accession Description Interval E-value
YnbB COG4100
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion ...
 2-409 0e+00

Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 443276  Cd Length: 409  Bit Score: 751.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693   2 KDISKIVADVESTLAPYFKEIEETAYINQEKVLNAFHHVKATESDLQGSTGYGYDDFGRDHLEEIYAQAFKAEDAIVRPQ 81
Cdd:COG4100    1 EEILELVEEAEEELAPVFKEIDEIAEYNQLKVLKAFQKNRVSDSHFAGTTGYGYDDIGRDTLERVYADVFGAEDALVRPQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693  82 IISGTHAITIALQSLLKHGDELIYITGSPYDTLLEVIGVNGNGIESLMEHGVSYKDIALKE-GKIDIESVLDGISERTKV 160
Cdd:COG4100   81 IVSGTHAIALALFGVLRPGDELLSITGKPYDTLEEVIGIRGEGQGSLKEFGISYRQVPLTEdGKIDLEAIKKAINEKTKM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693 161 IAIQRSKGYDQRPSIPLDEIEQVITRLKNVHPNILIFVDNCYGEFVERREPIECGADLIAGSLIKNPGGGLAKIGGYIAG 240
Cdd:COG4100  161 VLIQRSRGYSWRPSLTIEEIGEIIKFVKSINPDVICFVDNCYGEFVETREPTEVGADLMAGSLIKNPGGGLAPTGGYIAG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693 241 RKDLIERCGYRLTAPGIGKEAGASLNALLEMYQGFFLAPHVVSQSLKGALFTSLFLEKMNMNTTPKYYEKRTDLIQTVKF 320
Cdd:COG4100  241 RKDLVELAAYRLTAPGIGKEVGATLGQNRLMYQGLFLAPHVVGEALKGAIFAAAVFEKLGFEVSPKPDEPRSDIIQAIKL 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693 321 KTKEQMISFCQSIQHASPINAHFSPEPSYMPGYEDDVIMAAGTFIQGSSIELSADGPIRPPYEAYVQGGLTYEHVKIAVT 400
Cdd:COG4100  321 GSPEKLIAFCQGIQKASPVDSHVTPEPWDMPGYEDPVIMAAGTFIQGSSIELSADGPIREPYIVYLQGGLTYEHVKLAIL 400


                 ....*....
gi 446574693 401 RAVKQLKEQ 409
Cdd:COG4100  401 SALQALLEK 409
Met_gamma_lyase pfam06838
Methionine gamma-lyase; This is a putative pyridoxal 5'-phosphate-dependent methionine ...
 4-407 0e+00

Methionine gamma-lyase; This is a putative pyridoxal 5'-phosphate-dependent methionine gamma-lyase enzyme involved in methionine catabolism.


Pssm-ID: 429146  Cd Length: 405  Bit Score: 689.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693    4 ISKIVADVESTLAPYFKEIEETAYINQEKVLNAFHHVKATESDLQGSTGYGYDDFGRDHLEEIYAQAFKAEDAIVRPQII 83
Cdd:pfam06838   1 VLKLYEQAENDILPIFKKIDEIVEFNQLKVLNAFQEERVSDHHFTGSTGYGYDDIGRDTLDRVYARVFGAEAALVRPQFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693   84 SGTHAITIALQSLLKHGDELIYITGSPYDTLLEVIGVNGNGIESLMEHGVSYKDIALKE-GKIDIESVLDGISERTKVIA 162
Cdd:pfam06838  81 SGTHAIATALFGVLRPGDELLYITGSPYDTLEEVIGIRGEGQGSLKDFGIGYREVPLLEdGKVDWEAIKTAITPKTKLIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693  163 IQRSKGYDQRPSIPLDEIEQVITRLKNVHPNILIFVDNCYGEFVERREPIECGADLIAGSLIKNPGGGLAKIGGYIAGRK 242
Cdd:pfam06838 161 IQRSKGYSWRPSLTIAEIKEIIKFVKEINPDVIVFVDNCYGEFVETKEPTHVGADLIAGSLIKNPGGGIAPTGGYIAGKA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693  243 DLIERCGYRLTAPGIGKEAGASLNALLEMYQGFFLAPHVVSQSLKGALFTSLFLEKMNMNTTPKYYEKRTDLIQTVKFKT 322
Cdd:pfam06838 241 DLVEQASYRLTAPGIGREGGATFGSLRLMYQGLFLAPHVVGEALKGAHLTARVLELLGFEVLPKYNEKRTDLIQAVKFGD 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693  323 KEQMISFCQSIQHASPINAHFSPEPSYMPGYEDDVIMAAGTFIQGSSIELSADGPIRPPYEAYVQGGLTYEHVKIAVTRA 402
Cdd:pfam06838 321 KEKLIAFCQAIQAASPIDSHVDPEPADMPGYEDDVIMAAGTFIQGSSIELSADGPIREPYIAYVQGGLTYEHVKIAVLIA 400


                  ....*
gi 446574693  403 VKQLK 407
Cdd:pfam06838 401 LDAIV 405
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
31-299 2.55e-07

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 52.31  E-value: 2.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693   31 EKVLNAFHHVKATESDLQGSTGYGYDDFGR---DHLEEIYAQAFKAEDAIvrpQIISGTHAITIALQSLLKHGDELIYI- 106
Cdd:pfam00155  17 PAVAKAEKDALAGGTRNLYGPTDGHPELREalaKFLGRSPVLKLDREAAV---VFGSGAGANIEALIFLLANPGDAILVp 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693  107 --TGSPYDTlleviGVNGNGIESlmehgVSYKDIALKEGKIDIESVLDGISERTKVIAIqrskGYDQRPS---IPLDEIE 181
Cdd:pfam00155  94 apTYASYIR-----IARLAGGEV-----VRYPLYDSNDFHLDFDALEAALKEKPKVVLH----TSPHNPTgtvATLEELE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693  182 QvITRLKNVHpNILIFVDNCYGEFV---ERREPIECGAD-----LIAGSLIKNpgGGLAKI-GGYIAGRKDLIErCGYRL 252
Cdd:pfam00155 160 K-LLDLAKEH-NILLLVDEAYAGFVfgsPDAVATRALLAegpnlLVVGSFSKA--FGLAGWrVGYILGNAAVIS-QLRKL 234

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 446574693  253 TAPGIGKEAGaslnallemyqgfflaPHVVSQSLKGALFTSLFLEKM 299
Cdd:pfam00155 235 ARPFYSSTHL----------------QAAAAAALSDPLLVASELEEM 265
PRK06234 PRK06234
methionine gamma-lyase; Provisional
 84-245 3.49e-07

methionine gamma-lyase; Provisional


Pssm-ID: 168478 [Multi-domain]  Cd Length: 400  Bit Score: 52.14  E-value: 3.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693  84 SGTHAITIALQSLLKHGDELIyiTGspyDTLLEVIGvngngieSLMEHG-------VSYKDIAlkegkiDIESVLDGISE 156
Cdd:PRK06234  87 SGMGAISSSLWSALKAGDHVV--AS---DTLYGCTF-------ALLNHGltrygveVTFVDTS------NLEEVRNALKA 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693 157 RTKVIAIQRSKGydqrPSIPLDEIEQVITRLKNVHPNILIFVDNCYGE-FVERrePIECGADLIAGSLIKNPGGGLAKIG 235
Cdd:PRK06234 149 NTKVVYLETPAN----PTLKVTDIKAISNIAHENNKECLVFVDNTFCTpYIQR--PLQLGADVVVHSATKYLNGHGDVIA 222

                        170
                 ....*....|
gi 446574693 236 GYIAGRKDLI 245
Cdd:PRK06234 223 GFVVGKEEFI 232
PRK07503 PRK07503
methionine gamma-lyase; Provisional
 84-247 4.12e-07

methionine gamma-lyase; Provisional


Pssm-ID: 181005 [Multi-domain]  Cd Length: 403  Bit Score: 51.73  E-value: 4.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693  84 SGTHAITIALQSLLKHGDELIY---ITGSPYdtllevigvngngieSLMEHGVSYKDIALKEGKI-DIESVLDGISERTK 159
Cdd:PRK07503  88 SGMGAITATLWTLLRPGDEVIVdqtLYGCTF---------------AFLHHGLGEFGVTVRHVDLtDPAALKAAISDKTR 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693 160 VIaiqrskgYDQRPSIP---LDEIEQViTRLKNVHpNILIFVDNCYGEFVERRePIECGADLIAGSLIKNPGGGLAKIGG 236
Cdd:PRK07503 153 MV-------YFETPANPnmrLVDIAAV-AEIAHGA-GAKVVVDNTYCTPYLQR-PLELGADLVVHSATKYLGGHGDITAG 222

                        170
                 ....*....|.
gi 446574693 237 YIAGRKDLIER 247
Cdd:PRK07503 223 LVVGGKALADR 233
CGS_like cd00614
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ...
 60-248 9.65e-06

CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.


Pssm-ID: 99738 [Multi-domain]  Cd Length: 369  Bit Score: 47.20  E-value: 9.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693  60 RDHLEEIYAQAFKAEDAIVRPqiiSGTHAITIALQSLLKHGDELI---YITGSPYDtLLEVIGVNGnGIEslmehgVSYK 136
Cdd:cd00614   42 VDALEKKLAALEGGEAALAFS---SGMAAISTVLLALLKAGDHVVasdDLYGGTYR-LFERLLPKL-GIE------VTFV 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693 137 DIAlkegkiDIESVLDGISERTKVIaiqrskgYDQRPSIPLDEIEQV--ITRLKNVHpNILIFVDNCYGEFVERRePIEC 214
Cdd:cd00614  111 DPD------DPEALEAAIKPETKLV-------YVESPTNPTLKVVDIeaIAELAHEH-GALLVVDNTFATPYLQR-PLEL 175

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 446574693 215 GADLIAGSLIKNPGGGLAKIGGYIAGR-KDLIERC 248
Cdd:cd00614  176 GADIVVHSATKYIGGHSDVIAGVVVGSgEALIQRL 210
AAT_like cd00609
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 41-315 2.97e-05

Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.


Pssm-ID: 99734 [Multi-domain]  Cd Length: 350  Bit Score: 45.80  E-value: 2.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693  41 KATESDLQGSTGYgYDDFGRDHLEEIYAQAFKAEDAIVRP--QII---SGTHAITIALQSLLKHGDELIYITGS--PYDT 113
Cdd:cd00609   20 LAAAALRAGLLGY-YPDPGLPELREAIAEWLGRRGGVDVPpeEIVvtnGAQEALSLLLRALLNPGDEVLVPDPTypGYEA 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693 114 LLEVIGVNGNGIESLmEHGVSYKDIALKEGKIDiesvldgisERTKVIAIQrskgYDQRPS---IPLDEIEQVITRLKNv 190
Cdd:cd00609   99 AARLAGAEVVPVPLD-EEGGFLLDLELLEAAKT---------PKTKLLYLN----NPNNPTgavLSEEELEELAELAKK- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693 191 hPNILIFVDNCYGEFVERREPIecgadLIAGSLIKNPG----GGLAKIGGyIAGrkdliERCGYrLTAPgigkeAGASLN 266
Cdd:cd00609  164 -HGILIISDEAYAELVYDGEPP-----PALALLDAYERvivlRSFSKTFG-LPG-----LRIGY-LIAP-----PEELLE 225

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446574693 267 ALLEMYQGFFLAPHVVSQSLKGALFTSL--FLEKMNmnttpKYYEKRTDLI 315
Cdd:cd00609  226 RLKKLLPYTTSGPSTLSQAAAAAALDDGeeHLEELR-----ERYRRRRDAL 271
PRK08247 PRK08247
methionine biosynthesis PLP-dependent protein;
50-256 7.72e-05

methionine biosynthesis PLP-dependent protein;


Pssm-ID: 181320 [Multi-domain]  Cd Length: 366  Bit Score: 44.31  E-value: 7.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693  50 STGYGYDDFG---RDHLEEIYAQAFKAEDAIVrpqIISGTHAITIALqSLLKHGDELIY---ITGSPYdTLLEvigvngn 123
Cdd:PRK08247  41 STGFDYSRTGnptRGVLEQAIADLEGGDQGFA---CSSGMAAIQLVM-SLFRSGDELIVssdLYGGTY-RLFE------- 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693 124 giESLMEHGVS--YKDIAlkegkiDIESVLDGISERTKVIAIQRskgydqrPSIPLDEIEQV--ITRLKNVHpNILIFVD 199
Cdd:PRK08247 109 --EHWKKWNVRfvYVNTA------SLKAIEQAITPNTKAIFIET-------PTNPLMQETDIaaIAKIAKKH-GLLLIVD 172

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446574693 200 NCYGEFVERRePIECGADLIAGSLIKNPGGGLAKIGGYI-AGRKDLIERCGYRLTAPG 256
Cdd:PRK08247 173 NTFYTPVLQR-PLEEGADIVIHSATKYLGGHNDVLAGLVvAKGQELCERLAYYQNAAG 229
PRK08574 PRK08574
cystathionine gamma-synthase family protein;
63-245 1.98e-04

cystathionine gamma-synthase family protein;


Pssm-ID: 236298 [Multi-domain]  Cd Length: 385  Bit Score: 43.13  E-value: 1.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693  63 LEEIYAQAFKAEDAIVrpqIISGTHAITIALQSLLKHGDElIYITGSPYDTLLEVIgvngngiESLMEHGVSykdiaLKE 142
Cdd:PRK08574  58 LEEALAKLEGGVDALA---FNSGMAAISTLFFSLLKAGDR-VVLPMEAYGTTLRLL-------KSLEKFGVK-----VVL 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693 143 GKIDIESVLDGISE-RTKVIAIQRSKGydqrPSIPLDEIEQVITRLKNVhpNILIFVDNCYGEFVERRePIECGADLIAG 221
Cdd:PRK08574 122 AYPSTEDIIEAIKEgRTKLVFIETMTN----PTLKVIDVPEVAKAAKEL--GAILVVDNTFATPLLYR-PLRHGADFVVH 194

                        170       180
                 ....*....|....*....|....
gi 446574693 222 SLIKnpggglakiggYIAGRKDLI 245
Cdd:PRK08574 195 SLTK-----------YIAGHNDVV 207
Aminotran_5 pfam00266
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ...
 84-247 1.95e-03

Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.


Pssm-ID: 425567 [Multi-domain]  Cd Length: 368  Bit Score: 39.92  E-value: 1.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693   84 SGTHAITIALQSL---LKHGDELIYitgspydtllevigvngngieSLMEH--------------GVSYKDIAL-KEGKI 145
Cdd:pfam00266  69 GTTEAINLVALSLgrsLKPGDEIVI---------------------TEMEHhanlvpwqelakrtGARVRVLPLdEDGLL 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693  146 DIESVLDGISERTKVIAIQ---RSKGYdqrpsipLDEIEQVITRLKNVhpNILIFVDNCYGeFVERrePI---ECGADLI 219
Cdd:pfam00266 128 DLDELEKLITPKTKLVAIThvsNVTGT-------IQPVPEIGKLAHQY--GALVLVDAAQA-IGHR--PIdvqKLGVDFL 195

                         170       180
                  ....*....|....*....|....*....
gi 446574693  220 AGSLIKNPG-GGLakigGYIAGRKDLIER 247
Cdd:pfam00266 196 AFSGHKLYGpTGI----GVLYGRRDLLEK 220
PRK06084 PRK06084
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
74-238 2.85e-03

bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;


Pssm-ID: 180392 [Multi-domain]  Cd Length: 425  Bit Score: 39.50  E-value: 2.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693  74 EDAIVRPQIISGTHAITIALQSLLKHGDELIYIT---GSPYDTLLEVIgvNGNGIESLMehgVSYKDIALKEGKIDiesv 150
Cdd:PRK06084  71 EGGVGALAVASGMAAITYAIQTIAEAGDNIVSVAklyGGTYNLLAHTL--PRIGIETRF---AAHDDIAALEALID---- 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446574693 151 ldgisERTKVIAIQrSKGYDQRPSIPLDEIEQVITRlknvHPNILIfVDNCYGEFVERRePIECGADLIAGSLIKNPGGG 230
Cdd:PRK06084 142 -----ERTKAVFCE-SIGNPAGNIIDIQALADAAHR----HGVPLI-VDNTVATPVLCR-PFEHGADIVVHSLTKYIGGH 209


                 ....*...
gi 446574693 231 LAKIGGYI 238
Cdd:PRK06084 210 GTSIGGIV 217
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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