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Conserved domains on  [gi|446533218|ref|WP_000610564|]
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MULTISPECIES: multidrug efflux transporter outer membrane subunit MdtP [Enterobacteriaceae]

Protein Classification

multidrug efflux transporter outer membrane subunit MdtP( domain architecture ID 11484521)

multidrug efflux transporter outer membrane subunit MdtP is part of a tripartite efflux system composed of MdtN, MdtO and MdtP, that may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK09915 PRK09915
MdtP family multidrug efflux transporter outer membrane subunit;
1-488 0e+00

MdtP family multidrug efflux transporter outer membrane subunit;


:

Pssm-ID: 182142 [Multi-domain]  Cd Length: 488  Bit Score: 909.26  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218   1 MINRQLSRLLLCSILGSTTLISGCALVRKDSAPHQQLKPEQIKLADDIHLASSGWPQAQWWKQLNDPQLDALIQRTLSGS 80
Cdd:PRK09915   1 MINRQLSRLLLCSILGSTTLISGCALVRKDSAPHQQLKPEQIKLADDIHLASSGWPQAQWWKQLNDPQLDALIQRTLSGS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218  81 HTLAEAKLREEKAQSQADLLDAGSQLQVAALGMLNRQRVSANGFLSPYAMDAPALGMDGPYYTEATVGLFAGLDLDLWGV 160
Cdd:PRK09915  81 HTLAEAKLREEKAQSQADLLDAGSQLQVAALGMLNRQRVSANGFLSPYAMDAPALGMDGPYYTEATVGLFAGLDLDLWGV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 161 HRSAVAAAIGAHNAALAETAAVELSLTTGVAQLYYSMQASYQMLDLLEQTRDVIDYAVKAHQSKVAHGLEAQVPFHGARA 240
Cdd:PRK09915 161 HRSAVAAAIGAHNAALAETAAVELSLTTGVAQLYYSMQASYQMLDLLEQTRDVIDYAVKAHQSKVAHGLEAQVPFHGARA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 241 QILAVDKQIAAVKGQITETRESLRALIGAGASDMPEIKPVALPQVQTGIPATLSYELLARRPDLQAMRWYVQASLDQVDS 320
Cdd:PRK09915 241 QILAVDKQIAAVKGQITETRESLRALIGAGASDMPEIKPVALPRVQTGIPATLSYELLARRPDLQAMRWYVQASLDQVDS 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 321 ARALFYPSFDIKAFFGLDAIHLDTLFKKTSRQFNFIPGLKLPLFDGGRLNANLEGTRAASNMMIERYNQSVLNAVRDVAV 400
Cdd:PRK09915 321 ARALFYPSFDIKAFFGLDAIHLDTLFKKTSRQFNFIPGLKLPLFDGGRLNANLEGTRAASNMMIERYNQSVLNAVRDVAV 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 401 NGTRLQTLNDEREMQAERVEATRFTQRAAEAAYQRGLTSRLQATEARLPVLAEEMSLLMLDSRRVIQSIQLMKSLGGGYQ 480
Cdd:PRK09915 401 NGTRLQTLNDEREMQAERVEATRFTQRAAEAAYQRGLTSRLQATEARLPVLAEEMSLLMLDSRRVIQSIQLMKSLGGGYQ 480

                 ....*...
gi 446533218 481 AAPVVEKK 488
Cdd:PRK09915 481 AAPVVEKK 488
 
Name Accession Description Interval E-value
PRK09915 PRK09915
MdtP family multidrug efflux transporter outer membrane subunit;
1-488 0e+00

MdtP family multidrug efflux transporter outer membrane subunit;


Pssm-ID: 182142 [Multi-domain]  Cd Length: 488  Bit Score: 909.26  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218   1 MINRQLSRLLLCSILGSTTLISGCALVRKDSAPHQQLKPEQIKLADDIHLASSGWPQAQWWKQLNDPQLDALIQRTLSGS 80
Cdd:PRK09915   1 MINRQLSRLLLCSILGSTTLISGCALVRKDSAPHQQLKPEQIKLADDIHLASSGWPQAQWWKQLNDPQLDALIQRTLSGS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218  81 HTLAEAKLREEKAQSQADLLDAGSQLQVAALGMLNRQRVSANGFLSPYAMDAPALGMDGPYYTEATVGLFAGLDLDLWGV 160
Cdd:PRK09915  81 HTLAEAKLREEKAQSQADLLDAGSQLQVAALGMLNRQRVSANGFLSPYAMDAPALGMDGPYYTEATVGLFAGLDLDLWGV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 161 HRSAVAAAIGAHNAALAETAAVELSLTTGVAQLYYSMQASYQMLDLLEQTRDVIDYAVKAHQSKVAHGLEAQVPFHGARA 240
Cdd:PRK09915 161 HRSAVAAAIGAHNAALAETAAVELSLTTGVAQLYYSMQASYQMLDLLEQTRDVIDYAVKAHQSKVAHGLEAQVPFHGARA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 241 QILAVDKQIAAVKGQITETRESLRALIGAGASDMPEIKPVALPQVQTGIPATLSYELLARRPDLQAMRWYVQASLDQVDS 320
Cdd:PRK09915 241 QILAVDKQIAAVKGQITETRESLRALIGAGASDMPEIKPVALPRVQTGIPATLSYELLARRPDLQAMRWYVQASLDQVDS 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 321 ARALFYPSFDIKAFFGLDAIHLDTLFKKTSRQFNFIPGLKLPLFDGGRLNANLEGTRAASNMMIERYNQSVLNAVRDVAV 400
Cdd:PRK09915 321 ARALFYPSFDIKAFFGLDAIHLDTLFKKTSRQFNFIPGLKLPLFDGGRLNANLEGTRAASNMMIERYNQSVLNAVRDVAV 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 401 NGTRLQTLNDEREMQAERVEATRFTQRAAEAAYQRGLTSRLQATEARLPVLAEEMSLLMLDSRRVIQSIQLMKSLGGGYQ 480
Cdd:PRK09915 401 NGTRLQTLNDEREMQAERVEATRFTQRAAEAAYQRGLTSRLQATEARLPVLAEEMSLLMLDSRRVIQSIQLMKSLGGGYQ 480

                 ....*...
gi 446533218 481 AAPVVEKK 488
Cdd:PRK09915 481 AAPVVEKK 488
outer_NodT TIGR01845
efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this ...
15-478 2.74e-68

efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this model comprise a subfamily of the Outer Membrane Factor (TCDB 1.B.17) porins. OMF proteins operate in conjunction with a primary transporter of the RND, MFS, ABC, or PET systems, and a MFP (membrane fusion protein) to tranport substrates across membranes. The complex thus formed allows transport (export) of various solutes (heavy metal cations; drugs, oligosaccharides, proteins, etc.) across the two envelopes of the Gram-negative bacterial cell envelope in a single energy-coupled step. Current data suggest that the OMF (and not the MFP) is largely responsible for the formation of both the trans-outer membrane and trans-periplasmic channels. The roles played by the MFP have yet to be determined. [Cellular processes, Detoxification, Transport and binding proteins, Porins]


Pssm-ID: 273830 [Multi-domain]  Cd Length: 460  Bit Score: 225.75  E-value: 2.74e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218   15 LGSTTLISGCALVRKDSAPH----QQLKPEQIKLADDIHLASSGWPQAQWWKQLNDPQLDALIQRTLSGSHTLAEAKLRE 90
Cdd:TIGR01845   1 LAAALLLSGCAVGPDYARPEtplaAGYLESDPTFGGQGRLSAGVWPAVDWWTAFGDPQLNALIEEALADNPDLQVAEARL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218   91 EKAQSQADLLDAGSQLQVAALGMLNRQRVSAngflspyamDAPALGMDGPYYTEATVGLFAGLDLDLWGVHRSAVAAAIG 170
Cdd:TIGR01845  81 RAARANLRAARADFFPSLGLSASATRQKSSE---------DASGTTSGGSLSNTSTLTLDVSYELDLFGKVRRAVESALA 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218  171 AHNAALAETAAVELSLTTGVAQLYYSMQASYQMLDLLEQTRDVIDYAVKAHQSKVAHGLEAQVPFHGARAQILAVDKQIA 250
Cdd:TIGR01845 152 QLEAAEADSQAARLTLSASIANAYVQLAALRAQLDVYHAALASRRKTLELTQKRYAAGVAAASDVRQAEAAVASAEAELP 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218  251 AVKGQITETRESLRALIGAGASDMPEI-KPVALPQVQTGIPATLSYELLARRPDLQAMRWYVQASLDQVDSARALFYPSF 329
Cdd:TIGR01845 232 SLDVQIAQARNALAALLGKGPSRGLAIaRPLLLDQLPPDLPLSLPSDLLRRRPDIRAAERRLAAANAQIGVAKAAFFPSI 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218  330 DIKAFFGLDAIHLDTLFKKTSRQFNFIPGLKLPLFDGGRLNANLEGTRAASNMMIERYNQSVLNAVRDVAVNGTRLQTLN 409
Cdd:TIGR01845 312 TLSASIGLSASQLSRLFDGGSRFWSIGPALALPIFDGGSLRAALDSAKATYDAAVAQYRQTVLTAFQEVADALVALQALA 391
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446533218  410 DEREMQAERVEATRFTQRAAEAAYQRGLTSRLQATEARLPVLAEEMSLLMLDSRRVIQSIQLMKSLGGG 478
Cdd:TIGR01845 392 RRLDAQRQAVEQAQEALSLAQTRYRAGLDSYLTVLEAQRSLLTAQRSLATLQARRLSDSVALYKALGGG 460
TolC COG1538
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];
142-480 4.18e-40

Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441147 [Multi-domain]  Cd Length: 367  Bit Score: 148.26  E-value: 4.18e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 142 YTEATVGLFAGLDLDLWGVHRSAVAAAIGAHNAALAETAAVELSLTTGVAQLYYSMQASYQMLDLLEQTRDVIDYAVKAH 221
Cdd:COG1538   30 LRQARAGLLPSQELDLGGKRRARIEAAKAQAEAAEADLRAARLDLAAEVAQAYFDLLAAQEQLALAEENLALAEELLELA 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 222 QSKVAHGLEAQVPFHGARAQILAVDKQIAAVKGQITETRESLRALIGAGASDMPEIKP--VALPQVQTGIPATLSyELLA 299
Cdd:COG1538  110 RARYEAGLASRLDVLQAEAQLAQARAQLAQAEAQLAQARNALALLLGLPPPAPLDLPDplPPLPPLPPSLPGLPS-EALE 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 300 RRPDLQAMRWYVQASLDQVDSARALFYPSFDIKAFFGLDAihLDTLFKKTSRQFNFIPGLKLPLFDGGRLNANLEGTRAA 379
Cdd:COG1538  189 RRPDLRAAEAQLEAAEAEIGVARAAFLPSLSLSASYGYSS--SDDLFSGGSDTWSVGLSLSLPLFDGGRNRARVRAAKAQ 266
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 380 SNMMIERYNQSVLNAVRDVAVNGTRLQTLNDEREMQAERVEATRFTQRAAEAAYQRGLTSRLQATEARLPVLAEEMSLLM 459
Cdd:COG1538  267 LEQAEAQYEQTVLQALQEVEDALAALRAAREQLEALEEALEAAEEALELARARYRAGLASLLDVLDAQRELLQAQLNLIQ 346
                        330       340
                 ....*....|....*....|.
gi 446533218 460 LDSRRVIQSIQLMKSLGGGYQ 480
Cdd:COG1538  347 ARYDYLLALVQLYRALGGGWE 367
OEP pfam02321
Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric ...
298-476 1.31e-09

Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.


Pssm-ID: 396757 [Multi-domain]  Cd Length: 181  Bit Score: 57.53  E-value: 1.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218  298 LARRPDLQAMRWYVQASLDQVDSARALFYPSFDIKAFFGLDAiHLDTLFKKTSRQFNFIPGLKLPLFDGGRLNANLEGTR 377
Cdd:pfam02321   4 LENNPDLKAAEAEIEAAEANIKLAKSEFLPDLSLSGGYGYNS-NNSESGGDDPGTGEVGLGLSQPLFDGGKRRARVKAAK 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218  378 AASNMMIERYNQSVLNAVRDVAVNGTRLQTLNDEREMQAERVEATRFTQRAAEAAYQRGLTSRLQATEARLPVLAEEMSL 457
Cdd:pfam02321  83 AQVEAAEAQLEQARQQLRLEVAQAYLQLLAAKEQLELAEQALELAEEALELAEARYEAGLISLLDVLQAEVELLEARLEL 162
                         170
                  ....*....|....*....
gi 446533218  458 LMLDSRRVIQSIQLMKSLG 476
Cdd:pfam02321 163 LNAEADLELALAQLEQLLG 181
 
Name Accession Description Interval E-value
PRK09915 PRK09915
MdtP family multidrug efflux transporter outer membrane subunit;
1-488 0e+00

MdtP family multidrug efflux transporter outer membrane subunit;


Pssm-ID: 182142 [Multi-domain]  Cd Length: 488  Bit Score: 909.26  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218   1 MINRQLSRLLLCSILGSTTLISGCALVRKDSAPHQQLKPEQIKLADDIHLASSGWPQAQWWKQLNDPQLDALIQRTLSGS 80
Cdd:PRK09915   1 MINRQLSRLLLCSILGSTTLISGCALVRKDSAPHQQLKPEQIKLADDIHLASSGWPQAQWWKQLNDPQLDALIQRTLSGS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218  81 HTLAEAKLREEKAQSQADLLDAGSQLQVAALGMLNRQRVSANGFLSPYAMDAPALGMDGPYYTEATVGLFAGLDLDLWGV 160
Cdd:PRK09915  81 HTLAEAKLREEKAQSQADLLDAGSQLQVAALGMLNRQRVSANGFLSPYAMDAPALGMDGPYYTEATVGLFAGLDLDLWGV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 161 HRSAVAAAIGAHNAALAETAAVELSLTTGVAQLYYSMQASYQMLDLLEQTRDVIDYAVKAHQSKVAHGLEAQVPFHGARA 240
Cdd:PRK09915 161 HRSAVAAAIGAHNAALAETAAVELSLTTGVAQLYYSMQASYQMLDLLEQTRDVIDYAVKAHQSKVAHGLEAQVPFHGARA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 241 QILAVDKQIAAVKGQITETRESLRALIGAGASDMPEIKPVALPQVQTGIPATLSYELLARRPDLQAMRWYVQASLDQVDS 320
Cdd:PRK09915 241 QILAVDKQIAAVKGQITETRESLRALIGAGASDMPEIKPVALPRVQTGIPATLSYELLARRPDLQAMRWYVQASLDQVDS 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 321 ARALFYPSFDIKAFFGLDAIHLDTLFKKTSRQFNFIPGLKLPLFDGGRLNANLEGTRAASNMMIERYNQSVLNAVRDVAV 400
Cdd:PRK09915 321 ARALFYPSFDIKAFFGLDAIHLDTLFKKTSRQFNFIPGLKLPLFDGGRLNANLEGTRAASNMMIERYNQSVLNAVRDVAV 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 401 NGTRLQTLNDEREMQAERVEATRFTQRAAEAAYQRGLTSRLQATEARLPVLAEEMSLLMLDSRRVIQSIQLMKSLGGGYQ 480
Cdd:PRK09915 401 NGTRLQTLNDEREMQAERVEATRFTQRAAEAAYQRGLTSRLQATEARLPVLAEEMSLLMLDSRRVIQSIQLMKSLGGGYQ 480

                 ....*...
gi 446533218 481 AAPVVEKK 488
Cdd:PRK09915 481 AAPVVEKK 488
PRK11459 PRK11459
multidrug resistance outer membrane protein MdtQ; Provisional
19-480 9.24e-99

multidrug resistance outer membrane protein MdtQ; Provisional


Pssm-ID: 183143 [Multi-domain]  Cd Length: 478  Bit Score: 305.33  E-value: 9.24e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218  19 TLISGCALVRKDSAPHQQLKPEQIKLADDIHLASSGWPQAQWWKQLNDPQLDALIQRTLSGSHTLAEAKLREEKAQSQAD 98
Cdd:PRK11459  17 IMLAGCAPMHETRQALSQQTPAAHVDTALPTALKNGWPDSQWWKAYHDNQLDSLINNALQNAPDMQVAEQRIQLAEAQAK 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218  99 LLDAGSQLQVAALGMLNRQRVSANGFLSPYAMDAPALGMDGPYYTEATVGLFAGLDLDLWGVHRSAVAAAIGAHNAALAE 178
Cdd:PRK11459  97 AVAAQDGPQLDFSADMERQKMSAEGLMGPFALNDPAAGTTGPWYTNGTFGLTAGWDLDLWGKNRAEVTARIGTVKARAAE 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 179 TAAVELSLTTGVAQLYYSMQASYQMLDLLEQTRDVIDYAVKAHQSKVAHGLEAQVpfHGARAQILA--VDKQIAAVKGQI 256
Cdd:PRK11459 177 REQTRQLLAGSVARLYWEWQTQAALNTVLQQIEKEQNNIIATDRQLYQNGITSSV--EGVETDINAskTRQQLNDVAGKM 254
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 257 TETRESLRALIGAGASDMpEIKPVALPQVQTGIPATLSYELLARRPDLQAMRWYVQASLDQVDSARALFYPSFDIKAFFG 336
Cdd:PRK11459 255 KIIEARLSALTNTQTKSL-KLKPVALPKVASQLPDELGYSLLARRADLQAAHWYIESSLSTIDAAKAAFYPDINLMAFLQ 333
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 337 LDAIHLDTLFKKTSRQFNFIPGLKLPLFDGGRLNANLEGTRAASNMMIERYNQSVLNAVRDVAVNGTRLQTLNDEREMQA 416
Cdd:PRK11459 334 QDALHLSDLFRHSAQQMGVTAGLTLPIFDSGRLNANLDIAKAQSNLSIASYNKAVVDAVNDVARAASQVETLAEKNQHQQ 413
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446533218 417 ERVEATRFTQRAAEAAYQRGLTSRLQATEARLPVLAEEMSLLMLDSRRVIQSIQLMKSLGGGYQ 480
Cdd:PRK11459 414 QIERDALRVVGLAQARFNAGIIAGSRVSEAKIPALRERANGLLLQGQWLDASIQLTSALGGGYH 477
outer_NodT TIGR01845
efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this ...
15-478 2.74e-68

efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Members of this model comprise a subfamily of the Outer Membrane Factor (TCDB 1.B.17) porins. OMF proteins operate in conjunction with a primary transporter of the RND, MFS, ABC, or PET systems, and a MFP (membrane fusion protein) to tranport substrates across membranes. The complex thus formed allows transport (export) of various solutes (heavy metal cations; drugs, oligosaccharides, proteins, etc.) across the two envelopes of the Gram-negative bacterial cell envelope in a single energy-coupled step. Current data suggest that the OMF (and not the MFP) is largely responsible for the formation of both the trans-outer membrane and trans-periplasmic channels. The roles played by the MFP have yet to be determined. [Cellular processes, Detoxification, Transport and binding proteins, Porins]


Pssm-ID: 273830 [Multi-domain]  Cd Length: 460  Bit Score: 225.75  E-value: 2.74e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218   15 LGSTTLISGCALVRKDSAPH----QQLKPEQIKLADDIHLASSGWPQAQWWKQLNDPQLDALIQRTLSGSHTLAEAKLRE 90
Cdd:TIGR01845   1 LAAALLLSGCAVGPDYARPEtplaAGYLESDPTFGGQGRLSAGVWPAVDWWTAFGDPQLNALIEEALADNPDLQVAEARL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218   91 EKAQSQADLLDAGSQLQVAALGMLNRQRVSAngflspyamDAPALGMDGPYYTEATVGLFAGLDLDLWGVHRSAVAAAIG 170
Cdd:TIGR01845  81 RAARANLRAARADFFPSLGLSASATRQKSSE---------DASGTTSGGSLSNTSTLTLDVSYELDLFGKVRRAVESALA 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218  171 AHNAALAETAAVELSLTTGVAQLYYSMQASYQMLDLLEQTRDVIDYAVKAHQSKVAHGLEAQVPFHGARAQILAVDKQIA 250
Cdd:TIGR01845 152 QLEAAEADSQAARLTLSASIANAYVQLAALRAQLDVYHAALASRRKTLELTQKRYAAGVAAASDVRQAEAAVASAEAELP 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218  251 AVKGQITETRESLRALIGAGASDMPEI-KPVALPQVQTGIPATLSYELLARRPDLQAMRWYVQASLDQVDSARALFYPSF 329
Cdd:TIGR01845 232 SLDVQIAQARNALAALLGKGPSRGLAIaRPLLLDQLPPDLPLSLPSDLLRRRPDIRAAERRLAAANAQIGVAKAAFFPSI 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218  330 DIKAFFGLDAIHLDTLFKKTSRQFNFIPGLKLPLFDGGRLNANLEGTRAASNMMIERYNQSVLNAVRDVAVNGTRLQTLN 409
Cdd:TIGR01845 312 TLSASIGLSASQLSRLFDGGSRFWSIGPALALPIFDGGSLRAALDSAKATYDAAVAQYRQTVLTAFQEVADALVALQALA 391
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446533218  410 DEREMQAERVEATRFTQRAAEAAYQRGLTSRLQATEARLPVLAEEMSLLMLDSRRVIQSIQLMKSLGGG 478
Cdd:TIGR01845 392 RRLDAQRQAVEQAQEALSLAQTRYRAGLDSYLTVLEAQRSLLTAQRSLATLQARRLSDSVALYKALGGG 460
TolC COG1538
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];
142-480 4.18e-40

Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441147 [Multi-domain]  Cd Length: 367  Bit Score: 148.26  E-value: 4.18e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 142 YTEATVGLFAGLDLDLWGVHRSAVAAAIGAHNAALAETAAVELSLTTGVAQLYYSMQASYQMLDLLEQTRDVIDYAVKAH 221
Cdd:COG1538   30 LRQARAGLLPSQELDLGGKRRARIEAAKAQAEAAEADLRAARLDLAAEVAQAYFDLLAAQEQLALAEENLALAEELLELA 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 222 QSKVAHGLEAQVPFHGARAQILAVDKQIAAVKGQITETRESLRALIGAGASDMPEIKP--VALPQVQTGIPATLSyELLA 299
Cdd:COG1538  110 RARYEAGLASRLDVLQAEAQLAQARAQLAQAEAQLAQARNALALLLGLPPPAPLDLPDplPPLPPLPPSLPGLPS-EALE 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 300 RRPDLQAMRWYVQASLDQVDSARALFYPSFDIKAFFGLDAihLDTLFKKTSRQFNFIPGLKLPLFDGGRLNANLEGTRAA 379
Cdd:COG1538  189 RRPDLRAAEAQLEAAEAEIGVARAAFLPSLSLSASYGYSS--SDDLFSGGSDTWSVGLSLSLPLFDGGRNRARVRAAKAQ 266
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 380 SNMMIERYNQSVLNAVRDVAVNGTRLQTLNDEREMQAERVEATRFTQRAAEAAYQRGLTSRLQATEARLPVLAEEMSLLM 459
Cdd:COG1538  267 LEQAEAQYEQTVLQALQEVEDALAALRAAREQLEALEEALEAAEEALELARARYRAGLASLLDVLDAQRELLQAQLNLIQ 346
                        330       340
                 ....*....|....*....|.
gi 446533218 460 LDSRRVIQSIQLMKSLGGGYQ 480
Cdd:COG1538  347 ARYDYLLALVQLYRALGGGWE 367
PRK09837 PRK09837
Cu(I)/Ag(I) efflux RND transporter outer membrane protein;
4-481 4.39e-35

Cu(I)/Ag(I) efflux RND transporter outer membrane protein;


Pssm-ID: 182103 [Multi-domain]  Cd Length: 461  Bit Score: 136.54  E-value: 4.39e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218   4 RQLSRLLLCSILGSTTLISGCALVRKDSAPhqqlKPEQIKLADDIHLASSGWPQAQWWKQL-NDPQLDALIQRTLSGSHT 82
Cdd:PRK09837   2 SPCKLLPFSVALALTGCVSLAPDYQRPAMP----VPQQFSLSQNGLVNAADNYQNTGWRTFfVDNQVKTLISEALVNNRD 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218  83 LAEAKLREEKAQSQADLLDAGSQLQVAALGMLNRQrvsangflspyamdAPALGmDGPYYTEATVGLFAGLDLDLWGVHR 162
Cdd:PRK09837  78 LRMATLKVQEARAQYRLTDADRYPQLNGEGSGSWS--------------GNLKG-DTATTREYSTGLNLSFDLDFFGRLK 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 163 SAVAAAIGAHNAALAETAAVELSLTTGVAQLYYSMQASYQMLDLLEQTRDVIDYAVKAHQSKVAHGLEAQVPFHGARAQI 242
Cdd:PRK09837 143 NMSEAERQNYLASEEAQRAVHILLVSNVAQSYFNQQLAYAQLQIAEETLRNYQQSYAFVEKQLLTGSSNVLALEQARGVI 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 243 LAVDKQIAAVKGQITETRESLRALIG-------AGASDMPEIKPVALPqvqtgipATLSYELLARRPDLQAMRWYVQASL 315
Cdd:PRK09837 223 ESTRADIAKRQGELAQANNALQLLLGsygklpqAQTVNSDSLQSVKLP-------AGLSSQILLQRPDIMEAEHALMAAN 295
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 316 DQVDSARALFYPSFDIKAFFGLDAIHLDTLFKKTSRQFNFIPGLKLPLFDGGRLNANLEGTRAASNMMIERYNQSVLNAV 395
Cdd:PRK09837 296 ANIGAARAAFFPSISLTSGLSTSSSDLSSLFNASSGMWNFIPKIEIPIFNAGRNQANLDLAEIRQQQSVVNYEQKIQNAF 375
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218 396 RDVAVNGTRLQTLNDEREMQAERVEATRFTQRAAEAAYQRGLTSRLQATEARLPVLAEEMSLLMLDSRRVIQSIQLMKSL 475
Cdd:PRK09837 376 KEVADALALRQSLNDQISAQQRYLASLQITLQRARALYQHGAVSYLEVLDAERSLFATRQTLLDLNYARQVNEISLFTAL 455

                 ....*.
gi 446533218 476 GGGYQA 481
Cdd:PRK09837 456 GGGWQE 461
OEP pfam02321
Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric ...
298-476 1.31e-09

Outer membrane efflux protein; The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.


Pssm-ID: 396757 [Multi-domain]  Cd Length: 181  Bit Score: 57.53  E-value: 1.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218  298 LARRPDLQAMRWYVQASLDQVDSARALFYPSFDIKAFFGLDAiHLDTLFKKTSRQFNFIPGLKLPLFDGGRLNANLEGTR 377
Cdd:pfam02321   4 LENNPDLKAAEAEIEAAEANIKLAKSEFLPDLSLSGGYGYNS-NNSESGGDDPGTGEVGLGLSQPLFDGGKRRARVKAAK 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218  378 AASNMMIERYNQSVLNAVRDVAVNGTRLQTLNDEREMQAERVEATRFTQRAAEAAYQRGLTSRLQATEARLPVLAEEMSL 457
Cdd:pfam02321  83 AQVEAAEAQLEQARQQLRLEVAQAYLQLLAAKEQLELAEQALELAEEALELAEARYEAGLISLLDVLQAEVELLEARLEL 162
                         170
                  ....*....|....*....
gi 446533218  458 LMLDSRRVIQSIQLMKSLG 476
Cdd:pfam02321 163 LNAEADLELALAQLEQLLG 181
type_I_sec_TolC TIGR01844
type I secretion outer membrane protein, TolC family; Members of this model are outer membrane ...
190-433 4.67e-08

type I secretion outer membrane protein, TolC family; Members of this model are outer membrane proteins from the TolC subfamily within the RND (Resistance-Nodulation-cell Division) efflux systems. These proteins, unlike the NodT subfamily, appear not to be lipoproteins. All are believed to participate in type I protein secretion, an ABC transporter system for protein secretion without cleavage of a signal sequence, although they may, like TolC, participate also in the efflux of smaller molecules as well. This family includes the well-documented examples TolC (E. coli), PrtF (Erwinia), and AprF (Pseudomonas aeruginosa). [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Porins]


Pssm-ID: 273829 [Multi-domain]  Cd Length: 415  Bit Score: 55.07  E-value: 4.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218  190 VAQLYYSMQASYQMLDLLEQTRDVIDYAVKAHQSKVAHGLEAQVPFHGARAQILAVDKQIAAVKGQITETRESLRALIGa 269
Cdd:TIGR01844 115 TAEAYMEVLRAQEILALAEANLAALKEQLDLARARFDVGLGTRTDVLQAEARYASARAQLIQAQNNLDDAKAQLRRLVG- 193
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218  270 gasdMPEIKPVALPQVQTGIPATLSYEL---LARRPDLQAMRWYVQASLDQVDSARALFYPSFDIKAFFGLDAIHLDTLF 346
Cdd:TIGR01844 194 ----QPELAPLAVPSFPAELPEPLDQLLeiaEASNPLLLAAQAAVDAARYQVEQARAGHLPTLSLTASTGNSDTSSGGSG 269
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446533218  347 KKTSRQFNFIPGLKLPLFDGGRLNANlegTRAASnmmiERYNQS---VLNAVRDVaVNGTRLQTLNdeREMQAERVEATR 423
Cdd:TIGR01844 270 NSDSDTYSVGLNVSIPLYQGGATSAQ---VRQAA----HQLNQSrstLESQKRTV-RQQVRNAWSN--LNAAAASVQAYE 339
                         250
                  ....*....|
gi 446533218  424 FTQRAAEAAY 433
Cdd:TIGR01844 340 QQVASAQKAL 349
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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