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Conserved domains on  [gi|446499337|ref|WP_000577191|]
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MULTISPECIES: GntR family transcriptional regulator [Enterobacteriaceae]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
2-228 1.69e-71

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 217.81  E-value: 1.69e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337   2 IFQKIARLLKSEINGYSWHVGDLLPSEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTYIQKKNFVAHIDHMNSFS 81
Cdd:COG2188    6 LYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTSFT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337  82 EIAHKSGKEAGSQIMKFEVQDASPTIATELNLVPGEQVYYIKRLRFIEDNAAQLEETWMSVARFPDLTVSHMQK-SKFSY 160
Cdd:COG2188   86 EELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETgSLYEL 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337 161 IENECGIKIIGTYETFSPTFPTPEIASILRISPRDPILKIQTQAVDSNSIPLDYSLLY--SNIFEFQVKY 228
Cdd:COG2188  166 LEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYyrGDRYRFVVEL 235
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
2-228 1.69e-71

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 217.81  E-value: 1.69e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337   2 IFQKIARLLKSEINGYSWHVGDLLPSEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTYIQKKNFVAHIDHMNSFS 81
Cdd:COG2188    6 LYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTSFT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337  82 EIAHKSGKEAGSQIMKFEVQDASPTIATELNLVPGEQVYYIKRLRFIEDNAAQLEETWMSVARFPDLTVSHMQK-SKFSY 160
Cdd:COG2188   86 EELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETgSLYEL 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337 161 IENECGIKIIGTYETFSPTFPTPEIASILRISPRDPILKIQTQAVDSNSIPLDYSLLY--SNIFEFQVKY 228
Cdd:COG2188  166 LEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYyrGDRYRFVVEL 235
PRK09764 PRK09764
GntR family transcriptional regulator;
3-215 1.22e-43

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 146.90  E-value: 1.22e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337   3 FQKIARLLKSEINGYSWHVGDLLPSEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTYIQKKNFVAHIDHMNSFSE 82
Cdd:PRK09764   7 YRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQLTSFDE 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337  83 IAHKSGKEAGSQIMKFEVQDASPTIATELNLVPGEQVYYIKRLRFIEDNAAQLEETWMSVARFPDLTVSHMQKSKFSYIE 162
Cdd:PRK09764  87 KLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSKYHFIE 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446499337 163 NECGIKIIGTYETFSPTFPTPEIASILRISPRDPILKIQTQAVDSNSIPLDYS 215
Cdd:PRK09764 167 EVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYS 219
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 88-218 5.94e-34

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 118.94  E-value: 5.94e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337    88 GKEAGSQIMKFEVQDASPTIATELNLVPGEQVYYIKRLRFIEDNAAQLEETWMSVARFPDLTVSHMQKSKFSYIENECGI 167
Cdd:smart00866   3 GRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEERLGL 82

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 446499337   168 KIIGTY---ETFSPTFPTPEIASILRISPRDPILKIQTQAVDSNSIPLDYSLLY 218
Cdd:smart00866  83 KIVRSTraeQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSY 136
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 2-216 1.01e-32

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 118.73  E-value: 1.01e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337    2 IFQKIARLLKSEINGYSWHVGDLLPSEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTYIQKKNFVAHIDHMNSFS 81
Cdd:TIGR02325   9 LWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPLSARTRFS 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337   82 EIAHKSGKEAGSQIMKFEVQDASPTIATELNLVPGEQVYYIKRLRFIEDNAAQLEETWMSVARFPDLTVSHMQKSKFSYI 161
Cdd:TIGR02325  89 QNLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPGIGQAYAASGSITDA 168

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 446499337  162 ENECGIKIIGTYET-FSPTFPTPEIASILRISPRDPILKIQTQAVDSNSIPLDYSL 216
Cdd:TIGR02325 169 LREQGVADYRRSSTrISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSV 224
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 88-218 4.14e-32

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 114.23  E-value: 4.14e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337   88 GKEAGSQIMKFEVQDASPTIATELNLVPGEQVYYIKRLRFIEDNAAQLEETWMSVARFPDLTVSHMQK-SKFSYIENECG 166
Cdd:pfam07702   3 GREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEgSLYDYLEERYG 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 446499337  167 IKIIGTYETFSPTFPTPEIASILRISPRDPILKIQTQAVDSNSIPLDYSLLY 218
Cdd:pfam07702  83 LPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSY 134
GntR_LSA1692 NF041547
GntR family transcriptional regulator, LSA1692 subfamily;
2-214 8.88e-29

GntR family transcriptional regulator, LSA1692 subfamily;


Pssm-ID: 469432 [Multi-domain]  Cd Length: 233  Bit Score: 107.99  E-value: 8.88e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337   2 IFQKIARLLKSEINGYSWHVGDLLPSEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTYIQKKNFVAH-IDHMNSF 80
Cdd:NF041547   2 LYEEVADKIEKRIKDGVYGSHQKLPSEYDLAKEFEVSRLTIRKAIDLLIKQQVLVKDRGKGTYVMAQQKIQSgRGGLQGF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337  81 SEIAHKSGKEAGSQIMKFE-VQDASPTIATELNLVPGEQVYYIKRLRFIEDNAAQLEETWMSVARFPDLTVSHMQKSKFS 159
Cdd:NF041547  82 TEAAKAYGKTSHTKVLEFEeLTNYPEEVKEKLELEENEPVWHIERLRFWDDEPMTVEEIYIREKYLPELTEEDFEGSLFE 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446499337 160 YIENEcgIKIIGTYETFSPTFPTPEIASILRISPRDPILKIQTQAVDSNSIPLDY 214
Cdd:NF041547 162 LIEKK--IEIAYSHQEIEAVLVDEELSELLKVKVGSPLLLVHSVTYSVDGYPILY 214
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 2-65 1.94e-20

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 81.34  E-value: 1.94e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446499337   2 IFQKIARLLKSEINGYSWHVGDLLPSEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTYI 65
Cdd:cd07377    2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
2-228 1.69e-71

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 217.81  E-value: 1.69e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337   2 IFQKIARLLKSEINGYSWHVGDLLPSEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTYIQKKNFVAHIDHMNSFS 81
Cdd:COG2188    6 LYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTSFT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337  82 EIAHKSGKEAGSQIMKFEVQDASPTIATELNLVPGEQVYYIKRLRFIEDNAAQLEETWMSVARFPDLTVSHMQK-SKFSY 160
Cdd:COG2188   86 EELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETgSLYEL 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337 161 IENECGIKIIGTYETFSPTFPTPEIASILRISPRDPILKIQTQAVDSNSIPLDYSLLY--SNIFEFQVKY 228
Cdd:COG2188  166 LEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYyrGDRYRFVVEL 235
PRK09764 PRK09764
GntR family transcriptional regulator;
3-215 1.22e-43

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 146.90  E-value: 1.22e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337   3 FQKIARLLKSEINGYSWHVGDLLPSEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTYIQKKNFVAHIDHMNSFSE 82
Cdd:PRK09764   7 YRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQLTSFDE 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337  83 IAHKSGKEAGSQIMKFEVQDASPTIATELNLVPGEQVYYIKRLRFIEDNAAQLEETWMSVARFPDLTVSHMQKSKFSYIE 162
Cdd:PRK09764  87 KLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSKYHFIE 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446499337 163 NECGIKIIGTYETFSPTFPTPEIASILRISPRDPILKIQTQAVDSNSIPLDYS 215
Cdd:PRK09764 167 EVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYS 219
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 88-218 5.94e-34

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 118.94  E-value: 5.94e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337    88 GKEAGSQIMKFEVQDASPTIATELNLVPGEQVYYIKRLRFIEDNAAQLEETWMSVARFPDLTVSHMQKSKFSYIENECGI 167
Cdd:smart00866   3 GRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEERLGL 82

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 446499337   168 KIIGTY---ETFSPTFPTPEIASILRISPRDPILKIQTQAVDSNSIPLDYSLLY 218
Cdd:smart00866  83 KIVRSTraeQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSY 136
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 2-216 1.01e-32

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 118.73  E-value: 1.01e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337    2 IFQKIARLLKSEINGYSWHVGDLLPSEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTYIQKKNFVAHIDHMNSFS 81
Cdd:TIGR02325   9 LWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPLSARTRFS 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337   82 EIAHKSGKEAGSQIMKFEVQDASPTIATELNLVPGEQVYYIKRLRFIEDNAAQLEETWMSVARFPDLTVSHMQKSKFSYI 161
Cdd:TIGR02325  89 QNLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPGIGQAYAASGSITDA 168

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 446499337  162 ENECGIKIIGTYET-FSPTFPTPEIASILRISPRDPILKIQTQAVDSNSIPLDYSL 216
Cdd:TIGR02325 169 LREQGVADYRRSSTrISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSV 224
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 88-218 4.14e-32

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 114.23  E-value: 4.14e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337   88 GKEAGSQIMKFEVQDASPTIATELNLVPGEQVYYIKRLRFIEDNAAQLEETWMSVARFPDLTVSHMQK-SKFSYIENECG 166
Cdd:pfam07702   3 GREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEgSLYDYLEERYG 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 446499337  167 IKIIGTYETFSPTFPTPEIASILRISPRDPILKIQTQAVDSNSIPLDYSLLY 218
Cdd:pfam07702  83 LPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSY 134
GntR_LSA1692 NF041547
GntR family transcriptional regulator, LSA1692 subfamily;
2-214 8.88e-29

GntR family transcriptional regulator, LSA1692 subfamily;


Pssm-ID: 469432 [Multi-domain]  Cd Length: 233  Bit Score: 107.99  E-value: 8.88e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337   2 IFQKIARLLKSEINGYSWHVGDLLPSEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTYIQKKNFVAH-IDHMNSF 80
Cdd:NF041547   2 LYEEVADKIEKRIKDGVYGSHQKLPSEYDLAKEFEVSRLTIRKAIDLLIKQQVLVKDRGKGTYVMAQQKIQSgRGGLQGF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337  81 SEIAHKSGKEAGSQIMKFE-VQDASPTIATELNLVPGEQVYYIKRLRFIEDNAAQLEETWMSVARFPDLTVSHMQKSKFS 159
Cdd:NF041547  82 TEAAKAYGKTSHTKVLEFEeLTNYPEEVKEKLELEENEPVWHIERLRFWDDEPMTVEEIYIREKYLPELTEEDFEGSLFE 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446499337 160 YIENEcgIKIIGTYETFSPTFPTPEIASILRISPRDPILKIQTQAVDSNSIPLDY 214
Cdd:NF041547 162 LIEKK--IEIAYSHQEIEAVLVDEELSELLKVKVGSPLLLVHSVTYSVDGYPILY 214
PRK11402 PRK11402
transcriptional regulator PhoB;
2-218 1.14e-27

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 105.30  E-value: 1.14e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337   2 IFQKIARLLKSEINGYSWHVGDLLPSEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTYIQKKNFVAHIDHMNSFS 81
Cdd:PRK11402  10 LYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVSGFT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337  82 EIAHKSGKEAGSQIMKFEVQDASPtIATELNLVPGEQVYYIKRLRFIEDNAAQLEETWMSVARFPDL-TVSHMQKSKFSY 160
Cdd:PRK11402  90 DFGVSQGKATKEKVIEQERVSAAP-FCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFdEIYVEGSSTYQL 168

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446499337 161 IENECGIKIIGTYETFSPTFPTPEIASILRISPRDPILKIQTQAVDSNSIPLDYSLLY 218
Cdd:PRK11402 169 FQERFDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELF 226
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 3-169 3.34e-26

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 101.29  E-value: 3.34e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337    3 FQKIARLLKSEINGYSWHVGDLLPSEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTY-IQKKNFVAHIDHMNSFS 81
Cdd:TIGR02404   2 YEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIvLNRKQIEFPISGITSFK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337   82 EIAHKSGKEAGSQIMKFEVQDASP-TIATELNLVPGEQVYYIKRLRFIEDNAAQLEETWMSVARFPDLTVSHMQKSKFSY 160
Cdd:TIGR02404  82 ELNETLGLDSKTEVVELDKEDPLPeTLAQLTGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEIAEDSIYQY 161


                  ....*....
gi 446499337  161 IENECGIKI 169
Cdd:TIGR02404 162 LENELGLAI 170
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 2-65 1.94e-20

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 81.34  E-value: 1.94e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446499337   2 IFQKIARLLKSEINGYSWHVGDLLPSEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTYI 65
Cdd:cd07377    2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
2-87 2.06e-19

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 83.44  E-value: 2.06e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337   2 IFQKIARLLKSEI-NGySWHVGDLLPSEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTYIQKKNFVAHIDHMNSF 80
Cdd:COG2186    8 LAEQVAEQLRELIlSG-ELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLDPLALL 86


                 ....*..
gi 446499337  81 SEIAHKS 87
Cdd:COG2186   87 LALDDAS 93
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 4-65 1.43e-18

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 76.50  E-value: 1.43e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446499337    4 QKIARLLKSEINGYSWHVGDLLPSEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTYI 65
Cdd:pfam00392   3 EQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
6-65 1.46e-16

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 71.07  E-value: 1.46e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337     6 IARLLKSEINGYSWHVGDLLPSEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTYI 65
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 3-216 3.35e-14

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 69.42  E-value: 3.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337   3 FQKIARLLKSEINGYsWHVGDLLPSEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTYIQKKNFVAHIDHMNSFSE 82
Cdd:PRK10079  14 YQEIAAKLEQELRQH-YRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPYDYPLNAQARFSQ 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337  83 IAHKSGKEAGSQIMKFEVQDASPTIATELNLVPGEQVYYIKRLRFIEDNAAQLEETWmsvarFPDLTV-SHMQK----SK 157
Cdd:PRK10079  93 NLLDQGSHPTSEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNGVALCLIDHY-----FADLTWwPTLQRfdsgSL 167

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337 158 FSYIENECGIKIIGTYETFSPTFPTPEIASILRISPRDPILKIQT-QAVDSNSIPLDYSL 216
Cdd:PRK10079 168 HDFLREQLGIALRRSQTRISARRAQAKESQLLEIPNMSPLLCVRTlNHRDGESSPAEYSV 227
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
2-65 3.20e-13

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 64.04  E-value: 3.20e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446499337   2 IFQKIARLLKSEINGYSWHVGDLLPSEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTYI 65
Cdd:COG1725   11 IYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFV 74
PRK14999 PRK14999
histidine utilization repressor; Provisional
 3-218 3.70e-13

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 66.49  E-value: 3.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337   3 FQKIARLLKSEINGYSWHVGDLLPSEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTYIQKKNFVAHIDHMNSFS- 81
Cdd:PRK14999  14 YETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQSALFEVRSIAe 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337  82 EIAHKSGKEAgSQIMKFEVQDASPTIATELNLVPGEQVYYIKRLRFIEDNAAQLEETWMSVARFPD-LTVSHMQKSKFSY 160
Cdd:PRK14999  94 EIAARRHQHR-CEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVDyLTQDYRQTTPHAY 172

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446499337 161 IENEC----GIKIIGTYETfsptfpTPEIASILRISPRDPILKIQTQAVDSNSIPLDYSLLY 218
Cdd:PRK14999 173 LSRIAplteGEHIVEAVRA------TAQECAWLTIKEHEPCLLIRRTTWSASRIVSHARLLF 228
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 2-65 9.88e-12

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 63.69  E-value: 9.88e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446499337   2 IFQKIARLLKSEINGYSWHVGDLLPSEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTYI 65
Cdd:COG1167   13 LYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFV 76
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
4-75 2.11e-09

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 55.70  E-value: 2.11e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446499337   4 QKIARLLKSEINGyswhvGDLLP----SEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTyiqkknFVAHID 75
Cdd:COG1802   14 EQVYEALREAILS-----GELPPgerlSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGA------RVAPLS 78
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
22-68 1.95e-08

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 53.10  E-value: 1.95e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 446499337  22 GDLLPSEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTYIQKK 68
Cdd:PRK09464  31 GEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSS 77
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 22-66 4.77e-08

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 52.08  E-value: 4.77e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 446499337  22 GDLLPSEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTYIQ 66
Cdd:PRK10421  23 GMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIR 67
PRK11523 PRK11523
transcriptional regulator ExuR;
2-72 1.07e-07

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 51.00  E-value: 1.07e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446499337   2 IFQKIARLLKSEINGYSWHVGDLLPSEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTYI---QKKNFVA 72
Cdd:PRK11523   9 LYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVvsnQPRHQQA 82
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 21-85 2.39e-07

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 50.15  E-value: 2.39e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446499337  21 VGDLLPSEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTyiqkknFVAHIDHMNSFSEIAH 85
Cdd:PRK09990  27 VGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGS------FVARLNRVQDASPLMH 85
PRK10225 PRK10225
Uxu operon transcriptional regulator;
3-65 3.48e-07

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 49.63  E-value: 3.48e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446499337   3 FQKIARLLKSEINGYSWHVGDLLPSEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTYI 65
Cdd:PRK10225  11 YQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYV 73
PRK10411 PRK10411
L-fucose operon activator;
4-87 1.81e-05

L-fucose operon activator;


Pssm-ID: 236684 [Multi-domain]  Cd Length: 240  Bit Score: 44.41  E-value: 1.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446499337   4 QKIARLLkseingyswHVGDLLPSEAeLAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTYIQKKNfvahIDHMNSF--- 80
Cdd:PRK10411   7 QAIVDLL---------LNHTSLTTEA-LAEQLNVSKETIRRDLNELQTQGKILRNHGRAKYIHRQN----QDSGDPFhir 72


                 ....*....
gi 446499337  81 --SEIAHKS 87
Cdd:PRK10411  73 lkSHYAHKA 81
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 22-60 6.15e-05

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 42.70  E-value: 6.15e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 446499337  22 GDLLPSEAELAVRYNVSRNTLRKALSLLEGEGIIHRKHG 60
Cdd:PRK03837  34 GDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHG 72
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 29-60 6.23e-04

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 39.73  E-value: 6.23e-04
                         10        20        30
                 ....*....|....*....|....*....|..
gi 446499337  29 AELAVRYNVSRNTLRKALSLLEGEGIIHRKHG 60
Cdd:COG1349   23 EELAERLGVSEETIRRDLAELEEQGLLRRVHG 54
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
30-68 1.95e-03

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 35.31  E-value: 1.95e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 446499337   30 ELAVRYNVSRNTLRKALSLLEGEGIIHRKHGSGTYIQKK 68
Cdd:pfam08220  19 ELAELLGVSEMTIRRDLNELEEQGLLTRTHGGAVSNSST 57
HTH_36 pfam13730
Helix-turn-helix domain;
7-55 2.14e-03

Helix-turn-helix domain;


Pssm-ID: 463970 [Multi-domain]  Cd Length: 55  Bit Score: 35.16  E-value: 2.14e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 446499337    7 ARLLKSEINGYSWHVGDLLPSEAELAVRYNVSRNTLRKALSLLEGEGII 55
Cdd:pfam13730   7 AKLLLLILASYANKDGGCFPSVETLAKRLGLSRRTIQRAIKELEELGYL 55
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
30-60 2.44e-03

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 35.28  E-value: 2.44e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 446499337    30 ELAVRYNVSRNTLRKALSLLEGEGIIHRKHG 60
Cdd:smart00420  19 ELAELLGVSEMTIRRDLNKLEEQGLLTRVHG 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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