|
Name |
Accession |
Description |
Interval |
E-value |
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
1-1049 |
0e+00 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 1179.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 1 MIRNLLEGMMRFRVATLAASVGAIVFGIWAWIDIRKEAYSDIADTQVRLIAKFPGKAAVEVEERVTIPIERVLNAIPKVA 80
Cdd:COG3696 1 MLNRIIRFSLRNRLLVLLLTLLLAAAGIYSLRRLPIDAFPDITNVQVQVITEAPGLSPEEVEQQVTYPIETALNGLPGVK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 81 VRRSRTINGLVVFQFVFEDGTDDYFARTRLLERVRDA--DIPSEVEPTLGPMSSPVGEIYRYVVESKAN-HTPMELRTIQ 157
Cdd:COG3696 81 EVRSISRFGLSVVTVIFEDGTDIYWARQLVLERLQQVreQLPAGVTPELGPISTGLGEIYQYTLESDPGkYSLMELRTLQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 158 DWNIMPKMLSIPGIADVVTFGGLPKQFHVVTTPDRLIRYKLTIEDVINAIQKNNLNTGGNLLLQGEQGFPIRSLGAIRTP 237
Cdd:COG3696 161 DWVIRPQLRSVPGVAEVNSFGGFVKQYQVLVDPAKLRAYGLTLDDVIEALERNNANVGGGYIERGGQEYLVRGIGLIRSL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 238 EHIENIVVKTENGVPVFIRDLGSVEISHPIPSGVLGYtiqNDQeglidvDSSVQGLVAIRRWGDPNIMGERIRAKVKEIN 317
Cdd:COG3696 241 EDIENIVVKTRNGTPVLLRDVAEVRIGPAPRRGAATL---NGE------GEVVGGIVLMLKGENALEVIEAVKAKLAELK 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 318 dNYLPDGVQIRNTYDRTDLVNYTLRTIGKTLVEGVVVVSLVLIFFIGSIKASMVVVATIPFAMLFAFLLMNITGIPASLL 397
Cdd:COG3696 312 -PSLPEGVKIVPFYDRSDLIDRAIHTVTKNLLEGALLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLFGISANLM 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 398 SLG--AIDFGIIVDGAVVMVENVMRRYRDASPTDKKKGIVRFTVDAASEVGTEIIFSILIIILAYLPIFSFERIEGRLFK 475
Cdd:COG3696 391 SLGglAIDFGIIVDGAVVMVENILRRLEENRAAGTPRERLEVVLEAAREVRRPIFFATLIIILVFLPIFTLEGVEGKLFR 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 476 PMAFTISFAILGALIFSMTAIPVLMSYIYRNYFEsqnpgpiEWHNPFYDWVERKYERLIEYLVERSKRVVVICFSIVGTL 555
Cdd:COG3696 471 PMALTVIFALLGALLLSLTLVPVLASLLLRGKVP-------EKENPLVRWLKRLYRPLLRWALRHPKLVLAVALVLLVLA 543
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 556 LVAGgLSLGTEFLPEMDEGGFNLRIFFPVGISLPESRKFIPKIREMIYRNEQVNVVLSQLGRNDDGTDPLPPNRLEVLVS 635
Cdd:COG3696 544 LALF-PRLGSEFLPELDEGDLLVMATLPPGISLEESVELGQQVERILKSFPEVESVVSRTGRAEDATDPMGVNMSETFVI 622
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 636 LKDYNDWKEKITKQELLIRMRNDLEaGLPGARVSFSQPIMDNLSEAIMGTIADLAVFVSGNDLKIMRQIASEVLEIVKDM 715
Cdd:COG3696 623 LKPRSEWRSGRTKEELIAEMREALE-QIPGVNFNFSQPIQMRVDELLSGVRADVAVKIFGDDLDVLRRLAEQIEAVLKTV 701
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 716 KGASEFGIEQEADSPQLTVRIDREAAARYGINVNDVQQMVEAAIGMQRIDTLYEGPsdvppktpARFGIVVRFSKDYRSS 795
Cdd:COG3696 702 PGAADVQVERVTGLPQLDIRIDRDAAARYGLNVADVQDVVETAIGGKAVGQVYEGE--------RRFDIVVRLPEELRDD 773
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 796 KRAIENIPIISPKGERIPLSELAKISLEDGPTMIFRQEGRRTVTVRTNIRGRDQGGFVAELRQRVQKKIKLPEGYEIRYG 875
Cdd:COG3696 774 PEAIRNLPIPTPSGAQVPLSQVADIEVVEGPNQISRENGRRRIVVQANVRGRDLGSFVAEAQAKVAEQVKLPPGYYIEWG 853
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 876 GQYENLARVGTRLAIVIPLTVGIIFGVLYLLYKNLKYVYVALACIPLSLVGGIYALLLRGYYFNVSGGVGFISLFGIATM 955
Cdd:COG3696 854 GQFENLQRATARLAIVVPLALLLIFLLLYLAFGSVRDALLILLNVPFALIGGVLALWLRGMPLSVSAGVGFIALFGVAVL 933
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 956 AGVLFVSRTNHLLHEDdeISVREAVKKAAVIQLRPMLMTILLALLGLIPATLASGVGSDVQRPLATVIVGGLFSALFLVL 1035
Cdd:COG3696 934 NGVVLVSYINQLRAEG--LDLREAIIEGALERLRPVLMTALVAALGLLPMALSTGPGSEVQRPLATVVIGGLITSTLLTL 1011
|
1050
....*....|....
gi 446543436 1036 TVLPSLYLILVGER 1049
Cdd:COG3696 1012 LVLPALYLLFGRRR 1025
|
|
| 2A0601 |
TIGR00914 |
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ... |
1-1056 |
0e+00 |
|
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129992 [Multi-domain] Cd Length: 1051 Bit Score: 749.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 1 MIRNLLEGMMRFRVATLAASVGAIVFGIWAWIDIRKEAYSDIADTQVRLIAKFPGKAAVEVEERVTIPIERVLNAIPKVA 80
Cdd:TIGR00914 1 MIERIISFSVAQRWLVLLATLVMAILGIWSYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 81 VRRSRTINGLVVFQFVFEDGTDDYFARTRLLERVRDA--DIPSEVEPTLGPMSSPVGEIYRYVVESKAN--------HTP 150
Cdd:TIGR00914 81 TTRSLSRYGLSQVTVIFKDGTDLYFARQLVNERLQQArdNLPEGVSPEMGPISTGLGEIFLYTVEAEEGarkkdggaYTL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 151 MELRTIQDWNIMPKMLSIPGIADVVTFGGLPKQFHVVTTPDRLIRYKLTIEDVINAIQKNNLNTGGNLLLQGEQGFPIRS 230
Cdd:TIGR00914 161 TDLRTIQDWIIRPQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVRA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 231 LGAIRTPEHIENIVVKTENGVPVFIRDLGSVEISHPIPSGVlgyTIQNDQEglidvdsSVQGLVAIRRWGDPNIMGERIR 310
Cdd:TIGR00914 241 PGQVQSMDDIRNIVIATGEGVPIRIRDVARVQIGKELRTGA---ATENGKE-------VVLGTVFMLIGENSRTVAQAVG 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 311 AKVKEINDNyLPDGVQIRNTYDRTDLVNYTLRTIGKTLVEGVVVVSLVLIFFIGSIKASMVVVATIPFAMLFAFLLMNIT 390
Cdd:TIGR00914 311 DKLETINKT-LPEGVEIVTTYDRSQLVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPLSLLITFIGMVFQ 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 391 GIPASLLSLGAIDFGIIVDGAVVMVENVMRR-----YRDASPTDKKKgivRFTV--DAASEVGTEIIFSILIIILAYLPI 463
Cdd:TIGR00914 390 GISANLMSLGALDFGLIVDGAVVIVENAHRRlaeaqHHHGRQLTLKE---RLHEvfAASREVRRPLIFGQLIITLVFLPI 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 464 FSFERIEGRLFKPMAFTISFAILGALIFSMTAIPVLMSYIYRNYFEsqnpgpiEWHNPFYDWVERKYERLIEYLVERSKr 543
Cdd:TIGR00914 467 FTLTGVEGKMFHPMAFTVVLALAGAMILSLTFVPAAVALFIRGKVA-------EKENRLMRVLKRRYEPLLERVLAWPA- 538
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 544 vVVICFSIVGTLLVAGGLS-LGTEFLPEMDEGGFNLRIFFPVGISLPESRKFIPKIREMIYRNEQVNVVLSQLGRNDDGT 622
Cdd:TIGR00914 539 -VVLGAAAVSIVLVVWIASrVGGEFIPSLNEGDLAYQALRIPGTSLAQSVAMQQTLEKLIKSFPEVARVFAKTGTAEIAT 617
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 623 DPLPPNRLEVLVSLKDYNDWKE-KITKQELLIRMRnDLEAGLPGARVSFSQPIMDNLSEAIMGTIADLAVFVSGNDLKIM 701
Cdd:TIGR00914 618 DPMPPNASDTYIILKPESQWPEgKKTKEDLIEEIQ-EATVRIPGNNYEFTQPIQMRFNELISGVRSDVAVKVFGDDLDDL 696
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 702 RQIASEVLEIVKDMKGASEFGIEQEADSPQLTVRIDREAAARYGINVNDVQQMVEAAIGMQRIDTLYEGPsdvppktpAR 781
Cdd:TIGR00914 697 DATAEKISAVLKGVPGAADVKVEQTTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETFEGD--------RR 768
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 782 FGIVVRFSKDYRSSKRAIENIPIISPKGE-----RIPLSELAKISLEDGPTMIFRQEGRRTVTVRTNIRGRDQGGFVAEL 856
Cdd:TIGR00914 769 FDIVIRLPESLRESPQALRQLPIPLPLSEdarkqFIPLSDVADLRVSPGPNQISRENGKRRVVVSANVRGRDLGSFVDDA 848
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 857 RQRVQKKIKLPEGYEIRYGGQYENLARVGTRLAIVIPLTVGIIFGVLYLLYKNLKYVYVALACIPLSLVGGIYALLLRGY 936
Cdd:TIGR00914 849 KKAIAEQVKLPPGYWITWGGQFEQLQSATKRLQIVVPVTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALWLRGI 928
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 937 YFNVSGGVGFISLFGIATMAGVLFVSRTNHLLheDDEISVREAVKKAAVIQLRPMLMTILLALLGLIPATLASGVGSDVQ 1016
Cdd:TIGR00914 929 PLSISAAVGFIALSGVAVLNGLVMISFIRKLL--EEGPSLDEAVYEGALTRVRPVLMTALVASLGFVPMAIATGTGAEVQ 1006
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|
gi 446543436 1017 RPLATVIVGGLFSALFLVLTVLPSLYLILVGERDYVPKKQ 1056
Cdd:TIGR00914 1007 RPLATVVIGGIITATLLTLFVLPALYRLVHRRRHKGRKEH 1046
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
13-1045 |
0e+00 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 677.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 13 RVATLAASVGAIVFGIWAWIDIRKEAYSDIADTQVRLIAKFPGKAAVEVEERVTIPIERVLNAIPKVAVRRSRTINGLVV 92
Cdd:pfam00873 9 PIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSSQSSYGLSS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 93 FQFVFEDGTDDYFARTRLLERVRDA--DIPSEV-EPTLGPMSSPVGEIYRYVVESKAN-HTPMELRTIQDWNIMPKMLSI 168
Cdd:pfam00873 89 ITLTFELGTDIDIARQDVQNRLQLAtpLLPEGVqRPGISVIKTSLGPIMVLAVTSPDGsYTQTDLRDYADTNIKPQLSRV 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 169 PGIADVVTFGGLPKQFHVVTTPDRLIRYKLTIEDVINAIQKNNLNTGGNLLLQGEQGFPIRSLGAIRTPEHIENIVVKTE 248
Cdd:pfam00873 169 PGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAEDFEKIIVKNQ 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 249 NGVPVFIRDLGSVEIshpipsGVLGYTI---QNDQEGLidvdssvqgLVAIRRWGDPNIM--GERIRAKVKEINDnYLPD 323
Cdd:pfam00873 249 DGSPVRLRDVATVEL------GSELYRGfatFNGKPAV---------GLGVQKLPGANAIetADAVRAKLAELKP-TFPQ 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 324 GVQIRNTYDRTDLVNYTLRTIGKTLVEGVVVVSLVLIFFIGSIKASMVVVATIPFAMLFAFLLMNITGIPASLLSLGAID 403
Cdd:pfam00873 313 GVEIVVVYDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLV 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 404 F--GIIVDGAVVMVENVMRRYRdASPTDKKKGIVRftvdAASEVGTEIIFSILIIILAYLPIFSFERIEGRLFKPMAFTI 481
Cdd:pfam00873 393 LaiGLVVDDAIVVVENIERVLE-ENGLKPLEAAYK----SMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITI 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 482 SFAILGALIFSMTAIPVLMSYIYRNYFESQNPGPIEWHNPFYDWVERKYERLIEYLVERSKRVVVICFSIVGtLLVAGGL 561
Cdd:pfam00873 468 VLAILLSVLVALTLTPALCATLLKPRREPKHGGFFRWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVV-GSVWLFV 546
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 562 SLGTEFLPEMDEGGFNLRIFFPVGISLPESRKFIPKIREMIYRNEQVNVVLSQLGRNDDGtDPLPPNRLEVLVSLKDYND 641
Cdd:pfam00873 547 RIPTEFLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFAFSG-DNNGPNSGDAFISLKPWKE 625
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 642 WK-EKITKQELLIRMRNDLEAgLPGARVSFSQPIMDNLSEAIMGTIADLAVFVSGNDLKIMRQIASEVLEIVKDMKGASE 720
Cdd:pfam00873 626 RPgPEKSVQALIERLRKALKQ-IPGANVFLFQPIQLRGLGTISGFRSDLQVKIFGDDLDALDEARNQILAALAQLPGLSD 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 721 FGIEQEADSPQLTVRIDREAAARYGINVNDVQQMVEAAIGMQRIDTLYEGPSdvppktpaRFGIVVRFSKDYRSSKRAIE 800
Cdd:pfam00873 705 VRSDGQEDQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGR--------VYDVVVQLPEDFRSSPEDIG 776
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 801 NIPIISPKGERIPLSELAKISLEDGPTMIFRQEGRRTVTVRTNIRGRDQGGFVAELRQRVQKKIKLPEGYEIRYGGQYEN 880
Cdd:pfam00873 777 QLYVRNPYGKMIPLSAFAKIEWGYGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVKLPPGYGYTWTGQFEQ 856
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 881 LARVGTRLAIVIPLTVGIIFGVLYLLYKNLKYVYVALACIPLSLVGGIYALLLRGYYFNVSGGVGFISLFGIATMAGVLF 960
Cdd:pfam00873 857 EQLAGNSLPILIALALLVVFLVLAALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILM 936
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 961 VSRTNHlLHEDDEISVREAVKKAAVIQLRPMLMTILLALLGLIPATLASGVGSDVQRPLATVIVGGLFSALFLVLTVLPS 1040
Cdd:pfam00873 937 VEFANE-LREQEGKSLEEAILEACRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVPV 1015
|
....*
gi 446543436 1041 LYLIL 1045
Cdd:pfam00873 1016 FYVLF 1020
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
14-1045 |
2.50e-104 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 351.63 E-value: 2.50e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 14 VATLAASVGAIVFGIWAWIDIRKEAYSDIADTQVRLIAKFPGKAAVEVEERVTIPIERVLNAIPKVAVRRSRTINGLVVF 93
Cdd:NF033617 9 VATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQSSLGYSTI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 94 QFVFEDGTDdyfaRTRLLERVRDA------DIPSEVE-PTLGPMSSPVGEIYRYV-VESKAnhtpMELRTIQDW---NIM 162
Cdd:NF033617 89 TLQFRLGTD----LDVALSEVQAAinaaqsLLPSEAPdPPVYRKANSADTPIMYIgLTSEE----MPRGQLTDYaerVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 163 PKMLSIPGIADVVTFGGLPKQFHVVTTPDRLIRYKLTIEDVINAIQKNNLNTGGNLLLQGEQGFPIRSLGAIRTPEHIEN 242
Cdd:NF033617 161 PKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQLKTAEDYED 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 243 IVVK-TENGVPVFIRDLGSVEIShpipsgvlgytIQNDQ-EGLIDVDSSVqgLVAIRRWGDPNIM--GERIRAKVKEIND 318
Cdd:NF033617 241 LVIKyADNGAPVRLGDVATVELG-----------AENVRnRAWANGVPAV--VLGINRQPGANPIevADEIRALLPELQE 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 319 NyLPDGVQIRNTYDRTDLVNYTLRTIGKTLVEGVVVVSLVLIFFIGSIKASMVVVATIPFAMLFAFLLMNITGIPASLLS 398
Cdd:NF033617 308 T-LPKNIKVNVLYDRTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLT 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 399 LGA--IDFGIIVDGAVVMVENVMRRY-RDASPtdkkkgiVRFTVDAASEVGTEIIFSILIIILAYLPIFSFERIEGRLFK 475
Cdd:NF033617 387 LMAlvLAIGLVVDDAIVVVENIHRHIeEGESP-------LEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFR 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 476 PMAFTISFAILGALIFSMTAIPVLMSYIYRNYFESQNPGP-IEWhnpFYDWVERKYERLIEYLVERSKRVVVICFSIVGt 554
Cdd:NF033617 460 EFAVTLAGAVIISGIVALTLTPMMCSRLLKANEKPGRFARaVDR---FFDGLTARYGRGLKWVLKHRPLTLVVALATLA- 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 555 LLVAGGLSLGTEFLPEMDEGGFNLRIFFPVGISLPESRKFIPKIREMIYRNEQVN--VVLSQLGRNDDgtdplpPNRLEV 632
Cdd:NF033617 536 LLPLLYVFIPKELAPSEDRGVIFGMIQAPQSISLDYMSAKMRDVEKILSSDPEVQslTSFNGVGGNPG------DNTGFG 609
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 633 LVSLKDYNDwkEKITKQELLIRMRNDLeAGLPGARVsFSQPIMDNLSEAiMGTIADLAVFVSGNDLKIMRQIASEVLEIV 712
Cdd:NF033617 610 IINLKPWDE--RDVSAQEIIDRLRPKL-AKVPGMDL-FLFPLQDLPGGA-GSSLPQYQVTLTPSDYDSLFTWAEKLKEKL 684
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 713 KDMKGASEFGIEQEADSPQLTVRIDREAAARYGINVNDVQQMVEAAIGMQRIDTLYegpsdvppkTPAR-FGIVVRFSKD 791
Cdd:NF033617 685 RKSPQFADVDSDLQDKGPELNVDIDRDKAARLGISMQDIGSTLEVAFGQRQVNTIY---------TDGNqYKVVLEVDRR 755
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 792 YRSSKRAIENIPIISPKGERIPLSELAKISLEDGPTMIFRQEGRRTVTVRTNIRGRDQGGFVAELRQRVQKKIkLPEGYE 871
Cdd:NF033617 756 YRLNPEALNQIYVRSNDGKLVPLSTLAKIEERAAPLSLNHFNQFNSATLSFNLAPGVSLGEAIEALDQAAKEL-LPSGIS 834
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 872 IRYGGQYENLARVGTRLAIVIPLTVGIIFGVLYLLYKNLKYVYVALACIPLSLVGGIYALLLRGYYFNVSGGVGFISLFG 951
Cdd:NF033617 835 GSFQGAARAFQEEGSSLLFLFLLALAAIYLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIG 914
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 952 IATMAGVLFVSRTNHLlHEDDEISVREAVKKAAVIQLRPMLMTILLALLGLIPATLASGVGSDVQRPLATVIVGGLFSAL 1031
Cdd:NF033617 915 LVKKNGILMVEFANEL-QRHQGLSRREAIYQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGT 993
|
1050
....*....|....
gi 446543436 1032 FLVLTVLPSLYLIL 1045
Cdd:NF033617 994 LFTLFVLPVVYLLL 1007
|
|
| PRK09577 |
PRK09577 |
multidrug efflux RND transporter permease subunit; |
39-1047 |
3.21e-59 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169981 [Multi-domain] Cd Length: 1032 Bit Score: 221.65 E-value: 3.21e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 39 YSDIADTQVRLIAKFPGKAAVEVEERVTIPIERVLNAIPKVAVRRSRTINGLVVFQFVFEDGTDDYFARTRLLERVR--D 116
Cdd:PRK09577 35 YPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNGAPGLLYTSATSSAGQASLSLTFKQGVNADLAAVEVQNRLKtvE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 117 ADIPSEVEPTlGPMSSPVGEIYRYVVE---SKANHTPMELRTIQDWNIMPKMLSIPGIADVVTFGGlPKQFHVVTTPDRL 193
Cdd:PRK09577 115 ARLPEPVRRD-GIQVEKAADNIQLIVSltsDDGRLTGVELGEYASANVLQALRRVEGVGKVQFWGA-EYAMRIWPDPVKL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 194 IRYKLTIEDVINAIQKNNLN-TGGNLllqGEQGFP--------IRSLGAIRTPEHIENIVVKTE-NGVPVFIRDLGSVEI 263
Cdd:PRK09577 193 AALGLTASDIASAVRAHNARvTIGDI---GRSAVPdsapiaatVFADAPLKTPEDFGAIALRARaDGSALYLRDVARIEF 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 264 ShpipsgvlgytiQNDQEGLIDVDSSVQGLVAIRRWGDPNIMG--ERIRAKVKEINdNYLPDGVQIRNTYDRTDLVNYTL 341
Cdd:PRK09577 270 G------------GNDYNYPSYVNGKTATGMGIKLAPGSNAVAteKRVRATMDELS-RYFPPGVKYQIPYETSSFVRVSM 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 342 RTIGKTLVEGVVVVSLVLIFFIGSIKASMVVVATIPFAMLFAFLLMNITGIPASLLSL--GAIDFGIIVDGAVVMVENVM 419
Cdd:PRK09577 337 NKVVTTLIEAGVLVFLVMFLFMQNFRATLIPTLVVPVALLGTFGVMLAAGFSINVLTMfgMVLAIGILVDDAIVVVENVE 416
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 420 RRYRDA--SPTDKkkgivrfTVDAASEVGTEIIFSILIIILAYLPIFSFERIEGRLFKPMAFTISFAILGALIFSMTAIP 497
Cdd:PRK09577 417 RLMVEEglSPYDA-------TVKAMKQISGAIVGITVVLTSVFVPMAFFGGAVGNIYRQFALSLAVSIGFSAFLALSLTP 489
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 498 VLMSYIYRNYFESQNP--GPIEWHNPFYDWVERKYERLIEYLVERSKRVVVicfsIVGTLLVAGGL---SLGTEFLPEMD 572
Cdd:PRK09577 490 ALCATLLKPVDGDHHEkrGFFGWFNRFVARSTQRYATRVGAILKRPLRWLV----VYGALTAAAALlftRLPTAFLPDED 565
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 573 EGGFNLRIFFPVGISLPESRKFIPKIREMIYRNEQVNVVLSQLGRNDDGTDplpPNRLEVLVSLKDYNDWKEKITKQELL 652
Cdd:PRK09577 566 QGNFMVMVIRPQGTPLAETMQSVREVESYLRRHEPVAYTFALGGFNLYGEG---PNGGMIFVTLKDWKERKAARDHVQAI 642
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 653 IRMRNDLEAGLPGARV-SFSQPIMDNLSEAI--------MGTIaDLAVFVSGNDLKIMRQIASEVLEIVKdmkgaseFGI 723
Cdd:PRK09577 643 VARINERFAGTPNTTVfAMNSPALPDLGSTSgfdfrlqdRGGL-GYAAFVAAREQLLAEGAKDPALTDLM-------FAG 714
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 724 EQEAdsPQLTVRIDREAAARYGINVNDVQQMVEAAIGMQRIDTLYEGpsdvppkTPARfGIVVRFSKDYRSSKRAIENIP 803
Cdd:PRK09577 715 TQDA--PQLKLDIDRAKASALGVSMDEINTTLAVMFGSDYIGDFMHG-------SQVR-RVIVQADGRHRLDPDDVKKLR 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 804 IISPKGERIPLSELAKISLEDGPTMIFRQEGRRTVTVRTNIR-GRDQGGFVAELRQRVQkkiKLPEGYEIRYGGQYENLA 882
Cdd:PRK09577 785 VRNAQGEMVPLAAFATLHWTLGPPQLTRYNGYPSFTINGSAApGHSSGEAMAAIERIAA---TLPAGIGYAWSGQSFEER 861
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 883 RVGTRLAIVIPLTVGIIFGVLYLLYKNLKYVYVALACIPLSLVGGIYALLLRGYYFNVSGGVGFISLFGIATMAGVLFVS 962
Cdd:PRK09577 862 LSGAQAPMLFALSVLVVFLALAALYESWSIPFAVMLVVPLGVIGAVLGVTLRGMPNDIYFKVGLIATIGLSAKNAILIVE 941
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 963 RTNHLLheDDEISVREAVKKAAVIQLRPMLMTILLALLGLIPATLASGVGSDVQRPLATVIVGGLFSALFLVLTVLPsLY 1042
Cdd:PRK09577 942 VAKDLV--AQRMSLADAALEAARLRLRPIVMTSLAFGVGVLPLAFASGAASGAQIAIGTGVLGGVITATVLAVFLVP-LF 1018
|
....*
gi 446543436 1043 LILVG 1047
Cdd:PRK09577 1019 FVVVG 1023
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
1-1049 |
0e+00 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 1179.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 1 MIRNLLEGMMRFRVATLAASVGAIVFGIWAWIDIRKEAYSDIADTQVRLIAKFPGKAAVEVEERVTIPIERVLNAIPKVA 80
Cdd:COG3696 1 MLNRIIRFSLRNRLLVLLLTLLLAAAGIYSLRRLPIDAFPDITNVQVQVITEAPGLSPEEVEQQVTYPIETALNGLPGVK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 81 VRRSRTINGLVVFQFVFEDGTDDYFARTRLLERVRDA--DIPSEVEPTLGPMSSPVGEIYRYVVESKAN-HTPMELRTIQ 157
Cdd:COG3696 81 EVRSISRFGLSVVTVIFEDGTDIYWARQLVLERLQQVreQLPAGVTPELGPISTGLGEIYQYTLESDPGkYSLMELRTLQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 158 DWNIMPKMLSIPGIADVVTFGGLPKQFHVVTTPDRLIRYKLTIEDVINAIQKNNLNTGGNLLLQGEQGFPIRSLGAIRTP 237
Cdd:COG3696 161 DWVIRPQLRSVPGVAEVNSFGGFVKQYQVLVDPAKLRAYGLTLDDVIEALERNNANVGGGYIERGGQEYLVRGIGLIRSL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 238 EHIENIVVKTENGVPVFIRDLGSVEISHPIPSGVLGYtiqNDQeglidvDSSVQGLVAIRRWGDPNIMGERIRAKVKEIN 317
Cdd:COG3696 241 EDIENIVVKTRNGTPVLLRDVAEVRIGPAPRRGAATL---NGE------GEVVGGIVLMLKGENALEVIEAVKAKLAELK 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 318 dNYLPDGVQIRNTYDRTDLVNYTLRTIGKTLVEGVVVVSLVLIFFIGSIKASMVVVATIPFAMLFAFLLMNITGIPASLL 397
Cdd:COG3696 312 -PSLPEGVKIVPFYDRSDLIDRAIHTVTKNLLEGALLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLFGISANLM 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 398 SLG--AIDFGIIVDGAVVMVENVMRRYRDASPTDKKKGIVRFTVDAASEVGTEIIFSILIIILAYLPIFSFERIEGRLFK 475
Cdd:COG3696 391 SLGglAIDFGIIVDGAVVMVENILRRLEENRAAGTPRERLEVVLEAAREVRRPIFFATLIIILVFLPIFTLEGVEGKLFR 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 476 PMAFTISFAILGALIFSMTAIPVLMSYIYRNYFEsqnpgpiEWHNPFYDWVERKYERLIEYLVERSKRVVVICFSIVGTL 555
Cdd:COG3696 471 PMALTVIFALLGALLLSLTLVPVLASLLLRGKVP-------EKENPLVRWLKRLYRPLLRWALRHPKLVLAVALVLLVLA 543
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 556 LVAGgLSLGTEFLPEMDEGGFNLRIFFPVGISLPESRKFIPKIREMIYRNEQVNVVLSQLGRNDDGTDPLPPNRLEVLVS 635
Cdd:COG3696 544 LALF-PRLGSEFLPELDEGDLLVMATLPPGISLEESVELGQQVERILKSFPEVESVVSRTGRAEDATDPMGVNMSETFVI 622
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 636 LKDYNDWKEKITKQELLIRMRNDLEaGLPGARVSFSQPIMDNLSEAIMGTIADLAVFVSGNDLKIMRQIASEVLEIVKDM 715
Cdd:COG3696 623 LKPRSEWRSGRTKEELIAEMREALE-QIPGVNFNFSQPIQMRVDELLSGVRADVAVKIFGDDLDVLRRLAEQIEAVLKTV 701
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 716 KGASEFGIEQEADSPQLTVRIDREAAARYGINVNDVQQMVEAAIGMQRIDTLYEGPsdvppktpARFGIVVRFSKDYRSS 795
Cdd:COG3696 702 PGAADVQVERVTGLPQLDIRIDRDAAARYGLNVADVQDVVETAIGGKAVGQVYEGE--------RRFDIVVRLPEELRDD 773
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 796 KRAIENIPIISPKGERIPLSELAKISLEDGPTMIFRQEGRRTVTVRTNIRGRDQGGFVAELRQRVQKKIKLPEGYEIRYG 875
Cdd:COG3696 774 PEAIRNLPIPTPSGAQVPLSQVADIEVVEGPNQISRENGRRRIVVQANVRGRDLGSFVAEAQAKVAEQVKLPPGYYIEWG 853
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 876 GQYENLARVGTRLAIVIPLTVGIIFGVLYLLYKNLKYVYVALACIPLSLVGGIYALLLRGYYFNVSGGVGFISLFGIATM 955
Cdd:COG3696 854 GQFENLQRATARLAIVVPLALLLIFLLLYLAFGSVRDALLILLNVPFALIGGVLALWLRGMPLSVSAGVGFIALFGVAVL 933
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 956 AGVLFVSRTNHLLHEDdeISVREAVKKAAVIQLRPMLMTILLALLGLIPATLASGVGSDVQRPLATVIVGGLFSALFLVL 1035
Cdd:COG3696 934 NGVVLVSYINQLRAEG--LDLREAIIEGALERLRPVLMTALVAALGLLPMALSTGPGSEVQRPLATVVIGGLITSTLLTL 1011
|
1050
....*....|....
gi 446543436 1036 TVLPSLYLILVGER 1049
Cdd:COG3696 1012 LVLPALYLLFGRRR 1025
|
|
| 2A0601 |
TIGR00914 |
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ... |
1-1056 |
0e+00 |
|
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129992 [Multi-domain] Cd Length: 1051 Bit Score: 749.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 1 MIRNLLEGMMRFRVATLAASVGAIVFGIWAWIDIRKEAYSDIADTQVRLIAKFPGKAAVEVEERVTIPIERVLNAIPKVA 80
Cdd:TIGR00914 1 MIERIISFSVAQRWLVLLATLVMAILGIWSYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 81 VRRSRTINGLVVFQFVFEDGTDDYFARTRLLERVRDA--DIPSEVEPTLGPMSSPVGEIYRYVVESKAN--------HTP 150
Cdd:TIGR00914 81 TTRSLSRYGLSQVTVIFKDGTDLYFARQLVNERLQQArdNLPEGVSPEMGPISTGLGEIFLYTVEAEEGarkkdggaYTL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 151 MELRTIQDWNIMPKMLSIPGIADVVTFGGLPKQFHVVTTPDRLIRYKLTIEDVINAIQKNNLNTGGNLLLQGEQGFPIRS 230
Cdd:TIGR00914 161 TDLRTIQDWIIRPQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVRA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 231 LGAIRTPEHIENIVVKTENGVPVFIRDLGSVEISHPIPSGVlgyTIQNDQEglidvdsSVQGLVAIRRWGDPNIMGERIR 310
Cdd:TIGR00914 241 PGQVQSMDDIRNIVIATGEGVPIRIRDVARVQIGKELRTGA---ATENGKE-------VVLGTVFMLIGENSRTVAQAVG 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 311 AKVKEINDNyLPDGVQIRNTYDRTDLVNYTLRTIGKTLVEGVVVVSLVLIFFIGSIKASMVVVATIPFAMLFAFLLMNIT 390
Cdd:TIGR00914 311 DKLETINKT-LPEGVEIVTTYDRSQLVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPLSLLITFIGMVFQ 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 391 GIPASLLSLGAIDFGIIVDGAVVMVENVMRR-----YRDASPTDKKKgivRFTV--DAASEVGTEIIFSILIIILAYLPI 463
Cdd:TIGR00914 390 GISANLMSLGALDFGLIVDGAVVIVENAHRRlaeaqHHHGRQLTLKE---RLHEvfAASREVRRPLIFGQLIITLVFLPI 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 464 FSFERIEGRLFKPMAFTISFAILGALIFSMTAIPVLMSYIYRNYFEsqnpgpiEWHNPFYDWVERKYERLIEYLVERSKr 543
Cdd:TIGR00914 467 FTLTGVEGKMFHPMAFTVVLALAGAMILSLTFVPAAVALFIRGKVA-------EKENRLMRVLKRRYEPLLERVLAWPA- 538
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 544 vVVICFSIVGTLLVAGGLS-LGTEFLPEMDEGGFNLRIFFPVGISLPESRKFIPKIREMIYRNEQVNVVLSQLGRNDDGT 622
Cdd:TIGR00914 539 -VVLGAAAVSIVLVVWIASrVGGEFIPSLNEGDLAYQALRIPGTSLAQSVAMQQTLEKLIKSFPEVARVFAKTGTAEIAT 617
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 623 DPLPPNRLEVLVSLKDYNDWKE-KITKQELLIRMRnDLEAGLPGARVSFSQPIMDNLSEAIMGTIADLAVFVSGNDLKIM 701
Cdd:TIGR00914 618 DPMPPNASDTYIILKPESQWPEgKKTKEDLIEEIQ-EATVRIPGNNYEFTQPIQMRFNELISGVRSDVAVKVFGDDLDDL 696
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 702 RQIASEVLEIVKDMKGASEFGIEQEADSPQLTVRIDREAAARYGINVNDVQQMVEAAIGMQRIDTLYEGPsdvppktpAR 781
Cdd:TIGR00914 697 DATAEKISAVLKGVPGAADVKVEQTTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETFEGD--------RR 768
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 782 FGIVVRFSKDYRSSKRAIENIPIISPKGE-----RIPLSELAKISLEDGPTMIFRQEGRRTVTVRTNIRGRDQGGFVAEL 856
Cdd:TIGR00914 769 FDIVIRLPESLRESPQALRQLPIPLPLSEdarkqFIPLSDVADLRVSPGPNQISRENGKRRVVVSANVRGRDLGSFVDDA 848
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 857 RQRVQKKIKLPEGYEIRYGGQYENLARVGTRLAIVIPLTVGIIFGVLYLLYKNLKYVYVALACIPLSLVGGIYALLLRGY 936
Cdd:TIGR00914 849 KKAIAEQVKLPPGYWITWGGQFEQLQSATKRLQIVVPVTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALWLRGI 928
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 937 YFNVSGGVGFISLFGIATMAGVLFVSRTNHLLheDDEISVREAVKKAAVIQLRPMLMTILLALLGLIPATLASGVGSDVQ 1016
Cdd:TIGR00914 929 PLSISAAVGFIALSGVAVLNGLVMISFIRKLL--EEGPSLDEAVYEGALTRVRPVLMTALVASLGFVPMAIATGTGAEVQ 1006
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|
gi 446543436 1017 RPLATVIVGGLFSALFLVLTVLPSLYLILVGERDYVPKKQ 1056
Cdd:TIGR00914 1007 RPLATVVIGGIITATLLTLFVLPALYRLVHRRRHKGRKEH 1046
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
13-1045 |
0e+00 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 677.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 13 RVATLAASVGAIVFGIWAWIDIRKEAYSDIADTQVRLIAKFPGKAAVEVEERVTIPIERVLNAIPKVAVRRSRTINGLVV 92
Cdd:pfam00873 9 PIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSSQSSYGLSS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 93 FQFVFEDGTDDYFARTRLLERVRDA--DIPSEV-EPTLGPMSSPVGEIYRYVVESKAN-HTPMELRTIQDWNIMPKMLSI 168
Cdd:pfam00873 89 ITLTFELGTDIDIARQDVQNRLQLAtpLLPEGVqRPGISVIKTSLGPIMVLAVTSPDGsYTQTDLRDYADTNIKPQLSRV 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 169 PGIADVVTFGGLPKQFHVVTTPDRLIRYKLTIEDVINAIQKNNLNTGGNLLLQGEQGFPIRSLGAIRTPEHIENIVVKTE 248
Cdd:pfam00873 169 PGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAEDFEKIIVKNQ 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 249 NGVPVFIRDLGSVEIshpipsGVLGYTI---QNDQEGLidvdssvqgLVAIRRWGDPNIM--GERIRAKVKEINDnYLPD 323
Cdd:pfam00873 249 DGSPVRLRDVATVEL------GSELYRGfatFNGKPAV---------GLGVQKLPGANAIetADAVRAKLAELKP-TFPQ 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 324 GVQIRNTYDRTDLVNYTLRTIGKTLVEGVVVVSLVLIFFIGSIKASMVVVATIPFAMLFAFLLMNITGIPASLLSLGAID 403
Cdd:pfam00873 313 GVEIVVVYDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLV 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 404 F--GIIVDGAVVMVENVMRRYRdASPTDKKKGIVRftvdAASEVGTEIIFSILIIILAYLPIFSFERIEGRLFKPMAFTI 481
Cdd:pfam00873 393 LaiGLVVDDAIVVVENIERVLE-ENGLKPLEAAYK----SMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITI 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 482 SFAILGALIFSMTAIPVLMSYIYRNYFESQNPGPIEWHNPFYDWVERKYERLIEYLVERSKRVVVICFSIVGtLLVAGGL 561
Cdd:pfam00873 468 VLAILLSVLVALTLTPALCATLLKPRREPKHGGFFRWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVV-GSVWLFV 546
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 562 SLGTEFLPEMDEGGFNLRIFFPVGISLPESRKFIPKIREMIYRNEQVNVVLSQLGRNDDGtDPLPPNRLEVLVSLKDYND 641
Cdd:pfam00873 547 RIPTEFLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFAFSG-DNNGPNSGDAFISLKPWKE 625
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 642 WK-EKITKQELLIRMRNDLEAgLPGARVSFSQPIMDNLSEAIMGTIADLAVFVSGNDLKIMRQIASEVLEIVKDMKGASE 720
Cdd:pfam00873 626 RPgPEKSVQALIERLRKALKQ-IPGANVFLFQPIQLRGLGTISGFRSDLQVKIFGDDLDALDEARNQILAALAQLPGLSD 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 721 FGIEQEADSPQLTVRIDREAAARYGINVNDVQQMVEAAIGMQRIDTLYEGPSdvppktpaRFGIVVRFSKDYRSSKRAIE 800
Cdd:pfam00873 705 VRSDGQEDQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGR--------VYDVVVQLPEDFRSSPEDIG 776
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 801 NIPIISPKGERIPLSELAKISLEDGPTMIFRQEGRRTVTVRTNIRGRDQGGFVAELRQRVQKKIKLPEGYEIRYGGQYEN 880
Cdd:pfam00873 777 QLYVRNPYGKMIPLSAFAKIEWGYGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVKLPPGYGYTWTGQFEQ 856
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 881 LARVGTRLAIVIPLTVGIIFGVLYLLYKNLKYVYVALACIPLSLVGGIYALLLRGYYFNVSGGVGFISLFGIATMAGVLF 960
Cdd:pfam00873 857 EQLAGNSLPILIALALLVVFLVLAALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILM 936
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 961 VSRTNHlLHEDDEISVREAVKKAAVIQLRPMLMTILLALLGLIPATLASGVGSDVQRPLATVIVGGLFSALFLVLTVLPS 1040
Cdd:pfam00873 937 VEFANE-LREQEGKSLEEAILEACRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVPV 1015
|
....*
gi 446543436 1041 LYLIL 1045
Cdd:pfam00873 1016 FYVLF 1020
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
4-1045 |
0e+00 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 599.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 4 NLLEGMMRFRVATLAASVGAIVFGIWAWIDIRKEAYSDIADTQVRLIAKFPGKAAVEVEERVTIPIERVLNAIPKVAVRR 83
Cdd:COG0841 2 NLSRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYIT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 84 SRTINGLVVFQFVFEDGTDdyfaRTRLLERVRDA------DIPSEVEP----TLGPMSSPvgeIYRYVVESKaNHTPMEL 153
Cdd:COG0841 82 STSSEGSSSITVEFELGTD----IDEALVDVQNAvdrarsDLPEDVEPpgvtKVNPSDFP---VMVLALSSD-DLDELEL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 154 RTIQDWNIMPKMLSIPGIADVVTFGGLPKQFHVVTTPDRLIRYKLTIEDVINAIQKNNLNTGGNLLLQGEQGFPIRSLGA 233
Cdd:COG0841 154 SDYAERNIKDRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 234 IRTPEHIENIVVKTENGVPVFIRDLGSVEISHPIPSgvlGYTIQNDQEGLidvdssvqgLVAIRRWGDPNI--MGERIRA 311
Cdd:COG0841 234 LKTPEEFENIVIRTNDGSVVRLGDVARVEDGAEDYR---SIARLNGKPAV---------GLAIQKQPGANAleVADAVRA 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 312 KVKEINDNyLPDGVQIRNTYDRTDLVNYTLRTIGKTLVEGVVVVSLVLIFFIGSIKASMVVVATIPFAMLFAFLLMNITG 391
Cdd:COG0841 302 KLEELQAS-LPEGVELTIVYDQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLG 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 392 IPASLLSLGAIDF--GIIVDGAVVMVENVMRRYRdasptdKKKGIVRFTVDAASEVGTEIIFSILIIILAYLPIFSFERI 469
Cdd:COG0841 381 FSLNILTLFALVLaiGIVVDDAIVVVENIERHME------EGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGI 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 470 EGRLFKPMAFTISFAILGALIFSMTAIPVLMSYIYRNYFESQNPGPIEWHNPFYDWVERKYERLIEYLVERSKRVVVIcf 549
Cdd:COG0841 455 TGQLFRQFALTVAIALLISLFVALTLTPALCARLLKPHPKGKKGRFFRAFNRGFDRLTRGYGRLLRWALRHRKLTLLV-- 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 550 sIVGTLLVAGGL--SLGTEFLPEMDEGGFNLRIFFPVGISLPESRKFIPKIREMIYRNEQVNVVLSQLGRNDDGTDplpP 627
Cdd:COG0841 533 -ALALLALSVLLfgRLPTEFFPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSGGGSG---S 608
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 628 NRLEVLVSLKdynDWKE-KITKQELLIRMRNDLeAGLPGARVSFSQPIMDNLseaimGTIADLAVFVSGNDLKIMRQIAS 706
Cdd:COG0841 609 NSGTIFVTLK---PWDErDRSADEIIARLREKL-AKIPGARVFVFQPPAGGL-----GSGAPIEVQLQGDDLEELAAAAE 679
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 707 EVLEIVKDMKGASEFGIEQEADSPQLTVRIDREAAARYGINVNDVQQMVEAAIGMQRIDTLYEGPSDVPpktparfgIVV 786
Cdd:COG0841 680 KLLAALRQIPGLVDVRSDLQLGKPELQLDIDREKAAALGVTVADVASTLRAALGGRYVNDFNRGGREYD--------VRV 751
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 787 RFSKDYRSSKRAIENIPIISPKGERIPLSELAKISLEDGPTMIFRQEGRRTVTVRTNI-RGRDQGGFVAELRQRVqKKIK 865
Cdd:COG0841 752 QAPEEDRNSPEDLENLYVRTPDGEMVPLSSVATIEEGTGPSSINRYNGQRSVTVSANLaPGVSLGEALAAIEELA-AELK 830
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 866 LPEGYEIRYGGQYENLARVGTRLAIVIPLTVGIIFGVLYLLYKNLKYVYVALACIPLSLVGGIYALLLRGYYFNVSGGVG 945
Cdd:COG0841 831 LPPGVSIEFTGQAEEEQESFSSLGLAFLLALLLVYLVLAAQFESFIQPLIILLTVPLALIGALLGLLLTGTPLNIYSQIG 910
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 946 FISLFGIATMAGVLFVSRTNHLLHEDdeISVREAVKKAAVIQLRPMLMTILLALLGLIPATLASGVGSDVQRPLATVIVG 1025
Cdd:COG0841 911 LIMLIGIVVKNAILLVDFANQLREEG--MSLREAILEAARLRLRPILMTSLATILGLLPLALGTGAGAEFRQPLGIAVIG 988
|
1050 1060
....*....|....*....|
gi 446543436 1026 GLFSALFLVLTVLPSLYLIL 1045
Cdd:COG0841 989 GLLFSTLLTLFVVPVLYVLL 1008
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
14-1045 |
2.50e-104 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 351.63 E-value: 2.50e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 14 VATLAASVGAIVFGIWAWIDIRKEAYSDIADTQVRLIAKFPGKAAVEVEERVTIPIERVLNAIPKVAVRRSRTINGLVVF 93
Cdd:NF033617 9 VATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQSSLGYSTI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 94 QFVFEDGTDdyfaRTRLLERVRDA------DIPSEVE-PTLGPMSSPVGEIYRYV-VESKAnhtpMELRTIQDW---NIM 162
Cdd:NF033617 89 TLQFRLGTD----LDVALSEVQAAinaaqsLLPSEAPdPPVYRKANSADTPIMYIgLTSEE----MPRGQLTDYaerVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 163 PKMLSIPGIADVVTFGGLPKQFHVVTTPDRLIRYKLTIEDVINAIQKNNLNTGGNLLLQGEQGFPIRSLGAIRTPEHIEN 242
Cdd:NF033617 161 PKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQLKTAEDYED 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 243 IVVK-TENGVPVFIRDLGSVEIShpipsgvlgytIQNDQ-EGLIDVDSSVqgLVAIRRWGDPNIM--GERIRAKVKEIND 318
Cdd:NF033617 241 LVIKyADNGAPVRLGDVATVELG-----------AENVRnRAWANGVPAV--VLGINRQPGANPIevADEIRALLPELQE 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 319 NyLPDGVQIRNTYDRTDLVNYTLRTIGKTLVEGVVVVSLVLIFFIGSIKASMVVVATIPFAMLFAFLLMNITGIPASLLS 398
Cdd:NF033617 308 T-LPKNIKVNVLYDRTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLT 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 399 LGA--IDFGIIVDGAVVMVENVMRRY-RDASPtdkkkgiVRFTVDAASEVGTEIIFSILIIILAYLPIFSFERIEGRLFK 475
Cdd:NF033617 387 LMAlvLAIGLVVDDAIVVVENIHRHIeEGESP-------LEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFR 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 476 PMAFTISFAILGALIFSMTAIPVLMSYIYRNYFESQNPGP-IEWhnpFYDWVERKYERLIEYLVERSKRVVVICFSIVGt 554
Cdd:NF033617 460 EFAVTLAGAVIISGIVALTLTPMMCSRLLKANEKPGRFARaVDR---FFDGLTARYGRGLKWVLKHRPLTLVVALATLA- 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 555 LLVAGGLSLGTEFLPEMDEGGFNLRIFFPVGISLPESRKFIPKIREMIYRNEQVN--VVLSQLGRNDDgtdplpPNRLEV 632
Cdd:NF033617 536 LLPLLYVFIPKELAPSEDRGVIFGMIQAPQSISLDYMSAKMRDVEKILSSDPEVQslTSFNGVGGNPG------DNTGFG 609
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 633 LVSLKDYNDwkEKITKQELLIRMRNDLeAGLPGARVsFSQPIMDNLSEAiMGTIADLAVFVSGNDLKIMRQIASEVLEIV 712
Cdd:NF033617 610 IINLKPWDE--RDVSAQEIIDRLRPKL-AKVPGMDL-FLFPLQDLPGGA-GSSLPQYQVTLTPSDYDSLFTWAEKLKEKL 684
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 713 KDMKGASEFGIEQEADSPQLTVRIDREAAARYGINVNDVQQMVEAAIGMQRIDTLYegpsdvppkTPAR-FGIVVRFSKD 791
Cdd:NF033617 685 RKSPQFADVDSDLQDKGPELNVDIDRDKAARLGISMQDIGSTLEVAFGQRQVNTIY---------TDGNqYKVVLEVDRR 755
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 792 YRSSKRAIENIPIISPKGERIPLSELAKISLEDGPTMIFRQEGRRTVTVRTNIRGRDQGGFVAELRQRVQKKIkLPEGYE 871
Cdd:NF033617 756 YRLNPEALNQIYVRSNDGKLVPLSTLAKIEERAAPLSLNHFNQFNSATLSFNLAPGVSLGEAIEALDQAAKEL-LPSGIS 834
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 872 IRYGGQYENLARVGTRLAIVIPLTVGIIFGVLYLLYKNLKYVYVALACIPLSLVGGIYALLLRGYYFNVSGGVGFISLFG 951
Cdd:NF033617 835 GSFQGAARAFQEEGSSLLFLFLLALAAIYLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIG 914
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 952 IATMAGVLFVSRTNHLlHEDDEISVREAVKKAAVIQLRPMLMTILLALLGLIPATLASGVGSDVQRPLATVIVGGLFSAL 1031
Cdd:NF033617 915 LVKKNGILMVEFANEL-QRHQGLSRREAIYQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGT 993
|
1050
....*....|....
gi 446543436 1032 FLVLTVLPSLYLIL 1045
Cdd:NF033617 994 LFTLFVLPVVYLLL 1007
|
|
| 2A0602 |
TIGR00915 |
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ... |
19-1047 |
2.85e-68 |
|
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]
Pssm-ID: 273335 [Multi-domain] Cd Length: 1044 Bit Score: 249.26 E-value: 2.85e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 19 ASVGAIVF---GIWAWIDIRKEAYSDIADTQVRLIAKFPGKAAVEVEERVTIPIERVLNAIPKVAVRRSRTIN-GLVVFQ 94
Cdd:TIGR00915 12 AWVIAIIImlaGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSSSSDSdGSMTIT 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 95 FVFEDGTDDYFARTRLLERVRDAD--IPSEVEPTlGPMSSPVGEIYRYVVESKANHTPMELRTIQDW---NIMPKMLSIP 169
Cdd:TIGR00915 92 LTFEQGTDPDIAQVQVQNKLQLATplLPQEVQRQ-GVRVEKASSNFLMVIGLVSDDGSMTKEDLSDYaasNMVDPLSRLE 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 170 GIADVVTFGGlPKQFHVVTTPDRLIRYKLTIEDVINAIQKNNLNT-----GGNLLLQGEQ-GFPIRSLGAIRTPEHIENI 243
Cdd:TIGR00915 171 GVGDVQLFGS-QYAMRIWLDPAKLNSYQLTPADVISAISAQNAQIsagqlGGLPAVPGQQlNATIIAQTRLQTPEQFENI 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 244 VVKT-ENGVPVFIRDLGSVEIshpipsGVLGYTIQNDQEGlidvdSSVQGLvAIRRWGDPNIM--GERIRAKVKEInDNY 320
Cdd:TIGR00915 250 LLKVnTDGSQVRLKDVARVEL------GGENYSISARFNG-----KPASGL-AIKLATGANALdtAKAVKAELAVL-EPF 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 321 LPDGVQIRNTYDRTDLVNYTLRTIGKTLVEGVVVVSLVLIFFIGSIKASMVVVATIPFAMLFAFLLMNITGIPASLLSLG 400
Cdd:TIGR00915 317 FPQGMKYVYPYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMF 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 401 A--IDFGIIVDGAVVMVENVMRRYRDA--SP---TDKKKGIVRFTVDAASEVgteiifsiliIILAYLPIFSFERIEGRL 473
Cdd:TIGR00915 397 AmvLAIGLLVDDAIVVVENVERVMAEEglPPkeaTRKSMGQIQGALVGIAMV----------LSAVFVPMAFFGGSTGAI 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 474 FKPMAFTISFAI----LGALIFSMTAIPVLMSYIYRNYFESQNPGPIEWHNPFYDWVERKYERLIEYLVERSKRVVVICF 549
Cdd:TIGR00915 467 YRQFSITIVSAMalsvLVALILTPALCATMLKPIEKGEHHEKKGGFFGWFNRMFDSSTHGYENGVGKILRRRGRYLLVYV 546
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 550 sivgtLLVAGG----LSLGTEFLPEMDEGGFNLRIFFPVGISLPESRKFIPKIREMIYRNEQVNV--VLSQLGRNDDGTD 623
Cdd:TIGR00915 547 -----LLVGGMvflfVRLPTSFLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKYLLAKEKANVesVFTVNGFSFAGRG 621
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 624 plpPNRLEVLVSLKDYNDWKEKITKQELLIRMRNDLEAGLPGARV-SFSQPimdnlseAI--MGTIADLAVFV---SGND 697
Cdd:TIGR00915 622 ---QNMGMAFIRLKDWEERTGKENSVFAIAGRATGHFMQIKDAMViAFVPP-------AIleLGNATGFDFFLqdrAGLG 691
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 698 LKIMRQIASEVLEIVKDMKGASEFGIEQEADSPQLTVRIDREAAARYGINVNDVQQMVEAAIGMQRI-DTLYEGpsdvpp 776
Cdd:TIGR00915 692 HEALLQARNQLLGLAAQNPALTRVRPNGLEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVnDFIDRG------ 765
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 777 ktpaRFGIV-VRFSKDYRSSKRAIENIPIISPKGERIPLSELAKISLEDGPTMIFRQEGRRTVtvrtNIRGRDQGGF--- 852
Cdd:TIGR00915 766 ----RVKRVyVQAEEDARMSPEDINKWYVRNASGEMVPFSAFATVRWEYGSPQLERYNGLPSM----EILGSAAPGVstg 837
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 853 --VAELRQRVQkkiKLPEGYEIRYGGQYENLARVGTRLAIVIPLTVGIIFGVLYLLYKNLKYVYVALACIPLSLVGGIYA 930
Cdd:TIGR00915 838 qaMAAMEAIAQ---KLPPGFGFSWTGMSYEERLSGSQAPALYALSLLVVFLCLAALYESWSIPVSVMLVVPLGIIGALLA 914
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 931 LLLRGYYFNVSGGVGFISLFGIATMAGVLFVSRTNHlLHEDDEiSVREAVKKAAVIQLRPMLMTILLALLGLIPATLASG 1010
Cdd:TIGR00915 915 TTLRGLSNDVYFQVGLLTTIGLSAKNAILIVEFAKE-LMAQGK-SIVEAALEAARLRLRPILMTSLAFILGVVPLAISTG 992
|
1050 1060 1070
....*....|....*....|....*....|....*..
gi 446543436 1011 VGSDVQRPLATVIVGGLFSALFLVLTVLPSLYLILVG 1047
Cdd:TIGR00915 993 AGSGSQHAIGTGVFGGMVTATVLAIFFVPLFYVVVRR 1029
|
|
| PRK09577 |
PRK09577 |
multidrug efflux RND transporter permease subunit; |
39-1047 |
3.21e-59 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169981 [Multi-domain] Cd Length: 1032 Bit Score: 221.65 E-value: 3.21e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 39 YSDIADTQVRLIAKFPGKAAVEVEERVTIPIERVLNAIPKVAVRRSRTINGLVVFQFVFEDGTDDYFARTRLLERVR--D 116
Cdd:PRK09577 35 YPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNGAPGLLYTSATSSAGQASLSLTFKQGVNADLAAVEVQNRLKtvE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 117 ADIPSEVEPTlGPMSSPVGEIYRYVVE---SKANHTPMELRTIQDWNIMPKMLSIPGIADVVTFGGlPKQFHVVTTPDRL 193
Cdd:PRK09577 115 ARLPEPVRRD-GIQVEKAADNIQLIVSltsDDGRLTGVELGEYASANVLQALRRVEGVGKVQFWGA-EYAMRIWPDPVKL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 194 IRYKLTIEDVINAIQKNNLN-TGGNLllqGEQGFP--------IRSLGAIRTPEHIENIVVKTE-NGVPVFIRDLGSVEI 263
Cdd:PRK09577 193 AALGLTASDIASAVRAHNARvTIGDI---GRSAVPdsapiaatVFADAPLKTPEDFGAIALRARaDGSALYLRDVARIEF 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 264 ShpipsgvlgytiQNDQEGLIDVDSSVQGLVAIRRWGDPNIMG--ERIRAKVKEINdNYLPDGVQIRNTYDRTDLVNYTL 341
Cdd:PRK09577 270 G------------GNDYNYPSYVNGKTATGMGIKLAPGSNAVAteKRVRATMDELS-RYFPPGVKYQIPYETSSFVRVSM 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 342 RTIGKTLVEGVVVVSLVLIFFIGSIKASMVVVATIPFAMLFAFLLMNITGIPASLLSL--GAIDFGIIVDGAVVMVENVM 419
Cdd:PRK09577 337 NKVVTTLIEAGVLVFLVMFLFMQNFRATLIPTLVVPVALLGTFGVMLAAGFSINVLTMfgMVLAIGILVDDAIVVVENVE 416
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 420 RRYRDA--SPTDKkkgivrfTVDAASEVGTEIIFSILIIILAYLPIFSFERIEGRLFKPMAFTISFAILGALIFSMTAIP 497
Cdd:PRK09577 417 RLMVEEglSPYDA-------TVKAMKQISGAIVGITVVLTSVFVPMAFFGGAVGNIYRQFALSLAVSIGFSAFLALSLTP 489
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 498 VLMSYIYRNYFESQNP--GPIEWHNPFYDWVERKYERLIEYLVERSKRVVVicfsIVGTLLVAGGL---SLGTEFLPEMD 572
Cdd:PRK09577 490 ALCATLLKPVDGDHHEkrGFFGWFNRFVARSTQRYATRVGAILKRPLRWLV----VYGALTAAAALlftRLPTAFLPDED 565
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 573 EGGFNLRIFFPVGISLPESRKFIPKIREMIYRNEQVNVVLSQLGRNDDGTDplpPNRLEVLVSLKDYNDWKEKITKQELL 652
Cdd:PRK09577 566 QGNFMVMVIRPQGTPLAETMQSVREVESYLRRHEPVAYTFALGGFNLYGEG---PNGGMIFVTLKDWKERKAARDHVQAI 642
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 653 IRMRNDLEAGLPGARV-SFSQPIMDNLSEAI--------MGTIaDLAVFVSGNDLKIMRQIASEVLEIVKdmkgaseFGI 723
Cdd:PRK09577 643 VARINERFAGTPNTTVfAMNSPALPDLGSTSgfdfrlqdRGGL-GYAAFVAAREQLLAEGAKDPALTDLM-------FAG 714
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 724 EQEAdsPQLTVRIDREAAARYGINVNDVQQMVEAAIGMQRIDTLYEGpsdvppkTPARfGIVVRFSKDYRSSKRAIENIP 803
Cdd:PRK09577 715 TQDA--PQLKLDIDRAKASALGVSMDEINTTLAVMFGSDYIGDFMHG-------SQVR-RVIVQADGRHRLDPDDVKKLR 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 804 IISPKGERIPLSELAKISLEDGPTMIFRQEGRRTVTVRTNIR-GRDQGGFVAELRQRVQkkiKLPEGYEIRYGGQYENLA 882
Cdd:PRK09577 785 VRNAQGEMVPLAAFATLHWTLGPPQLTRYNGYPSFTINGSAApGHSSGEAMAAIERIAA---TLPAGIGYAWSGQSFEER 861
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 883 RVGTRLAIVIPLTVGIIFGVLYLLYKNLKYVYVALACIPLSLVGGIYALLLRGYYFNVSGGVGFISLFGIATMAGVLFVS 962
Cdd:PRK09577 862 LSGAQAPMLFALSVLVVFLALAALYESWSIPFAVMLVVPLGVIGAVLGVTLRGMPNDIYFKVGLIATIGLSAKNAILIVE 941
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 963 RTNHLLheDDEISVREAVKKAAVIQLRPMLMTILLALLGLIPATLASGVGSDVQRPLATVIVGGLFSALFLVLTVLPsLY 1042
Cdd:PRK09577 942 VAKDLV--AQRMSLADAALEAARLRLRPIVMTSLAFGVGVLPLAFASGAASGAQIAIGTGVLGGVITATVLAVFLVP-LF 1018
|
....*
gi 446543436 1043 LILVG 1047
Cdd:PRK09577 1019 FVVVG 1023
|
|
| PRK09579 |
PRK09579 |
multidrug efflux RND transporter permease subunit; |
10-1045 |
9.73e-58 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169983 [Multi-domain] Cd Length: 1017 Bit Score: 217.01 E-value: 9.73e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 10 MRFRVATLAASVGAIVFGIWAWIDIRKEAYSDIADTQVRLIAKFPGKAAVEVEERVTIPIERVLNAIPKVAVRRSRTING 89
Cdd:PRK09579 8 IRRPVLASVVSLLIVLLGFQAWSKLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYMTSVSRQN 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 90 LVVFQFVFEDGTDDYFARTRLLERVRDA--DIPSEVE-PTLGPMSSPVGEIYRYVVESKANHTPMelrtIQDW---NIMP 163
Cdd:PRK09579 88 FSIISIYARIGADSDRLFTELLAKANEVknQLPQDAEdPVLSKEAADASALMYISFYSEEMSNPQ----ITDYlsrVIQP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 164 KMLSIPGIADVVTFGGLPKQFHVVTTPDRLIRYKLTIEDVINAIQKNN-LNTGGNLllQGEqgFPIRSLGA---IRTPEH 239
Cdd:PRK09579 164 KLATLPGMAEAEILGNQVFAMRLWLDPVKLAGFGLSAGDVTQAVRRYNfLSAAGEV--KGE--YVVTSINAsteLKSAEA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 240 IENIVVKTENGVPVFIRDLGSVEIshpipsGVLGYTIQNDQEGLIDVDSSVQGLVAirrwGDPNIMGERIRAKVKEINDN 319
Cdd:PRK09579 240 FAAIPVKTSGDSRVLLGDVARVEM------GAENYDSISSFDGIPSVYIGIKATPS----ANPLDVIKEVRAIMPELESQ 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 320 yLPDGVQIRNTYDRTDLVNYTLRTIGKTLVEGVVVVSLVLIFFIGSIKASMVVVATIPFAMLFAFLLMNITGIPASLLSL 399
Cdd:PRK09579 310 -LPPNLKVSIAYDATLFIQASIDEVVKTLGEAVLIVIVVVFLFLGALRSVLIPVVTIPLSMIGVLFFMQMMGYSINLLTL 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 400 GA--IDFGIIVDGAVVMVENVMRRYRDA-SPTDKkkgivrfTVDAASEVGTEIIFSILIIILAYLPIFSFERIEGRLFKP 476
Cdd:PRK09579 389 LAmvLAIGLVVDDAIVVVENIHRHIEEGkSPFDA-------ALEGAREIAMPVVSMTITLAAVYAPIGFLTGLTGALFKE 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 477 MAFTISFAILGALIFSMTAIPVLMSYIYRNyfeSQNP-GPIEWHNPFYDWVERKYERLIEYLVErsKRVVVICFSIVGTL 555
Cdd:PRK09579 462 FALTLAGAVIISGIVALTLSPMMCALLLRH---EENPsGLAHRLDRLFERLKQRYQRALHGTLN--TRPVVLVFAVIVLA 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 556 LVAGGLSLG-TEFLPEMDEGGFNLRIFFPVGISL----PESRKFIPKIREM--IYRNEQVNvvlsqlgrnddGTDPLPPN 628
Cdd:PRK09579 537 LIPVLLKFTqSELAPEEDQGIIFMMSSSPQPANLdylnAYTDEFTPIFKSFpeYYSSFQIN-----------GFNGVQSG 605
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 629 RLEVLvsLKDYNDwKEKiTKQELLIRMRNDLEaGLPGARV-SFSQPIMDNLSEAIMGTIadlaVFVSGNDLKIMRQIASE 707
Cdd:PRK09579 606 IGGFL--LKPWNE-RER-TQMELLPLVQAKLE-EIPGLQIfGFNLPSLPGTGEGLPFQF----VINTANDYESLLQVAQR 676
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 708 VLEIVKDMKGASEFGIEQEADSPQLTVRIDREAAARYGINVNDVQQMVEAAIGMQRIDTL-YEGPSdvppktparFGIVV 786
Cdd:PRK09579 677 VKQRAQESGKFAFLDIDLAFDKPEVVVDIDRAKAAQMGVSMQDLGGTLATLLGEGEINRFtIDGRS---------YKVIA 747
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 787 RFSKDYRSSKRAIENIPIISPKGERIPLSELAKISLEDGPTMIfRQEGRRTVTVRTNIRGRDQGGFVAELRQRVQKKIkl 866
Cdd:PRK09579 748 QVERPYRDNPGWLNNYYVKNEQGQLLPLSTLITLSDRARPRQL-NQFQQLNSAIISGFPIVSMGEAIETVQQIAREEA-- 824
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 867 PEGYEIRYGGQYENLARVGTRLAIVIPLTVGIIFGVLYLLYKNLKYVYVALACIPLSLVGGIYALLLRGYYFNVSGGVGF 946
Cdd:PRK09579 825 PEGFAFDYAGASRQYVQEGSALWVTFGLALAIIFLVLAAQFESFRDPLVILVTVPLSICGALIPLFLGVSSMNIYTQVGL 904
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 947 ISLFGIATMAGVLFVSRTNHLLHEDDeISVREAVKKAAVIQLRPMLMTILLALLGLIPATLASGVGSDVQRPLATVIVGG 1026
Cdd:PRK09579 905 VTLIGLISKHGILIVEFANQLRHEQG-LSRREAIEEAAAIRLRPVLMTTAAMVFGMVPLILATGAGAVSRFDIGLVIATG 983
|
1050
....*....|....*....
gi 446543436 1027 LFSALFLVLTVLPSLYLIL 1045
Cdd:PRK09579 984 MSIGTLFTLFVLPCIYTLL 1002
|
|
| PRK10555 |
PRK10555 |
multidrug efflux RND transporter permease AcrD; |
19-1049 |
1.28e-51 |
|
multidrug efflux RND transporter permease AcrD;
Pssm-ID: 182544 [Multi-domain] Cd Length: 1037 Bit Score: 198.13 E-value: 1.28e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 19 ASVGAIVF---GIWAWIDIRKEAYSDIADTQVRLIAKFPGKAAVEVEERVTIPIERVLNAIPKVAVRRSRTIN-GLVVFQ 94
Cdd:PRK10555 12 AWVLAILLcltGTLAIFSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSSGtGQASVT 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 95 FVFEDGTDDYFARTRLLERVRDA--DIPSEVEpTLGPMSSPVGEIYRYVVESKANHTPMELRTIQDW---NIMPKMLSIP 169
Cdd:PRK10555 92 LSFKAGTDPDEAVQQVQNQLQSAmrKLPQAVQ-NQGVTVRKTGDTNILTIAFVSTDGSMDKQDIADYvasNIQDPLSRVN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 170 GIADVVTFGglpKQF--HVVTTPDRLIRYKLTIEDVINAIQKNNLNTG-GNLllQGEQGFPIRSLGA-------IRTPEH 239
Cdd:PRK10555 171 GVGDIDAYG---SQYsmRIWLDPAKLNSFQMTTKDVTDAIESQNAQIAvGQL--GGTPSVDKQALNAtinaqslLQTPEQ 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 240 IENIVVKT-ENGVPVFIRDLGSVEIshpipsGVLGYTIQNDQEGlidvdSSVQGLvAIRRWGDPNIM--GERIRAKVKEI 316
Cdd:PRK10555 246 FRDITLRVnQDGSEVTLGDVATVEL------GAEKYDYLSRFNG-----KPASGL-GVKLASGANEMatAKLVLNRLDEL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 317 NdNYLPDGVQIRNTYDRTDLVNYTLRTIGKTLVEGVVVVSLVLIFFIGSIKASMVVVATIPFAMLFAFLLMNITGIPASL 396
Cdd:PRK10555 314 A-QYFPHGLEYKVAYETTSFVKASIEDVVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGYSINT 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 397 LSLGAI--DFGIIVDGAVVMVENVMRRYRDA--SPTDKkkgivrfTVDAASEVGTEIIFSILIIILAYLPIFSFERIEGR 472
Cdd:PRK10555 393 LTMFAMvlAIGLLVDDAIVVVENVERIMSEEglTPREA-------TRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGA 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 473 LFKPMAFTISFAILGALIFSMTAIPVLMSYIYRNYFESQNPGP---IEWHNPFYDWVERKYERLIEYLVERSKRVVVICF 549
Cdd:PRK10555 466 IYRQFSITIVSAMVLSVLVAMILTPALCATLLKPLKKGEHHGQkgfFGWFNRMFNRNAERYEKGVAKILHRSLRWILIYV 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 550 SIVGTLLVAgGLSLGTEFLPEMDEGGFNLRIFFPVGISLPESRKFIPKIREMIYRNEQVNV--VLSQLGRNDDGTDplpP 627
Cdd:PRK10555 546 LLLGGMVFL-FLRLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVEKVEKYYFTHEKDNVmsVFATVGSGPGGNG---Q 621
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 628 NRLEVLVSLKDYNDWKEKITKQELLIRMRNDLEAGLPGARVSFSQPimdnlsEAIMGTIADlavfvSGNDLKI------- 700
Cdd:PRK10555 622 NVARMFIRLKDWDERDSKTGTSFAIIERATKAFNKIKEARVIASSP------PAISGLGSS-----AGFDMELqdhagag 690
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 701 ---MRQIASEVLEIVKDMKGASEFGIEQEADSPQLTVRIDREAAARYGINVNDVQQMVEAAIGMQRI-DTLYEGpsdvpp 776
Cdd:PRK10555 691 hdaLMAARNQLLALAAKNPELTRVRHNGLDDSPQLQIDIDQRKAQALGVSIDDINDTLQTAWGSSYVnDFMDRG------ 764
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 777 ktpaRFGIV-VRFSKDYRSSKRAIENIPIISPKGERIPLSELAKISLEDGPTMIFRQEGRRTV-TVRTNIRGRDQGGFVA 854
Cdd:PRK10555 765 ----RVKKVyVQAAAPYRMLPDDINLWYVRNKDGGMVPFSAFATSRWETGSPRLERYNGYSAVeIVGEAAPGVSTGTAMD 840
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 855 ELRQRVQkkiKLPEGYEIRYGGQYENLARVGTRLAIVIPLTVGIIFGVLYLLYKNLKYVYVALACIPLSLVGGIYALLLR 934
Cdd:PRK10555 841 IMESLVK---QLPNGFGLEWTAMSYQERLSGAQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMR 917
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 935 GYYFNVSGGVGFISLFGIATMAGVLFVSRTNHLLHEDDEISvrEAVKKAAVIQLRPMLMTILLALLGLIPATLASGVGSD 1014
Cdd:PRK10555 918 GLENDVYFQVGLLTVIGLSAKNAILIVEFANEMNQKGHDLF--EATLHASRQRLRPILMTSLAFIFGVLPMATSTGAGSG 995
|
1050 1060 1070
....*....|....*....|....*....|....*
gi 446543436 1015 VQRPLATVIVGGLFSALFLVLTVLPsLYLILVGER 1049
Cdd:PRK10555 996 SQHAVGTGVMGGMISATILAIFFVP-LFFVLVRRR 1029
|
|
| PRK15127 |
PRK15127 |
multidrug efflux RND transporter permease subunit AcrB; |
19-1059 |
7.52e-48 |
|
multidrug efflux RND transporter permease subunit AcrB;
Pssm-ID: 185081 [Multi-domain] Cd Length: 1049 Bit Score: 186.26 E-value: 7.52e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 19 ASVGAIVFGIWAWIDIRK---EAYSDIADTQVRLIAKFPGKAAVEVEERVTIPIERVLNAIPKVAVRRSRT-INGLVVFQ 94
Cdd:PRK15127 12 AWVIAIIIMLAGGLAILKlpvAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSdSTGTVQIT 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 95 FVFEDGTDDYFARTRLLERVRDAD--IPSEVEPTlGPMSSPVGEIYRYVVESKANHTPMELRTIQDW---NIMPKMLSIP 169
Cdd:PRK15127 92 LTFESGTDADIAQVQVQNKLQLAMplLPQEVQQQ-GVSVEKSSSSFLMVVGVINTDGTMTQEDISDYvaaNMKDPISRTS 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 170 GIADVVTFGGlPKQFHVVTTPDRLIRYKLTIEDVINAIQKNNLNT-----GGNLLLQGEQ-GFPIRSLGAIRTPEHIENI 243
Cdd:PRK15127 171 GVGDVQLFGS-QYAMRIWMNPNELNKFQLTPVDVINAIKAQNAQVaagqlGGTPPVKGQQlNASIIAQTRLTSTEEFGKI 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 244 VVKT-ENGVPVFIRDLGSVEIshpipsGVLGYTIQNDQEGlidvdSSVQGLvAIRRWGDPNIM--GERIRAKVKEInDNY 320
Cdd:PRK15127 250 LLKVnQDGSRVRLRDVAKIEL------GGENYDIIAEFNG-----QPASGL-GIKLATGANALdtAAAIRAELAKM-EPF 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 321 LPDGVQIRNTYDRTDLVNYTLRTIGKTLVEGVVVVSLVLIFFIGSIKASMVVVATIPFAMLFAFLLMNITGIPASLLSL- 399
Cdd:PRK15127 317 FPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMf 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 400 -GAIDFGIIVDGAVVMVENVMRRYRDASPTDKKKgivrfTVDAASEVGTEIIFSILIIILAYLPIFSFERIEGRLFKPMA 478
Cdd:PRK15127 397 gMVLAIGLLVDDAIVVVENVERVMAEEGLPPKEA-----TRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFS 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 479 FTI----SFAILGALIFSMTAIPVLMSYIYRNYFESQNPGPIEWHNPFYDWVERKYERLIEYLVERSKRVVVICFSIVGT 554
Cdd:PRK15127 472 ITIvsamALSVLVALILTPALCATMLKPIAKGDHGEGKKGFFGWFNRMFEKSTHHYTDSVGNILRSTGRYLVLYLIIVVG 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 555 LLVAGgLSLGTEFLPEMDEGGFNLRIFFPVGISLPESRKFIPKIREMIYRNEQVNVVlSQLGRNDDGTDPLPPNRLEVLV 634
Cdd:PRK15127 552 MAYLF-VRLPSSFLPDEDQGVFLTMVQLPAGATQERTQKVLNEVTDYYLTKEKNNVE-SVFAVNGFGFAGRGQNTGIAFV 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 635 SLKDyndWKEKITKQellirmrNDLEAGLPGARVSFSQpIMDNLSEAI-MGTIADLAVfVSGNDLKIMRQ--IASEVLEI 711
Cdd:PRK15127 630 SLKD---WADRPGEE-------NKVEAITMRATRAFSQ-IKDAMVFAFnLPAIVELGT-ATGFDFELIDQagLGHEKLTQ 697
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 712 VKD------------MKGASEFGIEqeaDSPQLTVRIDREAAARYGINVNDVQQMVEAAIGMQRIDTLYEgpsdvppktP 779
Cdd:PRK15127 698 ARNqllgeaakhpdmLVGVRPNGLE---DTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFID---------R 765
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 780 ARFGIV-VRFSKDYRSSKRAIENIPIISPKGERIPLSELAKISLEDGPTMIFRQEGRRTVTVRTNIRGRDQGGFVAELRQ 858
Cdd:PRK15127 766 GRVKKVyVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELME 845
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 859 RVQKKIKLPEGYEIRYGGQYENLArvGTRLAIVIPLTVGIIFGVLYLLYKNLKYVYVALACIPLSLVGGIYALLLRGYYF 938
Cdd:PRK15127 846 ELASKLPTGVGYDWTGMSYQERLS--GNQAPALYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTN 923
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 939 NVSGGVGFISLFGIATMAGVLFVSRTNHLLHEDDEiSVREAVKKAAVIQLRPMLMTILLALLGLIPATLASGVGSDVQRP 1018
Cdd:PRK15127 924 DVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGK-GLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNA 1002
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|.
gi 446543436 1019 LATVIVGGLFSALFLVLTVLPSLYLILvgERDYVPKKQNLE 1059
Cdd:PRK15127 1003 VGTGVMGGMVTATVLAIFFVPVFFVVV--RRRFSRKNEDIE 1041
|
|
| PRK10614 |
PRK10614 |
multidrug efflux system subunit MdtC; Provisional |
51-1043 |
1.18e-44 |
|
multidrug efflux system subunit MdtC; Provisional
Pssm-ID: 182589 [Multi-domain] Cd Length: 1025 Bit Score: 176.07 E-value: 1.18e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 51 AKFPGKAAVEVEERVTIPIERVLNAIPKVAVRRSRTING--LVVFQFVFEDGTDDyfartrlleRVRDADIPSEVEPTLG 128
Cdd:PRK10614 49 ASLPGASPETMASSVATPLERSLGRIAGVNEMTSSSSLGstRIILQFDFDRDING---------AARDVQAAINAAQSLL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 129 PMSSPVGEIYRYVVESKA----------NHTPMELRTIQDWNIMPKMLSIPGIADVVTFGGLPKQFHVVTTPDRLIRYKL 198
Cdd:PRK10614 120 PSGMPSRPTYRKANPSDApimiltltsdTYSQGQLYDFASTQLAQTISQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGV 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 199 TIEDVINAIQKNNLNTGGNLLLQGEQGFPIRSLGAIRTPEHIENIVVKTENGVPVFIRDLGSVEIShpipsgvlgytIQN 278
Cdd:PRK10614 200 SLDDVRQAISNANVRRPQGAVEDGTHRWQIQTNDELKTAAEYQPLIIHYNNGAAVRLGDVATVTDS-----------VQD 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 279 DQE-GLIDVDSSVqgLVAIRRWGDPNIMG--ERIRAKVKEINDNyLPDGVQIRNTYDRTDLVNYTLRTIGKTLVEGVVVV 355
Cdd:PRK10614 269 VRNaGMTNAKPAI--LLMIRKLPEANIIQtvDRIRAKLPELRET-IPAAIDLQIAQDRSPTIRASLEEVEQTLAISVALV 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 356 SLVLIFFIGSIKASMVVVATIPFAMLFAFLLMNITGIPASLLSLGA--IDFGIIVDGAVVMVENVMRRYRDA-SPTDKKK 432
Cdd:PRK10614 346 ILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMAltIATGFVVDDAIVVLENISRHLEAGmKPLQAAL 425
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 433 GIVRftvdaasEVGTEIIFSILIIILAYLPIFSFERIEGRLFKPMAFTISFAILGALIFSMTAIPVLMSYIYRNYFESQN 512
Cdd:PRK10614 426 QGVR-------EVGFTVLSMSLSLVAVFLPLLLMGGLPGRLFREFAVTLSVAIGISLLVSLTLTPMMCAWLLKSSKPREQ 498
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 513 PgPIEWHNPFYDWVERKYERLIEYLVERSKRVVVICFSIVGtLLVAGGLSLGTEFLPEMDEG---GFnlrIFFPVGISLP 589
Cdd:PRK10614 499 K-RLRGFGRMLVALQQGYGRSLKWVLNHTRWVGVVLLGTIA-LNVWLYISIPKTFFPEQDTGrlmGF---IQADQSISFQ 573
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 590 ESRKFIPKIREMIYRNEQVNVVLSQLGRNDdgtdplpPNRLEVLVSLKDYNDWKEkiTKQELLIRMRNDLeAGLPGARVs 669
Cdd:PRK10614 574 AMRGKLQDFMKIIRDDPAVDNVTGFTGGSR-------VNSGMMFITLKPLSERSE--TAQQVIDRLRVKL-AKEPGANL- 642
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 670 FSQPIMDnLSEAIMGTIADLAVFVSGNDLKIMRQIASEVLEIVKDMKGASEFGIEQEADSPQLTVRIDREAAARYGINVN 749
Cdd:PRK10614 643 FLMAVQD-IRVGGRQSNASYQYTLLSDDLAALREWEPKIRKALAALPELADVNSDQQDKGAEMALTYDRDTMARLGIDVQ 721
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 750 DVQQMVEAAIGMQRIDTLYEgPSDvppktpaRFGIVVRFSKDYRSSKRAIENIPIISPKGERIPLSELAKISLEDGPTMI 829
Cdd:PRK10614 722 AANSLLNNAFGQRQISTIYQ-PLN-------QYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSV 793
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 830 FRQEGRRTVTVRTNIrgrDQGGFVAELR---QRVQKKIKLPEGYEIRYGGQYENLARVGTRLAIVIPLTVGIIFGVLYLL 906
Cdd:PRK10614 794 NHQGLSAASTISFNL---PTGKSLSDASaaiERAMTQLGVPSTVRGSFAGTAQVFQETMNSQLILILAAIATVYIVLGIL 870
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 907 YKNLKYVYVALACIPLSLVGGIYALLLRGYYFNVSGGVGFISLFGIATMAGVLFV------SRTNHLlheddeiSVREAV 980
Cdd:PRK10614 871 YESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVdfaleaQRNGNL-------TAQEAI 943
|
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446543436 981 KKAAVIQLRPMLMTILLALLGLIPATLASGVGSDVQRPLATVIVGGLFSALFLVLTVLPSLYL 1043
Cdd:PRK10614 944 FQACLLRFRPIMMTTLAALFGALPLVLSGGDGAELRQPLGITIVGGLVMSQLLTLYTTPVVYL 1006
|
|
| PRK10503 |
PRK10503 |
MdtB/MuxB family multidrug efflux RND transporter permease subunit; |
149-1044 |
5.06e-38 |
|
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
Pssm-ID: 182501 [Multi-domain] Cd Length: 1040 Bit Score: 154.89 E-value: 5.06e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 149 TPMELRTIQDW---NIMPKMLSIPGIADVVTFGGLPKQFHVVTTPDRLIRYKLTIEDVINAIQKNNLNTGgnlllQGEQG 225
Cdd:PRK10503 156 TAMPMTQVEDMvetRVAQKISQVSGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSA-----KGSLD 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 226 FPIRS--LGA---IRTPEHIENIVVKTENGVPVFIRDLGSVEisHPIPSGVLGYTIQNDQEGLIDVdssvqglvaiRRWG 300
Cdd:PRK10503 231 GPTRAvtLSAndqMQSAEEYRQLIIAYQNGAPIRLGDVATVE--QGAENSWLGAWANKQQAIVMNV----------QRQP 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 301 DPNIM--GERIRAKVKEINDNyLPDGVQIRNTYDRTDLVNYTLRTIGKTLVEGVVVVSLVLIFFIGSIKASMVVVATIPF 378
Cdd:PRK10503 299 GANIIatADSIRQMLPQLTES-LPKSVKVTVLSDRTTNIRASVDDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPL 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 379 AMLFAFLLMNITGIPASLLSLGA--IDFGIIVDGAVVMVENVMRRyrdaspTDKKKGIVRFTVDAASEVGTEIIFSILII 456
Cdd:PRK10503 378 SLIGTFAVMVFLDFSINNLTLMAltIATGFVVDDAIVVIENISRY------IEKGEKPLAAALKGAGEIGFTIISLTFSL 451
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 457 ILAYLPIFSFERIEGRLFKPMAFTISFAILGALIFSMTAIPVLMSYIYrnyfesqNPGPIEWHNPFYDWVERKYERLIEY 536
Cdd:PRK10503 452 IAVLIPLLFMGDIVGRLFREFAVTLAVAILISAVVSLTLTPMMCARML-------SQESLRKQNRFSRASERMFDRVIAA 524
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 537 LVERSKRVV---VICFSI-VGTLLVAGGLSLGTE--FLPEMDEGGFNLRIFFPVGISLPESRKFIPKIREMIYRNEQVNV 610
Cdd:PRK10503 525 YGRGLAKVLnhpWLTLSVaLSTLLLTVLLWIFIPkgFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQS 604
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 611 VLSQLGRndDGTDP-LPPNRLEVlvSLKDYNDWKEKItkQELLIRMRNDLeAGLPGARVsFSQPIMDnLSEAIMGTIADL 689
Cdd:PRK10503 605 LTSFVGV--DGTNPsLNSARLQI--NLKPLDERDDRV--QKVIARLQTAV-AKVPGVDL-YLQPTQD-LTIDTQVSRTQY 675
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 690 AVFVSGNDLKIMRQIASEVLEIVKDMKGASEFGIEQEADSPQLTVRIDREAAARYGINVNDVQQMVEAAIGMQRIDTLYe 769
Cdd:PRK10503 676 QFTLQATSLDALSTWVPKLMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIY- 754
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 770 gpsdvppkTPA-RFGIVVRFSKDYRSSKRAIENIPIISPKGERIPLSELAKISLEDGPTMIFRQEGRRTVTVRTNIRGRD 848
Cdd:PRK10503 755 --------TQAnQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIATIEQRFGPLSINHLDQFPSTTISFNVPDGY 826
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 849 QGGFVAELRQRVQKKIKLPEGYEIRYGGQYENL-ARVGTRLAIVIPLTVGIiFGVLYLLYKNLKYVYVALACIPLSLVGG 927
Cdd:PRK10503 827 SLGDAVQAIMDTEKTLNLPADITTQFQGSTLAFqSALGSTVWLIVAAVVAM-YIVLGVLYESFIHPITILSTLPTAGVGA 905
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 928 IYALLLRGYYFNVSGGVGFISLFGIATMAGVLFVSRTnhLLHEDDE-ISVREAVKKAAVIQLRPMLMTILLALLGLIPAT 1006
Cdd:PRK10503 906 LLALMIAGSELDVIAIIGIILLIGIVKKNAIMMIDFA--LAAEREQgMSPRDAIYQACLLRFRPILMTTLAALLGALPLM 983
|
890 900 910
....*....|....*....|....*....|....*...
gi 446543436 1007 LASGVGSDVQRPLATVIVGGLFSALFLVLTVLPSLYLI 1044
Cdd:PRK10503 984 LSTGVGAELRRPLGICMVGGLIVSQVLTLFTTPVIYLL 1021
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
3-423 |
1.13e-14 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 78.99 E-value: 1.13e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 3 RNLLEGMMRFRVATLAASVGAIVFGIWAWIDIRKEAYSDIADTQVRLIAKFPGKAAVEVEERVTIPIERVLNAIPkvAVR 82
Cdd:COG0841 516 GRLLRWALRHRKLTLLVALALLALSVLLFGRLPTEFFPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVP--EVE 593
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 83 RSRTINGLVVFQ------FVF---------EDGTDDYFARTR-LLERVRDADIPSEVEPTLGPmssPVGEIYRYVVESKa 146
Cdd:COG0841 594 SVFSVVGFSGGGsgsnsgTIFvtlkpwderDRSADEIIARLReKLAKIPGARVFVFQPPAGGL---GSGAPIEVQLQGD- 669
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 147 nhtpmELRTIQDW--NIMPKMLSIPGIADVVTFGGLPK-QFHVVTTPDRLIRYKLTIEDVINAIQK-------NNLNTGG 216
Cdd:COG0841 670 -----DLEELAAAaeKLLAALRQIPGLVDVRSDLQLGKpELQLDIDREKAAALGVTVADVASTLRAalggryvNDFNRGG 744
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 217 N---LLLQGEQGFpirslgaIRTPEHIENIVVKTENGVPVFIRDLGSVEISHpipsgvlGYTIQNDQEGLIDVdsSVQGL 293
Cdd:COG0841 745 ReydVRVQAPEED-------RNSPEDLENLYVRTPDGEMVPLSSVATIEEGT-------GPSSINRYNGQRSV--TVSAN 808
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 294 VAirrwgdPNI-MGERIRAKVKEINDNYLPDGVQIR---NTYDRTDLVNYTLRTIGktlvegvvvvslVLIFFI------ 363
Cdd:COG0841 809 LA------PGVsLGEALAAIEELAAELKLPPGVSIEftgQAEEEQESFSSLGLAFL------------LALLLVylvlaa 870
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446543436 364 --GSIKASMVVVATIPFAMLFAFLLMNITGIPASLLSL-GAID-FGIIVDGAVVMVENVMRRYR 423
Cdd:COG0841 871 qfESFIQPLIILLTVPLALIGALLGLLLTGTPLNIYSQiGLIMlIGIVVKNAILLVDFANQLRE 934
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
852-1059 |
2.13e-11 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 68.35 E-value: 2.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 852 FVAELRQRVQKKIKlpEGYEIRYGG----QYENLARVGTRLAIVIPLTVGIIFGVLYLLYKNLKYVYVALACIPLSLVG- 926
Cdd:COG1033 182 VVAEIRAIIAKYED--PGVEVYLTGfpvlRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWt 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 927 -GIYALLlrGYYFN-VSGGVGFIsLFGIATMAGVLFVSRTNHLLHEDDeiSVREAVKKAAVIQLRPMLMTILLALLGLip 1004
Cdd:COG1033 260 lGLMGLL--GIPLSpLTILVPPL-LLAIGIDYGIHLLNRYREERRKGL--DKREALREALRKLGPPVLLTSLTTAIGF-- 332
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 446543436 1005 ATLASgvgSDVQ--RPLATVIVGGLFSALFLVLTVLPSLYLILVGERDYVPKKQNLE 1059
Cdd:COG1033 333 LSLLF---SDIPpiRDFGIVAAIGVLLAFLTSLTLLPALLSLLPRPKPKTRRLKKPP 386
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
806-1045 |
5.62e-08 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 57.18 E-value: 5.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 806 SPKGERIP----LSELAKISLEDGPTMIFRQ----EGRRT-VTVRT-NIRGRDQGGFVAELRQRVQKKIKlPEGYEIRYG 875
Cdd:COG1033 512 DPKYYALPesreLLAQLLLLLSSPPGDDLSRfvdeDYSAArVTVRLkDLDSEEIKALVEEVRAFLAENFP-PDGVEVTLT 590
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 876 GQ----YENLARVGTRLAIVIPLTVGIIFGVLYLLYKNLKYVYVALACI--PLSLVGGIYALLlrGYYFNVSGGVGFISL 949
Cdd:COG1033 591 GSavlfAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNllPILLTFGLMGLL--GIPLNIATAVVASIA 668
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 950 FGIATMAGVLFVSRTNHLLHEDDeiSVREAVKKAAVIQLRPMLMTILLALLGLIPATLASGVGsdvQRPLATVIVGGLFS 1029
Cdd:COG1033 669 LGIGVDYTIHFLSRYREERRKGG--DLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPP---LADFGLLLALGLLV 743
|
250
....*....|....*.
gi 446543436 1030 ALFLVLTVLPSLYLIL 1045
Cdd:COG1033 744 ALLAALLLLPALLLLL 759
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
824-1049 |
3.03e-06 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 51.30 E-value: 3.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 824 DGPTMIFRQEGRRTVTVRTNIRGrDQGGFVAELRQRVQKKIK--LPEGYEIRYGGQ-------YENLARVGTRLAIVipl 894
Cdd:COG2409 102 DDPAAGLVSEDGKAALVTVTLDG-DAGDEAAEAVDALRDAVAaaPAPGLTVYVTGPaalaadlNEAFEEDLGRAELI--- 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 895 TVGIIFGVLYLLYKNLkyvyvALACIPL-----SLVGGIYALLLRGYYFNVSG-GVGFISLFGIAtmAGV----LFVSRT 964
Cdd:COG2409 178 TLPVALVVLLLVFRSL-----VAALLPLltaglAVGVALGLLALLAAFTDVSSfAPNLLTMLGLG--VGIdyalFLVSRY 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 965 NHLL--HEDDEISVREAVKKAAviqlRPML---MTILLALLGLipatLASGVGSdvQRPLATVIVGGLFSALFLVLTVLP 1039
Cdd:COG2409 251 REELraGEDREEAVARAVATAG----RAVLfsgLTVAIALLGL----LLAGLPF--LRSMGPAAAIGVAVAVLAALTLLP 320
|
250
....*....|
gi 446543436 1040 SLyLILVGER 1049
Cdd:COG2409 321 AL-LALLGRR 329
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
727-1049 |
2.25e-05 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 48.83 E-value: 2.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 727 ADSPQLTVRIDREAAARYGINVNDVQQMVEAA---IGMQRIDTLYEGPSdvpPKTPARFgivvrfskdyrSSKRAIENIP 803
Cdd:pfam00873 179 GSEYAMRIWLDPQKLARYGLTLTDVVSALKEQnvnIGAGQLEGQGLQAL---IRAQGQL-----------QSAEDFEKII 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 804 IISPKGERIPLSELAKI-----------SLEDGPT---MIFRQEGRRTVTVRTNIRGRdqggfVAELRQrvqkkiKLPEG 869
Cdd:pfam00873 245 VKNQDGSPVRLRDVATVelgselyrgfaTFNGKPAvglGVQKLPGANAIETADAVRAK-----LAELKP------TFPQG 313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 870 YEIRYGGQYENLARVGTRlAIVIPLTVGII--FGVLYLLYKNLKYVYVALACIPLSLVGGIYALLLRGYYFNVsggvgfI 947
Cdd:pfam00873 314 VEIVVVYDTTPFIRASIE-EVVKTLLEAIVlvILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINT------L 386
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 948 SLFGIATMAGVLFvsrtnhllheDDEISV---------------REAVKKAAVIQLRPMLMTILLALLGLIPATLASGVG 1012
Cdd:pfam00873 387 TLGGLVLAIGLVV----------DDAIVVveniervleenglkpLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLT 456
|
330 340 350
....*....|....*....|....*....|....*..
gi 446543436 1013 SDVQRPLATVIVGGLFSALFLVLTVLPSLYLILVGER 1049
Cdd:pfam00873 457 GRIFRQFAITIVLAILLSVLVALTLTPALCATLLKPR 493
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
888-1056 |
6.75e-05 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 46.52 E-value: 6.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 888 LAIVIPLTVGIIFGVLYLLYKNLKYVYVALACIPLSLVG--GIYALLLRGYYFNVSG---GVGFISLFGIATMAGVLFVS 962
Cdd:pfam03176 144 LGLIEAVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAaqGLVAILAHILGIGLSTfalNLLVVLLIAVGTDYALFLVS 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 963 RtnhlLHE--DDEISVREAVKKAaviqLRPMLMTILLAllGLIPA-TLASGVGSD--VQRPLATVIVGGLFSALFLVLTV 1037
Cdd:pfam03176 224 R----YREelRAGEDREEAVIRA----VRGTGKVVTAA--GLTVAiAMLALSFARlpVFAQVGPTIAIGVLVDVLAALTL 293
|
170
....*....|....*....
gi 446543436 1038 LPSLyLILVGERDYVPKKQ 1056
Cdd:pfam03176 294 LPAL-LALLGRWGLWPPKR 311
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
878-1069 |
3.61e-03 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 41.52 E-value: 3.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 878 YENLARVGTRLAIVIPLTVGIIFGVLYLLYKNLKYVYVALACIPLSLVGGI-YALLLRGYYFNVSggVGFISLF-GIATM 955
Cdd:TIGR03480 261 DEELATVSEGATVAGLLSFVLVLVLLWLALRSPRLVFAVLVTLIVGLILTAaFATLAVGHLNLIS--VAFAVLFiGLGVD 338
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 956 AGVLFVSRTNHLLHEDDEIsvREAVKKAAVIQLRPMLM---TILLALLGLIPaTLASGVGSdvqrpLATVIVGGLFSALF 1032
Cdd:TIGR03480 339 FAIQFSLRYREERFRGGNH--REALSVAARRMGAALLLaalATAAGFFAFLP-TDYKGVSE-----LGIIAGTGMFIALF 410
|
170 180 190
....*....|....*....|....*....|....*....
gi 446543436 1033 LVLTVLPSLYLIL--VGERDYVPKKqNLEPysyLDQYPL 1069
Cdd:TIGR03480 411 VTLTVLPALLRLLrpPRRRKPPGYA-TLAP---LDAFLR 445
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
789-1059 |
6.75e-03 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 40.59 E-value: 6.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 789 SKDYRSSKRAIENIPIISPKGERIPLSELA-KISLEDGPTMiFRQE--GRRTVT-VRTNIRGRDQGGFVAELRQRVQKKI 864
Cdd:TIGR00921 86 EKPYVTNVRSAADIMRQIPGNFPLPVTMPEvRPLMSEYPRS-KEMFlsKDHTVAiIIVQLKSDADYKQVVPIYNDVERSL 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 865 ---KLPEGYE--------IRYGGQYENLARVGTRLAIVIPLTVGiifgVLYLLYKNLKYVYVALACIPLSLVGGIYALLL 933
Cdd:TIGR00921 165 ertNPPSGKFldvtgspaINYDIEREFGKDMGTTMAISGILVVL----VLLLDFKRWWRPLLPLVIILFGVAWVLGIMGW 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446543436 934 RGYYFNVSGGVGFISLFGIATMAGVLFVSRTNHLLHE--DDEISVREAVKKAAviqlRPMLMTILLALLGLIpATLASGV 1011
Cdd:TIGR00921 241 LGIPLYATTLLAVPMLIGVGIDYGIQTLNRYEEERDIgrAKGEAIVTAVRRTG----RAVLIALLTTSAGFA-ALALSEF 315
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 446543436 1012 GSdVQRpLATVIVGGLFSALFLVLTVLPSLyLILVGE-RDYVPKKQNLE 1059
Cdd:TIGR00921 316 PM-VSE-FGLGLVAGLITAYLLTLLVLPAL-LQSIDIgREKVKKEIIAI 361
|
|
| |
