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Conserved domains on  [gi|446519981|ref|WP_000597327|]
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MULTISPECIES: diphosphomevalonate decarboxylase [Staphylococcus]

Protein Classification

diphosphomevalonate/mevalonate 3,5-bisphosphate decarboxylase family protein( domain architecture ID 11465556)

diphosphomevalonate/mevalonate 3,5-bisphosphate decarboxylase family protein similar to diphosphomevalonate decarboxylase (DMD) that catalyzes the decarboxylation of mevalonate 5-diphosphate (MVAPP) to isopentenyl diphosphate (IPP), and mevalonate 3,5-bisphosphate decarboxylase (MBD) that catalyzes the ATP-independent decarboxylation of (R)-mevalonate 3,5-bisphosphate to isopentenyl phosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MVD1 COG3407
Mevalonate pyrophosphate decarboxylase [Lipid transport and metabolism]; Mevalonate ...
 1-325 7.34e-157

Mevalonate pyrophosphate decarboxylase [Lipid transport and metabolism]; Mevalonate pyrophosphate decarboxylase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


:

Pssm-ID: 442633  Cd Length: 322  Bit Score: 441.55  E-value: 7.34e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981   1 MIKSGKARAHTNIALIKYWGKKDEALIIPMNNSISVTLEKFYTETKVTFNDQLTQDQFWLNGEKVSGKELEKISKYMDIV 80
Cdd:COG3407    2 AMGSATARAHSNIALIKYWGKRDEELNLPANPSLSLTLDAFYTTTTVEFDKDLAEDEFILNGEPQKGKFLPKISKFLDRV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981  81 RNRAGIDWYAEIESDNFVPTaaglassasayaalaaaCNQALDLQLSDKDLSRLARIGSGSASRSIYGGFAEWEKGYNDE 160
Cdd:COG3407   82 RALAGKSYHARIESENNFPTaaglassasgfaalalaANSAEGLDLDDRKLSRLARLGSGSACRSIFGGFVEWGKGEDDE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981 161 TSYAVPLESNHFedDLAMIFVVINQHSKKVPSRYGMSlTRNTSRFYQYWLDHIDEDLAEAKAAIQDKDFKRLGEVIEENG 240
Cdd:COG3407  162 DSYAVPIPAEDW--DLADIILVVDKGEKKVSSREGMK-TAETSPFYPAWVEQAEEDLEKLKEAIKAGDFEALGEIAESNA 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981 241 LRMHATNLGSTPPFTYLVQESYDVMALVHECREAGYPCYFTMDAGPNVKILVEKKNKQQIIDKLLTQFDNNQIIdSDIIA 320
Cdd:COG3407  239 LRMHATMMTSNPPFIYWKPNTLEVINAVRELREEGLPVYFTLDAGPNVKVLCPEEDAEKVAAFLAAELVNGQVI-VDKPG 317


                 ....*
gi 446519981 321 TGIEI 325
Cdd:COG3407  318 PGARL 322
 
Name Accession Description Interval E-value
MVD1 COG3407
Mevalonate pyrophosphate decarboxylase [Lipid transport and metabolism]; Mevalonate ...
 1-325 7.34e-157

Mevalonate pyrophosphate decarboxylase [Lipid transport and metabolism]; Mevalonate pyrophosphate decarboxylase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 442633  Cd Length: 322  Bit Score: 441.55  E-value: 7.34e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981   1 MIKSGKARAHTNIALIKYWGKKDEALIIPMNNSISVTLEKFYTETKVTFNDQLTQDQFWLNGEKVSGKELEKISKYMDIV 80
Cdd:COG3407    2 AMGSATARAHSNIALIKYWGKRDEELNLPANPSLSLTLDAFYTTTTVEFDKDLAEDEFILNGEPQKGKFLPKISKFLDRV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981  81 RNRAGIDWYAEIESDNFVPTaaglassasayaalaaaCNQALDLQLSDKDLSRLARIGSGSASRSIYGGFAEWEKGYNDE 160
Cdd:COG3407   82 RALAGKSYHARIESENNFPTaaglassasgfaalalaANSAEGLDLDDRKLSRLARLGSGSACRSIFGGFVEWGKGEDDE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981 161 TSYAVPLESNHFedDLAMIFVVINQHSKKVPSRYGMSlTRNTSRFYQYWLDHIDEDLAEAKAAIQDKDFKRLGEVIEENG 240
Cdd:COG3407  162 DSYAVPIPAEDW--DLADIILVVDKGEKKVSSREGMK-TAETSPFYPAWVEQAEEDLEKLKEAIKAGDFEALGEIAESNA 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981 241 LRMHATNLGSTPPFTYLVQESYDVMALVHECREAGYPCYFTMDAGPNVKILVEKKNKQQIIDKLLTQFDNNQIIdSDIIA 320
Cdd:COG3407  239 LRMHATMMTSNPPFIYWKPNTLEVINAVRELREEGLPVYFTLDAGPNVKVLCPEEDAEKVAAFLAAELVNGQVI-VDKPG 317


                 ....*
gi 446519981 321 TGIEI 325
Cdd:COG3407  318 PGARL 322
mevDPdecarb TIGR01240
diphosphomevalonate decarboxylase; This enzyme catalyzes the last step in the synthesis of ...
 5-308 7.20e-121

diphosphomevalonate decarboxylase; This enzyme catalyzes the last step in the synthesis of isopentenyl diphosphate (IPP) in the mevalonate pathway. Alternate names: mevalonate diphosphate decarboxylase; pyrophosphomevalonate decarboxylase [Central intermediary metabolism, Other]


Pssm-ID: 130307  Cd Length: 305  Bit Score: 349.63  E-value: 7.20e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981    5 GKARAHTNIALIKYWGKKDEALIIPMNNSISVTLEKFYTETKVTFNDQLTQDQFWLNGEKVSGKELEKISKYMDIVRNRA 84
Cdd:TIGR01240   1 ASVTAYVNIATIKYWGKRNTKLNLPTNSSISLTLSQLRTLTSVAFADEFERDTFYLNGTLQHSIDNEKTSNCLDDFRQLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981   85 GIDWYAEIESDNFVPTAAGLASSASAYAALAAACNQALDLQLSDKDLSRLARIGSGSASRSIYGGFAEWEKGYNDETSYA 164
Cdd:TIGR01240  81 KEQEKLHIVSQNNFPTAAGLASSASGLAALVSACAKLYQLPLDTSELSRIARKGSGSACRSLFGGYVAWEKGKDDHSSAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981  165 VPLESNHFEDDLAMIFVVINQHSKKVPSRYGMSLTRNTSRFYQYWLDHIDEDLAEAKAAIQDKDFKRLGEVIEENGLRMH 244
Cdd:TIGR01240 161 VQVADDSDWPQ*AMCVLVVNDIKKDVSSRQGMQLTVATSELFKEWIEHVVPDFEV*RKAIKTKDFATFGKETEANSLSMH 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446519981  245 ATNLGSTPPFTYLVQESYDVMALVHECREAGYPCYFTMDAGPNVKILVEKKNKQQIIDKLLTQF 308
Cdd:TIGR01240 241 ATTLDAFPPFFYLNDTSKRAMSAVHTLRQGGTICYFTMDAGPNVKVLYLAENLSKLFEFIYKLF 304
PLN02407 PLN02407
diphosphomevalonate decarboxylase
 7-308 6.55e-49

diphosphomevalonate decarboxylase


Pssm-ID: 178029  Cd Length: 343  Bit Score: 166.89  E-value: 6.55e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981   7 ARAHTNIALIKYWGKKDEALIIPMNNSISVTL--EKFYTETKVTFNDQLTQDQFWLNGEKVS--GKEL-----EKISKYM 77
Cdd:PLN02407   6 AQAPTNIAVIKYWGKRDEKLILPINSSISVTLdpDHLCATTTVAVSPSFDQDRLWLNGKEISlsGGRYqnclrEIRARAT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981  78 DIVRNRAGI-----DW---YAEIESDNFVPTAAGLASSASAYAALAAACNQALDLQLSDK-DLSRLARIGSGSASRSIYG 148
Cdd:PLN02407  86 DVEDEEKGIkitkkDWeklHVHIASYNNFPTAAGLASSAAGFACLVFALAKLMNVKEDFPgELSAIARQGSGSACRSLYG 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981 149 GFAEWEKGYNDE--TSYAVPLESNHFEDDLAMIFVVINQHSKKVPSRYGMSLTRNTSRFYQYWLDHI-DEDLAEAKAAIQ 225
Cdd:PLN02407 166 GFVKWNMGKKEDgsDSIAVQLADEKHWDDLVIIIAVVSSRQKETSSTSGMRESVETSPLLQHRAKEVvPKRILQMEEAIK 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981 226 DKDFKRLGEVIEENGLRMHATNLGSTPPFTYLVQESYDVMALVHEC-REAGYP-CYFTMDAGPN-VKILVEKKNKQQIID 302
Cdd:PLN02407 246 NRDFASFAKLTCADSNQFHATCLDTSPPIFYMNDTSRRIISLVEKWnRSEGTPqVAYTFDAGPNaVLIALNRKVAAQLLQ 325


                 ....*.
gi 446519981 303 KLLTQF 308
Cdd:PLN02407 326 RLLYYF 331
MDD_C pfam18376
Mevalonate 5-diphosphate decarboxylase C-terminal domain; Mevalonate diphosphate decarboxylase ...
 177-316 2.51e-18

Mevalonate 5-diphosphate decarboxylase C-terminal domain; Mevalonate diphosphate decarboxylase (EC:4.1.1.33) catalyzes the ATP dependent decarboxylation of mevalonate 5-diphosphate (MVAPP) to form isopentenyl 5-diphosphate. The reaction is required for production of polyisoprenoids and sterols from acetyl-CoA. This entry represents the C-terminal domain of the mevalonate 5-diphosphate decarboxylase enzyme which is a member of the GHMP kinase superfamily.


Pssm-ID: 465732  Cd Length: 186  Bit Score: 81.07  E-value: 2.51e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981  177 AMIFVVINQHsKKVPSRYGMSLTRNTSRFYQYWLDHI-DEDLAEAKAAIQDKDFKRLGEVIEENGLRMHATNLGSTPPFT 255
Cdd:pfam18376   1 VLILVVSDEK-KEVSSTSGMQRSVETSPLLKHRAEHVvPERMEAMEKAILAKDFETFAEITMKDSNQFHAVCLDTYPPIF 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446519981  256 YLVQESYDVMALVHE----CRE--AGYpcyfTMDAGPNVKILVEKKNKQQIIDKLLTQFDNNQIIDS 316
Cdd:pfam18376  80 YLNDTSRAIIQLVHAynefAGRikVAY----TFDAGPNAVLYLLEKDVPKVLSLLKHFFPPSTNGDQ 142
 
Name Accession Description Interval E-value
MVD1 COG3407
Mevalonate pyrophosphate decarboxylase [Lipid transport and metabolism]; Mevalonate ...
 1-325 7.34e-157

Mevalonate pyrophosphate decarboxylase [Lipid transport and metabolism]; Mevalonate pyrophosphate decarboxylase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 442633  Cd Length: 322  Bit Score: 441.55  E-value: 7.34e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981   1 MIKSGKARAHTNIALIKYWGKKDEALIIPMNNSISVTLEKFYTETKVTFNDQLTQDQFWLNGEKVSGKELEKISKYMDIV 80
Cdd:COG3407    2 AMGSATARAHSNIALIKYWGKRDEELNLPANPSLSLTLDAFYTTTTVEFDKDLAEDEFILNGEPQKGKFLPKISKFLDRV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981  81 RNRAGIDWYAEIESDNFVPTaaglassasayaalaaaCNQALDLQLSDKDLSRLARIGSGSASRSIYGGFAEWEKGYNDE 160
Cdd:COG3407   82 RALAGKSYHARIESENNFPTaaglassasgfaalalaANSAEGLDLDDRKLSRLARLGSGSACRSIFGGFVEWGKGEDDE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981 161 TSYAVPLESNHFedDLAMIFVVINQHSKKVPSRYGMSlTRNTSRFYQYWLDHIDEDLAEAKAAIQDKDFKRLGEVIEENG 240
Cdd:COG3407  162 DSYAVPIPAEDW--DLADIILVVDKGEKKVSSREGMK-TAETSPFYPAWVEQAEEDLEKLKEAIKAGDFEALGEIAESNA 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981 241 LRMHATNLGSTPPFTYLVQESYDVMALVHECREAGYPCYFTMDAGPNVKILVEKKNKQQIIDKLLTQFDNNQIIdSDIIA 320
Cdd:COG3407  239 LRMHATMMTSNPPFIYWKPNTLEVINAVRELREEGLPVYFTLDAGPNVKVLCPEEDAEKVAAFLAAELVNGQVI-VDKPG 317


                 ....*
gi 446519981 321 TGIEI 325
Cdd:COG3407  318 PGARL 322
mevDPdecarb TIGR01240
diphosphomevalonate decarboxylase; This enzyme catalyzes the last step in the synthesis of ...
 5-308 7.20e-121

diphosphomevalonate decarboxylase; This enzyme catalyzes the last step in the synthesis of isopentenyl diphosphate (IPP) in the mevalonate pathway. Alternate names: mevalonate diphosphate decarboxylase; pyrophosphomevalonate decarboxylase [Central intermediary metabolism, Other]


Pssm-ID: 130307  Cd Length: 305  Bit Score: 349.63  E-value: 7.20e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981    5 GKARAHTNIALIKYWGKKDEALIIPMNNSISVTLEKFYTETKVTFNDQLTQDQFWLNGEKVSGKELEKISKYMDIVRNRA 84
Cdd:TIGR01240   1 ASVTAYVNIATIKYWGKRNTKLNLPTNSSISLTLSQLRTLTSVAFADEFERDTFYLNGTLQHSIDNEKTSNCLDDFRQLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981   85 GIDWYAEIESDNFVPTAAGLASSASAYAALAAACNQALDLQLSDKDLSRLARIGSGSASRSIYGGFAEWEKGYNDETSYA 164
Cdd:TIGR01240  81 KEQEKLHIVSQNNFPTAAGLASSASGLAALVSACAKLYQLPLDTSELSRIARKGSGSACRSLFGGYVAWEKGKDDHSSAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981  165 VPLESNHFEDDLAMIFVVINQHSKKVPSRYGMSLTRNTSRFYQYWLDHIDEDLAEAKAAIQDKDFKRLGEVIEENGLRMH 244
Cdd:TIGR01240 161 VQVADDSDWPQ*AMCVLVVNDIKKDVSSRQGMQLTVATSELFKEWIEHVVPDFEV*RKAIKTKDFATFGKETEANSLSMH 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446519981  245 ATNLGSTPPFTYLVQESYDVMALVHECREAGYPCYFTMDAGPNVKILVEKKNKQQIIDKLLTQF 308
Cdd:TIGR01240 241 ATTLDAFPPFFYLNDTSKRAMSAVHTLRQGGTICYFTMDAGPNVKVLYLAENLSKLFEFIYKLF 304
PLN02407 PLN02407
diphosphomevalonate decarboxylase
 7-308 6.55e-49

diphosphomevalonate decarboxylase


Pssm-ID: 178029  Cd Length: 343  Bit Score: 166.89  E-value: 6.55e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981   7 ARAHTNIALIKYWGKKDEALIIPMNNSISVTL--EKFYTETKVTFNDQLTQDQFWLNGEKVS--GKEL-----EKISKYM 77
Cdd:PLN02407   6 AQAPTNIAVIKYWGKRDEKLILPINSSISVTLdpDHLCATTTVAVSPSFDQDRLWLNGKEISlsGGRYqnclrEIRARAT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981  78 DIVRNRAGI-----DW---YAEIESDNFVPTAAGLASSASAYAALAAACNQALDLQLSDK-DLSRLARIGSGSASRSIYG 148
Cdd:PLN02407  86 DVEDEEKGIkitkkDWeklHVHIASYNNFPTAAGLASSAAGFACLVFALAKLMNVKEDFPgELSAIARQGSGSACRSLYG 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981 149 GFAEWEKGYNDE--TSYAVPLESNHFEDDLAMIFVVINQHSKKVPSRYGMSLTRNTSRFYQYWLDHI-DEDLAEAKAAIQ 225
Cdd:PLN02407 166 GFVKWNMGKKEDgsDSIAVQLADEKHWDDLVIIIAVVSSRQKETSSTSGMRESVETSPLLQHRAKEVvPKRILQMEEAIK 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981 226 DKDFKRLGEVIEENGLRMHATNLGSTPPFTYLVQESYDVMALVHEC-REAGYP-CYFTMDAGPN-VKILVEKKNKQQIID 302
Cdd:PLN02407 246 NRDFASFAKLTCADSNQFHATCLDTSPPIFYMNDTSRRIISLVEKWnRSEGTPqVAYTFDAGPNaVLIALNRKVAAQLLQ 325


                 ....*.
gi 446519981 303 KLLTQF 308
Cdd:PLN02407 326 RLLYYF 331
MDD_C pfam18376
Mevalonate 5-diphosphate decarboxylase C-terminal domain; Mevalonate diphosphate decarboxylase ...
 177-316 2.51e-18

Mevalonate 5-diphosphate decarboxylase C-terminal domain; Mevalonate diphosphate decarboxylase (EC:4.1.1.33) catalyzes the ATP dependent decarboxylation of mevalonate 5-diphosphate (MVAPP) to form isopentenyl 5-diphosphate. The reaction is required for production of polyisoprenoids and sterols from acetyl-CoA. This entry represents the C-terminal domain of the mevalonate 5-diphosphate decarboxylase enzyme which is a member of the GHMP kinase superfamily.


Pssm-ID: 465732  Cd Length: 186  Bit Score: 81.07  E-value: 2.51e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446519981  177 AMIFVVINQHsKKVPSRYGMSLTRNTSRFYQYWLDHI-DEDLAEAKAAIQDKDFKRLGEVIEENGLRMHATNLGSTPPFT 255
Cdd:pfam18376   1 VLILVVSDEK-KEVSSTSGMQRSVETSPLLKHRAEHVvPERMEAMEKAILAKDFETFAEITMKDSNQFHAVCLDTYPPIF 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446519981  256 YLVQESYDVMALVHE----CRE--AGYpcyfTMDAGPNVKILVEKKNKQQIIDKLLTQFDNNQIIDS 316
Cdd:pfam18376  80 YLNDTSRAIIQLVHAynefAGRikVAY----TFDAGPNAVLYLLEKDVPKVLSLLKHFFPPSTNGDQ 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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