Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446523590  20 VIPPCLLPIGNRTLLEYQAESIRKMSNEKIFLT---LPEdyclsKFEERLLDS----LNIRAIYLSPNLSLGESIYQALD 92
Cdd:cd04181   18 TRPKPLLPIAGKPILEYIIERLARAGIDEIILVvgyLGE-----QIEEYFGDGskfgVNIEYVVQEEPLGTAGAVRNAED 92

                         90       100
                 ....*....|....*....|..
gi 446523590  93 SIGDYTFssdgLkLLHGDTLIN 114
Cdd:cd04181   93 FLGDDDF----L-VVNGDVLTD 109

NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Nucleotidyltransferases transfer nucleotides onto phosphosugars. The enzyme family includes Alpha-D-Glucose-1-Phosphate Cytidylyltransferase, Mannose-1-phosphate guanyltransferase, and Glucose-1-phosphate thymidylyltransferase. The products are activated sugars that are precursors for synthesis of lipopolysaccharide, glycolipids and polysaccharides.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446523590  20 VIPPCLLPIGNRTLLEYQAESIRKMSNEKIFLT---LPEdyclsKFEERLLDS----LNIRAIYLSPNLSLGESIYQALD 92
Cdd:cd04181   18 TRPKPLLPIAGKPILEYIIERLARAGIDEIILVvgyLGE-----QIEEYFGDGskfgVNIEYVVQEEPLGTAGAVRNAED 92

                         90       100
                 ....*....|....*....|..
gi 446523590  93 SIGDYTFssdgLkLLHGDTLIN 114
Cdd:cd04181   93 FLGDDDF----L-VVNGDVLTD 109

NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Nucleotidyltransferases transfer nucleotides onto phosphosugars. The enzyme family includes Alpha-D-Glucose-1-Phosphate Cytidylyltransferase, Mannose-1-phosphate guanyltransferase, and Glucose-1-phosphate thymidylyltransferase. The products are activated sugars that are precursors for synthesis of lipopolysaccharide, glycolipids and polysaccharides.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446523590  20 VIPPCLLPIGNRTLLEYQAESIRKMSNEKIFLT---LPEdyclsKFEERLLDS----LNIRAIYLSPNLSLGESIYQALD 92
Cdd:cd04181   18 TRPKPLLPIAGKPILEYIIERLARAGIDEIILVvgyLGE-----QIEEYFGDGskfgVNIEYVVQEEPLGTAGAVRNAED 92

                         90       100
                 ....*....|....*....|..
gi 446523590  93 SIGDYTFssdgLkLLHGDTLIN 114
Cdd:cd04181   93 FLGDDDF----L-VVNGDVLTD 109

The N-terminal domain of gamma subunit of the eIF-2B is a subfamily of glycosyltransferase 2; N-terminal domain of gamma subunit of the eukaryotic translation initiation factor 2B (eIF-2B): eIF-2B is a guanine nucleotide-exchange factor which mediates the exchange of GDP (bound to initiation factor eIF2) for GTP, generating active eIF2.GTP complex. EIF2B is a complex multimeric protein consisting of five subunits named alpha, beta, gamma, delta and epsilon. Subunit gamma shares sequence similarity with epsilon subunit, and with a family of bifunctional nucleotide-binding enzymes such as ADP-glucose pyrophosphorylase, suggesting that epsilon subunit may play roles in nucleotide binding activity. In yeast, eIF2B gamma enhances the activity of eIF2B-epsilon leading to the idea that these subunits form the catalytic subcomplex.

                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 446523590  21 IPPCLLPIGNRTLLEYQAESIRKMSNEKIFLTLPEDY 57
Cdd:cd04198   21 IPKALLPVANKPMIWYPLDWLEKAGFEDVIVVVPEEE 57