NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446496167|ref|WP_000574021|]
View 

MULTISPECIES: Cu(+)/Ag(+) efflux RND transporter permease subunit SilA [Enterobacterales]

Protein Classification

efflux RND transporter permease subunit( domain architecture ID 1004191)

efflux RND transporter permease subunit such as a CusA/CzcA family heavy metal efflux RND transporter, similar to Escherichia coli cation efflux system protein CusA, which mediates resistance to copper and silver

Gene Ontology:  GO:0008324|GO:0005886
TCDB:  2.A.6

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ACR_tran super family cl47191
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
 1-1048 0e+00

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


The actual alignment was detected with superfamily member TIGR00914:

Pssm-ID: 481531 [Multi-domain]  Cd Length: 1051  Bit Score: 1675.30  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167     1 MIEWIIRRSVANRFLVMMGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAK 80
Cdd:TIGR00914    1 MIERIISFSVAQRWLVLLATLVMAILGIWSYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167    81 TVRGFSQFGDSYVYVIFEDGTDLYWARSRVLEYLNQVQGKLPAGVSSEIGPDATGVGWIFEYALVDRNG-------KHDL 153
Cdd:TIGR00914   81 TTRSLSRYGLSQVTVIFKDGTDLYFARQLVNERLQQARDNLPEGVSPEMGPISTGLGEIFLYTVEAEEGarkkdggAYTL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   154 SELRSLQDWFLKFELKTIPNVAEVASVGGVVKQYQIQVNPVKLSQYGISLPEVKQALESSNQEAGGSSVEMAEAEYMVRA 233
Cdd:TIGR00914  161 TDLRTIQDWIIRPQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVRA 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   234 SGYLQSIDDFNNIVLKTGEnGVPVYLRDVARVQTGPEMRRGIAELNGQgEVAGGVVILRSGKNARDVITAVRDKLETLKA 313
Cdd:TIGR00914  241 PGQVQSMDDIRNIVIATGE-GVPIRIRDVARVQIGKELRTGAATENGK-EVVLGTVFMLIGENSRTVAQAVGDKLETINK 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   314 SLPEGVEIVTTYDRSQLIDRAIDNLSSKLLEEFIVVAIVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSL 393
Cdd:TIGR00914  319 TLPEGVEIVTTYDRSQLVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPLSLLITFIGMVFQGISANLMSL 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   394 GgiAIAVGAMVDAAIVMIENAHKRLEEWDHQHpGEQIDNATRWKVITDASVEVGPALFISLLIITLSFIPIFTLEGQEGR 473
Cdd:TIGR00914  399 G--ALDFGLIVDGAVVIVENAHRRLAEAQHHH-GRQLTLKERLHEVFAASREVRRPLIFGQLIITLVFLPIFTLTGVEGK 475

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   474 LFGPLAFTKTYSMAGAAALAIIVIPILMGFWIRGKIPaETSNPLNRVLIKAYHPLLLRVLHWPKTTLLVAALSIFTVIWP 553
Cdd:TIGR00914  476 MFHPMAFTVVLALAGAMILSLTFVPAAVALFIRGKVA-EKENRLMRVLKRRYEPLLERVLAWPAVVLGAAAVSIVLVVWI 554

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   554 LSQVGGEFLPKINEGDLLYMPSTLPGVSPAEAAALLQTTDKLIKSVPEVASVFGKTGKAETATDSAPLEMVETTIQLKPE 633
Cdd:TIGR00914  555 ASRVGGEFIPSLNEGDLAYQALRIPGTSLAQSVAMQQTLEKLIKSFPEVARVFAKTGTAEIATDPMPPNASDTYIILKPE 634

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   634 DQWRPG--MTIDKIIDELDRTVRLPGLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTVLSDIDATAQSIEAVAKTVPGVV 711
Cdd:TIGR00914  635 SQWPEGkkTKEDLIEEIQEATVRIPGNNYEFTQPIQMRFNELISGVRSDVAVKVFGDDLDDLDATAEKISAVLKGVPGAA 714

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   712 SVLAERLEGGRYIDIDINREKASRYGMTVGDVQLFVSSAIGGAMVGETVEGVARYPINIRYPQDYRNSPQALKQMPILTP 791
Cdd:TIGR00914  715 DVKVEQTTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETFEGDRRFDIVIRLPESLRESPQALRQLPIPLP 794

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   792 -----MKQQITLGDVADINVVSGPTMLKTENARPASWIYVDARGRDMVSVVNDIKTAISEKVKLRPGTSVAFSGQFELLE 866
Cdd:TIGR00914  795 lsedaRKQFIPLSDVADLRVSPGPNQISRENGKRRVVVSANVRGRDLGSFVDDAKKAIAEQVKLPPGYWITWGGQFEQLQ 874

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   867 HANKKLKLMVPMTVMIIFILLYLAFRRVDEALLILMSLPFALVGGIWFLYWQGFHMSVATGTGFIALAGVAAEFGVVMLM 946
Cdd:TIGR00914  875 SATKRLQIVVPVTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALWLRGIPLSISAAVGFIALSGVAVLNGLVMIS 954

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   947 YLRHAIEAHPElsrketftpegLDEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPLL 1026
Cdd:TIGR00914  955 FIRKLLEEGPS-----------LDEAVYEGALTRVRPVLMTALVASLGFVPMAIATGTGAEVQRPLATVVIGGIITATLL 1023

                         1050      1060
                   ....*....|....*....|..
gi 446496167  1027 SLFIIPAAYKLIWLRRHKKSVS 1048
Cdd:TIGR00914 1024 TLFVLPALYRLVHRRRHKGRKE 1045
 
Name Accession Description Interval E-value
2A0601 TIGR00914
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ...
 1-1048 0e+00

heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 129992 [Multi-domain]  Cd Length: 1051  Bit Score: 1675.30  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167     1 MIEWIIRRSVANRFLVMMGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAK 80
Cdd:TIGR00914    1 MIERIISFSVAQRWLVLLATLVMAILGIWSYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167    81 TVRGFSQFGDSYVYVIFEDGTDLYWARSRVLEYLNQVQGKLPAGVSSEIGPDATGVGWIFEYALVDRNG-------KHDL 153
Cdd:TIGR00914   81 TTRSLSRYGLSQVTVIFKDGTDLYFARQLVNERLQQARDNLPEGVSPEMGPISTGLGEIFLYTVEAEEGarkkdggAYTL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   154 SELRSLQDWFLKFELKTIPNVAEVASVGGVVKQYQIQVNPVKLSQYGISLPEVKQALESSNQEAGGSSVEMAEAEYMVRA 233
Cdd:TIGR00914  161 TDLRTIQDWIIRPQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVRA 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   234 SGYLQSIDDFNNIVLKTGEnGVPVYLRDVARVQTGPEMRRGIAELNGQgEVAGGVVILRSGKNARDVITAVRDKLETLKA 313
Cdd:TIGR00914  241 PGQVQSMDDIRNIVIATGE-GVPIRIRDVARVQIGKELRTGAATENGK-EVVLGTVFMLIGENSRTVAQAVGDKLETINK 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   314 SLPEGVEIVTTYDRSQLIDRAIDNLSSKLLEEFIVVAIVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSL 393
Cdd:TIGR00914  319 TLPEGVEIVTTYDRSQLVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPLSLLITFIGMVFQGISANLMSL 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   394 GgiAIAVGAMVDAAIVMIENAHKRLEEWDHQHpGEQIDNATRWKVITDASVEVGPALFISLLIITLSFIPIFTLEGQEGR 473
Cdd:TIGR00914  399 G--ALDFGLIVDGAVVIVENAHRRLAEAQHHH-GRQLTLKERLHEVFAASREVRRPLIFGQLIITLVFLPIFTLTGVEGK 475

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   474 LFGPLAFTKTYSMAGAAALAIIVIPILMGFWIRGKIPaETSNPLNRVLIKAYHPLLLRVLHWPKTTLLVAALSIFTVIWP 553
Cdd:TIGR00914  476 MFHPMAFTVVLALAGAMILSLTFVPAAVALFIRGKVA-EKENRLMRVLKRRYEPLLERVLAWPAVVLGAAAVSIVLVVWI 554

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   554 LSQVGGEFLPKINEGDLLYMPSTLPGVSPAEAAALLQTTDKLIKSVPEVASVFGKTGKAETATDSAPLEMVETTIQLKPE 633
Cdd:TIGR00914  555 ASRVGGEFIPSLNEGDLAYQALRIPGTSLAQSVAMQQTLEKLIKSFPEVARVFAKTGTAEIATDPMPPNASDTYIILKPE 634

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   634 DQWRPG--MTIDKIIDELDRTVRLPGLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTVLSDIDATAQSIEAVAKTVPGVV 711
Cdd:TIGR00914  635 SQWPEGkkTKEDLIEEIQEATVRIPGNNYEFTQPIQMRFNELISGVRSDVAVKVFGDDLDDLDATAEKISAVLKGVPGAA 714

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   712 SVLAERLEGGRYIDIDINREKASRYGMTVGDVQLFVSSAIGGAMVGETVEGVARYPINIRYPQDYRNSPQALKQMPILTP 791
Cdd:TIGR00914  715 DVKVEQTTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETFEGDRRFDIVIRLPESLRESPQALRQLPIPLP 794

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   792 -----MKQQITLGDVADINVVSGPTMLKTENARPASWIYVDARGRDMVSVVNDIKTAISEKVKLRPGTSVAFSGQFELLE 866
Cdd:TIGR00914  795 lsedaRKQFIPLSDVADLRVSPGPNQISRENGKRRVVVSANVRGRDLGSFVDDAKKAIAEQVKLPPGYWITWGGQFEQLQ 874

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   867 HANKKLKLMVPMTVMIIFILLYLAFRRVDEALLILMSLPFALVGGIWFLYWQGFHMSVATGTGFIALAGVAAEFGVVMLM 946
Cdd:TIGR00914  875 SATKRLQIVVPVTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALWLRGIPLSISAAVGFIALSGVAVLNGLVMIS 954

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   947 YLRHAIEAHPElsrketftpegLDEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPLL 1026
Cdd:TIGR00914  955 FIRKLLEEGPS-----------LDEAVYEGALTRVRPVLMTALVASLGFVPMAIATGTGAEVQRPLATVVIGGIITATLL 1023

                         1050      1060
                   ....*....|....*....|..
gi 446496167  1027 SLFIIPAAYKLIWLRRHKKSVS 1048
Cdd:TIGR00914 1024 TLFVLPALYRLVHRRRHKGRKE 1045
CusA COG3696
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
1-1045 0e+00

Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];


Pssm-ID: 442911 [Multi-domain]  Cd Length: 1031  Bit Score: 1482.97  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167    1 MIEWIIRRSVANRFLVMMGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAK 80
Cdd:COG3696     1 MLNRIIRFSLRNRLLVLLLTLLLAAAGIYSLRRLPIDAFPDITNVQVQVITEAPGLSPEEVEQQVTYPIETALNGLPGVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   81 TVRGFSQFGDSYVYVIFEDGTDLYWARSRVLEYLNQVQGKLPAGVSSEIGPDATGVGWIFEYALVDRNGKHDLSELRSLQ 160
Cdd:COG3696    81 EVRSISRFGLSVVTVIFEDGTDIYWARQLVLERLQQVREQLPAGVTPELGPISTGLGEIYQYTLESDPGKYSLMELRTLQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  161 DWFLKFELKTIPNVAEVASVGGVVKQYQIQVNPVKLSQYGISLPEVKQALESSNQEAGGSSVEMAEAEYMVRASGYLQSI 240
Cdd:COG3696   161 DWVIRPQLRSVPGVAEVNSFGGFVKQYQVLVDPAKLRAYGLTLDDVIEALERNNANVGGGYIERGGQEYLVRGIGLIRSL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  241 DDFNNIVLKTgENGVPVYLRDVARVQTGPEMRRGIAELNGQGEVAGGVVILRSGKNARDVITAVRDKLETLKASLPEGVE 320
Cdd:COG3696   241 EDIENIVVKT-RNGTPVLLRDVAEVRIGPAPRRGAATLNGEGEVVGGIVLMLKGENALEVIEAVKAKLAELKPSLPEGVK 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  321 IVTTYDRSQLIDRAIDNLSSKLLEEFIVVAIVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIAIAV 400
Cdd:COG3696   320 IVPFYDRSDLIDRAIHTVTKNLLEGALLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLGGLAIDF 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  401 GAMVDAAIVMIENAHKRLEEWDHQHPGEQidnatRWKVITDASVEVGPALFISLLIITLSFIPIFTLEGQEGRLFGPLAF 480
Cdd:COG3696   400 GIIVDGAVVMVENILRRLEENRAAGTPRE-----RLEVVLEAAREVRRPIFFATLIIILVFLPIFTLEGVEGKLFRPMAL 474

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  481 TKTYSMAGAAALAIIVIPILMGFWIRGKIPaETSNPLNRVLIKAYHPLLLRVLHWPKTTLLVAALSIFTVIWPLSQVGGE 560
Cdd:COG3696   475 TVIFALLGALLLSLTLVPVLASLLLRGKVP-EKENPLVRWLKRLYRPLLRWALRHPKLVLAVALVLLVLALALFPRLGSE 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  561 FLPKINEGDLLYMPSTLPGVSPAEAAALLQTTDKLIKSVPEVASVFGKTGKAETATDSAPLEMVETTIQLKPEDQWRPGM 640
Cdd:COG3696   554 FLPELDEGDLLVMATLPPGISLEESVELGQQVERILKSFPEVESVVSRTGRAEDATDPMGVNMSETFVILKPRSEWRSGR 633

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  641 TIDKIIDELDRTV-RLPGLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTVLSDIDATAQSIEAVAKTVPGVVSVLAERLE 719
Cdd:COG3696   634 TKEELIAEMREALeQIPGVNFNFSQPIQMRVDELLSGVRADVAVKIFGDDLDVLRRLAEQIEAVLKTVPGAADVQVERVT 713

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  720 GGRYIDIDINREKASRYGMTVGDVQLFVSSAIGGAMVGETVEGVARYPINIRYPQDYRNSPQALKQMPILTPMKQQITLG 799
Cdd:COG3696   714 GLPQLDIRIDRDAAARYGLNVADVQDVVETAIGGKAVGQVYEGERRFDIVVRLPEELRDDPEAIRNLPIPTPSGAQVPLS 793

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  800 DVADINVVSGPTMLKTENARPASWIYVDARGRDMVSVVNDIKTAISEKVKLRPGTSVAFSGQFELLEHANKKLKLMVPMT 879
Cdd:COG3696   794 QVADIEVVEGPNQISRENGRRRIVVQANVRGRDLGSFVAEAQAKVAEQVKLPPGYYIEWGGQFENLQRATARLAIVVPLA 873

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  880 VMIIFILLYLAFRRVDEALLILMSLPFALVGGIWFLYWQGFHMSVATGTGFIALAGVAAEFGVVMLMYLRHAIEAHpels 959
Cdd:COG3696   874 LLLIFLLLYLAFGSVRDALLILLNVPFALIGGVLALWLRGMPLSVSAGVGFIALFGVAVLNGVVLVSYINQLRAEG---- 949

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  960 rketftpEGLDEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPLLSLFIIPAAYKLIW 1039
Cdd:COG3696   950 -------LDLREAIIEGALERLRPVLMTALVAALGLLPMALSTGPGSEVQRPLATVVIGGLITSTLLTLLVLPALYLLFG 1022


                  ....*.
gi 446496167 1040 LRRHKK 1045
Cdd:COG3696  1023 RRRLRR 1028
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
 1-1038 0e+00

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 719.46  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167     1 MIEWIIRRSVAnrflVMMGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAK 80
Cdd:pfam00873    1 MSKFFIRRPIF----TLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167    81 TVRGFSQFGDSYVYVIFEDGTDLYWARSRVLEYLNQVQGKLPAGVSS-EIGPDATGVGWIFEYALVDRNGKHDLSELRSL 159
Cdd:pfam00873   77 YMSSQSSYGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGVQRpGISVIKTSLGPIMVLAVTSPDGSYTQTDLRDY 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   160 QDWFLKFELKTIPNVAEVASVGGVVKQYQIQVNPVKLSQYGISLPEVKQALESSNQEAGGSSVEMAEAEYMVRASGYLQS 239
Cdd:pfam00873  157 ADTNIKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQS 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   240 IDDFNNIVLKtGENGVPVYLRDVARVQTGPEMRRGIAELNGQgEVAGGVVILRSGKNARDVITAVRDKLETLKASLPEGV 319
Cdd:pfam00873  237 AEDFEKIIVK-NQDGSPVRLRDVATVELGSELYRGFATFNGK-PAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQGV 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   320 EIVTTYDRSQLIDRAIDNLSSKLLEEFIVVAIVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIAIA 399
Cdd:pfam00873  315 EIVVVYDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLA 394

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   400 VGAMVDAAIVMIENAHKRLEEwDHQHPGEQIDNATRwkvitdasvEVGPALFISLLIITLSFIPIFTLEGQEGRLFGPLA 479
Cdd:pfam00873  395 IGLVVDDAIVVVENIERVLEE-NGLKPLEAAYKSMG---------EIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFA 464

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   480 FTKTYSMAGAAALAIIVIPILMGFWIRGKIPAE------TSNPLNRVLIKAYHPLLLRVLHWPKTTLLVAALSIFTVIWP 553
Cdd:pfam00873  465 ITIVLAILLSVLVALTLTPALCATLLKPRREPKhggffrWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWL 544

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   554 LSQVGGEFLPKINEGDLLYMPSTLPGVSPAEAAALLQTTDKLIKSVPEVASVFGKTGKAEtATDSAPLEMVETTIQLKPE 633
Cdd:pfam00873  545 FVRIPTEFLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFAF-SGDNNGPNSGDAFISLKPW 623

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   634 DQWR-PGMTIDKIIDELDRTVR-LPGLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTVLSDIDATAQSIEAVAKTVPGVV 711
Cdd:pfam00873  624 KERPgPEKSVQALIERLRKALKqIPGANVFLFQPIQLRGLGTISGFRSDLQVKIFGDDLDALDEARNQILAALAQLPGLS 703

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   712 SVLAERLEGGRYIDIDINREKASRYGMTVGDVQLFVSSAIGGAMVGETVEGVARYPINIRYPQDYRNSPQALKQMPILTP 791
Cdd:pfam00873  704 DVRSDGQEDQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYVRNP 783

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   792 MKQQITLGDVADINVVSGPTMLKTENARPASWIYVDARGRDMVSVVNDIKTAISEKVKLRPGTSVAFSGQFELLEHANKK 871
Cdd:pfam00873  784 YGKMIPLSAFAKIEWGYGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVKLPPGYGYTWTGQFEQEQLAGNS 863

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   872 LKLMVPMTVMIIFILLYLAFRRVDEALLILMSLPFALVGGIWFLYWQGFHMSVATGTGFIALAGVAAEFGVVMlmylrha 951
Cdd:pfam00873  864 LPILIALALLVVFLVLAALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILM------- 936

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   952 IEAHPELSRKETFTPEgldEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPLLSLFII 1031
Cdd:pfam00873  937 VEFANELREQEGKSLE---EAILEACRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVV 1013


                   ....*..
gi 446496167  1032 PAAYKLI 1038
Cdd:pfam00873 1014 PVFYVLF 1020
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
4-1038 2.04e-116

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 383.21  E-value: 2.04e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167    4 WIIRRSVANRFLVMMGALFlsiwGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAKTVR 83
Cdd:NF033617    3 VFIKRPVATLLLSLLILLL----GLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   84 GFSQFGDSYVYVIFEDGTDLYWARSRVLEYLNQVQGKLPAG-----VSSEIGPDATGVGWI-FEYALVDRNGKHDLSELR 157
Cdd:NF033617   79 SQSSLGYSTITLQFRLGTDLDVALSEVQAAINAAQSLLPSEapdppVYRKANSADTPIMYIgLTSEEMPRGQLTDYAERV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  158 slqdwfLKFELKTIPNVAEVASVGGVVKQYQIQVNPVKLSQYGISLPEVKQALESSNQEAGGSSVEMAEAEYMVRASGYL 237
Cdd:NF033617  159 ------LAPKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQL 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  238 QSIDDFNNIVLKTGENGVPVYLRDVARVQTGPEMRRGIAELNGQGEVAGGVVILrSGKNARDVITAVRDKLETLKASLPE 317
Cdd:NF033617  233 KTAEDYEDLVIKYADNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQ-PGANPIEVADEIRALLPELQETLPK 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  318 GVEIVTTYDRSQLIDRAIDNLSSKLLEEFIVVAIVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIA 397
Cdd:NF033617  312 NIKVNVLYDRTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALV 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  398 IAVGAMVDAAIVMIENAHKRLEEWDhqHPGEQIDNATRwkvitdasvEVGpalfISLLIITLS----FIPIFTLEGQEGR 473
Cdd:NF033617  392 LAIGLVVDDAIVVVENIHRHIEEGE--SPLEAALKGAR---------EIG----FTVIAMTLTlvavYLPILFMGGLTGR 456

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  474 LFGPLAFTktysMAGAAALAIIVIPIL---MGFWIRGKIPAEtsNPLNRV-------LIKAYHPLLLRVLHWPKTTLLVA 543
Cdd:NF033617  457 LFREFAVT----LAGAVIISGIVALTLtpmMCSRLLKANEKP--GRFARAvdrffdgLTARYGRGLKWVLKHRPLTLVVA 530

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  544 ALSIFTVIWPLSQVGGEFLPKINEGDLLympSTLPGVSPAEAAALLQTTDKL---IKSVPEVASVFGKTGKAETATDSAP 620
Cdd:NF033617  531 LATLALLPLLYVFIPKELAPSEDRGVIF---GMIQAPQSISLDYMSAKMRDVekiLSSDPEVQSLTSFNGVGGNPGDNTG 607

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  621 LEMvettIQLKPEDQWRpgMTIDKIIDELDRTV-RLPGLA-NLW-VPPIRnridmLSTGIKSPIGIKVSGTvlSDIDA-- 695
Cdd:NF033617  608 FGI----INLKPWDERD--VSAQEIIDRLRPKLaKVPGMDlFLFpLQDLP-----GGAGSSLPQYQVTLTP--SDYDSlf 674

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  696 -TAQSIEAVAKTVPGVVSVLAERLEGGRYIDIDINREKASRYGMTVGDVQLFVSSAIGGAMVGETVEGVARYPINIRYPQ 774
Cdd:NF033617  675 tWAEKLKEKLRKSPQFADVDSDLQDKGPELNVDIDRDKAARLGISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDR 754

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  775 DYRNSPQALKQMPILTPMKQQITLGDVADINVVSGPTMLKTENARPASWIYVD-ARGRDMVSVVNDIKTAISEKVKLrpG 853
Cdd:NF033617  755 RYRLNPEALNQIYVRSNDGKLVPLSTLAKIEERAAPLSLNHFNQFNSATLSFNlAPGVSLGEAIEALDQAAKELLPS--G 832

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  854 TSVAFSGQFELLEHANKKLKLMVPMTVMIIFILLYLAFRRVDEALLILMSLPFALVGGIWFLYWQGFHMSVATGTGFIAL 933
Cdd:NF033617  833 ISGSFQGAARAFQEEGSSLLFLFLLALAAIYLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGLITL 912

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  934 AGVAAEFGVVMlmylrhaIEAHPELSRKETFTPEgldEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIA 1013
Cdd:NF033617  913 IGLVKKNGILM-------VEFANELQRHQGLSRR---EAIYQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLG 982

                        1050      1060
                  ....*....|....*....|....*
gi 446496167 1014 APMIGGMITAPLLSLFIIPAAYKLI 1038
Cdd:NF033617  983 IVIVGGLGVGTLFTLFVLPVVYLLL 1007
PRK15127 PRK15127
multidrug efflux RND transporter permease subunit AcrB;
20-1046 1.00e-61

multidrug efflux RND transporter permease subunit AcrB;


Pssm-ID: 185081 [Multi-domain]  Cd Length: 1049  Bit Score: 229.02  E-value: 1.00e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   20 ALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAKTVRGFS-QFGDSYVYVIFE 98
Cdd:PRK15127   16 AIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSdSTGTVQITLTFE 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   99 DGTDLYWARSRVLEYLNQVQGKLPAGVSSE-IGPDATGVGWIFEYALVDRNGKHDLSELRSLQDWFLKFELKTIPNVAEV 177
Cdd:PRK15127   96 SGTDADIAQVQVQNKLQLAMPLLPQEVQQQgVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDPISRTSGVGDV 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  178 ASVGGvvkQY--QIQVNPVKLSQYGISLPEVKQALESSN------QEAGGSSVEMAEAEYMVRASGYLQSIDDFNNIVLK 249
Cdd:PRK15127  176 QLFGS---QYamRIWMNPNELNKFQLTPVDVINAIKAQNaqvaagQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKILLK 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  250 TGENGVPVYLRDVARVQTGPEMRRGIAELNGQgEVAGGVVILRSGKNARDVITAVRDKLETLKASLPEGVEIVTTYDRSQ 329
Cdd:PRK15127  253 VNQDGSRVRLRDVAKIELGGENYDIIAEFNGQ-PASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTTP 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  330 LIDRAIDNLSSKLLEEFIVVAIVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIAIAVGAMVDAAIV 409
Cdd:PRK15127  332 FVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIV 411

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  410 MIENAHKRLEEwdhqhPGEQIDNATRWKVITDASVEVGPALFISLLiitlsFIPIFTLEGQEGRLFGPLAFTKTYSMAGA 489
Cdd:PRK15127  412 VVENVERVMAE-----EGLPPKEATRKSMGQIQGALVGIAMVLSAV-----FVPMAFFGGSTGAIYRQFSITIVSAMALS 481

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  490 AALAIIVIPILMGFWIR-------GKIPAETSNPLNRVLIKAYHPLLLRVLHWPKTT---LLVAALSIFTVIWPLSQVGG 559
Cdd:PRK15127  482 VLVALILTPALCATMLKpiakgdhGEGKKGFFGWFNRMFEKSTHHYTDSVGNILRSTgryLVLYLIIVVGMAYLFVRLPS 561

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  560 EFLPKINEGDLLYMPSTLPGVSPAEAAALL-QTTDK-LIKSVPEVASV-----FGKTGKAETATDSaplemvetTIQLKP 632
Cdd:PRK15127  562 SFLPDEDQGVFLTMVQLPAGATQERTQKVLnEVTDYyLTKEKNNVESVfavngFGFAGRGQNTGIA--------FVSLKD 633

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  633 EDQwRPG-------------MTIDKIIDELDRTVRLPGLANLWVppirnridmlSTGIKSPIgIKVSGTVLSDI-DATAQ 698
Cdd:PRK15127  634 WAD-RPGeenkveaitmratRAFSQIKDAMVFAFNLPAIVELGT----------ATGFDFEL-IDQAGLGHEKLtQARNQ 701

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  699 SIEAVAKTVPGVVSVLAERLEGGRYIDIDINREKASRYGMTVGDVQLFVSSAIGGAMVGETVEGVARYPINIRYPQDYRN 778
Cdd:PRK15127  702 LLGEAAKHPDMLVGVRPNGLEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRM 781

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  779 SPQALKQMPILTPMKQQITLGDVADINVVSGPTMLKTENARPASWIYVDA-RGRDMVSVVNDIKTAISekvKLRPGTSVA 857
Cdd:PRK15127  782 LPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAaPGKSTGEAMELMEELAS---KLPTGVGYD 858

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  858 FSGQFELLEHANKKLKLMVPMTVMIIFILLYLAFRRVDEALLILMSLPFALVGGIWFLYWQGFHMSVATGTGFIALAGVA 937
Cdd:PRK15127  859 WTGMSYQERLSGNQAPALYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLS 938

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  938 AEFGVVMlmylrhaIEAHPELSRKETftpEGLDEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMI 1017
Cdd:PRK15127  939 AKNAILI-------VEFAKDLMDKEG---KGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVM 1008

                        1050      1060
                  ....*....|....*....|....*....
gi 446496167 1018 GGMITAPLLSLFIIPAAYKLIWLRRHKKS 1046
Cdd:PRK15127 1009 GGMVTATVLAIFFVPVFFVVVRRRFSRKN 1037
 
Name Accession Description Interval E-value
2A0601 TIGR00914
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ...
 1-1048 0e+00

heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 129992 [Multi-domain]  Cd Length: 1051  Bit Score: 1675.30  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167     1 MIEWIIRRSVANRFLVMMGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAK 80
Cdd:TIGR00914    1 MIERIISFSVAQRWLVLLATLVMAILGIWSYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167    81 TVRGFSQFGDSYVYVIFEDGTDLYWARSRVLEYLNQVQGKLPAGVSSEIGPDATGVGWIFEYALVDRNG-------KHDL 153
Cdd:TIGR00914   81 TTRSLSRYGLSQVTVIFKDGTDLYFARQLVNERLQQARDNLPEGVSPEMGPISTGLGEIFLYTVEAEEGarkkdggAYTL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   154 SELRSLQDWFLKFELKTIPNVAEVASVGGVVKQYQIQVNPVKLSQYGISLPEVKQALESSNQEAGGSSVEMAEAEYMVRA 233
Cdd:TIGR00914  161 TDLRTIQDWIIRPQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVRA 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   234 SGYLQSIDDFNNIVLKTGEnGVPVYLRDVARVQTGPEMRRGIAELNGQgEVAGGVVILRSGKNARDVITAVRDKLETLKA 313
Cdd:TIGR00914  241 PGQVQSMDDIRNIVIATGE-GVPIRIRDVARVQIGKELRTGAATENGK-EVVLGTVFMLIGENSRTVAQAVGDKLETINK 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   314 SLPEGVEIVTTYDRSQLIDRAIDNLSSKLLEEFIVVAIVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSL 393
Cdd:TIGR00914  319 TLPEGVEIVTTYDRSQLVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPLSLLITFIGMVFQGISANLMSL 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   394 GgiAIAVGAMVDAAIVMIENAHKRLEEWDHQHpGEQIDNATRWKVITDASVEVGPALFISLLIITLSFIPIFTLEGQEGR 473
Cdd:TIGR00914  399 G--ALDFGLIVDGAVVIVENAHRRLAEAQHHH-GRQLTLKERLHEVFAASREVRRPLIFGQLIITLVFLPIFTLTGVEGK 475

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   474 LFGPLAFTKTYSMAGAAALAIIVIPILMGFWIRGKIPaETSNPLNRVLIKAYHPLLLRVLHWPKTTLLVAALSIFTVIWP 553
Cdd:TIGR00914  476 MFHPMAFTVVLALAGAMILSLTFVPAAVALFIRGKVA-EKENRLMRVLKRRYEPLLERVLAWPAVVLGAAAVSIVLVVWI 554

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   554 LSQVGGEFLPKINEGDLLYMPSTLPGVSPAEAAALLQTTDKLIKSVPEVASVFGKTGKAETATDSAPLEMVETTIQLKPE 633
Cdd:TIGR00914  555 ASRVGGEFIPSLNEGDLAYQALRIPGTSLAQSVAMQQTLEKLIKSFPEVARVFAKTGTAEIATDPMPPNASDTYIILKPE 634

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   634 DQWRPG--MTIDKIIDELDRTVRLPGLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTVLSDIDATAQSIEAVAKTVPGVV 711
Cdd:TIGR00914  635 SQWPEGkkTKEDLIEEIQEATVRIPGNNYEFTQPIQMRFNELISGVRSDVAVKVFGDDLDDLDATAEKISAVLKGVPGAA 714

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   712 SVLAERLEGGRYIDIDINREKASRYGMTVGDVQLFVSSAIGGAMVGETVEGVARYPINIRYPQDYRNSPQALKQMPILTP 791
Cdd:TIGR00914  715 DVKVEQTTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETFEGDRRFDIVIRLPESLRESPQALRQLPIPLP 794

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   792 -----MKQQITLGDVADINVVSGPTMLKTENARPASWIYVDARGRDMVSVVNDIKTAISEKVKLRPGTSVAFSGQFELLE 866
Cdd:TIGR00914  795 lsedaRKQFIPLSDVADLRVSPGPNQISRENGKRRVVVSANVRGRDLGSFVDDAKKAIAEQVKLPPGYWITWGGQFEQLQ 874

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   867 HANKKLKLMVPMTVMIIFILLYLAFRRVDEALLILMSLPFALVGGIWFLYWQGFHMSVATGTGFIALAGVAAEFGVVMLM 946
Cdd:TIGR00914  875 SATKRLQIVVPVTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALWLRGIPLSISAAVGFIALSGVAVLNGLVMIS 954

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   947 YLRHAIEAHPElsrketftpegLDEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPLL 1026
Cdd:TIGR00914  955 FIRKLLEEGPS-----------LDEAVYEGALTRVRPVLMTALVASLGFVPMAIATGTGAEVQRPLATVVIGGIITATLL 1023

                         1050      1060
                   ....*....|....*....|..
gi 446496167  1027 SLFIIPAAYKLIWLRRHKKSVS 1048
Cdd:TIGR00914 1024 TLFVLPALYRLVHRRRHKGRKE 1045
CusA COG3696
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
1-1045 0e+00

Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];


Pssm-ID: 442911 [Multi-domain]  Cd Length: 1031  Bit Score: 1482.97  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167    1 MIEWIIRRSVANRFLVMMGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAK 80
Cdd:COG3696     1 MLNRIIRFSLRNRLLVLLLTLLLAAAGIYSLRRLPIDAFPDITNVQVQVITEAPGLSPEEVEQQVTYPIETALNGLPGVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   81 TVRGFSQFGDSYVYVIFEDGTDLYWARSRVLEYLNQVQGKLPAGVSSEIGPDATGVGWIFEYALVDRNGKHDLSELRSLQ 160
Cdd:COG3696    81 EVRSISRFGLSVVTVIFEDGTDIYWARQLVLERLQQVREQLPAGVTPELGPISTGLGEIYQYTLESDPGKYSLMELRTLQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  161 DWFLKFELKTIPNVAEVASVGGVVKQYQIQVNPVKLSQYGISLPEVKQALESSNQEAGGSSVEMAEAEYMVRASGYLQSI 240
Cdd:COG3696   161 DWVIRPQLRSVPGVAEVNSFGGFVKQYQVLVDPAKLRAYGLTLDDVIEALERNNANVGGGYIERGGQEYLVRGIGLIRSL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  241 DDFNNIVLKTgENGVPVYLRDVARVQTGPEMRRGIAELNGQGEVAGGVVILRSGKNARDVITAVRDKLETLKASLPEGVE 320
Cdd:COG3696   241 EDIENIVVKT-RNGTPVLLRDVAEVRIGPAPRRGAATLNGEGEVVGGIVLMLKGENALEVIEAVKAKLAELKPSLPEGVK 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  321 IVTTYDRSQLIDRAIDNLSSKLLEEFIVVAIVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIAIAV 400
Cdd:COG3696   320 IVPFYDRSDLIDRAIHTVTKNLLEGALLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLGGLAIDF 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  401 GAMVDAAIVMIENAHKRLEEWDHQHPGEQidnatRWKVITDASVEVGPALFISLLIITLSFIPIFTLEGQEGRLFGPLAF 480
Cdd:COG3696   400 GIIVDGAVVMVENILRRLEENRAAGTPRE-----RLEVVLEAAREVRRPIFFATLIIILVFLPIFTLEGVEGKLFRPMAL 474

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  481 TKTYSMAGAAALAIIVIPILMGFWIRGKIPaETSNPLNRVLIKAYHPLLLRVLHWPKTTLLVAALSIFTVIWPLSQVGGE 560
Cdd:COG3696   475 TVIFALLGALLLSLTLVPVLASLLLRGKVP-EKENPLVRWLKRLYRPLLRWALRHPKLVLAVALVLLVLALALFPRLGSE 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  561 FLPKINEGDLLYMPSTLPGVSPAEAAALLQTTDKLIKSVPEVASVFGKTGKAETATDSAPLEMVETTIQLKPEDQWRPGM 640
Cdd:COG3696   554 FLPELDEGDLLVMATLPPGISLEESVELGQQVERILKSFPEVESVVSRTGRAEDATDPMGVNMSETFVILKPRSEWRSGR 633

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  641 TIDKIIDELDRTV-RLPGLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTVLSDIDATAQSIEAVAKTVPGVVSVLAERLE 719
Cdd:COG3696   634 TKEELIAEMREALeQIPGVNFNFSQPIQMRVDELLSGVRADVAVKIFGDDLDVLRRLAEQIEAVLKTVPGAADVQVERVT 713

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  720 GGRYIDIDINREKASRYGMTVGDVQLFVSSAIGGAMVGETVEGVARYPINIRYPQDYRNSPQALKQMPILTPMKQQITLG 799
Cdd:COG3696   714 GLPQLDIRIDRDAAARYGLNVADVQDVVETAIGGKAVGQVYEGERRFDIVVRLPEELRDDPEAIRNLPIPTPSGAQVPLS 793

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  800 DVADINVVSGPTMLKTENARPASWIYVDARGRDMVSVVNDIKTAISEKVKLRPGTSVAFSGQFELLEHANKKLKLMVPMT 879
Cdd:COG3696   794 QVADIEVVEGPNQISRENGRRRIVVQANVRGRDLGSFVAEAQAKVAEQVKLPPGYYIEWGGQFENLQRATARLAIVVPLA 873

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  880 VMIIFILLYLAFRRVDEALLILMSLPFALVGGIWFLYWQGFHMSVATGTGFIALAGVAAEFGVVMLMYLRHAIEAHpels 959
Cdd:COG3696   874 LLLIFLLLYLAFGSVRDALLILLNVPFALIGGVLALWLRGMPLSVSAGVGFIALFGVAVLNGVVLVSYINQLRAEG---- 949

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  960 rketftpEGLDEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPLLSLFIIPAAYKLIW 1039
Cdd:COG3696   950 -------LDLREAIIEGALERLRPVLMTALVAALGLLPMALSTGPGSEVQRPLATVVIGGLITSTLLTLLVLPALYLLFG 1022


                  ....*.
gi 446496167 1040 LRRHKK 1045
Cdd:COG3696  1023 RRRLRR 1028
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
 1-1038 0e+00

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 719.46  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167     1 MIEWIIRRSVAnrflVMMGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAK 80
Cdd:pfam00873    1 MSKFFIRRPIF----TLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167    81 TVRGFSQFGDSYVYVIFEDGTDLYWARSRVLEYLNQVQGKLPAGVSS-EIGPDATGVGWIFEYALVDRNGKHDLSELRSL 159
Cdd:pfam00873   77 YMSSQSSYGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGVQRpGISVIKTSLGPIMVLAVTSPDGSYTQTDLRDY 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   160 QDWFLKFELKTIPNVAEVASVGGVVKQYQIQVNPVKLSQYGISLPEVKQALESSNQEAGGSSVEMAEAEYMVRASGYLQS 239
Cdd:pfam00873  157 ADTNIKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQS 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   240 IDDFNNIVLKtGENGVPVYLRDVARVQTGPEMRRGIAELNGQgEVAGGVVILRSGKNARDVITAVRDKLETLKASLPEGV 319
Cdd:pfam00873  237 AEDFEKIIVK-NQDGSPVRLRDVATVELGSELYRGFATFNGK-PAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQGV 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   320 EIVTTYDRSQLIDRAIDNLSSKLLEEFIVVAIVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIAIA 399
Cdd:pfam00873  315 EIVVVYDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLA 394

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   400 VGAMVDAAIVMIENAHKRLEEwDHQHPGEQIDNATRwkvitdasvEVGPALFISLLIITLSFIPIFTLEGQEGRLFGPLA 479
Cdd:pfam00873  395 IGLVVDDAIVVVENIERVLEE-NGLKPLEAAYKSMG---------EIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFA 464

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   480 FTKTYSMAGAAALAIIVIPILMGFWIRGKIPAE------TSNPLNRVLIKAYHPLLLRVLHWPKTTLLVAALSIFTVIWP 553
Cdd:pfam00873  465 ITIVLAILLSVLVALTLTPALCATLLKPRREPKhggffrWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWL 544

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   554 LSQVGGEFLPKINEGDLLYMPSTLPGVSPAEAAALLQTTDKLIKSVPEVASVFGKTGKAEtATDSAPLEMVETTIQLKPE 633
Cdd:pfam00873  545 FVRIPTEFLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFAF-SGDNNGPNSGDAFISLKPW 623

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   634 DQWR-PGMTIDKIIDELDRTVR-LPGLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTVLSDIDATAQSIEAVAKTVPGVV 711
Cdd:pfam00873  624 KERPgPEKSVQALIERLRKALKqIPGANVFLFQPIQLRGLGTISGFRSDLQVKIFGDDLDALDEARNQILAALAQLPGLS 703

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   712 SVLAERLEGGRYIDIDINREKASRYGMTVGDVQLFVSSAIGGAMVGETVEGVARYPINIRYPQDYRNSPQALKQMPILTP 791
Cdd:pfam00873  704 DVRSDGQEDQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYVRNP 783

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   792 MKQQITLGDVADINVVSGPTMLKTENARPASWIYVDARGRDMVSVVNDIKTAISEKVKLRPGTSVAFSGQFELLEHANKK 871
Cdd:pfam00873  784 YGKMIPLSAFAKIEWGYGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVKLPPGYGYTWTGQFEQEQLAGNS 863

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   872 LKLMVPMTVMIIFILLYLAFRRVDEALLILMSLPFALVGGIWFLYWQGFHMSVATGTGFIALAGVAAEFGVVMlmylrha 951
Cdd:pfam00873  864 LPILIALALLVVFLVLAALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILM------- 936

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   952 IEAHPELSRKETFTPEgldEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPLLSLFII 1031
Cdd:pfam00873  937 VEFANELREQEGKSLE---EAILEACRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVV 1013


                   ....*..
gi 446496167  1032 PAAYKLI 1038
Cdd:pfam00873 1014 PVFYVLF 1020
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
1-1038 0e+00

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 634.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167    1 MIEWIIRRSVAnrflVMMGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAK 80
Cdd:COG0841     3 LSRFFIRRPVA----AIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   81 TVRGFSQFGDSYVYVIFEDGTDLYWARSRVLEYLNQVQGKLPAGVS----SEIGPDATGVGWIfeyALvdRNGKHDLSEL 156
Cdd:COG0841    79 YITSTSSEGSSSITVEFELGTDIDEALVDVQNAVDRARSDLPEDVEppgvTKVNPSDFPVMVL---AL--SSDDLDELEL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  157 RSLQDWFLKFELKTIPNVAEVASVGGVVKQYQIQVNPVKLSQYGISLPEVKQALESSNQEAGGSSVEMAEAEYMVRASGY 236
Cdd:COG0841   154 SDYAERNIKDRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGR 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  237 LQSIDDFNNIVLKTGeNGVPVYLRDVARVQTGPEMRRGIAELNGQgEVAGGVVILRSGKNARDVITAVRDKLETLKASLP 316
Cdd:COG0841   234 LKTPEEFENIVIRTN-DGSVVRLGDVARVEDGAEDYRSIARLNGK-PAVGLAIQKQPGANALEVADAVRAKLEELQASLP 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  317 EGVEIVTTYDRSQLIDRAIDNLSSKLLEEFIVVAIVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGI 396
Cdd:COG0841   312 EGVELTIVYDQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFAL 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  397 AIAVGAMVDAAIVMIENAHKRLEEwdhqhpGEQIDNATRwkvitDASVEVGPALFISLLIITLSFIPIFTLEGQEGRLFG 476
Cdd:COG0841   392 VLAIGIVVDDAIVVVENIERHMEE------GLSPLEAAI-----KGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFR 460

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  477 PLAFTKTYSMAGAAALAIIVIPILMGFWIRGKIPAETSNPLNRV------LIKAYHPLLLRVLHWPKTTLLVAALSIFTV 550
Cdd:COG0841   461 QFALTVAIALLISLFVALTLTPALCARLLKPHPKGKKGRFFRAFnrgfdrLTRGYGRLLRWALRHRKLTLLVALALLALS 540

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  551 IWPLSQVGGEFLPKINEGDLLYMPSTLPGVSPAEAAALLQTTDKLIKSVPEVASVFGKTGKAETATDSApleMVETTIQL 630
Cdd:COG0841   541 VLLFGRLPTEFFPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSGGGSGSN---SGTIFVTL 617

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  631 KPEDQwRPgMTIDKIIDEL-DRTVRLPGL-ANLWVPPIRNRidmlstGIKSPIGIKVSGTVLSDIDATAQSIEAVAKTVP 708
Cdd:COG0841   618 KPWDE-RD-RSADEIIARLrEKLAKIPGArVFVFQPPAGGL------GSGAPIEVQLQGDDLEELAAAAEKLLAALRQIP 689

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  709 GVVSVLAERLEGGRYIDIDINREKASRYGMTVGDVQLFVSSAIGGAMVGETVEGVARYPINIRYPQDYRNSPQALKQMPI 788
Cdd:COG0841   690 GLVDVRSDLQLGKPELQLDIDREKAAALGVTVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLYV 769

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  789 LTPMKQQITLGDVADINVVSGPTMLKTENARPASWIYVD-ARGRDMVSVVNDIKTAISEkVKLRPGTSVAFSGQFELLEH 867
Cdd:COG0841   770 RTPDGEMVPLSSVATIEEGTGPSSINRYNGQRSVTVSANlAPGVSLGEALAAIEELAAE-LKLPPGVSIEFTGQAEEEQE 848

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  868 ANKKLKLMVPMTVMIIFILLYLAFRRVDEALLILMSLPFALVGGIWFLYWQGFHMSVATGTGFIALAGVAAEFGVVMLMY 947
Cdd:COG0841   849 SFSSLGLAFLLALLLVYLVLAAQFESFIQPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDF 928

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  948 LRHAIEahpelsrketftpEGLD--EALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPL 1025
Cdd:COG0841   929 ANQLRE-------------EGMSlrEAILEAARLRLRPILMTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTL 995

                        1050
                  ....*....|...
gi 446496167 1026 LSLFIIPAAYKLI 1038
Cdd:COG0841   996 LTLFVVPVLYVLL 1008
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
4-1038 2.04e-116

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 383.21  E-value: 2.04e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167    4 WIIRRSVANRFLVMMGALFlsiwGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAKTVR 83
Cdd:NF033617    3 VFIKRPVATLLLSLLILLL----GLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   84 GFSQFGDSYVYVIFEDGTDLYWARSRVLEYLNQVQGKLPAG-----VSSEIGPDATGVGWI-FEYALVDRNGKHDLSELR 157
Cdd:NF033617   79 SQSSLGYSTITLQFRLGTDLDVALSEVQAAINAAQSLLPSEapdppVYRKANSADTPIMYIgLTSEEMPRGQLTDYAERV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  158 slqdwfLKFELKTIPNVAEVASVGGVVKQYQIQVNPVKLSQYGISLPEVKQALESSNQEAGGSSVEMAEAEYMVRASGYL 237
Cdd:NF033617  159 ------LAPKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQL 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  238 QSIDDFNNIVLKTGENGVPVYLRDVARVQTGPEMRRGIAELNGQGEVAGGVVILrSGKNARDVITAVRDKLETLKASLPE 317
Cdd:NF033617  233 KTAEDYEDLVIKYADNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQ-PGANPIEVADEIRALLPELQETLPK 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  318 GVEIVTTYDRSQLIDRAIDNLSSKLLEEFIVVAIVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIA 397
Cdd:NF033617  312 NIKVNVLYDRTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALV 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  398 IAVGAMVDAAIVMIENAHKRLEEWDhqHPGEQIDNATRwkvitdasvEVGpalfISLLIITLS----FIPIFTLEGQEGR 473
Cdd:NF033617  392 LAIGLVVDDAIVVVENIHRHIEEGE--SPLEAALKGAR---------EIG----FTVIAMTLTlvavYLPILFMGGLTGR 456

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  474 LFGPLAFTktysMAGAAALAIIVIPIL---MGFWIRGKIPAEtsNPLNRV-------LIKAYHPLLLRVLHWPKTTLLVA 543
Cdd:NF033617  457 LFREFAVT----LAGAVIISGIVALTLtpmMCSRLLKANEKP--GRFARAvdrffdgLTARYGRGLKWVLKHRPLTLVVA 530

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  544 ALSIFTVIWPLSQVGGEFLPKINEGDLLympSTLPGVSPAEAAALLQTTDKL---IKSVPEVASVFGKTGKAETATDSAP 620
Cdd:NF033617  531 LATLALLPLLYVFIPKELAPSEDRGVIF---GMIQAPQSISLDYMSAKMRDVekiLSSDPEVQSLTSFNGVGGNPGDNTG 607

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  621 LEMvettIQLKPEDQWRpgMTIDKIIDELDRTV-RLPGLA-NLW-VPPIRnridmLSTGIKSPIGIKVSGTvlSDIDA-- 695
Cdd:NF033617  608 FGI----INLKPWDERD--VSAQEIIDRLRPKLaKVPGMDlFLFpLQDLP-----GGAGSSLPQYQVTLTP--SDYDSlf 674

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  696 -TAQSIEAVAKTVPGVVSVLAERLEGGRYIDIDINREKASRYGMTVGDVQLFVSSAIGGAMVGETVEGVARYPINIRYPQ 774
Cdd:NF033617  675 tWAEKLKEKLRKSPQFADVDSDLQDKGPELNVDIDRDKAARLGISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDR 754

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  775 DYRNSPQALKQMPILTPMKQQITLGDVADINVVSGPTMLKTENARPASWIYVD-ARGRDMVSVVNDIKTAISEKVKLrpG 853
Cdd:NF033617  755 RYRLNPEALNQIYVRSNDGKLVPLSTLAKIEERAAPLSLNHFNQFNSATLSFNlAPGVSLGEAIEALDQAAKELLPS--G 832

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  854 TSVAFSGQFELLEHANKKLKLMVPMTVMIIFILLYLAFRRVDEALLILMSLPFALVGGIWFLYWQGFHMSVATGTGFIAL 933
Cdd:NF033617  833 ISGSFQGAARAFQEEGSSLLFLFLLALAAIYLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGLITL 912

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  934 AGVAAEFGVVMlmylrhaIEAHPELSRKETFTPEgldEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIA 1013
Cdd:NF033617  913 IGLVKKNGILM-------VEFANELQRHQGLSRR---EAIYQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLG 982

                        1050      1060
                  ....*....|....*....|....*
gi 446496167 1014 APMIGGMITAPLLSLFIIPAAYKLI 1038
Cdd:NF033617  983 IVIVGGLGVGTLFTLFVLPVVYLLL 1007
2A0602 TIGR00915
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ...
 20-1038 3.95e-77

The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]


Pssm-ID: 273335 [Multi-domain]  Cd Length: 1044  Bit Score: 274.68  E-value: 3.95e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167    20 ALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAKTVRGFSQF-GDSYVYVIFE 98
Cdd:TIGR00915   16 AIIIMLAGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSSSSDSdGSMTITLTFE 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167    99 DGTDLYWARSRVLEYLNQVQGKLPAGVSSE-IGPDATGVGWIFEYALVDRNGKHDLSELRSLQDWFLKFELKTIPNVAEV 177
Cdd:TIGR00915   96 QGTDPDIAQVQVQNKLQLATPLLPQEVQRQgVRVEKASSNFLMVIGLVSDDGSMTKEDLSDYAASNMVDPLSRLEGVGDV 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   178 ASVGgvvKQY--QIQVNPVKLSQYGISLPEVKQALESSN-QEAGGS-----SVEMAEAEYMVRASGYLQSIDDFNNIVLK 249
Cdd:TIGR00915  176 QLFG---SQYamRIWLDPAKLNSYQLTPADVISAISAQNaQISAGQlgglpAVPGQQLNATIIAQTRLQTPEQFENILLK 252

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   250 TGENGVPVYLRDVARVQTGPEMRRGIAELNGQgEVAGGVVILRSGKNARDVITAVRDKLETLKASLPEGVEIVTTYDRSQ 329
Cdd:TIGR00915  253 VNTDGSQVRLKDVARVELGGENYSISARFNGK-PASGLAIKLATGANALDTAKAVKAELAVLEPFFPQGMKYVYPYDTTP 331

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   330 LIDRAIDNLSSKLLEEFIVVAIVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIAIAVGAMVDAAIV 409
Cdd:TIGR00915  332 FVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAMVLAIGLLVDDAIV 411

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   410 MIENAHKRLEEwDHQHPGEqidnATR--WKVITDASVEVGpalfislLIITLSFIPIFTLEGQEGRLFGPLAFTKTYSMA 487
Cdd:TIGR00915  412 VVENVERVMAE-EGLPPKE----ATRksMGQIQGALVGIA-------MVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMA 479

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   488 GAAALAIIVIPILMGFWIRGKIPAETS-------NPLNRVL---IKAYHPLLLRVLHWPKTTLLVAALSIFTVIWPLSQV 557
Cdd:TIGR00915  480 LSVLVALILTPALCATMLKPIEKGEHHekkggffGWFNRMFdssTHGYENGVGKILRRRGRYLLVYVLLVGGMVFLFVRL 559

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   558 GGEFLPKINEGDLLYMPSTLPGVSPAEAAALLQTTDK--LIKSVPEVASVFGKTGkAETATDSAPLEMVetTIQLKP-ED 634
Cdd:TIGR00915  560 PTSFLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKylLAKEKANVESVFTVNG-FSFAGRGQNMGMA--FIRLKDwEE 636

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   635 QWRPGMTIDKIIDELDR---TVRLPGLANLWVPPIRnridmlstGIKSPIGIKV-----SGTVLSDIDATAQSIEAVAKT 706
Cdd:TIGR00915  637 RTGKENSVFAIAGRATGhfmQIKDAMVIAFVPPAIL--------ELGNATGFDFflqdrAGLGHEALLQARNQLLGLAAQ 708

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   707 VPGVVSVLAERLEGGRYIDIDINREKASRYGMTVGDVQLFVSSAIGGAMVGETVEGVARYPINIRYPQDYRNSPQALKQM 786
Cdd:TIGR00915  709 NPALTRVRPNGLEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVNDFIDRGRVKRVYVQAEEDARMSPEDINKW 788

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   787 PILTPMKQQITLGDVADINVVSGPTMLKTENARPASWIYVDA-----RGRDMVSVVNDIKtaisekvKLRPGTSVAFSGQ 861
Cdd:TIGR00915  789 YVRNASGEMVPFSAFATVRWEYGSPQLERYNGLPSMEILGSAapgvsTGQAMAAMEAIAQ-------KLPPGFGFSWTGM 861

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   862 FELLEHANKKLKLMVPMTVMIIFILLYLAFRRVDEALLILMSLPFALVGGIWFLYWQGFHMSVATGTGFIALAGVAAEFG 941
Cdd:TIGR00915  862 SYEERLSGSQAPALYALSLLVVFLCLAALYESWSIPVSVMLVVPLGIIGALLATTLRGLSNDVYFQVGLLTTIGLSAKNA 941

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   942 VVMlmylrhaIEAHPELSRKEtftpEGLDEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMI 1021
Cdd:TIGR00915  942 ILI-------VEFAKELMAQG----KSIVEAALEAARLRLRPILMTSLAFILGVVPLAISTGAGSGSQHAIGTGVFGGMV 1010

                         1050
                   ....*....|....*..
gi 446496167  1022 TAPLLSLFIIPAAYKLI 1038
Cdd:TIGR00915 1011 TATVLAIFFVPLFYVVV 1027
PRK15127 PRK15127
multidrug efflux RND transporter permease subunit AcrB;
20-1046 1.00e-61

multidrug efflux RND transporter permease subunit AcrB;


Pssm-ID: 185081 [Multi-domain]  Cd Length: 1049  Bit Score: 229.02  E-value: 1.00e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   20 ALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAKTVRGFS-QFGDSYVYVIFE 98
Cdd:PRK15127   16 AIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSdSTGTVQITLTFE 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   99 DGTDLYWARSRVLEYLNQVQGKLPAGVSSE-IGPDATGVGWIFEYALVDRNGKHDLSELRSLQDWFLKFELKTIPNVAEV 177
Cdd:PRK15127   96 SGTDADIAQVQVQNKLQLAMPLLPQEVQQQgVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDPISRTSGVGDV 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  178 ASVGGvvkQY--QIQVNPVKLSQYGISLPEVKQALESSN------QEAGGSSVEMAEAEYMVRASGYLQSIDDFNNIVLK 249
Cdd:PRK15127  176 QLFGS---QYamRIWMNPNELNKFQLTPVDVINAIKAQNaqvaagQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKILLK 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  250 TGENGVPVYLRDVARVQTGPEMRRGIAELNGQgEVAGGVVILRSGKNARDVITAVRDKLETLKASLPEGVEIVTTYDRSQ 329
Cdd:PRK15127  253 VNQDGSRVRLRDVAKIELGGENYDIIAEFNGQ-PASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTTP 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  330 LIDRAIDNLSSKLLEEFIVVAIVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIAIAVGAMVDAAIV 409
Cdd:PRK15127  332 FVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIV 411

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  410 MIENAHKRLEEwdhqhPGEQIDNATRWKVITDASVEVGPALFISLLiitlsFIPIFTLEGQEGRLFGPLAFTKTYSMAGA 489
Cdd:PRK15127  412 VVENVERVMAE-----EGLPPKEATRKSMGQIQGALVGIAMVLSAV-----FVPMAFFGGSTGAIYRQFSITIVSAMALS 481

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  490 AALAIIVIPILMGFWIR-------GKIPAETSNPLNRVLIKAYHPLLLRVLHWPKTT---LLVAALSIFTVIWPLSQVGG 559
Cdd:PRK15127  482 VLVALILTPALCATMLKpiakgdhGEGKKGFFGWFNRMFEKSTHHYTDSVGNILRSTgryLVLYLIIVVGMAYLFVRLPS 561

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  560 EFLPKINEGDLLYMPSTLPGVSPAEAAALL-QTTDK-LIKSVPEVASV-----FGKTGKAETATDSaplemvetTIQLKP 632
Cdd:PRK15127  562 SFLPDEDQGVFLTMVQLPAGATQERTQKVLnEVTDYyLTKEKNNVESVfavngFGFAGRGQNTGIA--------FVSLKD 633

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  633 EDQwRPG-------------MTIDKIIDELDRTVRLPGLANLWVppirnridmlSTGIKSPIgIKVSGTVLSDI-DATAQ 698
Cdd:PRK15127  634 WAD-RPGeenkveaitmratRAFSQIKDAMVFAFNLPAIVELGT----------ATGFDFEL-IDQAGLGHEKLtQARNQ 701

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  699 SIEAVAKTVPGVVSVLAERLEGGRYIDIDINREKASRYGMTVGDVQLFVSSAIGGAMVGETVEGVARYPINIRYPQDYRN 778
Cdd:PRK15127  702 LLGEAAKHPDMLVGVRPNGLEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRM 781

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  779 SPQALKQMPILTPMKQQITLGDVADINVVSGPTMLKTENARPASWIYVDA-RGRDMVSVVNDIKTAISekvKLRPGTSVA 857
Cdd:PRK15127  782 LPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAaPGKSTGEAMELMEELAS---KLPTGVGYD 858

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  858 FSGQFELLEHANKKLKLMVPMTVMIIFILLYLAFRRVDEALLILMSLPFALVGGIWFLYWQGFHMSVATGTGFIALAGVA 937
Cdd:PRK15127  859 WTGMSYQERLSGNQAPALYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLS 938

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  938 AEFGVVMlmylrhaIEAHPELSRKETftpEGLDEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMI 1017
Cdd:PRK15127  939 AKNAILI-------VEFAKDLMDKEG---KGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVM 1008

                        1050      1060
                  ....*....|....*....|....*....
gi 446496167 1018 GGMITAPLLSLFIIPAAYKLIWLRRHKKS 1046
Cdd:PRK15127 1009 GGMVTATVLAIFFVPVFFVVVRRRFSRKN 1037
PRK09579 PRK09579
multidrug efflux RND transporter permease subunit;
6-1038 1.11e-61

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169983 [Multi-domain]  Cd Length: 1017  Bit Score: 228.57  E-value: 1.11e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167    6 IRRSVanrfLVMMGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAKTVRGF 85
Cdd:PRK09579    8 IRRPV----LASVVSLLIVLLGFQAWSKLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYMTSV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   86 SQFGDSYVYVIFEDGTDLYWARSRVLEYLNQVQGKLPAG----VSSEIGPDATGVGWIFEYALVDRNGKHDLSELRSLQD 161
Cdd:PRK09579   84 SRQNFSIISIYARIGADSDRLFTELLAKANEVKNQLPQDaedpVLSKEAADASALMYISFYSEEMSNPQITDYLSRVIQP 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  162 wflkfELKTIPNVAEVASVGGVVKQYQIQVNPVKLSQYGISLPEVKQALESSNQEAGGSSVEmaeAEYMV---RASGYLQ 238
Cdd:PRK09579  164 -----KLATLPGMAEAEILGNQVFAMRLWLDPVKLAGFGLSAGDVTQAVRRYNFLSAAGEVK---GEYVVtsiNASTELK 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  239 SIDDFNNIVLKTGENGvPVYLRDVARVQTGPEMRRGIAELNGQGEVAGGVVILRSGkNARDVITAVRDKLETLKASLPEG 318
Cdd:PRK09579  236 SAEAFAAIPVKTSGDS-RVLLGDVARVEMGAENYDSISSFDGIPSVYIGIKATPSA-NPLDVIKEVRAIMPELESQLPPN 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  319 VEIVTTYDRSQLIDRAIDNLSSKLLEEFIVVAIVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIAI 398
Cdd:PRK09579  314 LKVSIAYDATLFIQASIDEVVKTLGEAVLIVIVVVFLFLGALRSVLIPVVTIPLSMIGVLFFMQMMGYSINLLTLLAMVL 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  399 AVGAMVDAAIVMIENAHKRLEEwdhqhpgeqidnatrWKVITDASVEVGP--ALFISLLIITLS--FIPIFTLEGQEGRL 474
Cdd:PRK09579  394 AIGLVVDDAIVVVENIHRHIEE---------------GKSPFDAALEGAReiAMPVVSMTITLAavYAPIGFLTGLTGAL 458

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  475 FGPLAFTktysMAGAAALAIIVI----PILMGFWIR-GKIPAETSNPLNRV---LIKAYHPLLLRVLHwPKTTLLVAALS 546
Cdd:PRK09579  459 FKEFALT----LAGAVIISGIVAltlsPMMCALLLRhEENPSGLAHRLDRLferLKQRYQRALHGTLN-TRPVVLVFAVI 533

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  547 IFTVIwP--LSQVGGEFLPKINEGdLLYMPSTLPgvSPAEAAALLQTTD---KLIKSVPEVASVFGKTGkaetatdsapL 621
Cdd:PRK09579  534 VLALI-PvlLKFTQSELAPEEDQG-IIFMMSSSP--QPANLDYLNAYTDeftPIFKSFPEYYSSFQING----------F 599

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  622 EMVETTIQ---LKPedqWrpgmtidkiiDELDRTvrlpglANLWVPPIRNRIDMLStgikspiGIKVSGTVLSDIDATAQ 698
Cdd:PRK09579  600 NGVQSGIGgflLKP---W----------NERERT------QMELLPLVQAKLEEIP-------GLQIFGFNLPSLPGTGE 653

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  699 SI--EAVAKTVPGVVSVL--AER-----LEGGRY----ID---------IDINREKASRYGMTVGDVQLFVSSAIGGAMV 756
Cdd:PRK09579  654 GLpfQFVINTANDYESLLqvAQRvkqraQESGKFafldIDlafdkpevvVDIDRAKAAQMGVSMQDLGGTLATLLGEGEI 733

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  757 GE-TVEGVArYPINIRYPQDYRNSPQALKQMPILTPMKQQITLGDVADINVVSGPTMLKTENARPASWIyvdaRGRDMVS 835
Cdd:PRK09579  734 NRfTIDGRS-YKVIAQVERPYRDNPGWLNNYYVKNEQGQLLPLSTLITLSDRARPRQLNQFQQLNSAII----SGFPIVS 808

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  836 VVNDIKT--AISEKvKLRPGTSVAFSGQFELLEHANKKLKLMVPMTVMIIFILLYLAFRRVDEALLILMSLPFALVGGIW 913
Cdd:PRK09579  809 MGEAIETvqQIARE-EAPEGFAFDYAGASRQYVQEGSALWVTFGLALAIIFLVLAAQFESFRDPLVILVTVPLSICGALI 887

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  914 FLYWQGFHMSVATGTGFIALAGVAAEFGVVMlmylrhaIEAHPELSRKETFTPEgldEALYHGAVLRVRPKAMTVAVIIA 993
Cdd:PRK09579  888 PLFLGVSSMNIYTQVGLVTLIGLISKHGILI-------VEFANQLRHEQGLSRR---EAIEEAAAIRLRPVLMTTAAMVF 957

                        1050      1060      1070      1080
                  ....*....|....*....|....*....|....*....|....*
gi 446496167  994 GLLPILWGTGAGSEVMSRIAAPMIGGMITAPLLSLFIIPAAYKLI 1038
Cdd:PRK09579  958 GMVPLILATGAGAVSRFDIGLVIATGMSIGTLFTLFVLPCIYTLL 1002
PRK09577 PRK09577
multidrug efflux RND transporter permease subunit;
20-1038 4.92e-57

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169981 [Multi-domain]  Cd Length: 1032  Bit Score: 214.33  E-value: 4.92e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   20 ALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAKTVRGFSQFGDSYVYVIFED 99
Cdd:PRK09577   16 SLFIMLGGIFAIRALPVAQYPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNGAPGLLYTSATSSAGQASLSLTFKQ 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  100 GTDLYWARSRVLEYLNQVQGKLP-----AGVSSEIGPDATGVgwifEYALVDRNGKHDLSELRSLQDWFLKFELKTIPNV 174
Cdd:PRK09577   96 GVNADLAAVEVQNRLKTVEARLPepvrrDGIQVEKAADNIQL----IVSLTSDDGRLTGVELGEYASANVLQALRRVEGV 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  175 AEVASVGGvvkQYQIQV--NPVKLSQYGISLPEVKQALESSNQ-----EAGGSSV-EMAEAEYMVRASGYLQSIDDFNNI 246
Cdd:PRK09577  172 GKVQFWGA---EYAMRIwpDPVKLAALGLTASDIASAVRAHNArvtigDIGRSAVpDSAPIAATVFADAPLKTPEDFGAI 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  247 VLKTGENGVPVYLRDVARVQTGPEMRRGIAELNGQgeVAGGVVI-LRSGKNARDVITAVRDKLETLKASLPEGVEIVTTY 325
Cdd:PRK09577  249 ALRARADGSALYLRDVARIEFGGNDYNYPSYVNGK--TATGMGIkLAPGSNAVATEKRVRATMDELSRYFPPGVKYQIPY 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  326 DRSQLIDRAIDNLSSKLLEEFIVVAIVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIAIAVGAMVD 405
Cdd:PRK09577  327 ETSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMQNFRATLIPTLVVPVALLGTFGVMLAAGFSINVLTMFGMVLAIGILVD 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  406 AAIVMIENAHKRLEEwdhqhpgeqiDNATRWKVITDASVEVGPALFISLLIITLSFIPIFTLEGQEGRLFGPLAFTKTYS 485
Cdd:PRK09577  407 DAIVVVENVERLMVE----------EGLSPYDATVKAMKQISGAIVGITVVLTSVFVPMAFFGGAVGNIYRQFALSLAVS 476

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  486 MAGAAALAIIVIPILM---------------GF--WIRGKIPAETSNPLNRVlikayHPLLLRVLHWpkttLLVAALSIF 548
Cdd:PRK09577  477 IGFSAFLALSLTPALCatllkpvdgdhhekrGFfgWFNRFVARSTQRYATRV-----GAILKRPLRW----LVVYGALTA 547

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  549 TVIWPLSQVGGEFLPKINEGDLLYMPSTLPGVSPAEAAALLQTTDKLIKSVPEVASVFGKTGKA--ETATDSApleMVET 626
Cdd:PRK09577  548 AAALLFTRLPTAFLPDEDQGNFMVMVIRPQGTPLAETMQSVREVESYLRRHEPVAYTFALGGFNlyGEGPNGG---MIFV 624

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  627 TIQLKPEDQwRPGMTIDKIIDELDrtVRLPGLANLWV-----PPIRnriDMLSTG-----IKSPIGIKVSGTVlsdidAT 696
Cdd:PRK09577  625 TLKDWKERK-AARDHVQAIVARIN--ERFAGTPNTTVfamnsPALP---DLGSTSgfdfrLQDRGGLGYAAFV-----AA 693

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  697 AQSIEAVAKTVPGVVSVLAERLEGGRYIDIDINREKASRYGMTVGDVQLFVSSAIGGAMVGETVEGVARYPINIRYPQDY 776
Cdd:PRK09577  694 REQLLAEGAKDPALTDLMFAGTQDAPQLKLDIDRAKASALGVSMDEINTTLAVMFGSDYIGDFMHGSQVRRVIVQADGRH 773

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  777 RNSPQALKQMPILTPMKQQITLGDVADINVVSGPTMLKTENARPASWIYVDAR-GRDMVSVVNDIKTAISekvKLRPGTS 855
Cdd:PRK09577  774 RLDPDDVKKLRVRNAQGEMVPLAAFATLHWTLGPPQLTRYNGYPSFTINGSAApGHSSGEAMAAIERIAA---TLPAGIG 850

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  856 VAFSGQFELLEHANKKLKLMVPMTVMIIFILLYLAFRRVDEALLILMSLPFALVGGIWFLYWQGFHMSVATGTGFIALAG 935
Cdd:PRK09577  851 YAWSGQSFEERLSGAQAPMLFALSVLVVFLALAALYESWSIPFAVMLVVPLGVIGAVLGVTLRGMPNDIYFKVGLIATIG 930

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  936 VAAEFGVVMLmylrhaieahpELSRKETFTPEGLDEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAP 1015
Cdd:PRK09577  931 LSAKNAILIV-----------EVAKDLVAQRMSLADAALEAARLRLRPIVMTSLAFGVGVLPLAFASGAASGAQIAIGTG 999

                        1050      1060
                  ....*....|....*....|...
gi 446496167 1016 MIGGMITAPLLSLFIIPAAYKLI 1038
Cdd:PRK09577 1000 VLGGVITATVLAVFLVPLFFVVV 1022
PRK10614 PRK10614
multidrug efflux system subunit MdtC; Provisional
 6-1048 1.67e-56

multidrug efflux system subunit MdtC; Provisional


Pssm-ID: 182589 [Multi-domain]  Cd Length: 1025  Bit Score: 212.66  E-value: 1.67e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167    6 IRRSVANRFLvmmgALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAKTVRGF 85
Cdd:PRK10614    8 IYRPVATILL----SLAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   86 SQFGDSYVYVIFEDGTDLYWARSRVLEYLNQVQGKLPAGVSS-----EIGP-DATgvgwIFEYALV-DRNGKHDLSELRS 158
Cdd:PRK10614   84 SSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSrptyrKANPsDAP----IMILTLTsDTYSQGQLYDFAS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  159 LQdwfLKFELKTIPNVAEVASVGGVVKQYQIQVNPVKLSQYGISLPEVKQALESSNQEAGGSSVEMAEAEYMVRASGYLQ 238
Cdd:PRK10614  160 TQ---LAQTISQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRQAISNANVRRPQGAVEDGTHRWQIQTNDELK 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  239 SIDDFNNIVLKTgENGVPVYLRDVARVQTGPEMRRGIAELNGQGEVAggVVILRS-GKNARDVITAVRDKLETLKASLPE 317
Cdd:PRK10614  237 TAAEYQPLIIHY-NNGAAVRLGDVATVTDSVQDVRNAGMTNAKPAIL--LMIRKLpEANIIQTVDRIRAKLPELRETIPA 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  318 GVEIVTTYDRSQLIDRAIDNLSSKLLEEFIVVAIVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIA 397
Cdd:PRK10614  314 AIDLQIAQDRSPTIRASLEEVEQTLAISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALT 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  398 IAVGAMVDAAIVMIENAHKRLEEwdHQHPGEQIDNATRwkvitdasvEVG-PALFISLLIITLsFIPIFTLEGQEGRLFG 476
Cdd:PRK10614  394 IATGFVVDDAIVVLENISRHLEA--GMKPLQAALQGVR---------EVGfTVLSMSLSLVAV-FLPLLLMGGLPGRLFR 461

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  477 PLAFTKTYSMAGAAALAIIVIPILMGFWIRGKIPAETSNP--LNRVLIK---AYHPLLLRVLHWPKTTLLVAALSIFTVI 551
Cdd:PRK10614  462 EFAVTLSVAIGISLLVSLTLTPMMCAWLLKSSKPREQKRLrgFGRMLVAlqqGYGRSLKWVLNHTRWVGVVLLGTIALNV 541

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  552 WPLSQVGGEFLPKINEGDLLYMPSTLPGVSPAEAAALLQTTDKLIKSVPEVASVFGKTGKAETATDSaplemveTTIQLK 631
Cdd:PRK10614  542 WLYISIPKTFFPEQDTGRLMGFIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNSGM-------MFITLK 614

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  632 PEDQwrPGMTIDKIIDEL-DRTVRLPGlANLWVPPIRnriDMLSTGIKSPIGIKVsgTVLSDIDATAQSIEAVAK----T 706
Cdd:PRK10614  615 PLSE--RSETAQQVIDRLrVKLAKEPG-ANLFLMAVQ---DIRVGGRQSNASYQY--TLLSDDLAALREWEPKIRkalaA 686

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  707 VPGVVSVLAERLEGGRYIDIDINREKASRYGMTVGDVQLFVSSAIGGAMVGETVEGVARYPINIRYPQDYRNSPQALKQM 786
Cdd:PRK10614  687 LPELADVNSDQQDKGAEMALTYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPLNQYKVVMEVDPRYTQDISALEKM 766

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  787 PILTPMKQQITLGDVADINVVSGPTMLKTENARPASWIYVD-ARGRDMVSVVNDIKTAISEkvkLRPGTSV--AFSGQFE 863
Cdd:PRK10614  767 FVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSAASTISFNlPTGKSLSDASAAIERAMTQ---LGVPSTVrgSFAGTAQ 843

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  864 LLEHANKKLKLMVPMTVMIIFILLYLAFRRVDEALLILMSLPFALVGGIWFLYWQGFHMSVatgtgfIALAGVAAEFGVV 943
Cdd:PRK10614  844 VFQETMNSQLILILAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSL------IALIGIMLLIGIV 917

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  944 ---MLMYLRHAIEAHpelsRKETFTPEgldEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGM 1020
Cdd:PRK10614  918 kknAIMMVDFALEAQ----RNGNLTAQ---EAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGAELRQPLGITIVGGL 990

                        1050      1060      1070
                  ....*....|....*....|....*....|....
gi 446496167 1021 ITAPLLSLFIIPAAY------KLIWLRRHKKSVS 1048
Cdd:PRK10614  991 VMSQLLTLYTTPVVYlffdrlRLRFSRKPKQTVT 1024
PRK10555 PRK10555
multidrug efflux RND transporter permease AcrD;
20-1042 2.16e-55

multidrug efflux RND transporter permease AcrD;


Pssm-ID: 182544 [Multi-domain]  Cd Length: 1037  Bit Score: 209.30  E-value: 2.16e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   20 ALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAKTVRG-FSQFGDSYVYVIFE 98
Cdd:PRK10555   16 AILLCLTGTLAIFSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSqSSGTGQASVTLSFK 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   99 DGTDLYWARSRVLEYLNQVQGKLPAGVSSE-IGPDATGVGWIFEYALVDRNG---KHDLSEL--RSLQDwflkfELKTIP 172
Cdd:PRK10555   96 AGTDPDEAVQQVQNQLQSAMRKLPQAVQNQgVTVRKTGDTNILTIAFVSTDGsmdKQDIADYvaSNIQD-----PLSRVN 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  173 NVAEVASVGgvvKQY--QIQVNPVKLSQYGISLPEVKQALESSN------QEAGGSSVEMAEAEYMVRASGYLQSIDDFN 244
Cdd:PRK10555  171 GVGDIDAYG---SQYsmRIWLDPAKLNSFQMTTKDVTDAIESQNaqiavgQLGGTPSVDKQALNATINAQSLLQTPEQFR 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  245 NIVLKTGENGVPVYLRDVARVQTGPEMRRGIAELNGQgEVAGGVVILRSGKNARDVITAVRDKLETLKASLPEGVEIVTT 324
Cdd:PRK10555  248 DITLRVNQDGSEVTLGDVATVELGAEKYDYLSRFNGK-PASGLGVKLASGANEMATAKLVLNRLDELAQYFPHGLEYKVA 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  325 YDRSQLIDRAIDNLSSKLLEEFIVVAIVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIAIAVGAMV 404
Cdd:PRK10555  327 YETTSFVKASIEDVVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGYSINTLTMFAMVLAIGLLV 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  405 DAAIVMIENAHKRLEEwdhqhPGEQIDNATRWKVITDASVEVGPALFISLLiitlsFIPIFTLEGQEGRLFGPLAFTKTY 484
Cdd:PRK10555  407 DDAIVVVENVERIMSE-----EGLTPREATRKSMGQIQGALVGIAMVLSAV-----FVPMAFFGGTTGAIYRQFSITIVS 476

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  485 SMAGAAALAIIVIPILMGFWIRGKIPAETSNP------LNRVLIKA---YHPLLLRVLHWPKTTLLVAALSIFTVIWPLS 555
Cdd:PRK10555  477 AMVLSVLVAMILTPALCATLLKPLKKGEHHGQkgffgwFNRMFNRNaerYEKGVAKILHRSLRWILIYVLLLGGMVFLFL 556

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  556 QVGGEFLPKINEGDLLYMPSTLPGVSPAEAAALLQTTDK--LIKSVPEVASVFGKTGKAETATDSAPLEMVettIQLKPE 633
Cdd:PRK10555  557 RLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVEKVEKyyFTHEKDNVMSVFATVGSGPGGNGQNVARMF---IRLKDW 633

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  634 DQwRPGM--TIDKIIDELDRTVRLPGLANLWV--PPIrnridmlSTGIKSPIGIKVSgtvLSD---------IDATAQSI 700
Cdd:PRK10555  634 DE-RDSKtgTSFAIIERATKAFNKIKEARVIAssPPA-------ISGLGSSAGFDME---LQDhagaghdalMAARNQLL 702

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  701 EAVAKTvPGVVSVLAERLEGGRYIDIDINREKASRYGMTVGDVQLFVSSAIGGAMVGETVEGVARYPINIRYPQDYRNSP 780
Cdd:PRK10555  703 ALAAKN-PELTRVRHNGLDDSPQLQIDIDQRKAQALGVSIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAPYRMLP 781

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  781 QALKQMPILTPMKQQITLGDVADINVVSGPTMLKTENARPAswiyVDARGRDMVSVVNDIKTAISEKV--KLRPGTSVAF 858
Cdd:PRK10555  782 DDINLWYVRNKDGGMVPFSAFATSRWETGSPRLERYNGYSA----VEIVGEAAPGVSTGTAMDIMESLvkQLPNGFGLEW 857

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  859 SGQFELLEHANKKLKLMVPMTVMIIFILLYLAFRRVDEALLILMSLPFALVGGIWFLYWQGFHMSVATGTGFIALAGVAA 938
Cdd:PRK10555  858 TAMSYQERLSGAQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSA 937

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  939 EFGVVMlmylrhaIEAHPELSRKEtftpEGLDEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIG 1018
Cdd:PRK10555  938 KNAILI-------VEFANEMNQKG----HDLFEATLHASRQRLRPILMTSLAFIFGVLPMATSTGAGSGSQHAVGTGVMG 1006

                        1050      1060
                  ....*....|....*....|....
gi 446496167 1019 GMITAPLLSLFIIPAAYklIWLRR 1042
Cdd:PRK10555 1007 GMISATILAIFFVPLFF--VLVRR 1028
PRK10503 PRK10503
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
6-1044 1.06e-50

MdtB/MuxB family multidrug efflux RND transporter permease subunit;


Pssm-ID: 182501 [Multi-domain]  Cd Length: 1040  Bit Score: 194.95  E-value: 1.06e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167    6 IRRSVANRfLVMMGALFLSIWGTWTIintPVDALP--DLSDVQVIikTSYPGQAPQIVENQVTYPLTTTMLSVPGAKTVR 83
Cdd:PRK10503   17 ILRPVATT-LLMVAILLAGIIGYRAL---PVSALPevDYPTIQVV--TLYPGASPDVMTSAVTAPLERQFGQMSGLKQMS 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   84 GFSQFGDSYVYVIFEDGTDLYWARSRVLEYLNQVQGKLPAG-----VSSEIGP-DATGVGWIFEYALVDRNGKHDLSELR 157
Cdd:PRK10503   91 SQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDlpnppVYSKVNPaDPPIMTLAVTSTAMPMTQVEDMVETR 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  158 SLQdwflkfELKTIPNVAEVASVGGVVKQYQIQVNPVKLSQYGISLPEVKQALESSNQEAGGSSVEMAEAEYMVRASGYL 237
Cdd:PRK10503  171 VAQ------KISQVSGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPTRAVTLSANDQM 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  238 QSIDDFNNIVLkTGENGVPVYLRDVARVQTGPEMRRGIAELNGQGEVAGGVViLRSGKNARDVITAVRDKLETLKASLPE 317
Cdd:PRK10503  245 QSAEEYRQLII-AYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQ-RQPGANIIATADSIRQMLPQLTESLPK 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  318 GVEIVTTYDRSQLIDRAIDNLSSKLLEEFIVVAIVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIA 397
Cdd:PRK10503  323 SVKVTVLSDRTTNIRASVDDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALT 402

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  398 IAVGAMVDAAIVMIENAHKRLEEwdhqhpGEqidnatrwKVITDASVEVGPalfISLLIITLSF------IPIFTLEGQE 471
Cdd:PRK10503  403 IATGFVVDDAIVVIENISRYIEK------GE--------KPLAAALKGAGE---IGFTIISLTFsliavlIPLLFMGDIV 465

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  472 GRLFGPLAFTKTYSMAGAAALAIIVIPILMGFWIRgkipAETSNPLNRV----------LIKAYHPLLLRVLHWPKTTLL 541
Cdd:PRK10503  466 GRLFREFAVTLAVAILISAVVSLTLTPMMCARMLS----QESLRKQNRFsrasermfdrVIAAYGRGLAKVLNHPWLTLS 541

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  542 VA--ALSIFTVIWPLSQVGgeFLPKINEGDL---LYMPSTLPGVSPAEAAAllQTTDKLIK--SVPEVASVFGKTGkAET 614
Cdd:PRK10503  542 VAlsTLLLTVLLWIFIPKG--FFPVQDNGIIqgtLQAPQSSSFANMAQRQR--QVADVILQdpAVQSLTSFVGVDG-TNP 616

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  615 ATDSAPLEmvettIQLKPEDQWRPgmTIDKIIDELDRTV-RLPGlANLWVPPIRN-RIDMLSTgiKSPIGIKVSGTVLSD 692
Cdd:PRK10503  617 SLNSARLQ-----INLKPLDERDD--RVQKVIARLQTAVaKVPG-VDLYLQPTQDlTIDTQVS--RTQYQFTLQATSLDA 686

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  693 IDATAQSIEAVAKTVPGVVSVLAERLEGGRYIDIDINREKASRYGMTVGDVQLFVSSAIGGAMVGETVEGVARYPINIRy 772
Cdd:PRK10503  687 LSTWVPKLMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLE- 765

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  773 pQDYRNSP--QALKQMPILTPMKQQITLGDVADINVVSGPTMLKTENARPASWIYVD-ARGRDMVSVVNDIKTAiSEKVK 849
Cdd:PRK10503  766 -HNTENTPglAALDTIRLTSSDGGVVPLSSIATIEQRFGPLSINHLDQFPSTTISFNvPDGYSLGDAVQAIMDT-EKTLN 843

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  850 LRPGTSVAFSGQFELLEHANKKLKLMVPMTVMIIFILLYLAFRRVDEALLILMSLPFALVGGIWFLYWQGFHMSVATGTG 929
Cdd:PRK10503  844 LPADITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGVLYESFIHPITILSTLPTAGVGALLALMIAGSELDVIAIIG 923

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  930 FIALAGVAAEFGVVMLMYlrhAIEAHpelsRKETFTPEgldEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVM 1009
Cdd:PRK10503  924 IILLIGIVKKNAIMMIDF---ALAAE----REQGMSPR---DAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELR 993

                        1050      1060      1070      1080
                  ....*....|....*....|....*....|....*....|
gi 446496167 1010 SRIAAPMIGGMITAPLLSLFIIPAAYKLI-----WLRRHK 1044
Cdd:PRK10503  994 RPLGICMVGGLIVSQVLTLFTTPVIYLLFdrlalYTKSRF 1033
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
153-506 2.14e-09

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 61.41  E-value: 2.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  153 LSELRSLQDWflkfeLKTIPNVAEVASVGGVVKQYQIQVNPVKLSQYGIslPEVKqalessnqeaggssvEMAEAEYMVR 232
Cdd:COG1033   475 LKEIDRLQDY-----LESLPEVGKVLSLADLVKELNQALNEGDPKYYAL--PESR---------------ELLAQLLLLL 532

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  233 ASGYLQSIDDFNN-------IVLKTGENGVPVYLRDVARVQTgpEMRRGIAELNGQGEVAGGVVILRSGknardvitavr 305
Cdd:COG1033   533 SSPPGDDLSRFVDedysaarVTVRLKDLDSEEIKALVEEVRA--FLAENFPPDGVEVTLTGSAVLFAAI----------- 599

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  306 dkLETLKASLPEGVEIVttydrsqlidraidnlssklleeFIVVAIVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQG 385
Cdd:COG1033   600 --NESVIESQIRSLLLA-----------------------LLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLG 654

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  386 LNANIMSLGGIAIAVGAMVDAAIVMIEnahkRLEEwdhqhpgEQIDNATRWKVITDASVEVGPALFISLLIITLSFIP-I 464
Cdd:COG1033   655 IPLNIATAVVASIALGIGVDYTIHFLS----RYRE-------ERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVlL 723

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 446496167  465 F-TLEGQegRLFGPL-AFTktysMAGAAALAIIVIPILMGFWIR 506
Cdd:COG1033   724 FsSFPPL--ADFGLLlALG----LLVALLAALLLLPALLLLLDP 761
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
 260-968 1.43e-08

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 59.21  E-value: 1.43e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   260 RDVARVQ---TGPEMRRGIAelNGQGEVAGGVVILRSGKN---ARDVITAVRDKLETLKAslPEGVEIV------TTYDR 327
Cdd:TIGR00833   92 MHVISVVdfwGPPEAAEGLR--SDDGKATIIIVNLAGEKGqkeAQEAINAVRRIVEQTNA--PDGLTVHvtgplaTIADI 167

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   328 SQLIDRAIDNLSSKLLeefIVVAIVCALFLWHVRSALVAIISLPLGLCIAFIVM----HFQGLNANIMSLGGI-AIAVGA 402
Cdd:TIGR00833  168 LESGDKDMNRITATTG---IIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVsllgIPGLIGVNAQTTVLLtALVIGA 244

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   403 MVDAAIVMIENAHKRLEEwdHQHPGEQIDNATRwkvitdasvEVGPALFISLLIITLSFIPI-FTLEGQEGRLFGPLAFT 481
Cdd:TIGR00833  245 GTDYAVFLTGRYHEERRK--GESLEEAAAEALR---------GTGKAILGSALTVAVAFLALsLARLPSFKTLGVSCAVG 313

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   482 KTYSMAGAAAL--AIIVIPILMGFWIRGKiPAETSNPLNRvlikayhpLLLRVLHWPkTTLLVAALSIFTVIwplsqVGG 559
Cdd:TIGR00833  314 VLVALLNAVTLtpALLTLEGREGLMKPGR-KSKIRFIWRR--------LGTAVVRRP-WPILVTTLIISGVS-----LLA 378

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   560 EFLPKINEGDLLYMPSTLPGVSPAEAA-------------------------ALLQTTDKL---IKSVPEVASVFGKTGK 611
Cdd:TIGR00833  379 LPLIRTGYDDEKMIPTDLESVQGYEAAdrhfpgnsmdpmvvmiksdhdvrnpALLADIDRFereIKAVPGINMVQETQRP 458

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   612 AETATDSAPL---------EMVETTIQLKPEDQWRPGM--TIDKIIDELDRTVRLPGLANLWVPPIRNRIDMLSTGIK-- 678
Cdd:TIGR00833  459 DGVVIKKTYLtfqagnlgdQLDEFSDQLTSRQAYLLQDaeKIAEAIAGLRLVQAGMRLDGENLGQVSLAVRLMQQAISkl 538

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   679 -----------SPIGIKVSGTVLSDIDATAQSIEAVAKTVPGVVSVLAERLEggryIDIDINREKASRYGMTVGDVQLFV 747
Cdd:TIGR00833  539 qgsagdvfdifDPLRRFVAAIPECRANPVCSVAREIVQAADTVVSSAAKLAD----AAGQLARGIADVASALSQVSGLPN 614

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   748 SSAIGGAMVGETVEGVARYPINIRYPQDYRNSPQALKQ--MPILTPMKQQItLGDVADINVVSGPTMLKTENARPASWIY 825
Cdd:TIGR00833  615 ALDGIGTQLAQMRESAAGVQDLLNELSDYSMTMGKLKGnaMGVDFYAPPRI-FTDPNFKAVLDYFLSPDGHAARLLVYGD 693

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   826 VDARGRDMVSVVNDIKTAISEKVKLR--PGTSVAFSGQ----FELLEHANKKLKLMVPMTVMIIFILLYLAFRRVDEALL 899
Cdd:TIGR00833  694 GSPAGDQGAQEFNAIRTVAEEAIQRAdlEPAKVELAGVsavnRDLRDLVNSDLGLISIITLAIVFMILALLLRAPVAPIV 773

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446496167   900 ILMSLPFALVG--GIWFLYWQ-----GFHMSVATGTgFIALAGVAAEFGVVMLMYLRHAIEAHPELSRKETFTPEG 968
Cdd:TIGR00833  774 LIGSVALSYLWalGLSVLAFQhilgaELHWSVLAGV-FVLLVALGVDYNMLLVSRIKEESPAGNRTGIIRALGSTG 848
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 827-1045 2.11e-08

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 58.31  E-value: 2.11e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   827 DARGRDMVSVVNDIKTAIsEKVKLRPGTSVAFSG----QFELLEHANKKLKLMVPMTVMIIFILLYLAFRRVDEALLILM 902
Cdd:TIGR00921  147 DADYKQVVPIYNDVERSL-ERTNPPSGKFLDVTGspaiNYDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLV 225

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   903 SLPFALVGGIWFLYWQGFHMSVATGTGFIALAGVAAEFGVvmlmylrHAIEAHPELSRKETFTPEGLDEALYHGAVLRVR 982
Cdd:TIGR00921  226 IILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGI-------QTLNRYEEERDIGRAKGEAIVTAVRRTGRAVLI 298

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446496167   983 PKAMTVAVIIAGLLPILwgtgagsEVMSRIAAPMIGGMITAPLLSLFIIPAAYKLI-WLRRHKK 1045
Cdd:TIGR00921  299 ALLTTSAGFAALALSEF-------PMVSEFGLGLVAGLITAYLLTLLVLPALLQSIdIGREKVK 355
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
831-1045 6.27e-08

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 56.79  E-value: 6.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  831 RDMVSVVNDIKTAISEKVKlrPGTSVAFSGQF----ELLEHANKKLKLMVPMTVMIIFILLYLAFRRVDEALLILMSLpf 906
Cdd:COG1033   177 LDRKEVVAEIRAIIAKYED--PGVEVYLTGFPvlrgDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVV-- 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  907 aLVGGIW---FLYWQGFHMSVATGTGFIALAGVAAEFGVVMLMYLRHAIEAHpelsrketftpEGLDEALYHgAVLRV-R 982
Cdd:COG1033   253 -LLAVIWtlgLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYREERRKG-----------LDKREALRE-ALRKLgP 319

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446496167  983 PKAMTVAVIIAGLLPILWgtgAGSEVMSRIAAPMIGGMITAPLLSLFIIPAAykLIWLRRHKK 1045
Cdd:COG1033   320 PVLLTSLTTAIGFLSLLF---SDIPPIRDFGIVAAIGVLLAFLTSLTLLPAL--LSLLPRPKP 377
CusA COG3696
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
152-513 1.20e-07

Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];


Pssm-ID: 442911 [Multi-domain]  Cd Length: 1031  Bit Score: 56.19  E-value: 1.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  152 DLSELRSLQDwflKFE--LKTIPNVAEVA--SVGGVvKQYQIQVNPVKLSQYGISLPEVKQALESSnqeAGGSSV-EMAE 226
Cdd:COG3696   683 DLDVLRRLAE---QIEavLKTVPGAADVQveRVTGL-PQLDIRIDRDAAARYGLNVADVQDVVETA---IGGKAVgQVYE 755

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  227 AEY----MVR-ASGYLQSIDDFNNIVLKTGeNGVPVYLRDVARVQ--TGPEM-------RRGIAELNGQGEVAGGVVilr 292
Cdd:COG3696   756 GERrfdiVVRlPEELRDDPEAIRNLPIPTP-SGAQVPLSQVADIEvvEGPNQisrengrRRIVVQANVRGRDLGSFV--- 831

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  293 sgknaRDVITAVRDKLEtlkasLPEGVEIV--TTYDRSQlidRAIDNLSsklleefIVVAIVCAL-FL---WHVRS---A 363
Cdd:COG3696   832 -----AEAQAKVAEQVK-----LPPGYYIEwgGQFENLQ---RATARLA-------IVVPLALLLiFLllyLAFGSvrdA 891

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  364 LVAIISLPLGLCIAFIVMHFQGLNANI------MSLGGIAiavgamVDAAIVMIENAHKRLEEwdhqhpGEQIDNAtrwk 437
Cdd:COG3696   892 LLILLNVPFALIGGVLALWLRGMPLSVsagvgfIALFGVA------VLNGVVLVSYINQLRAE------GLDLREA---- 955

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  438 vITDASVE-VGPALFISLLIItLSFIPIFTLEG-----QegrlfGPLAFTKTYSMAGAAALAIIVIPILMGFWIRGKIPA 511
Cdd:COG3696   956 -IIEGALErLRPVLMTALVAA-LGLLPMALSTGpgsevQ-----RPLATVVIGGLITSTLLTLLVLPALYLLFGRRRLRR 1028


                  ..
gi 446496167  512 ET 513
Cdd:COG3696  1029 AA 1030
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
827-1048 5.33e-07

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 53.71  E-value: 5.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  827 DARGRDMVSVVNDIKTAISEKVKLrPGTSVAFSGQFELLEHANKKL----KLMVPMTVMIIFILLYLAFRRVDEALLILM 902
Cdd:COG1033   559 DLDSEEIKALVEEVRAFLAENFPP-DGVEVTLTGSAVLFAAINESViesqIRSLLLALLLIFLLLLLAFRSLRLGLISLI 637

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  903 SLPFALVGGIWFLYWQGFHMSVATGTGF-IALaGVAAEFGVVMLMYLRHAIEAHPelsrketftpeGLDEALYHgaVLRV 981
Cdd:COG1033   638 PNLLPILLTFGLMGLLGIPLNIATAVVAsIAL-GIGVDYTIHFLSRYREERRKGG-----------DLEEAIRR--ALRT 703

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446496167  982 RPKAMTV--AVIIAGLLPILWgtgAGSEVMSRIAAPMIGGMITAPLLSLFIIPAAykLIWLRRHKKSVS 1048
Cdd:COG1033   704 TGKAILFtsLTLAAGFGVLLF---SSFPPLADFGLLLALGLLVALLAALLLLPAL--LLLLDPRIAKKR 767
PRK15127 PRK15127
multidrug efflux RND transporter permease subunit AcrB;
6-500 1.09e-04

multidrug efflux RND transporter permease subunit AcrB;


Pssm-ID: 185081 [Multi-domain]  Cd Length: 1049  Bit Score: 46.44  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167    6 IRRSVAnRFLVMMgaLFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQ----IVENQVT-YPLTTTMLSVPGAK 80
Cdd:PRK15127  534 ILRSTG-RYLVLY--LIIVVGMAYLFVRLPSSFLPDEDQGVFLTMVQLPAGATQertqKVLNEVTdYYLTKEKNNVESVF 610

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167   81 TVRGFSQFG----DSYVYVIFEDGTDLYWARSRV-------LEYLNQVQG------KLPAGVssEIGpDATGvgwiFEYA 143
Cdd:PRK15127  611 AVNGFGFAGrgqnTGIAFVSLKDWADRPGEENKVeaitmraTRAFSQIKDamvfafNLPAIV--ELG-TATG----FDFE 683

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  144 LVDRNG-KHD-LSELRSLqdwfLKFELKTIPNVAEVASVGGV--VKQYQIQVNPVKLSQYGISLPEVKQALESSnqeAGG 219
Cdd:PRK15127  684 LIDQAGlGHEkLTQARNQ----LLGEAAKHPDMLVGVRPNGLedTPQFKIDIDQEKAQALGVSISDINTTLGAA---WGG 756

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  220 SSVE------MAEAEYMVRASGYLQSIDDFNNIVLKtGENG--VPVYLRDVARVQTG-PEMRR--GIAELNGQGEVAGGv 288
Cdd:PRK15127  757 SYVNdfidrgRVKKVYVMSEAKYRMLPDDIGDWYVR-AADGqmVPFSAFSSSRWEYGsPRLERynGLPSMEILGQAAPG- 834

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  289 vilRSGKNARDVitavrdkLETLKASLPEGVeivtTYDRSQLI--DRAIDNLSSKLLEEFIVVAIVCALFLWHVRS-ALV 365
Cdd:PRK15127  835 ---KSTGEAMEL-------MEELASKLPTGV----GYDWTGMSyqERLSGNQAPALYAISLIVVFLCLAALYESWSiPFS 900

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  366 AIISLPLGLCIAFIVMHFQGLNANIMSLGGIAIAVGAMVDAAIVMIENAHKRLEEwdhqhPGEQIDNATrwkvITDASVE 445
Cdd:PRK15127  901 VMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDK-----EGKGLIEAT----LEAVRMR 971

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 446496167  446 VGPALFISLLIItLSFIPIFTLEGQEGRLFGPLAFTKTYSMAGAAALAIIVIPIL 500
Cdd:PRK15127  972 LRPILMTSLAFI-LGVMPLVISSGAGSGAQNAVGTGVMGGMVTATVLAIFFVPVF 1025
DUF6404 pfam19942
Family of unknown function (DUF6404); This entry represents a member of a biosynthetic gene ...
 897-950 3.46e-04

Family of unknown function (DUF6404); This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0001055) is described by MIBiG as an example of the following biosynthetic classes, NRP (non-ribosomal peptide) and polyketide, in particular the yersiniabactin biosynthetic gene cluster from Escherichia coli. This family appears to be predominantly found in Proteobacteria.


Pssm-ID: 437774  Cd Length: 115  Bit Score: 41.11  E-value: 3.46e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 446496167   897 ALLILMSLPFALVGGI--WFLYWQGFHMSVATGTGFIALAGVAaeFGVVMLMYLRH 950
Cdd:pfam19942   49 QNFLLFGLFFGVVWGLfmWFLVWQGQGMPPGAAVAASLLAGVL--FGLIMAGYYRW 102
COG4258 COG4258
Predicted exporter [General function prediction only];
836-1036 1.50e-03

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 42.53  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  836 VVNDIKTAISEKVKLRPGTSVAFSGQFELLEHANKKLK----LMVPMTVMIIFILLYLAFRRVDEALLILMSLPFALVGG 911
Cdd:COG4258   211 LVAALRAAFAALNAAFPGAQLLLTGAGLFAVAAAQQIKhdisTIGLISLLGILLLLLLVFRSLRPLLLGLLPVAVGALAG 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496167  912 IWFLYWqGF---H-MSVATGTgfiALAGVAAEFGVVMLMYLRHAIEAHPELSRKETFtpegldealyhgavlrvRPKAMT 987
Cdd:COG4258   291 LAAVSL-VFgsvHgITLGFGS---SLIGVAVDYSLHYLTHRRAAGEWDPRAALRRIW-----------------PTLLLG 349

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 446496167  988 VAVIIAGLLPILWgtgAGSEVMSRIAAPMIGGMITAPLLSLFIIPAAYK 1036
Cdd:COG4258   350 LLTTVLGYLALLF---SPFPGLRQLGVFAAAGLLAAALTTLLWLPLLLP 395
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH