NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446504336|ref|WP_000582190|]
View 

MULTISPECIES: phage tail spike protein [Staphylococcus]

Protein Classification

CHAP domain-containing protein; SGNH/GDSL hydrolase family protein( domain architecture ID 10019769)

cysteine, histidine-dependent amidohydrolase/peptidase (CHAP) domain-containing protein may function as an amidase involved in the cleavage of peptidoglycan| SGNH/GDSL hydrolase family protein is a hydrolytic enzyme such as an esterase or lipase; may have multifunctional properties including broad substrate specificity and regiospecificity

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
put_anti_recept TIGR01665
phage minor structural protein, N-terminal region; This model represents the conserved ...
 24-337 2.68e-82

phage minor structural protein, N-terminal region; This model represents the conserved N-terminal region, typically from about residue 25 to about residue 350, of a family of uncharacterized phage proteins 500 to 1700 residues in length. [Mobile and extrachromosomal element functions, Prophage functions]


:

Pssm-ID: 273743 [Multi-domain]  Cd Length: 317  Bit Score: 272.36  E-value: 2.68e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336    24 RAIHKRNVNDNSEMLELLISSE--RAEKFRKRHRVIIRDSN-KQWREFIINWVQDTmDGYTEIECIASYLADITTAKPYA 100
Cdd:TIGR01665    1 KDIKISEEKNNLDTLTFSLPFDdpLWEKIKEENYIKKHDDDlKNEQLFRINNVSED-ASDDSISVEAIHVAVDLLDHVII 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336   101 PGKFEKKTTSEALKDVLSDTgWEVSEQTEYDGLRTTSWTSYQTRYEVLKQLCTTYKMVLdFYIELSSNTVKGRYVVLKKK 180
Cdd:TIGR01665   80 PIKREKNTTSAALERLAKTT-WEVWKLGECSDIKTISITFYQTSRNALQAIAKLYKLSI-FYQWGGDNTITGKIVNLYKK 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336   181 NSLFKGKEIEYGKDLVGLTRKIDMSEIKTALIAVGPEN--DKGKRLELVVTDDEAQSQFnlPMRYIWGIYEPQSDDQNMN 258
Cdd:TIGR01665  158 IGSETGKEFEYGKNLVGLNRKEDTKNIVTRLIPFGKGEggEKGLTIESSNVGDEYIVDK--DRQYKPNVDTTWVDGRYTD 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336   259 ETRLSSLAKTELNKRK--SAVMSYEITSTDLEVTYP---HEIISIGDTVRVKHRDFNPPLYveAEVIAEEYNIISENSTY 333
Cdd:TIGR01665  236 ETTLRAYAKQKLMTLKkdMPKVSYEVTVADLENLSEyksLEPIGIGDTVRLKHTDFNIKVY--ARVIKVEYSPVTPKQNS 313


                   ....
gi 446504336   334 TFGQ 337
Cdd:TIGR01665  314 IEFG 317
HEC1 super family cl34933
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 493-850 1.32e-07

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG5185:

Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 56.12  E-value: 1.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  493 YNQIKNNLESMTPETATIGRLVDTKTLFLEYRKKLQDVYTDVEDVKiaisdrfkllqsQYTDeKYKEALEIIATKFGLTV 572
Cdd:COG5185   204 VNSIKESETGNLGSESTLLEKAKEIINIEEALKGFQDPESELEDLA------------QTSD-KLEKLVEQNTDLRLEKL 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  573 NEDLQLVGEPNVVKSAIEAARESTKEQLRDYVKTSDYKTDKDGIVERLDTAEAERTtlkgeikdkvtlneyrngLEEQKQ 652
Cdd:COG5185   271 GENAESSKRLNENANNLIKQFENTKEKIAEYTKSIDIKKATESLEEQLAAAEAEQE------------------LEESKR 332

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  653 YTDdqlsdlSNNPEIKASIEQANQEAQEALKSyidaqddLKEKESQAYADGKISEEEQRaIQDAQAKLEEAKQNAELKAR 732
Cdd:COG5185   333 ETE------TGIQNLTAEIEQGQESLTENLEA-------IKEEIENIVGEVELSKSSEE-LDSFKDTIESTKESLDEIPQ 398

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  733 NAEKKAnvytdnkvKESTDAQRKTLTRYGSQIIQNGKEIKLRTTK-EEFNATNRTLSNILNEIVQNVTDGTTIRYDDNGV 811
Cdd:COG5185   399 NQRGYA--------QEILATLEDTLKAADRQIEELQRQIEQATSSnEEVSKLLNELISELNKVMREADEESQSRLEEAYD 470

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 446504336  812 AQALNVGPRGIRLNADKIDINGN-REINLLIQNMRDKVDK 850
Cdd:COG5185   471 EINRSVRSKKEDLNEELTQIESRvSTLKATLEKLRAKLER 510
 
Name Accession Description Interval E-value
put_anti_recept TIGR01665
phage minor structural protein, N-terminal region; This model represents the conserved ...
 24-337 2.68e-82

phage minor structural protein, N-terminal region; This model represents the conserved N-terminal region, typically from about residue 25 to about residue 350, of a family of uncharacterized phage proteins 500 to 1700 residues in length. [Mobile and extrachromosomal element functions, Prophage functions]


Pssm-ID: 273743 [Multi-domain]  Cd Length: 317  Bit Score: 272.36  E-value: 2.68e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336    24 RAIHKRNVNDNSEMLELLISSE--RAEKFRKRHRVIIRDSN-KQWREFIINWVQDTmDGYTEIECIASYLADITTAKPYA 100
Cdd:TIGR01665    1 KDIKISEEKNNLDTLTFSLPFDdpLWEKIKEENYIKKHDDDlKNEQLFRINNVSED-ASDDSISVEAIHVAVDLLDHVII 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336   101 PGKFEKKTTSEALKDVLSDTgWEVSEQTEYDGLRTTSWTSYQTRYEVLKQLCTTYKMVLdFYIELSSNTVKGRYVVLKKK 180
Cdd:TIGR01665   80 PIKREKNTTSAALERLAKTT-WEVWKLGECSDIKTISITFYQTSRNALQAIAKLYKLSI-FYQWGGDNTITGKIVNLYKK 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336   181 NSLFKGKEIEYGKDLVGLTRKIDMSEIKTALIAVGPEN--DKGKRLELVVTDDEAQSQFnlPMRYIWGIYEPQSDDQNMN 258
Cdd:TIGR01665  158 IGSETGKEFEYGKNLVGLNRKEDTKNIVTRLIPFGKGEggEKGLTIESSNVGDEYIVDK--DRQYKPNVDTTWVDGRYTD 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336   259 ETRLSSLAKTELNKRK--SAVMSYEITSTDLEVTYP---HEIISIGDTVRVKHRDFNPPLYveAEVIAEEYNIISENSTY 333
Cdd:TIGR01665  236 ETTLRAYAKQKLMTLKkdMPKVSYEVTVADLENLSEyksLEPIGIGDTVRLKHTDFNIKVY--ARVIKVEYSPVTPKQNS 313


                   ....
gi 446504336   334 TFGQ 337
Cdd:TIGR01665  314 IEFG 317
PblB COG4926
Phage-related protein [Mobilome: prophages, transposons];
1-408 3.31e-27

Phage-related protein [Mobilome: prophages, transposons];


Pssm-ID: 443954 [Multi-domain]  Cd Length: 438  Bit Score: 116.30  E-value: 3.31e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336    1 MIHVLdFNDKIIDFLSTDDPSL---VRAIHKRNVNDNSEM-LELLISSERAEKFRKRHRVIIrDSNKQWREFIINWVQDT 76
Cdd:COG4926     1 MIPVL-YDKNETEFDTNGLGVLdnaYDAVVTEELNGEYTLeFEYPYDGEKAEHLENENIIKV-DTPRGNQLFRIYRVTKT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336   77 MDGYTEIEC--IASYLADITTAKPYapgkFEKKTTSEALKDVLSDT----GWEVSeqTEYDGLRTTSWtSYQTRYEVLK- 149
Cdd:COG4926    79 MDGTITVYAehIFYDLLDNFIEDTR----VTNVTAQTALNDILDGTqyphPFTGS--SDITTTRSAYV-VKKNALEALLg 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  150 ---QLCTTYKMVLDFYielssntvkGRYVVLKKKNSLFKGKEIEYGKDLVGLTRKIDMSEIKTALIAVGPENdkgkrlel 226
Cdd:COG4926   152 denSFASRWGGELRFD---------NYTVDLLKRRGRDRGVVIRYRKNLTGLERTVDTTEVVTRIYPYGKDG-------- 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  227 VVTDDEAQSQF--NLPMRYIWGI-YEPQSDDQNM-NETRLSSLAKTEL-NKRKSAVMSYEITSTDLEVT--YPH----EI 295
Cdd:COG4926   215 ITLPEYIDSPYieDYPYPKIKVIdYVSKFDDEDFtTPEQLREAAKEELkNGVDKPRVSYKVDFADLSQTeeYKHfkqlEA 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  296 ISIGDTVRVKHRDFNppLYVEAEVIAEEYNIIS-ENSTYTFGqpkefkesELREEFNKRLNLIhQKLNDNISNINTIVKD 374
Cdd:COG4926   295 VRLGDTVTVYDEKLG--IDLKARVVAYQYDVLApEYTEIELG--------SFVPSLTDSLTSI-DKLLDQVEESSKNINQ 363

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 446504336  375 IVDgeleYFERKIHKSD---TPPENpvNDTLWYDTSN 408
Cdd:COG4926   364 ASD----NATGLINSGNgklVPEYP--AEILIMDTEN 394
Prophage_tail pfam06605
Prophage endopeptidase tail; This family is of prophage tail proteins that are probably acting ...
 103-336 1.86e-16

Prophage endopeptidase tail; This family is of prophage tail proteins that are probably acting as endopeptidases.


Pssm-ID: 429028  Cd Length: 253  Bit Score: 80.44  E-value: 1.86e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336   103 KFEKKTTSEALKDVL----SDTGWEVSEQTEYDgLRTTSWTSYQTRYEVLKQLCTTYKMVLDFyielssntVKGRYVVLK 178
Cdd:pfam06605   14 KTGALSLEQALNFALdnntTGTTWEIGTVDSFP-SRTVENFGNNNALELLQQILEDFGGELRF--------DSNRHVDIY 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336   179 KKNSLFKGKEIEYGKDLVGLTRKIDMSEIKTALIAVGPENDKGKRLelvvtDDEAQSQFNLPMRYIWGIYEPQSDDQNMN 258
Cdd:pfam06605   85 KLVGKDTGATFRYGYNLKDIEIETDTTSLATRIYGYGKDDLTIETI-----NDGKEYLEDSPAVDKYGISRKADPITDDR 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336   259 ETRLSSL---AKTELNKRKSAVMSYEITSTDLEV-TYPHEIISIGDTVRVKHRDFNppLYVEAEVIAEEYNIIS-ENSTY 333
Cdd:pfam06605  160 FTDPDSLkeyAKEQLQEYSKPDVSLTVTAADLSKlTGEIEDFELGDYVRVIDEELG--LDVKVRIVGITRYPFEpWNTEL 237


                   ...
gi 446504336   334 TFG 336
Cdd:pfam06605  238 TLG 240
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 493-850 1.32e-07

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 56.12  E-value: 1.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  493 YNQIKNNLESMTPETATIGRLVDTKTLFLEYRKKLQDVYTDVEDVKiaisdrfkllqsQYTDeKYKEALEIIATKFGLTV 572
Cdd:COG5185   204 VNSIKESETGNLGSESTLLEKAKEIINIEEALKGFQDPESELEDLA------------QTSD-KLEKLVEQNTDLRLEKL 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  573 NEDLQLVGEPNVVKSAIEAARESTKEQLRDYVKTSDYKTDKDGIVERLDTAEAERTtlkgeikdkvtlneyrngLEEQKQ 652
Cdd:COG5185   271 GENAESSKRLNENANNLIKQFENTKEKIAEYTKSIDIKKATESLEEQLAAAEAEQE------------------LEESKR 332

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  653 YTDdqlsdlSNNPEIKASIEQANQEAQEALKSyidaqddLKEKESQAYADGKISEEEQRaIQDAQAKLEEAKQNAELKAR 732
Cdd:COG5185   333 ETE------TGIQNLTAEIEQGQESLTENLEA-------IKEEIENIVGEVELSKSSEE-LDSFKDTIESTKESLDEIPQ 398

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  733 NAEKKAnvytdnkvKESTDAQRKTLTRYGSQIIQNGKEIKLRTTK-EEFNATNRTLSNILNEIVQNVTDGTTIRYDDNGV 811
Cdd:COG5185   399 NQRGYA--------QEILATLEDTLKAADRQIEELQRQIEQATSSnEEVSKLLNELISELNKVMREADEESQSRLEEAYD 470

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 446504336  812 AQALNVGPRGIRLNADKIDINGN-REINLLIQNMRDKVDK 850
Cdd:COG5185   471 EINRSVRSKKEDLNEELTQIESRvSTLKATLEKLRAKLER 510
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
 536-739 1.97e-06

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 52.53  E-value: 1.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  536 DVKIAISDRFKLlqsqyTDEKYKEALEIIATKFGLTVNEDLQLVGEPNVVKSAIEAARESTKEQLRDYVKTSDYKTDKDG 615
Cdd:NF012221 1563 DKERAEADRQRL-----EQEKQQQLAAISGSQSQLESTDQNALETNGQAQRDAILEESRAVTKELTTLAQGLDALDSQAT 1637

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  616 IVERLDtaEAERTTLKGEIKDKV------TLNEYRNGLEEQKQYTDDQLSDLSNN-PEIKASIEQANQEAQEALKSYIDA 688
Cdd:NF012221 1638 YAGESG--DQWRNPFAGGLLDRVqeqlddAKKISGKQLADAKQRHVDNQQKVKDAvAKSEAGVAQGEQNQANAEQDIDDA 1715

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 446504336  689 QDDLKEKESQAYADGKiseEEQRAIQDAQAKLEEAKQNAELKARNAEKKAN 739
Cdd:NF012221 1716 KADAEKRKDDALAKQN---EAQQAESDANAAANDAQSRGEQDASAAENKAN 1763
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 618-755 3.89e-05

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 47.53  E-value: 3.89e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336   618 ERLDTAEAERTTLKGEIKDKVTLNEYRNGLEEQKQYTDDQLSDlsnnPEIKASIEQANQEAQEALKSYIDA---QDDLKE 694
Cdd:TIGR02794   58 QKKPAAKKEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAA----EKAAKQAEQAAKQAEEKQKQAEEAkakQAAEAK 133

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446504336   695 KESQAYADGKISEE-EQRAIQDAQAKleeAKQNAELKARNAEKKAnvytDNKVKESTDAQRK 755
Cdd:TIGR02794  134 AKAEAEAERKAKEEaAKQAEEEAKAK---AAAEAKKKAEEAKKKA----EAEAKAKAEAEAK 188
PTZ00121 PTZ00121
MAEBL; Provisional
 573-755 5.76e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.83  E-value: 5.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  573 NEDLQLVGEPNVVKSAIEAARESTKEQLR-DYVKTSDYKTDKDGIVERLDTAEAERTTLKGEIKDKVtlNEYRNGLEEQK 651
Cdd:PTZ00121 1251 NEEIRKFEEARMAHFARRQAAIKAEEARKaDELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKA--DEAKKKAEEAK 1328

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  652 QYTDdqlsdlsnnpEIKASIEQANQEAQEALKSYIDAQDDLKEKESQAYADGKISEEEQRAIQDAQAKLEEAKQNAELKA 731
Cdd:PTZ00121 1329 KKAD----------AAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKK 1398

                         170       180
                  ....*....|....*....|....
gi 446504336  732 RNAEKKANVytdNKVKESTDAQRK 755
Cdd:PTZ00121 1399 KAEEDKKKA---DELKKAAAAKKK 1419
 
Name Accession Description Interval E-value
put_anti_recept TIGR01665
phage minor structural protein, N-terminal region; This model represents the conserved ...
 24-337 2.68e-82

phage minor structural protein, N-terminal region; This model represents the conserved N-terminal region, typically from about residue 25 to about residue 350, of a family of uncharacterized phage proteins 500 to 1700 residues in length. [Mobile and extrachromosomal element functions, Prophage functions]


Pssm-ID: 273743 [Multi-domain]  Cd Length: 317  Bit Score: 272.36  E-value: 2.68e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336    24 RAIHKRNVNDNSEMLELLISSE--RAEKFRKRHRVIIRDSN-KQWREFIINWVQDTmDGYTEIECIASYLADITTAKPYA 100
Cdd:TIGR01665    1 KDIKISEEKNNLDTLTFSLPFDdpLWEKIKEENYIKKHDDDlKNEQLFRINNVSED-ASDDSISVEAIHVAVDLLDHVII 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336   101 PGKFEKKTTSEALKDVLSDTgWEVSEQTEYDGLRTTSWTSYQTRYEVLKQLCTTYKMVLdFYIELSSNTVKGRYVVLKKK 180
Cdd:TIGR01665   80 PIKREKNTTSAALERLAKTT-WEVWKLGECSDIKTISITFYQTSRNALQAIAKLYKLSI-FYQWGGDNTITGKIVNLYKK 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336   181 NSLFKGKEIEYGKDLVGLTRKIDMSEIKTALIAVGPEN--DKGKRLELVVTDDEAQSQFnlPMRYIWGIYEPQSDDQNMN 258
Cdd:TIGR01665  158 IGSETGKEFEYGKNLVGLNRKEDTKNIVTRLIPFGKGEggEKGLTIESSNVGDEYIVDK--DRQYKPNVDTTWVDGRYTD 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336   259 ETRLSSLAKTELNKRK--SAVMSYEITSTDLEVTYP---HEIISIGDTVRVKHRDFNPPLYveAEVIAEEYNIISENSTY 333
Cdd:TIGR01665  236 ETTLRAYAKQKLMTLKkdMPKVSYEVTVADLENLSEyksLEPIGIGDTVRLKHTDFNIKVY--ARVIKVEYSPVTPKQNS 313


                   ....
gi 446504336   334 TFGQ 337
Cdd:TIGR01665  314 IEFG 317
PblB COG4926
Phage-related protein [Mobilome: prophages, transposons];
1-408 3.31e-27

Phage-related protein [Mobilome: prophages, transposons];


Pssm-ID: 443954 [Multi-domain]  Cd Length: 438  Bit Score: 116.30  E-value: 3.31e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336    1 MIHVLdFNDKIIDFLSTDDPSL---VRAIHKRNVNDNSEM-LELLISSERAEKFRKRHRVIIrDSNKQWREFIINWVQDT 76
Cdd:COG4926     1 MIPVL-YDKNETEFDTNGLGVLdnaYDAVVTEELNGEYTLeFEYPYDGEKAEHLENENIIKV-DTPRGNQLFRIYRVTKT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336   77 MDGYTEIEC--IASYLADITTAKPYapgkFEKKTTSEALKDVLSDT----GWEVSeqTEYDGLRTTSWtSYQTRYEVLK- 149
Cdd:COG4926    79 MDGTITVYAehIFYDLLDNFIEDTR----VTNVTAQTALNDILDGTqyphPFTGS--SDITTTRSAYV-VKKNALEALLg 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  150 ---QLCTTYKMVLDFYielssntvkGRYVVLKKKNSLFKGKEIEYGKDLVGLTRKIDMSEIKTALIAVGPENdkgkrlel 226
Cdd:COG4926   152 denSFASRWGGELRFD---------NYTVDLLKRRGRDRGVVIRYRKNLTGLERTVDTTEVVTRIYPYGKDG-------- 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  227 VVTDDEAQSQF--NLPMRYIWGI-YEPQSDDQNM-NETRLSSLAKTEL-NKRKSAVMSYEITSTDLEVT--YPH----EI 295
Cdd:COG4926   215 ITLPEYIDSPYieDYPYPKIKVIdYVSKFDDEDFtTPEQLREAAKEELkNGVDKPRVSYKVDFADLSQTeeYKHfkqlEA 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  296 ISIGDTVRVKHRDFNppLYVEAEVIAEEYNIIS-ENSTYTFGqpkefkesELREEFNKRLNLIhQKLNDNISNINTIVKD 374
Cdd:COG4926   295 VRLGDTVTVYDEKLG--IDLKARVVAYQYDVLApEYTEIELG--------SFVPSLTDSLTSI-DKLLDQVEESSKNINQ 363

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 446504336  375 IVDgeleYFERKIHKSD---TPPENpvNDTLWYDTSN 408
Cdd:COG4926   364 ASD----NATGLINSGNgklVPEYP--AEILIMDTEN 394
Prophage_tail pfam06605
Prophage endopeptidase tail; This family is of prophage tail proteins that are probably acting ...
 103-336 1.86e-16

Prophage endopeptidase tail; This family is of prophage tail proteins that are probably acting as endopeptidases.


Pssm-ID: 429028  Cd Length: 253  Bit Score: 80.44  E-value: 1.86e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336   103 KFEKKTTSEALKDVL----SDTGWEVSEQTEYDgLRTTSWTSYQTRYEVLKQLCTTYKMVLDFyielssntVKGRYVVLK 178
Cdd:pfam06605   14 KTGALSLEQALNFALdnntTGTTWEIGTVDSFP-SRTVENFGNNNALELLQQILEDFGGELRF--------DSNRHVDIY 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336   179 KKNSLFKGKEIEYGKDLVGLTRKIDMSEIKTALIAVGPENDKGKRLelvvtDDEAQSQFNLPMRYIWGIYEPQSDDQNMN 258
Cdd:pfam06605   85 KLVGKDTGATFRYGYNLKDIEIETDTTSLATRIYGYGKDDLTIETI-----NDGKEYLEDSPAVDKYGISRKADPITDDR 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336   259 ETRLSSL---AKTELNKRKSAVMSYEITSTDLEV-TYPHEIISIGDTVRVKHRDFNppLYVEAEVIAEEYNIIS-ENSTY 333
Cdd:pfam06605  160 FTDPDSLkeyAKEQLQEYSKPDVSLTVTAADLSKlTGEIEDFELGDYVRVIDEELG--LDVKVRIVGITRYPFEpWNTEL 237


                   ...
gi 446504336   334 TFG 336
Cdd:pfam06605  238 TLG 240
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 493-850 1.32e-07

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 56.12  E-value: 1.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  493 YNQIKNNLESMTPETATIGRLVDTKTLFLEYRKKLQDVYTDVEDVKiaisdrfkllqsQYTDeKYKEALEIIATKFGLTV 572
Cdd:COG5185   204 VNSIKESETGNLGSESTLLEKAKEIINIEEALKGFQDPESELEDLA------------QTSD-KLEKLVEQNTDLRLEKL 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  573 NEDLQLVGEPNVVKSAIEAARESTKEQLRDYVKTSDYKTDKDGIVERLDTAEAERTtlkgeikdkvtlneyrngLEEQKQ 652
Cdd:COG5185   271 GENAESSKRLNENANNLIKQFENTKEKIAEYTKSIDIKKATESLEEQLAAAEAEQE------------------LEESKR 332

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  653 YTDdqlsdlSNNPEIKASIEQANQEAQEALKSyidaqddLKEKESQAYADGKISEEEQRaIQDAQAKLEEAKQNAELKAR 732
Cdd:COG5185   333 ETE------TGIQNLTAEIEQGQESLTENLEA-------IKEEIENIVGEVELSKSSEE-LDSFKDTIESTKESLDEIPQ 398

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  733 NAEKKAnvytdnkvKESTDAQRKTLTRYGSQIIQNGKEIKLRTTK-EEFNATNRTLSNILNEIVQNVTDGTTIRYDDNGV 811
Cdd:COG5185   399 NQRGYA--------QEILATLEDTLKAADRQIEELQRQIEQATSSnEEVSKLLNELISELNKVMREADEESQSRLEEAYD 470

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 446504336  812 AQALNVGPRGIRLNADKIDINGN-REINLLIQNMRDKVDK 850
Cdd:COG5185   471 EINRSVRSKKEDLNEELTQIESRvSTLKATLEKLRAKLER 510
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
 536-739 1.97e-06

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 52.53  E-value: 1.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  536 DVKIAISDRFKLlqsqyTDEKYKEALEIIATKFGLTVNEDLQLVGEPNVVKSAIEAARESTKEQLRDYVKTSDYKTDKDG 615
Cdd:NF012221 1563 DKERAEADRQRL-----EQEKQQQLAAISGSQSQLESTDQNALETNGQAQRDAILEESRAVTKELTTLAQGLDALDSQAT 1637

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  616 IVERLDtaEAERTTLKGEIKDKV------TLNEYRNGLEEQKQYTDDQLSDLSNN-PEIKASIEQANQEAQEALKSYIDA 688
Cdd:NF012221 1638 YAGESG--DQWRNPFAGGLLDRVqeqlddAKKISGKQLADAKQRHVDNQQKVKDAvAKSEAGVAQGEQNQANAEQDIDDA 1715

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 446504336  689 QDDLKEKESQAYADGKiseEEQRAIQDAQAKLEEAKQNAELKARNAEKKAN 739
Cdd:NF012221 1716 KADAEKRKDDALAKQN---EAQQAESDANAAANDAQSRGEQDASAAENKAN 1763
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 618-755 3.89e-05

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 47.53  E-value: 3.89e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336   618 ERLDTAEAERTTLKGEIKDKVTLNEYRNGLEEQKQYTDDQLSDlsnnPEIKASIEQANQEAQEALKSYIDA---QDDLKE 694
Cdd:TIGR02794   58 QKKPAAKKEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAA----EKAAKQAEQAAKQAEEKQKQAEEAkakQAAEAK 133

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446504336   695 KESQAYADGKISEE-EQRAIQDAQAKleeAKQNAELKARNAEKKAnvytDNKVKESTDAQRK 755
Cdd:TIGR02794  134 AKAEAEAERKAKEEaAKQAEEEAKAK---AAAEAKKKAEEAKKKA----EAEAKAKAEAEAK 188
PTZ00121 PTZ00121
MAEBL; Provisional
 573-755 5.76e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.83  E-value: 5.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  573 NEDLQLVGEPNVVKSAIEAARESTKEQLR-DYVKTSDYKTDKDGIVERLDTAEAERTTLKGEIKDKVtlNEYRNGLEEQK 651
Cdd:PTZ00121 1251 NEEIRKFEEARMAHFARRQAAIKAEEARKaDELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKA--DEAKKKAEEAK 1328

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  652 QYTDdqlsdlsnnpEIKASIEQANQEAQEALKSYIDAQDDLKEKESQAYADGKISEEEQRAIQDAQAKLEEAKQNAELKA 731
Cdd:PTZ00121 1329 KKAD----------AAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKK 1398

                         170       180
                  ....*....|....*....|....
gi 446504336  732 RNAEKKANVytdNKVKESTDAQRK 755
Cdd:PTZ00121 1399 KAEEDKKKA---DELKKAAAAKKK 1419
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 671-755 1.84e-04

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 45.57  E-value: 1.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  671 IEQANQEAQEALKSYIDAQDDLKEKESQAyadgkiseEEQRAIQDAQAKL---EEAKQNAELKAR-NAEKKANVYTDNKV 746
Cdd:PRK09510  106 LEKERLAAQEQKKQAEEAAKQAALKQKQA--------EEAAAKAAAAAKAkaeAEAKRAAAAAKKaAAEAKKKAEAEAAK 177


                  ....*....
gi 446504336  747 KESTDAQRK 755
Cdd:PRK09510  178 KAAAEAKKK 186
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 534-764 2.33e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.82  E-value: 2.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336   534 VEDVKIAISDRFKLLQSQY-TDEKYKE-ALEIIATKFGLTVNEDLQLVGEpnvvksaIEAARESTKEQLRDYVKTSDYKT 611
Cdd:TIGR02168  191 LEDILNELERQLKSLERQAeKAERYKElKAELRELELALLVLRLEELREE-------LEELQEELKEAEEELEELTAELQ 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336   612 DKDGIVERLDTAEAERTTLKGEIKDKV-TLNEYRNGLEEQKQYTDDQLSDLSNNpeikasIEQANQEAQEALKSYIDAQD 690
Cdd:TIGR02168  264 ELEEKLEELRLEVSELEEEIEELQKELyALANEISRLEQQKQILRERLANLERQ------LEELEAQLEELESKLDELAE 337

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446504336   691 DLKEKESQAYADGKISEEEQRAIQDAQAKLEEAKQNAELKARNAEKKANVYtdNKVKESTDAQRKTLTRYGSQI 764
Cdd:TIGR02168  338 ELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKV--AQLELQIASLNNEIERLEARL 409
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
522-732 2.76e-04

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 45.42  E-value: 2.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  522 EYRKKLQDVYTDVEDVKIAISDRFKLLQSQYTDekyKEALEIIATKFGL-----TVNEDLQlvgEPNVVKSAIEAAREST 596
Cdd:PRK02224  166 EYRERASDARLGVERVLSDQRGSLDQLKAQIEE---KEEKDLHERLNGLeselaELDEEIE---RYEEQREQARETRDEA 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  597 KEQLRDYVKT----SDYKTDKDGIVERLDTAEAERTTLKGEIKDK----VTLNEYRNGLEEQKQYTD-------DQLSDL 661
Cdd:PRK02224  240 DEVLEEHEERreelETLEAEIEDLRETIAETEREREELAEEVRDLrerlEELEEERDDLLAEAGLDDadaeaveARREEL 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  662 SN-NPEIKASIEQANQEAQEALK---SYIDAQDDL----KEKESQAYADGKISEEEQRAIQDAQAKLEE-AKQNAELKAR 732
Cdd:PRK02224  320 EDrDEELRDRLEECRVAAQAHNEeaeSLREDADDLeeraEELREEAAELESELEEAREAVEDRREEIEElEEEIEELRER 399
PRK01156 PRK01156
chromosome segregation protein; Provisional
 466-720 5.60e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 44.51  E-value: 5.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  466 ELLNSEYLVDN-DLKADLQASLDAVIDVYNQIKNNLESMTPETATIGRLVD----TKTLFLEYRKKLQDVYTDVEDVKIA 540
Cdd:PRK01156  157 EILEINSLERNyDKLKDVIDMLRAEISNIDYLEEKLKSSNLELENIKKQIAddekSHSITLKEIERLSIEYNNAMDDYNN 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  541 ISDRFKLLQSQY-TDEKYKEALEIIATKFGLTVNEDLQLVGEPNVVKSAIEAARESTKEQLRDYVKTSDYKTDKDGIVER 619
Cdd:PRK01156  237 LKSALNELSSLEdMKNRYESEIKTAESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQILSN 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  620 LDtaeAERTTLKGEIKDKVTLNEYRNGLEEQKQYTDD---QLSDL----SNNPEIKASIEQANQEAQEALKSYIDAQDDL 692
Cdd:PRK01156  317 ID---AEINKYHAIIKKLSVLQKDYNDYIKKKSRYDDlnnQILELegyeMDYNSYLKSIESLKKKIEEYSKNIERMSAFI 393

                         250       260       270
                  ....*....|....*....|....*....|..
gi 446504336  693 KEKESQAYADG----KISEEEQRAIQDAQAKL 720
Cdd:PRK01156  394 SEILKIQEIDPdaikKELNEINVKLQDISSKV 425
PTZ00121 PTZ00121
MAEBL; Provisional
 586-772 8.26e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.98  E-value: 8.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  586 KSAIEAARESTKEQLRDYVKTSDYKTDKDGIVERLDTA-EAERTTLKGEiKDKVTLNEYRNGLEEQKQYTD--------D 656
Cdd:PTZ00121 1353 EAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKkKADEAKKKAE-EDKKKADELKKAAAAKKKADEakkkaeekK 1431

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  657 QLSDLSNNPEIKASIEQANQEAQEALKsyidAQDDLKEKESQAYAD-GKISEEEQRAIQDAQAKLEEAKQNAE--LKARN 733
Cdd:PTZ00121 1432 KADEAKKKAEEAKKADEAKKKAEEAKK----AEEAKKKAEEAKKADeAKKKAEEAKKADEAKKKAEEAKKKADeaKKAAE 1507

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 446504336  734 AEKKANVYTDNKVKESTDAQRKTLTRYGSQIIQNGKEIK 772
Cdd:PTZ00121 1508 AKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKK 1546
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 587-757 1.92e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.12  E-value: 1.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  587 SAIEAARESTKEQLRD-YVKTSDYKTDKDGIVERLDTAEAERTTLKGEIKD-KVTLNEYRNGLEEQ--KQYTDDQLSDL- 661
Cdd:COG3883    26 SELQAELEAAQAELDAlQAELEELNEEYNELQAELEALQAEIDKLQAEIAEaEAEIEERREELGERarALYRSGGSVSYl 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  662 -----SNNPE--IK--ASIEQANQEAQEALKSYIDAQDDLKEKESQAyadgkisEEEQRAIQDAQAKLEEAKqnAELKAR 732
Cdd:COG3883   106 dvllgSESFSdfLDrlSALSKIADADADLLEELKADKAELEAKKAEL-------EAKLAELEALKAELEAAK--AELEAQ 176

                         170       180
                  ....*....|....*....|....*
gi 446504336  733 NAEKKANVYTDNKVKESTDAQRKTL 757
Cdd:COG3883   177 QAEQEALLAQLSAEEAAAEAQLAEL 201
TolA COG3064
Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
618-931 2.17e-03

Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442298 [Multi-domain]  Cd Length: 485  Bit Score: 42.33  E-value: 2.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  618 ERLDTAEAERTTLKgEIKDKVtlneyRNGLEEQKQYTDDQLSDLSNN-PEIKASIEQANQEAQ-EALKSYIDAQDDLKEK 695
Cdd:COG3064    16 ERLEQAEAEKRAAA-EAEQKA-----KEEAEEERLAELEAKRQAEEEaREAKAEAEQRAAELAaEAAKKLAEAEKAAAEA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  696 ESQAyadgkiSEEEQRAIQDAQAKLEEAKQNAELKA-------RNAEKKANVYTDNKVKESTDAQRKTLTRYGSQIIQNG 768
Cdd:COG3064    90 EKKA------AAEKAKAAKEAEAAAAAEKAAAAAEKekaeeakRKAEEEAKRKAEEERKAAEAEAAAKAEAEAARAAAAA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  769 KEIKLRTTKEEFNATNRTLSNILNEIVQNVTDGTTIRYDDNGVAQALNVGPRGIRLNADKIDINGNREINLLIQNMRDKV 848
Cdd:COG3064   164 AAAAAAAAARAAAGAAAALVAAAAAAVEAADTAAAAAAALAAAAAAAAADAALLALAVAARAAAASREAALAAVEATEEA 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  849 DKTDIVNSLNLSREGLDINVNRIGIKGGDNNRYVQIQNDSIELGGIVQRTWRGKRSTDDIFTRLKDGHLRFRNNTAGGSL 928
Cdd:COG3064   244 ALGGAEEAADLAAVGVLGAALAAAAAGAAALSSGLVVVAAALAGLAAAAAGLVLDDSAALAAELLGAVAAEEAVLAAAAA 323


                  ...
gi 446504336  929 YMS 931
Cdd:COG3064   324 AGA 326
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 610-779 3.13e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.85  E-value: 3.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  610 KTDKDGIVERLDTAEAERTTLKGEIKDK-VTLNEYRNGLEEQKQYTDDQLSDLSNNPEIKASIEQANQEAQEALKSYIDA 688
Cdd:COG1196   252 EAELEELEAELAELEAELEELRLELEELeLELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEE 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  689 QDDLKEKESQAYADGKISEEEQRAIQDAQAKLEEAKQNAELKARNAEKKANVYTDNKVKESTDAQRKTLTRYGSQIIQNG 768
Cdd:COG1196   332 LEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEA 411

                         170
                  ....*....|.
gi 446504336  769 KEIKLRTTKEE 779
Cdd:COG1196   412 LLERLERLEEE 422
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 522-739 3.43e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 41.35  E-value: 3.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  522 EYRKKLQDVYTDVEDVKIAISDrfklLQSQY--TDEKYKEALEIIATKfgltvNEDL-QLVGEPNVVKSAIEAARESTKE 598
Cdd:COG3883    20 AKQKELSELQAELEAAQAELDA----LQAELeeLNEEYNELQAELEAL-----QAEIdKLQAEIAEAEAEIEERREELGE 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  599 QLRDYvktsdYKTDKD-GIVERLDTAE-----AERTTLKGEI--KDKVTLNEY---RNGLEEQKQYTDDQLSDLSNNpei 667
Cdd:COG3883    91 RARAL-----YRSGGSvSYLDVLLGSEsfsdfLDRLSALSKIadADADLLEELkadKAELEAKKAELEAKLAELEAL--- 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446504336  668 KASIEQANQEAQEALKSYIDAQDDLKEKESQAYADGKISEEEQRAIQDAQAKLEEAKQNAELKARNAEKKAN 739
Cdd:COG3883   163 KAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAA 234
PRK13676 PRK13676
YlbF/YmcA family competence regulator;
660-741 3.79e-03

YlbF/YmcA family competence regulator;


Pssm-ID: 237467 [Multi-domain]  Cd Length: 114  Bit Score: 38.38  E-value: 3.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  660 DLSNNPEIKASIE-----QANQEAQEALKSYIDAQDDLKEKESQAyadGKISEEEQRAIQDAQAKLEeakQNAELKA-RN 733
Cdd:PRK13676   15 ALRELPEYKALKEakeavKADEEAKKLFDEFRALQLEIQQKQMTG---QEITEEEQQKAQELGQKIQ---QNELLSKlME 88


                  ....*...
gi 446504336  734 AEKKANVY 741
Cdd:PRK13676   89 AEQRLSVY 96
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
618-796 3.80e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.82  E-value: 3.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  618 ERLDTAEAERTTLKGEIKdkvTLNEYRNGLEEQKQYTDDQLsDLsnnpeikASIEQANQEAQEALKSYIDAQDDLKEKES 697
Cdd:COG4913   624 EELAEAEERLEALEAELD---ALQERREALQRLAEYSWDEI-DV-------ASAEREIAELEAELERLDASSDDLAALEE 692

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  698 Q---AYADGKISEEEQRAIQDAQAKLEEAKQNAELKARNAEKKANVYTDNKVKEST---DAQRKTLTRYGS-QIIQNGKE 770
Cdd:COG4913   693 QleeLEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRallEERFAAALGDAVeRELRENLE 772

                         170       180
                  ....*....|....*....|....*.
gi 446504336  771 IKLRTTKEEFNATNRTLSNILNEIVQ 796
Cdd:COG4913   773 ERIDALRARLNRAEEELERAMRAFNR 798
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 522-788 3.96e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 41.57  E-value: 3.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336   522 EYRKKLQDVYTDVEDVKIAISDRFKLLQSQYTDEKYKEALEIiatkfGLTVNEDLQLVGEPNVVKSAIEAARESTKEQLR 601
Cdd:TIGR00606  748 ELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLT-----DVTIMERFQMELKDVERKIAQQAAKLQGSDLDR 822

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336   602 DYVKTSDYKTDKDgivERLDTAEAERTTLKGEIKD--------KVTLNE---YRNGLEE---QKQYTDDQLSDLSNnpEI 667
Cdd:TIGR00606  823 TVQQVNQEKQEKQ---HELDTVVSKIELNRKLIQDqqeqiqhlKSKTNElksEKLQIGTnlqRRQQFEEQLVELST--EV 897

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336   668 KASIEQANQEAQEALKSYIDAQDDLKEKESQAyadgkiseeeqraiqdaqAKLEEAKQNAELKARNAEKKanvyTDNKVk 747
Cdd:TIGR00606  898 QSLIREIKDAKEQDSPLETFLEKDQQEKEELI------------------SSKETSNKKAQDKVNDIKEK----VKNIH- 954

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 446504336   748 estdAQRKTLTRYgsqiIQNGKEIKLRTTKEEFNATNRTLS 788
Cdd:TIGR00606  955 ----GYMKDIENK----IQDGKDDYLKQKETELNTVNAQLE 987
PTZ00121 PTZ00121
MAEBL; Provisional
 589-756 4.17e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 4.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  589 IEAARESTKEQLRDYVKTSD---------YKTDKDGIVERLDTAEAERTTLKGEIKDKVTLNEYRNGlEEQKQYTDDQLS 659
Cdd:PTZ00121 1214 AEEARKAEDAKKAEAVKKAEeakkdaeeaKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKA-DELKKAEEKKKA 1292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  660 DLSNNPEIKASIEQANQEAQEALKSyidaqDDLKEKesqayadgkiSEEEQRAIQDAQAKLEEAKQNAELKARNAEKKAN 739
Cdd:PTZ00121 1293 DEAKKAEEKKKADEAKKKAEEAKKA-----DEAKKK----------AEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAAD 1357

                         170
                  ....*....|....*..
gi 446504336  740 VYTDNKVKESTDAQRKT 756
Cdd:PTZ00121 1358 EAEAAEEKAEAAEKKKE 1374
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
588-738 5.29e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.91  E-value: 5.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  588 AIEAARESTKEQLRDYvktSDYKTDKDGIVERLDTAEAERTTLKGEIKDKVTLNEYRNGLEEQKQyTDDQLSDLsnnPEI 667
Cdd:COG4717    75 ELEEELKEAEEKEEEY---AELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEA-LEAELAEL---PER 147

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446504336  668 KASIEQANQEAQEALKSYIDAQDDLKEKESQAYADGK-ISEEEQRAIQDAQAKLEEAKQNAElKARNAEKKA 738
Cdd:COG4717   148 LEELEERLEELRELEEELEELEAELAELQEELEELLEqLSLATEEELQDLAEELEELQQRLA-ELEEELEEA 218
TolA COG3064
Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
591-918 5.30e-03

Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442298 [Multi-domain]  Cd Length: 485  Bit Score: 40.79  E-value: 5.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  591 AARESTKEQLRDYVKTSDYKTDKDGIVERLDTAEAERT--TLKGEIKDKVTLNEyrngLEEQKQYTDDQLSDLSNNPEIK 668
Cdd:COG3064    19 EQAEAEKRAAAEAEQKAKEEAEEERLAELEAKRQAEEEarEAKAEAEQRAAELA----AEAAKKLAEAEKAAAEAEKKAA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  669 ASIEQANQEAQEALKsyidaqddlKEKESQAYADGKISEEEQRAIQDAQAKLEEAKQNAELKARNAEKKANVYTDNKVKE 748
Cdd:COG3064    95 AEKAKAAKEAEAAAA---------AEKAAAAAEKEKAEEAKRKAEEEAKRKAEEERKAAEAEAAAKAEAEAARAAAAAAA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  749 STDAQRKTLTRYGSQIIQNGKEIKLRTTKEEFNATNRTLSNILNEIVQNVTDGTTIRYDDNGVAQALNVGPRGIRLNADK 828
Cdd:COG3064   166 AAAAAAARAAAGAAAALVAAAAAAVEAADTAAAAAAALAAAAAAAAADAALLALAVAARAAAASREAALAAVEATEEAAL 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  829 IDINGNREINLLIQNMRDKVDKTDIVNSLNLSREGLDINVNRIGIKGGDNNRYVQIQNDSIELGGIVQRTWRGKRSTDDI 908
Cdd:COG3064   246 GGAEEAADLAAVGVLGAALAAAAAGAAALSSGLVVVAAALAGLAAAAAGLVLDDSAALAAELLGAVAAEEAVLAAAAAAG 325

                         330
                  ....*....|
gi 446504336  909 FTRLKDGHLR 918
Cdd:COG3064   326 ALVVRGGGAA 335
PTZ00121 PTZ00121
MAEBL; Provisional
 586-753 5.59e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 5.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  586 KSAIEAARESTKEQLRDYVKTSDYKTDKDgiverldtaEAERTTLKGEIKDKVTLNEYRNGLEEQKQYTDDQLSDlsnnp 665
Cdd:PTZ00121 1329 KKADAAKKKAEEAKKAAEAAKAEAEAAAD---------EAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKAD----- 1394

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  666 EIKASIEQANQEAQEALKsyidaqddlKEKESQAYADGKISEEEQRAIQDAQAKLEEAKQNAELKARNAEKKANVYTDNK 745
Cdd:PTZ00121 1395 EAKKKAEEDKKKADELKK---------AAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKK 1465


                  ....*...
gi 446504336  746 VKESTDAQ 753
Cdd:PTZ00121 1466 AEEAKKAD 1473
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
617-916 6.52e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 40.27  E-value: 6.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  617 VERLDTAEAERTTLKGEIKDKVT--------LNEYRNGLEEQKQYTDDQLSDLSNNPE----IKASIEQANQEA---QEA 681
Cdd:COG4372    37 LFELDKLQEELEQLREELEQAREeleqleeeLEQARSELEQLEEELEELNEQLQAAQAelaqAQEELESLQEEAeelQEE 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  682 LKSYIDAQDDLKEKESQAYADGKISEEEQRAIQDAQAKLEEAKQNAELKARNAEKKANVYTDNKVKESTDAQRKTLTRYG 761
Cdd:COG4372   117 LEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEANRNA 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446504336  762 SQIIQNGKEIKLRTTKEEFNA---TNRTLSNILNEIVQNVTDGTTIRYDDNGVAQALNVGPRGIRLNADKIDINGNREIN 838
Cdd:COG4372   197 EKEEELAEAEKLIESLPRELAeelLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEE 276

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446504336  839 LLIQNMRDKVDKTDIVNSLNLSREGLDINVNRIGIKGGDNNRYVQIQNDSIELGGIVQRTWRGKRSTDDIFTRLKDGH 916
Cdd:COG4372   277 ELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLLLVGLLDND 354
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH