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Conserved domains on  [gi|446571271|ref|WP_000648617|]
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MULTISPECIES: uridine kinase [Staphylococcus]

Protein Classification

uridine-cytidine kinase( domain architecture ID 10792545)

uridine kinase, or uridine cytidine kinase, catalyzes the ATP-dependent phosphorylation of uridine or cytidine to yield UMP or CMP

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PRK05480 PRK05480
uridine/cytidine kinase; Provisional
17-206 1.45e-125

uridine/cytidine kinase; Provisional


:

Pssm-ID: 235492 [Multi-domain]  Cd Length: 209  Bit Score: 352.92  E-value: 1.45e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  17 KTTVTNEIMKNLEGHSVALLAQDYYYKDQKHLTFDERLETNYDHPFAFDNDLLIENLKDLKNGKAVEVPTYDYASHTRSD 96
Cdd:PRK05480  19 KTTVASTIYEELGDESIAVIPQDSYYKDQSHLSFEERVKTNYDHPDAFDHDLLIEHLKALKAGKAIEIPVYDYTEHTRSK 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  97 ITIDFKPKDVIIVEGIFALENKVLRDMMDVKIYVDTDADLRILRRLTRDTKERGRSMDSVINQYLSVVRPMHDQFIEPTK 176
Cdd:PRK05480  99 ETIRVEPKDVIILEGILLLEDERLRDLMDIKIFVDTPLDIRLIRRLKRDVNERGRSLESVINQYLSTVRPMHLQFIEPSK 178
                        170       180       190
                 ....*....|....*....|....*....|
gi 446571271 177 KYADIIIPEGGSNKVAIDIMTTKIQSLVSK 206
Cdd:PRK05480 179 RYADIIIPEGGKNRVAIDILKAKIRQLLEK 208
 
Name Accession Description Interval E-value
PRK05480 PRK05480
uridine/cytidine kinase; Provisional
17-206 1.45e-125

uridine/cytidine kinase; Provisional


Pssm-ID: 235492 [Multi-domain]  Cd Length: 209  Bit Score: 352.92  E-value: 1.45e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  17 KTTVTNEIMKNLEGHSVALLAQDYYYKDQKHLTFDERLETNYDHPFAFDNDLLIENLKDLKNGKAVEVPTYDYASHTRSD 96
Cdd:PRK05480  19 KTTVASTIYEELGDESIAVIPQDSYYKDQSHLSFEERVKTNYDHPDAFDHDLLIEHLKALKAGKAIEIPVYDYTEHTRSK 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  97 ITIDFKPKDVIIVEGIFALENKVLRDMMDVKIYVDTDADLRILRRLTRDTKERGRSMDSVINQYLSVVRPMHDQFIEPTK 176
Cdd:PRK05480  99 ETIRVEPKDVIILEGILLLEDERLRDLMDIKIFVDTPLDIRLIRRLKRDVNERGRSLESVINQYLSTVRPMHLQFIEPSK 178
                        170       180       190
                 ....*....|....*....|....*....|
gi 446571271 177 KYADIIIPEGGSNKVAIDIMTTKIQSLVSK 206
Cdd:PRK05480 179 RYADIIIPEGGKNRVAIDILKAKIRQLLEK 208
UMPK cd02023
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or ...
13-203 2.01e-101

Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine.


Pssm-ID: 238981 [Multi-domain]  Cd Length: 198  Bit Score: 291.38  E-value: 2.01e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  13 SGSGKTTVTNEIMKNLEGHSVALLAQDYYYKDQKHLTFDERLETNYDHPFAFDNDLLIENLKDLKNGKAVEVPTYDYASH 92
Cdd:cd02023    8 SGSGKTTVAEEIIEQLGNPKVVIISQDSYYKDLSHEELEERKNNNYDHPDAFDFDLLISHLQDLKNGKSVEIPVYDFKTH 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  93 TRSDITIDFKPKDVIIVEGIFALENKVLRDMMDVKIYVDTDADLRILRRLTRDTKERGRSMDSVINQYLSVVRPMHDQFI 172
Cdd:cd02023   88 SRLKETVTVYPADVIILEGILALYDKELRDLMDLKIFVDTDADVRLIRRIERDIVERGRDLESVINQYLKFVKPMHEQFI 167
                        170       180       190
                 ....*....|....*....|....*....|.
gi 446571271 173 EPTKKYADIIIPEGGSNKVAIDIMTTKIQSL 203
Cdd:cd02023  168 EPTKRYADVIIPRGGDNHVAIDLIVQHIKSK 198
udk TIGR00235
uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in ...
17-203 3.11e-90

uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in phosphoribulokinase hits at scores of 160 and below [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 272977  Cd Length: 207  Bit Score: 263.48  E-value: 3.11e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271   17 KTTVTNEIMKNLEGHSVALLAQDYYYKDQKHLTFDERLETNYDHPFAFDNDLLIENLKDLKNGKAVEVPTYDYASHTRSD 96
Cdd:TIGR00235  19 KTTVARKIYEQLGKLEIVIISQDNYYKDQSHLEMAERKKTNFDHPDAFDNDLLYEHLKNLKNGSPIDVPVYDYVNHTRPK 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271   97 ITIDFKPKDVIIVEGIFALENKVLRDMMDVKIYVDTDADLRILRRLTRDTKERGRSMDSVINQYLSVVRPMHDQFIEPTK 176
Cdd:TIGR00235  99 ETVHIEPKDVVILEGIMPLFDERLRDLMDLKIFVDTPLDIRLIRRIERDINERGRSLDSVIDQYRKTVRPMYEQFVEPTK 178
                         170       180
                  ....*....|....*....|....*..
gi 446571271  177 KYADIIIPEGGSNKVAIDIMTTKIQSL 203
Cdd:TIGR00235 179 QYADLIIPEGGRNEVAINVLDTKIKHL 205
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
15-202 3.79e-90

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 263.24  E-value: 3.79e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  15 SGKTTVTNEIMKNLEGHSVALLAQDYYYKDQKHLTFDERLETNYDHPFAFDNDLLIENLKDLKNGKAVEVPTYDYASHTR 94
Cdd:COG0572   18 SGKTTFARRLAEQLGADKVVVISLDDYYKDREHLPLDERGKPNFDHPEAFDLDLLNEHLEPLKAGESVELPVYDFATGTR 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  95 SDITIDFKPKDVIIVEGIFALENKVLRDMMDVKIYVDTDADLRILRRLTRDTKERGRSMDSVINQYLSVVRPMHDQFIEP 174
Cdd:COG0572   98 SGETVKVEPADVIIVEGIHALNDELLRDLLDLKIYVDADTDVRLIRRIVRDGEERGRTAESVIEQYWATVRPGHEQYIEP 177
                        170       180
                 ....*....|....*....|....*....
gi 446571271 175 TKKYADIIIPEGGS-NKVAIDIMTTKIQS 202
Cdd:COG0572  178 TKEYADIVIPNGGPlNPVALDLLVARLLS 206
PRK pfam00485
Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop ...
17-192 6.47e-39

Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop containing kinases: phosphoribulokinases, uridine kinases and bacterial pantothenate kinases(CoaA). Arabidopsis and other organizms have a dual uridine kinase/uracil phosphoribosyltransferase protein where the N-terminal region consists of a UK domain and the C-terminal region of a UPRT domain.


Pssm-ID: 425711 [Multi-domain]  Cd Length: 196  Bit Score: 132.52  E-value: 6.47e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271   17 KTTVTNEI--------MKNLEGHSVALLAQDYYYKDQKHLTFDERLETNYDH--PFAFDNDLLIENLKDLKNGKAVEVPT 86
Cdd:pfam00485  12 KTTVARRIvsifgregVPAVGIEGDSFHSTDRFYMDLHPEDRKRAGNNGYSFdgPEANDFDLLYEQFKELKEGGSVDKPI 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271   87 YDYASHTRSDITIDFKPKDVIIVEGIFALENKVLRDMMDVKIYVDTDADLRILRRLTRDTKERGRSMDSVINQYLSvVRP 166
Cdd:pfam00485  92 YNHVTHERDPTPELIEGADVLVIEGLHALYDERVAQLLDLKIYVDPDIDLELARKIQRDMAERGHSLEGVTDSILF-RKP 170
                         170       180
                  ....*....|....*....|....*.
gi 446571271  167 MHDQFIEPTKKYADIIIPEGGSNKVA 192
Cdd:pfam00485 171 DYVNYIDPQFSYADLIIQRVPTNDTA 196
 
Name Accession Description Interval E-value
PRK05480 PRK05480
uridine/cytidine kinase; Provisional
17-206 1.45e-125

uridine/cytidine kinase; Provisional


Pssm-ID: 235492 [Multi-domain]  Cd Length: 209  Bit Score: 352.92  E-value: 1.45e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  17 KTTVTNEIMKNLEGHSVALLAQDYYYKDQKHLTFDERLETNYDHPFAFDNDLLIENLKDLKNGKAVEVPTYDYASHTRSD 96
Cdd:PRK05480  19 KTTVASTIYEELGDESIAVIPQDSYYKDQSHLSFEERVKTNYDHPDAFDHDLLIEHLKALKAGKAIEIPVYDYTEHTRSK 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  97 ITIDFKPKDVIIVEGIFALENKVLRDMMDVKIYVDTDADLRILRRLTRDTKERGRSMDSVINQYLSVVRPMHDQFIEPTK 176
Cdd:PRK05480  99 ETIRVEPKDVIILEGILLLEDERLRDLMDIKIFVDTPLDIRLIRRLKRDVNERGRSLESVINQYLSTVRPMHLQFIEPSK 178
                        170       180       190
                 ....*....|....*....|....*....|
gi 446571271 177 KYADIIIPEGGSNKVAIDIMTTKIQSLVSK 206
Cdd:PRK05480 179 RYADIIIPEGGKNRVAIDILKAKIRQLLEK 208
UMPK cd02023
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or ...
13-203 2.01e-101

Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine.


Pssm-ID: 238981 [Multi-domain]  Cd Length: 198  Bit Score: 291.38  E-value: 2.01e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  13 SGSGKTTVTNEIMKNLEGHSVALLAQDYYYKDQKHLTFDERLETNYDHPFAFDNDLLIENLKDLKNGKAVEVPTYDYASH 92
Cdd:cd02023    8 SGSGKTTVAEEIIEQLGNPKVVIISQDSYYKDLSHEELEERKNNNYDHPDAFDFDLLISHLQDLKNGKSVEIPVYDFKTH 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  93 TRSDITIDFKPKDVIIVEGIFALENKVLRDMMDVKIYVDTDADLRILRRLTRDTKERGRSMDSVINQYLSVVRPMHDQFI 172
Cdd:cd02023   88 SRLKETVTVYPADVIILEGILALYDKELRDLMDLKIFVDTDADVRLIRRIERDIVERGRDLESVINQYLKFVKPMHEQFI 167
                        170       180       190
                 ....*....|....*....|....*....|.
gi 446571271 173 EPTKKYADIIIPEGGSNKVAIDIMTTKIQSL 203
Cdd:cd02023  168 EPTKRYADVIIPRGGDNHVAIDLIVQHIKSK 198
udk TIGR00235
uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in ...
17-203 3.11e-90

uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in phosphoribulokinase hits at scores of 160 and below [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 272977  Cd Length: 207  Bit Score: 263.48  E-value: 3.11e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271   17 KTTVTNEIMKNLEGHSVALLAQDYYYKDQKHLTFDERLETNYDHPFAFDNDLLIENLKDLKNGKAVEVPTYDYASHTRSD 96
Cdd:TIGR00235  19 KTTVARKIYEQLGKLEIVIISQDNYYKDQSHLEMAERKKTNFDHPDAFDNDLLYEHLKNLKNGSPIDVPVYDYVNHTRPK 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271   97 ITIDFKPKDVIIVEGIFALENKVLRDMMDVKIYVDTDADLRILRRLTRDTKERGRSMDSVINQYLSVVRPMHDQFIEPTK 176
Cdd:TIGR00235  99 ETVHIEPKDVVILEGIMPLFDERLRDLMDLKIFVDTPLDIRLIRRIERDINERGRSLDSVIDQYRKTVRPMYEQFVEPTK 178
                         170       180
                  ....*....|....*....|....*..
gi 446571271  177 KYADIIIPEGGSNKVAIDIMTTKIQSL 203
Cdd:TIGR00235 179 QYADLIIPEGGRNEVAINVLDTKIKHL 205
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
15-202 3.79e-90

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 263.24  E-value: 3.79e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  15 SGKTTVTNEIMKNLEGHSVALLAQDYYYKDQKHLTFDERLETNYDHPFAFDNDLLIENLKDLKNGKAVEVPTYDYASHTR 94
Cdd:COG0572   18 SGKTTFARRLAEQLGADKVVVISLDDYYKDREHLPLDERGKPNFDHPEAFDLDLLNEHLEPLKAGESVELPVYDFATGTR 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  95 SDITIDFKPKDVIIVEGIFALENKVLRDMMDVKIYVDTDADLRILRRLTRDTKERGRSMDSVINQYLSVVRPMHDQFIEP 174
Cdd:COG0572   98 SGETVKVEPADVIIVEGIHALNDELLRDLLDLKIYVDADTDVRLIRRIVRDGEERGRTAESVIEQYWATVRPGHEQYIEP 177
                        170       180
                 ....*....|....*....|....*....
gi 446571271 175 TKKYADIIIPEGGS-NKVAIDIMTTKIQS 202
Cdd:COG0572  178 TKEYADIVIPNGGPlNPVALDLLVARLLS 206
PTZ00301 PTZ00301
uridine kinase; Provisional
17-199 3.74e-56

uridine kinase; Provisional


Pssm-ID: 140322 [Multi-domain]  Cd Length: 210  Bit Score: 177.12  E-value: 3.74e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  17 KTTVTNEIMKNLEGHSVALLAQDYYYKDQKHLTFDERLETNYDHPFAFDNDLLIENLKDLKNGKAVEVPTYDYASHTRSD 96
Cdd:PTZ00301  20 STNIVSELMAHCGPVSIGVICEDFYYRDQSNIPESERAYTNYDHPKSLEHDLLTTHLRELKSGKTVQIPQYDYVHHTRSD 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  97 ITIDFKPKDVIIVEGIFALENKVLRDMMDVKIYVDTDADLRILRRLTRDTKERGRSMDSVINQYLSVVRPMHDQFIEPTK 176
Cdd:PTZ00301 100 TAVTMTPKSVLIVEGILLFTNAELRNEMDCLIFVDTPLDICLIRRAKRDMRERGRTFESVIEQYEATVRPMYYAYVEPSK 179
                        170       180
                 ....*....|....*....|...
gi 446571271 177 KYADIIIPEGGSNKVAIDIMTTK 199
Cdd:PTZ00301 180 VYADIIVPSWKDNSVAVGVLRAK 202
PRK pfam00485
Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop ...
17-192 6.47e-39

Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop containing kinases: phosphoribulokinases, uridine kinases and bacterial pantothenate kinases(CoaA). Arabidopsis and other organizms have a dual uridine kinase/uracil phosphoribosyltransferase protein where the N-terminal region consists of a UK domain and the C-terminal region of a UPRT domain.


Pssm-ID: 425711 [Multi-domain]  Cd Length: 196  Bit Score: 132.52  E-value: 6.47e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271   17 KTTVTNEI--------MKNLEGHSVALLAQDYYYKDQKHLTFDERLETNYDH--PFAFDNDLLIENLKDLKNGKAVEVPT 86
Cdd:pfam00485  12 KTTVARRIvsifgregVPAVGIEGDSFHSTDRFYMDLHPEDRKRAGNNGYSFdgPEANDFDLLYEQFKELKEGGSVDKPI 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271   87 YDYASHTRSDITIDFKPKDVIIVEGIFALENKVLRDMMDVKIYVDTDADLRILRRLTRDTKERGRSMDSVINQYLSvVRP 166
Cdd:pfam00485  92 YNHVTHERDPTPELIEGADVLVIEGLHALYDERVAQLLDLKIYVDPDIDLELARKIQRDMAERGHSLEGVTDSILF-RKP 170
                         170       180
                  ....*....|....*....|....*.
gi 446571271  167 MHDQFIEPTKKYADIIIPEGGSNKVA 192
Cdd:pfam00485 171 DYVNYIDPQFSYADLIIQRVPTNDTA 196
PRK cd02026
Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or ...
17-183 5.93e-25

Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH produced by the primary reactions of photosynthesis.


Pssm-ID: 238984 [Multi-domain]  Cd Length: 273  Bit Score: 98.18  E-value: 5.93e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  17 KTTVTNEIMKNLEGHSVALLAQDYYYK-DQKhltfdERLETNYD--HPFAFDNDLLIENLKDLKNGKAVEVPTYDYASHT 93
Cdd:cd02026   12 KSTFLRRLTSLFGSDLVTVICLDDYHSlDRK-----GRKETGITalDPRANNFDLMYEQLKALKEGQAIEKPIYNHVTGL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  94 rsditID----FKPKDVIIVEGIFALENKVLRDMMDVKIYVDTDADLRILRRLTRDTKERGRSMDSVINQYLSvVRPMHD 169
Cdd:cd02026   87 -----IDppelIKPTKIVVIEGLHPLYDERVRELLDFSVYLDISDEVKFAWKIQRDMAERGHSLEDVLASIEA-RKPDFE 160
                        170
                 ....*....|....
gi 446571271 170 QFIEPTKKYADIII 183
Cdd:cd02026  161 AYIDPQKQYADVVI 174
PRK07429 PRK07429
phosphoribulokinase; Provisional
17-183 9.42e-25

phosphoribulokinase; Provisional


Pssm-ID: 180975  Cd Length: 327  Bit Score: 98.54  E-value: 9.42e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  17 KTTVTNEIMKNLEGHSVALLAQDYYYK-DQKhltfdERLETNYD--HPFAFDNDLLIENLKDLKNGKAVEVPTYDYASHT 93
Cdd:PRK07429  21 KTTFLRGLADLLGEELVTVICTDDYHSyDRK-----QRKELGITalDPRANNLDIMYEHLKALKTGQPILKPIYNHETGT 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  94 rsditID----FKPKDVIIVEGIFALENKVLRDMMDVKIYVDTDADLRILRRLTRDTKERGRSMDSVINQYLSvVRPMHD 169
Cdd:PRK07429  96 -----FDppeyIEPNKIVVVEGLHPLYDERVRELYDFKVYLDPPEEVKIAWKIKRDMAKRGHTYEQVLAEIEA-REPDFE 169
                        170
                 ....*....|....
gi 446571271 170 QFIEPTKKYADIII 183
Cdd:PRK07429 170 AYIRPQRQWADVVI 183
UMPK_like cd02028
Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the ...
17-183 1.28e-24

Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK).


Pssm-ID: 238986 [Multi-domain]  Cd Length: 179  Bit Score: 95.06  E-value: 1.28e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  17 KTTVTNEIMKNLE--GHSVALLAQDYYYKDQKHltfDERLETNYDHPFAFDNDLLIENLKDLKNGKAVEVPTYDYASHTR 94
Cdd:cd02028   12 KTTFAKKLSNQLRvnGIGPVVISLDDYYVPRKT---PRDEDGNYDFESILDLDLLNKNLHDLLNGKEVELPIYDFRTGKR 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  95 -SDITIDFKPKDVIIVEGIFALENKvLRDMMDVKIYVDT-DADLRILRRLTRDTKERGRSMDSVINQYlSVVRPMHDQFI 172
Cdd:cd02028   89 rGYRKLKLPPSGVVILEGIYALNER-LRSLLDIRVAVSGgVHLNRLLRRVVRDIQFRGYSAELTILMW-PSVPSGEEFII 166
                        170
                 ....*....|.
gi 446571271 173 EPTKKYADIII 183
Cdd:cd02028  167 PPLQEAAIVMF 177
PLN02318 PLN02318
phosphoribulokinase/uridine kinase
17-183 6.35e-23

phosphoribulokinase/uridine kinase


Pssm-ID: 177952 [Multi-domain]  Cd Length: 656  Bit Score: 95.70  E-value: 6.35e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  17 KTTVTNEIMKNLEGhsVALLAQDYYyKDQKHLtfderLETNYDHPFAFDNDLLIENLKDLKNGKAVEVPTYDYASHTRSD 96
Cdd:PLN02318  78 KTVFTEKVLNFMPS--IAVISMDNY-NDSSRI-----IDGNFDDPRLTDYDTLLDNIHDLKAGKSVQVPIYDFKSSSRVG 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  97 I-TIDFKPKDVIIVEGIFALENKvLRDMMDVKIYVDTDADLRILRRLTRDTKERGRSMDSVINQYLSVVRPMHDQFIEPT 175
Cdd:PLN02318 150 YrTLEVPSSRIVIIEGIYALSEK-LRPLLDLRVSVTGGVHFDLVKRVLRDIQRAGQEPEEIIHQISETVYPMYKAFIEPD 228

                 ....*...
gi 446571271 176 KKYADIII 183
Cdd:PLN02318 229 LQTAHIKI 236
PLN02348 PLN02348
phosphoribulokinase
60-183 3.39e-22

phosphoribulokinase


Pssm-ID: 215198  Cd Length: 395  Bit Score: 92.60  E-value: 3.39e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  60 HPFAFDNDLLIENLKDLKNGKAVEVPTYDYASHTRsDITIDFKPKDVIIVEGIFALENKVLRDMMDVKIYVDTDADLRIL 139
Cdd:PLN02348 120 DPRANNFDLMYEQVKALKEGKAVEKPIYNHVTGLL-DPPELIEPPKILVIEGLHPMYDERVRDLLDFSIYLDISDDVKFA 198
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 446571271 140 RRLTRDTKERGRSMDSvINQYLSVVRPMHDQFIEPTKKYADIII 183
Cdd:PLN02348 199 WKIQRDMAERGHSLES-IKASIEARKPDFDAYIDPQKQYADVVI 241
PRK07667 PRK07667
uridine kinase; Provisional
17-183 2.23e-09

uridine kinase; Provisional


Pssm-ID: 169051  Cd Length: 193  Bit Score: 54.74  E-value: 2.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  17 KTTVTNEIMKNL--EGHSVALLAQDYYYKDQK---HLTFDERLETNYdhpFAFDNDLLIENL-KDLKNGKAVEVPTYDYA 90
Cdd:PRK07667  30 KTTFVANLKENMkqEGIPFHIFHIDDYIVERNkryHTGFEEWYEYYY---LQWDIEWLRQKFfRKLQNETKLTLPFYHDE 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  91 SHTRSDITIDFKPKDVIIVEGIFaLENKVLRDMMDVKIYVDTDADLRILRRLtRDTKERgrsMDSVINQYLsvvrPMHDQ 170
Cdd:PRK07667 107 TDTCEMKKVQIPIVGVIVIEGVF-LQRKEWRDFFHYMVYLDCPRETRFLRES-EETQKN---LSKFKNRYW----KAEDY 177
                        170
                 ....*....|....*
gi 446571271 171 FIEPT--KKYADIII 183
Cdd:PRK07667 178 YLETEspKDRADLVI 192
PRK08233 PRK08233
hypothetical protein; Provisional
98-183 3.46e-08

hypothetical protein; Provisional


Pssm-ID: 181310 [Multi-domain]  Cd Length: 182  Bit Score: 51.28  E-value: 3.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  98 TIDFKPKDVIIVEGIFALENKVLRDMMDVKIYVDTDADLRILRRLTRDTKErgRSMDSVIN---QYLSVVRPMHDQFIEP 174
Cdd:PRK08233  72 LIAKSNVDYIIVDYPFAYLNSEMRQFIDVTIFIDTPLDIAMARRILRDFKE--DTGNEIHNdlkHYLNYARPLYLEALHT 149

                 ....*....
gi 446571271 175 TKKYADIII 183
Cdd:PRK08233 150 VKPNADIVL 158
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
15-145 5.85e-06

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 45.01  E-value: 5.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  15 SGKTTVTNEIMKNLEghSVALLAQDYYYKDQKHLTFDERLETNYDHPFAFDNDLLIENL-----------KDLKNGKAVE 83
Cdd:cd02024   10 SGKTTLAKLLQRILP--NCCVIHQDDFFKPEDEIPVDENGFKQWDVLEALDMEAMMSTLdywretghfpkFLRSHGNEND 87
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446571271  84 VPT---YDYASHTRSDITIDFKPKDVIIVEGIFALENKVLRDMMDVKIYVDTDADLRILRRLTRD 145
Cdd:cd02024   88 PEKefiEDAQIEETKADLLGAEDLHILIVDGFLLYNYKPLVDLFDIRYFLRVPYETCKRRREART 152
CoaA COG1072
Panthothenate kinase [Coenzyme transport and metabolism]; Panthothenate kinase is part of the ...
13-191 5.58e-05

Panthothenate kinase [Coenzyme transport and metabolism]; Panthothenate kinase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 440690  Cd Length: 309  Bit Score: 42.97  E-value: 5.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  13 SGSGKTTvTNEIMKnleghsvALLAQDYYYKDQKHLTFD---------ERL---------ETnydhpfaFDNDLLIENLK 74
Cdd:COG1072   95 VAVGKST-TARLLQ-------ALLSRWPEHPKVELVTTDgflypnavlERRglmdrkgfpES-------YDRRGLLRFLA 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  75 DLKNGKA-VEVPTYdyaSHTRSDI------TIDfKPkDVIIVEGI-----FALENKVLRDMMDVKIYVDTDADLrILRRL 142
Cdd:COG1072  160 RVKSGDPeVRAPVY---SHLLYDIvpgaivVVD-QP-DILIVEGNnvlqdEPNPWLFVSDFFDFSIYVDADEED-LREWY 233
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446571271 143 T------RDTKER----------GRSMDSVINQYLSVVR----PMHDQFIEPTKKYADIIIPEGGSNKV 191
Cdd:COG1072  234 VerflklRETAFRdpdsyfhryaGLSEEEARAWAEEIWReinlPNLAENILPTRSRADLILRKGADHSV 302
PRK06696 PRK06696
uridine kinase; Validated
87-183 2.06e-04

uridine kinase; Validated


Pssm-ID: 180660  Cd Length: 223  Bit Score: 40.73  E-value: 2.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446571271  87 YDYASHT-RSDITIDFKPKD-----VIIVEGIFALEnKVLRDMMDVKIYVDTDADLRILRRLTRDTKERGrSMDSVINQY 160
Cdd:PRK06696 105 YRTASHDlKTDIPVHNPPLLaapnaVLIVDGTFLLR-PELRDLWDYKIFLDTDFEVSRRRGAKRDTEAFG-SYEEAEKMY 182
                         90       100
                 ....*....|....*....|....*.
gi 446571271 161 LSVVRPMHDQFIE---PtKKYADIII 183
Cdd:PRK06696 183 LARYHPAQKLYIAeanP-KERADVVI 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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