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Conserved domains on  [gi|446506981|ref|WP_000584759|]
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MULTISPECIES: staphylopine uptake ABC transporter permease subunit CntC [Staphylococcus]

Protein Classification

ABC transporter permease( domain architecture ID 11439449)

ABC transporter permease is the transmembrane (TM) subunit in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which generally binds a type 2 PBP; similar to the permease subunit of ABC-type dipeptide/oligopeptide/nickel transport systems

Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 3-270 2.29e-93

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


:

Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 276.99  E-value: 2.29e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981   3 ILKRLLQDKGAVIALGIIVLYVFLGLAAPLVTFYDPNHIDTANKFAGISFQHLLGTDHLGRDILTRLIYAIRPSLLYVFV 82
Cdd:COG1173    8 AWRRLRRNPLAVIGLVILLLLVLLALFAPLLAPYDPTAQDLAARLQPPSAAHWLGTDQLGRDVLSRLLYGARISLLVGLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981  83 ALFVSVLIGSILGFLSGYFQGFVDALIMRACDVMLAFPSYVVTLALIALFGMGAENIIMAFILTRWAWFCRVIRTSVMQY 162
Cdd:COG1173   88 AVLIALVIGVLLGLLAGYFGGWVDAVLMRLVDVLLAFPSLLLAIALVAVLGPGLLNVILALGLTGWPGYARLVRAQVLSL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981 163 TASDHVRFAKTIGMNDMKIIHKHIMPLTLADIAIISSSSMCSMILQISGFSFLGLGVKAPTAEWGMMLNEARKVMFTHPE 242
Cdd:COG1173  168 REREYVEAARALGASPLRIIFRHILPNVLPPLIVQATLGIASAILAEAGLSFLGLGVQPPTPSWGTMLSEGRNYLLTAPW 247

                        250       260
                 ....*....|....*....|....*...
gi 446506981 243 MMFAPGIAIVIIVMAFNFLSDALQIAID 270
Cdd:COG1173  248 LALFPGLAIVLTVLAFNLLGDGLRDALD 275
 
Name Accession Description Interval E-value
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 3-270 2.29e-93

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 276.99  E-value: 2.29e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981   3 ILKRLLQDKGAVIALGIIVLYVFLGLAAPLVTFYDPNHIDTANKFAGISFQHLLGTDHLGRDILTRLIYAIRPSLLYVFV 82
Cdd:COG1173    8 AWRRLRRNPLAVIGLVILLLLVLLALFAPLLAPYDPTAQDLAARLQPPSAAHWLGTDQLGRDVLSRLLYGARISLLVGLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981  83 ALFVSVLIGSILGFLSGYFQGFVDALIMRACDVMLAFPSYVVTLALIALFGMGAENIIMAFILTRWAWFCRVIRTSVMQY 162
Cdd:COG1173   88 AVLIALVIGVLLGLLAGYFGGWVDAVLMRLVDVLLAFPSLLLAIALVAVLGPGLLNVILALGLTGWPGYARLVRAQVLSL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981 163 TASDHVRFAKTIGMNDMKIIHKHIMPLTLADIAIISSSSMCSMILQISGFSFLGLGVKAPTAEWGMMLNEARKVMFTHPE 242
Cdd:COG1173  168 REREYVEAARALGASPLRIIFRHILPNVLPPLIVQATLGIASAILAEAGLSFLGLGVQPPTPSWGTMLSEGRNYLLTAPW 247

                        250       260
                 ....*....|....*....|....*...
gi 446506981 243 MMFAPGIAIVIIVMAFNFLSDALQIAID 270
Cdd:COG1173  248 LALFPGLAIVLTVLAFNLLGDGLRDALD 275
nickel_nikC TIGR02790
nickel ABC transporter, permease subunit NikC; This family consists of the NikC family of ...
 13-270 1.28e-78

nickel ABC transporter, permease subunit NikC; This family consists of the NikC family of nickel ABC transporter permeases. Operons that contain this protein also contain a homologous permease subunit NikB. Nickel is used in cells as part of urease or certain hydrogenases or superoxide dismutases. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 131837 [Multi-domain]  Cd Length: 258  Bit Score: 239.21  E-value: 1.28e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981   13 AVIALGIIVLYVFLGLAAPLVTFYDPNHIDTANKFAGISFQHLLGTDHLGRDILTRLIYAIRPSLLYVFVALFVSVLIGS 92
Cdd:TIGR02790   1 VVSALLIIAVLFLLAIFAPWIAPHDPLAQNLPMRLLGPSMEYWLGTDHLGRCIFSRLIFGARVSLGSALLVLGLVLTIGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981   93 ILGFLSGYFQGFVDALIMRACDVMLAFPSYVVTLALIALFGMGAENIIMAFILTRWAWFCRVIRTSVMQYTASDHVRFAK 172
Cdd:TIGR02790  81 LIGGLAGYIGGRVDEAIMRVCDVFLSFPTIILSLAIVGILGPGLENVIIAIVLVHWAWYARMVRGMVVSLKQREFVLAAR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981  173 TIGMNDMKIIHKHIMPLTLADIAIISSSSMCSMILQISGFSFLGLGVKAPTAEWGMMLNEARKVMFTHPEMMFAPGIAIV 252
Cdd:TIGR02790 161 TSGASHWQIIRRHILPNILSPIIVLATLDIGHVILHIAGLSFLGLGIQPPTPEWGAMLSEAKQYIWTQPLLMIYPGLAIL 240

                         250
                  ....*....|....*...
gi 446506981  253 IIVMAFNFLSDALQIAID 270
Cdd:TIGR02790 241 ISVMAFNLLGDALRDHLG 258
nikC PRK10417
nickel transporter permease NikC; Provisional
 15-271 3.79e-73

nickel transporter permease NikC; Provisional


Pssm-ID: 236687 [Multi-domain]  Cd Length: 272  Bit Score: 225.70  E-value: 3.79e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981  15 IALGIIVLYVFLGLAAPLVTFYDPNHIDTANKFAGISFQHLLGTDHLGRDILTRLIYAIRPSLLYVFVALFVSVLIGSIL 94
Cdd:PRK10417   8 LALIIIALLALIALTSQWWLPYDPQAIDLPSRLLSPDAQHWLGTDHLGRDIFSRLMAGTRVSLGSVMACLLLVLALGLVI 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981  95 GFLSGYFQGFVDALIMRACDVMLAFPSYVVTLALIALFGMGAENIIMAFILTRWAWFCRVIRTSVMQYTASDHVRFAKTI 174
Cdd:PRK10417  88 GGSAGLLGGRVDQATMRVADMFMTFPTSILAFFMVGVLGTGLTNVIIAIALSHWAWYARMVRSLVISLRQREFVLAARLS 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981 175 GMNDMKIIHKHIMPLTLADIAIISSSSMCSMILQISGFSFLGLGVKAPTAEWGMMLNEARKVMFTHPEMMFAPGIAIVII 254
Cdd:PRK10417 168 GAGHVRVFIDHLLPAVIPQLLVLATLDIGHMMLHVAGLSFLGLGVTAPTAEWGVMINDARQYIWTQPLLMFWPGLALFIS 247

                        250
                 ....*....|....*..
gi 446506981 255 VMAFNFLSDALQIAIDP 271
Cdd:PRK10417 248 VMAFNLLGDALRDHLDP 264
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 73-258 4.09e-11

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 60.76  E-value: 4.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981  73 IRPSLLYVFVALFVSVLIGSILGFLSGYFQGFVDALIMRACDVMLAFPSYVVTLALIALFGMGAE--------NIIMAFI 144
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGwgilpglgLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981 145 LTRWAWFCRVIRTSVMQYTASDHVRFAKTIGMNDMKIIHKHIMPLTLADIAIISSSSMCSMILQISGFSFLGLGVkAPTA 224
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGE-APGP 159

                        170       180       190
                 ....*....|....*....|....*....|....
gi 446506981 225 EWGMMLNEARKVMFThpeMMFAPGIAIVIIVMAF 258
Cdd:cd06261  160 GTGLLLIFAILFPGD---LGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 87-274 1.81e-10

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 58.85  E-value: 1.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981   87 SVLIGSILGFLSGyfqGFVDALIMRACDVMLAFPSYVVTLALIALFGM-----GAENIIMAFILTrWAWFCRVIRTSVMQ 161
Cdd:pfam00528   1 GIPLGIIAALRRG---RRLDRLLRPLIDLLQALPSFVLAILLVVIAILsilghGILPAIILALLG-WAGYARLIRRAALR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981  162 YTASDHVRFAKTIGMNDMKIIHKHIMPLTLADIAIISSSSMCSMILQISGFSFL----GLGVKAPTAEWGMMLNearkvm 237
Cdd:pfam00528  77 SLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLgswpGLGLLLIEAILGYDYP------ 150

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 446506981  238 fthpeMMFAPGIAIVIIVMAFNFLSDALQIAIDPRIS 274
Cdd:pfam00528 151 -----EIQGPVLAAALILLLLNLLVDILQRLLDPRVR 182
 
Name Accession Description Interval E-value
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 3-270 2.29e-93

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 276.99  E-value: 2.29e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981   3 ILKRLLQDKGAVIALGIIVLYVFLGLAAPLVTFYDPNHIDTANKFAGISFQHLLGTDHLGRDILTRLIYAIRPSLLYVFV 82
Cdd:COG1173    8 AWRRLRRNPLAVIGLVILLLLVLLALFAPLLAPYDPTAQDLAARLQPPSAAHWLGTDQLGRDVLSRLLYGARISLLVGLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981  83 ALFVSVLIGSILGFLSGYFQGFVDALIMRACDVMLAFPSYVVTLALIALFGMGAENIIMAFILTRWAWFCRVIRTSVMQY 162
Cdd:COG1173   88 AVLIALVIGVLLGLLAGYFGGWVDAVLMRLVDVLLAFPSLLLAIALVAVLGPGLLNVILALGLTGWPGYARLVRAQVLSL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981 163 TASDHVRFAKTIGMNDMKIIHKHIMPLTLADIAIISSSSMCSMILQISGFSFLGLGVKAPTAEWGMMLNEARKVMFTHPE 242
Cdd:COG1173  168 REREYVEAARALGASPLRIIFRHILPNVLPPLIVQATLGIASAILAEAGLSFLGLGVQPPTPSWGTMLSEGRNYLLTAPW 247

                        250       260
                 ....*....|....*....|....*...
gi 446506981 243 MMFAPGIAIVIIVMAFNFLSDALQIAID 270
Cdd:COG1173  248 LALFPGLAIVLTVLAFNLLGDGLRDALD 275
nickel_nikC TIGR02790
nickel ABC transporter, permease subunit NikC; This family consists of the NikC family of ...
 13-270 1.28e-78

nickel ABC transporter, permease subunit NikC; This family consists of the NikC family of nickel ABC transporter permeases. Operons that contain this protein also contain a homologous permease subunit NikB. Nickel is used in cells as part of urease or certain hydrogenases or superoxide dismutases. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 131837 [Multi-domain]  Cd Length: 258  Bit Score: 239.21  E-value: 1.28e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981   13 AVIALGIIVLYVFLGLAAPLVTFYDPNHIDTANKFAGISFQHLLGTDHLGRDILTRLIYAIRPSLLYVFVALFVSVLIGS 92
Cdd:TIGR02790   1 VVSALLIIAVLFLLAIFAPWIAPHDPLAQNLPMRLLGPSMEYWLGTDHLGRCIFSRLIFGARVSLGSALLVLGLVLTIGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981   93 ILGFLSGYFQGFVDALIMRACDVMLAFPSYVVTLALIALFGMGAENIIMAFILTRWAWFCRVIRTSVMQYTASDHVRFAK 172
Cdd:TIGR02790  81 LIGGLAGYIGGRVDEAIMRVCDVFLSFPTIILSLAIVGILGPGLENVIIAIVLVHWAWYARMVRGMVVSLKQREFVLAAR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981  173 TIGMNDMKIIHKHIMPLTLADIAIISSSSMCSMILQISGFSFLGLGVKAPTAEWGMMLNEARKVMFTHPEMMFAPGIAIV 252
Cdd:TIGR02790 161 TSGASHWQIIRRHILPNILSPIIVLATLDIGHVILHIAGLSFLGLGIQPPTPEWGAMLSEAKQYIWTQPLLMIYPGLAIL 240

                         250
                  ....*....|....*...
gi 446506981  253 IIVMAFNFLSDALQIAID 270
Cdd:TIGR02790 241 ISVMAFNLLGDALRDHLG 258
nikC PRK10417
nickel transporter permease NikC; Provisional
 15-271 3.79e-73

nickel transporter permease NikC; Provisional


Pssm-ID: 236687 [Multi-domain]  Cd Length: 272  Bit Score: 225.70  E-value: 3.79e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981  15 IALGIIVLYVFLGLAAPLVTFYDPNHIDTANKFAGISFQHLLGTDHLGRDILTRLIYAIRPSLLYVFVALFVSVLIGSIL 94
Cdd:PRK10417   8 LALIIIALLALIALTSQWWLPYDPQAIDLPSRLLSPDAQHWLGTDHLGRDIFSRLMAGTRVSLGSVMACLLLVLALGLVI 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981  95 GFLSGYFQGFVDALIMRACDVMLAFPSYVVTLALIALFGMGAENIIMAFILTRWAWFCRVIRTSVMQYTASDHVRFAKTI 174
Cdd:PRK10417  88 GGSAGLLGGRVDQATMRVADMFMTFPTSILAFFMVGVLGTGLTNVIIAIALSHWAWYARMVRSLVISLRQREFVLAARLS 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981 175 GMNDMKIIHKHIMPLTLADIAIISSSSMCSMILQISGFSFLGLGVKAPTAEWGMMLNEARKVMFTHPEMMFAPGIAIVII 254
Cdd:PRK10417 168 GAGHVRVFIDHLLPAVIPQLLVLATLDIGHMMLHVAGLSFLGLGVTAPTAEWGVMINDARQYIWTQPLLMFWPGLALFIS 247

                        250
                 ....*....|....*..
gi 446506981 255 VMAFNFLSDALQIAIDP 271
Cdd:PRK10417 248 VMAFNLLGDALRDHLDP 264
PRK15082 PRK15082
glutathione ABC transporter permease GsiD; Provisional
 5-273 1.35e-58

glutathione ABC transporter permease GsiD; Provisional


Pssm-ID: 185040 [Multi-domain]  Cd Length: 301  Bit Score: 189.17  E-value: 1.35e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981   5 KRLLQDKGAVIALGIIVLYVFLGLAAPLVTFYDP-NHIDTANKFAGISFQHLLGTDHLGRDILTRLIYAIRPSLLYVFVA 83
Cdd:PRK15082  30 RRFRRQHVALVAGLFVLLLIVVAIFAPWIAPYDAeNYFDYDALNAGPSLQHWFGVDSLGRDIFSRILVGARISLAAGFFS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981  84 LFVSVLIGSILGFLSGYFQGFVDALIMRACDVMLAFPSYVVTLALIALFGMGAENIIMAFILTRWAWFCRVIRTSVMQYT 163
Cdd:PRK15082 110 VAIGAAIGTVLGLLAGYYEGWWDRIIMRICDVLFAFPGILLAIAVVAILGSGMANVIIAVAIFSIPAFARLVRGNTLVLK 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981 164 ASDHVRFAKTIGMNDMKIIHKHIMPLTLADIAIISSSSMCSMILQISGFSFLGLGVKAPTAEWGMMLNEARKVMFTHPEM 243
Cdd:PRK15082 190 QQTYIESARSIGASDWTILLRHILPGTVSSIVVYFTMRIGTSIITAASLSFLGLGAQPPTPEWGAMLNEARADMVIAPHV 269

                        250       260       270
                 ....*....|....*....|....*....|
gi 446506981 244 MFAPGIAIVIIVMAFNFLSDALQIAIDPRI 273
Cdd:PRK15082 270 ALFPSLAIFLTVLAFNLLGDGLRDALDPKI 299
PRK09881 PRK09881
D,D-dipeptide ABC transporter permease;
6-276 1.54e-47

D,D-dipeptide ABC transporter permease;


Pssm-ID: 182131 [Multi-domain]  Cd Length: 296  Bit Score: 160.75  E-value: 1.54e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981   6 RLLQDKGAVIALGIIVLYVFLGLAAPLVTFYDPNHIDTANKFAGISFQHLLGTDHLGRDILTRLIYAIRPSLLYVFVALF 85
Cdd:PRK09881  26 MLKGSPLTVTGAVIIVLMLLMMIFSPWLATHDPNAIDLTARLLPPSAAHWFGTDEVGRDLFSRVLVGSQQSILAGLVVVA 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981  86 VSVLIGSILGFLSGYFQGFVDALIMRACDVMLAFPSYVVTLALIALFGMGAENIIMAFILTRWAWFCRVIRTSVMQYTAS 165
Cdd:PRK09881 106 IAGMIGSLLGCLSGVLGGRADAIIMRIMDIMLSIPSLVLTMALAAALGPSLFNAMLAIAIVRIPFYVRLARGQALVVRQY 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981 166 DHVRFAKTIGMNDMKIIHKHIMPLTLADIAIISSSSMCSMILQISGFSFLGLGVKAPTAEWGMMLNEARKVMFTHPEMMF 245
Cdd:PRK09881 186 TYVQAAKTFGASRWHLISWHILRNSLPPLIVQASLDIGSAILMAATLGFIGLGAQQPSAEWGAMVANGRNYVLDQWWYCA 265

                        250       260       270
                 ....*....|....*....|....*....|.
gi 446506981 246 APGIAIVIIVMAFNFLSDALQIAIDPRISSK 276
Cdd:PRK09881 266 FPGAAILLTAVGFNLFGDGIRDLLDPKAGGK 296
PRK10913 PRK10913
dipeptide ABC transporter permease DppC;
9-273 2.27e-46

dipeptide ABC transporter permease DppC;


Pssm-ID: 182833 [Multi-domain]  Cd Length: 300  Bit Score: 157.64  E-value: 2.27e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981   9 QDKGAVIALGIIVLYVFLGLAAPLVTFYDPnhidtANKF-----------AGISFQHLLGTDHLGRDILTRLIYAIRPSL 77
Cdd:PRK10913  28 RNKGAVVGLVYVVIMLFIAIFANWIAPHNP-----AEQFrdallappvwqEGGSWAHILGTDDVGRDVLSRLMYGARLSL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981  78 LYVFVALFVSVLIGSILGFLSGYFQGFVDALIMRACDVMLAFPSYVVTLALIALFGMGAENIIMAFILTRWAWFCRVIRT 157
Cdd:PRK10913 103 LVGCLVVVLSLVMGVILGLIAGYFGGLVDNIIMRVVDIMLALPSLLLALVLVAIFGPSIVNAALALTFVALPHYVRLTRA 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981 158 SVMQYTASDHVRFAKTIGMNDMKIIHKHIMPLTLADIAIISSSSMCSMILQISGFSFLGLGVKAPTAEWGMMLNEARKVM 237
Cdd:PRK10913 183 AVLVEVNRDYVTASRVAGAGAMRQMFINILPNCLAPLIVQASLGFSNAILDMAALGFLGMGAQPPTPEWGTMLSDVLQFA 262

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 446506981 238 FTHPEMMFAPGIAIVIIVMAFNFLSDALQIAIDPRI 273
Cdd:PRK10913 263 QSAWWVVTFPGLAILLTVLAFNLMGDGLRDALDPKL 298
SapC COG4171
ABC-type antimicrobial peptide export system, permease component SapC [Defense mechanisms];
3-273 4.39e-38

ABC-type antimicrobial peptide export system, permease component SapC [Defense mechanisms];


Pssm-ID: 443331 [Multi-domain]  Cd Length: 296  Bit Score: 135.71  E-value: 4.39e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981   3 ILKRLLQDKGAVIALGIIVLYVFLGLAAPLVTFYDPNHidtanKFAGI-----------SFQHLLGTDHLGRDILTRLIY 71
Cdd:COG4171   19 IWQSFRKNPLAMIGLYGFLFLILLALFGPLLAPYSPDQ-----QFIGAlllppswddngDVSFFLGTDDLGRDILSRLLY 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981  72 AIRPSLLYVFVALFVSVLIGSILGFLSGYFQGFVDALIMRACDVMLAFPSYVVTLALIALFGMGAENIIMAFILTRWAWF 151
Cdd:COG4171   94 GARYTFGSALLVVLAAAIIGGIIGILAGMSRGLKSSILNHLLDTLLSIPSLLLAIIIVALLGPGLENAMLAITLALLPQF 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981 152 CRVIRTSVMQYTASDHVRFAKTIGMNDMKIIHKHIMPLTLADIAIISSSSMCSMILQISGFSFLGLGVKAPTAEWGMMLN 231
Cdd:COG4171  174 IHAIYQAVHQELKKEYVLAARLDGASNWQLLRYSILPNILEVLVTELTRALSIAILDISALGFLGLGAQLPSPEWGAMLG 253

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 446506981 232 EARKVMFTHPEMMFAPGIAIVIIVMAFNFLSDALQIAIDPRI 273
Cdd:COG4171  254 DSLELIYLAPWTVILPGLAIMFSVLIVNLVGDGLRRALNKGV 295
PRK15406 PRK15406
oligopeptide ABC transporter permease OppC; Provisional
 5-272 2.04e-31

oligopeptide ABC transporter permease OppC; Provisional


Pssm-ID: 185304 [Multi-domain]  Cd Length: 302  Bit Score: 118.40  E-value: 2.04e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981   5 KRLLQDKGAVIALGIIVLYVFLGLAAPLVTFYDPNHIDTANKFAG--ISFQHLLGTDHLGRDILTRLIYAIRPSLLYVFV 82
Cdd:PRK15406  31 RRFMHNRAAVASLIVLVLIALFVILAPMLSQFAYDDTDWGMMSSApdMESGHYFGTDSSGRDLLVRVAIGGRISLMVGVA 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981  83 ALFVSVLIGSILGFLSGYFQGFVDALIMRACDVMLAFPSYVVTLALIALFGMGAENIIMAFILTRWAWFCRVIRTSVMQY 162
Cdd:PRK15406 111 AALVAVVVGTLYGSLSGYLGGKVDSVMMRLLEILNSFPFMFFVILLVTFFGQNILLIFVAIGMVSWLDMARIVRGQTLSL 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981 163 TASDHVRFAKTIGMNDMKIIHKHIMPLTLADIAIISSSSMCSMILQISGFSFLGLGVKAPTAEWGMMLNEARKVMFTHPE 242
Cdd:PRK15406 191 KRKEFIEAAQVGGVSTRGIVLRHIVPNVLGVVVVYASLLVPSMILFESFLSFLGLGTQEPLSSWGALLSDGANSMEVSPW 270

                        250       260       270
                 ....*....|....*....|....*....|
gi 446506981 243 MMFAPGIAIVIIVMAFNFLSDALQIAIDPR 272
Cdd:PRK15406 271 LLLFPAGFLVVTLFCFNFIGDGLRDALDPK 300
YejE COG4239
ABC-type microcin C transport system, permease component YejE [Secondary metabolites ...
 38-272 8.48e-24

ABC-type microcin C transport system, permease component YejE [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443381 [Multi-domain]  Cd Length: 342  Bit Score: 98.68  E-value: 8.48e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981  38 PNHIDTANKFAGI------SFQHLLGTDHLGRDILTRLIYAIRPSLLYVFVALFVSVLIGSILGFLSGYFQGFVDALIMR 111
Cdd:COG4239   99 PYSYDTINYDLPSpapsppSAENWLGTDDQGRDVLARLIYGFRISVLFGLALTVISSVIGVAAGAVQGYFGGRVDLLFQR 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981 112 ACDVMLAFPSYVVTLALIALFGMGAENIIMAFILTRWAWFCRVIRTSVMQYTASDHVRFAKTIGMNDMKIIHKHIMPLTL 191
Cdd:COG4239  179 FIEIWSSMPELYLLIILSSIFQPSFWLLLGILLLFGWMGLVGVVRAEFLRARNLEYVRAARALGVSDRRIMFRHILPNAM 258

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981 192 ADIAIISSSSMCSMILQISGFSFLGLGVKAPTAEWGMMLNEARKVMfTHPEMMFAPGIAIVIIVMAFNFLSDALQIAIDP 271
Cdd:COG4239  259 VATLTFLPFILSGAITTLTSLDFLGFGLPPGSPSLGELLAQGKNNL-QAPWLGLSAFVVLALMLSLLVFIGEAVRDAFDP 337


                 .
gi 446506981 272 R 272
Cdd:COG4239  338 R 338
PRK15111 PRK15111
peptide ABC transporter permease SapC;
16-270 1.28e-22

peptide ABC transporter permease SapC;


Pssm-ID: 185066 [Multi-domain]  Cd Length: 296  Bit Score: 94.77  E-value: 1.28e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981  16 ALGIIVLYVFLGLAAPLV--TFYDPNHID-----------TANKFAGISFqhLLGTDHLGRDILTRLIYAIRPSLLYVFV 82
Cdd:PRK15111  27 ALAMVGLYGCAGLALLCLfgGWLAPYGIDqqflgyqllppSWSRYGEVSF--FLGTDDLGRDVLSRLLSGAAPTVGGAFV 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981  83 ALFVSVLIGSILGFLSGYFQGFVDALIMRACDVMLAFPSYVVTLALIALFGMGAENIIMAFILTRWAWFCRVIRTSVMQY 162
Cdd:PRK15111 105 VTLAATLCGLVLGVFAGATHGLRSAVLNHILDTLLSIPSLLLAIIVVAFAGPSLSHAMFAVWLALLPRMVRSIYSAVHDE 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981 163 TASDHVRFAKTIGMNDMKIIHKHIMPLTLADIAIISSSSMCSMILQISGFSFLGLGVKAPTAEWGMMLNEARKVMFTHPE 242
Cdd:PRK15111 185 LEKEYVIAARLDGASTLNILWYAVLPNITAGLVTEITRALSMAILDIAALGFLDLGAQLPSPEWGAMLGDSLELIYVAPW 264

                        250       260
                 ....*....|....*....|....*...
gi 446506981 243 MMFAPGIAIVIIVMAFNFLSDALQIAID 270
Cdd:PRK15111 265 TVMLPGAAIMLSVLLVNLLGDGIRRAII 292
PRK15021 PRK15021
microcin C ABC transporter permease; Provisional
 51-271 7.18e-18

microcin C ABC transporter permease; Provisional


Pssm-ID: 184982 [Multi-domain]  Cd Length: 341  Bit Score: 82.34  E-value: 7.18e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981  51 SFQHLLGTDHLGRDILTRLIYAIRPSLLYVFVALFVSVLIGSILGFLSGYFQGFVDALIMRACDVMLAFPSYVVTLALIA 130
Cdd:PRK15021 118 SRQNWLGTDANGGDVLARILYGTRISVLFGLMLTLCSSVMGVLAGALQGYYGGKVDLWGQRFIEVWSGMPTLFLIILLSS 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981 131 LFGMGAENIIMAFILTRWAWFCRVIRTSVMQYTASDHVRFAKTIGMNDMKIIHKHIMPLTLADIAIISSSSMCSMILQIS 210
Cdd:PRK15021 198 VVQPNFWWLLAITVLFGWMSLVGVVRAEFLRTRNFDYIRAAQALGVSDRSIILRHMLPNAMVATLTFLPFILCSSITTLT 277

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446506981 211 GFSFLGLGVKAPTAEWGMMLNEARKVMfTHPEMMFAPGIAIVIIVMAFNFLSDALQIAIDP 271
Cdd:PRK15021 278 SLDFLGFGLPLGSPSLGELLLQGKNNL-QAPWLGITAFLSVAILLSLLIFIGEAVRDAFDP 337
DppB COG0601
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 49-273 1.23e-12

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440366 [Multi-domain]  Cd Length: 314  Bit Score: 67.01  E-value: 1.23e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981  49 GISFQHllgtdhlGRDILTRLIYAIRPSLLYVFVALFVSVLIGSILGFLSGYFQG-FVDALIMRACDVMLAFPSYVVTLA 127
Cdd:COG0601   78 GTSFVY-------GRPVSDLIAERLPVTLELALLALLLALLIGIPLGILAALRRGsWLDRLITVLALLGISIPSFWLGLL 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981 128 LIALFG--------MGAENIIMAFI--------------LTRWAWFCRVIRTSVMQYTASDHVRFAKTIGMNDMKIIHKH 185
Cdd:COG0601  151 LILLFAvklgwlpvSGRVSPWEDFLdalrhlilpaltlaLGSLAGIARLTRSSMLEVLGQDYVRTARAKGLSERRVLLRH 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981 186 IMPLTLadiaiissssmcsmilqISGFSFLGLGVkaptaewGMMLNEArkvMFThpEMMFA-PGIA-------------- 250
Cdd:COG0601  231 ALRNAL-----------------IPVVTVLGLQL-------GGLLGGA---VVV--ETVFSwPGLGrllvdailnrdypv 281

                        250       260       270
                 ....*....|....*....|....*....|
gi 446506981 251 -------IVIIVMAFNFLSDALQIAIDPRI 273
Cdd:COG0601  282 vqgivllIAVLVVLVNLLVDLLYALLDPRI 311
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 73-258 4.09e-11

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 60.76  E-value: 4.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981  73 IRPSLLYVFVALFVSVLIGSILGFLSGYFQGFVDALIMRACDVMLAFPSYVVTLALIALFGMGAE--------NIIMAFI 144
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGwgilpglgLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981 145 LTRWAWFCRVIRTSVMQYTASDHVRFAKTIGMNDMKIIHKHIMPLTLADIAIISSSSMCSMILQISGFSFLGLGVkAPTA 224
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGE-APGP 159

                        170       180       190
                 ....*....|....*....|....*....|....
gi 446506981 225 EWGMMLNEARKVMFThpeMMFAPGIAIVIIVMAF 258
Cdd:cd06261  160 GTGLLLIFAILFPGD---LGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 87-274 1.81e-10

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 58.85  E-value: 1.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981   87 SVLIGSILGFLSGyfqGFVDALIMRACDVMLAFPSYVVTLALIALFGM-----GAENIIMAFILTrWAWFCRVIRTSVMQ 161
Cdd:pfam00528   1 GIPLGIIAALRRG---RRLDRLLRPLIDLLQALPSFVLAILLVVIAILsilghGILPAIILALLG-WAGYARLIRRAALR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446506981  162 YTASDHVRFAKTIGMNDMKIIHKHIMPLTLADIAIISSSSMCSMILQISGFSFL----GLGVKAPTAEWGMMLNearkvm 237
Cdd:pfam00528  77 SLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLgswpGLGLLLIEAILGYDYP------ 150

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 446506981  238 fthpeMMFAPGIAIVIIVMAFNFLSDALQIAIDPRIS 274
Cdd:pfam00528 151 -----EIQGPVLAAALILLLLNLLVDILQRLLDPRVR 182
OppC_N pfam12911
N-terminal TM domain of oligopeptide transport permease C; Oligopeptide permeases (Opp) have ...
 3-49 4.09e-05

N-terminal TM domain of oligopeptide transport permease C; Oligopeptide permeases (Opp) have been identified in numerous gram-negative and -positive bacteria. These transport systems belong to the superfamily of highly conserved ATP-binding cassette transporters. Typically, Opp importers comprise a complex of five proteins. The oligopeptide-binding protein OppA is responsible for the capture of peptides from the external medium. Two integral highly hydrophobic membrane spanning proteins, OppB and OppC, form a channel through the membrane used for peptide translocation. This N-terminal domain appears to be the first TM domain of the molecule.


Pssm-ID: 463747 [Multi-domain]  Cd Length: 53  Bit Score: 40.47  E-value: 4.09e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 446506981    3 ILKRLLQDKGAVIALGIIVLYVFLGLAAPLVTFYDPNHIDTANKFAG 49
Cdd:pfam12911   6 AWRRFRRNKLAMVGLVILLLLVLLAIFAPLLAPYDPDQQDLSADLLP 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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