|
Name |
Accession |
Description |
Interval |
E-value |
| murB |
PRK13906 |
UDP-N-acetylmuramate dehydrogenase; |
1-307 |
0e+00 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 184386 [Multi-domain] Cd Length: 307 Bit Score: 614.52 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 1 MINKDIYQALQQLIPNEKIKVDEPLKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNEIPVTYLGNGSNIIIREGGIR 80
Cdd:PRK13906 1 MINKDIYQALQQLIPNEKIKVDEPLKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNEIPVTYLGNGSNIIIREGGIR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 81 GIVISLLSLDHIEVSDDAIIAGSGAAIIDVSRVARDYALTGLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQ 160
Cdd:PRK13906 81 GIVISLLSLDHIEVSDDAIIAGSGAAIIDVSRVARDYALTGLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 161 GSIIKLTTKELELDYRNSIIQKEHLVVLEAAFTLAPGKMTEIQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHFAGKLI 240
Cdd:PRK13906 161 GSLIKLTTKELELDYRNSIIQKEHLVVLEAAFTLAPGKMTEIQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHFAGKLI 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446531089 241 QDSNLQGHRIGGVEVSTKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRIIGEHPKES 307
Cdd:PRK13906 241 QDSNLQGHRIGGVEVSTKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRIIGEHPKES 307
|
|
| MurB |
COG0812 |
UDP-N-acetylenolpyruvoylglucosamine reductase [Cell wall/membrane/envelope biogenesis]; ... |
23-300 |
4.92e-147 |
|
UDP-N-acetylenolpyruvoylglucosamine reductase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylenolpyruvoylglucosamine reductase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440574 [Multi-domain] Cd Length: 279 Bit Score: 414.03 E-value: 4.92e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 23 EPLKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNEIPVTYLGNGSNIIIREGGIRGIVISLLSLDHIEVSDDAII-A 101
Cdd:COG0812 1 EPLAPHTTFRIGGPADLLVEPASEEELAALLRAAREAGLPVLVLGGGSNLLVRDDGFDGLVIRLGRLKGIEVDDGVLVtA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 102 GSGAAIIDVSRVARDYALTGLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQGSIIKLTTKELELDYRNSIIQ 181
Cdd:COG0812 81 GAGENWHDLVRFALEAGLSGLEFLAGIPGTVGGAPVMNAGAYGGEIKDVLESVEVLDRTGEVRTLSAEECGFGYRDSIFK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 182 KEHLVVLEAAFTLAPGKMTEIQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHFAGKLIQDSNLQGHRIGGVEVSTKHAG 261
Cdd:COG0812 161 RERYIILSVTFRLKKGDPAEIAAVMDAVLAIRRSKQPLELPSAGSFFKNPPGDSAGWLIEQAGLKGYRIGGAQVSEKHAN 240
|
250 260 270
....*....|....*....|....*....|....*....
gi 446531089 262 FMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRII 300
Cdd:COG0812 241 FLVNRGGATAADVLALIEEVQARVKEKFGVELEPEVRII 279
|
|
| murB |
TIGR00179 |
UDP-N-acetylenolpyruvoylglucosamine reductase; This model describes MurB, ... |
25-301 |
9.63e-81 |
|
UDP-N-acetylenolpyruvoylglucosamine reductase; This model describes MurB, UDP-N-acetylenolpyruvoylglucosamine reductase, which is also called UDP-N-acetylmuramate dehydrogenase. It is part of the pathway for the biosynthesis of the UDP-N-acetylmuramoyl-pentapeptide that is a precursor of bacterial peptidoglycan. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 272945 [Multi-domain] Cd Length: 284 Bit Score: 246.21 E-value: 9.63e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 25 LKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNEIPVTYLGNGSNIIIREGGIRGIVISLLSL-DHIEVSDDAIIAGS 103
Cdd:TIGR00179 1 LAEFTTYKIGGNARHIVCPESIEQLVNVLDNAKEEDQPLLILGEGSNLLILDDGRGGVIINLGKGiDIEDDEGEYVHVGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 104 GAAIIDVSRVARDYALTGLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQGSIIKLTTKELELDYRNSIIQKE 183
Cdd:TIGR00179 81 GENWHKLVKYALKNGLSGLEFLAGIPGTVGGAVIMNAGAYGVEISEVLVYATILLATGKTEWLTNEQLGFGYRTSIFQHK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 184 HL-VVLEAAFTLAPGKMTE-----IQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHFAGKLIQDSNLQGHRIGGVEVST 257
Cdd:TIGR00179 161 YVgLVLKAEFQLTLGFGTRldpetITAQQVFNKVCRMRTSHYPDPNAGSFFKNPSPNHAGRLIEECGLKGYQIGGAAVSK 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 446531089 258 KHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRIIG 301
Cdd:TIGR00179 241 QHANFLVNIDNAKSEDVLDLIEHVKAEVGEKYGILLEPEVKIIG 284
|
|
| MurB_C |
pfam02873 |
UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Members of this family are ... |
202-300 |
5.38e-54 |
|
UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Members of this family are UDP-N-acetylenolpyruvoylglucosamine reductase enzymes EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan.
Pssm-ID: 460730 [Multi-domain] Cd Length: 99 Bit Score: 170.99 E-value: 5.38e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 202 IQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHFAGKLIQDSNLQGHRIGGVEVSTKHAGFMVNVDNGTATDYENLIHYV 281
Cdd:pfam02873 1 IRAAMLELRRRRLAKQPLDPPSAGSFFKNPVGHSAGWLIEQAGLKGYRIGGAQVSEKHANFLVNTGGATAADVLALIEEV 80
|
90
....*....|....*....
gi 446531089 282 QKTVKEKFGIELNREVRII 300
Cdd:pfam02873 81 RERVKEKFGVELEPEVRII 99
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| murB |
PRK13906 |
UDP-N-acetylmuramate dehydrogenase; |
1-307 |
0e+00 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 184386 [Multi-domain] Cd Length: 307 Bit Score: 614.52 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 1 MINKDIYQALQQLIPNEKIKVDEPLKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNEIPVTYLGNGSNIIIREGGIR 80
Cdd:PRK13906 1 MINKDIYQALQQLIPNEKIKVDEPLKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNEIPVTYLGNGSNIIIREGGIR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 81 GIVISLLSLDHIEVSDDAIIAGSGAAIIDVSRVARDYALTGLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQ 160
Cdd:PRK13906 81 GIVISLLSLDHIEVSDDAIIAGSGAAIIDVSRVARDYALTGLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 161 GSIIKLTTKELELDYRNSIIQKEHLVVLEAAFTLAPGKMTEIQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHFAGKLI 240
Cdd:PRK13906 161 GSLIKLTTKELELDYRNSIIQKEHLVVLEAAFTLAPGKMTEIQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHFAGKLI 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446531089 241 QDSNLQGHRIGGVEVSTKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRIIGEHPKES 307
Cdd:PRK13906 241 QDSNLQGHRIGGVEVSTKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRIIGEHPKES 307
|
|
| murB |
PRK13905 |
UDP-N-acetylmuramate dehydrogenase; |
14-302 |
2.06e-164 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 237553 [Multi-domain] Cd Length: 298 Bit Score: 458.81 E-value: 2.06e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 14 IPNEKIKVDEPLKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNEIPVTYLGNGSNIIIREGGIRGIVISL-LSLDHI 92
Cdd:PRK13905 8 ALRGRLLENEPLARYTSFRVGGPADYLVEPADIEDLQEFLKLLKENNIPVTVLGNGSNLLVRDGGIRGVVIRLgKGLNEI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 93 EVSDDAIIAGSGAAIIDVSRVARDYALTGLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQGSIIKLTTKELE 172
Cdd:PRK13905 88 EVEGNRITAGAGAPLIKLARFAAEAGLSGLEFAAGIPGTVGGAVFMNAGAYGGETADVLESVEVLDRDGEIKTLSNEELG 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 173 LDYRNSIIQKEHLVVLEAAFTLAPGKMTEIQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHFAGKLIQDSNLQGHRIGG 252
Cdd:PRK13905 168 FGYRHSALQEEGLIVLSATFQLEPGDKEEIKARMDELLARREATQPLEYPSAGSVFKNPPGHFAGKLIEEAGLKGYRIGG 247
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 446531089 253 VEVSTKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRIIGE 302
Cdd:PRK13905 248 AQVSEKHANFIINTGGATAADIEDLIEHVQKTVKEKFGVELEWEVRIIGE 297
|
|
| MurB |
COG0812 |
UDP-N-acetylenolpyruvoylglucosamine reductase [Cell wall/membrane/envelope biogenesis]; ... |
23-300 |
4.92e-147 |
|
UDP-N-acetylenolpyruvoylglucosamine reductase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylenolpyruvoylglucosamine reductase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440574 [Multi-domain] Cd Length: 279 Bit Score: 414.03 E-value: 4.92e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 23 EPLKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNEIPVTYLGNGSNIIIREGGIRGIVISLLSLDHIEVSDDAII-A 101
Cdd:COG0812 1 EPLAPHTTFRIGGPADLLVEPASEEELAALLRAAREAGLPVLVLGGGSNLLVRDDGFDGLVIRLGRLKGIEVDDGVLVtA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 102 GSGAAIIDVSRVARDYALTGLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQGSIIKLTTKELELDYRNSIIQ 181
Cdd:COG0812 81 GAGENWHDLVRFALEAGLSGLEFLAGIPGTVGGAPVMNAGAYGGEIKDVLESVEVLDRTGEVRTLSAEECGFGYRDSIFK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 182 KEHLVVLEAAFTLAPGKMTEIQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHFAGKLIQDSNLQGHRIGGVEVSTKHAG 261
Cdd:COG0812 161 RERYIILSVTFRLKKGDPAEIAAVMDAVLAIRRSKQPLELPSAGSFFKNPPGDSAGWLIEQAGLKGYRIGGAQVSEKHAN 240
|
250 260 270
....*....|....*....|....*....|....*....
gi 446531089 262 FMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRII 300
Cdd:COG0812 241 FLVNRGGATAADVLALIEEVQARVKEKFGVELEPEVRII 279
|
|
| PRK12436 |
PRK12436 |
UDP-N-acetylmuramate dehydrogenase; |
1-302 |
1.12e-144 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 171497 [Multi-domain] Cd Length: 305 Bit Score: 409.40 E-value: 1.12e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 1 MINKDIYQALQQLIPNEKIKVDEPLKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNEIPVTYLGNGSNIIIREGGIR 80
Cdd:PRK12436 1 MNMQEVYEYLSTVLPEGHVKQDEMLKNHTHIKVGGKADVFVAPTNYDEIQEVIKYANKYNIPVTFLGNGSNVIIKDGGIR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 81 GIVISLLSLDHIEVSDDAIIAGSGAAIIDVSRVARDYALTGLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQ 160
Cdd:PRK12436 81 GITVSLIHITGVTVTGTTIVAQCGAAIIDVSRIALDHNLTGLEFACGIPGSVGGALYMNAGAYGGEISFVLTEAVVMTGD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 161 GSIIKLTTKELELDYRNSIIQKEHLVVLEAAFTLAPGKMTEIQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHFAGKLI 240
Cdd:PRK12436 161 GELRTLTKEAFEFGYRKSVFANNHYIILEARFELEEGVYEEIKAKMDDLTFKRESKQPLEYPSCGSVFKRPPNNFAGKLI 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446531089 241 QDSNLQGHRIGGVEVSTKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRIIGE 302
Cdd:PRK12436 241 QESGLQGKRIGGVEVSLKHAGFMVNVDNGTAQDYIDLIHFVQKTVEEKFGVKLEREVRIIGE 302
|
|
| murB |
TIGR00179 |
UDP-N-acetylenolpyruvoylglucosamine reductase; This model describes MurB, ... |
25-301 |
9.63e-81 |
|
UDP-N-acetylenolpyruvoylglucosamine reductase; This model describes MurB, UDP-N-acetylenolpyruvoylglucosamine reductase, which is also called UDP-N-acetylmuramate dehydrogenase. It is part of the pathway for the biosynthesis of the UDP-N-acetylmuramoyl-pentapeptide that is a precursor of bacterial peptidoglycan. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 272945 [Multi-domain] Cd Length: 284 Bit Score: 246.21 E-value: 9.63e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 25 LKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNEIPVTYLGNGSNIIIREGGIRGIVISLLSL-DHIEVSDDAIIAGS 103
Cdd:TIGR00179 1 LAEFTTYKIGGNARHIVCPESIEQLVNVLDNAKEEDQPLLILGEGSNLLILDDGRGGVIINLGKGiDIEDDEGEYVHVGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 104 GAAIIDVSRVARDYALTGLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQGSIIKLTTKELELDYRNSIIQKE 183
Cdd:TIGR00179 81 GENWHKLVKYALKNGLSGLEFLAGIPGTVGGAVIMNAGAYGVEISEVLVYATILLATGKTEWLTNEQLGFGYRTSIFQHK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 184 HL-VVLEAAFTLAPGKMTE-----IQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHFAGKLIQDSNLQGHRIGGVEVST 257
Cdd:TIGR00179 161 YVgLVLKAEFQLTLGFGTRldpetITAQQVFNKVCRMRTSHYPDPNAGSFFKNPSPNHAGRLIEECGLKGYQIGGAAVSK 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 446531089 258 KHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRIIG 301
Cdd:TIGR00179 241 QHANFLVNIDNAKSEDVLDLIEHVKAEVGEKYGILLEPEVKIIG 284
|
|
| PRK14649 |
PRK14649 |
UDP-N-acetylmuramate dehydrogenase; |
22-301 |
4.37e-67 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 173112 [Multi-domain] Cd Length: 295 Bit Score: 211.62 E-value: 4.37e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 22 DEPLKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNEIPVTYLGNGSNIIIREGGIRGIVISLLSLD---HIEVSDDA 98
Cdd:PRK14649 6 NEPLAPYTSWRIGGPARYFVEPTTPDEAIAAAAWAEQRQLPLFWLGGGSNLLVRDEGFDGLVARYRGQRwelHEHGDTAE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 99 IIAGSGAAIIDVSRVARDYALTGLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQGSIIKLTTKELELDYRNS 178
Cdd:PRK14649 86 VWVEAGAPMAGTARRLAAQGWAGLEWAEGLPGTIGGAIYGNAGCYGGDTATVLIRAWLLLNGSECVEWSVHDFAYGYRTS 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 179 IIQK--------EHLVVLEAAFTLAPGKMTEIQAKMDDLTERRESKQPLEyPSCGSVFQRPPGHFAGKLIQDSNLQGHRI 250
Cdd:PRK14649 166 VLKQlradgitwRPPLVLAARFRLHRDDPTALAARMEAIAAERKQKTPAG-SSCGSVFKNPPGDSAGRLIEAAGLKGTRI 244
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 446531089 251 GGVEVSTKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRIIG 301
Cdd:PRK14649 245 GDAEIATRHANYIINLGGARAADILRLIDLARTRVLAQFGIELELEVRIIG 295
|
|
| PRK14652 |
PRK14652 |
UDP-N-acetylmuramate dehydrogenase; |
18-302 |
1.13e-64 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 237777 [Multi-domain] Cd Length: 302 Bit Score: 205.49 E-value: 1.13e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 18 KIKVDEPLKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNEIPVTYLGNGSNIIIREGGIRGIVISLLSLDHIEVSDD 97
Cdd:PRK14652 17 EVLRDAPLAPRTAVRVGGPADLLVRPADPDALSALLRAVRELGVPLSILGGGANTLVADAGVRGVVLRLPQDFPGESTDG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 98 A-IIAGSGAAIIDVSRVARDYALTGLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDyALCVNEQGSIIKLTTKELELDYR 176
Cdd:PRK14652 97 GrLVLGAGAPISRLPARAHAHGLVGMEFLAGIPGTLGGAVAMNAGTKLGEMKDVVT-AVELATADGAGFVPAAALGYAYR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 177 NSIIQKEHlVVLEAAFTLAPGKMTEIQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHFAGKLIQDSNLQGHRIGGVEVS 256
Cdd:PRK14652 176 TCRLPPGA-VITRVEVRLRPGDVAASEALMRADRERRRRTQPLDRPTFGSTFTNPPGDYAGRLVEAVGLKGHRVGGAIWS 254
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 446531089 257 TKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRIIGE 302
Cdd:PRK14652 255 PVHANFVTNLGGATARDVLALVRLARARVKERFGIALETEVRLLGE 300
|
|
| PRK14653 |
PRK14653 |
UDP-N-acetylmuramate dehydrogenase; |
21-299 |
6.59e-63 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 237778 [Multi-domain] Cd Length: 297 Bit Score: 200.83 E-value: 6.59e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 21 VDEPLKRYTYTKTGGNADFYITPTKNEEVQAVVKYaYQNEIPVTYLGNGSNIIIREGGIRGIVISLLSLDHIEVSDDAII 100
Cdd:PRK14653 18 INEEMKCHVSFKIGGPVPLFAIPNSTNGFIETINL-LKEGIEVKILGNGTNVLPKDEPMDFVVVSTERLDDIFVDNDKII 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 101 AGSGAAIIDVSRVARDYALTGLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALcVNEQGSIIKLTTKELELDYRNSII 180
Cdd:PRK14653 97 CESGLSLKKLCLVAAKNGLSGFENAYGIPGSVGGAVYMNAGAYGWETAENIVEVV-AYDGKKIIRLGKNEIKFSYRNSIF 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 181 QKE-HLVVLEAAFTLAPGKMTEIQAKMDDLTERRESKQPLEYPSCGSVFQRP-PGHFAGKLIQDSNLQGHRIGGVEVSTK 258
Cdd:PRK14653 176 KEEkDLIILRVTFKLKKGNKNEIYNLMLETMKKRVEKQPLEFPSAGSVFKRPrKDFYVGSAIEKLGLKGFSIGGAQISEK 255
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 446531089 259 HAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRI 299
Cdd:PRK14653 256 HAGFIINYNNAKAEDVLKLIEYVKDKIYENYNVELETEIEI 296
|
|
| MurB_C |
pfam02873 |
UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Members of this family are ... |
202-300 |
5.38e-54 |
|
UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Members of this family are UDP-N-acetylenolpyruvoylglucosamine reductase enzymes EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan.
Pssm-ID: 460730 [Multi-domain] Cd Length: 99 Bit Score: 170.99 E-value: 5.38e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 202 IQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHFAGKLIQDSNLQGHRIGGVEVSTKHAGFMVNVDNGTATDYENLIHYV 281
Cdd:pfam02873 1 IRAAMLELRRRRLAKQPLDPPSAGSFFKNPVGHSAGWLIEQAGLKGYRIGGAQVSEKHANFLVNTGGATAADVLALIEEV 80
|
90
....*....|....*....
gi 446531089 282 QKTVKEKFGIELNREVRII 300
Cdd:pfam02873 81 RERVKEKFGVELEPEVRII 99
|
|
| PRK14650 |
PRK14650 |
UDP-N-acetylmuramate dehydrogenase; |
25-301 |
1.81e-45 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 173113 [Multi-domain] Cd Length: 302 Bit Score: 156.16 E-value: 1.81e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 25 LKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNEIPVTYLGNGSNIIIREGG-IRGIVISLLSLDHIEVSDDAIIAGS 103
Cdd:PRK14650 21 LANYTTYKIGGISKLFLTPKTIKDAEHIFKAAIEEKIKIFILGGGSNILINDEEeIDFPIIYTGHLNKIEIHDNQIVAEC 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 104 GAAIIDVSRVARDYALTGLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQGSIIKLTTKELELDYRNSIIQKE 183
Cdd:PRK14650 101 GTNFEDLCKFALQNELSGLEFIYGLPGTLGGAIWMNARCFGNEISEILDKITFIDEKGKTICKKFKKEEFKYKISPFQNK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 184 HLVVLEAAFTLAPGKMTEIQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHF--AGKLIQDSNLQGHRIGGVEVSTKHAG 261
Cdd:PRK14650 181 NTFILKATLNLKKGNKKHIEEIMKQNKQIRINKGHYLFPSSGSTFKNNKAFLkpTGQIIEECKLKGLSIGGATVSHYHGN 260
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 446531089 262 FMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRIIG 301
Cdd:PRK14650 261 FIININNATSKDIKTLIEKVKTEVQIKTGFLLEEEVLYIG 300
|
|
| PRK14651 |
PRK14651 |
UDP-N-acetylmuramate dehydrogenase; |
24-306 |
5.92e-41 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 237776 [Multi-domain] Cd Length: 273 Bit Score: 143.42 E-value: 5.92e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 24 PLKRYTYTKTGGNADFYITPTKNEEVQAVvkyayqnEIPVTYLGNGSNIIIREGGIRGIVISLlSLDHIEVSDDAIIaGS 103
Cdd:PRK14651 8 PLARYTTLGVGGPAELWTVETHEQLAEAT-------EAPYRVLGGGSNLLVSDAGVPERVIRL-GGEFAEWDLDGWV-GG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 104 GAAIIDVSRVARDYALTGLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQGsIIKLTTKELELDYRNSIIQKE 183
Cdd:PRK14651 79 GVPLPGLVRRAARLGLSGLEGLVGIPAQVGGAVKMNAGTRFGEMADALHTVEIVHDGG-FHQYSPDELGFGYRHSGLPPG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 184 HlVVLEAAFTLAPGKMTEIQAKMDDLTERRESKQPLEYPSCGsvFQRPPGHFAGKLIQDSNLQGHRIGGVEVSTKHAGFM 263
Cdd:PRK14651 158 H-VVTRVRLKLRPSTPEAVLAKMALVDAARKGQPKKKSAGCA--FKNPPGDSAGRLIDEAGLKGTRVGDAMISPEHGNFI 234
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 446531089 264 VNVDNGTATDyenlIHYVQKTVKEKFGIELNREVRIIGEHPKE 306
Cdd:PRK14651 235 VNLGGATAAD----VHALLRRVRARVGLPLELEWELWPEQLPE 273
|
|
| murB |
PRK13904 |
UDP-N-acetylmuramate dehydrogenase; |
88-300 |
9.92e-41 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 184384 [Multi-domain] Cd Length: 257 Bit Score: 142.37 E-value: 9.92e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 88 SLDHIEVSDDAIIAGSGAAIIDVSRVARDYALTGLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDyALCVNeQGSIIKlt 167
Cdd:PRK13904 58 NFDYIKIDGECLEIGGATKSGKIFNYAKKNNLGGFEFLGKLPGTLGGLVKMNAGLKEYEISNNLE-SICTN-GGWIEK-- 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 168 tKELELDYRNSIIQKehlVVLEAAFTLAPGKMTEIQakmDDLTERRESkQPLEyPSCGSVFQRPPGHFAGKLIQDSNLQG 247
Cdd:PRK13904 134 -EDIGFGYRSSGING---VILEARFKKTHGFDEELL---EAFKSMRKN-QPKG-PSFGSCFKNPKGDYAGRLIEAVGLKG 204
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 446531089 248 HRIGGVEVSTKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRII 300
Cdd:PRK13904 205 YCKGGAGFSEEHANFLVNLGGATFEDALDLIELAKKRVLEEFGINLEEEVIIL 257
|
|
| PRK14648 |
PRK14648 |
UDP-N-acetylmuramate dehydrogenase; |
24-302 |
4.04e-35 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 173111 [Multi-domain] Cd Length: 354 Bit Score: 130.23 E-value: 4.04e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 24 PLKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNEIPVTYLGNGSNIIIREGGIRGIVISLLSLD--HIEVSDDAII- 100
Cdd:PRK14648 17 PLAERCSFRIGGAAQFWAEPRSCTQLRALIEEAQRARIPLSLIGGGSNVLIADEGVPGLMLSLRRFRslHTQTQRDGSVl 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 101 --AGSGAAIIDVSRVARDYALTGLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYAL----------------------- 155
Cdd:PRK14648 97 vhAGAGLPVAALLAFCAHHALRGLETFAGLPGSVGGAAYMNARCYGRAIADCFHSARtlvlhpvrsrakelpevrknaqd 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 156 ----CVNEQG------SIIKLTTKELELDYRNSIIQKEHLVVLEAA--------FTLAPGKMTEIQAKMDDLTERRESKQ 217
Cdd:PRK14648 177 krgeCLGLDGgpftcsSFQTVFARAGDWGYKRSPFQSPHGVELHAGrrlilslcVRLTPGNPAQIRKHMQEKIADRISKG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 218 PLEYPSCGSVFQRPP--GHFAGKLIQDSNLQGHRIGGVEVSTKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNR 295
Cdd:PRK14648 257 QFRFPSAGSAFKNNPafGKPSGILIEEAGLRGTSCGAAQVAPWHGNLIINTGNATAHQVRTLLRVVRQRVFETHGVWLER 336
|
....*..
gi 446531089 296 EVRIIGE 302
Cdd:PRK14648 337 EIIFSGE 343
|
|
| murB |
PRK00046 |
UDP-N-acetylmuramate dehydrogenase; |
36-300 |
1.47e-31 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 234593 [Multi-domain] Cd Length: 334 Bit Score: 120.25 E-value: 1.47e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 36 NADFYITPTKNEEVQAVVKYAYQNEIPVTYLGNGSNIIIREGgIRGIVI--SLLSLDHIEVSDDAII--AGSGAAIID-V 110
Cdd:PRK00046 20 RARHLVEAESEEQLLEALADARAAGLPVLVLGGGSNVLFTED-FDGTVLlnRIKGIEVLSEDDDAWYlhVGAGENWHDlV 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 111 SR-VARDYAltGLE-FACgIPGSIGGAVYMNAGAYGGEVKDCIDYALCVN-EQGSIIKLTTKELELDYRNSI-------- 179
Cdd:PRK00046 99 LWtLQQGMP--GLEnLAL-IPGTVGAAPIQNIGAYGVELKDVCDYVEALDlATGEFVRLSAAECRFGYRDSIfkheypdr 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 180 ---------IQKEHLVVLEAA--FTLAPGKMTeIQAKMDDLTERRESK--QPLEYPSCGSVFQRP--------------P 232
Cdd:PRK00046 176 yaitavgfrLPKQWQPVLDYGdlARLDPDTVT-AQDVFDAVCAIRRSKlpDPKVLGNAGSFFKNPvvsaeqfeallaqyP 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 233 G--HF----------AGKLIQDSNLQGHRIGGVEVSTKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRII 300
Cdd:PRK00046 255 DipHYpqadgsvklaAGWLIDQCGLKGFQIGGAAVHEKQALVLVNYGNATGADVLALARHIQQDVREKFGVELEPEPRFI 334
|
|
| FAD_binding_4 |
pfam01565 |
FAD binding domain; This family consists of various enzymes that use FAD as a co-factor, most ... |
37-167 |
1.83e-28 |
|
FAD binding domain; This family consists of various enzymes that use FAD as a co-factor, most of the enzymes are similar to oxygen oxidoreductase. One of the enzymes Vanillyl-alcohol oxidase (VAO) has a solved structure, the alignment includes the FAD binding site, called the PP-loop, between residues 99-110. The FAD molecule is covalently bound in the known structure, however the residue that links to the FAD is not in the alignment. VAO catalyzes the oxidation of a wide variety of substrates, ranging form aromatic amines to 4-alkylphenols. Other members of this family include D-lactate dehydrogenase, this enzyme catalyzes the conversion of D-lactate to pyruvate using FAD as a co-factor; mitomycin radical oxidase, this enzyme oxidizes the reduced form of mitomycins and is involved in mitomycin resistance. This family includes MurB an UDP-N-acetylenolpyruvoylglucosamine reductase enzyme EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan.
Pssm-ID: 426326 [Multi-domain] Cd Length: 139 Bit Score: 106.52 E-value: 1.83e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 37 ADFYITPTKNEEVQAVVKYAYQNEIPVTYLGNGSNIIIREGGIRGIVISLLSLDHIEVSDDA---IIAGSGAAIIDVSRV 113
Cdd:pfam01565 1 PAAVVLPESEEEVAAIVRLANENGLPVLPRGGGSSLLGGAVQTGGIVLDLSRLNGILEIDPEdgtATVEAGVTLGDLVRA 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 446531089 114 ARDYALT-GLEFACGIPGSIGGAVYMNAGAYGGE----VKDCIDYALCVNEQGSIIKLT 167
Cdd:pfam01565 81 LAAKGLLlGLDPGSGIPGTVGGAIATNAGGYGSEkyglTRDNVLGLEVVLADGEVVRLG 139
|
|
| murB |
PRK13903 |
UDP-N-acetylmuramate dehydrogenase; |
22-301 |
9.65e-26 |
|
UDP-N-acetylmuramate dehydrogenase;
Pssm-ID: 237552 [Multi-domain] Cd Length: 363 Bit Score: 105.04 E-value: 9.65e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 22 DEPLKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNEIPVTYLGNGSNIIIREGGIRGIVISLLSLD-HIEVSDDAII 100
Cdd:PRK13903 18 DVPLAPLTTLRVGGPARRLVTCTSTEELVAAVRELDAAGEPLLVLGGGSNLVIADDGFDGTVVRVATRGvTVDCGGGLVR 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 101 AGSGAAIIDVsrVARDYA--LTGLEFACGIPGSIGGAVYMNAGAYGGEVKDCI------DYALcvneqGSIIKLTTKELE 172
Cdd:PRK13903 98 AEAGAVWDDV--VARTVEagLGGLECLSGIPGSAGATPVQNVGAYGQEVSDTItrvrllDRRT-----GEVRWVPAADLG 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 173 LDYRNSII-QKEHLVVLEAAFTLAPGKMT------EIQAKMD-------DLTERRE-------SKQPLEYP------SCG 225
Cdd:PRK13903 171 FGYRTSVLkHSDRAVVLEVEFQLDPSGLSaplrygELARALGvepgervPPAAVREavlalraGKGMVLDPadhdtwSAG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 226 SVFQRP----------------------------PGHF---AGKLIQDSNL-QGHRIGG--VEVSTKHAGFMVNVDNGTA 271
Cdd:PRK13903 251 SFFTNPvvspavaerlaarvaerlgdpvprypagDGGVklsAAWLIERAGFgKGYPGGGapARLSTKHTLALTNRGGATT 330
|
330 340 350
....*....|....*....|....*....|
gi 446531089 272 TDYENLIHYVQKTVKEKFGIELNREVRIIG 301
Cdd:PRK13903 331 ADLVALAREVRDGVRDAFGVTLVPEPVLVG 360
|
|
| GlcD |
COG0277 |
FAD/FMN-containing lactate dehydrogenase/glycolate oxidase [Energy production and conversion]; |
1-144 |
1.03e-10 |
|
FAD/FMN-containing lactate dehydrogenase/glycolate oxidase [Energy production and conversion];
Pssm-ID: 440046 [Multi-domain] Cd Length: 462 Bit Score: 62.22 E-value: 1.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 1 MINKDIYQALQQLIPNEKIKVDEPLKRYTYTKTG---GNADFYITPTKNEEVQAVVKYAYQNEIPVTYLGNGSNIiirEG 77
Cdd:COG0277 1 MLTAALLAALRAILAGRVLTDPADRAAYARDGNSlyrGRPDAVVRPRSTEDVAAVVRLAAEHGVPVVPRGGGTGL---AG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446531089 78 GI----RGIVISLLSLDHI-EVSDDA--IIAGSGAAIIDVSRVARDYaltGLEFACGiPGS-----IGGAVYMNAG---- 141
Cdd:COG0277 78 GAvpldGGVVLDLSRMNRIlEVDPEDrtATVEAGVTLADLNAALAPH---GLFFPPD-PSSqgtatIGGNIATNAGgprs 153
|
....
gi 446531089 142 -AYG 144
Cdd:COG0277 154 lKYG 157
|
|
| |
