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Conserved domains on  [gi|446536197|ref|WP_000613543|]
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PG:teichoic acid D-alanyltransferase DltB [Staphylococcus aureus]

Protein Classification

D-alanyl-lipoteichoic acid biosynthesis protein DltB( domain architecture ID 10024434)

D-alanyl-lipoteichoic acid biosynthesis protein DltB is involved in the D-alanylation of lipoteichoic acid (LTA), which plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LTA_dltB TIGR04091
D-alanyl-lipoteichoic acid biosynthesis protein DltB; Members of this protein family are DltB, ...
2-403 0e+00

D-alanyl-lipoteichoic acid biosynthesis protein DltB; Members of this protein family are DltB, part of a four-gene operon for D-alanyl-lipoteichoic acid biosynthesis that is present in the vast majority of low-GC Gram-positive organisms. This protein may be involved in transport of D-alanine across the plasma membrane. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


:

Pssm-ID: 274974  Cd Length: 380  Bit Score: 522.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197    2 IPYGDFTFFLIALIALLPVIILGFLGKRSYIYNGVVTAFMIVLIFSSDKHnlfdqkylsvQLISFIIYVVWQVLLIMFYY 81
Cdd:TIGR04091   1 TPYGNPSFFLILILALLPAIILGLFGKRFKYYELLVSLVFLVLIFGGDKW----------QLIALILYVIWQTLLVKGYL 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197   82 HSKPKNNSFSKFVTVMVLSILPLALVKVLQSTWLGGhqihfhesklieFVGFLGISYVTFKSVQLIMEIRDGSIKEIKVW 161
Cdd:TIGR04091  71 AYRKKKNSKWVFYLAVFLSILPLVLVKVSPLFPLHS------------LLGFLGISYLTFKAVQIIIEIRDGLIKEISLW 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197  162 KLIQFISFFPTISSGPIDRYKRFVKDDKKVPTGNEYRELVLKAIHMIMLGFLYKYIVAYFINTYAIMPLQLDLHGFVNLW 241
Cdd:TIGR04091 139 DFLYFLLFFPTISSGPIDRSRRFEKDYEKVPSREEYLELLGKGIHYIFLGFLYKFILAYLIGTLLLPKLEKDALFFWNLL 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197  242 LYMYAYSLYLFFDFAGYSLFAIAFSYLFGIKTPPNFDKPFKAKNIKDFWNRWHMTLSFWFRDCIYMRSLFYMSRKKLLKS 321
Cdd:TIGR04091 219 GYMYAYSFYLFFDFAGYSLFAVGISYLMGIETPMNFNKPFLSKDIKDFWNRWHISLSFWFRDFVFMRFVFFLMKKKWFKN 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197  322 QFAMSNVAFLINFFIMGIWHGIEVYYIVYGLYHATLFIGYGYYERWRKKHPPRWQNGFTTALSIVITFHFVTFGFLIFSG 401
Cdd:TIGR04091 299 RLTTSNVAYLINMLIMGFWHGLTWYYIAYGLYHGLLLALTDAWQRKSKKYKKNKKNKWTKALSIFVTFHLVCFGFLIFSG 378

                  ..
gi 446536197  402 KL 403
Cdd:TIGR04091 379 FL 380
 
Name Accession Description Interval E-value
LTA_dltB TIGR04091
D-alanyl-lipoteichoic acid biosynthesis protein DltB; Members of this protein family are DltB, ...
2-403 0e+00

D-alanyl-lipoteichoic acid biosynthesis protein DltB; Members of this protein family are DltB, part of a four-gene operon for D-alanyl-lipoteichoic acid biosynthesis that is present in the vast majority of low-GC Gram-positive organisms. This protein may be involved in transport of D-alanine across the plasma membrane. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274974  Cd Length: 380  Bit Score: 522.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197    2 IPYGDFTFFLIALIALLPVIILGFLGKRSYIYNGVVTAFMIVLIFSSDKHnlfdqkylsvQLISFIIYVVWQVLLIMFYY 81
Cdd:TIGR04091   1 TPYGNPSFFLILILALLPAIILGLFGKRFKYYELLVSLVFLVLIFGGDKW----------QLIALILYVIWQTLLVKGYL 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197   82 HSKPKNNSFSKFVTVMVLSILPLALVKVLQSTWLGGhqihfhesklieFVGFLGISYVTFKSVQLIMEIRDGSIKEIKVW 161
Cdd:TIGR04091  71 AYRKKKNSKWVFYLAVFLSILPLVLVKVSPLFPLHS------------LLGFLGISYLTFKAVQIIIEIRDGLIKEISLW 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197  162 KLIQFISFFPTISSGPIDRYKRFVKDDKKVPTGNEYRELVLKAIHMIMLGFLYKYIVAYFINTYAIMPLQLDLHGFVNLW 241
Cdd:TIGR04091 139 DFLYFLLFFPTISSGPIDRSRRFEKDYEKVPSREEYLELLGKGIHYIFLGFLYKFILAYLIGTLLLPKLEKDALFFWNLL 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197  242 LYMYAYSLYLFFDFAGYSLFAIAFSYLFGIKTPPNFDKPFKAKNIKDFWNRWHMTLSFWFRDCIYMRSLFYMSRKKLLKS 321
Cdd:TIGR04091 219 GYMYAYSFYLFFDFAGYSLFAVGISYLMGIETPMNFNKPFLSKDIKDFWNRWHISLSFWFRDFVFMRFVFFLMKKKWFKN 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197  322 QFAMSNVAFLINFFIMGIWHGIEVYYIVYGLYHATLFIGYGYYERWRKKHPPRWQNGFTTALSIVITFHFVTFGFLIFSG 401
Cdd:TIGR04091 299 RLTTSNVAYLINMLIMGFWHGLTWYYIAYGLYHGLLLALTDAWQRKSKKYKKNKKNKWTKALSIFVTFHLVCFGFLIFSG 378

                  ..
gi 446536197  402 KL 403
Cdd:TIGR04091 379 FL 380
DltB COG1696
D-alanyl-lipoteichoic acid acyltransferase DltB, MBOAT superfamily [Cell wall/membrane ...
134-399 2.38e-49

D-alanyl-lipoteichoic acid acyltransferase DltB, MBOAT superfamily [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441302 [Multi-domain]  Cd Length: 472  Bit Score: 173.48  E-value: 2.38e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197 134 LGISYVTFKSVQLIMEIRDGSIK-EIKVWKLIQFISFFPTISSGPIDRYKRFVK--DDKKVPTgneyRELVLKAIHMIML 210
Cdd:COG1696  123 LGISFYTFQAISYLVDVYRGKIKpERNFLDYALFVSFFPQLVAGPIVRAKDLLPqlRKRRTFD----YENFARGLRLFLL 198
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197 211 GFLYKYIVAYFINTYAIMPLQL-DLHGFVNLWLYMYAYSLYLFFDFAGYSLFAIAFSYLFGIKTPPNFDKPFKAKNIKDF 289
Cdd:COG1696  199 GLFKKVVIADNLAPYVDPVFDNpESLSGLEAWLGALAYTLQIYFDFSGYSDMAIGLALLFGFRLPENFNSPYFARSITEF 278
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197 290 WNRWHMTLSFWFRDCIYmRSLfYMSRKKLLKSQFAMsnvafLINFFIMGIWHGIEVYYIVYGLYHATLFIGYGYYERWRK 369
Cdd:COG1696  279 WRRWHISLSTWLRDYLY-IPL-GGNRKGKLRTYLNL-----FITMLLGGLWHGAGWTFVIWGALHGLYLVLERLWRKLRL 351
                        250       260       270
                 ....*....|....*....|....*....|
gi 446536197 370 KHPprWQNGFTTALSIVITFHFVTFGFLIF 399
Cdd:COG1696  352 KLP--RLSRLGRLLGWLLTFLLVVFAWVFF 379
MBOAT pfam03062
MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) ...
164-400 8.09e-11

MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.


Pssm-ID: 427117  Cd Length: 334  Bit Score: 62.84  E-value: 8.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197  164 IQFISFFPTISSGPIDRYKRFVK--DDKKVPTGNEYRELVLKAIHMIMLGFLYK----YIVAYFINTYAIMPL-----QL 232
Cdd:pfam03062  85 LGYVFFYPGLLVGPIFSYSDYMSfpRDPLFRWLYYVKRNLAPALGALFLGLTYLiliqYLLSHLPDKDFSKFKflsyaFL 164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197  233 DLHGFVNLWLYMYAYSLYLFFDFAGYsLFAIAFSYLFGI-------KTPPNFDKPF-KAKNIKDFWNRWHMTLSFWFRDC 304
Cdd:pfam03062 165 LRFSVIMRILLGLLWLFLLIFDFLGW-LFAEGEDILFGLgfngwdrVAPENIYRCWeNAVSFSEFWRAWNIPVHKWLKRY 243
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197  305 IYMRSLFYMSRKKLLksqfamsnvAFLINFFIMGIWHGIEVYYIVYGLYHATLFIGYGYYERWRKKHPPRwqngFTTALS 384
Cdd:pfam03062 244 VYKPLGKKGKLNKFL---------ATLATFLFSAVWHGYYLGYLLWFVLRVLLLLAEKLIRRLVRLSFLK----TDRRRP 310
                         250
                  ....*....|....*.
gi 446536197  385 IVITFHFVTFGFLIFS 400
Cdd:pfam03062 311 NLSNVIFWLGAFLGPS 326
 
Name Accession Description Interval E-value
LTA_dltB TIGR04091
D-alanyl-lipoteichoic acid biosynthesis protein DltB; Members of this protein family are DltB, ...
2-403 0e+00

D-alanyl-lipoteichoic acid biosynthesis protein DltB; Members of this protein family are DltB, part of a four-gene operon for D-alanyl-lipoteichoic acid biosynthesis that is present in the vast majority of low-GC Gram-positive organisms. This protein may be involved in transport of D-alanine across the plasma membrane. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274974  Cd Length: 380  Bit Score: 522.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197    2 IPYGDFTFFLIALIALLPVIILGFLGKRSYIYNGVVTAFMIVLIFSSDKHnlfdqkylsvQLISFIIYVVWQVLLIMFYY 81
Cdd:TIGR04091   1 TPYGNPSFFLILILALLPAIILGLFGKRFKYYELLVSLVFLVLIFGGDKW----------QLIALILYVIWQTLLVKGYL 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197   82 HSKPKNNSFSKFVTVMVLSILPLALVKVLQSTWLGGhqihfhesklieFVGFLGISYVTFKSVQLIMEIRDGSIKEIKVW 161
Cdd:TIGR04091  71 AYRKKKNSKWVFYLAVFLSILPLVLVKVSPLFPLHS------------LLGFLGISYLTFKAVQIIIEIRDGLIKEISLW 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197  162 KLIQFISFFPTISSGPIDRYKRFVKDDKKVPTGNEYRELVLKAIHMIMLGFLYKYIVAYFINTYAIMPLQLDLHGFVNLW 241
Cdd:TIGR04091 139 DFLYFLLFFPTISSGPIDRSRRFEKDYEKVPSREEYLELLGKGIHYIFLGFLYKFILAYLIGTLLLPKLEKDALFFWNLL 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197  242 LYMYAYSLYLFFDFAGYSLFAIAFSYLFGIKTPPNFDKPFKAKNIKDFWNRWHMTLSFWFRDCIYMRSLFYMSRKKLLKS 321
Cdd:TIGR04091 219 GYMYAYSFYLFFDFAGYSLFAVGISYLMGIETPMNFNKPFLSKDIKDFWNRWHISLSFWFRDFVFMRFVFFLMKKKWFKN 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197  322 QFAMSNVAFLINFFIMGIWHGIEVYYIVYGLYHATLFIGYGYYERWRKKHPPRWQNGFTTALSIVITFHFVTFGFLIFSG 401
Cdd:TIGR04091 299 RLTTSNVAYLINMLIMGFWHGLTWYYIAYGLYHGLLLALTDAWQRKSKKYKKNKKNKWTKALSIFVTFHLVCFGFLIFSG 378

                  ..
gi 446536197  402 KL 403
Cdd:TIGR04091 379 FL 380
DltB COG1696
D-alanyl-lipoteichoic acid acyltransferase DltB, MBOAT superfamily [Cell wall/membrane ...
134-399 2.38e-49

D-alanyl-lipoteichoic acid acyltransferase DltB, MBOAT superfamily [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441302 [Multi-domain]  Cd Length: 472  Bit Score: 173.48  E-value: 2.38e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197 134 LGISYVTFKSVQLIMEIRDGSIK-EIKVWKLIQFISFFPTISSGPIDRYKRFVK--DDKKVPTgneyRELVLKAIHMIML 210
Cdd:COG1696  123 LGISFYTFQAISYLVDVYRGKIKpERNFLDYALFVSFFPQLVAGPIVRAKDLLPqlRKRRTFD----YENFARGLRLFLL 198
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197 211 GFLYKYIVAYFINTYAIMPLQL-DLHGFVNLWLYMYAYSLYLFFDFAGYSLFAIAFSYLFGIKTPPNFDKPFKAKNIKDF 289
Cdd:COG1696  199 GLFKKVVIADNLAPYVDPVFDNpESLSGLEAWLGALAYTLQIYFDFSGYSDMAIGLALLFGFRLPENFNSPYFARSITEF 278
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197 290 WNRWHMTLSFWFRDCIYmRSLfYMSRKKLLKSQFAMsnvafLINFFIMGIWHGIEVYYIVYGLYHATLFIGYGYYERWRK 369
Cdd:COG1696  279 WRRWHISLSTWLRDYLY-IPL-GGNRKGKLRTYLNL-----FITMLLGGLWHGAGWTFVIWGALHGLYLVLERLWRKLRL 351
                        250       260       270
                 ....*....|....*....|....*....|
gi 446536197 370 KHPprWQNGFTTALSIVITFHFVTFGFLIF 399
Cdd:COG1696  352 KLP--RLSRLGRLLGWLLTFLLVVFAWVFF 379
MBOAT pfam03062
MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) ...
164-400 8.09e-11

MBOAT, membrane-bound O-acyltransferase family; The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue.


Pssm-ID: 427117  Cd Length: 334  Bit Score: 62.84  E-value: 8.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197  164 IQFISFFPTISSGPIDRYKRFVK--DDKKVPTGNEYRELVLKAIHMIMLGFLYK----YIVAYFINTYAIMPL-----QL 232
Cdd:pfam03062  85 LGYVFFYPGLLVGPIFSYSDYMSfpRDPLFRWLYYVKRNLAPALGALFLGLTYLiliqYLLSHLPDKDFSKFKflsyaFL 164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197  233 DLHGFVNLWLYMYAYSLYLFFDFAGYsLFAIAFSYLFGI-------KTPPNFDKPF-KAKNIKDFWNRWHMTLSFWFRDC 304
Cdd:pfam03062 165 LRFSVIMRILLGLLWLFLLIFDFLGW-LFAEGEDILFGLgfngwdrVAPENIYRCWeNAVSFSEFWRAWNIPVHKWLKRY 243
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446536197  305 IYMRSLFYMSRKKLLksqfamsnvAFLINFFIMGIWHGIEVYYIVYGLYHATLFIGYGYYERWRKKHPPRwqngFTTALS 384
Cdd:pfam03062 244 VYKPLGKKGKLNKFL---------ATLATFLFSAVWHGYYLGYLLWFVLRVLLLLAEKLIRRLVRLSFLK----TDRRRP 310
                         250
                  ....*....|....*.
gi 446536197  385 IVITFHFVTFGFLIFS 400
Cdd:pfam03062 311 NLSNVIFWLGAFLGPS 326
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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