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Conserved domains on  [gi|446539539|ref|WP_000616885|]
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MULTISPECIES: phosphomevalonate kinase [Staphylococcus]

Protein Classification

Pmev_kin_Gr_pos family protein( domain architecture ID 11492108)

Pmev_kin_Gr_pos family protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Pmev_kin_Gr_pos TIGR01220
phosphomevalonate kinase, ERG8-type, Gram-positive branch; This enzyme is part of the ...
2-358 0e+00

phosphomevalonate kinase, ERG8-type, Gram-positive branch; This enzyme is part of the mevalonate pathway, one of two alternative pathways for the biosynthesis of IPP. In an example of nonorthologous gene displacement, two different types of phosphomevalonate kinase are found - the animal type and this ERG8 type. This model represents the low GC Gram-positive organism forms of the ERG8 type of phosphomevalonate kinase. [Central intermediary metabolism, Other]


:

Pssm-ID: 130287 [Multi-domain]  Cd Length: 358  Bit Score: 578.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539    2 IQVKAPGKLYIAGEYAVTEPGYKSVLIALDRFVTATIEEADQYKGTIHSKALHHNPVTFSRDEDSIVISDPHAAKQLNYV 81
Cdd:TIGR01220   1 IVVHAPGKLFVAGEYAVVEPGNPAILVAVDRFVTVTVEDADGAADVIISSDLGPQPVGWRRHDGRLVVRDPDARSALAYV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539   82 VTAIEIFEQYAKSCDIAMKHFHLTIDSNLDDSNGHKYGLGSSAAVLVSVIKVLNEFYDMKLSNLYIYKLAVIANMKLQSL 161
Cdd:TIGR01220  81 VSAIETVERYAGERNQKLPALHLSVSSRLDEADGRKYGLGSSGAVTVATVKALNAFYDLELSNDEIFKLAMLATAELQPK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539  162 SSCGDIAVSVYSGWLAYSTFDHEWVKHQIEDTTVEEVLIKNWPGLHIEPLQAPENMEVLIGWTGSPASSPHFVSEVKRLK 241
Cdd:TIGR01220 161 GSCGDIAASTYGGWIAYSTFDHDWVLQLARRVGVDRTLKAPWPGLSIRPLPAPKGLTLLIGWTGSPASTASLVSDVHRRK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539  242 SDP-SFYGDFLEDSHRCVEKLIHAFKTNNIKGVQKMVRQNRTIIQRMDKEATVDIETEKLKYLCDIAEKYHGASKTSGAG 320
Cdd:TIGR01220 241 WRGsASYQRFLETSTDCVESAITAFETGDITSLQKEIRRNRQELARLDDEVGVGIETEKLKALCDAAEAYGGAAKPSGAG 320
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 446539539  321 GGDCGITIINKDVDKEKIYDEWTKHGIKPLKFNIYHGQ 358
Cdd:TIGR01220 321 GGDCGIAILDAEADITHVRQRWETAGILPLPLTPYLEG 358
 
Name Accession Description Interval E-value
Pmev_kin_Gr_pos TIGR01220
phosphomevalonate kinase, ERG8-type, Gram-positive branch; This enzyme is part of the ...
2-358 0e+00

phosphomevalonate kinase, ERG8-type, Gram-positive branch; This enzyme is part of the mevalonate pathway, one of two alternative pathways for the biosynthesis of IPP. In an example of nonorthologous gene displacement, two different types of phosphomevalonate kinase are found - the animal type and this ERG8 type. This model represents the low GC Gram-positive organism forms of the ERG8 type of phosphomevalonate kinase. [Central intermediary metabolism, Other]


Pssm-ID: 130287 [Multi-domain]  Cd Length: 358  Bit Score: 578.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539    2 IQVKAPGKLYIAGEYAVTEPGYKSVLIALDRFVTATIEEADQYKGTIHSKALHHNPVTFSRDEDSIVISDPHAAKQLNYV 81
Cdd:TIGR01220   1 IVVHAPGKLFVAGEYAVVEPGNPAILVAVDRFVTVTVEDADGAADVIISSDLGPQPVGWRRHDGRLVVRDPDARSALAYV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539   82 VTAIEIFEQYAKSCDIAMKHFHLTIDSNLDDSNGHKYGLGSSAAVLVSVIKVLNEFYDMKLSNLYIYKLAVIANMKLQSL 161
Cdd:TIGR01220  81 VSAIETVERYAGERNQKLPALHLSVSSRLDEADGRKYGLGSSGAVTVATVKALNAFYDLELSNDEIFKLAMLATAELQPK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539  162 SSCGDIAVSVYSGWLAYSTFDHEWVKHQIEDTTVEEVLIKNWPGLHIEPLQAPENMEVLIGWTGSPASSPHFVSEVKRLK 241
Cdd:TIGR01220 161 GSCGDIAASTYGGWIAYSTFDHDWVLQLARRVGVDRTLKAPWPGLSIRPLPAPKGLTLLIGWTGSPASTASLVSDVHRRK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539  242 SDP-SFYGDFLEDSHRCVEKLIHAFKTNNIKGVQKMVRQNRTIIQRMDKEATVDIETEKLKYLCDIAEKYHGASKTSGAG 320
Cdd:TIGR01220 241 WRGsASYQRFLETSTDCVESAITAFETGDITSLQKEIRRNRQELARLDDEVGVGIETEKLKALCDAAEAYGGAAKPSGAG 320
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 446539539  321 GGDCGITIINKDVDKEKIYDEWTKHGIKPLKFNIYHGQ 358
Cdd:TIGR01220 321 GGDCGIAILDAEADITHVRQRWETAGILPLPLTPYLEG 358
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
6-326 1.56e-88

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 267.48  E-value: 1.56e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539   6 APGKLYIAGEYAVTEpGYKSVLIALDRFVTATIEEADQYKGTIHSKALHHnpvTFSRDEDsivisdphAAKQLNYVVTAI 85
Cdd:COG1577    1 APGKLILFGEHAVVY-GQPAIAVAVDRRATVTVEPSDDDKLRIESPDLGG---TLDLDPL--------ADAALRYIKAAI 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539  86 EIFEQYaksCDIAMKHFHLTIDSNLddsnGHKYGLGSSAAVLVSVIKVLNEFYDMKLSNLYIYKLAVIANMKLQSLSSCG 165
Cdd:COG1577   69 EAALEY---LGLPLKGFDIEIDSEI----PRKRGLGSSAAVAVAVIRALAAFYGVELSKEELFKLALEAEKIVHGNPSGL 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539 166 DIAVSVYSGWLAYSTFDHEwvkhqiedttveevliknwpglhiEPLQAPENMEVLIGWTGSPASSPHFVSEVKRLK-SDP 244
Cdd:COG1577  142 DTAASTYGGPIYYQRGDRA------------------------EPLELPKNLPLVVGDTGVPASTKELVAKVRKLKeRNP 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539 245 SFYGDFLEDSHRCVEKLIHAFKTNNIKGVQKMVRQNRTIIQRMdkeatvDIETEKLKYLCDIAEKYHG-ASKTSGAGGGD 323
Cdd:COG1577  198 ELYEAFLEEIGDLVEEAIEALEEGDLEALGELMNENHGLLRAL------GVSTPELDRLVEAARKAGAlGAKLTGAGGGG 271

                 ...
gi 446539539 324 CGI 326
Cdd:COG1577  272 CVI 274
PRK03926 PRK03926
mevalonate kinase; Provisional
1-324 6.68e-17

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 80.10  E-value: 6.68e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539   1 MIQVKAPGKLYIAGEYAVT--EPGYKSVlIALDRFVTAtieeadqykgtihskalhhnpvtfSRDEDSIVISDPH--AAK 76
Cdd:PRK03926   1 MVLCSAPGKIYLFGEHAVVygKPAIACA-IDLRTYVRA------------------------EFNDDSIYIESDYgkTGE 55
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539  77 QLNYVVTAIEIFEQYAkscdiAMKHFHLTIDSNLDDSNghkyGLGSSAAVLVSVIKVLNEFYDMKLSNLYIYKLAVIANM 156
Cdd:PRK03926  56 KHPYVSAAIEKMREEA-----DKDGVTVSITSQIPVGS----GLGSSAAVTVATIGALNRLLGLGLSLEEIAKLGHKVEL 126
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539 157 KLQSLSSCGDIAVSVYSGWLAYSTfdhewvkhqiedttveevliknwpGLHIEPLQAPenmeVLIGWTGSPASSPHFVSE 236
Cdd:PRK03926 127 LVQGAASPTDTYVSTMGGFVTIPD------------------------RKKLPFPECG----IVVGYTGSSGSTKELVAN 178
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539 237 VKRLKSD-PSFYGDFLEDSHRCVEKLIHAFKTNNIKGVQKMVRQNRTIIQrmdkeaTVDIETEKLKYLCdIAEKYHGA-- 313
Cdd:PRK03926 179 VRKLKEEyPELIEPILSSIGKISEKGEELILSGDYVSLGELMNINQGLLD------ALGVSTKELSELI-YAARTAGAlg 251
                        330
                 ....*....|.
gi 446539539 314 SKTSGAGGGDC 324
Cdd:PRK03926 252 AKITGAGGGGC 262
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
261-348 3.72e-11

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 58.64  E-value: 3.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539  261 LIHAFKTNNIKGVQKMVRQNRTIIQrmdKEATVDIETEKLKYLCDIAEKYHGASKTSGAGGGDCGITIINKDVDKEKIYD 340
Cdd:pfam08544   1 LLEALLRGDLEELGKLLTESAESLE---PLLVVGILPPELDELLEALLELGLGAKLSGSGGGPTVFALFKDEDDAEEVAR 77

                  ....*...
gi 446539539  341 EWTKHGIK 348
Cdd:pfam08544  78 ALREAGKK 85
 
Name Accession Description Interval E-value
Pmev_kin_Gr_pos TIGR01220
phosphomevalonate kinase, ERG8-type, Gram-positive branch; This enzyme is part of the ...
2-358 0e+00

phosphomevalonate kinase, ERG8-type, Gram-positive branch; This enzyme is part of the mevalonate pathway, one of two alternative pathways for the biosynthesis of IPP. In an example of nonorthologous gene displacement, two different types of phosphomevalonate kinase are found - the animal type and this ERG8 type. This model represents the low GC Gram-positive organism forms of the ERG8 type of phosphomevalonate kinase. [Central intermediary metabolism, Other]


Pssm-ID: 130287 [Multi-domain]  Cd Length: 358  Bit Score: 578.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539    2 IQVKAPGKLYIAGEYAVTEPGYKSVLIALDRFVTATIEEADQYKGTIHSKALHHNPVTFSRDEDSIVISDPHAAKQLNYV 81
Cdd:TIGR01220   1 IVVHAPGKLFVAGEYAVVEPGNPAILVAVDRFVTVTVEDADGAADVIISSDLGPQPVGWRRHDGRLVVRDPDARSALAYV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539   82 VTAIEIFEQYAKSCDIAMKHFHLTIDSNLDDSNGHKYGLGSSAAVLVSVIKVLNEFYDMKLSNLYIYKLAVIANMKLQSL 161
Cdd:TIGR01220  81 VSAIETVERYAGERNQKLPALHLSVSSRLDEADGRKYGLGSSGAVTVATVKALNAFYDLELSNDEIFKLAMLATAELQPK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539  162 SSCGDIAVSVYSGWLAYSTFDHEWVKHQIEDTTVEEVLIKNWPGLHIEPLQAPENMEVLIGWTGSPASSPHFVSEVKRLK 241
Cdd:TIGR01220 161 GSCGDIAASTYGGWIAYSTFDHDWVLQLARRVGVDRTLKAPWPGLSIRPLPAPKGLTLLIGWTGSPASTASLVSDVHRRK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539  242 SDP-SFYGDFLEDSHRCVEKLIHAFKTNNIKGVQKMVRQNRTIIQRMDKEATVDIETEKLKYLCDIAEKYHGASKTSGAG 320
Cdd:TIGR01220 241 WRGsASYQRFLETSTDCVESAITAFETGDITSLQKEIRRNRQELARLDDEVGVGIETEKLKALCDAAEAYGGAAKPSGAG 320
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 446539539  321 GGDCGITIINKDVDKEKIYDEWTKHGIKPLKFNIYHGQ 358
Cdd:TIGR01220 321 GGDCGIAILDAEADITHVRQRWETAGILPLPLTPYLEG 358
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
6-326 1.56e-88

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 267.48  E-value: 1.56e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539   6 APGKLYIAGEYAVTEpGYKSVLIALDRFVTATIEEADQYKGTIHSKALHHnpvTFSRDEDsivisdphAAKQLNYVVTAI 85
Cdd:COG1577    1 APGKLILFGEHAVVY-GQPAIAVAVDRRATVTVEPSDDDKLRIESPDLGG---TLDLDPL--------ADAALRYIKAAI 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539  86 EIFEQYaksCDIAMKHFHLTIDSNLddsnGHKYGLGSSAAVLVSVIKVLNEFYDMKLSNLYIYKLAVIANMKLQSLSSCG 165
Cdd:COG1577   69 EAALEY---LGLPLKGFDIEIDSEI----PRKRGLGSSAAVAVAVIRALAAFYGVELSKEELFKLALEAEKIVHGNPSGL 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539 166 DIAVSVYSGWLAYSTFDHEwvkhqiedttveevliknwpglhiEPLQAPENMEVLIGWTGSPASSPHFVSEVKRLK-SDP 244
Cdd:COG1577  142 DTAASTYGGPIYYQRGDRA------------------------EPLELPKNLPLVVGDTGVPASTKELVAKVRKLKeRNP 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539 245 SFYGDFLEDSHRCVEKLIHAFKTNNIKGVQKMVRQNRTIIQRMdkeatvDIETEKLKYLCDIAEKYHG-ASKTSGAGGGD 323
Cdd:COG1577  198 ELYEAFLEEIGDLVEEAIEALEEGDLEALGELMNENHGLLRAL------GVSTPELDRLVEAARKAGAlGAKLTGAGGGG 271

                 ...
gi 446539539 324 CGI 326
Cdd:COG1577  272 CVI 274
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
6-327 5.79e-18

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 82.72  E-value: 5.79e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539    6 APGKLYIAGEYAVTEpGYKSVLIALDRFVT-ATIEEAD--QYKGTIHSKALHHNPVTFSrdedsivisdphaaKQLNYVV 82
Cdd:TIGR00549   1 APGKIILFGEHAVVY-GEPAIAAPIPLRTTvTVIESSDgsFIESDLGRGSLDDAPDELD--------------GLKYVLA 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539   83 TAIEIFEqyakscDIAMKHFHLTIDSNLDdsngHKYGLGSSAAVLVSVIKVLNEFYDMKLSNLYIYKLAVIANMKLQSLS 162
Cdd:TIGR00549  66 EFLSRFS------ELNPPPLEITIESEIP----PGRGLGSSAAVAVALIRALADYFGSELSKEELAELANEAEKIAHGKP 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539  163 SCGDIAVSVYSGWLAYSTfdhewvkhqiedttveevliknwpGLHIEPLQAPENMEVLIGWTGSPASSPHFVSEVKRLKS 242
Cdd:TIGR00549 136 SGIDTATSTSGGPVYFEK------------------------GEGEFTKLISLDGYFVIADTGVSGSTKEAVARVRQLLE 191
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539  243 D-PSFYGDFLEDSHRCVEKLIHAFKTNNIKGVQKMVRQNRTIIQRMdkeatvDIETEKLKYLCDIAEKyHGA--SKTSGA 319
Cdd:TIGR00549 192 RfPELIDSIMDAIGELTLEAKAALQDGDVESLGELMNINQGLLKAL------GVSHPKLDQLVEIARK-AGAlgAKLTGA 264

                  ....*...
gi 446539539  320 GGGDCGIT 327
Cdd:TIGR00549 265 GGGGCMIA 272
PRK03926 PRK03926
mevalonate kinase; Provisional
1-324 6.68e-17

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 80.10  E-value: 6.68e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539   1 MIQVKAPGKLYIAGEYAVT--EPGYKSVlIALDRFVTAtieeadqykgtihskalhhnpvtfSRDEDSIVISDPH--AAK 76
Cdd:PRK03926   1 MVLCSAPGKIYLFGEHAVVygKPAIACA-IDLRTYVRA------------------------EFNDDSIYIESDYgkTGE 55
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539  77 QLNYVVTAIEIFEQYAkscdiAMKHFHLTIDSNLDDSNghkyGLGSSAAVLVSVIKVLNEFYDMKLSNLYIYKLAVIANM 156
Cdd:PRK03926  56 KHPYVSAAIEKMREEA-----DKDGVTVSITSQIPVGS----GLGSSAAVTVATIGALNRLLGLGLSLEEIAKLGHKVEL 126
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539 157 KLQSLSSCGDIAVSVYSGWLAYSTfdhewvkhqiedttveevliknwpGLHIEPLQAPenmeVLIGWTGSPASSPHFVSE 236
Cdd:PRK03926 127 LVQGAASPTDTYVSTMGGFVTIPD------------------------RKKLPFPECG----IVVGYTGSSGSTKELVAN 178
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539 237 VKRLKSD-PSFYGDFLEDSHRCVEKLIHAFKTNNIKGVQKMVRQNRTIIQrmdkeaTVDIETEKLKYLCdIAEKYHGA-- 313
Cdd:PRK03926 179 VRKLKEEyPELIEPILSSIGKISEKGEELILSGDYVSLGELMNINQGLLD------ALGVSTKELSELI-YAARTAGAlg 251
                        330
                 ....*....|.
gi 446539539 314 SKTSGAGGGDC 324
Cdd:PRK03926 252 AKITGAGGGGC 262
Pmev_kin_ERG8 TIGR01219
phosphomevalonate kinase, ERG8-type, eukaryotic branch; This enzyme is part of the mevalonate ...
6-350 1.55e-14

phosphomevalonate kinase, ERG8-type, eukaryotic branch; This enzyme is part of the mevalonate pathway, one of two alternative pathways for the biosynthesis of IPP. In an example of nonorthologous gene displacement, two different types of phosphomevalonate kinase are found - the animal type and this ERG8 type. This model represents plant and fungal forms of the ERG8 type of phosphomevalonate kinase. [Central intermediary metabolism, Other]


Pssm-ID: 273509 [Multi-domain]  Cd Length: 454  Bit Score: 74.21  E-value: 1.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539    6 APGKLYIAGEYAVTEPGYKSVLIALD-RF--VTATI-EEADQYKGTIHSKALHhnpvtFSRDEDSIVISDPHAAKQLNYV 81
Cdd:TIGR01219   4 APGKVLMAGGYLVLDKPYAGLVLGLNaRFyaIVKPInEEVGAWKWDVRVKSPQ-----FSDREWLYKISLNHLTLQSVSA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539   82 VTAIEIFEQYAksCDIAMKHFHLTIDSNLDD-------------SNG---------------------------HKYGLG 121
Cdd:TIGR01219  79 SDSRNPFVNPF--IQYAIAAVHLYFDKESLHklllqglditilgDNAyysqpeslgtlapfasitfnaaekpevAKTGLG 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539  122 SSAAVLVSVIKVLNEFY----------DMKLSNLY---IYKLAVIANMKLQSLSSCG-DIAVSVYsGWLAYSTFDHEWVK 187
Cdd:TIGR01219 157 SSAAMTTALVAALLHYLgvvdlsdpdkEGKFGCSDldvIHNLAQTAHCLAQGKVGSGfDVSAAVY-GSQRYRRFSPELIS 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539  188 HQIED-------TTVEEVLIKNWPGlHIEPLQAPENMEVLIGWTGSPASSPHFVSEVKRL-KSDPsfygdflEDSHRCVE 259
Cdd:TIGR01219 236 FLQVAitglplnEVLGTIVKGKWDN-KRTEFSLPPLMNLFMGDPGGGSSTPSMVGKVKKWqMSDP-------EESRENWQ 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539  260 KLIHAF------------------------------------KTNNIKGVQKMVRQNRTIIQRMDKEATVDIETEKLKYL 303
Cdd:TIGR01219 308 NLSDANleletklndlsklakdhwdvylrvikvltsekcvlhATEELLEAREAMLRIRRLMRQITEEASVDIEPESQTQL 387
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 446539539  304 CDIAEKYHGA--SKTSGAGGGDCGITIINKDVD-KEKIYDEWTKHGIKPL 350
Cdd:TIGR01219 388 LDSTMSLEGVllAGVPGAGGFDAIFAITLGDVDsGTKLTQAWSSHNVLAL 437
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
261-348 3.72e-11

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 58.64  E-value: 3.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539  261 LIHAFKTNNIKGVQKMVRQNRTIIQrmdKEATVDIETEKLKYLCDIAEKYHGASKTSGAGGGDCGITIINKDVDKEKIYD 340
Cdd:pfam08544   1 LLEALLRGDLEELGKLLTESAESLE---PLLVVGILPPELDELLEALLELGLGAKLSGSGGGPTVFALFKDEDDAEEVAR 77

                  ....*...
gi 446539539  341 EWTKHGIK 348
Cdd:pfam08544  78 ALREAGKK 85
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
103-174 6.01e-08

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 49.08  E-value: 6.01e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446539539  103 HLTIDSNLDdsngHKYGLGSSAAVLVSVIKVLNEFYDMKLSNL--YIYKLAVIANmklqslSSCGDIAVSVYSG 174
Cdd:pfam00288   1 DIEIESNIP----LGAGLGSSAALAVALLLALNELFGLPLAKLalEAEELAGGGR------GGGMDVAASLYGG 64
PRK03817 PRK03817
galactokinase; Provisional
2-154 1.04e-07

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 53.08  E-value: 1.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539   2 IQVKAPGKLYIAGEYAVTEPGYksVL-IALDRFVTATIEEADQYKgtIHSKALHHNpVTFSRDEdsivisdphaAKQLN- 79
Cdd:PRK03817   1 MKVKSPGRVNLIGEHTDYNDGY--VLpFAINLYTFLEIEKSEKFI--FYSENFNEE-KTFELDK----------LEKLNs 65
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446539539  80 ---YVVTAIEIFEQyaKSCDIamKHFHLTIDSNLDDSNGhkygLGSSAAVLVSVIKVLNEFYDMKLSNLYIYKLAVIA 154
Cdd:PRK03817  66 wadYIKGVIWVLEK--RGYEV--GGVKGKVSSNLPIGAG----LSSSASLEVAVAYALNEAYNLNLSKLELALLAREA 135
PRK01212 PRK01212
homoserine kinase; Provisional
21-151 8.30e-07

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 50.15  E-value: 8.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539  21 PGYKSVLIALDRFVTATIEEADQYKGTIHSKALHHNPVTFSRDEDSivisdphaakqlNYVVTAIEIFEQYAKScdiaMK 100
Cdd:PRK01212  17 PGFDSLGLALSLYDEVLVGDVVSVEAEFSIEVIGEGADKLPLDPEK------------NLVYQAALKFLEKLGK----PP 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446539539 101 HFHLTIDSNLDdsngHKYGLGSSAAVLVSVIKVLNEFYDMKLSNLYIYKLA 151
Cdd:PRK01212  81 GLRIELEKNIP----LGRGLGSSAASIVAGLVAANELAGLPLSKEELLQLA 127
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
1-152 5.49e-06

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 47.40  E-value: 5.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446539539   1 MIQVKAPGKlyIA--GeyavtePGYKSVLIALDRF--VTATIEEADQYKGTIHSKALHHNPvtfsRDEDsivisdphaak 76
Cdd:COG0083    2 SVKVRVPAT--SAnlG------PGFDSLGLALSLYdeVEVERSDEPGLEIEIEGEGADELP----TDED----------- 58
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446539539  77 qlNYVVTAieiFEQYAKSCDIAMKHFHLTIDSNLddsnGHKYGLGSSAAVLVSVIKVLNEFYDMKLSNLYIYKLAV 152
Cdd:COG0083   59 --NLVYQA---ALALLEKLGKEPPGLRIEIEKGI----PLGRGLGSSAAAIVAGLVAANALLGLPLSKEELLELAT 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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