|
Name |
Accession |
Description |
Interval |
E-value |
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
1-457 |
0e+00 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 812.63 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 1 MIGSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQRQGLMIEQHVEAELANDPPNDLMWWRRLFRAIDKWAP 80
Cdd:PRK09470 5 MINSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQRQGLMIEQHIEAELANDPPNDLMWWRRLFRAIDKWAP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 81 PGQRLLLVTTEGRVIGAERSEMQIIRNFIGQADNADHPQKKKYGRVELVGPFSVRDGEDNYQLYLIRPASSSQSDFINLL 160
Cdd:PRK09470 85 PGQRLLLVTSEGRIIGAERSEMQAVRNFIGQSDNADHPQKKKYGRVEIVGPFSVRDGEDNYQLYLIRPANSPQSDFINLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 161 FDRPLLLLIVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALGRMMTSQQ 240
Cdd:PRK09470 165 FDRPLLLLLVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELETGPQEFRQAGASFNQMVTALERMMTSQQ 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 241 RLLSDISHELRTPLTRLQLGTALLRRRSGESKELERIETEAQRLDSMINDLLVMSRNQQKNALVSETIKANQLWSEVLDN 320
Cdd:PRK09470 245 RLLSDISHELRTPLTRLQLATALLRRRQGESKELERIETEAQRLDSMINDLLVLSRNQQKNHLERETFKANSLWSEVLED 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 321 AAFEAEQMGKSLTVNFPPGPWPLYGNPNALESALENIVRNALRYSHTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIF 400
Cdd:PRK09470 325 AKFEAEQMGKSLTVSAPPGPWPINGNPNALASALENIVRNALRYSHTKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIF 404
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 446502575 401 RPFYRTDEARDRESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPLYKRS 457
Cdd:PRK09470 405 RPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLPLYKRS 461
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
138-455 |
6.05e-69 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 224.43 E-value: 6.05e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 138 EDNYQLYLIRPASSSQSDFINLLFDRPLLLLIVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELEAGPQE 217
Cdd:COG5002 64 LLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLL 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 218 FLAAGASFNQMVTALGRMMTSQQRLLSDISHELRTPLTRLQLGTALLRRRSGESKE-----LERIETEAQRLDSMINDLL 292
Cdd:COG5002 144 GLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEerreyLEIILEEAERLSRLVNDLL 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 293 VMSR-NQQKNALVSETIKANQLWSEVLDNAAFEAEQMGKSLTVNFPPGPWPLYGNPNALESALENIVRNALRYSH--TKI 369
Cdd:COG5002 224 DLSRlESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPegGTI 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 370 EVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVI 449
Cdd:COG5002 304 TVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTI 383
|
....*.
gi 446502575 450 WLPLYK 455
Cdd:COG5002 384 TLPLAR 389
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
196-453 |
2.08e-63 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 208.22 E-value: 2.08e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 196 AADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALGRMMTSQQRLLSDISHELRTPLTRLQLGTALLRRRSGE--SKE 273
Cdd:COG0642 67 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEeqREY 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 274 LERIETEAQRLDSMINDLLVMSR-NQQKNALVSETIKANQLWSEVLDNAAFEAEQMGKSLTVNFPPGPWPLYGNPNALES 352
Cdd:COG0642 147 LETILRSADRLLRLINDLLDLSRlEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQ 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 353 ALENIVRNALRYSH--TKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEArdRESGGTGLGLAIVETAIQQ 430
Cdd:COG0642 227 VLLNLLSNAIKYTPegGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPS--RRGGGTGLGLAIVKRIVEL 304
|
250 260
....*....|....*....|...
gi 446502575 431 HRGWVKAEDSPLGGLRLVIWLPL 453
Cdd:COG0642 305 HGGTIEVESEPGKGTTFTVTLPL 327
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
226-453 |
3.77e-61 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 198.98 E-value: 3.77e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 226 NQMVTALGRMMTSQQRLLSDISHELRTPLTRLQLGTALLRRRSGESKE-----LERIETEAQRLDSMINDLLVMSRNQ-Q 299
Cdd:COG2205 3 EEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEerrelLEIIRESAERLLRLIEDLLDLSRLEsG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 300 KNALVSETIKANQLWSEVLDNAAFEAEQMGKSLTVNFPPGPWPLYGNPNALESALENIVRNALRYS--HTKIEVGFAVDK 377
Cdd:COG2205 83 KLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSppGGTITISARREG 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446502575 378 DGITITVDDDGPGVSPEDREQIFRPFYRTDeaRDRESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPL 453
Cdd:COG2205 163 DGVRISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-453 |
2.30e-60 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 192.16 E-value: 2.30e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 350 LESALENIVRNALRYSHTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVETAIQ 429
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIE 80
|
90 100
....*....|....*....|....
gi 446502575 430 QHRGWVKAEDSPLGGLRLVIWLPL 453
Cdd:cd16949 81 QHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
188-454 |
2.05e-53 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 184.81 E-value: 2.05e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 188 KPARKLKNAADEVAQGNLRQHPELEAGpQEFLAAGASFNQMVTALGRMMTSQQRLLSDISHELRTPLTRLQLGTALLRRR 267
Cdd:PRK10604 162 QDMLKLEAAAQRLGDGHLAERIHFDEG-SSLERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSDNL 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 268 S-GESKELERietEAQRLDSMINDLLVMSR-NQQKNALVSETIKANQLWSEVLDNaaFEAEQMGKSLTVNFPPGPWPLYG 345
Cdd:PRK10604 241 SaAESQALNR---DIGQLEALIEELLTYARlDRPQNELHLSEPDLPAWLSTHLAD--IQAVTPEKTVRLDTPHQGDYGAL 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 346 NPNALESALENIVRNALRYSHTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVE 425
Cdd:PRK10604 316 DMRLMERVLDNLLNNALRYAHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVH 395
|
250 260
....*....|....*....|....*....
gi 446502575 426 TAIQQHRGWVKAEDSPLGGLRLVIWLPLY 454
Cdd:PRK10604 396 SIALAMGGSVNCDESELGGARFSFSWPVW 424
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
188-453 |
1.85e-42 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 155.45 E-value: 1.85e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 188 KPARKLKNAADEVAQGNlrqHPE--LEAGPQEFLAAGASFNQMvtALGRMMTSQQR--LLSDISHELRTPLTRLQLGTAL 263
Cdd:PRK09467 179 RPLVALEHAALQVGKGE---IPPplREYGASEVRSVTRAFNQM--AAGIKQLEDDRtlLMAGVSHDLRTPLTRIRLATEM 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 264 LrrrSGESKEL-ERIETEAQRLDSMINDLLVMSRNQQKnaLVSETIKANQLWSEVldnAAFEAEQmGKSLTVNFPPGPWP 342
Cdd:PRK09467 254 M---SEEDGYLaESINKDIEECNAIIEQFIDYLRTGQE--MPMEMADLNALLGEV---IAAESGY-EREIETALQPGPIE 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 343 LYGNPNALESALENIVRNALRYSHTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDreSGGTGLGLA 422
Cdd:PRK09467 325 VPMNPIAIKRALANLVVNAARYGNGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARG--SSGTGLGLA 402
|
250 260 270
....*....|....*....|....*....|.
gi 446502575 423 IVETAIQQHRGWVKAEDSPLGGLRLVIWLPL 453
Cdd:PRK09467 403 IVKRIVDQHNGKVELGNSEEGGLSARAWLPL 433
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
140-452 |
6.01e-40 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 150.18 E-value: 6.01e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 140 NYQLYLIRPASSSQS--DFINLLFDRPLLLLI---------VTMLVSTPlllwlawslakpARKLKNAADEVAQGNLRQH 208
Cdd:NF040691 167 NYELYLLFPLEDEQStlALVRGTLLLGGLALVvllgliawlVTRQVVAP------------VRSAARTAERFAAGDLSER 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 209 PElEAGPQEFLAAGASFNQMVTALGRMMTS-------QQRLLSDISHELRTPLTRLQLGTALLRRRSGE-----SKELER 276
Cdd:NF040691 235 MP-VKGEDDLARLARSFNQMADSLQRQIRQleelsrlQQRFVSDVSHELRTPLTTIRMAADVIHDSRDDfdpatARSAEL 313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 277 IETEAQRLDSMINDLLVMSR-NQQKNALVSETIKANQLWSEVLDNAAFEAEQMGKSLTVNFPPGPWPLYGNPNALESALE 355
Cdd:NF040691 314 LHTELDRFESLLSDLLEISRfDAGAAELDVEPVDLRPLVRRVVDALRQLAERAGVELRVDAPGTPVVAEVDPRRVERVLR 393
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 356 NIVRNALRYS-HTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVETAIQQHRGW 434
Cdd:NF040691 394 NLVVNAIEHGeGKPVVVTVAQDDTAVAVTVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGW 473
|
330
....*....|....*...
gi 446502575 435 VKAEDSPLGGLRLVIWLP 452
Cdd:NF040691 474 LEAWGRPGQGSQFRLTLP 491
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
229-453 |
1.77e-37 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 141.64 E-value: 1.77e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 229 VTALGRM--MTSQQRLLSDISHELRTPLTRLQLGTALLRRRSGESKE---------LERIETEAQRLDSMINDLLVMSRN 297
Cdd:COG5000 189 ITELLRAerLAAWGELARRIAHEIKNPLTPIQLSAERLRRKLADKLEedredleraLDTIIRQVDRLKRIVDEFLDFARL 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 298 QQknaLVSETIKANQLWSEVLDNAAFEAEQMGKSLTVNFPPGPWPLYGNPNALESALENIVRNALR--YSHTKIEVGFAV 375
Cdd:COG5000 269 PE---PQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEaiEEGGEIEVSTRR 345
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446502575 376 DKDGITITVDDDGPGVSPEDREQIFRPFYRTDEardresGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPL 453
Cdd:COG5000 346 EDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKP------KGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPL 417
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
246-452 |
1.36e-36 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 140.69 E-value: 1.36e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 246 ISHELRTPLTRLQLGTALLRRRSGES------KELERIETEAQRLDSMINDLLVMSRnQQKNALVSETIKANQLWSEVLD 319
Cdd:COG4251 289 ASHDLREPLRKISGFSQLLEEDYGDKldeegrEYLERIRDAAERMQALIDDLLAYSR-VGRQELEFEPVDLNELLEEVLE 367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 320 NAAFEAEQmgKSLTVNFPPGPwPLYGNPNALESALENIVRNALRYSHT----KIEVGFAVDKDGITITVDDDGPGVSPED 395
Cdd:COG4251 368 DLEPRIEE--RGAEIEVGPLP-TVRGDPTLLRQVFQNLISNAIKYSRPgeppRIEIGAEREGGEWVFSVRDNGIGIDPEY 444
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 446502575 396 REQIFRPFYRTDEARDREsgGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLP 452
Cdd:COG4251 445 AEKIFEIFQRLHSRDEYE--GTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
229-433 |
2.07e-36 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 136.57 E-value: 2.07e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 229 VTALGRMMTSQQRLLSDISHELRTPLTRLQ-----LGTALLRRRSGESKELERIETEAQRLDSMINDLLVMSR-----NQ 298
Cdd:TIGR02966 104 VTRLRRLEQMRRDFVANVSHELRTPLTVLRgyletLADGPDEDPEEWNRALEIMLEQSQRMQSLVEDLLTLSRlesaaSP 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 299 QKNalvsETIKANQLWSEVLDNAAFEAEQMGKSLTVNFPPGPWpLYGNPNALESALENIVRNALRYS--HTKIEVGFAVD 376
Cdd:TIGR02966 184 LED----EPVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVD-VLGDEDELRSAFSNLVSNAIKYTpeGGTITVRWRRD 258
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 446502575 377 KDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVETAIQQHRG 433
Cdd:TIGR02966 259 GGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHA 315
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
231-453 |
2.19e-36 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 137.24 E-value: 2.19e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 231 ALGRMMTSqqrllsdISHELRTPLTRLQLGTALLRRRSGESKE-------LERIETEAQRLDSMINDLLVMSRNQQknaL 303
Cdd:COG4191 141 ALGELAAG-------IAHEINNPLAAILGNAELLRRRLEDEPDpeelreaLERILEGAERAAEIVRSLRAFSRRDE---E 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 304 VSETIKANQLWSEVLDNAAFEAEQMGKSLTVNFPPGPWPLYGNPNALESALENIVRNAL----RYSHTKIEVGFAVDKDG 379
Cdd:COG4191 211 EREPVDLNELIDEALELLRPRLKARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIdameEGEGGRITISTRREGDY 290
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446502575 380 ITITVDDDGPGVSPEDREQIFRPFYRTDEardrESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPL 453
Cdd:COG4191 291 VVISVRDNGPGIPPEVLERIFEPFFTTKP----VGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
188-452 |
8.22e-36 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 137.90 E-value: 8.22e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 188 KPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALGRMMTSQQRLLSDISHELRTPLTRL--QLGTALLR 265
Cdd:TIGR01386 190 EPLRRLSAVAARISPESLDQRLDPSRAPAELRELAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLTNLlgQTQVALSQ 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 266 RRSGESKE--LERIETEAQRLDSMINDLLVMSRNQqkNALVSETIKANQLWSEVLDNAA-FE--AEQMGKSLTVNfppGP 340
Cdd:TIGR01386 270 PRTGEEYRevLESNLEELERLSRMVSDMLFLARAD--NGQLALERVRLDLAAELAKVAEyFEplAEERGVRIRVE---GE 344
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 341 WPLYGNPNALESALENIVRNALRYS--HTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTG 418
Cdd:TIGR01386 345 GLVRGDPQMFRRAISNLLSNALRHTpdGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTG 424
|
250 260 270
....*....|....*....|....*....|....
gi 446502575 419 LGLAIVETAIQQHRGWVKAEdSPLGGLRLVIWLP 452
Cdd:TIGR01386 425 LGLAIVRSIMEAHGGRASAE-SPDGKTRFILRFP 457
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
188-452 |
1.17e-35 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 137.27 E-value: 1.17e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 188 KPARKLKNAADEVAQGNLrQHPELEAGPQEFLAAGASFNQMVTALGRMMTSQQRLLSDISHELRTPLTRLQLGTALLRR- 266
Cdd:NF012163 190 APVKRLVEATHRLAAGDY-TTRVTPTSNDELGKLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRAELEAIQDg 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 267 -RSGESKELERIETEAQRLDSMINDL--LVMSRNQQKnALVSETIKANQLWSEVLDNAAFEAEQMGKSLTVNFPPGPWpL 343
Cdd:NF012163 269 iRKFTPESLDSLQAEVGTLTKLVDDLhdLSMSDEGAL-AYQKASVDLVPLLEVEGGAFRERFASAGLELEVSLPDSSL-V 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 344 YGNPNALESALENIVRNALRYSHT--KIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGL 421
Cdd:NF012163 347 FGDRDRLMQLFNNLLENSLRYTDSggSLHISASQRPKEVTLTVADSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGL 426
|
250 260 270
....*....|....*....|....*....|.
gi 446502575 422 AIVETAIQQHRGWVKAEDSPLGGLRLVIWLP 452
Cdd:NF012163 427 AISLNIVQAHGGTLHAAHSPLGGLRIVVTLP 457
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-453 |
2.52e-35 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 126.78 E-value: 2.52e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 350 LESALENIVRNALRYSHTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVETAIQ 429
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVAL 80
|
90 100
....*....|....*....|....
gi 446502575 430 QHRGWVKAEDSPLGGLRLVIWLPL 453
Cdd:cd16939 81 WHGGHVECDDSELGGACFRLTWPR 104
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
236-457 |
3.98e-35 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 133.82 E-value: 3.98e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 236 MTSQQRLLSDISHELRTPLTRLQLGTALLRRRSGESKELE---RIETEAQRLDSMINDLLVMSRNQQknaLVSETIKANQ 312
Cdd:COG3852 132 LAAVGELAAGLAHEIRNPLTGIRGAAQLLERELPDDELREytqLIIEEADRLNNLVDRLLSFSRPRP---PEREPVNLHE 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 313 LWSEVLDNAAFEAEQmGKSLTVNFPPGPWPLYGNPNALESALENIVRNAL-------------RYSHtKIEVGFAVDKDG 379
Cdd:COG3852 209 VLERVLELLRAEAPK-NIRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAeampeggtitirtRVER-QVTLGGLRPRLY 286
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446502575 380 ITITVDDDGPGVSPEDREQIFRPFYRTDEardresGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPLYKRS 457
Cdd:COG3852 287 VRIEVIDNGPGIPEEILDRIFEPFFTTKE------KGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAE 358
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
225-455 |
6.22e-34 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 132.45 E-value: 6.22e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 225 FNQMVTALGRMMTSQQRLLSDISHELRTPLT-------RLQLGtalLRRRSGESkeLERIETEAQRLDSMINDL--LVMS 295
Cdd:PRK10549 226 FNQLASTLEKNEQMRRDFMADISHELRTPLAvlrgeleAIQDG---VRKFTPES--VASLQAEVGTLTKLVDDLhqLSLS 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 296 rnqQKNALV--SETIKANQLwsevLDNAA------FEAEQMgkSLTVNFPPGPwPLYGNPNALESALENIVRNALRY--S 365
Cdd:PRK10549 301 ---DEGALAyrKTPVDLVPL----LEVAGgafrerFASRGL--TLQLSLPDSA-TVFGDPDRLMQLFNNLLENSLRYtdS 370
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 366 HTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGL 445
Cdd:PRK10549 371 GGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGV 450
|
250
....*....|
gi 446502575 446 RLVIWLPLYK 455
Cdd:PRK10549 451 SITVELPLER 460
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
345-453 |
4.56e-32 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 118.13 E-value: 4.56e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 345 GNPNALESALENIVRNALRYSH--TKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEaRDRESGGTGLGLA 422
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPegGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|.
gi 446502575 423 IVETAIQQHRGWVKAEDSPLGGLRLVIWLPL 453
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
350-451 |
1.02e-31 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 116.93 E-value: 1.02e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 350 LESALENIVRNALRYS--HTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEArdRESGGTGLGLAIVETA 427
Cdd:cd00075 1 LEQVLSNLLDNALKYSppGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKS--REGGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 446502575 428 IQQHRGWVKAEDSPLGGLRLVIWL 451
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-452 |
1.33e-28 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 108.70 E-value: 1.33e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 346 NPNALESALENIVRNALRYSHT--KIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAI 423
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTggKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 446502575 424 VETAIQQHRGWVKAEDSPLGGLRLVIWLP 452
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
188-452 |
1.37e-27 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 114.87 E-value: 1.37e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 188 KPARKLKNAADEVAQGNLRQHPELEAGPQEFLAAGASFNQMVTALGRMMTSQQRLLSDISHELRTPLTRL--QLGTALLR 265
Cdd:PRK09835 211 APIRSVSRQIQNITSKDLDVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLitQTEIALSQ 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 266 RRSgeSKELERI----ETEAQRLDSMINDLLVMSR--NQQknaLVSETiKANQLWSEVLDNAAF-EAEQMGKSLTVNFPP 338
Cdd:PRK09835 291 SRS--QKELEDVlysnLEELTRMAKMVSDMLFLAQadNNQ---LIPEK-KMLDLADEVGKVFDFfEAWAEERGVELRFVG 364
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 339 GPWPLYGNPNALESALENIVRNALRYSHT--KIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGG 416
Cdd:PRK09835 365 DPCQVAGDPLMLRRAISNLLSNALRYTPAgeAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEG 444
|
250 260 270
....*....|....*....|....*....|....*.
gi 446502575 417 TGLGLAIVETAIQQHRGWVKAEdSPLGGLRLVIWLP 452
Cdd:PRK09835 445 SGIGLAIVKSIVVAHKGTVAVT-SDARGTRFVISLP 479
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
189-453 |
3.01e-27 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 113.79 E-value: 3.01e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 189 PARKLKNAADEVAQGNLRQHPELeaGPQEFLAAGASFNQMVTAL-GRMMTSQ--QRLlsdiSHELRTPLTRLqLGTALLR 265
Cdd:PRK11100 209 SIRRLTRYADAVTEGKPVPLPKL--GSSELRELAQALESMRVKLeGKAYVEQyvQTL----THELKSPLAAI-RGAAELL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 266 RRSGESKELER----IETEAQRLDSMINDLLVMSRNQQKNAL-VSETIKANQLWSEVLDNAAFEAEQmgKSLTVNFPPGP 340
Cdd:PRK11100 282 QEDPPPEDRARftgnILTQSARLQQLIDRLLELARLEQRQELeVLEPVALAALLEELVEAREAQAAA--KGITLRLRPDD 359
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 341 WPLYGNPNALESALENIVRNALRYSHTK--IEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFY---RTDEARDresg 415
Cdd:PRK11100 360 ARVLGDPFLLRQALGNLLDNAIDFSPEGgtITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYslpRPANGRK---- 435
|
250 260 270
....*....|....*....|....*....|....*...
gi 446502575 416 GTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPL 453
Cdd:PRK11100 436 STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
345-453 |
1.56e-26 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 103.22 E-value: 1.56e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 345 GNPNALESALENIVRNALRYSH--TKIEVGFAvDKDGITITVDDDGPGVSPEDREQIFRPFYRTDearDRESGGTGLGLA 422
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAkaGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTAD---KRGGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|.
gi 446502575 423 IVETAIQQHRGWVKAEDSPLGGLRLVIWLPL 453
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGGTTVTLTLPL 107
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
229-452 |
4.54e-25 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 106.63 E-value: 4.54e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 229 VTALGRMMTSQQRLLSDISHELRTPLTRLQLGTALLRRRSGES----KELERIETEAQRLDSMINDLLVMSRNQQKNALV 304
Cdd:PRK11006 194 VTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGalreKALHTMREQTQRMEGLVKQLLTLSKIEAAPTID 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 305 SETIKANQLWSEVLDNAAFEAEQMGKSLTVNFPPGpWPLYGNPNALESALENIVRNALRYSH--TKIEVGFAVDKDGITI 382
Cdd:PRK11006 274 LNEKVDVPMMLRVLEREAQTLSQGKHTITFEVDNS-LKVFGNEDQLRSAISNLVYNAVNHTPegTHITVRWQRVPQGAEF 352
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 383 TVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLP 452
Cdd:PRK11006 353 SVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
216-452 |
5.39e-25 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 105.44 E-value: 5.39e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 216 QEFLAAGASFNQMVTALGRMMtSQQRLL-SDISHELRTPLTRLQLGTALLRRRSG-ESKELerieteAQRLDSM---IND 290
Cdd:PRK10755 114 LEIEAVTSALNQLVSRLTSTL-DQERLFtADVAHELRTPLAGIRLHLELLEKQHHiDVAPL------IARLDQMmhtVEQ 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 291 LLVMSR--------NQQKNALVSETIKANQlwsevlDNAAFEAEQMGKSLTVNFPPGPWPLYGNPNALESALENIVRNAL 362
Cdd:PRK10755 187 LLQLARagqsfssgHYQTVKLLEDVILPSQ------DELSEMLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAH 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 363 RYS--HTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTdearDRESGGTGLGLAIVETAIQQHRGWVKAED- 439
Cdd:PRK10755 261 RYSpeGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRM----DSRYGGIGLGLSIVSRITQLHHGQFFLQNr 336
|
250
....*....|...
gi 446502575 440 SPLGGLRLVIWLP 452
Cdd:PRK10755 337 QERSGTRAWVWLP 349
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-452 |
5.92e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 98.29 E-value: 5.92e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 350 LESALENIVRNALRYSHTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDreSGGTGLGLAIVETAIQ 429
Cdd:cd16950 1 LKRVLSNLVDNALRYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRISD 78
|
90 100
....*....|....*....|...
gi 446502575 430 QHRGWVKAEDSPLGGLRLVIWLP 452
Cdd:cd16950 79 AHGGSLTLANRAGGGLCARIELP 101
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
329-449 |
1.52e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 98.47 E-value: 1.52e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 329 GKSLTVNFPPG-PWPlyGNPNALESALENIVRNALRYSHTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTD 407
Cdd:cd16954 18 GVSISLDISPElRFP--GERNDLMELLGNLLDNACKWCLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLD 95
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 446502575 408 EARDresgGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVI 449
Cdd:cd16954 96 EQRP----GQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEV 133
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
188-440 |
6.77e-22 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 96.60 E-value: 6.77e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 188 KPARKLKNAADEVAQGNLRQHPELEAG-PQEFLAAGASFNQMVTALGRMMTSQQRLLSDISHELRTPLT----RLQ---- 258
Cdd:NF012226 86 VPINFLADAAKKISQGDLSARAEDSQIhSAEISELMHNFNDMAQKLESSVKNAQVWNAAIAHELRTPITilqgRLQgild 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 259 --------LGTALLRRRSGESKELERIETeaqrldsmindlLVMSRNQQKNaLVSETIKANQLWSEVLDnaAFEAEQMGK 330
Cdd:NF012226 166 gvfepdpaLFKSLLNQVEGLSHLVEDLRT------------LSLVENQQLR-LNYESVDLKDSIEKVLK--MFEDRLEQA 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 331 SLTVNFPPGPWPLYGNPNALESALENIVRNALRYSHT-KIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEA 409
Cdd:NF012226 231 QLTIVLNLTATPVFCDRRRIEQVLIALIDNAIRYANAgKLKISSSVIQDDWILQIEDEGPGIAEEYQQDLFNPFFRLEQS 310
|
250 260 270
....*....|....*....|....*....|.
gi 446502575 410 RDRESGGTGLGLAIVETAIQQHRGWVKAEDS 440
Cdd:NF012226 311 RNKEFGGTGLGLAVVHAIVIAHKGSIEYSNS 341
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
241-438 |
2.44e-21 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 96.20 E-value: 2.44e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 241 RLLSDISHELRTPLTRL----QLgtaLLRRRSGESKE-LERIETEAQRLDSMINDLLVMSRNQqknALVSETIKANQLWS 315
Cdd:COG5809 272 ELAAGIAHEIRNPLTSLkgfiQL---LKDTIDEEQKTyLDIMLSELDRIESIISEFLVLAKPQ---AIKYEPKDLNTLIE 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 316 EVLDnaAFEAE------QMGKSLTVNFPPgpwpLYGNPNALESALENIVRNAlryshtkIEV----G------FAVDKDG 379
Cdd:COG5809 346 EVIP--LLQPQallknvQIELELEDDIPD----ILGDENQLKQVFINLLKNA-------IEAmpegGnitietKAEDDDK 412
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 446502575 380 ITITVDDDGPGVSPEDREQIFRPFYRTDEardresGGTGLGLAIVETAIQQHRGWVKAE 438
Cdd:COG5809 413 VVISVTDEGCGIPEERLKKLGEPFYTTKE------KGTGLGLMVSYKIIEEHGGKITVE 465
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
242-453 |
3.43e-21 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 96.64 E-value: 3.43e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 242 LLSDISHELRTPLTRLqLGTA------LLRRRSGESKELERIETEAQRLDSMINDLLVMSRNQqknalvSETIKANQLW- 314
Cdd:PRK10490 667 LLAALSHDLRTPLTVL-FGQAeiltldLASEGSPHARQASEIRQQVLNTTRLVNNLLDMARIQ------SGGFNLRKEWl 739
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 315 --SEVLDNAAFEAEQM--GKSLTVNFPPGPWPLYGNPNALESALENIVRNALRYSHTKIEVGF--AVDKDGITITVDDDG 388
Cdd:PRK10490 740 tlEEVVGSALQMLEPGlsGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIdaHVEGERLQLDVWDNG 819
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446502575 389 PGVSPEDREQIFRPFYRTDeardRESG--GTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPL 453
Cdd:PRK10490 820 PGIPPGQEQLIFDKFARGN----KESAipGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPL 882
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
215-445 |
1.20e-20 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 93.95 E-value: 1.20e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 215 PQEFLAAGASFNQMVTALGRMMTSQQRLLSDISHELRTPLTRLQLGT--ALLRRRSGESKE--LERIETEAQRLDSMIND 290
Cdd:PRK10337 213 PSEVRPLVEALNQLFARTHAMMVRERRFTSDAAHELRSPLAALKVQTevAQLSDDDPQARKkaLLQLHAGIDRATRLVDQ 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 291 LLVMSRNQQKNALvsETIKANQlWSEVLDNAAFE----AEQMGKSLTVNFPPGPWPLYGNPNALESALENIVRNALRYSH 366
Cdd:PRK10337 293 LLTLSRLDSLDNL--QDVAEIP-LEDLLQSAVMDiyhtAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSP 369
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446502575 367 TKIEVGFAVDKDGITITvdDDGPGVSPEDREQIFRPFYRTDearDRESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGL 445
Cdd:PRK10337 370 QGSVVDVTLNARNFTVR--DNGPGVTPEALARIGERFYRPP---GQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGGF 443
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
224-452 |
2.30e-20 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 94.04 E-value: 2.30e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 224 SFNQMVTALGRMMTSQQRLLSDISHELRTP-------LTRLQLGTAllrrrSGESKE-LERIETEAQRLDSMINDLLVMS 295
Cdd:TIGR03785 470 SFAQMVARLRQYTHYLENMSSRLSHELRTPvavvrssLENLELQAL-----EQEKQKyLERAREGTERLSMILNNMSEAT 544
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 296 RNQQknALVS---ETIKANQLWSEVLdnAAFEAEQMGKSLTVNFPPGPWPLYGNPNALESALENIVRNALRYSH--TKIE 370
Cdd:TIGR03785 545 RLEQ--AIQSaevEDFDLSEVLSGCM--QGYQMTYPPQRFELNIPETPLVMRGSPELIAQMLDKLVDNAREFSPedGLIE 620
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 371 VGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVETAIQQHRGWVKAEDSPLG-GLRLVI 449
Cdd:TIGR03785 621 VGLSQNKSHALLTVSNEGPPLPEDMGEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRQQNdGVVFRI 700
|
...
gi 446502575 450 WLP 452
Cdd:TIGR03785 701 SLP 703
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
206-447 |
5.19e-20 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 92.39 E-value: 5.19e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 206 RQHPELEAGPQEFL--AAGASFNQMVTALGRMMTSQ-QRL------LSDISHELRTPLTRLQlgTALLRRRSG-----ES 271
Cdd:PRK10815 224 KQVRELEEGEREQLdpNPPRELTSLVRNLNRLLKNErERYtkyrttLTDLTHSLKTPLAVLQ--STLRSLRSGkqmsvEQ 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 272 KE---LERIETEAQRLD------SMINDLLVMSRNQQK-----NALVSETIKANQlwsevldnaafeaeQMGKSLTVNFP 337
Cdd:PRK10815 302 AEpimLEQISRISQQIGyylhraSMRSEHNLLSRELHSvapllDNLTSALNKVYQ--------------RKGVNITLDIS 367
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 338 PgPWPLYGNPNALESALENIVRNALRYSHTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDresgGT 417
Cdd:PRK10815 368 P-EITFVGEKNDFMEVMGNVLDNACKYCLEFVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQ 442
|
250 260 270
....*....|....*....|....*....|
gi 446502575 418 GLGLAIVETAIQQHRGWVKAEDSPLGGLRL 447
Cdd:PRK10815 443 GLGLSVAREITEQYEGKISAGDSPLGGARM 472
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
236-453 |
1.23e-19 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 90.29 E-value: 1.23e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 236 MTSQQRLLSDISHELRTpltRLQLGTALLRrrSGESKELER-IETEAQRLDSMINDLLVMSRNQQKNALVSEtiKANqlw 314
Cdd:COG3290 186 VKELAEALRAQRHDFRN---HLHTISGLLQ--LGEYDEALEyIDEISEELQELIDSLLSRIGNPVLAALLLG--KAA--- 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 315 sevldnaafEAEQMGKSLTVNFPPGPWPLYGNPNALESALENIVRNALRY------SHTKIEVGFAVDKDGITITVDDDG 388
Cdd:COG3290 256 ---------RARERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIEAveklpeEERRVELSIRDDGDELVIEVEDSG 326
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446502575 389 PGVSPEDREQIFRPFYRTdeardRESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPL 453
Cdd:COG3290 327 PGIPEELLEKIFERGFST-----KLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPK 386
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
229-453 |
6.42e-19 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 89.26 E-value: 6.42e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 229 VTALGRMMTSQQR---------LLSDISHELRTPLTRLQLGTALLRR---RSGESKELERIETEAQRLDSMINDLLVMSR 296
Cdd:PRK11360 371 LTERKRLQRRVARqerlaalgeLVAGVAHEIRNPLTAIRGYVQIWRQqtsDPPSQEYLSVVLREVDRLNKVIDQLLEFSR 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 297 -----NQQK--NALVSETIKANQLwSEVLDNAAFEAEqmgksLTVNFPPgpwpLYGNPNALESALENIVRNALRYSHT-- 367
Cdd:PRK11360 451 presqWQPVslNALVEEVLQLFQT-AGVQARVDFETE-----LDNELPP----IWADPELLKQVLLNILINAVQAISArg 520
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 368 KIEVGFAVDKDG-ITITVDDDGPGVSPEDREQIFRPFYRTdeardrESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLR 446
Cdd:PRK11360 521 KIRIRTWQYSDGqVAVSIEDNGCGIDPELLKKIFDPFFTT------KAKGTGLGLALSQRIINAHGGDIEVESEPGVGTT 594
|
....*..
gi 446502575 447 LVIWLPL 453
Cdd:PRK11360 595 FTLYLPI 601
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
243-438 |
2.29e-18 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 88.30 E-value: 2.29e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 243 LSDISHELRTPLTRLqLGTALLRRRSG----ESKELERIETEAQRLDSMINDLLVMSRNQQKNALVSET-IKANQLWSEV 317
Cdd:TIGR02956 468 LATMSHEIRTPLNGI-LGTLELLGDTGltsqQQQYLQVINRSGESLLDILNDILDYSKIEAGHLSISPRpFDLNALLDDV 546
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 318 LDNAAFEAEQMGKSLTVNFPPG-PWPLYGNPNALESALENIVRNALRYSHT---KIEVGFAVDKDgITITVDDDGPGVSP 393
Cdd:TIGR02956 547 HHLMVSRAQLKGIQLRLNIPEQlPNWWQGDGPRIRQVLINLVGNAIKFTDRgsvVLRVSLNDDSS-LLFEVEDTGCGIAE 625
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 446502575 394 EDREQIFRPFYRTDEArdRESGGTGLGLAIVETAIQQHRG--WVKAE 438
Cdd:TIGR02956 626 EEQATLFDAFTQADGR--RRSGGTGLGLAISQRLVEAMDGelGVESE 670
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
242-453 |
3.35e-18 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 86.76 E-value: 3.35e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 242 LLSDISHELRTPLTRLQ-LGTALLRR--RSGESKEL-ERIETEAQRLDSMINDLLVMSRNQQknaLVSETIKANQLWSEV 317
Cdd:PRK10364 240 LAAGVAHEIRNPLSSIKgLAKYFAERapAGGEAHQLaQVMAKEADRLNRVVSELLELVKPTH---LALQAVDLNDLINHS 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 318 LDNAAFEAEQMGKSLTVNFPPGPWPLYGNPNALESALENIVRNALRY--SHTKIEVGFAVDKDGITITVDDDGPGVSPED 395
Cdd:PRK10364 317 LQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAigQHGVISVTASESGAGVKISVTDSGKGIAADQ 396
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 446502575 396 REQIFRPFYRTdeardrESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPL 453
Cdd:PRK10364 397 LEAIFTPYFTT------KAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPV 448
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-451 |
4.72e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 79.76 E-value: 4.72e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 345 GNPNALESALENIVRNALRYS--HTKIEVGFAVDkDGITITVDDDGPGVSPEDREQIFRPFYRTDEardRESGGTGLGLA 422
Cdd:cd16940 9 GDALLLFLLLRNLVDNAVRYSpqGSRVEIKLSAD-DGAVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGLGLS 84
|
90 100
....*....|....*....|....*....
gi 446502575 423 IVETAIQQHRGWVKAEDSPLGGLRLVIWL 451
Cdd:cd16940 85 IVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-452 |
5.44e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 79.17 E-value: 5.44e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 350 LESALENIVRNALRYS--HTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVETA 427
Cdd:cd16952 1 LRSAFSNLVSNAVKYTppSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*
gi 446502575 428 IQQHRGWVKAEDSPLGGLRLVIWLP 452
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFP 105
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-452 |
2.35e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 77.37 E-value: 2.35e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 350 LESALENIVRNALRYSHTK----IEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEarDRESGGTGLGLAIVE 425
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrpprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 446502575 426 TAIQQHRGWVKAEDSPLGGLRLVIWLP 452
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
246-453 |
5.00e-16 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 80.16 E-value: 5.00e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 246 ISHELRTPLTR----LQLgtaLLRRRSGESKELERIETEAQRLDSMINDLLVMSRNQqknALVSETIKANQLWSEV---- 317
Cdd:COG5805 294 IAHEIRNPLTSikgfLQL---LQPGIEDKEEYFDIMLSELDRIESIISEFLALAKPQ---AVNKEKENINELIQDVvtll 367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 318 -----LDNAAFEAEQMGKSLTVnfppgpwplYGNPNALESALENIVRNALRY--SHTKIEVGFAVDKDGITITVDDDGPG 390
Cdd:COG5805 368 eteaiLHNIQIRLELLDEDPFI---------YCDENQIKQVFINLIKNAIEAmpNGGTITIHTEEEDNSVIIRVIDEGIG 438
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446502575 391 VSPEDREQIFRPFYRTDEArdresgGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPL 453
Cdd:COG5805 439 IPEERLKKLGEPFFTTKEK------GTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
346-452 |
5.03e-16 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 73.68 E-value: 5.03e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 346 NPNALESALENIVRNALRYSHTKIEVGFAVDK---DGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLA 422
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKfrlNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 446502575 423 IVETAIQQHRGWVKAEDSPLGGLRLVIWLP 452
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-450 |
9.50e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 72.88 E-value: 9.50e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 346 NPNALESALENIVRNALRYSHTKIEVGFAV--DKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDreSGG-TGLGLA 422
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIydEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRR--SGGhYGMGLY 78
|
90 100
....*....|....*....|....*...
gi 446502575 423 IVETAIQQHRGWVKAEDSPLGGLRLVIW 450
Cdd:cd16975 79 IAKNLVEKHGGSLIIENSQKGGAEVTVK 106
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
243-423 |
3.45e-15 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 78.14 E-value: 3.45e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 243 LSDISHELRTPLTRLQLGTALLRRRSGESKELERIETEAQ---RLDSMINDLLVMSRnqqknalvsetIKANQL------ 313
Cdd:PRK15347 402 LTTISHEIRTPLNGVLGALELLQNTPLTAEQMDLADTARQctlSLLAIINNLLDFSR-----------IESGQMtlslee 470
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 314 --WSEVLDNAAFEAEQMG--KSLT----VNfPPGPWPLYGNPNALESALENIVRNALRY-SHTKIEVGFAVDKDGITITV 384
Cdd:PRK15347 471 taLLPLLDQAMLTIQGPAqsKSLTlrtfVG-AHVPLYLHLDSLRLRQILVNLLGNAVKFtETGGIRLRVKRHEQQLCFTV 549
|
170 180 190
....*....|....*....|....*....|....*....
gi 446502575 385 DDDGPGVSPEDREQIFRPFYRTDEardrESGGTGLGLAI 423
Cdd:PRK15347 550 EDTGCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTI 584
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
347-453 |
4.73e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 70.91 E-value: 4.73e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 347 PNALESALENIVRNALRY--SHTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDresgGTGLGLAIV 424
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAmeGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLS 76
|
90 100
....*....|....*....|....*....
gi 446502575 425 ETAIQQHRGWVKAEDSPLGGLRLVIWLPL 453
Cdd:cd16943 77 YRIIQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
348-452 |
8.00e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 70.01 E-value: 8.00e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 348 NALESALenivrnALRYSHTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDResggtGLGLAIVETA 427
Cdd:cd16915 11 NALDALA------ATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGER-----GIGLALVRQS 79
|
90 100
....*....|....*....|....*
gi 446502575 428 IQQHRGWVKAEDSPLGGLRLVIWLP 452
Cdd:cd16915 80 VERLGGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
354-438 |
1.10e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 69.83 E-value: 1.10e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 354 LENIVRNALRYShTKIEVGFAVDKDG-------ITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVET 426
Cdd:cd16922 5 LLNLLGNAIKFT-EEGEVTLRVSLEEeeedgvqLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAISKK 83
|
90
....*....|....
gi 446502575 427 AIQQHRG--WVKAE 438
Cdd:cd16922 84 LVELMGGdiSVESE 97
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
246-454 |
1.14e-14 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 75.67 E-value: 1.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 246 ISHELRTPLT--R--LQLgtaLLRRRSGESKELERIET---EAQRLDSMINDLLVMSRNQQKNalvSETIKANQLWSEVL 318
Cdd:COG5806 208 IAHEVRNPLTvvRgfIQL---LQEPELSDEKRKQYIRIaleELDRAEAIITDYLTFAKPQPEK---LEKIDVSEELEHVI 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 319 DNAAFEAEQMGKSLTVNFPPgPWPLYGNPNALESALENIVRNAlryshtkIE---------VGFAVDKDGITITVDDDGP 389
Cdd:COG5806 282 DVLSPYANMNNVEIQTELEP-GLYIEGDRQKLQQCLINIIKNG-------IEampnggtltIDVSIDKNKVIISIKDTGV 353
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446502575 390 GVSPEDREQIFRPFYRTDEArdresgGTGLGLAIVETAIQQHRGWVKAEdSPLG-GLRLVIWLPLY 454
Cdd:COG5806 354 GMTKEQLERLGEPYFSTKEK------GTGLGTMVSYRIIEAMNGTIRVE-SEVGkGTTFTITLPLA 412
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-438 |
1.79e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 68.95 E-value: 1.79e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 350 LESALENIVRNALRYS--HTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDreSGGTGLGLAIVETA 427
Cdd:cd16923 1 LQRVFSNLLSNAIKYSpeNTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRN--TEGAGLGLSIAKAI 78
|
90
....*....|.
gi 446502575 428 IQQHRGWVKAE 438
Cdd:cd16923 79 IELHGGSASAE 89
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
236-296 |
2.81e-14 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 67.24 E-value: 2.81e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446502575 236 MTSQQRLLSDISHELRTPLTRLQLGTALLRRRSGESKE----LERIETEAQRLDSMINDLLVMSR 296
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEqreyLERIREEAERLLRLINDLLDLSR 65
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
238-299 |
7.89e-14 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 66.08 E-value: 7.89e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446502575 238 SQQRLLSDISHELRTPLTRLQLGTALLRRR--SGESKE-LERIETEAQRLDSMINDLLVMSRNQQ 299
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEklDEEQREyLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
238-299 |
2.32e-13 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 64.89 E-value: 2.32e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446502575 238 SQQRLLSDISHELRTPLTRLQLGTALLRRRSGESKE---LERIETEAQRLDSMINDLLVMSRNQQ 299
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQreyLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-452 |
2.79e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 65.88 E-value: 2.79e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 350 LESALENIVRNAL--------------RYSHtKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEardresG 415
Cdd:cd16918 1 LIQVFLNLVRNAAqalagsggeiilrtRTQR-QVTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPMVSGRE------N 73
|
90 100 110
....*....|....*....|....*....|....*..
gi 446502575 416 GTGLGLAIVETAIQQHRGWVKAEDSPlGGLRLVIWLP 452
Cdd:cd16918 74 GTGLGLAIAQNIVSQHGGVIECDSQP-GHTVFSVSLP 109
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
242-453 |
4.53e-13 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 71.63 E-value: 4.53e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 242 LLSDISHE----LRTPLTRLQLGTALLRRRSGESKELERIETEAQRLDSMINDLLVMSRNQQK-------NALVSETikA 310
Cdd:PRK13837 453 LASGIAHNfnniLGAILGYAEMALNKLARHSRAARYIDEIISAGARARLIIDQILAFGRKGERntkpfdlSELVTEI--A 530
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 311 NQLWSEVLDNAAFEAEQMGKSLTVNfppgpwplyGNPNALESALENIVRNALRYSHTKIEVGFAVDK------------- 377
Cdd:PRK13837 531 PLLRVSLPPGVELDFDQDQEPAVVE---------GNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRaklrapkvlshgv 601
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 378 ----DGITITVDDDGPGVSPEDREQIFRPFYRTdeardrESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPL 453
Cdd:PRK13837 602 lppgRYVLLRVSDTGAGIDEAVLPHIFEPFFTT------RAGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPP 675
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
238-453 |
2.73e-12 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 68.99 E-value: 2.73e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 238 SQQRLLSDISHELRTPLTRLqLGTALLRRRSGESKElERIET------EAQRLDSMINDLLVMSRNQQKNalvsetIKAN 311
Cdd:PRK09959 711 AKSQFLATMSHEIRTPISSI-MGFLELLSGSGLSKE-QRVEAislayaTGQSLLGLIGEILDVDKIESGN------YQLQ 782
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 312 QLWSEV---LDNA--AFEAEQMGKSLTVNFP---PGPWPLYGNPNALESALENIVRNALRYS---HTKIEVGFAVDKDG- 379
Cdd:PRK09959 783 PQWVDIptlVQNTchSFGAIAASKSIALSCSstfPDHYLVKIDPQAFKQVLSNLLSNALKFTtegAVKITTSLGHIDDNh 862
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446502575 380 --ITITVDDDGPGVSPEDREQIFRPFYRTDEArdRESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPL 453
Cdd:PRK09959 863 avIKMTIMDSGSGLSQEEQQQLFKRYSQTSAG--RQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPV 936
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-452 |
3.31e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 62.80 E-value: 3.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 350 LESALENIVRNALR-YSHTKIE-----VGFAV-DKDGITITVDDDGPGVSPEDREQIFRPFYRTdeardrESGGTGLGLA 422
Cdd:cd16920 1 IQQVLINLVRNGIEaMSEGGCErreltIRTSPaDDRAVTISVKDTGPGIAEEVAGQLFDPFYTT------KSEGLGMGLS 74
|
90 100 110
....*....|....*....|....*....|
gi 446502575 423 IVETAIQQHRGWVKAEDSPLGGLRLVIWLP 452
Cdd:cd16920 75 ICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
224-455 |
4.56e-12 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 68.46 E-value: 4.56e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 224 SFNQMVTALGRMMTSQQRLLSDISHELRTPLTRLQLGTALLRrrsgeSKELERietEAQRLDSMINDllvmsrnqqKNAL 303
Cdd:PRK10841 432 SLQEMAQAAEQASQSKSMFLATVSHELRTPLYGIIGNLDLLQ-----TKELPK---GVDRLVTAMNN---------SSSL 494
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 304 VSETIkanqlwSEVLDNAAFEAEQMG-------------------------KSLTVN-F--PPGPWPLYGNPNALESALE 355
Cdd:PRK10841 495 LLKII------SDILDFSKIESEQLKieprefsprevinhitanylplvvkKRLGLYcFiePDVPVALNGDPMRLQQVIS 568
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 356 NIVRNALRYSHTK-IEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVETAIQQHRGW 434
Cdd:PRK10841 569 NLLSNAIKFTDTGcIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGD 648
|
250 260
....*....|....*....|.
gi 446502575 435 VKAEDSPLGGLRLVIWLPLYK 455
Cdd:PRK10841 649 ISVDSEPGMGSQFTIRIPLYG 669
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
342-441 |
4.72e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 62.92 E-value: 4.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 342 PLYGNPN--ALESALENIVRNALRYSHTKIEVGFAV--DKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGT 417
Cdd:cd16947 11 PIYANANteALQRILKNLISNAIKYGSDGKFLGMTLreDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGN 90
|
90 100
....*....|....*....|....
gi 446502575 418 GLGLAIVETAIQQHRGWVKAEDSP 441
Cdd:cd16947 91 GLGLTITKRLAESMGGSIYVNSKP 114
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
243-453 |
1.32e-11 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 66.85 E-value: 1.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 243 LSDISHELRTPLTRLqLGTALL---RRRSGESKE-LERIETEAQRLDSMINDLLVMSRNQQKNALVS---ETIKANQLWS 315
Cdd:PRK11466 448 LAAMSHEIRTPLYGI-LGTAQLladNPALNAQRDdLRAITDSGESLLTILNDILDYSAIEAGGKNVSvsdEPFEPRPLLE 526
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 316 EVLDNAAFEAEQMGKSLTVNFPPG-PWPLYGNPNALESALENIVRNALRYSHT-KIEVGFAVDKDGITITVDDDGPGVSP 393
Cdd:PRK11466 527 STLQLMSGRVKGRPIRLATDIADDlPTALMGDPRRIRQVITNLLSNALRFTDEgSIVLRSRTDGEQWLVEVEDSGCGIDP 606
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 394 EDREQIFRPFYRTDEARdresGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPL 453
Cdd:PRK11466 607 AKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPL 662
|
|
| nifL_nitrog |
TIGR02938 |
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ... |
231-453 |
3.25e-11 |
|
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]
Pssm-ID: 131984 [Multi-domain] Cd Length: 494 Bit Score: 65.31 E-value: 3.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 231 ALGRMMTSQQRL------LSDISHELRTPLTRLQLGTALLRRRSGESKELERIETEAQRLDSMINDLLVMSRN-QQKNAL 303
Cdd:TIGR02938 262 ALQALMAEEERLeairetLSAAIHRLQGPMNLISAAISVLQRRGDDAGNPASAAMLQQALSAGREHMEALRQViPQSPQE 341
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 304 VSETIKANQLWSEVLDnaAFEAEQMGKSLTVNFPPG---PWpLYGNPNALESALENIVRNAL------RYSHTKIEVGFA 374
Cdd:TIGR02938 342 IVVPVNLNQILRDVIT--LSTPRLLAAGIVVDWQPAatlPA-ILGRELQLRSLFKALVDNAIeamnikGWKRRELSITTA 418
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446502575 375 VDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDResgGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPL 453
Cdd:TIGR02938 419 LNGDLIVVSILDSGPGIPQDLRYKVFEPFFTTKGGSRK---HIGMGLSVAQEIVADHGGIIDLDDDYSEGCRIIVEFRV 494
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
238-443 |
1.42e-10 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 62.66 E-value: 1.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 238 SQQRLLSDISHELRTPLT-------RLQLG---TALLRRRSGESKELERIETEAQRLDSMINDLLVMSR--------NQQ 299
Cdd:PRK09303 150 FKDRVLAMLAHDLRTPLTaaslaleTLELGqidEDTELKPALIEQLQDQARRQLEEIERLITDLLEVGRtrwealrfNPQ 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 300 KNALVSetikanqLWSEVLDNaaFEAEQMGKSLTVN--FPPGPWPLYGNPNALESALENIVRNALRYS--HTKIEVGfAV 375
Cdd:PRK09303 230 KLDLGS-------LCQEVILE--LEKRWLAKSLEIQtdIPSDLPSVYADQERIRQVLLNLLDNAIKYTpeGGTITLS-ML 299
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446502575 376 DKDG--ITITVDDDGPGVSPEDREQIFRPFYRTDeaRDRESGGTGLGLAIVETAIQQHRG--WVkaeDSPLG 443
Cdd:PRK09303 300 HRTTqkVQVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGqiWV---DSEPG 366
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-452 |
1.69e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 57.93 E-value: 1.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 349 ALESALENIVRNALR----YSHTKIEVGFAVDKD---GITITVDDDGPGVSPEDREQIFRPFYRTDEArdresgGTGLGL 421
Cdd:cd16944 4 QISQVLTNILKNAAEaiegRPSDVGEVRIRVEADqdgRIVLIVCDNGKGFPREMRHRATEPYVTTRPK------GTGLGL 77
|
90 100 110
....*....|....*....|....*....|.
gi 446502575 422 AIVETAIQQHRGWVKAEDSPLGGLRLVIWLP 452
Cdd:cd16944 78 AIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
243-430 |
1.78e-10 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 63.33 E-value: 1.78e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 243 LSDISHELRTPL------TRLQLGTALlrrRSGESKELERIETEAQRLDSMINDLLVMSRnQQKNALVSETIKANqlWSE 316
Cdd:PRK11107 297 LANMSHELRTPLngvigfTRQTLKTPL---TPTQRDYLQTIERSANNLLAIINDILDFSK-LEAGKLVLENIPFS--LRE 370
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 317 VLDNA----AFEAEQMGKSLTVNFPPG-PWPLYGNPNALESALENIVRNALRYS-----HTKIEVGfAVDKDGITITVD- 385
Cdd:PRK11107 371 TLDEVvtllAHSAHEKGLELTLNIDPDvPDNVIGDPLRLQQIITNLVGNAIKFTesgniDILVELR-ALSNTKVQLEVQi 449
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 446502575 386 -DDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVETAIQQ 430
Cdd:PRK11107 450 rDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNE 495
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-445 |
5.74e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 56.31 E-value: 5.74e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 346 NPNALESALENIVRNALRYSHTKIEVGFA--VDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGgTGLGLAI 423
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQleADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKS-TGLGLAF 79
|
90 100
....*....|....*....|..
gi 446502575 424 VETAIQQHRGWVKAEDSPLGGL 445
Cdd:cd16945 80 VQEVAQLHGGRITLRNRPDGVL 101
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
350-452 |
9.29e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 56.23 E-value: 9.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 350 LESALENIVRNA-----------LRYSHTKIEVGFAVDKDG------ITITVDDDGPGVSPEDREQIFRPFYRTDEardr 412
Cdd:cd16919 1 LELAILNLAVNArdampeggrltIETSNQRVDADYALNYRDlipgnyVCLEVSDTGSGMPAEVLRRAFEPFFTTKE---- 76
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 446502575 413 ESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLP 452
Cdd:cd16919 77 VGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-452 |
1.19e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 55.66 E-value: 1.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 350 LESALENIVRNALRYS---HTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESGGTGLGLAIVET 426
Cdd:cd16953 1 LGQVLRNLIGNAISFSppdTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQ 80
|
90 100 110
....*....|....*....|....*....|
gi 446502575 427 AIQQHRGWVKAED----SPLGGLRLVIWLP 452
Cdd:cd16953 81 IIEAHGGISVAENhnqpGQVIGARFTVQLP 110
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
343-453 |
1.67e-09 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 59.32 E-value: 1.67e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 343 LYGNPNALESALENIVRNALRyshtkievgfAVDKDGITIT-----------------------VDDDGPGVSPEDREQI 399
Cdd:PRK11073 231 LAHDPDQIEQVLLNIVRNALQ----------ALGPEGGTITlrtrtafqltlhgeryrlaaridIEDNGPGIPPHLQDTL 300
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 446502575 400 FRPFYRTDEardresGGTGLGLAIVETAIQQHRGWVKAEDSPlGGLRLVIWLPL 453
Cdd:PRK11073 301 FYPMVSGRE------GGTGLGLSIARNLIDQHSGKIEFTSWP-GHTEFSVYLPI 347
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
242-452 |
4.59e-09 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 58.53 E-value: 4.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 242 LLSDISHELRTPLTRLQLGTALLRR--RSGEskeleRIETEAQRLDSMINDLLVMSRNQQknaLVSETIKANQLWSEVLD 319
Cdd:PRK13557 177 LLQVMSGYLDVIQAALSHPDADRGRmaRSVE-----NIRAAAERAATLTQQLLAFARKQR---LEGRVLNLNGLVSGMGE 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 320 NAAfeaEQMGKSLTV--NFPPGPWPLYGNPNALESALENIVRNA---------LRYSHTKIEVG------FAVDKDG--I 380
Cdd:PRK13557 249 LAE---RTLGDAVTIetDLAPDLWNCRIDPTQAEVALLNVLINArdampeggrVTIRTRNVEIEdedlamYHGLPPGryV 325
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446502575 381 TITVDDDGPGVSPEDREQIFRPFYRTDEardrESGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLP 452
Cdd:PRK13557 326 SIAVTDTGSGMPPEILARVMDPFFTTKE----EGKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFP 393
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
254-453 |
5.48e-09 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 56.55 E-value: 5.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 254 LTRLQLGTALLRRRSGESKELERIETEAQRLDSMINDLLVMSRNqqknaLVSETIKANQLWSEVLDNAAFEAEQMGKSLT 333
Cdd:COG4585 71 AIKLQLEAARRLLDADPEAAREELEEIRELAREALAELRRLVRG-----LRPPALDDLGLAAALEELAERLLRAAGIRVE 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 334 VNFPPGPWPLygnPNALESALENIVR----NALRYSH-TKIEVGFAVDKDGITITVDDDGPGVSPEDReqifrpfyrtde 408
Cdd:COG4585 146 LDVDGDPDRL---PPEVELALYRIVQealtNALKHAGaTRVTVTLEVDDGELTLTVRDDGVGFDPEAA------------ 210
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 446502575 409 ardresGGTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPL 453
Cdd:COG4585 211 ------PGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPL 249
|
|
| CpxA_peri |
pfam16527 |
Two-component sensor protein CpxA, periplasmic domain; CpxA_peri is the periplasmic ... |
81-144 |
1.01e-08 |
|
Two-component sensor protein CpxA, periplasmic domain; CpxA_peri is the periplasmic domain-family of the Gram-negative Gammaproteobacteria two-component signalling system, Cpx. It represents the recognition-site for sensing specific envelope stress signals. The fold that the domain-core of CpxA_peri conforms to is a PAS fold. The domain senses the environmental change and triggers a signal transduction to the cytoplasmic domain. As well as the PAS-core, there is a C-terminal tail that is necessary for ligand-sensing and binding to CpxP, a CpxA-associated and a regulatory protein. This domain recognizes KCl and RbCl (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 435400 [Multi-domain] Cd Length: 134 Bit Score: 53.58 E-value: 1.01e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446502575 81 PGQRLLLVTTEGRVIGAERS---EMQIIRNFIGQADNADHPQKKKYGRVELVGPFSVRDGEDNYQLY 144
Cdd:pfam16527 51 GRPRFFFTDYEGEILTTKRRsdfRLKALRNFVTSIEDPQKPQQKLYGRYMMAGPVPITLADQTLLMY 117
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-446 |
2.15e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 51.69 E-value: 2.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 350 LESALENIVRNALRYSHT----KIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTdeardRESG-GTGLGLAIV 424
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKvenpRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTT-----KPVGkGTGLGLSIS 75
|
90 100
....*....|....*....|..
gi 446502575 425 ETAIQQHRGWVKAEDSPLGGLR 446
Cdd:cd16976 76 YGIVEEHGGRLSVANEEGAGAR 97
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-424 |
1.10e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 49.98 E-value: 1.10e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446502575 353 ALENIVRNALRYSH--TKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYrTDEARDRESGGTGLGLAIV 424
Cdd:cd16948 9 IIGQIVSNALKYSKqgGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGF-TGENGRNFQESTGMGLYLV 81
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
231-433 |
2.81e-07 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 52.77 E-value: 2.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 231 ALGRMMTSqqrllsdISHELRTPLTRL-----QLGTALLRRRSGESKE-LERIETEAQRLDSMINDLLVMSRNQQKNA-L 303
Cdd:COG4192 432 VVGQTMTS-------LAHELNQPLNAMsmylfSAKKALEQENYAQLPTsLDKIEGLIERMDKIIKSLRQFSRKSDTPLqP 504
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 304 VSETIKANQLWSEVldnaAFEAEQMGKSLTVnfpPGPWPLYGNPNALESALENIVRNALRYSHTK--IEVGFAVDKDGIT 381
Cdd:COG4192 505 VDLRQVIEQAWELV----ESRAKPQQITLHI---PDDLMVQGDQVLLEQVLVNLLVNALDAVATQpqISVDLLSNAENLR 577
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 446502575 382 ITVDDDGPGVspEDREQIFRPFYRTDEArdresgGTGLGLAIVETAIQQHRG 433
Cdd:COG4192 578 VAISDNGNGW--PLVDKLFTPFTTTKEV------GLGLGLSICRSIMQQFGG 621
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
349-426 |
3.67e-07 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 48.03 E-value: 3.67e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446502575 349 ALESALENIVRNALRYSHTK-IEVGFAVDKDGITITVDDDGPGVSPEDReqifrpfyRTDEARDRESggtGLGLAIVET 426
Cdd:cd16936 4 AVSEAVTNAVRHAYRHDGPGpVRLELDLDPDRLRVEVTDSGPGFDPLRP--------ADPDAGLREG---GRGLALIRA 71
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
244-423 |
4.54e-07 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 52.25 E-value: 4.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 244 SDISHELRTP------LTRLQLGTALlrrRSGESKELERIETEAQRLDSMINDLLVMSR-NQQKNALVSETIKANQLWSE 316
Cdd:PRK11091 288 STISHELRTPlngivgLSRILLDTEL---TAEQRKYLKTIHVSAITLGNIFNDIIDMDKmERRKLQLDNQPIDFTDFLAD 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 317 VLDNAAFEAEQMGKSLTVNfPPGPWPLY--GNPNALESALENIVRNALRYSHT-KIEVGFAVD-KDGITITVDDDGPGVS 392
Cdd:PRK11091 365 LENLSGLQAEQKGLRFDLE-PLLPLPHKviTDGTRLRQILWNLISNAVKFTQQgGVTVRVRYEeGDMLTFEVEDSGIGIP 443
|
170 180 190
....*....|....*....|....*....|..
gi 446502575 393 PEDREQIFRPFYR-TDEARDRESGGTGLGLAI 423
Cdd:PRK11091 444 EDELDKIFAMYYQvKDSHGGKPATGTGIGLAV 475
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
353-426 |
9.24e-07 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 47.60 E-value: 9.24e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446502575 353 ALENIVRNALRYSH-----TKIEVGFAVDKDGITITVDDDGPGVSPEDREQifrpfyrtdeaRDRESGGTGLGLAIVET 426
Cdd:COG2172 38 AVSEAVTNAVRHAYggdpdGPVEVELELDPDGLEIEVRDEGPGFDPEDLPD-----------PYSTLAEGGRGLFLIRR 105
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
237-419 |
1.94e-06 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 50.32 E-value: 1.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 237 TSQQRLLSDISHELRTPLTRLQLGTALLRRRS---GESKELERIETEAQRLDSMIND--LLVMSRNQQKnALVSETIKAN 311
Cdd:PRK10618 448 QARKAFLQNIGDELKQPLQSLAQLAAQLRQTSdeeQQQPELDQLAEQSDVLVRLVDNiqLLNMLETQDW-KPEQELFSLQ 526
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 312 QLWSEVLDNAAFEAEQMGKSLTVNFPPGPWPLY-GNpnalESALENIVRNALRYSHT-----KIEVGFAVDKDG---ITI 382
Cdd:PRK10618 527 DLIDEVLPEVLPAIKRKGLQLLIHNHLKAEQLRiGD----RDALRKILLLLLNYAITttaygKITLEVDQDESSpdrLTI 602
|
170 180 190
....*....|....*....|....*....|....*..
gi 446502575 383 TVDDDGPGVSPEDREQIFRPFYrTDEARDRESGGTGL 419
Cdd:PRK10618 603 RILDTGAGVSIKELDNLHFPFL-NQTQGDRYGKASGL 638
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
169-453 |
2.51e-06 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 49.63 E-value: 2.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 169 IVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPEleAGPQEFLAAGASFNQMVTALGRMMTSQQRLlsdish 248
Cdd:COG2972 164 LLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVRLEV--SGNDEIGILARSFNEMVERIKELIEEVYEL------ 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 249 ELRtpLTRLQLgtALLR---------------RRSGESKELERIETeaqrldsMINDLLVMSRN--QQKNALVSetikan 311
Cdd:COG2972 236 ELE--KKEAEL--KALQaqinphflfntlnsiRWLAELEDPEEAEE-------MLEALSKLLRYslSKGDELVT------ 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 312 qlWSEVLDNAA--FEAEQM--GKSLTVNF--PPGPW----------PLygnpnalesaLENIVRNALRYS--HTKIEVGF 373
Cdd:COG2972 299 --LEEELELIKsyLEIQKLrfGDRLEVEIeiDEELLdllipklilqPL----------VENAIEHGIEPKegGGTIRISI 366
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 374 AVDKDGITITVDDDGPGVSPEDREQIFRPFyrtdearDRESGGTGLGLAIVETAIQQHRG---WVKAEDSPLGGLRLVIW 450
Cdd:COG2972 367 RKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLKLYYGeeyGLEIESEPGEGTTVTIR 439
|
...
gi 446502575 451 LPL 453
Cdd:COG2972 440 IPL 442
|
|
| HATPase_c_2 |
pfam13581 |
Histidine kinase-like ATPase domain; |
349-426 |
1.42e-05 |
|
Histidine kinase-like ATPase domain;
Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 44.20 E-value: 1.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 349 ALESALENIVRNALRYSHTK-IEVGFAVDKDGITITVDDDGPGVSPEDREqifrpfyRTDEARDRESGGT-GLGLAIVET 426
Cdd:pfam13581 35 AVGEACTNAVEHAYREGPEGpVEVRLTSDGGGLVVTVADSGPPFDPLTLP-------PPDLEEPDEDRKEgGRGLALIRG 107
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
188-232 |
4.25e-05 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 40.51 E-value: 4.25e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 446502575 188 KPARKLKNAADEVAQGNLRQHPELEaGPQEFLAAGASFNQMVTAL 232
Cdd:cd06225 2 RPLRRLTEAARRIAEGDLDVRVPVR-SKDEIGELARAFNQMAERL 45
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-452 |
5.27e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 41.77 E-value: 5.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 357 IVR----NALRYSH-TKIEVGFAVDKDGITITVDDDGPGVSPEDREqifrpfyrtdeardresGGTGLGLAIVETAIQQH 431
Cdd:cd16917 4 IVQealtNALKHAGaSRVRVTLSYTADELTLTVVDDGVGFDGPAPP-----------------GGGGFGLLGMRERAELL 66
|
90 100
....*....|....*....|.
gi 446502575 432 RGWVKAEDSPLGGLRLVIWLP 452
Cdd:cd16917 67 GGTLTIGSRPGGGTRVTARLP 87
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
188-237 |
5.27e-05 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 40.69 E-value: 5.27e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 446502575 188 KPARKLKNAADEVAQGNLRQHPELEaGPQEFLAAGASFNQMVTALGRMMT 237
Cdd:smart00304 5 RPLRRLAEAAQRIADGDLTVRLPVD-GRDEIGELARAFNEMADRLEETIA 53
|
|
| HAMP |
pfam00672 |
HAMP domain; |
188-232 |
9.37e-05 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 39.92 E-value: 9.37e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 446502575 188 KPARKLKNAADEVAQGNLRQHPElEAGPQEFLAAGASFNQMVTAL 232
Cdd:pfam00672 8 RPLRRLAEAARRIASGDLDVRLP-VSGRDEIGELARAFNQMAERL 51
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
348-457 |
1.71e-04 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 44.05 E-value: 1.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 348 NALESALENIVRNalRYSHTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTdeaRDRESGGTGLGLAIVETA 427
Cdd:PRK15053 439 NLLDNAFEASLRS--DEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGVST---RADEPGEHGIGLYLIASY 513
|
90 100 110
....*....|....*....|....*....|
gi 446502575 428 IQQHRGWVKAEDSPLGGLRLVIWLPLYKRS 457
Cdd:PRK15053 514 VTRCGGVITLEDNDPCGTLFSIFIPKVKPN 543
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
257-453 |
5.77e-04 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 42.20 E-value: 5.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 257 LQLGTALLR--RRSGESKELERIETEAQ-RLDSM--INDLLVMSRNqqknalvSETIKANQLWSEVLDNAAFEAEQMGKS 331
Cdd:COG3920 310 LQVVSSLLRlqARRADDPEAREALEESQnRIQALalVHELLYQSED-------WEGVDLRDYLRELLEPLRDSYGGRGIR 382
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 332 LTVNFPPgpwpLYGNPNALES-AL---EnIVRNALRY-----SHTKIEVGFAVDKDGITITVDDDGPGVsPEDREqifrp 402
Cdd:COG3920 383 IELDGPD----VELPADAAVPlGLilnE-LVTNALKHaflsgEGGRIRVSWRREDGRLRLTVSDNGVGL-PEDVD----- 451
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 446502575 403 fyrtdeardrESGGTGLGLAIVETAIQQHRGWVKAEDSPlgGLRLVIWLPL 453
Cdd:COG3920 452 ----------PPARKGLGLRLIRALVRQLGGTLELDRPE--GTRVRITFPL 490
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
188-331 |
9.96e-04 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 41.54 E-value: 9.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446502575 188 KPARKLKNAADEVAQGNLRQHPELEaGPQEFLAAGASFNQMVTALGRMMTSqqrlLSDISHELRTPLTRLQLGTALLRRR 267
Cdd:COG0840 208 RPLRELLEVLERIAEGDLTVRIDVD-SKDEIGQLADAFNRMIENLRELVGQ----VRESAEQVASASEELAASAEELAAG 282
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446502575 268 SGE-SKELERIETEAQRLDSMINDllVMSRNQQKNALVSETIKANQLWSEVLDNAAFEAEQMGKS 331
Cdd:COG0840 283 AEEqAASLEETAAAMEELSATVQE--VAENAQQAAELAEEASELAEEGGEVVEEAVEGIEEIRES 345
|
|
| |
