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Conserved domains on  [gi|446548536|ref|WP_000625882|]
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iron ABC transporter permease [Staphylococcus aureus]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 28-336 1.36e-94

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 283.11  E-value: 1.36e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536  28 SITSGEYNIPVERFFKTLIG-QGDAIDKLILLDFRLPRMMITILAGAALSISGAIVQSVTKNPIAEPGILGINAGGGFAI 106
Cdd:COG0609    1 SLSLGAVPISLSDVLRALLGpDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 107 ALFIAIGkinADNFVYVLPLISILGGITTALIIFIFSfNKNEGVTPASMVLIGVGLQTALYGGSITIMSKFDDKQSDFIA 186
Cdd:COG0609   81 VLAIVLG---GGLSALGLPLAAFLGALLAALLVYLLA-RRGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 187 AWFAGNIWGDEWPFVIAFLPWVLIIIPYLLFKSNTLNIIHTGDNIARGLGVRLSRERLILFFIAVMLSSAAVAVAGSISF 266
Cdd:COG0609  157 FWLMGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGF 236

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 267 IGLMGPHIAKRIVGPRHQLFLPIAILVGACLLVIADTIGKIVLQPGGVPAGIVVAIIGAPYFLYLMYKTK 336
Cdd:COG0609  237 VGLVVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 28-336 1.36e-94

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 283.11  E-value: 1.36e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536  28 SITSGEYNIPVERFFKTLIG-QGDAIDKLILLDFRLPRMMITILAGAALSISGAIVQSVTKNPIAEPGILGINAGGGFAI 106
Cdd:COG0609    1 SLSLGAVPISLSDVLRALLGpDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 107 ALFIAIGkinADNFVYVLPLISILGGITTALIIFIFSfNKNEGVTPASMVLIGVGLQTALYGGSITIMSKFDDKQSDFIA 186
Cdd:COG0609   81 VLAIVLG---GGLSALGLPLAAFLGALLAALLVYLLA-RRGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 187 AWFAGNIWGDEWPFVIAFLPWVLIIIPYLLFKSNTLNIIHTGDNIARGLGVRLSRERLILFFIAVMLSSAAVAVAGSISF 266
Cdd:COG0609  157 FWLMGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGF 236

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 267 IGLMGPHIAKRIVGPRHQLFLPIAILVGACLLVIADTIGKIVLQPGGVPAGIVVAIIGAPYFLYLMYKTK 336
Cdd:COG0609  237 VGLVVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 20-334 3.38e-77

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 238.97  E-value: 3.38e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536   20 LLFLGCTWSITSGEYNIPVERFFKTLIGQGDAIDKLILLDFRLPRMMITILAGAALSISGAIVQSVTKNPIAEPGILGIN 99
Cdd:pfam01032   1 LLLLLILLSLFIGAVKISPSDVFSALLGGDDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536  100 AGGGFAIALFIAIGkinADNFVYVLPLISILGGITTALIIFIFSfNKNEGVTPASMVLIGVGLQTALYGGSITIMSKFDD 179
Cdd:pfam01032  81 SGAALGAVLAILLG---GSLSLFALPLAAFIGALLAALLVYFLS-RGRGGASPLRLILAGIAVSALLSALTSLLLLLLNP 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536  180 KQSDFIAAWFAGNIWGDEWPFVIAFLPWVLIIIPYLLFKSNTLNIIHTGDNIARGLGVRLSRERLILFFIAVMLSSAAVA 259
Cdd:pfam01032 157 EALQSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVA 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446548536  260 VAGSISFIGLMGPHIAKRIVGPRHQLFLPIAILVGACLLVIADTIGKIVLQPGGVPAGIVVAIIGAPYFLYLMYK 334
Cdd:pfam01032 237 VVGPIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
7-335 4.67e-69

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 227.80  E-value: 4.67e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536   7 KRRQLIALAVFSILLFLGCTWSITSGeyniPVERFFKTLIGQGDAIdkliLLDFRLPRMMITILAGAALSISGAIVQSVT 86
Cdd:PRK10577 351 RRRVLAWLLALGLLLLLALVVALSFG----RDAHGWNWLSGQLLDA----LLPLRLPRLLAALLAGAMLAVAGTLLQRLT 422

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536  87 KNPIAEPGILGINAGGGFAIALFIAIGkinADNFVYVLPLISILGGITTALIIFIFsfNKNEGVTPASMVLIGVGLQTAL 166
Cdd:PRK10577 423 RNPLASPEVLGISSGAGLGVVLALFLV---PGAGFGWLLAAALLGALAALALILLL--ARRGGFAPERLLLTGIALSALF 497

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 167 YGGSITIMSKFDDKQSDFIAaWFAGNIWGDEWPFVIAFLPWVLIIIPYLLFKSNTLNIIHTGDNIARGLGVRLSRERLIL 246
Cdd:PRK10577 498 TALIQLLLASGDPRAAQLLT-WLSGSTYGVTWAQALPLLIVAVLLLALALLLRRWLDLLPLGDDTARALGLPVTRARLAL 576

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 247 FFIAVMLSSAAVAVAGSISFIGLMGPHIAKRIVGPRHQLFLPIAILVGACLLVIADTIGKIVLQPGGVPAGIVVAIIGAP 326
Cdd:PRK10577 577 LLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLADWLGRTLLFPYQIPAGLLAALIGAP 656


                 ....*....
gi 446548536 327 YFLYLMYKT 335
Cdd:PRK10577 657 YFLWLLRRS 665
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 65-332 9.18e-47

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 158.87  E-value: 9.18e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536  65 MMITILAGAALSISGAIVQSVTKNPIAEPGILGINAGGGFAIALFIAIGKinaDNFVYVLPLISILGGITTALIIFIFSF 144
Cdd:cd06550    1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGI---GLSNYALGAFAFAGALAIALLVLLLAS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 145 NKneGVTPASMVLIGVGLqTALYGGSITIMSKFDDKQSDFIAAWFAGNIWGDEWPFVIAFLPWVLIIIPYLLFKSNTLNI 224
Cdd:cd06550   78 RG--GLSPSKLILIGIVL-SAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 225 IHTGDNIARGLGVRLSRERLILFFIAVMLSSAAVAVAGSISFIGLMGPHIAKRIVGPRHQLFLPIAILVGACLLVIADTI 304
Cdd:cd06550  155 LTFDEDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLL 234

                        250       260
                 ....*....|....*....|....*...
gi 446548536 305 GKIVLqPGGVPAGIVVAIIGAPYFLYLM 332
Cdd:cd06550  235 SRTLL-PSELPVGPVTALLGAPYFLYLL 261
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 28-336 1.36e-94

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 283.11  E-value: 1.36e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536  28 SITSGEYNIPVERFFKTLIG-QGDAIDKLILLDFRLPRMMITILAGAALSISGAIVQSVTKNPIAEPGILGINAGGGFAI 106
Cdd:COG0609    1 SLSLGAVPISLSDVLRALLGpDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 107 ALFIAIGkinADNFVYVLPLISILGGITTALIIFIFSfNKNEGVTPASMVLIGVGLQTALYGGSITIMSKFDDKQSDFIA 186
Cdd:COG0609   81 VLAIVLG---GGLSALGLPLAAFLGALLAALLVYLLA-RRGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 187 AWFAGNIWGDEWPFVIAFLPWVLIIIPYLLFKSNTLNIIHTGDNIARGLGVRLSRERLILFFIAVMLSSAAVAVAGSISF 266
Cdd:COG0609  157 FWLMGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGF 236

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 267 IGLMGPHIAKRIVGPRHQLFLPIAILVGACLLVIADTIGKIVLQPGGVPAGIVVAIIGAPYFLYLMYKTK 336
Cdd:COG0609  237 VGLVVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 20-334 3.38e-77

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 238.97  E-value: 3.38e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536   20 LLFLGCTWSITSGEYNIPVERFFKTLIGQGDAIDKLILLDFRLPRMMITILAGAALSISGAIVQSVTKNPIAEPGILGIN 99
Cdd:pfam01032   1 LLLLLILLSLFIGAVKISPSDVFSALLGGDDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536  100 AGGGFAIALFIAIGkinADNFVYVLPLISILGGITTALIIFIFSfNKNEGVTPASMVLIGVGLQTALYGGSITIMSKFDD 179
Cdd:pfam01032  81 SGAALGAVLAILLG---GSLSLFALPLAAFIGALLAALLVYFLS-RGRGGASPLRLILAGIAVSALLSALTSLLLLLLNP 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536  180 KQSDFIAAWFAGNIWGDEWPFVIAFLPWVLIIIPYLLFKSNTLNIIHTGDNIARGLGVRLSRERLILFFIAVMLSSAAVA 259
Cdd:pfam01032 157 EALQSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVA 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446548536  260 VAGSISFIGLMGPHIAKRIVGPRHQLFLPIAILVGACLLVIADTIGKIVLQPGGVPAGIVVAIIGAPYFLYLMYK 334
Cdd:pfam01032 237 VVGPIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
7-335 4.67e-69

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 227.80  E-value: 4.67e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536   7 KRRQLIALAVFSILLFLGCTWSITSGeyniPVERFFKTLIGQGDAIdkliLLDFRLPRMMITILAGAALSISGAIVQSVT 86
Cdd:PRK10577 351 RRRVLAWLLALGLLLLLALVVALSFG----RDAHGWNWLSGQLLDA----LLPLRLPRLLAALLAGAMLAVAGTLLQRLT 422

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536  87 KNPIAEPGILGINAGGGFAIALFIAIGkinADNFVYVLPLISILGGITTALIIFIFsfNKNEGVTPASMVLIGVGLQTAL 166
Cdd:PRK10577 423 RNPLASPEVLGISSGAGLGVVLALFLV---PGAGFGWLLAAALLGALAALALILLL--ARRGGFAPERLLLTGIALSALF 497

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 167 YGGSITIMSKFDDKQSDFIAaWFAGNIWGDEWPFVIAFLPWVLIIIPYLLFKSNTLNIIHTGDNIARGLGVRLSRERLIL 246
Cdd:PRK10577 498 TALIQLLLASGDPRAAQLLT-WLSGSTYGVTWAQALPLLIVAVLLLALALLLRRWLDLLPLGDDTARALGLPVTRARLAL 576

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 247 FFIAVMLSSAAVAVAGSISFIGLMGPHIAKRIVGPRHQLFLPIAILVGACLLVIADTIGKIVLQPGGVPAGIVVAIIGAP 326
Cdd:PRK10577 577 LLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLADWLGRTLLFPYQIPAGLLAALIGAP 656


                 ....*....
gi 446548536 327 YFLYLMYKT 335
Cdd:PRK10577 657 YFLWLLRRS 665
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
56-336 2.15e-58

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 191.03  E-value: 2.15e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536  56 ILLDFRLPRMMITILAGAALSISGAIVQSVTKNPIAEPGILGINAGGGFAiALFIAIGKINADnfVYVLPLISILGGITT 135
Cdd:PRK09777  46 VLMEYRLPRLLLALFVGAALAVSGVLVQGIVRNPLASPDILGVNHAASLA-SVGALLLFPSLP--VMWLPLLAFIGGMAG 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 136 ALII-FIFSFNknegvTPASMVLIGVGLqTALYGgSIT---IMSKFDDKQSDFIaaWFAGNIWGDEWPFVIAFLPWVLII 211
Cdd:PRK09777 123 LILLkMLAGTH-----QPMKLALTGVAL-SALWA-SLTdylMLSRPQDINNALL--WLTGSLWGRDWSFVKVALPWLILL 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 212 IPYLLFKSNTLNIIHTGDNIARGLGVRLSRERLILFFIAVMLSSAAVAVAGSISFIGLMGPHIAKRIVGPRHQLFLPIAI 291
Cdd:PRK09777 194 LPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALLLAVALTATGVAACGPISFIGLVVPHLMRSLVGGRHRRLLPVSA 273

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 446548536 292 LVGACLLVIADTIGKIVLQPGGVPAGIVVAIIGAPYFLYLMYKTK 336
Cdd:PRK09777 274 LTGALLLLLADLLARIIHPPLELPAGVLTAIIGAPWFFWLLVRMR 318
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
13-337 3.05e-54

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 188.12  E-value: 3.05e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536  13 ALAVFSILLFLGCTWSITSGEYNIPVERFFKTLIGQG-DAIDKLILLDFRLPRMMITILAGAALSISGAIVQSVTKNPIA 91
Cdd:PRK10577  13 PALLLALLLLLALALTLTQLSAALPLSQWLQALWGPDaDDLEQLLLHYSRLPRLAIALLVGAALGLAGALLQQVLRNPLA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536  92 EPGILGINAGGGFAIALFIAIGkinADNFVYVLPLISILGGITTALIIFIFSFNKneGVTPASMVLigVGLQTALYGGSI 171
Cdd:PRK10577  93 SPTTLGVAAGAQLALVLATLFA---PALLALASQLAAFAGGLLAAALVFALAGGK--RLSPLRLVL--AGMVVSLYLGAL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 172 -TIMSKFDDKQSDFIAAWFAGNIWGDEWPFVIAFLPWVLIIIPYLLFKSNTLNIIHTGDNIARGLGVRLSRERLILFFIA 250
Cdd:PRK10577 166 tTLLLLFNEQYLQGLFLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALA 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 251 VMLSSAAVAVAGSISFIGLMGPHIAKRIVGPRHQLFLPIAILVGACLLVIADTIGKIVLQPGG--VPAGIVVAIIGAPYF 328
Cdd:PRK10577 246 VLLSAAVVSAVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLAGVGGelLPTGAVTALIGAPLL 325


                 ....*....
gi 446548536 329 LYLMYKTKN 337
Cdd:PRK10577 326 LWLLPRLRS 334
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
47-331 1.79e-50

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 170.65  E-value: 1.79e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536  47 GQGDAIDKLILLDFRLPRMMITILAGAALSISGAIVQSVTKNPIAEPGILGINAGGGFAIALFIAIGKINADNfvYVLPL 126
Cdd:PRK11228  37 GHTPTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALTSALSPTPFAG--YSLAF 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 127 ISILGGITTALIIFIFSFNKNEGVTPASMVLIGVGLqTALYGGSITIMSKFDDKQSDFIAAWFAGNIWGDEWPFVIAFLP 206
Cdd:PRK11228 115 IAACGGGLSWLLVMTAGGGWRHTHDRNRLILAGIAL-SALCMALTRITLLLAEDHAYGIFYWLAGGVSHARWQEVWQLLP 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 207 WVLIIIPYLLFKSNTLNIIHTGDNIARGLGVRLSRERLILFFIAVMLSSAAVAVAGSISFIGLMGPHIAKRIVGPRHQLF 286
Cdd:PRK11228 194 FVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVPHLARFWIGYDQRNV 273

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 446548536 287 LPIAILVGACLLVIADTIGKIVLQPGGVPAGIVVAIIGAPYFLYL 331
Cdd:PRK11228 274 LPMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWL 318
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
1-331 2.34e-48

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 165.27  E-value: 2.34e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536   1 MISSNNKRRQLIALAVFsILLFLGCTWSITSGEYNIPVERFFKTLIGQGDAIDKLILLDFRLPRMMITILAGAALSISGA 80
Cdd:PRK10441   1 MSGSVAVTRAIAVPGLL-LLLIIATALSLLIGAKSLPASVVLEALSGTCQSADCTIVLDARLPRTLAGLLAGGALGLAGA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536  81 IVQSVTKNPIAEPGILGINAGGGFAIALFIAIGKINADNFVYVLPLIsilGGITTALIIFIFSFNKNEGVTPASMVLIGV 160
Cdd:PRK10441  80 LMQTLTRNPLADPGLLGVNAGASFAIVLGAALFGYSSAQEQLAMAFA---GALVASLIVAFTGSQGGGQLSPVRLTLAGV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 161 GLQTALYGGSITImSKFDDKQSDFIAAWFAGNIWGDEWPFVIAFLPWVLIIIPYLLFKSNTLNIIHTGDNIARGLGVRLS 240
Cdd:PRK10441 157 ALAAVLEGLTSGI-ALLNPDVYDQLRFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVA 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 241 RERLILFFIAVMLSSAAVAVAGSISFIGLMGPHIAKRIVGPRHQLFLPIAILVGACLLVIADTIGKiVLQPGGVPAGIVV 320
Cdd:PRK10441 236 RTQLIGLLAITVLCGSATAVVGPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGR-LLVPGELRVSVVS 314

                        330
                 ....*....|.
gi 446548536 321 AIIGAPYFLYL 331
Cdd:PRK10441 315 AFIGAPVLIFL 325
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 65-332 9.18e-47

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 158.87  E-value: 9.18e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536  65 MMITILAGAALSISGAIVQSVTKNPIAEPGILGINAGGGFAIALFIAIGKinaDNFVYVLPLISILGGITTALIIFIFSF 144
Cdd:cd06550    1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGI---GLSNYALGAFAFAGALAIALLVLLLAS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 145 NKneGVTPASMVLIGVGLqTALYGGSITIMSKFDDKQSDFIAAWFAGNIWGDEWPFVIAFLPWVLIIIPYLLFKSNTLNI 224
Cdd:cd06550   78 RG--GLSPSKLILIGIVL-SAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 225 IHTGDNIARGLGVRLSRERLILFFIAVMLSSAAVAVAGSISFIGLMGPHIAKRIVGPRHQLFLPIAILVGACLLVIADTI 304
Cdd:cd06550  155 LTFDEDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLL 234

                        250       260
                 ....*....|....*....|....*...
gi 446548536 305 GKIVLqPGGVPAGIVVAIIGAPYFLYLM 332
Cdd:cd06550  235 SRTLL-PSELPVGPVTALLGAPYFLYLL 261
btuC PRK09535
cobalamin ABC transporter permease BtuC;
50-332 3.06e-44

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 155.29  E-value: 3.06e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536  50 DAIDKLILLDFRLPRMMITILAGAALSISGAIVQSVTKNPIAEPGILGINAGGGFAIALFIAIGKInadnFVYVLPLISI 129
Cdd:PRK09535  84 PETAQTIVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGAVAAIVLPLA----VPFGLQAAAF 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 130 LGGITTALIIFIFSfnKNEGVTP-ASMVLIGVGLQTALyGGSITIMSKFDDKQSDFIAAWFAGNIWGDEWPFVIAFLPWV 208
Cdd:PRK09535 160 AGALVAAFGVYAIA--TENGRTPvATLLLAGVAVQTFL-GAVISYLLLHSGESLRRAVYWLMGHLHGSTWSDVEVALPVV 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 209 LIIIPYLLFKSNTLNIIHTGDNIARGLGVRLSRERLILFFIAVMLSSAAVAVAGSISFIGLMGPHIAKRIVGPRHQLFLP 288
Cdd:PRK09535 237 VVGFVVLLAYARDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRILLP 316

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 446548536 289 IAILVGACLLVIADTIGKivLQPGGVPAGIVVAIIGAPYFLYLM 332
Cdd:PRK09535 317 TSALAGASFLVATDTVAR--SGPAEVPVGIVTAALGAPFFLYLL 358
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 7-336 4.22e-44

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 153.96  E-value: 4.22e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536   7 KRRQLIALAVFSILLFLGCTWSITSGEYNIPVERFFktligqgDAIDKLILLDFRLPRMMITILAGAALSISGAIVQSVT 86
Cdd:PRK03784  11 QRRNRRWLLGLSVLLLLALLLSLCAGEQWISPGDWL-------SPRGELFVWQLRLPRTLAVLLVGAALAVSGAVMQALF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536  87 KNPIAEPGILGINAGGGFAIALFIAIGKINADnfVYVLPLISILGGITTALIIFIFSfnKNEGVTPASMVLIGVGLQTaL 166
Cdd:PRK03784  84 ENPLAEPGLLGVSNGAGVALVAAVLLGQGLLP--PWALSLCAIAGALLITLILLRFA--RRHRLSTSRLLLAGVALGI-I 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 167 YGGSITIMSKFDDKQS-DFIAAWFAGNIWGDEWPFVIAFLPWVLIIIpYLLFKSNTLNIIHTGDNIARGLGVRLSRERLI 245
Cdd:PRK03784 159 CSALMTWAVYFSTSLDlRQLMYWMMGGFGGVDWRQSWLMLALLPVLI-WLCCQGRPLNMLALGEISARQLGLPLWFWRNL 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 246 LFFIAVMLSSAAVAVAGSISFIGLMGPHIAKRIVGPRHQLFLPIAILVGACLLVIADTIGKIVLQPGGVPAGIVVAIIGA 325
Cdd:PRK03784 238 LVLATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGASLLLLADIVARLALASAELPIGVVTATLGA 317

                        330
                 ....*....|.
gi 446548536 326 PYFLYLMYKTK 336
Cdd:PRK03784 318 PVFIWLLLRSH 328
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 7-338 2.48e-43

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 151.93  E-value: 2.48e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536   7 KRRQLIALAVFSILLFLGCTWSITSGEYNIPVERFFKTLigqgdaiDKLILLDFRLPRMMITILAGAALSISGAIVQSVT 86
Cdd:COG4139    8 RRRDRRWLLLLLLLLLLLFVLSLCAGEVWIPPTQWLSEA-------WQLFVWQLRLPRTLAAVLVGASLAVSGAVMQALF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536  87 KNPIAEPGILGINAGGGFAIALFIAIGKINADnfVYVLPLISILGGITTALIIFIFSfnkNEGVTPASMVLIGVGLQTaL 166
Cdd:COG4139   81 ENPLAEPGLLGISNGAGVGLVLVVLLGGGLLP--PWLLSLAAIAGALLVTLLLLAFA---RRRLSNARLLLIGVALGI-I 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 167 YGGSITIMSKF-DDKQSDFIAAWFAGNIWGDEWPFVIAFLPwVLIIIPYLLFKSNTLNIIHTGDNIARGLGVRLSRERLI 245
Cdd:COG4139  155 CSAIMTWAVYFsSSLDLRQLMYWMMGSFGGVDWRQLWLLLA-LLPVLLWLCLQGKPLNLLLLGENQARQLGLSVHRWRNL 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 246 LFFIAVMLSSAAVAVAGSISFIGLMGPHIAKRIVGPRHQLFLPIAILVGACLLVIADTIGKIVLQPGGVPAGIVVAIIGA 325
Cdd:COG4139  234 LVLATGLLVGVSVALAGPIGFVGLVVPHLLRLLGTTDHRFLLPACALAGAALLLLADIIARLALSSAELPIGVVTATLGA 313

                        330
                 ....*....|...
gi 446548536 326 PYFLYLMYKTKNV 338
Cdd:COG4139  314 PVFIWLLLRRRKI 326
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
14-332 2.05e-39

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 141.77  E-value: 2.05e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536  14 LAVFSILLFLGCT----WSITSGEYNIPVERFFKTLIGQGDAIDKLILLDFRLPRMMITILAGAALSISGAIVQSVTKNP 89
Cdd:PRK10440   8 LLITCLLLLAACVaaglWGLRSGAVTLETSQVFAALMGDAPRSMTMVVTEWRLPRVLMALLIGAALGVSGAIFQSLMRNP 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536  90 IAEPGILGINAGGGFAIALFIAIGKINadnfVYVLPLISILGGITTALIIFIFSFNKneGVTPASMVLIGVGLQTALYGG 169
Cdd:PRK10440  88 LGSPDVMGFNTGAWSGVLVAMVLFGQD----LTAIALAAMAGGIVTSLLVWLLAWRN--GIDTFRLIIIGIGVRAMLVAF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 170 SITIMSKFDDKQSDFIAAWFAGNIWGDEWPFVIAFLPWVLIIIPYLLFKSNTLNIIHTGDNIARGLGVRLSRERLILFFI 249
Cdd:PRK10440 162 NTWLLLKASLETALTAGLWNAGSLNGLTWAKTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERSRLLLMLV 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446548536 250 AVMLSSAAVAVAGSISFIGLMGPHIAKRIVGPRhQLFLPIAILVGACLLVIADTIGKIVLQPGGVPAGIVVAIIGAPYFL 329
Cdd:PRK10440 242 AVVLTAAATALAGPISFIALVAPHIARRLSGTA-RWGLTQAALCGALLLLAADLCAQQLFMPYQLPVGVVTVSLGGIYLI 320


                 ...
gi 446548536 330 YLM 332
Cdd:PRK10440 321 VLL 323
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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