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Conserved domains on  [gi|446550739|ref|WP_000628085|]
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MULTISPECIES: sodium:solute symporter [Salmonella]

Protein Classification

sodium:solute symporter( domain architecture ID 10183812)

sodium:solute symporter co-transports Na(+) with a variety of solutes such as sugars, amino acids, inorganic ions or vitamins; similar to Aliivibrio fischeri N-acetylneuraminate transporter and Proteus mirabilis Na(+)-coupled sialic acid symporter

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SLC5sbd_NIS-like_u3 cd11495
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
6-479 0e+00

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


:

Pssm-ID: 271386 [Multi-domain]  Cd Length: 473  Bit Score: 534.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739   6 FGIVNYLVLFGYLLAMMLVGVYFSRRQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIIGQYLA 85
Cdd:cd11495    1 FGWLDYLVLVIYLLAMLGIGLYFSKKQKSTDDYFKGGGRIPWWAAGLSIFATTLSSITFLAIPGKAYATDWNYFVGSLSI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  86 IAILPLVFYFYIPFFRKLKVTSAYEYLEARFDVRCRLFASMSFMLFHIGRIAIITFLTVLALRPFIAIDPVILVLLISVM 165
Cdd:cd11495   81 IIAAPLAAYFFVPFFRRLNVTSAYEYLEKRFGPWARVYGSLLFILFQLGRMGIVLYLPALALSAVTGINPYIIIILMGVL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 166 CIIYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVICLKVQGGIGEIFTVTQQADKFFPATqFHWSWTESTVPVLMIGFLF 245
Cdd:cd11495  161 CIIYTVLGGIEAVIWTDVIQGVVLLGGALLCLIILLFSIPGGFGEVFDIAIANGKFSLGD-FSFSLTESTIWVIFIGGIF 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 246 ANIQQFTASQDVVQRYIVTDSIEETKKTLLTNAKLVAVIPVFFFAIGSALFVYYQQHPQLLPAGFNTGGILPLFVVTEMP 325
Cdd:cd11495  240 NNLQSYTSDQDVVQRYLTTKSIKEAKKSLWTNALLALPVALLFFGIGTALYVFYQQHPELLPAGINGDAVFPYFIVTQLP 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 326 VGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLShKKRTPENRMKIAKLVILVAGLISSAASVWLVMADESEIWD 405
Cdd:cd11495  320 VGVAGLIIAAIFAAAMSTISSSLNSVATCITTDFYKRLS-PDPSDKQYLKVARLITLLVGLLGTLVALYLANAGVKSLLD 398
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446550739 406 AFNSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGIIISVITVLGAR-YATDLNFFFYGVIGSLSVVISGVIFAPL 479
Cdd:cd11495  399 AFNTLTGLFGGGLAGLFLLGIFTKRANAKGALVGIIVSIIVIFWISlLYTPIHFFLYSVIGTLVCFVVGYVVSLL 473
 
Name Accession Description Interval E-value
SLC5sbd_NIS-like_u3 cd11495
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
6-479 0e+00

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271386 [Multi-domain]  Cd Length: 473  Bit Score: 534.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739   6 FGIVNYLVLFGYLLAMMLVGVYFSRRQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIIGQYLA 85
Cdd:cd11495    1 FGWLDYLVLVIYLLAMLGIGLYFSKKQKSTDDYFKGGGRIPWWAAGLSIFATTLSSITFLAIPGKAYATDWNYFVGSLSI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  86 IAILPLVFYFYIPFFRKLKVTSAYEYLEARFDVRCRLFASMSFMLFHIGRIAIITFLTVLALRPFIAIDPVILVLLISVM 165
Cdd:cd11495   81 IIAAPLAAYFFVPFFRRLNVTSAYEYLEKRFGPWARVYGSLLFILFQLGRMGIVLYLPALALSAVTGINPYIIIILMGVL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 166 CIIYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVICLKVQGGIGEIFTVTQQADKFFPATqFHWSWTESTVPVLMIGFLF 245
Cdd:cd11495  161 CIIYTVLGGIEAVIWTDVIQGVVLLGGALLCLIILLFSIPGGFGEVFDIAIANGKFSLGD-FSFSLTESTIWVIFIGGIF 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 246 ANIQQFTASQDVVQRYIVTDSIEETKKTLLTNAKLVAVIPVFFFAIGSALFVYYQQHPQLLPAGFNTGGILPLFVVTEMP 325
Cdd:cd11495  240 NNLQSYTSDQDVVQRYLTTKSIKEAKKSLWTNALLALPVALLFFGIGTALYVFYQQHPELLPAGINGDAVFPYFIVTQLP 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 326 VGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLShKKRTPENRMKIAKLVILVAGLISSAASVWLVMADESEIWD 405
Cdd:cd11495  320 VGVAGLIIAAIFAAAMSTISSSLNSVATCITTDFYKRLS-PDPSDKQYLKVARLITLLVGLLGTLVALYLANAGVKSLLD 398
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446550739 406 AFNSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGIIISVITVLGAR-YATDLNFFFYGVIGSLSVVISGVIFAPL 479
Cdd:cd11495  399 AFNTLTGLFGGGLAGLFLLGIFTKRANAKGALVGIIVSIIVIFWISlLYTPIHFFLYSVIGTLVCFVVGYVVSLL 473
PutP COG0591
Na+/proline symporter [Amino acid transport and metabolism];
8-490 5.73e-73

Na+/proline symporter [Amino acid transport and metabolism];


Pssm-ID: 440356 [Multi-domain]  Cd Length: 476  Bit Score: 238.56  E-value: 5.73e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739   8 IVNYLVLFGYLLAMMLVGVYFSRRQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIIGQYLAIA 87
Cdd:COG0591    3 TLDLIIIILYLLLLLGIGLYASRRTKSLEDYFLAGRSLGWWVLALSLGATWLSAWTFLGVPGLAYAYGLSALWYALGYAL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  88 ILPLVFYFYIPFFRKLKVTSAYEYLEARFDVRCRLFASMSFMLFHIGRIAIITFLTVLALRPFIAIDPVILVLLISVMCI 167
Cdd:COG0591   83 GALLLALFFAPRLRRLGALTIPEFLEKRFGRGLRLLAAIIILLFLLGYLAAQLVALGKLLEALFGIPYWLGILIGALIVL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 168 IYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVICLKVqGGIGEIFTVTQQADKFFPatqfhWSWTESTVPVLMIGFLFAN 247
Cdd:COG0591  163 LYTVLGGLRAVAWTDVLQGILMLVGLILLLIVALSAL-GGFGELFAALPAPGLLSL-----FPGLGFTGWLAFLGLFLAI 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 248 IQQFTASQDVVQRYIVTDSIEETKKTLLTNAKLVAVIPVFFFAIGSALFVYYQQHPqllpaGFNTGGILPLFVVTEMPVG 327
Cdd:COG0591  237 GLGYFGQPHIVQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLLARALFPDLP-----LADPDLALPLLILELLPPG 311
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 328 IAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLSHKKRTPENRMKIAKLVILVAGLIssaaSVWLVMADESEIWDAF 407
Cdd:COG0591  312 LAGLLLAAILAAAMSTADSQLLAASSVFTRDIYKPFIKPKASDKQLLRVSRLAVLVVGLL----ALLLALLFPSSILDLV 387
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 408 NSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGIIISVITVLGARY----ATDLNFFFYGVIGSLSVVISGVIFAPLFAPA 483
Cdd:COG0591  388 LLAWGGLGAALLPPLLLGLFWKRATKAGALAGMIAGLVVVLLWKLlggpLGPFGWLYPILPGLLVSLLVFVVVSLLTKPP 467

                 ....*..
gi 446550739 484 PPLTLDE 490
Cdd:COG0591  468 SEEVLEE 474
sss TIGR00813
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ...
41-443 2.47e-33

transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273282 [Multi-domain]  Cd Length: 407  Bit Score: 130.50  E-value: 2.47e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739   41 GGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIIGQYLAIAILPLVFYFYIPFFRKLKVTSAYEYLEARFDVRC 120
Cdd:TIGR00813   1 AGRSLGGWVVAASLFASYISASQFLGLPGAIYAYGFAIGFYELGALVLLIILGWLFVPIFINNGAYTMPEYLEKRFGKRI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  121 -RLFASMSFMLFHIGRIAIITFLTVLALRPFIAIDPVILVLLISVMCIIYTWMGGIEGVIWTDVIQGLLLSGSAILIFIV 199
Cdd:TIGR00813  81 lRGLSVLSLILYIFLYMSVDLFSGALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILGTFILPVF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  200 ICLKVqGGIGEIFTVTQQADK--FFPATQFHWSWTEST----VPVLMIGFLFANIQQFTaSQDVVQRYIVTDSIEETKKT 273
Cdd:TIGR00813 161 AFSEV-GGLGTFVEKASQAAPtnPSPDDLYDFFRDPSTsdlpWGAGVFGLPHVALWYWT-NQVIVQRCLAAKSAKHAKKG 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  274 LLTNAKLVAVIPVFFFAIGSALFVYYQQHPQLLPAGF--NTGGILPLFVVTEMPVGIAGLIIAAIFAAAQSSISSSLNSI 351
Cdd:TIGR00813 239 CLISGVLKLLPMFGAVLPGLIARALYTDIDPALAGAVnqNSDQAYPLLVQELMPPGLAGLFLAAILAAVMSTLSSQLNSA 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  352 SSCFNSDIYQRLshKKRTPENRMKIA-KLVILVAGLISSAasvWLVMADESE-IWDAFNSLIGLMGGPMTGLFMLGIFFK 429
Cdd:TIGR00813 319 STVFTMDLYKKI--IRPNASGEKKIVmRGRIAVLVAAVIA---GFVAAAQGGqVLQYVQEAFGGLGAPFLPVFLLGIFWK 393
                         410
                  ....*....|....
gi 446550739  430 RANAGSAVLGIIIS 443
Cdd:TIGR00813 394 RMNAKGALAGMIAG 407
PRK10484 PRK10484
putative transporter; Provisional
12-477 1.55e-17

putative transporter; Provisional


Pssm-ID: 236699 [Multi-domain]  Cd Length: 523  Bit Score: 85.32  E-value: 1.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  12 LVLFGYLLAMMLVGV---YFSRRQK--TADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSdwTFIIGQYLAI 86
Cdd:PRK10484   2 LTILSFLGFTLLVAViswWKTRKTDtsSSDGYFLAGRSLTGPVIAGSLLLTNLSTEQLVGLNGQAYAS--GMSVMAWEVT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  87 AILPLVF--YFYIPFFRKLKVTSAYEYLEARFDVRCRLFASMSFMLFHI----------GRIA---IITFLTVLALRPFI 151
Cdd:PRK10484  80 AAIALIIlaLIFLPRYLKSGITTIPDFLEERYDKTTRRIVSILFLIGYVvsflpivlysGALAlnsLFHVSELLGISYGA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 152 AIdpVILVLLISVMCIIYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVICLKV-QGGIGEIFT--VTQQADKF----FPA 224
Cdd:PRK10484 160 AI--WLLVWLIGIIGAIYAVFGGLKAVAVSDTINGIGLLIGGLLVPVFGLIALgDGSFMQGLEqlTTVHPEKLnsigGAT 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 225 TQFHWswtestvPVLMIGFLFANIQQFTASQDVVQRYIVTDSIEETKKTLLTNAKLVAVIPVFFFAIGSALFVYYQqhPQ 304
Cdd:PRK10484 238 DPVPF-------PTLFTGLILVNLFYWCTNQSIVQRALGAKNLAEGQKGALLAAFFKLLGPLILVLPGIIAFHLYG--DG 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 305 LLPAGFntggILPLFVVTEMPVGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLSHKKRTPENRMKIAKLVILVA 384
Cdd:PRK10484 309 LPNADM----AYPTLVNDVLPVPLVGFFAAVLFGAILSTFNGFLNSASTLFSLDIYKPIINPNASEKQLVKVGKKFGFVL 384
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 385 GLISSAASVWLVMADESeIWDAFNSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGIIISVITVLGARYATDLNFFFYGVI 464
Cdd:PRK10484 385 AIISMIVAPLIANAPQG-LYSYLQQLNGIYNVPILAIIIVGFFTKRVPALAAKVALGFGIILYIIINFVLKFDIHFLYVL 463
                        490
                 ....*....|...
gi 446550739 465 GSLSVVISGVIFA 477
Cdd:PRK10484 464 AILFVINVVVMLI 476
SSF pfam00474
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ...
38-442 8.34e-17

Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.


Pssm-ID: 109527 [Multi-domain]  Cd Length: 406  Bit Score: 82.39  E-value: 8.34e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739   38 YFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIIGQYLAIAILPLVFYFYIPFFRKLKVTSAYEYLEARFD 117
Cdd:pfam00474   1 YFLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAASGLAGGLYAIGALVGVWLLLWLFAPRLRNLGAYTMPDYLRKRFG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  118 VR--CRLFASMSFMLFHIGRIAIITFLTVLALRPFIAIDPVILVLLISVMCIIYTWMGGIEGVIWTDVIQGLLLSGSAIL 195
Cdd:pfam00474  81 GKriLVYLSALSLLLYFFTYMSVQIVGGARLIELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVLMLFGTII 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  196 IFIVICLKVqGGIGEIF----TVTQQADKFFPATQFHWSWTESTVPVLMIGFLFANIQQftasQDVVQRYIVTDSIEETK 271
Cdd:pfam00474 161 LMIIVFHEV-GGYSSAVekymTADPNGVDLYTPDGLHILRDPLTGLSLWPGLVLGTTGL----PHILQRCLAAKDAKCIR 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  272 KTLLTNAKLVAVIPVFFFAIGSALFVYYQQHPQLlpAGFNTGG---ILPLFVVTEMPVGIAGLIIAAIFAAAQSSISSSL 348
Cdd:pfam00474 236 CGVLILTPMFIIVMPGMISRGLFAIALAGANPRA--CGTVVGCsniAYPTLAVKLGPPGLAGIMLAVMLAAIMSTLTSQL 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  349 NSISSCFNSDIYQRLshKKRTPENRMKIAKLVILVAGLISSAASVWLVMADESEIWDAFNSLIGLMGGPMTGLFMLGIFF 428
Cdd:pfam00474 314 LSSSSAFTHDLYKNI--RRKASATEKELVGRSRIIVLVVISLAILLAVQPAQMGIAFLVQLAFAGLGSAFLPVILLAIFW 391
                         410
                  ....*....|....
gi 446550739  429 KRANAGSAVLGIII 442
Cdd:pfam00474 392 KRVNEQGALWGMII 405
 
Name Accession Description Interval E-value
SLC5sbd_NIS-like_u3 cd11495
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
6-479 0e+00

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271386 [Multi-domain]  Cd Length: 473  Bit Score: 534.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739   6 FGIVNYLVLFGYLLAMMLVGVYFSRRQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIIGQYLA 85
Cdd:cd11495    1 FGWLDYLVLVIYLLAMLGIGLYFSKKQKSTDDYFKGGGRIPWWAAGLSIFATTLSSITFLAIPGKAYATDWNYFVGSLSI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  86 IAILPLVFYFYIPFFRKLKVTSAYEYLEARFDVRCRLFASMSFMLFHIGRIAIITFLTVLALRPFIAIDPVILVLLISVM 165
Cdd:cd11495   81 IIAAPLAAYFFVPFFRRLNVTSAYEYLEKRFGPWARVYGSLLFILFQLGRMGIVLYLPALALSAVTGINPYIIIILMGVL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 166 CIIYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVICLKVQGGIGEIFTVTQQADKFFPATqFHWSWTESTVPVLMIGFLF 245
Cdd:cd11495  161 CIIYTVLGGIEAVIWTDVIQGVVLLGGALLCLIILLFSIPGGFGEVFDIAIANGKFSLGD-FSFSLTESTIWVIFIGGIF 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 246 ANIQQFTASQDVVQRYIVTDSIEETKKTLLTNAKLVAVIPVFFFAIGSALFVYYQQHPQLLPAGFNTGGILPLFVVTEMP 325
Cdd:cd11495  240 NNLQSYTSDQDVVQRYLTTKSIKEAKKSLWTNALLALPVALLFFGIGTALYVFYQQHPELLPAGINGDAVFPYFIVTQLP 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 326 VGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLShKKRTPENRMKIAKLVILVAGLISSAASVWLVMADESEIWD 405
Cdd:cd11495  320 VGVAGLIIAAIFAAAMSTISSSLNSVATCITTDFYKRLS-PDPSDKQYLKVARLITLLVGLLGTLVALYLANAGVKSLLD 398
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446550739 406 AFNSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGIIISVITVLGAR-YATDLNFFFYGVIGSLSVVISGVIFAPL 479
Cdd:cd11495  399 AFNTLTGLFGGGLAGLFLLGIFTKRANAKGALVGIIVSIIVIFWISlLYTPIHFFLYSVIGTLVCFVVGYVVSLL 473
SLC5sbd_NIS-like cd10326
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ...
10-476 2.66e-75

Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and 2. SMCT1(the product of the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (product of the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271361 [Multi-domain]  Cd Length: 472  Bit Score: 244.78  E-value: 2.66e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  10 NYLVLFGYLLAMMLVGVYFSRRQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIIGQYLAIAIL 89
Cdd:cd10326    1 DWAVVVVYFLILLAISYYTSRRNADNDDFFLGNRQSPWYLVAFSMIGTSLSGVTFVSVPGEVGGSGFTYLQMVLGFLLGY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  90 PLVFYFYIPFFRKLKVTSAYEYLEARFDVRCRLFASMSFMLFHIGRIAIITFLTVLALRPFIAIDPVI----LVLLISVM 165
Cdd:cd10326   81 LIIAFVLLPLYYRLNLTSIYEYLEDRFGVSSRKTGAVFFLLSRILGAGIRLYLVALVLQQFLFDSLGIpfwlTVLITGLL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 166 CIIYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVICLKVQGGIGEIFTVTQQADKFfpaTQFHWSWTES--TVPVLMIGF 243
Cdd:cd10326  161 IWLYTFRGGIKTVVWTDTLQTVFLLVGLVLTIIIISNSLGLGFGEAISAAGESGYS---RIFNFDDDNSrrTFWKQFLGG 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 244 LFANIQQFTASQDVVQRYIVTDSIEETKKTLLTNAKLVAVIPVFFFAIGSALFVYYQQHPQLLPAGfNTGGILPLFVVTE 323
Cdd:cd10326  238 IFITIAMTGLDQDMMQRNLSCKNLKDAQKNMLTFGVILVPVNLLFLLLGVLLYTYAQKNGIALPAK-DSDQLFPYFALNG 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 324 MPVGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLSHKKRTPENR--MKIAKLVILVAGLIssaasVWLVMADES 401
Cdd:cd10326  317 LPPGVSGLFVAGIIAAAMSSADSALTALTTSFCVDILNRFKRKSEKKSERkyVHIAFSLTFVLGIL-----VFGSASNSG 391
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 402 EIWDAFNSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGI-----IISVITVLGARYATDLNFFFYGVIGSLSVVISGVIF 476
Cdd:cd10326  392 SLIDAIFKVAGYTYGPLLGLFAFGLFTKRAVKDKWVPLVgllapVLSYLLVSNSEGFFGYKFGFELLIINGLLTFLGLLL 471
PutP COG0591
Na+/proline symporter [Amino acid transport and metabolism];
8-490 5.73e-73

Na+/proline symporter [Amino acid transport and metabolism];


Pssm-ID: 440356 [Multi-domain]  Cd Length: 476  Bit Score: 238.56  E-value: 5.73e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739   8 IVNYLVLFGYLLAMMLVGVYFSRRQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIIGQYLAIA 87
Cdd:COG0591    3 TLDLIIIILYLLLLLGIGLYASRRTKSLEDYFLAGRSLGWWVLALSLGATWLSAWTFLGVPGLAYAYGLSALWYALGYAL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  88 ILPLVFYFYIPFFRKLKVTSAYEYLEARFDVRCRLFASMSFMLFHIGRIAIITFLTVLALRPFIAIDPVILVLLISVMCI 167
Cdd:COG0591   83 GALLLALFFAPRLRRLGALTIPEFLEKRFGRGLRLLAAIIILLFLLGYLAAQLVALGKLLEALFGIPYWLGILIGALIVL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 168 IYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVICLKVqGGIGEIFTVTQQADKFFPatqfhWSWTESTVPVLMIGFLFAN 247
Cdd:COG0591  163 LYTVLGGLRAVAWTDVLQGILMLVGLILLLIVALSAL-GGFGELFAALPAPGLLSL-----FPGLGFTGWLAFLGLFLAI 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 248 IQQFTASQDVVQRYIVTDSIEETKKTLLTNAKLVAVIPVFFFAIGSALFVYYQQHPqllpaGFNTGGILPLFVVTEMPVG 327
Cdd:COG0591  237 GLGYFGQPHIVQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLLARALFPDLP-----LADPDLALPLLILELLPPG 311
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 328 IAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLSHKKRTPENRMKIAKLVILVAGLIssaaSVWLVMADESEIWDAF 407
Cdd:COG0591  312 LAGLLLAAILAAAMSTADSQLLAASSVFTRDIYKPFIKPKASDKQLLRVSRLAVLVVGLL----ALLLALLFPSSILDLV 387
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 408 NSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGIIISVITVLGARY----ATDLNFFFYGVIGSLSVVISGVIFAPLFAPA 483
Cdd:COG0591  388 LLAWGGLGAALLPPLLLGLFWKRATKAGALAGMIAGLVVVLLWKLlggpLGPFGWLYPILPGLLVSLLVFVVVSLLTKPP 467

                 ....*..
gi 446550739 484 PPLTLDE 490
Cdd:COG0591  468 SEEVLEE 474
SLC5sbd_NIS-like_u2 cd11494
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
10-476 2.00e-72

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters, SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271385 [Multi-domain]  Cd Length: 473  Bit Score: 237.11  E-value: 2.00e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  10 NYLVLFGYLLAMMLVGVYFSRRQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFI---IGQYLAI 86
Cdd:cd11494    2 DWIVLVGYLLGILVYGVYKGRGQKNQEDYFLGGRSMPWWPIGLSIMATQASAITFLSAPGQAYSDGMRFVqyyFGLPLAM 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  87 AILPLVFyfyIPFFRKLKVTSAYEYLEARFDVRCRLFASMSFMLFHIGRIAIITFLTVLALRPFIAIDPVILVLLISVMC 166
Cdd:cd11494   82 IFLCITF---VPVFYKLKVYTAYEYLERRFGLKTRLLTSILFLISRGLATGVTIYAPAIILSTILGWSLWLTILLIGGIT 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 167 IIYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVICLKVQGGIGEIFTVTQQADKFFPATQFHWSWTESTVPVLMIGFLFA 246
Cdd:cd11494  159 IIYTVLGGIKAVIWTDVIQMVIIWAGLFIAFGLLLKLLPVGFVDALLVAGKSGRLNALDFSFDLSDTYTFWSGLIGGFFL 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 247 NIQQFTASQDVVQRYIVTDSIEETKKTLLTNAkLVAVIPVFFFA-IGSALFVYYQQHPqlLPAGFNTGG--------ILP 317
Cdd:cd11494  239 YLSYFGTDQSQVQRYLTAKSIKEARKSLLLNG-FLKFPMQFFILlIGVLVFVFYQFNP--FPVSFNPAEdetkdtnyIFL 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 318 LFVVTEMPVGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLSHKKRTPENRMKIAKLVILVAGLISSAASVWLVM 397
Cdd:cd11494  316 RFVLNYLPPGVIGLLIAAIFAAAMSSIDSALNSLATVTVIDIYRRFFKKDASDEHYLKVSRLLTVFWGLLAIVFALFAGL 395
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446550739 398 ADesEIWDAFNSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGIIISVITVLGARYATDLNFFFYGVIGSLSVVISGVIF 476
Cdd:cd11494  396 AG--SLIEAVNKLGSLFYGPILGVFLLAFFTKKANGKGVFAGAILGVIVVIVLWLFPDVSWLWWNVIGCVVVIGVALLL 472
SLC5sbd_NIS-SMVT cd11492
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ...
9-448 1.69e-57

Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (encoded by the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (encoded by the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and -2. SMCT1(encoded by the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (encoded by the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271383 [Multi-domain]  Cd Length: 522  Bit Score: 198.86  E-value: 1.69e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739   9 VNYLVLFGYLLAMMLVGVYF---SRRQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAF---TSDWTFIIGQ 82
Cdd:cd11492    1 VDYVVFVAMLLISAAIGIYFgffGGKQKTTEEYLLGGRNMSVFPVALSLIASFISGITLLGTPAEIYyygTQYWLIVIAY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  83 YLAIailPLVFYFYIPFFRKLKVTSAYEYLEARFDVRCRLFASMSFMLFHIGRIAIITFLTVLALRPFIAIDPVILVLLI 162
Cdd:cd11492   81 VLVG---PITAYIFLPVFYNLQLTSVYEYLELRFNRRVRLLASFLFILQMLLYLPIVIYAPALALSQVTGINLHIIILVV 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 163 SVMCIIYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVICLKVqGGIGEIFTVTQQADKFfpaTQFHWSW---TESTVPVL 239
Cdd:cd11492  158 GIVCIFYTTLGGLKAVVWTDVFQVVVMFGGVLAVIILGTIDV-GGFSEVWEIAEEGGRL---EFFNFDPdptVRHTFWSL 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 240 MIGFLFANIQQFTASQDVVQRYIVTDSIEETKKTLLTNAKLVAVIPVFFFAIGSALFVYYQQ-----------HPQLLP- 307
Cdd:cd11492  234 VIGGTFTWLSLYGVNQTQVQRYLSLPSLKSAKKALWLNIVGLILILSLCCFTGLVIYAKYHDcdpltaglikkPDQLLPy 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 308 -----AGFNTGgiLP-LFVVTEMPVGiagliiaaifaaaqssisssLNSISSCFNS-------DIYQRLSHKKRTPENRM 374
Cdd:cd11492  314 fvmdvLGHLPG--LPgLFVAGIFSAA--------------------LSTLSSGLNSlaavileDFIKPFFKKKLSERQAT 371
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446550739 375 KIAKLVILVAGLISSAasVWLVMADESEIWDAFNSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGIIISVITVL 448
Cdd:cd11492  372 NIMKLLVVVFGLLCIG--LAFLVEKLGGVLQLSLSIFGITGGPLLGIFTLGMFFPWANSKGALVGLLVGLIFML 443
SLC5sbd_NIS-like_u1 cd11493
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
11-448 5.52e-57

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271384 [Multi-domain]  Cd Length: 479  Bit Score: 196.67  E-value: 5.52e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  11 YLVLFGYLLAMMLVGVYFSRRQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFI---IGQYLAIA 87
Cdd:cd11493    2 LAVIVLYLLGLPLLGLWLSGRQKSTADYFLGGRSMPWWAVCLSVVATETSTLTFLSIPGLAYGGDLTFLqlaLGYILGRI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  88 IlplVFYFYIPFFRKLKVTSAYEYLEARFDVRCRLFASMSFMLFHI----GRIAIITFLTVLALRPFIAIDPVIL-VLLI 162
Cdd:cd11493   82 I---VAFVLLPRYFRGEVVSAYELLGQRFGGGMQKTASVTFLVTRLladgVRLFAAAIPVSMILGADGVALSYIAsILII 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 163 SVMCIIYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVICLKVQGGIGEIFTVTQQADKFFPATQFHWSWTESTVPVLMIG 242
Cdd:cd11493  159 SVVTLLYTYFGGIRAVVWTDVIQLVVYIGGAVAALAYLLGALPADWLQIAAAAGKFHLFDLSDLILGLTSPYTFWAAIIG 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 243 FLFANIQQFTASQDVVQRYIVTDSIEETKKTLLTNAklVAVIPVF--FFAIGSALFVYYQQHPQLLPAGFNTGGILPLFV 320
Cdd:cd11493  239 GALLSMASHGTDQLMVQRLLACRNLRDAQKALIGSG--VVVFPQFalFLLIGLLLYVYYGGASLAALGLGSPDEVFPYFI 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 321 VTEMPVGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLSHKKRTPENRMKIAKLVILVAGLISSAASvWLVMADE 400
Cdd:cd11493  317 VHELPAGLRGLLIAGILAAAMSTLSSALNSLASSTVQDLYQPWKRRRLSDEKLLRASRLLTLVWAVVLVGIA-LLFQYTD 395
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*...
gi 446550739 401 SEIWDAFNSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGIIISVITVL 448
Cdd:cd11493  396 QPVVELGLSIASFTYGGLLGVFLLGLLTRRASQRDAIAAFIVGFLVML 443
YidK COG4146
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function ...
4-445 1.15e-42

Uncharacterized membrane permease YidK, sodium:solute symporter family [General function prediction only];


Pssm-ID: 443317 [Multi-domain]  Cd Length: 444  Bit Score: 157.23  E-value: 1.15e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739   4 HSFGIVNYLVLFGYLLAMMLVGVYFSRR--QKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDwtFIIG 81
Cdd:COG4146    1 MGLSTLDYIVFLLYFLLVAGIGYWVSRKkkEKTSEDYFLAGRSLTWWVIGASLIATNISAEQLIGLNGSGYATG--LAVA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  82 QYLAIAILPLVF--YFYIPFFRKLKVTSAYEYLEARFDVRCRLFASMSFMLFHIG-RIAIITFLTVLALRPFIAIDPVIL 158
Cdd:COG4146   79 AYEWMAAIALIIlaLFFLPFYLKSGIYTMPEFLEKRYDRRTRTILSILFLVSYVFvNLPSVLYAGALALNTIFGVPLWIS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 159 VLLISVMCIIYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVICLKV-----QGGIGEIFTVTqqADKF---FPATQFHWS 230
Cdd:COG4146  159 VIGLGIIAGIYTIFGGLKAVAYTDVIQGIGLIIGGLLITVLGLDAVgdgsvLAGWSALLKVP--PEKFnmiGPADDPDLP 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 231 WtestvPVLMIGFLFANIQQFTASQDVVQRYIVTDSIEETKKTLLTNAKLVAVIPVFFFAIGSALFVYYQQHPQllpagf 310
Cdd:COG4146  237 W-----LGIFTGMPILNLFYWGTNQYIVQRALGAKNLKEAQKGVLFAGFLKLLIPFIVVLPGIIAFVLFPDGLD------ 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 311 NTGGILPLFVVTEMPVGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLSHKKRTPENRMKIAKLVILVAGLISSA 390
Cdd:COG4146  306 NPDQAYPTLVKNLLPVGLKGLVAAALFAAIMSSLASALNSSSTLFTLDIYKKYFNPNASEKQLVKVGRIATVVLAVIAIL 385
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446550739 391 ASVWLVMADesEIWDAFNSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGIIISVI 445
Cdd:COG4146  386 IAPLIGNAD--GLFQYIQEVTGFFSPPILAVFLLGLFWKRVTAKAAKVALIAGIV 438
SLC5sbd cd10322
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ...
11-471 1.92e-41

Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.


Pssm-ID: 271357 [Multi-domain]  Cd Length: 454  Bit Score: 153.86  E-value: 1.92e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  11 YLVLFGYLLAMMLVGVYFSRRQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIIGQYLAIAILP 90
Cdd:cd10322    3 LIIVVVYLALLLGIGLYASKKVKSSEDFFLAGRSLGPWLLAGTLAATWISAGSFVGVAGLAYTYGLSAIWYILGAALGAL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  91 LVFYFYIPFFRKLKVTSAYEYLEARFDVRC-RLFASMSFMLFHIGRIAIITFLTVLALRPFIAIDPVILVLLISVMCIIY 169
Cdd:cd10322   83 LLALFLAPRLRRLGKTTIPETILERYYSKGlRLLVAIIIIIALIPYLALQLIGGGYILSTLLGIPYTVAVIIAAVIVILY 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 170 TWMGGIEGVIWTDVIQGLLLSGSAILIFIVICLKVQG-GIGEIFTVTqqadkffPATQFHWSWTESTVPVLMIGFLFANI 248
Cdd:cd10322  163 TVFGGMRAVAWTDVIQGIVMLIGVLVAAIFILSKVGGgGFSALAAAL-------PALLLALGPGGGLGWSTILSLILLTG 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 249 QQFTASQDVVQRYIVTDSIEETKKTLLTNAKLVAVIPVFFFAIGSALFVYYqqhpqllPAGFNTGGILPLFVVTEMPVGI 328
Cdd:cd10322  236 LGVLALPQVFQRILAAKDEKTARRAFLLAGLLLLLIGFLVALIGLAARALF-------PDLENPDLALPTLINSLLPPGL 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 329 AGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLSHKKRTPENRMKIAKLVILVAGLISSAASVWLvmadeSEIWDAFN 408
Cdd:cd10322  309 AGLVLAGLLAAAMSTADSLLLAASTLFTRDIYKPLINPKASDKKLLRVSRIAVVVVGVLALLLALLP-----PSILLLLS 383
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446550739 409 SLIGLMGGPMTGLFMLGIFFKRANAGSAVLGIIISVITVLGARY-----ATDLNFFFYGVIGSLSVVI 471
Cdd:cd10322  384 LAAGLLAAALFPPLLGGLFWKRATKAGAIAGIIVGLIVTLVWLLlplasPLGIDPIIPALLVSLIVFV 451
SLC5sbd_u1 cd11477
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
11-490 2.93e-37

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271371  Cd Length: 493  Bit Score: 143.11  E-value: 2.93e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  11 YLVLFGYLLAMMLVGVYFSRR-QKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIIGQyLAIAIL 89
Cdd:cd11477    3 WLVIALYFLLMLGIGLWFSKRaSKSTSDFFLGGRKLPWWLAGISMAATTFSADTFVAVAGIAYTYGIAGNWIW-WLWAVA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  90 PLVFYFYI-PFFRKLKVTSAY----EYLEARFDVRCRLFASMSFMLFHIgrIAIITFLTVLALR---PFIAIDPVILVLL 161
Cdd:cd11477   82 GLIGAFVFaRRWRRLRVLTDGefpeERYGGRYGAPLRQFYAVYFALLSN--VDILAWVFLAAIKvsaVFGPWDPWLTILI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 162 ISVMCIIYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVICLKVqGGIGEIFTvtQQADKFFPatqFHWSWTESTVPVLMI 241
Cdd:cd11477  160 LGLITLIYTVIGGLWAVVVTDVVQFVIAMAASIAVAVLALNAV-GGPGGLFA--QLPEGHLD---LFGSGLGASGFYITF 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 242 GF-LFANIQQFTASQD---VVQRYIVTDSIEETKKTLLTNAKLVAVIPVFFFAIGsalFVYYQQHPQLLPAGFNTGGILP 317
Cdd:cd11477  234 FFiLFFGWYPLSYSGGgwyLAQRYLSAKSEKAAKAAAWLFAALYLVRPWPWMLPA---LAALVLYPDLDDPEADFELAYP 310
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 318 LFVVTEMPVGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLSHKKRTPENRMKIAKLVILVAGLISSAASvwLVM 397
Cdd:cd11477  311 MMIKEYLPAGLLGLVLAGLLAATMSTVSTHLNWGAAYLVNDIYKRFIKPNASEKHLLKVGRLATVLFGLLSIVVA--LAS 388
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 398 ADESEIWDAFNSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGIIISVIT-VLGARYATDLNFFFYGVIGSLSVVISGVIF 476
Cdd:cd11477  389 DSIGGAFWIVLALGAGLGGPLILPWLWWRFNAWTEIWAMIASIIVGLVVsVLLKVFGLPEDFLFSFLVPVLLSLVVWLAV 468
                        490
                 ....*....|....
gi 446550739 477 APLFAPAPPLTLDE 490
Cdd:cd11477  469 TLLTPPTDEETLVA 482
sss TIGR00813
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ...
41-443 2.47e-33

transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273282 [Multi-domain]  Cd Length: 407  Bit Score: 130.50  E-value: 2.47e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739   41 GGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIIGQYLAIAILPLVFYFYIPFFRKLKVTSAYEYLEARFDVRC 120
Cdd:TIGR00813   1 AGRSLGGWVVAASLFASYISASQFLGLPGAIYAYGFAIGFYELGALVLLIILGWLFVPIFINNGAYTMPEYLEKRFGKRI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  121 -RLFASMSFMLFHIGRIAIITFLTVLALRPFIAIDPVILVLLISVMCIIYTWMGGIEGVIWTDVIQGLLLSGSAILIFIV 199
Cdd:TIGR00813  81 lRGLSVLSLILYIFLYMSVDLFSGALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILGTFILPVF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  200 ICLKVqGGIGEIFTVTQQADK--FFPATQFHWSWTEST----VPVLMIGFLFANIQQFTaSQDVVQRYIVTDSIEETKKT 273
Cdd:TIGR00813 161 AFSEV-GGLGTFVEKASQAAPtnPSPDDLYDFFRDPSTsdlpWGAGVFGLPHVALWYWT-NQVIVQRCLAAKSAKHAKKG 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  274 LLTNAKLVAVIPVFFFAIGSALFVYYQQHPQLLPAGF--NTGGILPLFVVTEMPVGIAGLIIAAIFAAAQSSISSSLNSI 351
Cdd:TIGR00813 239 CLISGVLKLLPMFGAVLPGLIARALYTDIDPALAGAVnqNSDQAYPLLVQELMPPGLAGLFLAAILAAVMSTLSSQLNSA 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  352 SSCFNSDIYQRLshKKRTPENRMKIA-KLVILVAGLISSAasvWLVMADESE-IWDAFNSLIGLMGGPMTGLFMLGIFFK 429
Cdd:TIGR00813 319 STVFTMDLYKKI--IRPNASGEKKIVmRGRIAVLVAAVIA---GFVAAAQGGqVLQYVQEAFGGLGAPFLPVFLLGIFWK 393
                         410
                  ....*....|....
gi 446550739  430 RANAGSAVLGIIIS 443
Cdd:TIGR00813 394 RMNAKGALAGMIAG 407
SLC5sbd_SGLT1-like cd10329
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily ...
11-467 2.97e-32

Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily includes the solute-binding domain of SGLT proteins that cotransport Na+ with various solutes. Its members include: the human glucose (SGLT1, -2, -4, -5 ), chiro-inositol (SGLT5), and myo-inositol (SMIT) cotransporters. It also includes human SGLT3 which has been characterized as a glucose sensor and not a transporter. It belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271363  Cd Length: 538  Bit Score: 129.62  E-value: 2.97e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  11 YLVLFGYLLAMMLVGVYFSRRQK-TADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDwtFIIGQYLAIAIL 89
Cdd:cd10329    1 IVIIAVYFVAVIAIGLWSSRKKRsTVSGYFLAGRSMGWPVIGASLFASNIGSSHLVGLAGSGAASG--IAVGNYEWNAAF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  90 PLVF--YFYIPFFRKLKVTSAYEYLEARFDVRCRL-FASMSFMLFHIGRIAIITFLTVLALRPFIAIDPVILVLLISVMC 166
Cdd:cd10329   79 VLLLlgWVFLPFYIRSGVSTMPEFLEKRFGGRSRVyLSVLSLILYVFTKISVDLYAGALVIKQLLGWDLYLSIIVLLVIT 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 167 IIYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVICLKVQGGIGEIFTVTQQADKFF---PATQFHWSWtestvPVLMIGF 243
Cdd:cd10329  159 AIYTIAGGLKAVIYTDTLQAVILIIGSAILMFLAFNEVGGGWSAYMAAIPSGTAFHlfrPPDDPDLPW-----PGLLLGY 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 244 LFANIQQFTASQDVVQRYIVTDSIEETKK-TLLtnAKLVAVIPVFFFAI-GSALFVYYQQ----HPQLLPAGFNTGGILP 317
Cdd:cd10329  234 PILGIWYWCTDQVIVQRVLAAKNLKHARRgALF--AGYLKLLPLFLMVLpGMIARALFPDlvacVVPCGNGVGCSDIAYP 311
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 318 LFVVTEMPVGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLshKKRTPENRMKIAKLVILVAGLISSAASVWLVM 397
Cdd:cd10329  312 TLVTELLPVGLRGLVLAVLLAALMSSLTSIFNSASTLFTMDIYKRL--RPEASEKELVRVGRIATLVVVVISILWAPIIQ 389
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446550739 398 ADESEIWDAFNSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGIIISVI---TVLGARYATDLNFFFYGVIGSL 467
Cdd:cd10329  390 AQGGSLFNYIQSVLSYLAPPIAAVFLLGIFWKRTNEQGAFWGLIAGLVlglVRLILEFAYGEPDTRPAIIGGI 462
SLC5sbd_SMVT cd11504
Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This ...
6-441 4.48e-32

Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This multivitamin transporter SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate, and is essential for mediating biotin uptake into mammalian cells. SMVT is expressed in the placenta, intestine, heart, brain, lung, liver, kidney and pancreas. Biotin may regulate its own cellular uptake through participation in holocarboxylase synthetase-dependent chromatin remodeling events at SMVT promoter loci. The cis regulatory elements, Kruppel-like factor 4 and activator protein-2, regulate the activity of the human SMVT promoter in the intestine. Glycosylation of the hSMVT is important for its transport function. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271394 [Multi-domain]  Cd Length: 527  Bit Score: 128.84  E-value: 4.48e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739   6 FGIVNYLVLFGYLLAMMLVGVYFS---RRQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAF---TSDWTFI 79
Cdd:cd11504    1 FHVADYVVFSLLLVISAGIGLYYActgGKQKTTREFLMADRKMGCLPVALSLLATFQSAVAILGGPSESYtfgTQYWFLG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  80 IGQYLAIAILPLVFyfyIPFFRKLKVTSAYEYLEARFDVRCRLFASMSFMLFHIGRIAIITFLTVLALRPFIAIDPVILV 159
Cdd:cd11504   81 CSYFLGLLIPAHVF---IPVFYRLELTSAYEYLELRFNKTVRICGTVTFIFQMVIYMGVVLYAPALALNAVTGFNLWISV 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 160 LLISVMCIIYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVICLKVqGGIGEIFTVTQQADK-----FFP-ATQFHWSWTe 233
Cdd:cd11504  158 LAMGVVCTFYTALGGLKAVIWTDVFQTVVMFAGQLAVIIVGSIEA-GGIARVWRVAAESDRidgfnLSPdPTIRHTFWT- 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 234 stvpvLMIGFLFANIQQFTASQDVVQRYIVTDSIEETKKTLLTNAKLVAVIPVFFFAIGSALFVYYQQHPQLLPAGFNTG 313
Cdd:cd11504  236 -----LVVGGVFNMLALYGVNQAQVQRYLSSRTEKQAKRSCYLVFPGQQLSLCIGCLCGLVMFARYHECDPLKNGIVARS 310
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 314 GILPLFVVTEMPVGIAGLIIAAIFAAAQSSISSSLNSisscFNSDIYQRLSHKKRTPENRMKIAKLVILVAGLISSAASV 393
Cdd:cd11504  311 DQLVPYFVMDVLDGLPGLPGLFIACLFSGALSTISSA----FNSLATVTMEDLIVPKFPDMTEERATLLSKGLAVGYGLL 386
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446550739 394 WLVMADES----EIWDAFNSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGII 441
Cdd:cd11504  387 CLLMAYLAstmgQVLQAANSIFGMIGGPLLGLFCLGMFFPCANSAGAVVGLL 438
SLC5sbd_u2 cd11478
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
9-485 1.82e-31

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271372  Cd Length: 496  Bit Score: 126.63  E-value: 1.82e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739   9 VNYLVLFGYLLAMMLVGVYFSRRQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAftSDWTFIIGQYLAIAI 88
Cdd:cd11478    1 VDYLIVAVYFVFVLGIGFYLKRKVKTSEDFFLSGRSLPAWITGLAFISANLGALEIVGMSANG--AQYGIATVHFYWIGA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  89 LP-LVF--YFYIPFFRKLKVTSAYEYLEARFDVRCRLFASMSFMLFHIGRIAIITFLTVLALRPFIAIDPVILVLLISVM 165
Cdd:cd11478   79 IPaMVFlgIVMMPFYYGSKVRSVPEYLKLRFNKSTRLLNAVSFAVMTILMSGINLYALALVLNVLLGWPLWLSIILSAAI 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 166 CIIYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVICLKVQGGIGEIFTVTQ-------QADKFFPATQFHWSWTESTVPV 238
Cdd:cd11478  159 VLAYTTLGGLTSAIYNEVLQFFLIVAGLIPLVIIGLIKVGGWDGLSEKIDAngppgwnGLSWGPQGSQSTNPMGVNLGLV 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 239 LMIGFLFANiQQFTASQDVVQRYIVTDSIEETKKTLLTNAKLVAVIPVFFFAIGSALFVYYQQHPQLLPAGFNTggILPL 318
Cdd:cd11478  239 FGLGFVLSF-GYWTTNFLEVQRAMAAKDLSAARRTPLIAAFPKMFIPFLVILPGLIALVLVPELGASGGLDYNQ--ALPY 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 319 FVVTEMPVGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLSHKKRTPENRMKIAKLVIlVAGLISSAASVWLVMA 398
Cdd:cd11478  316 LMAKYLPPGLLGLGITALLAAFMSGMAGNVSAFNTVFTYDIYQTYIVKDAPDKHYLKVGRIAT-VVGVLISIGTAYIASS 394
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 399 DESeIWDAFNSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGIII---SVITVLGARYATDLNFF------FYGVIGSLSV 469
Cdd:cd11478  395 FNN-IMDYLQLLFSFFNAPLFATFLLGMFWKRATPWGGFWGLLAgtaSAIVLYGLYELGLIVYHsdmapnFYGAWWAFVV 473
                        490
                 ....*....|....*.
gi 446550739 470 VISGVIFAPLFAPAPP 485
Cdd:cd11478  474 CFVVTVLVSLLTKPKP 489
SLC5sbd_SMCT1 cd11519
Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain; SMCT1 ...
5-489 1.95e-27

Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain; SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. Human SMCT1 (hSMCT1, also called AIT) is encoded by the tumor suppressor gene SLC5A8. Its expression is under the control of the C/EBP transcription factor. Its tumor-suppressive role is related to uptake of butyrate, propionate, and pyruvate, these latter are inhibitors of histone deacetylases. SMCT1 is expressed in the colon, small intestine, kidney, thyroid gland, retina, and brain. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs. SMCT1 also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and through transporting l-lactate and ketone bodies helps maintain the energy status and the function of neurons. In the kidney its expression is limited to the S3 segment of the proximal convoluted tubule (in contrast to the low-affinity monocarboxylate transporter SMCT2, belonging to a different family, which is expressed along the entire length of the tubule). In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner, SMCT1 is expressed predominantly in retinal neurons and in retinal pigmented epithelial (RPE) cells. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271402  Cd Length: 542  Bit Score: 115.33  E-value: 1.95e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739   5 SFGIVNYLVLFGYLLAMMLVGVYFS---RRQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAF---TSDWTF 78
Cdd:cd11519    3 TFSVWDYVVFAGMLLISAGIGIYYAfagGGQQTSKDFLMGGRQMTAVPVALSLTASFMSAVTVLGTPAEVYrfgAIFSIF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  79 IIGQYLAIAILPLVFyfyIPFFRKLKVTSAYEYLEARFDVRCRLFASMSFMLFHIGRIAIITFLTVLALRPFIAIDPVIL 158
Cdd:cd11519   83 AFTYAIVVVISAEVF---LPVFYRLGITSTYEYLELRFNKCVRLIGTSLFIVQTALYTGIVIYAPALALNQVTGFDLWGA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 159 VLLISVMCIIYTWMGGIEGVIWTDVIQ-GLLLSG-SAILIFIVIclkVQGGIGEIFTVTQQADK-----FFP-ATQFHWS 230
Cdd:cd11519  160 VVATGVVCTFYCTLGGLKAVIWTDVFQvGIMVAGfVSVIIRAVV---LQGGIGTILNDSYYGGRlnfwdFDPnPLQRHTF 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 231 WTestvpvLMIGFLFANIQQFTASQDVVQRYIVTDSIEETKKTLLTNAKLVAVIPVFFFAIGSALFVYYQQHPQLLPAGF 310
Cdd:cd11519  237 WT------IVIGGTFTWTSIYGVNQSQVQRYISCKTRFQAKMSLYVNLVGLWAILSCAVLSGLAMYSIYKDCDPWTAKDV 310
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 311 NTGGILPLFVVTE-------MPVGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLSHKKRTPENR---MKIAKLV 380
Cdd:cd11519  311 SAPDQLMPYLVLDiladypgLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSLSERQLSWISMgmsVFYGALC 390
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 381 ILVAGLISSAASvwlvmadeseIWDAFNSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGIIIsvitvlgaryatdlnfff 460
Cdd:cd11519  391 IGMAGLASLMGA----------LLQAALSIFGMVGGPLLGLFALGILFPFANSIGALVGLMS------------------ 442
                        490       500
                 ....*....|....*....|....*....
gi 446550739 461 yGVIGSLSVVISGVIFAPLFAPAPPLTLD 489
Cdd:cd11519  443 -GFAISLWVGIGAQIYPPLPEKTLPLPLS 470
SLC5sbd_SMCT cd11505
Na(+)/monocarboxylate cotransporters SMCT1 and 2 and related proteins; solute-binding domain; ...
5-489 6.33e-25

Na(+)/monocarboxylate cotransporters SMCT1 and 2 and related proteins; solute-binding domain; SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. Human SMCT1 (hSMCT1, also called AIT) is encoded by the tumor suppressor gene SLC5A8. SMCT1 is expressed in the colon, small intestine, kidney, thyroid gland, retina, and brain. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs. It also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and, through transporting L-lactate and ketone bodies, helps maintain the energy status and the function of neurons. SMCT2 is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. hSMCT2 is encoded by the SLC5A12 gene. SMCT2 is expressed in the kidney, small intestine, skeletal muscle, and retina. In the kidney, SMCT2 may initiate lactate absorption in the early parts of the tubule, SMCT1 in the latter parts of the tubule. In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271395  Cd Length: 538  Bit Score: 108.05  E-value: 6.33e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739   5 SFGIVNYLVLFGYLLAMMLVGVYFS---RRQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIIG 81
Cdd:cd11505    3 NFAVWDYVVFAAMLFISAGIGIYYAfagGGQATSKDFLMGGRQMTAVPVALSLTASFMSAVTVLGTPSEVYRFGASFLIF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  82 QYLAIAILPLVFYFYIPFFRKLKVTSAYEYLEARFDVRCRLFASMSFMLFHIGRIAIITFLTVLALRPFIAIDPVILVLL 161
Cdd:cd11505   83 AFAYLFVVLISSEVFLPVFYRLGITSTYEYLELRFNKPVRLAGTVLFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 162 ISVMCIIYTWMGGIEGVIWTDVIQ-GLLLSGsaILIFIVICLKVQGGIGEIFTVTQQADK-----FFP-ATQFHWSWTes 234
Cdd:cd11505  163 TGVVCTFYCTLGGLKAVVWTDVFQvGIMVAG--FLSVIIQAVVHQGGIHNILNDSYNGSRlnfwdFDPnPLRRHTFWT-- 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 235 tvpvLMIGFLFANIQQFTASQDVVQRYIVTDSIEETKKTLLTNakLVAVIPVFFFAIGSALFVYYQQH------------ 302
Cdd:cd11505  239 ----ITVGGTFTWTGIYGVNQSQVQRYISCKTRFQAKLSLYFN--LLGLWAILVCAVFSGLAMYSHYKdcdpwtakivsa 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 303 -PQLLPagfntggILPLFVVTEMPVGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDI---YQRLSHKKRTpenrmKIAK 378
Cdd:cd11505  313 pDQLMP-------YLVLDILADYPGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIkpyFRSLSEKLSS-----WISK 380
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 379 LVILVAGLI-SSAASVWLVMADeseIWDAFNSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGIIIsvitvlgaryatdln 457
Cdd:cd11505  381 GLSLLYGAMcIGMAVAASLMGG---LLQAALSIFGMVGGPLLGLFSLGILFPFVNSKGALGGLLT--------------- 442
                        490       500       510
                 ....*....|....*....|....*....|..
gi 446550739 458 fffyGVIGSLSVVISGVIFAPLFAPAPPLTLD 489
Cdd:cd11505  443 ----GFAISLWVGIGAQIYPPPPSKTLPLPLS 470
SLC5sbd_PutP cd11475
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli ...
11-464 1.42e-23

Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271369  Cd Length: 464  Bit Score: 103.36  E-value: 1.42e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  11 YLVLFGYLLAMMLVGVYFSRRQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIigqYLAIAILP 90
Cdd:cd11475    1 LITFIVYLLLMLGIGIYSYRKTKTLEDYFLGGRSLGPWVTALSAGASDMSGWLLLGLPGAAYASGLSAI---WIAIGLIL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  91 LVFYFYIPFFRKLKVTSAY-------EYLEARFDVRCRLFASmsfmlfhIGRIAIITFLTVLALRPFIA----------I 153
Cdd:cd11475   78 GAYLNWLFVAKRLRRYTEKndsitlpDYLENRFRDKSKLLRI-------LSALIILIFFTIYAAAQLVAggklfeslfgI 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 154 DPVILVLLISVMCIIYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVICLKVqGGIGEIFTVTQQADKFFpaTQFHWSWTE 233
Cdd:cd11475  151 DYSTGLLIGAVVVVAYTFLGGFLAVSWTDFFQGLLMLLALVLVPIVALAAL-GGLSGLVAALAAIDPGL--LSPFGGDLG 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 234 STVPVLMIGFLFANIQQFTASQDVVqRYIVTDSIEETKKtlltnAKLVAVIPVFFFAIGSAL-----FVYYQQHPqllpa 308
Cdd:cd11475  228 AGGLLAIISLLAWGLGYFGQPHILV-RFMAIRSPKEIKK-----ARRIAMVWMILFLLGAVLvgllgRALFPDGL----- 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 309 GFNTGGILPLFVVTEMPVGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLSHKKRTPENRMKIAKLVILVAGLIs 388
Cdd:cd11475  297 LGDPETVFPVLAQELFPPWLAGILLAAILAAIMSTADSQLLVCSSALTEDLYKAFLRKEASDKELVWVSRLAVLVIALI- 375
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 389 saaSVWLVMADESEIWD----AFnSLIGLMGGPmtgLFMLGIFFKRANAGSAVLGIIISVITVLGARYATDLNFFFYGVI 464
Cdd:cd11475  376 ---ALLIALNPPSSVFSlvsfAW-AGLGAAFGP---LLLLSLYWKRTTRQGALAGMIAGAVTVVVWKLLGLGIFGLYEIV 448
SLC5sbd_NIS cd11503
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of ...
9-299 2.85e-21

Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. NIS is expressed in the thyroid, colon, ovary, and in human breast cancers. It mediates the active transport and the concentration of iodide from the blood into thyroid follicular cells, a fundamental step in thyroid hormone biosynthesis, and is the basis of radioiodine therapy for thyroid cancer. Mutation in the SLC5A5 gene can result in a form of thyroid hormone dysgenesis. Human NIS exists mainly as a dimer stabilized by a disulfide bridge. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271393  Cd Length: 535  Bit Score: 96.84  E-value: 2.85e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739   9 VNYLVLFGYLLAMMLVGVYFSRR---QKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFI---IGQ 82
Cdd:cd11503    1 WDYGVFAAMLLVSTGIGLFVGLArggQRSADDFFTGGRGLSAVPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLwmcLGQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  83 YLAIAILPLVFyfyIPFFRKLKVTSAYEYLEARFDVRCRLFASMSFMLFHIGRIAIITFLTVLALRPFIAIDPVILVLLI 162
Cdd:cd11503   81 LLNSLMTAVLF---MPVFYRLGITSTYQYLEMRFSRAVRLCGTLQFIVATMLYTGIVIYAPALILNQVTGLDIWASLFST 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 163 SVMCIIYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVICLKVqGGIGEIFTVTQQADK-----FFPATQFHWS-WTestv 236
Cdd:cd11503  158 GIICTFYTTVGGMKAVIWTDVFQVVVMLSGFWAVLIRGVILV-GGPRRVLEIAQNHSRinfmdFDPDPRRRYTfWT---- 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446550739 237 pvLMIGFLFANIQQFTASQDVVQRYIVTDSIEETKKTLLTNAKLVAVIPVFFFAIGSALFVYY 299
Cdd:cd11503  233 --FVVGGTLVWLSMYGVNQAQVQRYVACRTEKQAKLALLVNQVGLCLIVSSAATCGIVMFVYY 293
PRK10484 PRK10484
putative transporter; Provisional
12-477 1.55e-17

putative transporter; Provisional


Pssm-ID: 236699 [Multi-domain]  Cd Length: 523  Bit Score: 85.32  E-value: 1.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  12 LVLFGYLLAMMLVGV---YFSRRQK--TADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSdwTFIIGQYLAI 86
Cdd:PRK10484   2 LTILSFLGFTLLVAViswWKTRKTDtsSSDGYFLAGRSLTGPVIAGSLLLTNLSTEQLVGLNGQAYAS--GMSVMAWEVT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  87 AILPLVF--YFYIPFFRKLKVTSAYEYLEARFDVRCRLFASMSFMLFHI----------GRIA---IITFLTVLALRPFI 151
Cdd:PRK10484  80 AAIALIIlaLIFLPRYLKSGITTIPDFLEERYDKTTRRIVSILFLIGYVvsflpivlysGALAlnsLFHVSELLGISYGA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 152 AIdpVILVLLISVMCIIYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVICLKV-QGGIGEIFT--VTQQADKF----FPA 224
Cdd:PRK10484 160 AI--WLLVWLIGIIGAIYAVFGGLKAVAVSDTINGIGLLIGGLLVPVFGLIALgDGSFMQGLEqlTTVHPEKLnsigGAT 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 225 TQFHWswtestvPVLMIGFLFANIQQFTASQDVVQRYIVTDSIEETKKTLLTNAKLVAVIPVFFFAIGSALFVYYQqhPQ 304
Cdd:PRK10484 238 DPVPF-------PTLFTGLILVNLFYWCTNQSIVQRALGAKNLAEGQKGALLAAFFKLLGPLILVLPGIIAFHLYG--DG 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 305 LLPAGFntggILPLFVVTEMPVGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLSHKKRTPENRMKIAKLVILVA 384
Cdd:PRK10484 309 LPNADM----AYPTLVNDVLPVPLVGFFAAVLFGAILSTFNGFLNSASTLFSLDIYKPIINPNASEKQLVKVGKKFGFVL 384
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 385 GLISSAASVWLVMADESeIWDAFNSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGIIISVITVLGARYATDLNFFFYGVI 464
Cdd:PRK10484 385 AIISMIVAPLIANAPQG-LYSYLQQLNGIYNVPILAIIIVGFFTKRVPALAAKVALGFGIILYIIINFVLKFDIHFLYVL 463
                        490
                 ....*....|...
gi 446550739 465 GSLSVVISGVIFA 477
Cdd:PRK10484 464 AILFVINVVVMLI 476
SLC5sbd_vSGLT cd10325
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute ...
12-444 2.82e-17

Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; vSGLT transports D-galactose, D-glucose, and alpha-D-fucose, with a sugar specificity in the order of D-galactose >D-fucose >D-glucose. It transports one Na+ ion for each sugar molecule, and appears to function as a monomer. vSGLT has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271360  Cd Length: 523  Bit Score: 84.28  E-value: 2.82e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  12 LVLFGYLLAMMLVGVYFSR----RQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFtsDWTFIIGQYLAIA 87
Cdd:cd10325    1 VIFIVYVILIIGLGLWVSRekkgGEKDATDYFLAGKSLPWWAIGASLIAANISAEQFIGMSGSGF--AIGLAIASYEWMA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  88 ILPLVF--YFYIPFFRKLKVTSAYEYLEARFDVRCRLFASMSFMLFHIG-RIAIITFLTVLALRPFIAIDPVILVLLISV 164
Cdd:cd10325   79 AITLIIvaKFFLPIFLKNGIYTMPQFLEERYDGRVRTIMAVFWLLLYVFvNLTSVLYLGALAIETITGIPLTYSIIGLAL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 165 MCIIYTWMGGIEGVIWTDVIQGLLLSGSAiLIFIVICLKVQGGIGEIFTVTQQADKFFPA------TQFHWSWTESTVP- 237
Cdd:cd10325  159 FAAAYSIYGGLKAVAWTDVIQVVFLVLGG-LVTTYIALSLLGGGEGVFAGFTLLAAEAPEhfhmilDKSNPEDAYKDLPg 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 238 --VLMIGFLFANIQQFTASQDVVQRYIVTDSIEETKKTLLTNAKLVAVIPVFFFAIGSALFVYYQ-QHPQLLPAGFNTGG 314
Cdd:cd10325  238 iaVLLGGLWVANLSYWGFNQYIIQRALAAKSLSEAQKGIVFAAFLKLLIPFIVVIPGIAAYVLASnLLLPAATGIEKPDQ 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 315 ILPlFVVTEMPVGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLSHKKRTPENRMKIAKLVILVAGLIssAASVW 394
Cdd:cd10325  318 AYP-WLLRNLPTGLKGLVFAALTAAIVSSLASMLNSISTIFTMDIYKKYIPKKASEKQLVNVGRLAAVIALII--AALIA 394
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 446550739 395 LVMADESEIWDAFNSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGIIISV 444
Cdd:cd10325  395 PPLLGLDQAFQYIQEYTGFISPGILAIFLLGLFWKRATSAGALVAAILSI 444
SSF pfam00474
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ...
38-442 8.34e-17

Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.


Pssm-ID: 109527 [Multi-domain]  Cd Length: 406  Bit Score: 82.39  E-value: 8.34e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739   38 YFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIIGQYLAIAILPLVFYFYIPFFRKLKVTSAYEYLEARFD 117
Cdd:pfam00474   1 YFLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAASGLAGGLYAIGALVGVWLLLWLFAPRLRNLGAYTMPDYLRKRFG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  118 VR--CRLFASMSFMLFHIGRIAIITFLTVLALRPFIAIDPVILVLLISVMCIIYTWMGGIEGVIWTDVIQGLLLSGSAIL 195
Cdd:pfam00474  81 GKriLVYLSALSLLLYFFTYMSVQIVGGARLIELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVLMLFGTII 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  196 IFIVICLKVqGGIGEIF----TVTQQADKFFPATQFHWSWTESTVPVLMIGFLFANIQQftasQDVVQRYIVTDSIEETK 271
Cdd:pfam00474 161 LMIIVFHEV-GGYSSAVekymTADPNGVDLYTPDGLHILRDPLTGLSLWPGLVLGTTGL----PHILQRCLAAKDAKCIR 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  272 KTLLTNAKLVAVIPVFFFAIGSALFVYYQQHPQLlpAGFNTGG---ILPLFVVTEMPVGIAGLIIAAIFAAAQSSISSSL 348
Cdd:pfam00474 236 CGVLILTPMFIIVMPGMISRGLFAIALAGANPRA--CGTVVGCsniAYPTLAVKLGPPGLAGIMLAVMLAAIMSTLTSQL 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  349 NSISSCFNSDIYQRLshKKRTPENRMKIAKLVILVAGLISSAASVWLVMADESEIWDAFNSLIGLMGGPMTGLFMLGIFF 428
Cdd:pfam00474 314 LSSSSAFTHDLYKNI--RRKASATEKELVGRSRIIVLVVISLAILLAVQPAQMGIAFLVQLAFAGLGSAFLPVILLAIFW 391
                         410
                  ....*....|....
gi 446550739  429 KRANAGSAVLGIII 442
Cdd:pfam00474 392 KRVNEQGALWGMII 405
SLC5sbd_SMCT2 cd11520
Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain; SMCT2 ...
6-444 8.57e-16

Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain; SMCT2 is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. Human SMCT2 (hSMCT2) is encoded by the SLC5A12 gene. SMCT2 is expressed in the kidney, small intestine, skeletal muscle, and retina. In the kidney, it is expressed in the apical membrane of the proximal convoluted tubule, along the entire length of the tubule (in contrast to the high-affinity monocarboxylate transporter SMCT1, belonging to a different family, which is limited to the S3 segment of the tubule). SMCT2 may initiate lactate absorption in the early parts of the tubule. In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner, SMCT2 is expressed exclusively in Muller cells. Nicotine transport by hSMCT2 is inhibited by several non-steroidal anti-inflammatory drugs. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212089 [Multi-domain]  Cd Length: 529  Bit Score: 79.89  E-value: 8.57e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739   6 FGIVNYLVLFGYLLAMMLVGVYFS---RRQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIIGQ 82
Cdd:cd11520    4 FVAWDYVVFAGLFLVSSGIGVFFAikeRKKATSKEFLVGGRQMSCGPVALSLTASFMSAVTVLGTPAEVYRFGASFVLFF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  83 YLAIAILPLVFYFYIPFFRKLKVTSAYEYLEARFDVRCRLFASMSFMLFHIGRIAIITFLTVLALRPFIAIDPVILVLLI 162
Cdd:cd11520   84 IAYTFVIIFTSELFLPVFYRSGITSTYEYLELRFNKPVRYAATLIYIVQTILYTGVVVYAPALALNQVTGFDLWGSVFAT 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 163 SVMCIIYTWMGGIEGVIWTDVIQGLLLsgsaILIFIVICLKVQGGIGEIFTVTQQA---------DKFFPATQFHWSWTe 233
Cdd:cd11520  164 GIVCTFYCTLGGLKAVVWTDAFQMVVM----VVGFLTVLIQGSIHNGGFTNVWETAyngsrlnifDFDVDPLRRHTFWT- 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 234 stvpvLMIGFLFANIQQFTASQDVVQRYIVTDSIEETKKTLLTNakLVAVIPVFFFAIGSALFVY-YQQHPQLLPAGFNT 312
Cdd:cd11520  239 -----ITVGGTFTWLGIYGVNQSTIQRCISCKTEKHAKLALYLN--LLGLWIILVCAVFSGLIMYsHYKDCDPWTSGFIS 311
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 313 G--GILPLFVVT------EMPVGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLSHKKRTpenrmKIAK-LVILV 383
Cdd:cd11520  312 ApdQLMPYFVMEifstmpGLPGLFVACAFSGTLSTVAASINALATVTFEDFVKSCFPHLSEKLST-----WISKgLCILF 386
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446550739 384 AGLISSAASVWLVMADeseIWDAFNSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGIIISV 444
Cdd:cd11520  387 GVMCTSMAVAASLMGG---VVQAALSIHGMCGGPMLGLFTLGIVFPFVNWKGALGGLLTGI 444
SLC5sbd_SGLT1 cd11486
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ...
13-449 2.00e-15

Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.


Pssm-ID: 271379  Cd Length: 636  Bit Score: 78.82  E-value: 2.00e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  13 VLFGYLLAMMLVGVY--FSRRQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIIGQYLAIAILP 90
Cdd:cd11486    5 VIVIYFVVVLAVGVWamVSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGIAGTGAAAGIAIGGFEWNALVVVV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  91 LVFYFYIPFFRKLKVTSAYEYLEARFD-VRCRLFAS-MSFMLFHIGRIAIITFLTVLALRPFIAIDPVILVLLISVMCII 168
Cdd:cd11486   85 VLGWLFVPIYIKAGVVTMPEYLRKRFGgQRIQVYLSvLSLCLYIFTKISADIFSGAIFINLALGLNLYLAIVILLAITAL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 169 YTWMGGIEGVIWTDVIQG-LLLSGSAILI-----------------FIVICLKVQGGIGEIFT--VTQQADKFF----PA 224
Cdd:cd11486  165 YTITGGLAAVIYTDTLQTiIMVVGSFILMgfafnevggydafmekyMTAIPSVIGTGNSTSQEkcYTPRADSFHifrdPI 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 225 T-QFHWswtestvPVLMIGFLFANIQQFTASQDVVQRYIVTDSIEETKKTLLTNAKLvAVIPVFFFAIGSAL--FVYYQQ 301
Cdd:cd11486  245 TgDLPW-------PGLLFGLSILTLWYWCTDQVIVQRCLSAKNMSHVKAGCILCGYL-KLLPMFIMVMPGMIsrILYTDE 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 302 HPQLLPA------GFNTGGI---LPLFVVTEMPVGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLshKKRTPEN 372
Cdd:cd11486  317 IACVVPDeckavcGTEVGCTniaYPKLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYTKV--RKKASEK 394
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446550739 373 RMKIA-KLVILVAGLISSAASVWLVMADESEIWDAFNSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGIIISVITVLG 449
Cdd:cd11486  395 ELMIAgRLFMLVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEPGAFWGLCVGLLVGLA 472
PanF COG4145
Na+/panthothenate symporter [Coenzyme transport and metabolism];
11-476 4.87e-15

Na+/panthothenate symporter [Coenzyme transport and metabolism];


Pssm-ID: 443316  Cd Length: 484  Bit Score: 77.19  E-value: 4.87e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  11 YLVLFGYLLAMMLVGVYFSRR---QKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTS--DWTFIIGQYLA 85
Cdd:COG4145    7 LIPLLIYLLLVLGIGIYASRKrskGSFLEEYFLGSRSMGGFVLAMTLAATYTSASSFIGGPGAAYKYglGWVLLAMIQVP 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  86 IAILPLVFY---FYIpFFRKLKVTSAYEYLEARFDVR-CRLFASMSFMLFHIGRI-AIITFLTVLaLRPFIAIDPVILVL 160
Cdd:COG4145   87 TAFLTLGVLgkkFAI-LGRKYNAVTLADWLRARYQSKaLVLLAALLLLLFFIAFMvAQFVGGARL-LETVTGISYTTGLL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 161 LISVMCIIYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVIcLKVQGGIGEIFTVTQQAD----KFFPATQFHwswtesTV 236
Cdd:COG4145  165 IFGVTVVLYTTIGGFRAVVLTDAIQGIIMLVGTVLLLIGV-ISAGGGIENIMSTLAAIDpnlvSPTGPDGFL------PR 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 237 PVLMIGFLFANIQQFTASQDVVQRYIVTDSieetkKTlLTNAKLVAVIPVFFFAIGSALFVYYQQhpQLLPAGFNTGGIL 316
Cdd:COG4145  238 PFVISFWILVGFGVIGLPHTAVRCMAYKDS-----KS-LHRAMIIGTIVVGLLMFGMHLIGVLGR--AVLPDLTVPDQVI 309
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 317 PLFVVTEMPVGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLSHKKRTPENR--MKIAKLVILVAGLISSAASvw 394
Cdd:COG4145  310 PTLMVKVLPPFLAGIFLAGPLAAIMSTVDSLLLQASSTIVKDLYLNYINPKASENEKklKRLSKLVTLVLGLIVFLLA-- 387
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 395 lVMADESEIWDAFNSLiglmGGPMTGLFM---LGIFFKRANAGSAVLGIIISVITVLGARYatdLNFFFYGVIGSL-SVV 470
Cdd:COG4145  388 -LNPPDLIIWLNLFAF----GGLEAAFFWplvLGLYWKRANATGAIASMLVGVASYFLLYY---GNPKIFGFHAIVpSLL 459

                 ....*.
gi 446550739 471 ISGVIF 476
Cdd:COG4145  460 ISLIAF 465
SLC5sbd_SGLT4 cd11488
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 ...
13-445 4.32e-14

Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 (hSGLT4) has been reported to be a low-affinity glucose transporter with unusual sugar selectivity: it transports D-mannose but not galactose or 3-O-methyl-D-glucoside. It is encoded by the SLC5A9 gene and is expressed in intestine, kidney, liver, brain, lung, trachea, uterus, and pancreas. hSLGT4 is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5 )transporter family.


Pssm-ID: 271380  Cd Length: 605  Bit Score: 74.59  E-value: 4.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  13 VLFGYLLAMMLVGVYFSRR--QKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIIGQYLAIAILP 90
Cdd:cd11488    4 VVVVYFVFVLAVGIWSSIRasRGTVGGYFLAGRSMTWWPIGASLMSSNVGSGLFIGLAGTGAAGGLAVGGFEWNAAWVLI 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  91 LVFYFYIPFFRKLKVTSAYEYLEARFD-VRCRLFAS-MSFMLFHIGRIAIITFLTVLALRPFIAIDPVILVLLISVMCII 168
Cdd:cd11488   84 ALGWIFVPVYIAAGVVTMPEYLKKRFGgQRIRIYMSvLSLILYIFTKISTDIFSGALFIQVSLGWNLYLSTVILLAVTAL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 169 YTWMGGIEGVIWTDVIQGLLLSGSAILIFIVICLKVQGGIGEIFTVTQQADKF-FPATQFHWSWTES------------T 235
Cdd:cd11488  164 YTIAGGLTAVIYTDALQTVIMVIGAFVLMFIAFDKVGWYPGLEQQYEKAIPALtVPNTTCHLPRSDAfhifrdpvtgdiP 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 236 VPVLMIGFLFANIQQFTASQDVVQRYIVTDSIEETKKTLLTNAKLvAVIPVFFFA----IGSALF------VYYQQHPQL 305
Cdd:cd11488  244 WPGLIFGLTVLATWVWCTDQVIVQRSLSAKNLSHAKGGSVLGGYL-KILPMFFVVmpgmISRALFpdevgcVDPDECQKI 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 306 LPAGFNTGGI-LPLFVVTEMPVGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLsHKKRTPENRMKIAKLVILVA 384
Cdd:cd11488  323 CGAKVGCSNIaYPKLVVELMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTMDVWQRI-RRRASEQELMVVGRVFILLL 401
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446550739 385 GLISSAASVWLVMADESEIWDAFNSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGIIISVI 445
Cdd:cd11488  402 VVISILWIPIIQTANSGQLFDYIQAVTSYLSPPITAVFILAIFWKRVNEPGAFWGLMVGLV 462
SLC5sbd_YidK cd10328
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; ...
17-477 6.62e-14

uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Uncharacterized subfamily of the solute binding domain of the solute carrier 5 (SLC5) transporter family (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily includes the uncharacterized Escherichia coli YidK protein, and belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271362  Cd Length: 472  Bit Score: 73.72  E-value: 6.62e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  17 YLLAMMLVGVYF-----SRRQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIIGQYLAIAILPL 91
Cdd:cd10328    1 FLLFTALVALISwyktrGDDLSSSDGYFLAGRSLTGVVIAGSLLLTNLSTEQLVGLNGQAYALGMSVMAWEVTAAIALII 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  92 VFYFYIPFFRKLKVTSAYEYLEARFDVRCRLFASMSFMLFHI----------GRIAIITFL---TVLALRPFIAIdpVIL 158
Cdd:cd10328   81 LALVFLPRYLKGGITTIPEFLEERYDETTRRIVSILFLLGYVvillpivlysGALALNSLFdvsELLGISYFQAL--WLL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 159 VLLISVMCIIYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVICLKVQGG--IGEIFTVTQQADKFFPAtqfhWSWTESTV 236
Cdd:cd10328  159 VWLIGIIGAIYAIFGGLKAVAVSDTINGVGLLIGGLLIPILGLIALGDGsfLAGLDTLLTAHPEKLNA----IGGADSPV 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 237 P--VLMIGFLFANIQQFTASQDVVQRYIVTDSIEETKKTLLTNAKLVAVIPVFFFAIGSALFVYYQqhpqllPAGFNTGG 314
Cdd:cd10328  235 PfsTLFTGMLLVNLFYWCTNQAIIQRALAAKNLKEGQKGVLLAGFFKLLVPLILVLPGIIAFHLYG------DGLENADM 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 315 ILPLFVVTEMPVGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLSHKKRTPENRMKIAKLVILVAGLISSAASVW 394
Cdd:cd10328  309 AYPTLVADVLPKWLSGFFAAVLFGAILSSFNSALNSAATLFSLDIYKPIINKNATDKQLVKVGKIFGIVLALISMIIAPF 388
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 395 LVMADESeIWDAFNSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGIIISVITVLGARYATDLNFFFYGVIGSLSVVISGV 474
Cdd:cd10328  389 IAYAPEG-LFNYLQQFNGFFSIPILAIVLVGFFTKRVPALAAKIALIFGVILYALLQFVFLVPIHFLHVLAILFVICVAI 467

                 ...
gi 446550739 475 IFA 477
Cdd:cd10328  468 MLI 470
SLC5sbd_SGLT2 cd11487
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 ...
12-441 8.63e-12

Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 (hSGLT2) is a high-capacity, low-affinity glucose transporter, that plays an important role in renal glucose reabsorption. It is encoded by the SLC5A2 gene and expressed almost exclusively in renal proximal tubule cells. Mutations in hSGLT2 cause Familial Renal Glucosuria (FRG), a rare autosomal defect in glucose transport. hSGLT2 is a major drug target for regulating blood glucose levels in diabetes. hSGLT2 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212056 [Multi-domain]  Cd Length: 583  Bit Score: 67.25  E-value: 8.63e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  12 LVLFGYLLAMMLVGVYFSRR--QKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIIGQYLAIAIL 89
Cdd:cd11487    4 SVIAAYFLLVIGVGLWSMCRtnRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGIAVAGFEWNALFVV 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  90 PLVFYFYIPFFRKLKVTSAYEYLEARFD-VRCRLFAS-MSFMLFHIGRIAIITFLTVLALRPFIAIDPVILVLLISVMCI 167
Cdd:cd11487   84 LLLGWLFVPVYLTAGVITMPQYLKKRFGgQRIRLYLSvLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITM 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 168 IYTWMGGIEGVIWTDVIQGLLLSGSAiLIFIVICLKVQGGIGEIF-----TVTQQADKFFPA----TQFHWSWTESTV-- 236
Cdd:cd11487  164 IYTVTGGLAALMYTDTVQTFVIIGGA-CVLMGYAFHEVGGYSALFekylkAVPSLTVSEDPAvgniSSSCYRPRPDSYhl 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 237 -----------PVLMIGFLFANIQQFTASQDVVQRYIVTDSIEETKKTLLTNAKLvAVIPVFFFAIGSAL--FVYYQQHP 303
Cdd:cd11487  243 lrdpvtgdlpwPALILGLTIVSSWYWCSDQVIVQRCLAARSLTHVKAGCILCGYL-KLLPMFLMVMPGMIsrVLYPDEVA 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 304 QLLPA------GFNTGG---ILPLFVVTEMPVGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLSHKKRTPEnRM 374
Cdd:cd11487  322 CVEPSvclrvcGTEVGCsniAYPKLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIWTRLRPQAGDKE-LL 400
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446550739 375 KIAKLVILVAGLISSAASVWLVMADESEIWDAFNSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGII 441
Cdd:cd11487  401 LVGRVWVVCIVAVSVAWIPVVQAAQGGQLFDYIQSVSSYLAPPIAAVFFLALFVKRVNEPGAFWGLI 467
SLC5sbd_SGLT5 cd11489
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is ...
8-445 9.06e-12

Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is a glucose transporter, which also transports galactose. It is encoded by the SLC5A10 gene, and is exclusively expressed in the renal cortex. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212058  Cd Length: 604  Bit Score: 67.27  E-value: 9.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739   8 IVNYLVLFGYLLAMMLVGVYFSRR--QKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIIGQYLA 85
Cdd:cd11489    2 VADIIVIGVYFALNVAVGIWSSCRvsRNTVSGYFLAGRDMAWWPIGASLFASSEGSGLFIGLAGTGAAGGIAVAGFEWNA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  86 IAILPLVFYFYIPFFRKLKVTSAYEYLEARFD-VRCRLFAS-MSFMLFHIGRIAIITFLTVLALRPFIAIDPVILVLLIS 163
Cdd:cd11489   82 TYALLALAWVFVPVYISSGIVTMPEYLQRRFGgERIRMYLSvLSLLLSVFTKISTDLYSGALFVQVCLGWNLYLSTVLML 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 164 VMCIIYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVICLKVqGGIGEIFTVTQQA--DKFFPATQFHWSWTEST------ 235
Cdd:cd11489  162 VVTALYTIAGGLAAVIYTDALQTLIMVIGAVILTIKAFNQI-GGYSNLEEAYLQAvpSKIIPNTTCHLPRADAMhlfrdp 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 236 ------VPVLMIGFLFANIQQFTASQDVVQRYIVTDSIEETKKTLLTnAKLVAVIPVFFF----AIGSALF------VYY 299
Cdd:cd11489  241 vtgdlpWTGMTFGLTIMATWYWCTDQVIVQRSLSARSLSHAKGGSIL-ASYLKMLPMGLIimpgMISRALFpddvacVDP 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 300 QQHPQLLPAGFNTGGI-LPLFVVTEMPVGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLSHKKRTPENRMkIAK 378
Cdd:cd11489  320 EECLRVCGAEVGCSNIaYPKLVMELMPSGLRGLMIAVMMAALMSSLTSIFNSSSTLFTMDIWRRLRPGASERELLL-VGR 398
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446550739 379 LVILVAGLISSAASVWLVMADESEIWDAFNSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGIIISVI 445
Cdd:cd11489  399 LVTVILVGVSVVWIPILQSSNSGQLYIYIQSVTSYLAPPVTAVFVLAVFWRRANEQGAFWGLMAGLV 465
SLC5sbd_u3 cd11479
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
9-471 1.39e-10

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271373  Cd Length: 454  Bit Score: 63.39  E-value: 1.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739   9 VNYLVLFGYLLAMMLVGVYFSRRQKTADDYFRGGGRVPGWAAGVSVFATTL---SSITFMSIPAKAFTSDWTFIIGQYLA 85
Cdd:cd11479    1 LDYGVIALYFAAMIAIGWWGMRRAKTSEDYLVAGRRLGPGLYLGTMAAVVLggaSTIGGVGLGYQYGISGMWLVVAIGLG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  86 IAILPLVFYFYIpffRKLKVTSAYEYLEARFDVRCRLFASM-----SFMLFHIGRIAIITFLTVLAlrpfiAIDPVILVL 160
Cdd:cd11479   81 ILALSLLLAKRI---ARLKVYTVSEVLELRYGPSARVISALvmlayTLMVAVTSTIAIGTVFSVLF-----GLPRTLSIL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 161 LISVMCIIYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVICLKVQGGIGEIftVTQQADKFFPATQFHWswtESTVPVLM 240
Cdd:cd11479  153 VGGGIVVLYSVLGGMWSITLTDIIQFVIKTIGIFLLLLPLALSKAGGLSGL--QEKLPASYFDLTSIGW---DTIVTYFL 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 241 IGFLFANIqqftaSQDVVQRYIVTDSIEETKKTLLTNAKLVAVIPVFFFAIGSALFVyyqqhpqLLPAGFNTGGILPLFV 320
Cdd:cd11479  228 LYFFGILI-----GQDIWQRVFTARSEKVARWGGVAAGLYCVLYGVAGALIGMAAAV-------LLPDLANPQNAFATMA 295
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 321 VTEMPVGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLSHKKRTPENRMKIAKLVILVAGLISSAASVWL--VMA 398
Cdd:cd11479  296 QEVLPVGLRGLVLAAALAAMMSTASGALLASSTVLTNDVLPRLRRKNESERSEVRLSRLFTLLLGVVVIVIAVLVndVVA 375
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446550739 399 desEIWDAFNSLIGLMGGPMTGlfmlGIFFKRANAGSAVLGIIISVITVLG--ARYATDLNF-FFYGVIGSLSVVI 471
Cdd:cd11479  376 ---ALTIAYAILVGGLLVPILG----GLFWKRATGAGALASMVAGSVVVLAgmAVDGLLANTpIYYGLAVSLVAFV 444
SLC5sbd_SGLT6 cd11490
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human ...
13-445 1.61e-10

Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human SGLT6 (also called KST1, SMIT2) is a chiro-inositol transporter, which also transports myo-inositol. It is encoded by the SLC5A11 gene. Xenopus Na1-glucose cotransporter type 1 (SGLT-1)-like protein is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271381  Cd Length: 602  Bit Score: 63.39  E-value: 1.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  13 VLFGYLLAMMLVGVYFSRRQK--TADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIIGQYLAIAILP 90
Cdd:cd11490    4 VLVLYFLFVLAVGLWSMWKTKrsTVKGYFLAGKDMTWWPVGASLFASNVGSGHFIGLAGSGAAAGIGVVAYEWNGLFMVL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  91 LVFYFYIPFFRKLKVTSAYEYLEARFD-VRCRLFASMSFMLFHI-GRIAIITFLTVLALRPFIAIDPVILVLLISVMCII 168
Cdd:cd11490   84 VLAWLFLPIYIASRVTTMPEYLKKRFGgKRIQIFLAVLYLFIYIfTKISVDMYAGAVFIQQALQWDLYLAVVGLLGITAL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 169 YTWMGGIEGVIWTDVIQGLLLSGSAiLIFIVICLKVQGGIGEIftvtqqADKFFPAT----------------QFHWSWT 232
Cdd:cd11490  164 YTVAGGLAAVIYTDALQTIIMVIGA-LILMGYSFAEVGGFEAL------LEKYFQAIpsirspnstcgipredAFHIFRD 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 233 ESTV----PVLMIGFLFANIQQFTASQDVVQRYIVTDSIEETKKTLLTNAKLvAVIPVFFFAIGSAL--FVYYQQ----H 302
Cdd:cd11490  237 PVTSdlpwPGVLLGMSIPSLWYWCTDQVIVQRSLAAKNLSHAKGGSLLAAYL-KVLPLFMMVIPGMIsrILFPDQvacaD 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 303 PQLL------PAGFNTGGiLPLFVVTEMPVGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLSHkkRTPENRMKI 376
Cdd:cd11490  316 PEVCkeicgnPSGCSDIA-YPKLVMELLPTGLRGLMMAVMLAALMSSLTSIFNSASTIFTMDLWRHIRP--RASEWELMI 392
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 377 AKLVILVAGLISSAASVWLVMADE-SEIWDAFNSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGIIISVI 445
Cdd:cd11490  393 VGRVFVLVLVVVSILWIPLVQASQgGQLFIYIQSISSYLQPPVAVVFIAGCFWKRTNEKGAFWGLMVGLA 462
SLC5sbd_CHT cd11474
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ...
17-325 1.17e-09

Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271368 [Multi-domain]  Cd Length: 464  Bit Score: 60.23  E-value: 1.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  17 YLLAMMLVGVYFSRRQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIIGQYLAIAI-LPLVFYF 95
Cdd:cd11474    7 YYLLILGIGLWASRRVKSSEDFLLAGRSLPLPVGVFTLFATWFGGETILGAAETFYEEGLGGVAQDPFGYALcLILGGLF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  96 YIPFFRKLKVTSAYEYLEARFDVRCRLFASMSFMLFHIGRIA--IITFLTVLALrpFIAIDPVILVLLISVMCIIYTWMG 173
Cdd:cd11474   87 FAKPMRRMGLLTLGDFFRQRYGRRVEVLLSIPAVLSYLGWVAaqLVALGLVLSV--ILGLPVETGILISAAIVLAYTLFG 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 174 GIEGVIWTDVIQ-GLLLSGSAILIFIVICLkvQGGIGEIFTVTQQADKFFPATQFHWSWTESTVPVLMIGflFANIQQft 252
Cdd:cd11474  165 GMWSVAYTDVVQlIVIFVGLLVLVPFVLTN--PGGVDIASAAAAGKLRFFPWLGTKSDWLIWIDAWLTLG--LGSIPQ-- 238
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446550739 253 asQDVVQRYIVTDSIEETKKTLLTNAK---LVAVIPVFFFAIGSALFvyyqqhPQLLPAG--FNTGGILPLFVVTEMP 325
Cdd:cd11474  239 --QDVFQRVLSAKSEKTAQRLSLLAGVgylLFAIPPLLIGLAAASID------PSLTQYGleEDAQLILPLLLQYLTP 308
SLC5sbd_PanF cd10327
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute ...
12-211 3.10e-08

Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; PanF catalyzes the Na+-coupled uptake of extracellular pantothenate for coenzyme A biosynthesis in cells. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212037  Cd Length: 472  Bit Score: 56.06  E-value: 3.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  12 LVLFGYLLAMMLVGVYFSRRQKTAD-----DYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIigqYLAI 86
Cdd:cd10327    3 LPIIIYLVILLGIGFYARRSKKRRSgdfleEYFIGGRSMGGFVLAMTLVATYTSASSFIGGPGAAYKIGLGWV---LLAM 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  87 AILPLVFY--------FYIpFFRKLKVTSAYEYLEARFDvrcrlfasmSFMLFHIGRIAIITFLTVLALRPFIA------ 152
Cdd:cd10327   80 IQVPTGFLtlgvlgkkFAI-IARKINAVTIIDYLRARYN---------SKALVVLSSLALIVFFIAAMVAQFIGgarlle 149
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446550739 153 ----IDPVILVLLISVMCIIYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVIcLKVQGGIGEI 211
Cdd:cd10327  150 avtgLSYVTGLLIFGLTVILYTTIGGFRAVALTDAIQGIVMIIGTVLLLVGV-LAAGGGMEAI 211
SLC5sbd_SMIT cd11491
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT ...
12-446 6.33e-08

Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT is a high-affinity myo-inositol transporter, and is expressed in brain, heart, kidney, and lung. Inhibition of myo-inositol uptake, through down-regulation of SMIT, may be a common mechanism of action of mood stabilizers, including lithium, carbamazepine, and valproate. SMIT is encoded by the SLC5A3 gene, which is a candidate gene for pathogenesis of nervous system dysfunction in Down syndrome (DS). The SNP, 21q22 near SLC5A3-MRPS6-KCNE2, has been associated with coronary heart disease, cardiovascular disease, and myocardial infarction. SMIT may also be involved in the pathogeneisis of congenital cataract. SMIT also plays roles in osteogenesis, bone formation, and bone mineral density determination. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271382  Cd Length: 609  Bit Score: 55.26  E-value: 6.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  12 LVLFGYLLAMMLVGVY--FSRRQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIIGQYLAIAIL 89
Cdd:cd11491    3 AVVALYFILVMCIGIYamWKSNRSTVSGYFLAGRSMTWLPVGASLFASNIGSEHFIGLAGSGAAAGFAVGAFEFNALILL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  90 PLVFYFYIPFFRKLKVTSAYEYLEARFD-VRCRL-FASMSFMLFHIGRIAIITFLTVLALRPFIAIDPVILVLLISVMCI 167
Cdd:cd11491   83 QLLGWVFIPVYIRSGVYTLPEYLSKRFGgHRIQVyLAALSLILYIFTKISVNLYSGALFIQEALGWNLYVSIILLLGLTA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 168 IYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVICLKVQG----------GIGEIFTVTQQADKFFPATQFHWSWTESTV- 236
Cdd:cd11491  163 LLTVTGGLAAVIYTDTLQAFLMIIGALTLMIISMMEIGGfegvksrymlASPNVTSILLTYNLSNTNSCCVHPKKDAFKl 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 237 -----------PVLMIGFLFANIQQFTASQDVVQRYIVTDSIEETKKTLLTnAKLVAVIPVFFFA----IGSALF---VY 298
Cdd:cd11491  243 lrdptdedvpwPGFILGQTPASIWYWCADQVIVQRVLAAKSLSHAQGATLM-AGFIKLLPLFIIVipgmISRILFpddIA 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 299 YQQHPQLLPAGFNTGGI----LPLFVVTEMPVGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLSHKKRTPEnRM 374
Cdd:cd11491  322 CINPEHCMQVCGSRAGCsniaYPRLVMKIMPSGLRGLMMAVMIAALMSDLTSIFNSASTLFTLDVYKLIRKKASSRE-LM 400
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446550739 375 KIAKLVILVAGLISSAASVWLVMADESEIWDAFNSLIGLMGGPMTGLFMLGIFFKRANAGSAVLGIIISVIT 446
Cdd:cd11491  401 IVGRIFVAVMVVISIAWIPVIQEMQGGQLYLYIQEVAAYLTPPVASLYLLAIFWKRTTEQGAFYGGMAGFVL 472
SLC5sbd_DUR3 cd11476
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ...
12-481 8.95e-08

Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271370  Cd Length: 493  Bit Score: 54.51  E-value: 8.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  12 LVLFGYL-LAMMLVGVYFSRRQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIIGQYLAIAILP 90
Cdd:cd11476    8 GALFALLmVFITRLLKRYRGKNQSSEEFMTAGRSVGTGLTAAAIVSSWTWAATLLQSATVAYQYGVSGPFWYASGATLQI 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  91 LVFYFYIPFFRKL--KVTSAYEYLEARFDVRCRLFAsMSFMLFH---------IGRIAIITFLTvlalrpfiAIDPVILV 159
Cdd:cd11476   88 LLFAPLAIRIKRLapNAHTLLEIVRARYGTAAHLVF-LVFALFTnvivlamllLGGSAVVNALT--------GMPIVAAS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 160 LLISVMCIIYTWMGGIEGVIWTDVIQGL-LLSGSAILIFIVICLKVQGGIGEIFTVTQQADKFFPATQFHWSW-TESTVP 237
Cdd:cd11476  159 FLIPLGVLLYTLFGGLRATFLTDYIHTViILIILLVFAFAVYTSSDIGSPSKVYDLLQEAAPDLPVEGNQGSYlTFKSKA 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 238 VLMIG--FLFANIQQFTASQDVVQRYIVTDSIEETKKTLLTNAKLVAVIPVFFFAIGSAlFVYYQQHPQllPAGFNTGGI 315
Cdd:cd11476  239 GLIFGiiNIVGNFGTVFLDQGYWQRAIAARPSAAVKGYFLGGLAWFAIPFLLATTLGLA-ALALGLNPT--FEEVSAGLV 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 316 LPLFVVTEMPVGIAGLIIAAIFAAAQSSISSSLNSISSCFNSDIYQRLSHKKRTPENRMKIAKLVILVAGLISSAASVWL 395
Cdd:cd11476  316 LPYVAAALLGKGGAAAVLVLLFMAVTSTASAELIAVSSIVTYDIYRTYINPNATGKQLLRVSRIAVIGFGLFMGGLAVGL 395
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 396 VMADESEIWDAFnsLIGLMGGPMTGLFMLGIFFKRANA----GSAVLGIIISVITVLGARYA-------TDLNFFFYGVI 464
Cdd:cd11476  396 NYIGISLGWLLL--FMGILIGSAVFPVALGLYWRRQTGtaavVSPIAGLVAGLAVWLVTAKSyygevnvDTTGGNYPMLA 473
                        490
                 ....*....|....*..
gi 446550739 465 GSLSVVISGVIFAPLFA 481
Cdd:cd11476  474 GNLVALFSPAIVSVLLS 490
SLC5sbd_u4 cd11480
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
12-224 1.48e-07

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271374  Cd Length: 488  Bit Score: 53.66  E-value: 1.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  12 LVLFGYLLAMMLVGVYFSRRQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSD---WTFIIGqylAIAI 88
Cdd:cd11480    2 GLFFVFVTITLYITIWAARRTRSTSDFYVAGRGVPPVQNGLAIAGDYMSAASFLGIAGLIALSGydgLAYAIG---WTGG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  89 LPLVFYFYIPFFRKL-KVTSAyEYLEARFDVR-CRLFASmsfmlfhIGRIAIITFLTV-------LALRPFIAIDPVILV 159
Cdd:cd11480   79 YVLLLLLVAEPLRNFgKYTVP-DFLGARLGSRpVRLVAA-------VSTLVISFFYLVaqmvgagLLLSLLLGIPYEVGV 150
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739 160 LLISVMCIIYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVICLK-----VQGGIGEIFTVTQQADKFFPA 224
Cdd:cd11480  151 VVVGALMIVYVVLGGMRATTWVQIIQYVLLLGAFLVPAILVLARfggnpLGAGPGLLGLAAAAASGAGEA 220
ActP COG4147
Na+(or H+)/acetate symporter ActP [Energy production and conversion];
7-199 4.55e-07

Na+(or H+)/acetate symporter ActP [Energy production and conversion];


Pssm-ID: 443318  Cd Length: 526  Bit Score: 52.47  E-value: 4.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739   7 GIVNYLVLFGYLLAMMLVGVYFSRRQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDW---TFIIGqy 83
Cdd:COG4147   11 NLLAIGIFLVFVTFTLYITIWAARRTKSTSDFYVAGRGVTGVQNGLAIAGDYMSAASFLGIAGLIALSGYdglIYSIG-- 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  84 lAIAILPLVFYFYIPFFRKL-KVTSAyEYLEARFD-VRCRLFASmsfmlfhIGRIAIITFLTV-------LALRPFIAID 154
Cdd:COG4147   89 -WLVGYVLLLLLLAEYLRNFgKFTVP-DFLGDRFYsRPARLVAA-------ISTLVVSFFYLIaqmvgagVLISLLLGVD 159
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 446550739 155 PVILVLLISVMCIIYTWMGGIEGVIWTDVIQ-GLLLSGSAILIFIV 199
Cdd:COG4147  160 YEVAVVIVGVLMIVYVVLGGMKGTTWVQIIKaVLLIFAYTVPAVLV 205
panF TIGR02119
sodium/pantothenate symporter; Pantothenate (vitamin B5) is a precursor of coenzyme A and is ...
12-219 8.51e-07

sodium/pantothenate symporter; Pantothenate (vitamin B5) is a precursor of coenzyme A and is made from aspartate and 2-oxoisovalerate in most bacteria with completed genome sequences. However, some pathogens must import pantothenate. This model describes PanF, a sodium/pantothenate symporter, from a larger family of Sodium/substrate symporters (pfam00474). Several species that have this transporter appear to lack all enzymes of pantothenate biosynthesis, namely Haemophilus influenzae, Pasteurella multocida, Fusobacterium nucleatum, and Borrelia burgdorferi. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A, Transport and binding proteins, Other]


Pssm-ID: 131174  Cd Length: 471  Bit Score: 51.27  E-value: 8.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739   12 LVLFGYLLAMMLVGVYFSRRQKTAD----DYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIIgqyLAIA 87
Cdd:TIGR02119   5 IPLIIYLVTVFLIAIYASKRVQSTDsflnEYFLGGRSMGGFVLAMTLVATYGSASSFIGGPGIAYNYGLGWVL---LAMI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739   88 ILPLVFY--------FYIpFFRKLKVTSAYEYLEARFDVR-CRLFASMSFMLFHIGRIAIITFLTVLALRPFIAIDPVIL 158
Cdd:TIGR02119  82 QVPTGYFvlgvlgkkFAI-ISRKYNAITINDVLKARYNNKfLVWLSSISLLVFFFSAMVAQFIGGARLIESLTGLSYLTA 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446550739  159 VLLISVMCIIYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVIcLKVQGGIGEIFTVTQQAD 219
Cdd:TIGR02119 161 LFIFSSSVLIYTTFGGFRAVALTDAIQGIVMFTGTTILLIAV-IKAGGGVEKIMEKLKDID 220
PRK15419 PRK15419
sodium/proline symporter PutP;
17-217 6.35e-06

sodium/proline symporter PutP;


Pssm-ID: 185317  Cd Length: 502  Bit Score: 48.47  E-value: 6.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  17 YLLAMMLVGVYFSRRQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDwtfIIGQYLAIAILPLVFYFY 96
Cdd:PRK15419  14 YIFGMILIGFIAWRSTKNFDDYILGGRSLGPFVTALSAGASDMSGWLLMGLPGAVFLSG---ISESWIAIGLTLGAWINW 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  97 IPFFRKLKVTSAY--------EYLEARFDVRCRLfasmsfmLFHIGRIAIITFLTVLALRPFIA----------IDPVIL 158
Cdd:PRK15419  91 KLVAGRLRVHTEYnnnaltlpDYFTGRFEDKSRI-------LRIISALVILLFFTIYCASGIVAgarlfestfgMSYETA 163
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446550739 159 VLLISVMCIIYTWMGGIEGVIWTDVIQGLLLSGSAILIFIVICLKVqGGIGEIFTVTQQ 217
Cdd:PRK15419 164 LWAGAAATILYTFIGGFLAVSWTDTVQASLMIFALILTPVIVIISV-GGFGDSLEVIKQ 221
PRK12488 PRK12488
cation/acetate symporter;
8-200 6.04e-05

cation/acetate symporter;


Pssm-ID: 237114 [Multi-domain]  Cd Length: 549  Bit Score: 45.56  E-value: 6.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739   8 IVNYLVLFGYLLAmmlVGVYFSRRQKTADDYFRGGGRVPGWAAGVSVFATTLSSITFMSIPAKAFTSDWTFIIGQYLAIA 87
Cdd:PRK12488  35 IGMFMVFVLFTLG---ITRWAARRTRSASDFYTAGGGLTGMQNGLAIAGDMISAASFLGISAMMFMNGYDGLLYALGVLA 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446550739  88 ILPLVFYFYIPFFRKLKVTSAYEYLEARFD-VRCRLFASmsfmlfhIGRIAIITFLTVLAL-------RPFIAIDPVILV 159
Cdd:PRK12488 112 GWPIILFLIAERLRNLGKYTFADVVSYRLAqGPVRLTAA-------FGTLTVVLMYLVAQMvgagkliELLFGISYLYAV 184
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 446550739 160 LLISVMCIIYTWMGGIEGVIWTDVIQG-LLLSGSAILIFIVI 200
Cdd:PRK12488 185 VIVGALMVLYVTFGGMLATTWVQIIKAvLLLSGTSFMAFMVL 226
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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