|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
15-392 |
1.64e-44 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 158.58 E-value: 1.64e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 15 WLSQFIAIAGLTVLVPLLPIYMASLQNLSVVEIQLWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLF 94
Cdd:cd17391 2 WLGNFFTGIGFSLIAPFLPLYIEQLGVTSGGLVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 95 LMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSA------ 168
Cdd:cd17391 82 LMAFVTNVWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNvffitg 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 169 ---LLMSIAVITFIVCIFGALKLIETTHMPKSQTPNINKGIRRSFQCLLCTQQTCRFIIVGVLANFamygmltaLSPLAS 245
Cdd:cd17391 162 gllFLAFLLTLFFVKEDFKPVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLY--------IRQLMG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 246 SVNHTAIddrsVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSA 325
Cdd:cd17391 234 DASNLAF----ISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGG 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446532703 326 LIQSVMFVVVNACHQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYTTPATTFIVMGIVFAVSSLFL 392
Cdd:cd17391 310 LLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWS 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
14-393 |
1.48e-39 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 145.41 E-value: 1.48e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 14 LWLSQFIAIAGLTVLVPLLPIYMASLqNLSVVEIqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCL 93
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESL-GASVAQI----GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVST 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 94 FLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAED-RGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMS 172
Cdd:cd17325 76 LLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEeRGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 173 IAVITFIvCIFGALKLIETTHMPKSQTPNINKGIRRSFQCLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASSVNHTai 252
Cdd:cd17325 156 CAALALL-ALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGL-- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 253 dDRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMF 332
Cdd:cd17325 233 -SPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLA 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446532703 333 VVVNACHQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYTTPATTFIVMGIVFAVSSLFLI 393
Cdd:cd17325 312 LLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
8-358 |
2.91e-31 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 122.39 E-value: 2.91e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 8 RSNFRILWLSQFIAIAGLTVLVPLLPIYMASLqNLSVVEIQLwsgiAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALL 87
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGL----VVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 88 GLAVCLFLMALCTTPLQFVLVRLLQGLFGGVV-DASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGF 166
Cdd:COG2814 84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALfPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 167 SALLMSIAVITFIVCIFGALKLIETTHMPKSQtpninkgIRRSFQCLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASS 246
Cdd:COG2814 164 RWVFLVNAVLALLALLLLLRLLPESRPAARAR-------LRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 247 VNHTaidDRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSAL 326
Cdd:COG2814 237 VLGL---SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLL 313
|
330 340 350
....*....|....*....|....*....|..
gi 446532703 327 IQSVMFVVVNACHQQLKGTFVGTTNSMLVIGQ 358
Cdd:COG2814 314 FPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
7-385 |
7.84e-31 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 122.34 E-value: 7.84e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 7 WRSNFRILWLSQFIAIAGLTVLVPLLPIYMASLQNLSVVEIQLWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRAL 86
Cdd:PRK09874 12 WKRNLTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 87 LGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGF 166
Cdd:PRK09874 92 LGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 167 SALLMSIAVITFIvCIFGALKLIETTHMPKSQTPNINkgIRRSFQCLLCTQQTCRFIIVGVLANFAMYGMLTALS----P 242
Cdd:PRK09874 172 RPVFFITASVLFL-CFLVTLFCIRENFQPVSKKEMLH--MREVVTSLKNPKLVLSLFVTTLIIQVATGSIAPILTlyvrE 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 243 LASSVNHTAIddrsVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLT 322
Cdd:PRK09874 249 LAGNVSNIAF----ISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAA 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446532703 323 YSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVIGQIIGSLSGAAIT-SYTTPATTFIVMGIVF 385
Cdd:PRK09874 325 DGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISaNYGFRAVFLVTAGVVL 388
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
14-362 |
3.10e-25 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 105.19 E-value: 3.10e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 14 LWLSQFIAIAGLTVLVPLLPIYMASLQNLSVVEIqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCL 93
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEI----GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 94 FLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAP-AEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMS 172
Cdd:pfam07690 77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 173 IAVITFIVCIFGALKLIETTHMPKSQTPNINKGIRRSFQCLLcTQQTCRFIIVGVLANFAMYGMLTALSPLASSVNHTAI 252
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALL-RDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSAL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 253 DdrsvIGFLQSAFWTASILSAPLWGRFNDK---SYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQS 329
Cdd:pfam07690 236 L----AGLLLGLGGLLGAIGRLLLGRLSDRlgrRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPA 311
|
330 340 350
....*....|....*....|....*....|...
gi 446532703 330 VMFVVVNACHQQLKGTFVGTTNSMLVIGQIIGS 362
Cdd:pfam07690 312 LNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
14-392 |
3.19e-22 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 96.88 E-value: 3.19e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 14 LWLSQFIAIAGLTVLVPLLPIYMASLQNLSVVEIQlwSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCL 93
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASGYY--VGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 94 FLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSI 173
Cdd:cd17330 79 VLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 174 AVITFIVCIFgalklietthmpksqtpninkgirrsfqCLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASSVNHtaiD 253
Cdd:cd17330 159 AALALLNLVL----------------------------VLFFLPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFG---F 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 254 DRSVIGFLQSAFWTASILS-APLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMF 332
Cdd:cd17330 208 SPSQIGLLLALVGIAGILAqLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSA 287
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 333 VVVNACHQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYTTPATTFIVMGIVFAVSSLFL 392
Cdd:cd17330 288 LLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLL 347
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
14-393 |
7.28e-22 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 96.12 E-value: 7.28e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 14 LWLSQFIAIAGLTVLVPLLPIYMASLQNLSVVeiqlwSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCL 93
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAV-----AGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALAT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 94 FLMALCTTPLQFVLVRLLQGL-FGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMS 172
Cdd:cd17489 76 LLYLLATSVALLLVLRLIHGIgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 173 IAVITFIVCIFGAlkLIETTHMPKSQTPNINKGIRRSFQCLLCTqqtcRFIIVGVLANFAMYGMLTALSPLASSVNHtai 252
Cdd:cd17489 156 AAVLALLALLLVF--LVKDPPPVAAEEAEAGTRAFRRLVEKKVL----PPALILFLASIAYGAISTFLPLYAAERGI--- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 253 ddrSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMF 332
Cdd:cd17489 227 ---SNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQA 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446532703 333 VVVNACHQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYTTPATTFIVMGIVFAVSSLFLI 393
Cdd:cd17489 304 LAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
13-393 |
9.87e-22 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 95.69 E-value: 9.87e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 13 ILWLSQFIAIAGLTVLVPLLPIYMASLqNLSVVEIqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVC 92
Cdd:cd17324 3 ALALAAFAIGTTEYVIQGLLPDIARDF-GVSVAQA----GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 93 LFLMALCTTPLQFVLVRLLQGLF-GGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLM 171
Cdd:cd17324 78 NLLAALAPSFALLLLARALAGLAhGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 172 SIAVITFIVCIFGALKLIETTHMPKSQTPNInkgirRSFQCLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASSVNHTa 251
Cdd:cd17324 158 AIAVLALLAALLLWRLLPSLPPKKPGSLGLL-----SSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGF- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 252 idDRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSAlIQSVM 331
Cdd:cd17324 232 --SSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFA-AHSAL 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446532703 332 FVVVNACHQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYTTPATTFIVMGIVFAVSSLFLI 393
Cdd:cd17324 309 QTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
14-392 |
4.81e-21 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 94.03 E-value: 4.81e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 14 LWLSQFIAIAGLTVLVPLLPIYMASLQNLSVveiqlWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCL 93
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSAS-----QLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 94 FLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAED-RGKVLGRLQSSVSAGSLVGPLIGGVTASILGFS--ALL 170
Cdd:cd06174 76 LLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPEReRGRALGLLQAFGSVGGILGPLLGGILASSLGFGwrAVF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 171 MSIAVITFIVCIFGALKLIETTHMPKSQT-PNINKGIRRSFQCLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASSVNH 249
Cdd:cd06174 156 LIAAALALLAAILLLLVVPDPPESARAKNeEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 250 TAIddrSVIGFLQSAFWTASILSAPLWGRFNDK-SYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQ 328
Cdd:cd06174 236 LSV---AVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLP 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446532703 329 SVMFVVVNACHQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYTTPATTFIVMGIVFAVSSLFL 392
Cdd:cd06174 313 LSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
13-393 |
1.23e-19 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 89.54 E-value: 1.23e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 13 ILWLSQFIAIAGLTVLVPLLPIYMASLqNLSVVEIqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVC 92
Cdd:COG2271 14 LLFLAYFLNYLDRSNLSVAAPPLQADL-GLSAAQL----GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 93 LFLMALCTTPLQFVLVRLLQGLF-GGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLM 171
Cdd:COG2271 89 TLLFGFATSFWQLLLLRFLLGLGeAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 172 SIAVITFIVCIFgalklietthmpksqtpninkgirrsfqcllctqQTCRFIIVGVLANFAMYGMLTALSPLASSVNHTa 251
Cdd:COG2271 169 ILGLPGLLLALL----------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGL- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 252 idDRSVIGFLQSAFWTASILSAPLWGRFNDK--SYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQS 329
Cdd:COG2271 214 --SLAQAGLLLSLPFLAGIVGSLLGGWLSDRlgRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGL 291
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446532703 330 VMFVVVNACHQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYTTPATTFIVMGIVFAVSSLFLI 393
Cdd:COG2271 292 LWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLAL 355
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
8-180 |
2.42e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 83.01 E-value: 2.42e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 8 RSNFRILWLSQFIAIAGLTVLVPLLPIYMASLQNLSVVEIqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALL 87
Cdd:cd17325 198 DRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQI----GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLL 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 88 GLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAED-RGKVLGRLQSSVSAGSLVGPLIGGVTASILGF 166
Cdd:cd17325 274 LSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEgRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGF 353
|
170
....*....|....
gi 446532703 167 SALLMSIAVITFIV 180
Cdd:cd17325 354 ATPFLAAAALLLLA 367
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
11-395 |
2.72e-17 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 83.05 E-value: 2.72e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 11 FRILWLSQFIAIAGLTVLVPLLPIYMASLQNLSvveiqLWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLA 90
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSA-----LLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 91 VCLFLMALCT-----TPLQFVLVRLLQGLFGGVVDASSAFASAEAPAEDR-GKVLGRLQSSVSAGSLVGPLIGGVTASIL 164
Cdd:cd06173 76 LLAAVLALLAllgslSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQlVRANALNSLATQLARIIGPALGGLLVALL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 165 GFsALLMSIAVITFIVCIFGALKLIETTHMPKSQTPNINKGIRRSFQCLLCTQQTCRFIIVGVLANFAMYGMLTALSPLA 244
Cdd:cd06173 156 GP-GGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 245 SSVNHTAidDRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYS 324
Cdd:cd06173 235 AKEVLGG--GAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGG 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446532703 325 ALIQSVMFVVVNACHQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYTTPATTFIVMGIVFAVSSLFLICS 395
Cdd:cd06173 313 LFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
13-394 |
2.81e-16 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 79.92 E-value: 2.81e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 13 ILWLSQFIAIAGLTVLVPLLPIYMASLqNLSVVEIqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVC 92
Cdd:cd17474 3 AVFFATLLAVLGVSIVDPILPAIAEAL-GASPAQV----GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 93 LFLMALCTTPLQFVLVRLLQGL-FGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLM 171
Cdd:cd17474 78 GLLCGLSDSFALLLAGRALQGIgAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 172 SIAVItfIVCIFGALKLIETthmPKSQTPNINKGIRRSFQCLLCTQQTCRFIIVGVLANFAMYGMLTALSPLAssvNHTA 251
Cdd:cd17474 158 LAALI--PVAFLAILFLLPE---PKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLL---ELLY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 252 IDDRSVIGFLQSAFWTASILSAPLWGRFNDKSY-VKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSV 330
Cdd:cd17474 230 GISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFgARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLL 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446532703 331 MFVVVNACHQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYTTPATTFIVMGIVFAVSSLFLIC 394
Cdd:cd17474 310 TTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
5-393 |
9.38e-16 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 78.38 E-value: 9.38e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 5 SIWRSNFRILWLSQFIAIAGLTVLVPLLPIYMASLqNLSVVEIqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLR 84
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEF-GLSAAQL----GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 85 ALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAED-RGKVLGRLQSSVSAGSLVGPLIGGVTASI 163
Cdd:COG2223 76 GLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDrRGLALGLAAGGGNLGAAVAAFLAPLLIAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 164 LGFSALLMSIAVITFIVCIFGALKLIETTHMPKSQTPNINKGIRRSFQcllcTQQTCRFIIVGVLANFAMYGMLTALSPL 243
Cdd:COG2223 156 FGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALR----DPRFWLLSLLYFGTFGSFIGFSSWLPPY 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 244 ASSVNHtaiDDRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLAT-NIEFLMAARILQGLT 322
Cdd:COG2223 232 LVDQFG---LSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLA 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446532703 323 YSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYT-TPATTFIVMGIVFAVSSLFLI 393
Cdd:COG2223 309 LGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTL 380
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
12-393 |
2.59e-14 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 73.80 E-value: 2.59e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 12 RILWLSQFIAIAGLTVLVPLLPIYMASLQNLSVVEIqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAV 91
Cdd:cd17329 2 WVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIV----GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 92 CLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAED-RGKVLGRLQSSVSAGSLVGPLIGGVTASiLGFSALL 170
Cdd:cd17329 78 GFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPEnRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 171 MSIAVITFIVCIFGALKLIETThmpKSQTPNINKGIRRSFQCLLCTQQTCRFIIVGVLAnFAMYGMLTalSPLASSVNHT 250
Cdd:cd17329 157 LAAAVLFLLAALVLLFLLPETR---PKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLI-SLIYFQLE--STLPVYVVEI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 251 AIDDRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSV 330
Cdd:cd17329 231 LGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAV 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446532703 331 MFVVVNACHQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYTTPATTFIVMGIVFAVSSLFLI 393
Cdd:cd17329 311 QTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLL 373
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
49-393 |
3.42e-13 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 70.32 E-value: 3.42e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 49 LWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLF-GGVVDASSAFAS 127
Cdd:cd17316 36 LQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGiGGEYPGASTYVA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 128 AEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMsiavITFIVCIFGALKLIetthmpksqtpninkGIR 207
Cdd:cd17316 116 EFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWR----ILFLIGALPALLAL---------------LLR 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 208 RSFQCLlctqqtcrfIIVGVLANFAMYGMLTALSPLASSVNHTAIDDRSVIGFLQSAFWtasILSAPLWGRFNDKSYVKS 287
Cdd:cd17316 177 RRTLLL---------ILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGA---LVGALIAGLLSDRIGRKK 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 288 VYIFATIACGCSAIL--QGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVIGQIIGSLSG 365
Cdd:cd17316 245 TLVIGLILSGILALPlfYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLI 324
|
330 340
....*....|....*....|....*...
gi 446532703 366 AAITSYTTPATTFIVMGIVFAVSSLFLI 393
Cdd:cd17316 325 ALLLASTGGTGVPALILALLAIVALIVA 352
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
13-393 |
6.93e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 69.52 E-value: 6.93e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 13 ILWLSQFIAIAGLTVLVPLLPIYMASLQNLSvveiQLWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVC 92
Cdd:cd17473 3 TLLLASTLTVMAGAAIAPALPAIAQHFVPNS----ELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 93 LFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAED-RGKVLGRLQSSVSAGSLVGPLIGGVTASI---LGFSA 168
Cdd:cd17473 79 GVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEeRAKMLGLQSAAMSLGGVVFLLLGGALAEIgwrAPFLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 169 LLMSIAVItfivcIFGALKLIETthMPKSQTPNINKGIRRSFQCLLCTQQTCrfiIVGVLANFAMYGMLTALSPLassVN 248
Cdd:cd17473 159 YLLALPVL-----ILVLLFLPEP--ARKSKSAASPGAATAAALPWKRVLPIY---FLAFLAMLLFYVIPIQLPFL---LQ 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 249 HTAIDDRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQ 328
Cdd:cd17473 226 ERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLP 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446532703 329 SVMFVVVNACHQQLKGTFVGTTNSMLVIGQIIGSL-SGAAITSYTTPATTFIVMGIVFAVSSLFLI 393
Cdd:cd17473 306 TLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLvLGPLVNLTGGLSGAFLILGVLALVLAIVLL 371
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
222-393 |
3.07e-12 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 67.31 E-value: 3.07e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 222 FIIVGVLANFAMYGMLTALSPLASSVNHTAiddrSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAI 301
Cdd:COG2814 15 LALGAFLSGLGIGIVLPALPLIAADLGASP----AQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 302 LQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYTTPATTFIVM 381
Cdd:COG2814 91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVN 170
|
170
....*....|..
gi 446532703 382 GIVFAVSSLFLI 393
Cdd:COG2814 171 AVLALLALLLLL 182
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
13-191 |
4.62e-11 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 63.29 E-value: 4.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 13 ILWLSQFIAIAGLTVLVPLLPIYMASLqNLSVVEIQLwsgiAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVC 92
Cdd:COG0477 18 ALALGTFLEGLDFTIVNVALPSIAADL-GASSAQLGW----IVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 93 LFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASA-EAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLM 171
Cdd:COG0477 93 SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAeLFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFL 172
|
170 180
....*....|....*....|
gi 446532703 172 sIAVITFIVCIFGALKLIET 191
Cdd:COG0477 173 -INAPLGLLALVLRLRLPES 191
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
221-391 |
5.32e-11 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 63.74 E-value: 5.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 221 RFIIVGVLANFAMYGMLTALSPLASSVNHTAIDDRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSA 300
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 301 ILQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYTTPATTFIV 380
Cdd:COG2271 90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI 169
|
170
....*....|.
gi 446532703 381 MGIVFAVSSLF 391
Cdd:COG2271 170 LGLPGLLLALL 180
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-391 |
6.22e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 63.72 E-value: 6.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 1 MINQSIWRSNFRILWLsqFIAIAGLTVLVPLLPIYMASLQNLSVVEiqlwSGIAIAAPAVTTMIASPIWGKLGDKISRKW 80
Cdd:COG0738 1 MSKKNYRRALIAIYLL--FFLWGFATALWGPLIPALKDAFGLSDAQ----AGLLLFAFFLGYLLASLPAGRLIDRFGYKR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 81 MVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVT 160
Cdd:COG0738 75 GLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 161 ASI---LGFSALLMSIAVITFIVCIFGALKLIETTHMPKSQTPNINKGIRRSFQcllctqqtCRFIIVGVLANFAMYGML 237
Cdd:COG0738 155 ILLglsLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLK--------NPRLLLGGLAIFLYVGAE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 238 TALSPLASSVNHTAID-DRSVIGFLQSAFWTASILSAPLWGRFNDK-SYVKSVYIFATIACGCSAILqGLATNIEFLMAA 315
Cdd:COG0738 227 GAIGDWLPLYLKDVLGlSEATAALGLSLFWGGMTIGRFLGGFLLKRfGPVRLLRLSALLAAVGLLLA-LLAPGPWLALIG 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446532703 316 RILQGLTYSaLIQSVMFVVVNACHQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYTTPATTFIVMGIVFAVSSLF 391
Cdd:COG0738 306 LALVGLGLS-LMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLL 380
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
222-393 |
5.83e-10 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 60.51 E-value: 5.83e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 222 FIIVGVLANFAMYGMLTALSPLASSVNHTaidDRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAI 301
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGI---SPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 302 LQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYTTPATTFIVM 381
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157
|
170
....*....|..
gi 446532703 382 GIVFAVSSLFLI 393
Cdd:pfam07690 158 AILSLLAAVLLL 169
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
13-393 |
1.80e-09 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 59.19 E-value: 1.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 13 ILWLSQFIAIAGLTVLVPLLPIYMASLQnLSVVEIQLWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVC 92
Cdd:cd17388 3 FILVTVLLDAMGIGLIMPVLPTLLREFV-GDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 93 LFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASIlGFSALLMS 172
Cdd:cd17388 82 YLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEI-SPRAPFLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 173 IAVITFIVCIFGALKLIEtTHMPKSQTPNINKGIR--RSFQCLlctqqtcrFIIVGVLANFAMYGMLTALSPLASSVNHT 250
Cdd:cd17388 161 AAGLNGLNFLLGLFVLPE-SLPPERRRAFRWRRANpfGSLRWL--------TGFPGLLGLLAVFFLIQLIGQVPATTWVL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 251 AIDDR-----SVIGFLQSAFWTASILS-APLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARI---LQGL 321
Cdd:cd17388 232 FTEDRfdwspTMVGLSLAVFGLLHALFqAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILIllaLGGI 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446532703 322 TYSALiQSVMFVVVNACHQ-QLKGTFVGTTNsmlvIGQIIGSLSGAAITSYTT---PATTFIVMGIVFAVSSLFLI 393
Cdd:cd17388 312 AGPAL-QGLLSRQVPENEQgELQGVLTSLTS----LTSIIGPLLFTGIFAASPatwPGLAWIIGAALYLICLVLAY 382
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
19-397 |
2.98e-09 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 58.36 E-value: 2.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 19 FIAIAGLTVLVPLLPiYMASLQNLSVVEIQLwsgiAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMAL 98
Cdd:cd17320 9 ALGPLAIDMYLPALP-AIARDLGASASAVQL----TLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 99 CTTPLQFVLVRLLQGLFGGVVDASSAFASA-EAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVIT 177
Cdd:cd17320 84 ASSIEQLLIARFLQGLGAAAGSVVARAIVRdLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 178 FIVcIFGALKLIETTHMPKSQTPNInKGIRRSFQCLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASSVNHTaidDRSV 257
Cdd:cd17320 164 LLL-LLLVLLFLPETLPEEKRKPLL-SSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGL---SPAQ 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 258 IGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNA 337
Cdd:cd17320 239 FGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATS 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 338 CHQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYtTPATTFIVMGIVFAVSSLFLICSTI 397
Cdd:cd17320 319 LALEPFPHVAGTASALLGFLQFLIGALAGALVGL-LPNGTALPMGLLILVLGLLALLLLI 377
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
26-397 |
4.79e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 57.99 E-value: 4.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 26 TVLVPLLPIYMASLQNLSVVEIqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKW-----MVLRALLGLAVCLFLMALCT 100
Cdd:COG2211 27 GLLSAYLLYFYTDVLGLSAALV----GLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAP 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 101 TPLQ------FVLVRLLQGLFGGVVDA--SSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSA---- 168
Cdd:COG2211 103 DLSPtgkliyALVTYLLLGLAYTLVNIpySALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAalgy 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 169 -LLMSIAVITFIVCIFGALKLIETTHMPKSQTPNinkgIRRSFQCLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASSV 247
Cdd:COG2211 183 rLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVS----LKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYV 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 248 NHtaiDDRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLA--TNIEFLMAARILQGLTYsA 325
Cdd:COG2211 259 LG---LSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGL-G 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 326 LIQSVMFVVVNAC--------HQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYT--------TPATTFIVMGIVFAVSS 389
Cdd:COG2211 335 AILVLPWAMLADVvdydewktGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFgyvagaaqSPSALTGIRLLFFLLPA 414
|
....*...
gi 446532703 390 LFLICSTI 397
Cdd:COG2211 415 VLLLLAAL 422
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
14-395 |
5.67e-09 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 57.24 E-value: 5.67e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 14 LWLSQFIAIAGLTVLVPLLPIYMASLQNLSVVeiqlwSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCL 93
Cdd:cd17390 1 LYLVGFLDLFGVSMILPLLSTHIRSLGASPTV-----IGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGY 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 94 FLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGG-VTASILGFsallms 172
Cdd:cd17390 76 VLLGFSTSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGhLAETDGGF------ 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 173 iavitFIVCIFGALKLIetthmpksqtpnINKGIrrsfqcllctqqtcRFIIVGVLANFAMYGMLTALSPLASSVNHTAI 252
Cdd:cd17390 150 -----YYVALLCSAIFI------------LNAGL--------------VWFLLSKLWDLLLVRFLMGFSVLLFRSNFSLY 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 253 ------DDRSVIGFLQSAFWTASILSAPLWGR---FNDKSYVKSVYIFATIACgCSAILQGLATNIEFLMAARILQGLTY 323
Cdd:cd17390 199 leerfdLSPKTIGYLISYSGVLGALSGFLVGRilkLYKNNEYLLLLHSFILLA-LSLLGLALAPSIWLLVLCLTPLSISS 277
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446532703 324 SALIQSVMFVVVNACHQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYTTPATTFIVMGIVFAVSSLFLICS 395
Cdd:cd17390 278 AVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQEFSVSGPGLLGAVLALAAILLMLARQ 349
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
29-393 |
1.71e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 56.01 E-value: 1.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 29 VPLLPIYMASLqNLSVVEIQLWSGIAIAAPAVTTMIAspiwGKLGDKISRKWMVlrALLGLAVCLF---LMALCTTPLQF 105
Cdd:cd17370 19 RSILPLFLVVL-GASAAAVGLIEGLAEALGSLLRLFS----GYLSDRTGKRKPL--VILGYGLSALakpLLALAGSWQLV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 106 VLVRLL----QGLFGGVVDASSAFASAEApaeDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFS-----ALLMSIAVI 176
Cdd:cd17370 92 LLLRILerlgKGIRTPPRDALLADATPPS---GRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGNyrtifLLAAIPALL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 177 TFIVCIFGALKLIETTHMPKSQTPNINKGIRRSFQcllctqqtcRFIIVGVLANFAMYGMltALSPLASSVNHTAIddrS 256
Cdd:cd17370 169 ALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFW---------LYLLAVALFALGNFSF--AFLILRAQELGLSA---A 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 257 VIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLtYSALIQSVM-FVVV 335
Cdd:cd17370 235 LIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGL-YMGAQESIErAAVA 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 446532703 336 NACHQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYTTPATTFIVMGIVFAVSSLFLI 393
Cdd:cd17370 314 DLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
14-188 |
2.08e-08 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 55.70 E-value: 2.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 14 LWLSQFIAIAGLTVLVPLLPIYMASLQNlSVVEIQLWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCL 93
Cdd:PRK09874 224 LFVTTLIIQVATGSIAPILTLYVRELAG-NVSNIAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLL 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 94 FLMALCTTPLQFVLVRLLQGLF-GGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMS 172
Cdd:PRK09874 303 IPMSFVQTPLQLGILRFLLGAAdGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLV 382
|
170
....*....|....*.
gi 446532703 173 IAVITFIVCIFGALKL 188
Cdd:PRK09874 383 TAGVVLFNAVYSWNSL 398
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
14-393 |
4.70e-08 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 54.49 E-value: 4.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 14 LWLSQFIAIAGLTVLVPLLPIYMASLQNLSVVeiqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCL 93
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFGGLSLV------SWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 94 FLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAED-RGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSAllms 172
Cdd:cd17502 75 LLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPReRGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRW---- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 173 iavITFIVCIFGALKLIetthmpksqtpninkgIRRSFQCLLctqqtcrfiIVGVLANFAMYGMLTALSPLASSV-NHTA 251
Cdd:cd17502 151 ---CFYINLPIGGLALA----------------LLRTILLSS---------IFGFLFGGALFGLIYYLPLYFQLVlGDSA 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 252 IDDrsviGFLQSAFWTASILSAPLWGRFNDKS-YVKSVYIFATIACGCSAIL---QGLATNIEFLMAARILQGLTYSALI 327
Cdd:cd17502 203 TKS----GVRLLPLIIGLVIGSIISGALISKTgRYKPLIVIGTILMSVGAGLlttLTLDTSKWLLIGYLILLGLGLGIGF 278
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446532703 328 QSVMFVVVNAchqqLKGTFVGTTNSMLVIGQIIGSLSGAAITsyttpaTTFIVMGIVFAVSSLFLI 393
Cdd:cd17502 279 QQPLVAVQNA----VPPADVGVATATNTFFRSLGGTLGVAIT------DVFLVALALAALAFLLSL 334
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
6-119 |
4.87e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 54.59 E-value: 4.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 6 IWRSNFRILWLSQFIAIAGLTVLVPLLPIYMASLQNLSVVEIqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRA 85
Cdd:COG2814 204 LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAA----GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIG 279
|
90 100 110
....*....|....*....|....*....|....
gi 446532703 86 LLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVV 119
Cdd:COG2814 280 LLLLALGLLLLALAGSLWLLLLALFLLGFGFGLL 313
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
16-370 |
1.60e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 52.95 E-value: 1.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 16 LSQFIAIAGLTVLVPLLPIYMASLqNLSVVEIQlwsgIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFL 95
Cdd:cd17321 3 LAVFLAALDVTIVNVALPTIARDL-GASPSQLQ----WVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 96 MALCTTPLQFVLVRLLQGLFGG-VVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIA 174
Cdd:cd17321 78 CALAPSLAFLIAARALQGIGAAaIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 175 VITFIVcifgalklietthmpksqtpninkgirrsfqcLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASSVNHtaiDD 254
Cdd:cd17321 158 PIGLVA--------------------------------LLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLG---YS 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 255 RSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQ---GLATNIEFLMAARILQGLTYSALIQSVM 331
Cdd:cd17321 203 PLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLallGADSSVWLLLPGLVLLGLGLGLFATPLT 282
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 446532703 332 FVVVNACHQQLKGTFVGTTNSMLVIGQIIG-SLSGAAITS 370
Cdd:cd17321 283 NAALSSVPKEKAGAASGILNTARQLGGALGvALLGALLTA 322
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
221-393 |
2.43e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 52.12 E-value: 2.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 221 RFIIVGVLANFAMYGMLTALSPLASSVNHTAIDDRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSA 300
Cdd:COG0477 14 RALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLAS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 301 ILQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYTTPATTFIV 380
Cdd:COG0477 94 LLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLI 173
|
170
....*....|...
gi 446532703 381 MGIVFAVSSLFLI 393
Cdd:COG0477 174 NAPLGLLALVLRL 186
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
27-393 |
2.95e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 52.17 E-value: 2.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 27 VLVPLLPIYMASLqNLSVVEIqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFV 106
Cdd:cd17478 14 FLPALLPLLIAKL-GLSYAQA----GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 107 LVRLLQGLFGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSA--LLMSIAVITFIVCIFG 184
Cdd:cd17478 89 LLVALAGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGllILLIIPGLAVALLLLR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 185 ALKLIETTHMPKSQTPNINKGIRRSFQCLLctqqtcRFIIVGVLANFAMYGMLTALSPLASSVNHTAIddrsVIGFLQSA 264
Cdd:cd17478 169 LRPLKKPEAKKAAAKSSARSTLKGVWRALL------LLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLV----FAGLLLSL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 265 FWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALiqSVMFVVVnachQQLKG 344
Cdd:cd17478 239 FLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASF--PVTVVLA----QELLP 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 446532703 345 TFVGTTNSM-----LVIGQIIGSLSGaAITSYTTPATTFIVMGIVFAVSSLFLI 393
Cdd:cd17478 313 GNVGLASGLmmglsFGLGGIGAPVLG-ALADAFGLESVLLILALLPLLGALLAF 365
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
10-191 |
3.31e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.79 E-value: 3.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 10 NFRILWLSQFIAIAGLTVLVPLLPIYMASLQNLSVVEiqlwSGIAIAAPAVTTMIASPIWGKLGDKISR--KWMVLRALL 87
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQ----AGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 88 GLAVCLFLMALCTTPLQFVLVRLLQGLF-GGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGF 166
Cdd:COG2271 257 LAALALLLLALLPSPALAIALLFLAGFGlGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGY 336
|
170 180
....*....|....*....|....*
gi 446532703 167 SALLMSIAVITFIVCIFGALKLIET 191
Cdd:COG2271 337 QAAFLLLAALALLAALLALLLLRET 361
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
222-393 |
3.53e-07 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 52.04 E-value: 3.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 222 FIIVGVLANFAMYGMLTALSPLASSVNHTAiddrSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAI 301
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSA----SQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 302 LQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYTTPA--TTFI 379
Cdd:cd06174 77 LFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwrAVFL 156
|
170
....*....|....
gi 446532703 380 VMGIVFAVSSLFLI 393
Cdd:cd06174 157 IAAALALLAAILLL 170
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
64-392 |
3.67e-07 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 51.80 E-value: 3.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 64 IASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLF-GGVVDASSAFASAEAPAEDRGKVLGRL 142
Cdd:cd17319 53 LFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAeAGFFPGAIKALAEWFPARERGRATGLF 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 143 QSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIFGALKLietthmpksqtpninkgirrsfqcllctQQTCRF 222
Cdd:cd17319 133 NSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYL----------------------------RQVWGL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 223 IIVGVLANFAMYGMLTALSPLassVNHTAIDDRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAIL 302
Cdd:cd17319 185 ALGYFGINYALYGLLTWLPTY---LKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 303 QGLATNIEFLMAARILQGLTYSAL--IQSVMFVVVN-ACHQQLKGTFVGTTNSMLVIGQIIGSLS-GAAIT---SYTTPA 375
Cdd:cd17319 262 LLLAYLTTSPVVAVILLSLAGFGIgaASPVFWSLPAdLLPGEAAATAGGLINSGGNLGGFVAPLLiGYLVDatgSYTAAF 341
|
330
....*....|....*..
gi 446532703 376 TTFIVMGIVFAVSSLFL 392
Cdd:cd17319 342 LFLAAVALLAALLVLLL 358
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
26-392 |
5.76e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 51.04 E-value: 5.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 26 TVLVPLLPIYMASLQNLSVveiqlWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQF 105
Cdd:cd17504 13 TMLSPALPTIQREFGTSAA-----AVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 106 VLVRLLQGLFGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIfgA 185
Cdd:cd17504 88 IAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAA--L 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 186 LKLIETTHMPKSQTPNINkgirrsfqcllctqqtcrfiIVGVLANFAMYGMLTALS-PLASSVNHTAIDDRSVIGFLQSA 264
Cdd:cd17504 166 VPLIDLRLLRRRNVLLAN--------------------ITALLAGFGMFMVFQLLPqLLQLPTPTGFGLGITEAGLLLLP 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 265 FWTASILSAPLWGRFNDK-SYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLK 343
Cdd:cd17504 226 GALVMLIAGPLAGRLIARvGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRT 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446532703 344 GTFVGTTNSMLVIGQIIGS-LSGAAITSYTTPATTF-----------IVMGIVFAVSSLFL 392
Cdd:cd17504 306 GIATGMNTVLRTIGSAIGPaIAGAILTTYTVSITSGgvptegayvlaFLIGAALALAALLL 366
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
11-190 |
7.33e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 51.03 E-value: 7.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 11 FRILWLSQFIAIAGLTVLVPLLPIYMASLQNLSVVEIqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLA 90
Cdd:COG2223 207 FWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATA----GLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMA 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 91 VCLFLMALCTTPLQ--FVLVRLLQGLFGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSA 168
Cdd:COG2223 283 LGLLLLALALGSLWlfLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYT 362
|
170 180
....*....|....*....|..
gi 446532703 169 LLMSIAVITFIVCIFGALKLIE 190
Cdd:COG2223 363 AAFLVFAVLALVALVLTLLLYR 384
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
258-398 |
8.39e-07 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 50.64 E-value: 8.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 258 IGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMFVVVNA 337
Cdd:cd17502 32 VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADL 111
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446532703 338 CHQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYTTPATTF----IVMGIVFAVSSLFLICSTIT 398
Cdd:cd17502 112 VPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFyinlPIGGLALALLRTILLSSIFG 176
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
19-181 |
8.44e-07 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 50.65 E-value: 8.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 19 FIAIAGLTVLVPLLPIYMasLQNLSVVEIQLwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMAL 98
Cdd:cd17384 204 CFSNSGIAILEPCLPIWM--METMCPPKWQL--GTAFLPDSIGYLIGTNLFGPLAHKIGRWLCSLLGMLLVGISLILIPL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 99 CTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAEDRGKVLGRL----QSSVSAGSLVGPLIGGVTASILGFSALLMSIA 174
Cdd:cd17384 280 AKNIYGLIIPHFGLGLGIGMVDSSMMPLLAYLVDLRHSSVYGSVyaiaDVAFCLAFALGPSLGGAIVKSIGFPWLMRIIG 359
|
....*..
gi 446532703 175 VITFIVC 181
Cdd:cd17384 360 IINILYA 366
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
52-188 |
1.06e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 50.29 E-value: 1.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 52 GIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGL-FGGVVDASSAFASAEA 130
Cdd:cd17489 230 GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLgFGLLFPALQALAVDLV 309
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 446532703 131 PAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIFGALKL 188
Cdd:cd17489 310 PPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
14-392 |
1.39e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 50.26 E-value: 1.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 14 LWLSQFIAIAGLTVLVPLLPIYMASLqNLSVVEIqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCL 93
Cdd:COG2807 23 IVLVALNLRPAITSVGPLLPEIRADL-GLSATQA----GLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 94 FLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSI 173
Cdd:COG2807 98 LLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVW 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 174 AVITFIVCIFGALKLIETTHMPKSQTPninkgiRRSFQCLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASSVNHTAid 253
Cdd:COG2807 178 ALLALLALLLWLPLLRRRPAAAAAAPA------AASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSA-- 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 254 drSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALI-QSVMF 332
Cdd:COG2807 250 --ATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFpLALTL 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446532703 333 VVVNACHQQLKGTFVGTTNSMLVIGQIIGSLSGAAI----TSYTTPATTFIVMGIVFAVSSLFL 392
Cdd:COG2807 328 IGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALhdatGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
52-394 |
1.43e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 49.85 E-value: 1.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 52 GIAIAAPAVTTMIASPIWGKLGDK-ISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEA 130
Cdd:cd17471 35 GIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVVLLSLGAAAFPQLFALAREY 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 131 PAEDRGK----VLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVItFIVCIFGALKLIETTHMPKSQTPNINKGI 206
Cdd:cd17471 115 ADRSSGRdatlFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALL-YLVVALLVLFLLPSVKPPAQKATPASSLV 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 207 RRSFQcllctQQTCRFIIVGVLANFAMYGMLTALSPLASSVNHTAIDDrsvIGFLqsaFWTASILSAP---LWGRFNDKS 283
Cdd:cd17471 194 KAPVN-----RRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESW---VGLL---FGLAAALEIPimlLAGLLAKRF 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 284 YVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMFVVvnachQQLKGTFVGTT----NSMLVIGQI 359
Cdd:cd17471 263 GKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYF-----QDLMPGQPGLAttlySNASRIGSL 337
|
330 340 350
....*....|....*....|....*....|....*
gi 446532703 360 IGSLSGAAITSYTTPATTFIVMgIVFAVSSLFLIC 394
Cdd:cd17471 338 LGGLLAGVIAQYFGYRAVFLVC-AVLALLALVLLL 371
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
24-393 |
1.90e-06 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 49.53 E-value: 1.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 24 GLTVLVPLLPIYMASLQ-NLSVVeiqlwsGIAIAAPAVTTMIASPIWGKLGDKI-SRKWMVLRALLGLAVCLFLMALCTT 101
Cdd:cd17490 11 SQYVYVPFLSPYAESLGaSLSMI------GIILGAYGISQMLLRIPLGILSDRIgKRKLFIIIGLLFTVLASLIMILFPS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 102 PLQFVLVRLLQGLFGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSAL-LMSI--AVITF 178
Cdd:cd17490 85 PWGLLIARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPfLLAAlaGVLGF 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 179 IVCIFgalklIETTHMPKSQTPNINKGIRRsfqclLCTQQTCRFI-IVGVLANFAMYGMLTALSPL-ASSVNHTAIDdrs 256
Cdd:cd17490 165 ILSLF-----IKEERREKKPVLTELKELLS-----VLKDKKLLFFsLLAILQQMITFSTTFGFTPLiAKQLGASSFQ--- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 257 vIGFLQSAFWTASILSAPLWGRFNDKSY-VKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMFVVV 335
Cdd:cd17490 232 -LGLLSIIYLLPNALASLLSGTLFYKKLgERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSI 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 446532703 336 NACHQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYTTPATTFIVMGIVFAVSSLFLI 393
Cdd:cd17490 311 EGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSL 368
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
10-119 |
2.96e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 49.11 E-value: 2.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 10 NFRILWLSQFIAIAGLTVLVPLLPIYMASLQNLSVveiqLWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGL 89
Cdd:cd17503 179 NFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSA----FESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLL 254
|
90 100 110
....*....|....*....|....*....|...
gi 446532703 90 AVCLFLMALC---TTPLQFVLVRLLQGLFGGVV 119
Cdd:cd17503 255 ALGTLLLAFLtpdTSLWLIILPLFIRGLGMGLV 287
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
19-180 |
3.78e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 48.72 E-value: 3.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 19 FIAIAGLTVLVPLLPIYMASLQNLSvveiQLWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMAL 98
Cdd:cd17473 207 FLAMLLFYVIPIQLPFLLQERGGGS----AALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLAL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 99 CTTPLQFVLVRLLQGL-FGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLI--------GGVTASILGFSAL 169
Cdd:cd17473 283 ASGLWVVLLGAILAGLgFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVlgplvnltGGLSGAFLILGVL 362
|
170
....*....|.
gi 446532703 170 LMSIAVITFIV 180
Cdd:cd17473 363 ALVLAIVLLLL 373
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
221-397 |
9.68e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 47.54 E-value: 9.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 221 RFIIVGVLANFAMYGMLTAL-SPLASSVNHTAIDDRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCS 299
Cdd:COG0738 7 RRALIAIYLLFFLWGFATALwGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 300 AILQGLATNIEFLMAARILQGLTySALIQSVMFVVVNACHQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYTTPATT-- 377
Cdd:COG0738 87 LLLFALAPSYPLLLLALFLLGLG-LGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWhl 165
|
170 180
....*....|....*....|.
gi 446532703 378 -FIVMGIVFAVSSLFLICSTI 397
Cdd:COG0738 166 pYLILAVLLLLLALLFLRSKL 186
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
13-385 |
1.05e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 47.32 E-value: 1.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 13 ILWLSQFIAIAGLTVLVPLLP-IYMASLQNLSVVEIQLWSGIaiaapavttMIASPIWGKLGDKISRKWMVLRALLGLAV 91
Cdd:cd17333 3 ISFFSNGLTDALLGILGPSLEeAFNLNVADVSVIFSSQNAGY---------LIGSLLAGFLMKRLGRRRTLILGLLLISL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 92 CLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGV-TASILGFSALL 170
Cdd:cd17333 74 ALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSlLTSELSWSWAY 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 171 MSIAVITFIVCIFGALklietTHMPKSQTPNINKGIRRSFQCLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASSVNHT 250
Cdd:cd17333 154 LIIGLIYLLLAILILL-----TLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 251 AID-DRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKsVYIFATIACGCSAILQGL-ATNIEFLMAARILQGLTYSAL-- 326
Cdd:cd17333 229 KKHvSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPH-TLLVLSGSGALLGLLILLlAPTLVVGLVATALLGLFMAALfp 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 327 -IQSVMFVVVNACHQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYTTPATTFIVMGIVF 385
Cdd:cd17333 308 tILSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIF 367
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
7-179 |
1.07e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 47.15 E-value: 1.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 7 WRSNFRILWLsqFIAIAGLTVL----VPLLpIYMASLQNLSVVeiqlWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMV 82
Cdd:cd17370 195 LKKLPKAFWL--YLLAVALFALgnfsFAFL-ILRAQELGLSAA----LIPLLYALFNLVYALAAYPAGRLSDRIGRKKLL 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 83 LRALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAED-RGKVLGRLQSSVSAGSLVGPLIGGVTA 161
Cdd:cd17370 268 ILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAElRGTAYGLFNTVVGIGWLLASLIAGYLW 347
|
170 180
....*....|....*....|....
gi 446532703 162 SILG------FSALLMSIAVITFI 179
Cdd:cd17370 348 DLISpsaaflFSAVLALIALLLLL 371
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
10-102 |
1.07e-05 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 47.37 E-value: 1.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 10 NFRILWLSQFIAIAGLTVLVPLLPIYMASLQNLSVveiqLWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGL 89
Cdd:TIGR00711 256 NFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTA----LQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIGLILY 331
|
90
....*....|...
gi 446532703 90 AVCLFLMALCTTP 102
Cdd:TIGR00711 332 AVGFYWRAFTFTP 344
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
256-394 |
1.64e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 46.42 E-value: 1.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 256 SVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALiqSVMFVVV 335
Cdd:cd17330 34 YYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNV--SVAQAYI 111
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 336 NACHQQLKGTFV-GTTNSMLVIGQIIGSLSGAAITSYTTPATTFIVMGIVFAVSSLFLIC 394
Cdd:cd17330 112 ADITDEEERAKAfGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLF 171
|
|
| 2A0121 |
TIGR00900 |
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds] |
11-361 |
1.83e-05 |
|
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 46.54 E-value: 1.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 11 FRILWLSQFIAIAGLTVLVPLLPIYMASLQNLSVVeiqlwSGIAIAAPAVTTMIASPIWGKLGDKISRKWM-----VLRA 85
Cdd:TIGR00900 1 FRLLFAAQLISLIGTAITQVALPLYVLAGTGSASV-----LSLAALAGMLPYVVLSPIAGALADRYDRKKVmigadLIRA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 86 LLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAEDR-GKVLGRLQSSVSAGSLVGPLIGGVTASIL 164
Cdd:TIGR00900 76 VLVAVLPFVALLGGLNIWQVYVLAGILAIAQAFFTPAYQAMLPDLVPEEQlTQANSLSQAVRSLFYIVGPGIGGLMYATL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 165 GFSAlLMSIAVITFivciFGALKLIETTHMPKSQ-------TPNINKGIRRSFQCLLCTQQTCRFIIVGVLANFAMYGML 237
Cdd:TIGR00900 156 GIKW-AIWVDAVGF----AISALLIVSVRIPELAaseiqalSNAVLRDTREGIKFVLKNPLLRTLLLLALLFNLVFAPAI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 238 TALSPLASS--VNHTAIDdrsvIGFLQSAFWTASILSA---PLWGRFNDKSY-VKSVYIFATIACGCSAILQGlatNIEF 311
Cdd:TIGR00900 231 VALFPYVQSkyLGRGSTH----YGWVLAAFGLGALLGAlllGLLGRYFKRMAlMTGAIFVIGLAILVVGLTPP---NFPL 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 446532703 312 LMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVIGQIIG 361
Cdd:TIGR00900 304 FLVLWFAIGVGYGPINVPQGTLLQRRVPAELLGRVFGAQFSLSHAAWPLG 353
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
16-392 |
2.06e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 46.40 E-value: 2.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 16 LSQFIAIAGLTVLVPLLPIYMASlQNLSvveiQLWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFL 95
Cdd:cd17477 3 LSVALLGLGSGLLLPLLSLRLER-EGVS----TALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 96 MALCTTPLQFVLVRLLQGLFGGVVDASS-AFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVtASILGFSALLMSiA 174
Cdd:cd17477 78 LALTDSPWVWFLLRFVMGIGLAGLFVVSeSWLNALATNENRGRVLGLYSTVLGLGFALGPLLLAL-VGTAGALPFLIA-A 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 175 VITFIVCIFGALKLIETTHMPKSQTPNINKGIRRSfqcllctqqtcRFIIVGVLANFAMYGMLTALSPL-ASSVNHTAid 253
Cdd:cd17477 156 VLLLLALVPLLLTRRAAPEIEEAESISLRRLLRIA-----------PLALLGAFVAGFLEGAFYSLLPLyGLRLGLSV-- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 254 drSVIGFLQSAFWTASILSAPLWGRFNDK-SYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGltysALIQSVMF 332
Cdd:cd17477 223 --AQAALLLAAFVLGGLLLQWPLGWLADRfDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWG----GAAGPLYT 296
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446532703 333 VVVNACHQQLKGTFVGTTNSMLV----IGQIIGSLSGAAITSYTTPATTFIVMGIVFAVSSLFL 392
Cdd:cd17477 297 LALALAGDRLPGDELVAANAALLllygLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
231-392 |
2.77e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 46.03 E-value: 2.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 231 FAMYGMLTALSPLASSVNHTAIDD--------RSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAIL 302
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQiaedfhvsEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 303 QGLATNIEFLMAARILQGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYTTPATTF---- 378
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFwfla 160
|
170
....*....|....
gi 446532703 379 IVMGIVFAVSSLFL 392
Cdd:cd17323 161 IISGFCLILIFLFL 174
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
50-392 |
2.97e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 45.72 E-value: 2.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 50 WSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLF--GGVVDASSAFAS 127
Cdd:cd17355 39 VISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGgaGTLAAVAFATVA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 128 AEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGF-SALLMSIAVITFIVCIFGALKLIET-THMPKSQTPNINKG 205
Cdd:cd17355 119 AWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWrTALLVLALLALLVLVPVLLLLRRRPaDLALRAYDDASPAS 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 206 IRRSFQCLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASSVNHTAIDDRSVIGFLQSAFWTASILSAPLWGRFnDKSYV 285
Cdd:cd17355 199 PGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRY-SPRRL 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 286 KSVYIFATiACGCSAILQGLATNIEFLMAArILQGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVIGQIIGSLSG 365
Cdd:cd17355 278 LAASYALR-ALGLALLLLLPFPPLALLLFA-ALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLG 355
|
330 340 350
....*....|....*....|....*....|.
gi 446532703 366 AAIT----SYTTPATTFIVMGIVFAVSSLFL 392
Cdd:cd17355 356 GLLYdrtgSYTAAWALAVALGLIAALLVLPI 386
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
11-189 |
3.24e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.05 E-value: 3.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 11 FRILWLSQFIAIAGLTVLVPLLPIYMASLQNLSvveiQLWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLA 90
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLYYFKYVLGLS----AALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAA 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 91 VCLFLMALC--TTPLQFVLVRLLQGLFGGVVDASSA--------FASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVT 160
Cdd:COG2211 306 LGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWamladvvdYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLL 385
|
170 180 190
....*....|....*....|....*....|....*..
gi 446532703 161 ASILGF--------SALLMSIAVITFIVCIFGALKLI 189
Cdd:COG2211 386 LALFGYvagaaqspSALTGIRLLFFLLPAVLLLLAAL 422
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
19-235 |
3.98e-05 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 45.33 E-value: 3.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 19 FIAIAGLTVLVPLLPIYMAslqNLSVVEIQLwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMAL 98
Cdd:cd17393 9 FINGILMASWATRIPAIKD---RLGLSDAAL--GLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 99 CTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASiLGFSA---LLMSIAV 175
Cdd:cd17393 84 APSVPALALALFLFGAANGALDVAMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLGAAAIG-AGVSPgvhLLAAAVL 162
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 176 ITFIVCIFGALKLIETTHMPKSQTPNINKGIRRSFQCLLctqqtcrfIIVGVLANFAMYG 235
Cdd:cd17393 163 LLLAALVAIRALLPGTGEAAEDRPDGAGKPGFLLPNRLL--------LLLGLLALAAALA 214
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
11-183 |
6.28e-05 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 44.96 E-value: 6.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 11 FRILWLSQFIAIAGLTVLVPLLPIYMAS--------LQNLSVVEIQlWSGIAIAAPA------------------VTTMI 64
Cdd:cd17389 1 ITIVFLALLLDLLAFTIILPLFPSLLDYygqnddsgLYSLQISSVD-WFRDAIGAPDerrynsvlfggligslfsLLQFL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 65 ASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAEDRGKVLGRLQS 144
Cdd:cd17389 80 SSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGV 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 446532703 145 SVSAGSLVGPLIGGVTASILGFS-----------ALLMSIAVITFIVCIF 183
Cdd:cd17389 160 AFSLGFIIGPMIGAYFASFTRSLgevffsmpalfALVLALADLLFIFFFL 209
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
59-393 |
6.83e-05 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 44.90 E-value: 6.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 59 AVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLlQGLFGGVVDASSAFASAEAPAEDRGKV 138
Cdd:cd17331 45 SVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRL-PSVFMHAMQAAQMVVTDLTDPGERAAA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 139 LGRLQSSVSAGSLVGPLIGGVTASILG-----FSALLMSIAVITFIVCIFGALKLIETTHMPKSQTPNINKGIRRSFQCL 213
Cdd:cd17331 124 LGRLGLSYGIGMVVGSFLGGLLTKKFGeqaaaLVAAVGSLLSIVLVILLIPSNTKSKREKEAKESASPPSVFNLKEILRL 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 214 LCTQQTCRFIIVGVLANFAMyGMLTALSPLAssvnhtAID----DRSVIGFLQSAFWTASILS-----APLWGRFNDKSY 284
Cdd:cd17331 204 LRLPGVAFLLLVKLLSGLPI-GMFQSMFSLV------AMDffglTPEENGYLMSYAGVLGMVVqgllvGPLTKRFGERSL 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 285 VK-SVYIFA---TIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVmfvvvnacHQQLKGTFVGTTNSMLVIGQII 360
Cdd:cd17331 277 LKlSVALLAigyLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAV--------PPEDTGTALGLSHALFSLVRTV 348
|
330 340 350
....*....|....*....|....*....|....
gi 446532703 361 GSLSGAAI-TSYTTPATTFIVMGIVFAVSSLFLI 393
Cdd:cd17331 349 SPTIGGALlQAYGFPSFGLLGAAINGLLTVYLLL 382
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
6-186 |
7.15e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.51 E-value: 7.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 6 IWRSNFRILWLSQFIAIAGLTVLVPLLPIYMASLQNLSVVEIQLWSGIAiaapAVTTMIASPIWGKLGDKISRKWMVLRA 85
Cdd:cd17316 174 LLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLI----SLGALVGALIAGLLSDRIGRKKTLVIG 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 86 LLGLAVCLFLMALCTT---PLQFVLVRLLQGLFGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTAS 162
Cdd:cd17316 250 LILSGILALPLFYLLSgspTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLA 329
|
170 180
....*....|....*....|....
gi 446532703 163 ILGFSALLMSIAVITFIVCIFGAL 186
Cdd:cd17316 330 STGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
50-393 |
1.05e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 44.22 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 50 WSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGL-FGGVVDASSAFASA 128
Cdd:cd17371 35 EAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLgFGGEWAAGAALMAE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 129 EAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSA---LLMSIAVITFIVCIFGALKLIETTHMPKSQTPNINKG 205
Cdd:cd17371 115 YVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIawrVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFA 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 206 iRRSFQCLLCTQQTCRFIIVGVL----ANFAMYGMLTALSPLASSVNHtaIDDRSVIGFLqSAFWTASILSAPLWGRFND 281
Cdd:cd17371 195 -DRPSLRELFSPPLLRTTLLASLlatgALGGYYGITTWLPSYLTGERG--LSFEGSAGYL-VVTILGGFLGYLAGGFLAD 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 282 KSYVKSVYIFATIACGCS--AILQGLATNIEFLMAARILqGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVIGQI 359
Cdd:cd17371 271 RIGRRNNFALFALGSAISilLYFFLPLSPTLILILGFPL-GFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGA 349
|
330 340 350
....*....|....*....|....*....|....
gi 446532703 360 IGSLSGAAITSYTTPATTFIVMGIVFAVSSLFLI 393
Cdd:cd17371 350 LFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLA 383
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
19-115 |
1.05e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 44.11 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 19 FIAIAGLTVLVPLLPIYMASLQnLSVVEIqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVcLFLMAL 98
Cdd:cd17335 7 FFFFAALGSLLPFLSVYLKQLG-LSPTQI----GILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAV-LFFLSL 80
|
90
....*....|....*..
gi 446532703 99 CTTPLQFVLVRLLQGLF 115
Cdd:cd17335 81 FFVAQIFWLLLLLVILG 97
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
8-119 |
1.35e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 43.99 E-value: 1.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 8 RSNFRILWLSQFIAIAGLTVLVPLLPIYMASLQNLSVVEIqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALL 87
Cdd:COG2270 237 YRDLLRFLLAYFFYRDGVQTVIAFAGIYAAGVLGFSTTEL----IVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLV 312
|
90 100 110
....*....|....*....|....*....|..
gi 446532703 88 GLAVCLFLMALCTTPLQFVLVRLLQGLFGGVV 119
Cdd:COG2270 313 IWIVVCLAAYFLTTALAFWILGLLIGLVMGGI 344
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
19-397 |
1.69e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 43.33 E-value: 1.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 19 FIAIAGLTVLVPLLPIYMASLqNLSVVEIQLwsgiAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMAL 98
Cdd:cd17503 6 FMAILDTTIVNVALPTIMGDL-GASLDTVQW----VITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 99 CTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAED-RGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVIT 177
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEkRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 178 FIVCIFGALklietthmpksqtpnINKGIRRSFQCLLctqqtcrFIIVGVLANFAMYGMLTALSPLASSVNHTaidDRSV 257
Cdd:cd17503 161 ILALLLAPL---------------LDLRLFKDRNFTL-------GLLLSFLLGLGLFGAMFLLPLYLQNVLGY---SAFE 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 258 IGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLA---TNIEFLMAARILQGLTYSALIQSVMFVV 334
Cdd:cd17503 216 SGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLtpdTSLWLIILPLFIRGLGMGLVFMPLNTLA 295
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446532703 335 VNACHQQLKGTFVGTTNSMLVIGQIIG-SLSGAAITSYTT---------------PATTFIVMGIVFAVSSLFLICSTI 397
Cdd:cd17503 296 LNSLPPEQIGDATALFNTIRQLGGSIGtALLATLLTNRTQfhhsrlsellaqqvqKQALIIAFNDAFLVSAILLLVGLL 374
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
14-302 |
2.30e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 43.00 E-value: 2.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 14 LWLSQ---FIAIAGLTVLVPLlpiyMASLQNLSVVEIqlwsGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLA 90
Cdd:cd17475 1 ATLAQaaaSLVAQGIPALAPF----LQEDLHLSLAQV----GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMG 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 91 VCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAE-APAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSAL 169
Cdd:cd17475 73 AAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRwFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 170 LMSIAVITFI--VCIFGALKLIETTHMPKSQTPNINKGIRRsfqcLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASSV 247
Cdd:cd17475 153 FVVAGLVSILaaVLFWLFYREPPAASAATESASTLLRSLKE----VLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDH 228
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 446532703 248 NHTAIddrSVIGFLQSAFWTASILSAPLWGRFNDKSYV---KSVYIFATIACGCSAIL 302
Cdd:cd17475 229 LGLSV---VAAGALLAVAQLGGALGRIGLGRVSDRVFGgrrRPVLVITAAIAAAALLV 283
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
24-392 |
4.53e-04 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 42.20 E-value: 4.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 24 GLTVLVPLLPIYMASLQNLSvveiQLWSGIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPL 103
Cdd:cd17472 11 GMFLVLPVLSVYAKSLPGAT----PTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIY 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 104 QFVLVRLLQGLfGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIF 183
Cdd:cd17472 87 GLILGRALQGS-GAISSVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 184 GALKLIettHMPKSqtPNINKGIRRSFQCLLCTQQTCRFIIVGVLANFAMYGMLTALSPLASSVNHTAIDdrsVIGFLQS 263
Cdd:cd17472 166 LLFFVP---DPPKI--VQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQ---LWKVYLP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 264 AFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLA-TNIEFLMAARILQGL---TYSALIQSVMFVVVNAch 339
Cdd:cd17472 238 AILIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFAaTSLWLLIIGLIIFFIgfnLLEALLPSLVSKIAPK-- 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 446532703 340 qQLKGTFVGTTNSMLVIGQIIGSLSGAAI---TSYTTPATTFIVMGIVFAVSSLFL 392
Cdd:cd17472 316 -EYRGTAMGIYNTSQFLGSFLGGALGGLLwglLGYSSVFLTILILALLWLLVSFLL 370
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
254-393 |
5.22e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 41.96 E-value: 5.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 254 DRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARILQGLTYSALIQSVMFV 333
Cdd:TIGR00895 50 DPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNAL 129
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446532703 334 VVNACHQQLKGTFVGTtnsmLVIGQIIGSLSGAAITSYTTPA----TTFIVMGIVFAVSSLFLI 393
Cdd:TIGR00895 130 VSEYAPKRFRGTAVGL----MFCGYPIGAAVGGFLAGWLIPVfgwrSLFYVGGIAPLLLLLLLM 189
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
19-118 |
7.42e-04 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 41.46 E-value: 7.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 19 FIAIAGLTVLVPLLPIYMASLQnLSVVEIQLWSGIAIAapavTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMAL 98
Cdd:pfam12832 9 FFYFAALGCLLPYWGLYLRSIG-LNPSEIGLITAILPL----TRILAPPIWGWLADRTGKRKAVVRLASILAAVLFLSVL 83
|
90 100
....*....|....*....|.
gi 446532703 99 CTTP-LQFVLVRLLQGLFGGV 118
Cdd:pfam12832 84 FIPIsLTFWWLALLVVLFSFF 104
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
62-183 |
7.61e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 41.57 E-value: 7.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 62 TMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGL-FGGVVDASSAFASAEAPAEDRGKVLG 140
Cdd:TIGR00895 65 MAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLgLGGLMPNLNALVSEYAPKRFRGTAVG 144
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 446532703 141 RLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIF 183
Cdd:TIGR00895 145 LMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLL 187
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
11-186 |
1.11e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 41.06 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 11 FRILWLSQFIAIAGLTVLVPLLPIYMASLQNLSVVEIQLWSGIAiaapAVTTMIASPIWGKLGDKISRKWMVLRALLGLA 90
Cdd:cd17353 215 FWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSIL----SIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQG 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 91 VCLFLMALCT-TPLQFVLVRLLQGLFGGvvdasSAFASAEAPAEDR------GKVLGRLQSSVSAGSLVGPLIGGVTASI 163
Cdd:cd17353 291 VAMFLLPFIGsVAVLFVLGVALIGFCYG-----GGFALFPALTADFfgtknaGTNYGLLYTAKGVGGLIGPIIAAYVLYT 365
|
170 180
....*....|....*....|...
gi 446532703 164 LGFSAlLMSIAVITFIVCIFGAL 186
Cdd:cd17353 366 GGYNA-AFIIAAALSLVALALAL 387
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
8-186 |
1.30e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 40.72 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 8 RSNFRILWLSQFIAIAGLTVLVPLLPIYMASLQNLSVVEIQLWSGIAIAApavttMIASPIWGKLGDKISRKWMVLRALL 87
Cdd:cd17355 209 SASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFN-----IVGRLLSGWLGDRYSPRRLLAASYA 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 88 GLAVCLFLMALCTTPLQFVLV-RLLQGLF-GGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILG 165
Cdd:cd17355 284 LRALGLALLLLLPFPPLALLLfAALFGLGwGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTG 363
|
170 180
....*....|....*....|.
gi 446532703 166 FSALLMSIAVITFIVCIFGAL 186
Cdd:cd17355 364 SYTAAWALAVALGLIAALLVL 384
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
68-326 |
1.41e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 40.59 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 68 IWGKLGDKISRKWMVLRALLGLAVCLFLMALCTT--------PLQFVLVRLLQGL-----FGGVVdassAFASAEAPAED 134
Cdd:cd17369 63 VFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTyaqigilaPILLVLLRLLQGLalggeWGGAV----LMAVEHAPPKR 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 135 RGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSAL---------LMSIAVItfIVCIFGALKLIETTHMPKSQtpniNKG 205
Cdd:cd17369 139 RGFYGSFPQLGAPVGLLLATGVFLLLSALLSDEAFlswgwripfLLSAVLV--AVGLYIRLRLEETPVFRRAK----EAG 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 206 IRRSFQCLLCTQQTCRFIIVGVLANFAMYG---MLTALSpLASSVNHTAIDDRSV--IGFLQSAFWTASIlsaPLWGRFN 280
Cdd:cd17369 213 QVVRAPLVEVLRRHWRALLLAIGLRLAENVlfyLFTTFA-LSYATQTLGVDRSTVllAVLIASVVAAITI---PLFGWLS 288
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 446532703 281 DKSYVKSVYIFATIACGCSAIL--------QGLATNIEFLMAARILQGLTYSAL 326
Cdd:cd17369 289 DRVGRRPVYLAGALLAALFAFPffwlldtgSTWLIVLAAVVVLGVLHGMMYGPQ 342
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
68-239 |
2.94e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 39.51 E-value: 2.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 68 IWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAEDRgkvLGRLQSSV- 146
Cdd:PRK11102 45 FYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASVVINALMRDMFPKEE---FSRMMSFVt 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 147 ---SAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIFGALKLIETTHMPKSQTPNINKGIrRSFQCLLCTQQTCRFI 223
Cdd:PRK11102 122 lvmTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPETLPKERRQPFHLRTTI-RNFASLFRHKRVLGYM 200
|
170
....*....|....*.
gi 446532703 224 IVGVLANFAMYGMLTA 239
Cdd:PRK11102 201 LASGFSFAGMFSFLTA 216
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
52-191 |
3.56e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 39.18 E-value: 3.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 52 GIAIAAPAVTTMIASPIWGKLGDKISRKWMVLRALLGLAVCLFLMALCTTPLQFVLVRLLQGLFGGV-VDASSAFASAEA 130
Cdd:cd17312 41 GIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMgWPPCVKLLGNWF 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446532703 131 PAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIAVITFIVCIFGALKLIET 191
Cdd:cd17312 121 SKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDS 181
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
11-158 |
4.78e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 38.93 E-value: 4.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 11 FRILWLSQFIAIAGLTVLVpllpIYMASLQNLSVVEIQLWSGIAIAAPAVTTMIASPIWG----KLGDKISRKWMVLrAL 86
Cdd:cd17314 208 FWILFIAIFLVLIGGFLFI----ANMASLVRSLQLDAPSFVTKLMSIYGLFNAFGRLLWGivadFFGGRLSTLSILL-TI 282
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446532703 87 LGLAVCLFLMALCTTPLQFVLVRLLQGL-FGGVVDASSAFASAEAPAEDRGKVLGRLQSSVSAGSLVGPLIGG 158
Cdd:cd17314 283 LGLGLCAFLFLLKMTPVGLVLTGSLLGFsYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGA 355
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
16-183 |
5.51e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 38.71 E-value: 5.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 16 LSQFIAIAGLTVLVPLLPIYMASLqNLSVVEIQLWSGIAIAAPAVTTMIASPiwgkLGDKISRKWMVLRALLGLAVCLFL 95
Cdd:cd17323 6 FLTFVVTFGSSIYSPALPQIAEDF-HVSEEVANLGVSLFVLGFGLGPLIWAP----LSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 96 MALCTTPLQFVLVRLLQGLFGGVVDASSAFASA-EAPAEDRGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSA---LLM 171
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIAdLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWifwFLA 160
|
170
....*....|..
gi 446532703 172 SIAVITFIVCIF 183
Cdd:cd17323 161 IISGFCLILIFL 172
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
239-392 |
5.52e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 38.79 E-value: 5.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 239 ALSPLASSVNHTAIDDRSVIGFLQSAFWTASILSAPLWGRFNDKSYVKSVYIFATIACGCSAILQGLATNIEFLMAARIL 318
Cdd:cd17312 21 NFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGL 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446532703 319 QGLTYSALIQSVMFVVVNACHQQLKGTFVGTTNSMLVIGQIIGSLSGAAITSYTTPATTFIVMGIVFAVSSLFL 392
Cdd:cd17312 101 NGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIIL 174
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
16-183 |
6.60e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 38.36 E-value: 6.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 16 LSQFIAIAGLTVLVPLLpiymASLQNLSVVEIQLWSGIAIAAPAVTTMIASPIWGKlgdKISRKWMVLRALLGLAVCLFL 95
Cdd:cd17490 205 LQQMITFSTTFGFTPLI----AKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYK---KLGERNTIIIGFLLLGAYCFL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446532703 96 MALCTTPLQFVLVRLLQGLFGGVVDASSAFASAEAPAED-RGKVLGRLQSSVSAGSLVGPLIGGVTASILGFSALLMSIA 174
Cdd:cd17490 278 IPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEqRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIG 357
|
....*....
gi 446532703 175 VITFIVCIF 183
Cdd:cd17490 358 VIALLAAIL 366
|
|
| |
