NCBI Conserved Domain Search

Conserved domains on [gi|446496052|ref|WP_000573906|]

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Cu(+)/Ag(+) efflux RND transporter permease subunit CusA [Escherichia coli]

Protein Classification

efflux RND transporter permease subunit( domain architecture ID 1004191)

efflux RND transporter permease subunit such as a CusA/CzcA family heavy metal efflux RND transporter, similar to Escherichia coli cation efflux system protein CusA, which mediates resistance to copper and silver

Gene Ontology: GO:0008324|GO:0005886

TCDB: 2.A.6

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

ACR_tran super family

cl47191

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...

1-1047

0e+00

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.

The actual alignment was detected with superfamily member TIGR00914:

Pssm-ID: 481531 [Multi-domain] Cd Length: 1051 Bit Score: 1670.68 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052     1 MIEWIIRRSVANRFLVLMGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAK 80
Cdd:TIGR00914    1 MIERIISFSVAQRWLVLLATLVMAILGIWSYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052    81 TVRGFSQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAGVSAELGPDATGVGWIYEYALVDRSG-------KHDL 153
Cdd:TIGR00914   81 TTRSLSRYGLSQVTVIFKDGTDLYFARQLVNERLQQARDNLPEGVSPEMGPISTGLGEIFLYTVEAEEGarkkdggAYTL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   154 ADLRSLQDWFLKYELKTIPDVAEVASVGGVVKEYQVVIDPQRLAQYGISLADVKSALDASNQEAGGSSIELAEAEYMVRA 233
Cdd:TIGR00914  161 TDLRTIQDWIIRPQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVRA 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   234 SGYLQTLDDFNHIVLKASEnGVPVYLRDVAKVQVGPEMRRGIAELNGEgEVAGGVVILRSGKNAREVIAAVKDKLETLKS 313
Cdd:TIGR00914  241 PGQVQSMDDIRNIVIATGE-GVPIRIRDVARVQIGKELRTGAATENGK-EVVLGTVFMLIGENSRTVAQAVGDKLETINK 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   314 SLPEGVEIVTTYDRSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSL 393
Cdd:TIGR00914  319 TLPEGVEIVTTYDRSQLVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPLSLLITFIGMVFQGISANLMSL 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   394 GgiAIAVGAMVDAAIVMIENAHKRLEEWLHQHpDATLDNKTRWQVITDASVEVGPALFISLLIITLSFIPIFTLEGQEGR 473
Cdd:TIGR00914  399 G--ALDFGLIVDGAVVIVENAHRRLAEAQHHH-GRQLTLKERLHEVFAASREVRRPLIFGQLIITLVFLPIFTLTGVEGK 475

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   474 LFGPLAFTKTYAMAGAALLAIVVIPILMGYWIRGKIPpESSNPLNRFLIRVYHPLLLKVLHWPKTTLLVAALSVLTVLWP 553
Cdd:TIGR00914  476 MFHPMAFTVVLALAGAMILSLTFVPAAVALFIRGKVA-EKENRLMRVLKRRYEPLLERVLAWPAVVLGAAAVSIVLVVWI 554

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   554 LNKVGGEFLPQINEGDLLYMPSTLPGISAAEAASMLQKTDKLIMSVPEVARVFGKTGKAETATDSAPLEMVETTIQLKPQ 633
Cdd:TIGR00914  555 ASRVGGEFIPSLNEGDLAYQALRIPGTSLAQSVAMQQTLEKLIKSFPEVARVFAKTGTAEIATDPMPPNASDTYIILKPE 634

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   634 DQWRPG--MTMDKIIEELDNTVRLPGLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTVLADIDTMAEQIEEVARTVPGVA 711
Cdd:TIGR00914  635 SQWPEGkkTKEDLIEEIQEATVRIPGNNYEFTQPIQMRFNELISGVRSDVAVKVFGDDLDDLDATAEKISAVLKGVPGAA 714

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   712 SALAERLEGGRYINVEINREKAARYGMTVADVQLFVTSAVGGAMVGETVEGIARYPINLRYPQSWRDSPQALRQLPILTP 791
Cdd:TIGR00914  715 DVKVEQTTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETFEGDRRFDIVIRLPESLRESPQALRQLPIPLP 794

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   792 -----MKQQITLADVADVKVSTGPSMLKTENARPTSWIYIDARDRDMVSVVHDLQKAIAEKVQLKPGTSVAFSGQFELLE 866
Cdd:TIGR00914  795 lsedaRKQFIPLSDVADLRVSPGPNQISRENGKRRVVVSANVRGRDLGSFVDDAKKAIAEQVKLPPGYWITWGGQFEQLQ 874

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   867 RANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIISSVPFALVGGIWLLWWMGFHLSVATGTGFIALAGVAAEFGVVMLM 946
Cdd:TIGR00914  875 SATKRLQIVVPVTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALWLRGIPLSISAAVGFIALSGVAVLNGLVMIS 954

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   947 YLRHAIEAEPSlnnpqtfseqkLDEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPLL 1026
Cdd:TIGR00914  955 FIRKLLEEGPS-----------LDEAVYEGALTRVRPVLMTALVASLGFVPMAIATGTGAEVQRPLATVVIGGIITATLL 1023

                         1050      1060
                   ....*....|....*....|.
gi 446496052  1027 SLFIIPAAYKLMWLHRHRVRK 1047
Cdd:TIGR00914 1024 TLFVLPALYRLVHRRRHKGRK 1044

Name

Accession

Description

Interval

E-value

2A0601

TIGR00914

heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ...

1-1047

0e+00

heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]

Pssm-ID: 129992 [Multi-domain] Cd Length: 1051 Bit Score: 1670.68 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052     1 MIEWIIRRSVANRFLVLMGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAK 80
Cdd:TIGR00914    1 MIERIISFSVAQRWLVLLATLVMAILGIWSYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052    81 TVRGFSQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAGVSAELGPDATGVGWIYEYALVDRSG-------KHDL 153
Cdd:TIGR00914   81 TTRSLSRYGLSQVTVIFKDGTDLYFARQLVNERLQQARDNLPEGVSPEMGPISTGLGEIFLYTVEAEEGarkkdggAYTL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   154 ADLRSLQDWFLKYELKTIPDVAEVASVGGVVKEYQVVIDPQRLAQYGISLADVKSALDASNQEAGGSSIELAEAEYMVRA 233
Cdd:TIGR00914  161 TDLRTIQDWIIRPQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVRA 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   234 SGYLQTLDDFNHIVLKASEnGVPVYLRDVAKVQVGPEMRRGIAELNGEgEVAGGVVILRSGKNAREVIAAVKDKLETLKS 313
Cdd:TIGR00914  241 PGQVQSMDDIRNIVIATGE-GVPIRIRDVARVQIGKELRTGAATENGK-EVVLGTVFMLIGENSRTVAQAVGDKLETINK 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   314 SLPEGVEIVTTYDRSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSL 393
Cdd:TIGR00914  319 TLPEGVEIVTTYDRSQLVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPLSLLITFIGMVFQGISANLMSL 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   394 GgiAIAVGAMVDAAIVMIENAHKRLEEWLHQHpDATLDNKTRWQVITDASVEVGPALFISLLIITLSFIPIFTLEGQEGR 473
Cdd:TIGR00914  399 G--ALDFGLIVDGAVVIVENAHRRLAEAQHHH-GRQLTLKERLHEVFAASREVRRPLIFGQLIITLVFLPIFTLTGVEGK 475

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   474 LFGPLAFTKTYAMAGAALLAIVVIPILMGYWIRGKIPpESSNPLNRFLIRVYHPLLLKVLHWPKTTLLVAALSVLTVLWP 553
Cdd:TIGR00914  476 MFHPMAFTVVLALAGAMILSLTFVPAAVALFIRGKVA-EKENRLMRVLKRRYEPLLERVLAWPAVVLGAAAVSIVLVVWI 554

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   554 LNKVGGEFLPQINEGDLLYMPSTLPGISAAEAASMLQKTDKLIMSVPEVARVFGKTGKAETATDSAPLEMVETTIQLKPQ 633
Cdd:TIGR00914  555 ASRVGGEFIPSLNEGDLAYQALRIPGTSLAQSVAMQQTLEKLIKSFPEVARVFAKTGTAEIATDPMPPNASDTYIILKPE 634

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   634 DQWRPG--MTMDKIIEELDNTVRLPGLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTVLADIDTMAEQIEEVARTVPGVA 711
Cdd:TIGR00914  635 SQWPEGkkTKEDLIEEIQEATVRIPGNNYEFTQPIQMRFNELISGVRSDVAVKVFGDDLDDLDATAEKISAVLKGVPGAA 714

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   712 SALAERLEGGRYINVEINREKAARYGMTVADVQLFVTSAVGGAMVGETVEGIARYPINLRYPQSWRDSPQALRQLPILTP 791
Cdd:TIGR00914  715 DVKVEQTTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETFEGDRRFDIVIRLPESLRESPQALRQLPIPLP 794

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   792 -----MKQQITLADVADVKVSTGPSMLKTENARPTSWIYIDARDRDMVSVVHDLQKAIAEKVQLKPGTSVAFSGQFELLE 866
Cdd:TIGR00914  795 lsedaRKQFIPLSDVADLRVSPGPNQISRENGKRRVVVSANVRGRDLGSFVDDAKKAIAEQVKLPPGYWITWGGQFEQLQ 874

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   867 RANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIISSVPFALVGGIWLLWWMGFHLSVATGTGFIALAGVAAEFGVVMLM 946
Cdd:TIGR00914  875 SATKRLQIVVPVTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALWLRGIPLSISAAVGFIALSGVAVLNGLVMIS 954

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   947 YLRHAIEAEPSlnnpqtfseqkLDEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPLL 1026
Cdd:TIGR00914  955 FIRKLLEEGPS-----------LDEAVYEGALTRVRPVLMTALVASLGFVPMAIATGTGAEVQRPLATVVIGGIITATLL 1023

                         1050      1060
                   ....*....|....*....|.
gi 446496052  1027 SLFIIPAAYKLMWLHRHRVRK 1047
Cdd:TIGR00914 1024 TLFVLPALYRLVHRRRHKGRK 1044

CusA

COG3696

Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];

1-1047

0e+00

Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];

Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 1503.38 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052    1 MIEWIIRRSVANRFLVLMGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAK 80
Cdd:COG3696     1 MLNRIIRFSLRNRLLVLLLTLLLAAAGIYSLRRLPIDAFPDITNVQVQVITEAPGLSPEEVEQQVTYPIETALNGLPGVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   81 TVRGFSQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAGVSAELGPDATGVGWIYEYALVDRSGKHDLADLRSLQ 160
Cdd:COG3696    81 EVRSISRFGLSVVTVIFEDGTDIYWARQLVLERLQQVREQLPAGVTPELGPISTGLGEIYQYTLESDPGKYSLMELRTLQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  161 DWFLKYELKTIPDVAEVASVGGVVKEYQVVIDPQRLAQYGISLADVKSALDASNQEAGGSSIELAEAEYMVRASGYLQTL 240
Cdd:COG3696   161 DWVIRPQLRSVPGVAEVNSFGGFVKQYQVLVDPAKLRAYGLTLDDVIEALERNNANVGGGYIERGGQEYLVRGIGLIRSL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  241 DDFNHIVLKaSENGVPVYLRDVAKVQVGPEMRRGIAELNGEGEVAGGVVILRSGKNAREVIAAVKDKLETLKSSLPEGVE 320
Cdd:COG3696   241 EDIENIVVK-TRNGTPVLLRDVAEVRIGPAPRRGAATLNGEGEVVGGIVLMLKGENALEVIEAVKAKLAELKPSLPEGVK 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  321 IVTTYDRSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIAIAV 400
Cdd:COG3696   320 IVPFYDRSDLIDRAIHTVTKNLLEGALLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLGGLAIDF 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  401 GAMVDAAIVMIENAHKRLEEWLHQHpdatlDNKTRWQVITDASVEVGPALFISLLIITLSFIPIFTLEGQEGRLFGPLAF 480
Cdd:COG3696   400 GIIVDGAVVMVENILRRLEENRAAG-----TPRERLEVVLEAAREVRRPIFFATLIIILVFLPIFTLEGVEGKLFRPMAL 474

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  481 TKTYAMAGAALLAIVVIPILMGYWIRGKIPpESSNPLNRFLIRVYHPLLLKVLHWPKTTLLVAALSVLTVLWPLNKVGGE 560
Cdd:COG3696   475 TVIFALLGALLLSLTLVPVLASLLLRGKVP-EKENPLVRWLKRLYRPLLRWALRHPKLVLAVALVLLVLALALFPRLGSE 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  561 FLPQINEGDLLYMPSTLPGISAAEAASMLQKTDKLIMSVPEVARVFGKTGKAETATDSAPLEMVETTIQLKPQDQWRPGM 640
Cdd:COG3696   554 FLPELDEGDLLVMATLPPGISLEESVELGQQVERILKSFPEVESVVSRTGRAEDATDPMGVNMSETFVILKPRSEWRSGR 633

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  641 TMDKIIEELDNTV-RLPGLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTVLADIDTMAEQIEEVARTVPGVASALAERLE 719
Cdd:COG3696   634 TKEELIAEMREALeQIPGVNFNFSQPIQMRVDELLSGVRADVAVKIFGDDLDVLRRLAEQIEAVLKTVPGAADVQVERVT 713

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  720 GGRYINVEINREKAARYGMTVADVQLFVTSAVGGAMVGETVEGIARYPINLRYPQSWRDSPQALRQLPILTPMKQQITLA 799
Cdd:COG3696   714 GLPQLDIRIDRDAAARYGLNVADVQDVVETAIGGKAVGQVYEGERRFDIVVRLPEELRDDPEAIRNLPIPTPSGAQVPLS 793

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  800 DVADVKVSTGPSMLKTENARPTSWIYIDARDRDMVSVVHDLQKAIAEKVQLKPGTSVAFSGQFELLERANHKLKLMVPMT 879
Cdd:COG3696   794 QVADIEVVEGPNQISRENGRRRIVVQANVRGRDLGSFVAEAQAKVAEQVKLPPGYYIEWGGQFENLQRATARLAIVVPLA 873

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  880 LMIIFVLLYLAFRRVGEALLIISSVPFALVGGIWLLWWMGFHLSVATGTGFIALAGVAAEFGVVMLMYLRHAIEAEPSln 959
Cdd:COG3696   874 LLLIFLLLYLAFGSVRDALLILLNVPFALIGGVLALWLRGMPLSVSAGVGFIALFGVAVLNGVVLVSYINQLRAEGLD-- 951

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  960 npqtfseqkLDEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPLLSLFIIPAAYKlmW 1039
Cdd:COG3696   952 ---------LREAIIEGALERLRPVLMTALVAALGLLPMALSTGPGSEVQRPLATVVIGGLITSTLLTLLVLPALYL--L 1020


                  ....*...
gi 446496052 1040 LHRHRVRK 1047
Cdd:COG3696  1021 FGRRRLRR 1028

ACR_tran

pfam00873

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...

1-1037

0e+00

Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 712.91 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052     1 MIEWIIRRSVAnrflVLMGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAK 80
Cdd:pfam00873    1 MSKFFIRRPIF----TLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052    81 TVRGFSQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAGVS-AELGPDATGVGWIYEYALVDRSGKHDLADLRSL 159
Cdd:pfam00873   77 YMSSQSSYGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGVQrPGISVIKTSLGPIMVLAVTSPDGSYTQTDLRDY 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   160 QDWFLKYELKTIPDVAEVASVGGVVKEYQVVIDPQRLAQYGISLADVKSALDASNQEAGGSSIELAEAEYMVRASGYLQT 239
Cdd:pfam00873  157 ADTNIKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQS 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   240 LDDFNHIVLKaSENGVPVYLRDVAKVQVGPEMRRGIAELNGEgEVAGGVVILRSGKNAREVIAAVKDKLETLKSSLPEGV 319
Cdd:pfam00873  237 AEDFEKIIVK-NQDGSPVRLRDVATVELGSELYRGFATFNGK-PAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQGV 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   320 EIVTTYDRSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIAIA 399
Cdd:pfam00873  315 EIVVVYDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLA 394

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   400 VGAMVDAAIVMIENAHKRLEEwlhqhpdatlDNKTRWQVITDASVEVGPALFISLLIITLSFIPIFTLEGQEGRLFGPLA 479
Cdd:pfam00873  395 IGLVVDDAIVVVENIERVLEE----------NGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFA 464

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   480 FTKTYAMAGAALLAIVVIPILMGYWIRGKIPPE------SSNPLNRFLIRVYHPLLLKVLHWPKTTLLVAALSVLTVLWP 553
Cdd:pfam00873  465 ITIVLAILLSVLVALTLTPALCATLLKPRREPKhggffrWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWL 544

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   554 LNKVGGEFLPQINEGDLLYMPSTLPGISAAEAASMLQKTDKLIMSVPEVARVFGKTGKAEtATDSAPLEMVETTIQLKPQ 633
Cdd:pfam00873  545 FVRIPTEFLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFAF-SGDNNGPNSGDAFISLKPW 623

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   634 DQWR-PGMTMDKIIEELDNTVR-LPGLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTVLADIDTMAEQIEEVARTVPGVA 711
Cdd:pfam00873  624 KERPgPEKSVQALIERLRKALKqIPGANVFLFQPIQLRGLGTISGFRSDLQVKIFGDDLDALDEARNQILAALAQLPGLS 703

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   712 SALAERLEGGRYINVEINREKAARYGMTVADVQLFVTSAVGGAMVGETVEGIARYPINLRYPQSWRDSPQALRQLPILTP 791
Cdd:pfam00873  704 DVRSDGQEDQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYVRNP 783

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   792 MKQQITLADVADVKVSTGPSMLKTENARPTSWIYIDARDRDMVSVVHDLQKAIAEKVQLKPGTSVAFSGQFELLERANHK 871
Cdd:pfam00873  784 YGKMIPLSAFAKIEWGYGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVKLPPGYGYTWTGQFEQEQLAGNS 863

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   872 LKLMVPMTLMIIFVLLYLAFRRVGEALLIISSVPFALVGGIWLLWWMGFHLSVATGTGFIALAGVAAEFGVVMLMYLRHA 951
Cdd:pfam00873  864 LPILIALALLVVFLVLAALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFANEL 943

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   952 IEAEPSlnnpqtfseqKLDEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPLLSLFII 1031
Cdd:pfam00873  944 REQEGK----------SLEEAILEACRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVV 1013


                   ....*.
gi 446496052  1032 PAAYKL 1037
Cdd:pfam00873 1014 PVFYVL 1019

RND_permease_2

NF033617

multidrug efflux RND transporter permease subunit;

4-1037

1.86e-113

multidrug efflux RND transporter permease subunit;

Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 375.12 E-value: 1.86e-113

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052    4 WIIRRSVANrfLVLMGALFLSiwGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAKTVR 83
Cdd:NF033617    3 VFIKRPVAT--LLLSLLILLL--GLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   84 GFSQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAG-----VSAELGPDATGVGWI-YEYALVDRSGKHDLADLR 157
Cdd:NF033617   79 SQSSLGYSTITLQFRLGTDLDVALSEVQAAINAAQSLLPSEapdppVYRKANSADTPIMYIgLTSEEMPRGQLTDYAERV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  158 slqdwfLKYELKTIPDVAEVASVGGVVKEYQVVIDPQRLAQYGISLADVKSALDASNQEAGGSSIELAEAEYMVRASGYL 237
Cdd:NF033617  159 ------LAPKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQL 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  238 QTLDDFNHIVLKASENGVPVYLRDVAKVQVGPEMRRGIAELNGEGEVAGGVVILrSGKNAREVIAAVKDKLETLKSSLPE 317
Cdd:NF033617  233 KTAEDYEDLVIKYADNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQ-PGANPIEVADEIRALLPELQETLPK 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  318 GVEIVTTYDRSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIA 397
Cdd:NF033617  312 NIKVNVLYDRTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALV 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  398 IAVGAMVDAAIVMIENAHKRLEEwlhqhpdatldNKTRWQVITDASVEVGPALfISlLIITLS--FIPIFTLEGQEGRLF 475
Cdd:NF033617  392 LAIGLVVDDAIVVVENIHRHIEE-----------GESPLEAALKGAREIGFTV-IA-MTLTLVavYLPILFMGGLTGRLF 458

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  476 GPLAFTKTYAMAGAALLAIVVIPILMGYWIRGKIPPESSNP-LNRF---LIRVYHPLLLKVLHWPKTTLLVAALSVLTVL 551
Cdd:NF033617  459 REFAVTLAGAVIISGIVALTLTPMMCSRLLKANEKPGRFARaVDRFfdgLTARYGRGLKWVLKHRPLTLVVALATLALLP 538

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  552 WPLNKVGGEFLPQINEGDLLympSTLPGISAAEAASMLQKTDKL---IMSVPEVARVFGKTGKAETATDSAPLEMvettI 628
Cdd:NF033617  539 LLYVFIPKELAPSEDRGVIF---GMIQAPQSISLDYMSAKMRDVekiLSSDPEVQSLTSFNGVGGNPGDNTGFGI----I 611

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  629 QLKPQDQWRpgMTMDKIIEELDNTV-RLPGLA-NLW-VPPIRnridmLSTGIKSPIGIKVSG----TVLADIdtmAEQIE 701
Cdd:NF033617  612 NLKPWDERD--VSAQEIIDRLRPKLaKVPGMDlFLFpLQDLP-----GGAGSSLPQYQVTLTpsdyDSLFTW---AEKLK 681

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  702 EVARTVPGVASALAERLEGGRYINVEINREKAARYGMTVADVQLFVTSAVGGAMVGETVEGIARYPINLRYPQSWRDSPQ 781
Cdd:NF033617  682 EKLRKSPQFADVDSDLQDKGPELNVDIDRDKAARLGISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPE 761

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  782 ALRQLPILTPMKQQITLADVADVKVSTGPSMLKTENARPTSWI-YIDARDRDMVSVVHDLQKAIAEKvqLKPGTSVAFSG 860
Cdd:NF033617  762 ALNQIYVRSNDGKLVPLSTLAKIEERAAPLSLNHFNQFNSATLsFNLAPGVSLGEAIEALDQAAKEL--LPSGISGSFQG 839

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  861 QFELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIISSVPFALVGGIWLLWWMGFHLSVATGTGFIALAGVAAEF 940
Cdd:NF033617  840 AARAFQEEGSSLLFLFLLALAAIYLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKN 919

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  941 GVVMLMYlrhAIEAEpslnnpqtfSEQKLD--EALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIG 1018
Cdd:NF033617  920 GILMVEF---ANELQ---------RHQGLSrrEAIYQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIVG 987

                        1050
                  ....*....|....*....
gi 446496052 1019 GMITAPLLSLFIIPAAYKL 1037
Cdd:NF033617  988 GLGVGTLFTLFVLPVVYLL 1006

PRK09577

multidrug efflux RND transporter permease subunit;

20-1032

9.09e-58

multidrug efflux RND transporter permease subunit;

Pssm-ID: 169981 [Multi-domain] Cd Length: 1032 Bit Score: 216.64 E-value: 9.09e-58

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   20 ALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAKTVRGFSQFGDSYVYVIFED 99
Cdd:PRK09577   16 SLFIMLGGIFAIRALPVAQYPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNGAPGLLYTSATSSAGQASLSLTFKQ 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  100 GTDPYWARSRVLEYLNQVQGKLP-----AGVSAELGPDATGVgwiyEYALVDRSGKHDLADLRSLQDWFLKYELKTIPDV 174
Cdd:PRK09577   96 GVNADLAAVEVQNRLKTVEARLPepvrrDGIQVEKAADNIQL----IVSLTSDDGRLTGVELGEYASANVLQALRRVEGV 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  175 AEVASVGGvvkEYQVVI--DPQRLAQYGISLADVKSALDASNQ-----EAGGSSI-ELAEAEYMVRASGYLQTLDDFNHI 246
Cdd:PRK09577  172 GKVQFWGA---EYAMRIwpDPVKLAALGLTASDIASAVRAHNArvtigDIGRSAVpDSAPIAATVFADAPLKTPEDFGAI 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  247 VLKASENGVPVYLRDVAKVQVGPEMRRGIAELNGEgeVAGGVVI-LRSGKNAREVIAAVKDKLETLKSSLPEGVEIVTTY 325
Cdd:PRK09577  249 ALRARADGSALYLRDVARIEFGGNDYNYPSYVNGK--TATGMGIkLAPGSNAVATEKRVRATMDELSRYFPPGVKYQIPY 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  326 DRSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIAIAVGAMVD 405
Cdd:PRK09577  327 ETSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMQNFRATLIPTLVVPVALLGTFGVMLAAGFSINVLTMFGMVLAIGILVD 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  406 AAIVMIENAHKRL-EEWLHQHpDATLdnktrwqvitDASVEVGPALFISLLIITLSFIPIFTLEGQEGRLFGPLAFTKTY 484
Cdd:PRK09577  407 DAIVVVENVERLMvEEGLSPY-DATV----------KAMKQISGAIVGITVVLTSVFVPMAFFGGAVGNIYRQFALSLAV 475

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  485 AMAGAALLAIVVIPILMGYWIRGKIPPESSNP-----LNRFLIRV---YHPLLLKVLHWPKTTLLVAALSVLTVLWPLNK 556
Cdd:PRK09577  476 SIGFSAFLALSLTPALCATLLKPVDGDHHEKRgffgwFNRFVARStqrYATRVGAILKRPLRWLVVYGALTAAAALLFTR 555

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  557 VGGEFLPQINEGDLLYMPSTLPGISAAEAASMLQKTDKLIMSVPEVARVFGKTGKA--ETATDSApleMVETTIQlkpqd 634
Cdd:PRK09577  556 LPTAFLPDEDQGNFMVMVIRPQGTPLAETMQSVREVESYLRRHEPVAYTFALGGFNlyGEGPNGG---MIFVTLK----- 627

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  635 QWRPGMTMDK----IIEELDntVRLPGLANLWV-----PPIRnriDMLSTG-----IKSPIGIKVSGTVLAdidtmAEQI 700
Cdd:PRK09577  628 DWKERKAARDhvqaIVARIN--ERFAGTPNTTVfamnsPALP---DLGSTSgfdfrLQDRGGLGYAAFVAA-----REQL 697

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  701 EEVARTVPGVASALAERLEGGRYINVEINREKAARYGMTVADVQLFVTSAVGGAMVGETVEGIARYPINLRYPQSWRDSP 780
Cdd:PRK09577  698 LAEGAKDPALTDLMFAGTQDAPQLKLDIDRAKASALGVSMDEINTTLAVMFGSDYIGDFMHGSQVRRVIVQADGRHRLDP 777

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  781 QALRQLPILTPMKQQITLADVADVKVSTGPSMLKTENARPTSWIYIDArdrdmvSVVHDLQKAIAE----KVQLKPGTSV 856
Cdd:PRK09577  778 DDVKKLRVRNAQGEMVPLAAFATLHWTLGPPQLTRYNGYPSFTINGSA------APGHSSGEAMAAieriAATLPAGIGY 851

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  857 AFSGQFELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIISSVPFALVGGIWLLWWMGFHLSVATGTGFIALAGV 936
Cdd:PRK09577  852 AWSGQSFEERLSGAQAPMLFALSVLVVFLALAALYESWSIPFAVMLVVPLGVIGAVLGVTLRGMPNDIYFKVGLIATIGL 931

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  937 AAEFGVVMLMYLRHAIEAEPSLnnpqtfseqkLDEALyHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPM 1016
Cdd:PRK09577  932 SAKNAILIVEVAKDLVAQRMSL----------ADAAL-EAARLRLRPIVMTSLAFGVGVLPLAFASGAASGAQIAIGTGV 1000

                        1050
                  ....*....|....*.
gi 446496052 1017 IGGMITAPLLSLFIIP 1032
Cdd:PRK09577 1001 LGGVITATVLAVFLVP 1016

Name

Accession

Description

Interval

E-value

2A0601

TIGR00914

heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ...

1-1047

0e+00

Pssm-ID: 129992 [Multi-domain] Cd Length: 1051 Bit Score: 1670.68 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052     1 MIEWIIRRSVANRFLVLMGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAK 80
Cdd:TIGR00914    1 MIERIISFSVAQRWLVLLATLVMAILGIWSYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052    81 TVRGFSQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAGVSAELGPDATGVGWIYEYALVDRSG-------KHDL 153
Cdd:TIGR00914   81 TTRSLSRYGLSQVTVIFKDGTDLYFARQLVNERLQQARDNLPEGVSPEMGPISTGLGEIFLYTVEAEEGarkkdggAYTL 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   154 ADLRSLQDWFLKYELKTIPDVAEVASVGGVVKEYQVVIDPQRLAQYGISLADVKSALDASNQEAGGSSIELAEAEYMVRA 233
Cdd:TIGR00914  161 TDLRTIQDWIIRPQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVRA 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   234 SGYLQTLDDFNHIVLKASEnGVPVYLRDVAKVQVGPEMRRGIAELNGEgEVAGGVVILRSGKNAREVIAAVKDKLETLKS 313
Cdd:TIGR00914  241 PGQVQSMDDIRNIVIATGE-GVPIRIRDVARVQIGKELRTGAATENGK-EVVLGTVFMLIGENSRTVAQAVGDKLETINK 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   314 SLPEGVEIVTTYDRSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSL 393
Cdd:TIGR00914  319 TLPEGVEIVTTYDRSQLVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPLSLLITFIGMVFQGISANLMSL 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   394 GgiAIAVGAMVDAAIVMIENAHKRLEEWLHQHpDATLDNKTRWQVITDASVEVGPALFISLLIITLSFIPIFTLEGQEGR 473
Cdd:TIGR00914  399 G--ALDFGLIVDGAVVIVENAHRRLAEAQHHH-GRQLTLKERLHEVFAASREVRRPLIFGQLIITLVFLPIFTLTGVEGK 475

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   474 LFGPLAFTKTYAMAGAALLAIVVIPILMGYWIRGKIPpESSNPLNRFLIRVYHPLLLKVLHWPKTTLLVAALSVLTVLWP 553
Cdd:TIGR00914  476 MFHPMAFTVVLALAGAMILSLTFVPAAVALFIRGKVA-EKENRLMRVLKRRYEPLLERVLAWPAVVLGAAAVSIVLVVWI 554

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   554 LNKVGGEFLPQINEGDLLYMPSTLPGISAAEAASMLQKTDKLIMSVPEVARVFGKTGKAETATDSAPLEMVETTIQLKPQ 633
Cdd:TIGR00914  555 ASRVGGEFIPSLNEGDLAYQALRIPGTSLAQSVAMQQTLEKLIKSFPEVARVFAKTGTAEIATDPMPPNASDTYIILKPE 634

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   634 DQWRPG--MTMDKIIEELDNTVRLPGLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTVLADIDTMAEQIEEVARTVPGVA 711
Cdd:TIGR00914  635 SQWPEGkkTKEDLIEEIQEATVRIPGNNYEFTQPIQMRFNELISGVRSDVAVKVFGDDLDDLDATAEKISAVLKGVPGAA 714

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   712 SALAERLEGGRYINVEINREKAARYGMTVADVQLFVTSAVGGAMVGETVEGIARYPINLRYPQSWRDSPQALRQLPILTP 791
Cdd:TIGR00914  715 DVKVEQTTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETFEGDRRFDIVIRLPESLRESPQALRQLPIPLP 794

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   792 -----MKQQITLADVADVKVSTGPSMLKTENARPTSWIYIDARDRDMVSVVHDLQKAIAEKVQLKPGTSVAFSGQFELLE 866
Cdd:TIGR00914  795 lsedaRKQFIPLSDVADLRVSPGPNQISRENGKRRVVVSANVRGRDLGSFVDDAKKAIAEQVKLPPGYWITWGGQFEQLQ 874

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   867 RANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIISSVPFALVGGIWLLWWMGFHLSVATGTGFIALAGVAAEFGVVMLM 946
Cdd:TIGR00914  875 SATKRLQIVVPVTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALWLRGIPLSISAAVGFIALSGVAVLNGLVMIS 954

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   947 YLRHAIEAEPSlnnpqtfseqkLDEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPLL 1026
Cdd:TIGR00914  955 FIRKLLEEGPS-----------LDEAVYEGALTRVRPVLMTALVASLGFVPMAIATGTGAEVQRPLATVVIGGIITATLL 1023

                         1050      1060
                   ....*....|....*....|.
gi 446496052  1027 SLFIIPAAYKLMWLHRHRVRK 1047
Cdd:TIGR00914 1024 TLFVLPALYRLVHRRRHKGRK 1044

CusA

COG3696

Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];

1-1047

0e+00

Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];

Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 1503.38 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052    1 MIEWIIRRSVANRFLVLMGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAK 80
Cdd:COG3696     1 MLNRIIRFSLRNRLLVLLLTLLLAAAGIYSLRRLPIDAFPDITNVQVQVITEAPGLSPEEVEQQVTYPIETALNGLPGVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   81 TVRGFSQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAGVSAELGPDATGVGWIYEYALVDRSGKHDLADLRSLQ 160
Cdd:COG3696    81 EVRSISRFGLSVVTVIFEDGTDIYWARQLVLERLQQVREQLPAGVTPELGPISTGLGEIYQYTLESDPGKYSLMELRTLQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  161 DWFLKYELKTIPDVAEVASVGGVVKEYQVVIDPQRLAQYGISLADVKSALDASNQEAGGSSIELAEAEYMVRASGYLQTL 240
Cdd:COG3696   161 DWVIRPQLRSVPGVAEVNSFGGFVKQYQVLVDPAKLRAYGLTLDDVIEALERNNANVGGGYIERGGQEYLVRGIGLIRSL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  241 DDFNHIVLKaSENGVPVYLRDVAKVQVGPEMRRGIAELNGEGEVAGGVVILRSGKNAREVIAAVKDKLETLKSSLPEGVE 320
Cdd:COG3696   241 EDIENIVVK-TRNGTPVLLRDVAEVRIGPAPRRGAATLNGEGEVVGGIVLMLKGENALEVIEAVKAKLAELKPSLPEGVK 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  321 IVTTYDRSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIAIAV 400
Cdd:COG3696   320 IVPFYDRSDLIDRAIHTVTKNLLEGALLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLGGLAIDF 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  401 GAMVDAAIVMIENAHKRLEEWLHQHpdatlDNKTRWQVITDASVEVGPALFISLLIITLSFIPIFTLEGQEGRLFGPLAF 480
Cdd:COG3696   400 GIIVDGAVVMVENILRRLEENRAAG-----TPRERLEVVLEAAREVRRPIFFATLIIILVFLPIFTLEGVEGKLFRPMAL 474

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  481 TKTYAMAGAALLAIVVIPILMGYWIRGKIPpESSNPLNRFLIRVYHPLLLKVLHWPKTTLLVAALSVLTVLWPLNKVGGE 560
Cdd:COG3696   475 TVIFALLGALLLSLTLVPVLASLLLRGKVP-EKENPLVRWLKRLYRPLLRWALRHPKLVLAVALVLLVLALALFPRLGSE 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  561 FLPQINEGDLLYMPSTLPGISAAEAASMLQKTDKLIMSVPEVARVFGKTGKAETATDSAPLEMVETTIQLKPQDQWRPGM 640
Cdd:COG3696   554 FLPELDEGDLLVMATLPPGISLEESVELGQQVERILKSFPEVESVVSRTGRAEDATDPMGVNMSETFVILKPRSEWRSGR 633

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  641 TMDKIIEELDNTV-RLPGLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTVLADIDTMAEQIEEVARTVPGVASALAERLE 719
Cdd:COG3696   634 TKEELIAEMREALeQIPGVNFNFSQPIQMRVDELLSGVRADVAVKIFGDDLDVLRRLAEQIEAVLKTVPGAADVQVERVT 713

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  720 GGRYINVEINREKAARYGMTVADVQLFVTSAVGGAMVGETVEGIARYPINLRYPQSWRDSPQALRQLPILTPMKQQITLA 799
Cdd:COG3696   714 GLPQLDIRIDRDAAARYGLNVADVQDVVETAIGGKAVGQVYEGERRFDIVVRLPEELRDDPEAIRNLPIPTPSGAQVPLS 793

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  800 DVADVKVSTGPSMLKTENARPTSWIYIDARDRDMVSVVHDLQKAIAEKVQLKPGTSVAFSGQFELLERANHKLKLMVPMT 879
Cdd:COG3696   794 QVADIEVVEGPNQISRENGRRRIVVQANVRGRDLGSFVAEAQAKVAEQVKLPPGYYIEWGGQFENLQRATARLAIVVPLA 873

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  880 LMIIFVLLYLAFRRVGEALLIISSVPFALVGGIWLLWWMGFHLSVATGTGFIALAGVAAEFGVVMLMYLRHAIEAEPSln 959
Cdd:COG3696   874 LLLIFLLLYLAFGSVRDALLILLNVPFALIGGVLALWLRGMPLSVSAGVGFIALFGVAVLNGVVLVSYINQLRAEGLD-- 951

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  960 npqtfseqkLDEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPLLSLFIIPAAYKlmW 1039
Cdd:COG3696   952 ---------LREAIIEGALERLRPVLMTALVAALGLLPMALSTGPGSEVQRPLATVVIGGLITSTLLTLLVLPALYL--L 1020


                  ....*...
gi 446496052 1040 LHRHRVRK 1047
Cdd:COG3696  1021 FGRRRLRR 1028

ACR_tran

pfam00873

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...

1-1037

0e+00

Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 712.91 E-value: 0e+00

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052     1 MIEWIIRRSVAnrflVLMGALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAK 80
Cdd:pfam00873    1 MSKFFIRRPIF----TLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052    81 TVRGFSQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAGVS-AELGPDATGVGWIYEYALVDRSGKHDLADLRSL 159
Cdd:pfam00873   77 YMSSQSSYGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGVQrPGISVIKTSLGPIMVLAVTSPDGSYTQTDLRDY 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   160 QDWFLKYELKTIPDVAEVASVGGVVKEYQVVIDPQRLAQYGISLADVKSALDASNQEAGGSSIELAEAEYMVRASGYLQT 239
Cdd:pfam00873  157 ADTNIKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQS 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   240 LDDFNHIVLKaSENGVPVYLRDVAKVQVGPEMRRGIAELNGEgEVAGGVVILRSGKNAREVIAAVKDKLETLKSSLPEGV 319
Cdd:pfam00873  237 AEDFEKIIVK-NQDGSPVRLRDVATVELGSELYRGFATFNGK-PAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQGV 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   320 EIVTTYDRSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIAIA 399
Cdd:pfam00873  315 EIVVVYDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLA 394

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   400 VGAMVDAAIVMIENAHKRLEEwlhqhpdatlDNKTRWQVITDASVEVGPALFISLLIITLSFIPIFTLEGQEGRLFGPLA 479
Cdd:pfam00873  395 IGLVVDDAIVVVENIERVLEE----------NGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFA 464

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   480 FTKTYAMAGAALLAIVVIPILMGYWIRGKIPPE------SSNPLNRFLIRVYHPLLLKVLHWPKTTLLVAALSVLTVLWP 553
Cdd:pfam00873  465 ITIVLAILLSVLVALTLTPALCATLLKPRREPKhggffrWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWL 544

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   554 LNKVGGEFLPQINEGDLLYMPSTLPGISAAEAASMLQKTDKLIMSVPEVARVFGKTGKAEtATDSAPLEMVETTIQLKPQ 633
Cdd:pfam00873  545 FVRIPTEFLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFAF-SGDNNGPNSGDAFISLKPW 623

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   634 DQWR-PGMTMDKIIEELDNTVR-LPGLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTVLADIDTMAEQIEEVARTVPGVA 711
Cdd:pfam00873  624 KERPgPEKSVQALIERLRKALKqIPGANVFLFQPIQLRGLGTISGFRSDLQVKIFGDDLDALDEARNQILAALAQLPGLS 703

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   712 SALAERLEGGRYINVEINREKAARYGMTVADVQLFVTSAVGGAMVGETVEGIARYPINLRYPQSWRDSPQALRQLPILTP 791
Cdd:pfam00873  704 DVRSDGQEDQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYVRNP 783

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   792 MKQQITLADVADVKVSTGPSMLKTENARPTSWIYIDARDRDMVSVVHDLQKAIAEKVQLKPGTSVAFSGQFELLERANHK 871
Cdd:pfam00873  784 YGKMIPLSAFAKIEWGYGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVKLPPGYGYTWTGQFEQEQLAGNS 863

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   872 LKLMVPMTLMIIFVLLYLAFRRVGEALLIISSVPFALVGGIWLLWWMGFHLSVATGTGFIALAGVAAEFGVVMLMYLRHA 951
Cdd:pfam00873  864 LPILIALALLVVFLVLAALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFANEL 943

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   952 IEAEPSlnnpqtfseqKLDEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPLLSLFII 1031
Cdd:pfam00873  944 REQEGK----------SLEEAILEACRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVV 1013


                   ....*.
gi 446496052  1032 PAAYKL 1037
Cdd:pfam00873 1014 PVFYVL 1019

AcrB

COG0841

Multidrug efflux pump subunit AcrB [Defense mechanisms];

1-1047

0e+00

Multidrug efflux pump subunit AcrB [Defense mechanisms];

Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 649.47 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052    1 MIEWIIRRSVAnrFLVLMgaLFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAK 80
Cdd:COG0841     3 LSRFFIRRPVA--AIVLS--LLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   81 TVRGFSQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAGVS----AELGPDATGVGWIyeyALvdRSGKHDLADL 156
Cdd:COG0841    79 YITSTSSEGSSSITVEFELGTDIDEALVDVQNAVDRARSDLPEDVEppgvTKVNPSDFPVMVL---AL--SSDDLDELEL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  157 RSLQDWFLKYELKTIPDVAEVASVGGVVKEYQVVIDPQRLAQYGISLADVKSALDASNQEAGGSSIELAEAEYMVRASGY 236
Cdd:COG0841   154 SDYAERNIKDRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGR 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  237 LQTLDDFNHIVLKASeNGVPVYLRDVAKVQVGPEMRRGIAELNGEgEVAGGVVILRSGKNAREVIAAVKDKLETLKSSLP 316
Cdd:COG0841   234 LKTPEEFENIVIRTN-DGSVVRLGDVARVEDGAEDYRSIARLNGK-PAVGLAIQKQPGANALEVADAVRAKLEELQASLP 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  317 EGVEIVTTYDRSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGI 396
Cdd:COG0841   312 EGVELTIVYDQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFAL 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  397 AIAVGAMVDAAIVMIENAHKRLEEwlhqhpdatldNKTRWQVITDASVEVGPALFISLLIITLSFIPIFTLEGQEGRLFG 476
Cdd:COG0841   392 VLAIGIVVDDAIVVVENIERHMEE-----------GLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFR 460

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  477 PLAFTKTYAMAGAALLAIVVIPILMGYWIRGKIPPESSNPLNRF------LIRVYHPLLLKVLHWPKTTLLVAALSVLTV 550
Cdd:COG0841   461 QFALTVAIALLISLFVALTLTPALCARLLKPHPKGKKGRFFRAFnrgfdrLTRGYGRLLRWALRHRKLTLLVALALLALS 540

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  551 LWPLNKVGGEFLPQINEGDLLYMPSTLPGISAAEAASMLQKTDKLIMSVPEVARVFGKTGKAETATDSApleMVETTIQL 630
Cdd:COG0841   541 VLLFGRLPTEFFPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSGGGSGSN---SGTIFVTL 617

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  631 KPQDQwRPgMTMDKIIEEL-DNTVRLPGL-ANLWVPPIRNRidmlstGIKSPIGIKVSGTVLADIDTMAEQIEEVARTVP 708
Cdd:COG0841   618 KPWDE-RD-RSADEIIARLrEKLAKIPGArVFVFQPPAGGL------GSGAPIEVQLQGDDLEELAAAAEKLLAALRQIP 689

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  709 GVASALAERLEGGRYINVEINREKAARYGMTVADVQLFVTSAVGGAMVGETVEGIARYPINLRYPQSWRDSPQALRQLPI 788
Cdd:COG0841   690 GLVDVRSDLQLGKPELQLDIDREKAAALGVTVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLYV 769

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  789 LTPMKQQITLADVADVKVSTGPSMLKTENARPTSWIYID-ARDRDMVSVVHDLQKAIAEkVQLKPGTSVAFSGQFELLER 867
Cdd:COG0841   770 RTPDGEMVPLSSVATIEEGTGPSSINRYNGQRSVTVSANlAPGVSLGEALAAIEELAAE-LKLPPGVSIEFTGQAEEEQE 848

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  868 ANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIISSVPFALVGGIWLLWWMGFHLSVATGTGFIALAGVAAEFGVVMLMY 947
Cdd:COG0841   849 SFSSLGLAFLLALLLVYLVLAAQFESFIQPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDF 928

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  948 LRHAIEAEPSlnnpqtfseqkLDEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPLLS 1027
Cdd:COG0841   929 ANQLREEGMS-----------LREAILEAARLRLRPILMTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLT 997

                        1050      1060
                  ....*....|....*....|
gi 446496052 1028 LFIIPAAYklMWLHRHRVRK 1047
Cdd:COG0841   998 LFVVPVLY--VLLDRLRRRL 1015

RND_permease_2

NF033617

multidrug efflux RND transporter permease subunit;

4-1037

1.86e-113

multidrug efflux RND transporter permease subunit;

Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 375.12 E-value: 1.86e-113

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052    4 WIIRRSVANrfLVLMGALFLSiwGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAKTVR 83
Cdd:NF033617    3 VFIKRPVAT--LLLSLLILLL--GLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   84 GFSQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAG-----VSAELGPDATGVGWI-YEYALVDRSGKHDLADLR 157
Cdd:NF033617   79 SQSSLGYSTITLQFRLGTDLDVALSEVQAAINAAQSLLPSEapdppVYRKANSADTPIMYIgLTSEEMPRGQLTDYAERV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  158 slqdwfLKYELKTIPDVAEVASVGGVVKEYQVVIDPQRLAQYGISLADVKSALDASNQEAGGSSIELAEAEYMVRASGYL 237
Cdd:NF033617  159 ------LAPKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQL 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  238 QTLDDFNHIVLKASENGVPVYLRDVAKVQVGPEMRRGIAELNGEGEVAGGVVILrSGKNAREVIAAVKDKLETLKSSLPE 317
Cdd:NF033617  233 KTAEDYEDLVIKYADNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQ-PGANPIEVADEIRALLPELQETLPK 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  318 GVEIVTTYDRSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIA 397
Cdd:NF033617  312 NIKVNVLYDRTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALV 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  398 IAVGAMVDAAIVMIENAHKRLEEwlhqhpdatldNKTRWQVITDASVEVGPALfISlLIITLS--FIPIFTLEGQEGRLF 475
Cdd:NF033617  392 LAIGLVVDDAIVVVENIHRHIEE-----------GESPLEAALKGAREIGFTV-IA-MTLTLVavYLPILFMGGLTGRLF 458

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  476 GPLAFTKTYAMAGAALLAIVVIPILMGYWIRGKIPPESSNP-LNRF---LIRVYHPLLLKVLHWPKTTLLVAALSVLTVL 551
Cdd:NF033617  459 REFAVTLAGAVIISGIVALTLTPMMCSRLLKANEKPGRFARaVDRFfdgLTARYGRGLKWVLKHRPLTLVVALATLALLP 538

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  552 WPLNKVGGEFLPQINEGDLLympSTLPGISAAEAASMLQKTDKL---IMSVPEVARVFGKTGKAETATDSAPLEMvettI 628
Cdd:NF033617  539 LLYVFIPKELAPSEDRGVIF---GMIQAPQSISLDYMSAKMRDVekiLSSDPEVQSLTSFNGVGGNPGDNTGFGI----I 611

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  629 QLKPQDQWRpgMTMDKIIEELDNTV-RLPGLA-NLW-VPPIRnridmLSTGIKSPIGIKVSG----TVLADIdtmAEQIE 701
Cdd:NF033617  612 NLKPWDERD--VSAQEIIDRLRPKLaKVPGMDlFLFpLQDLP-----GGAGSSLPQYQVTLTpsdyDSLFTW---AEKLK 681

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  702 EVARTVPGVASALAERLEGGRYINVEINREKAARYGMTVADVQLFVTSAVGGAMVGETVEGIARYPINLRYPQSWRDSPQ 781
Cdd:NF033617  682 EKLRKSPQFADVDSDLQDKGPELNVDIDRDKAARLGISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPE 761

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  782 ALRQLPILTPMKQQITLADVADVKVSTGPSMLKTENARPTSWI-YIDARDRDMVSVVHDLQKAIAEKvqLKPGTSVAFSG 860
Cdd:NF033617  762 ALNQIYVRSNDGKLVPLSTLAKIEERAAPLSLNHFNQFNSATLsFNLAPGVSLGEAIEALDQAAKEL--LPSGISGSFQG 839

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  861 QFELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIISSVPFALVGGIWLLWWMGFHLSVATGTGFIALAGVAAEF 940
Cdd:NF033617  840 AARAFQEEGSSLLFLFLLALAAIYLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKN 919

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  941 GVVMLMYlrhAIEAEpslnnpqtfSEQKLD--EALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIG 1018
Cdd:NF033617  920 GILMVEF---ANELQ---------RHQGLSrrEAIYQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIVG 987

                        1050
                  ....*....|....*....
gi 446496052 1019 GMITAPLLSLFIIPAAYKL 1037
Cdd:NF033617  988 GLGVGTLFTLFVLPVVYLL 1006

2A0602

TIGR00915

The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ...

20-1035

3.35e-77

The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]

Pssm-ID: 273335 [Multi-domain] Cd Length: 1044 Bit Score: 274.68 E-value: 3.35e-77

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052    20 ALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAKTVRGFSQF-GDSYVYVIFE 98
Cdd:TIGR00915   16 AIIIMLAGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSSSSDSdGSMTITLTFE 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052    99 DGTDPYWARSRVLEYLNQVQGKLPA-----GVSAElgpdATGVGWIYEYALVDRSGKHDLADLRSLQDWFLKYELKTIPD 173
Cdd:TIGR00915   96 QGTDPDIAQVQVQNKLQLATPLLPQevqrqGVRVE----KASSNFLMVIGLVSDDGSMTKEDLSDYAASNMVDPLSRLEG 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   174 VAEVASVGgvvKEYQVVI--DPQRLAQYGISLADVKSALDASN-QEAGGS-----SIELAEAEYMVRASGYLQTLDDFNH 245
Cdd:TIGR00915  172 VGDVQLFG---SQYAMRIwlDPAKLNSYQLTPADVISAISAQNaQISAGQlgglpAVPGQQLNATIIAQTRLQTPEQFEN 248

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   246 IVLKASENGVPVYLRDVAKVQVGPEMRRGIAELNGEgEVAGGVVILRSGKNAREVIAAVKDKLETLKSSLPEGVEIVTTY 325
Cdd:TIGR00915  249 ILLKVNTDGSQVRLKDVARVELGGENYSISARFNGK-PASGLAIKLATGANALDTAKAVKAELAVLEPFFPQGMKYVYPY 327

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   326 DRSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIAIAVGAMVD 405
Cdd:TIGR00915  328 DTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAMVLAIGLLVD 407

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   406 AAIVMIENAHKRLEEwlhQHPDATLDNKTRWQVITDASVEVGpalfislLIITLSFIPIFTLEGQEGRLFGPLAFTKTYA 485
Cdd:TIGR00915  408 DAIVVVENVERVMAE---EGLPPKEATRKSMGQIQGALVGIA-------MVLSAVFVPMAFFGGSTGAIYRQFSITIVSA 477

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   486 MAGAALLAIVVIPIL---MGYWIRGKIPPES----SNPLNRFLIRV---YHPLLLKVLHWPKTTLLVAALSVLTVLWPLN 555
Cdd:TIGR00915  478 MALSVLVALILTPALcatMLKPIEKGEHHEKkggfFGWFNRMFDSSthgYENGVGKILRRRGRYLLVYVLLVGGMVFLFV 557

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   556 KVGGEFLPQINEGDLLYMPSTLPGISAAEAASMLQKTDKLIMSVP--EVARVFGKTGkAETATDSAPLEMVetTIQLKPQ 633
Cdd:TIGR00915  558 RLPTSFLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKYLLAKEkaNVESVFTVNG-FSFAGRGQNMGMA--FIRLKDW 634

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   634 DQwRPGMTMD--KIIEELD---NTVRLPGLANLWVPPIrnridmLSTGIKSPIGIKVSGTVLADIDTMAE---QIEEVAR 705
Cdd:TIGR00915  635 EE-RTGKENSvfAIAGRATghfMQIKDAMVIAFVPPAI------LELGNATGFDFFLQDRAGLGHEALLQarnQLLGLAA 707

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   706 TVPGVASALAERLEGGRYINVEINREKAARYGMTVADVQLFVTSAVGGAMVGETVEGIARYPINLRYPQSWRDSPQALRQ 785
Cdd:TIGR00915  708 QNPALTRVRPNGLEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVNDFIDRGRVKRVYVQAEEDARMSPEDINK 787

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   786 LPILTPMKQQITLADVADVKVSTGPSMLKTENARPTSWIYIDARDRDMVSVVHDLQKAIAEkvQLKPGTSVAFSGQfELL 865
Cdd:TIGR00915  788 WYVRNASGEMVPFSAFATVRWEYGSPQLERYNGLPSMEILGSAAPGVSTGQAMAAMEAIAQ--KLPPGFGFSWTGM-SYE 864

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   866 ER-ANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIISSVPFALVGGIWLLWWMGFHLSVATGTGFIALAGVAAEFGVVM 944
Cdd:TIGR00915  865 ERlSGSQAPALYALSLLVVFLCLAALYESWSIPVSVMLVVPLGIIGALLATTLRGLSNDVYFQVGLLTTIGLSAKNAILI 944

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   945 LMYLRHAIEAEPSLNnpqtfseqkldEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAP 1024
Cdd:TIGR00915  945 VEFAKELMAQGKSIV-----------EAALEAARLRLRPILMTSLAFILGVVPLAISTGAGSGSQHAIGTGVFGGMVTAT 1013

                         1050
                   ....*....|.
gi 446496052  1025 LLSLFIIPAAY 1035
Cdd:TIGR00915 1014 VLAIFFVPLFY 1024

PRK09577

multidrug efflux RND transporter permease subunit;

20-1032

9.09e-58

multidrug efflux RND transporter permease subunit;

Pssm-ID: 169981 [Multi-domain] Cd Length: 1032 Bit Score: 216.64 E-value: 9.09e-58

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   20 ALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAKTVRGFSQFGDSYVYVIFED 99
Cdd:PRK09577   16 SLFIMLGGIFAIRALPVAQYPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNGAPGLLYTSATSSAGQASLSLTFKQ 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  100 GTDPYWARSRVLEYLNQVQGKLP-----AGVSAELGPDATGVgwiyEYALVDRSGKHDLADLRSLQDWFLKYELKTIPDV 174
Cdd:PRK09577   96 GVNADLAAVEVQNRLKTVEARLPepvrrDGIQVEKAADNIQL----IVSLTSDDGRLTGVELGEYASANVLQALRRVEGV 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  175 AEVASVGGvvkEYQVVI--DPQRLAQYGISLADVKSALDASNQ-----EAGGSSI-ELAEAEYMVRASGYLQTLDDFNHI 246
Cdd:PRK09577  172 GKVQFWGA---EYAMRIwpDPVKLAALGLTASDIASAVRAHNArvtigDIGRSAVpDSAPIAATVFADAPLKTPEDFGAI 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  247 VLKASENGVPVYLRDVAKVQVGPEMRRGIAELNGEgeVAGGVVI-LRSGKNAREVIAAVKDKLETLKSSLPEGVEIVTTY 325
Cdd:PRK09577  249 ALRARADGSALYLRDVARIEFGGNDYNYPSYVNGK--TATGMGIkLAPGSNAVATEKRVRATMDELSRYFPPGVKYQIPY 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  326 DRSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIAIAVGAMVD 405
Cdd:PRK09577  327 ETSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMQNFRATLIPTLVVPVALLGTFGVMLAAGFSINVLTMFGMVLAIGILVD 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  406 AAIVMIENAHKRL-EEWLHQHpDATLdnktrwqvitDASVEVGPALFISLLIITLSFIPIFTLEGQEGRLFGPLAFTKTY 484
Cdd:PRK09577  407 DAIVVVENVERLMvEEGLSPY-DATV----------KAMKQISGAIVGITVVLTSVFVPMAFFGGAVGNIYRQFALSLAV 475

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  485 AMAGAALLAIVVIPILMGYWIRGKIPPESSNP-----LNRFLIRV---YHPLLLKVLHWPKTTLLVAALSVLTVLWPLNK 556
Cdd:PRK09577  476 SIGFSAFLALSLTPALCATLLKPVDGDHHEKRgffgwFNRFVARStqrYATRVGAILKRPLRWLVVYGALTAAAALLFTR 555

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  557 VGGEFLPQINEGDLLYMPSTLPGISAAEAASMLQKTDKLIMSVPEVARVFGKTGKA--ETATDSApleMVETTIQlkpqd 634
Cdd:PRK09577  556 LPTAFLPDEDQGNFMVMVIRPQGTPLAETMQSVREVESYLRRHEPVAYTFALGGFNlyGEGPNGG---MIFVTLK----- 627

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  635 QWRPGMTMDK----IIEELDntVRLPGLANLWV-----PPIRnriDMLSTG-----IKSPIGIKVSGTVLAdidtmAEQI 700
Cdd:PRK09577  628 DWKERKAARDhvqaIVARIN--ERFAGTPNTTVfamnsPALP---DLGSTSgfdfrLQDRGGLGYAAFVAA-----REQL 697

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  701 EEVARTVPGVASALAERLEGGRYINVEINREKAARYGMTVADVQLFVTSAVGGAMVGETVEGIARYPINLRYPQSWRDSP 780
Cdd:PRK09577  698 LAEGAKDPALTDLMFAGTQDAPQLKLDIDRAKASALGVSMDEINTTLAVMFGSDYIGDFMHGSQVRRVIVQADGRHRLDP 777

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  781 QALRQLPILTPMKQQITLADVADVKVSTGPSMLKTENARPTSWIYIDArdrdmvSVVHDLQKAIAE----KVQLKPGTSV 856
Cdd:PRK09577  778 DDVKKLRVRNAQGEMVPLAAFATLHWTLGPPQLTRYNGYPSFTINGSA------APGHSSGEAMAAieriAATLPAGIGY 851

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  857 AFSGQFELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIISSVPFALVGGIWLLWWMGFHLSVATGTGFIALAGV 936
Cdd:PRK09577  852 AWSGQSFEERLSGAQAPMLFALSVLVVFLALAALYESWSIPFAVMLVVPLGVIGAVLGVTLRGMPNDIYFKVGLIATIGL 931

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  937 AAEFGVVMLMYLRHAIEAEPSLnnpqtfseqkLDEALyHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPM 1016
Cdd:PRK09577  932 SAKNAILIVEVAKDLVAQRMSL----------ADAAL-EAARLRLRPIVMTSLAFGVGVLPLAFASGAASGAQIAIGTGV 1000

                        1050
                  ....*....|....*.
gi 446496052 1017 IGGMITAPLLSLFIIP 1032
Cdd:PRK09577 1001 LGGVITATVLAVFLVP 1016

PRK09579

multidrug efflux RND transporter permease subunit;

6-1038

3.32e-56

multidrug efflux RND transporter permease subunit;

Pssm-ID: 169983 [Multi-domain] Cd Length: 1017 Bit Score: 212.00 E-value: 3.32e-56

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052    6 IRR----SVANRFLVLMGalflsiWGTWTIIntPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAKT 81
Cdd:PRK09579    8 IRRpvlaSVVSLLIVLLG------FQAWSKL--QIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   82 VRGFSQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAG----VSAELGPDATGVGWIYEYAlvDRSGKHDLADLR 157
Cdd:PRK09579   80 MTSVSRQNFSIISIYARIGADSDRLFTELLAKANEVKNQLPQDaedpVLSKEAADASALMYISFYS--EEMSNPQITDYL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  158 SLqdwFLKYELKTIPDVAEVASVGGVVKEYQVVIDPQRLAQYGISLADVKSALDASNQEAGGSSIElaeAEYMV---RAS 234
Cdd:PRK09579  158 SR---VIQPKLATLPGMAEAEILGNQVFAMRLWLDPVKLAGFGLSAGDVTQAVRRYNFLSAAGEVK---GEYVVtsiNAS 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  235 GYLQTLDDFNHIVLKASENGvPVYLRDVAKVQVGPEMRRGIAELNGEGEVAGGVVILRSGkNAREVIAAVKDKLETLKSS 314
Cdd:PRK09579  232 TELKSAEAFAAIPVKTSGDS-RVLLGDVARVEMGAENYDSISSFDGIPSVYIGIKATPSA-NPLDVIKEVRAIMPELESQ 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  315 LPEGVEIVTTYDRSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLG 394
Cdd:PRK09579  310 LPPNLKVSIAYDATLFIQASIDEVVKTLGEAVLIVIVVVFLFLGALRSVLIPVVTIPLSMIGVLFFMQMMGYSINLLTLL 389

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  395 GIAIAVGAMVDAAIVMIENAHKRLEEwlhqhpdatldNKTRWQVITDASVEVgpALFISLLIITLS--FIPIFTLEGQEG 472
Cdd:PRK09579  390 AMVLAIGLVVDDAIVVVENIHRHIEE-----------GKSPFDAALEGAREI--AMPVVSMTITLAavYAPIGFLTGLTG 456

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  473 RLFGPLAFTKTYAMAGAALLAIVVIPILMGYWIRGKIPPES-SNPLNRF---LIRVYHPLLLKVLHwPKTTLLVAALSVL 548
Cdd:PRK09579  457 ALFKEFALTLAGAVIISGIVALTLSPMMCALLLRHEENPSGlAHRLDRLferLKQRYQRALHGTLN-TRPVVLVFAVIVL 535

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  549 TVLWPLNK-VGGEFLPQINEGDLLYMPSTLPGISAAEAASMLQKTDKLIMSVPEVARVFGKTGkaetatdsapLEMVETT 627
Cdd:PRK09579  536 ALIPVLLKfTQSELAPEEDQGIIFMMSSSPQPANLDYLNAYTDEFTPIFKSFPEYYSSFQING----------FNGVQSG 605

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  628 IQ---LKPQDQwRPGMTMDKIIEELDNTVRLPGLANLWVppirNRIDMLSTGIKSPIGIKVSGTvlADIDTMAEqieeva 704
Cdd:PRK09579  606 IGgflLKPWNE-RERTQMELLPLVQAKLEEIPGLQIFGF----NLPSLPGTGEGLPFQFVINTA--NDYESLLQ------ 672

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  705 rtvpgVASALAER-LEGGRY-------------INVEINREKAARYGMTVADVQLFVTSAVGGAMVGE-TVEGIArYPIN 769
Cdd:PRK09579  673 -----VAQRVKQRaQESGKFafldidlafdkpeVVVDIDRAKAAQMGVSMQDLGGTLATLLGEGEINRfTIDGRS-YKVI 746

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  770 LRYPQSWRDSPQALRQLPILTPMKQQITLADVADVKVSTGPSMLKTENARPTSWIyidaRDRDMVSVVHDLQ--KAIAEK 847
Cdd:PRK09579  747 AQVERPYRDNPGWLNNYYVKNEQGQLLPLSTLITLSDRARPRQLNQFQQLNSAII----SGFPIVSMGEAIEtvQQIARE 822

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  848 vQLKPGTSVAFSGQFELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIISSVPFALVGGIWLLWWMGFHLSVATG 927
Cdd:PRK09579  823 -EAPEGFAFDYAGASRQYVQEGSALWVTFGLALAIIFLVLAAQFESFRDPLVILVTVPLSICGALIPLFLGVSSMNIYTQ 901

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  928 TGFIALAGVAAEFGVVMlmylrhaIEAEPSLNNPQTFSEQkldEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSE 1007
Cdd:PRK09579  902 VGLVTLIGLISKHGILI-------VEFANQLRHEQGLSRR---EAIEEAAAIRLRPVLMTTAAMVFGMVPLILATGAGAV 971

                        1050      1060      1070
                  ....*....|....*....|....*....|.
gi 446496052 1008 VMSRIAAPMIGGMITAPLLSLFIIPAAYKLM 1038
Cdd:PRK09579  972 SRFDIGLVIATGMSIGTLFTLFVLPCIYTLL 1002

PRK15127

multidrug efflux RND transporter permease subunit AcrB;

20-1032

5.83e-56

multidrug efflux RND transporter permease subunit AcrB;

Pssm-ID: 185081 [Multi-domain] Cd Length: 1049 Bit Score: 211.30 E-value: 5.83e-56

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   20 ALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAKTVRGFS-QFGDSYVYVIFE 98
Cdd:PRK15127   16 AIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSdSTGTVQITLTFE 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   99 DGTDPYWARSRVLEYLNQVQGKLPAGVSAE-LGPDATGVGWIYEYALVDRSGKHDLADLRSLQDWFLKYELKTIPDVAEV 177
Cdd:PRK15127   96 SGTDADIAQVQVQNKLQLAMPLLPQEVQQQgVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDPISRTSGVGDV 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  178 ASVGGvvkEYQVVI--DPQRLAQYGISLADVKSALDASN------QEAGGSSIELAEAEYMVRASGYLQTLDDFNHIVLK 249
Cdd:PRK15127  176 QLFGS---QYAMRIwmNPNELNKFQLTPVDVINAIKAQNaqvaagQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKILLK 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  250 ASENGVPVYLRDVAKVQVGPEMRRGIAELNGEgEVAGGVVILRSGKNAREVIAAVKDKLETLKSSLPEGVEIVTTYDRSQ 329
Cdd:PRK15127  253 VNQDGSRVRLRDVAKIELGGENYDIIAEFNGQ-PASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTTP 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  330 LIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIAIAVGAMVDAAIV 409
Cdd:PRK15127  332 FVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIV 411

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  410 MIENAHKRL-EEWLhqhPDATLDNKTRWQVitdASVEVGPALFISLLiitlsFIPIFTLEGQEGRLFGPLAFTKTYAMAG 488
Cdd:PRK15127  412 VVENVERVMaEEGL---PPKEATRKSMGQI---QGALVGIAMVLSAV-----FVPMAFFGGSTGAIYRQFSITIVSAMAL 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  489 AALLAIVVIPILMGYWIR-------GKIPPESSNPLNRFLIRVYHPLLLKVLHWPKTT---LLVAALSVLTVLWPLNKVG 558
Cdd:PRK15127  481 SVLVALILTPALCATMLKpiakgdhGEGKKGFFGWFNRMFEKSTHHYTDSVGNILRSTgryLVLYLIIVVGMAYLFVRLP 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  559 GEFLPQINEGDLLYMPSTLPGISAAEAASML-QKTDKLIM----SVPEVARV--FGKTGKAETATDSaplemvetTIQLK 631
Cdd:PRK15127  561 SSFLPDEDQGVFLTMVQLPAGATQERTQKVLnEVTDYYLTkeknNVESVFAVngFGFAGRGQNTGIA--------FVSLK 632

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  632 PQDQwRPGMTMdkiieeldntvRLPGLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTVLADIDTM------AEQIEEVAR 705
Cdd:PRK15127  633 DWAD-RPGEEN-----------KVEAITMRATRAFSQIKDAMVFAFNLPAIVELGTATGFDFELIdqaglgHEKLTQARN 700

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  706 TVPGVASALAERLEGGR--------YINVEINREKAARYGMTVADVQLFVTSAVGGAMVGETVEgiaRYPINLRYPQS-- 775
Cdd:PRK15127  701 QLLGEAAKHPDMLVGVRpngledtpQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFID---RGRVKKVYVMSea 777

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  776 -WRDSPQALRQLPILTPMKQQITLADVADVKVSTGPSMLKTENARPTSWIYIDARDRDMVSVVHDLQKAIAEKvqLKPGT 854
Cdd:PRK15127  778 kYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEELASK--LPTGV 855

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  855 SVAFSGQFELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIISSVPFALVGGIWLLWWMGFHLSVATGTGFIALA 934
Cdd:PRK15127  856 GYDWTGMSYQERLSGNQAPALYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTI 935

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  935 GVAAEFGVVMLMYLRHAIEAEpslnnpqtfsEQKLDEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAA 1014
Cdd:PRK15127  936 GLSAKNAILIVEFAKDLMDKE----------GKGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGT 1005

                        1050
                  ....*....|....*...
gi 446496052 1015 PMIGGMITAPLLSLFIIP 1032
Cdd:PRK15127 1006 GVMGGMVTATVLAIFFVP 1023

PRK10555

multidrug efflux RND transporter permease AcrD;

20-1032

7.35e-54

multidrug efflux RND transporter permease AcrD;

Pssm-ID: 182544 [Multi-domain] Cd Length: 1037 Bit Score: 204.68 E-value: 7.35e-54

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   20 ALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAKTVRG-FSQFGDSYVYVIFE 98
Cdd:PRK10555   16 AILLCLTGTLAIFSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSqSSGTGQASVTLSFK 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   99 DGTDPYWARSRVLEYLNQVQGKLPAGVSAE-LGPDATGVGWIYEYALVDRSG---KHDLADL--RSLQDwflkyELKTIP 172
Cdd:PRK10555   96 AGTDPDEAVQQVQNQLQSAMRKLPQAVQNQgVTVRKTGDTNILTIAFVSTDGsmdKQDIADYvaSNIQD-----PLSRVN 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  173 DVAEVASVGgvvKEYQVVI--DPQRLAQYGISLADVKSALDASN------QEAGGSSIELAEAEYMVRASGYLQTLDDFN 244
Cdd:PRK10555  171 GVGDIDAYG---SQYSMRIwlDPAKLNSFQMTTKDVTDAIESQNaqiavgQLGGTPSVDKQALNATINAQSLLQTPEQFR 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  245 HIVLKASENGVPVYLRDVAKVQVGPEMRRGIAELNGEgEVAGGVVILRSGKNAREVIAAVKDKLETLKSSLPEGVEIVTT 324
Cdd:PRK10555  248 DITLRVNQDGSEVTLGDVATVELGAEKYDYLSRFNGK-PASGLGVKLASGANEMATAKLVLNRLDELAQYFPHGLEYKVA 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  325 YDRSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIAIAVGAMV 404
Cdd:PRK10555  327 YETTSFVKASIEDVVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGYSINTLTMFAMVLAIGLLV 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  405 DAAIVMIENAHKRLEEWLHQHPDATldNKTRWQVitdASVEVGPALFISLLiitlsFIPIFTLEGQEGRLFGPLAFTKTY 484
Cdd:PRK10555  407 DDAIVVVENVERIMSEEGLTPREAT--RKSMGQI---QGALVGIAMVLSAV-----FVPMAFFGGTTGAIYRQFSITIVS 476

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  485 AMAGAALLAIVVIPILMGYWIRGKIPPESSNP------LNRFLIRV---YHPLLLKVLHWPKTTLLVAALSVLTVLWPLN 555
Cdd:PRK10555  477 AMVLSVLVAMILTPALCATLLKPLKKGEHHGQkgffgwFNRMFNRNaerYEKGVAKILHRSLRWILIYVLLLGGMVFLFL 556

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  556 KVGGEFLPQINEGDLLYMPSTLPGISAAEAASMLQKTDK--LIMSVPEVARVFGKTGKAETATDSAPLEMVettIQLKPQ 633
Cdd:PRK10555  557 RLPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVEKVEKyyFTHEKDNVMSVFATVGSGPGGNGQNVARMF---IRLKDW 633

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  634 DQwRPGM--TMDKIIEELDNTVRLPGLANLWV--PPIrnridmlSTGIKSPIGIKV-----SGTVLADIDTMAEQIEEVA 704
Cdd:PRK10555  634 DE-RDSKtgTSFAIIERATKAFNKIKEARVIAssPPA-------ISGLGSSAGFDMelqdhAGAGHDALMAARNQLLALA 705

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  705 RTVPGVASALAERLEGGRYINVEINREKAARYGMTVADVQLFVTSAVGGAMVGETVEgiaRYPINLRYPQS---WRDSPQ 781
Cdd:PRK10555  706 AKNPELTRVRHNGLDDSPQLQIDIDQRKAQALGVSIDDINDTLQTAWGSSYVNDFMD---RGRVKKVYVQAaapYRMLPD 782

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  782 ALRQLPILTPMKQQITLADVADVKVSTGPSMLKTENARPTSWIYIDARDRDMVSVVHDLQKAIAEkvQLKPGTSVAFSGQ 861
Cdd:PRK10555  783 DINLWYVRNKDGGMVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGVSTGTAMDIMESLVK--QLPNGFGLEWTAM 860

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  862 fELLER-ANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIISSVPFALVGGIWLLWWMGFHLSVATGTGFIALAGVAAEF 940
Cdd:PRK10555  861 -SYQERlSGAQAPALYAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKN 939

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  941 GVVMlmylrhaIEAEPSLNNpqtfSEQKLDEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGM 1020
Cdd:PRK10555  940 AILI-------VEFANEMNQ----KGHDLFEATLHASRQRLRPILMTSLAFIFGVLPMATSTGAGSGSQHAVGTGVMGGM 1008

                        1050
                  ....*....|..
gi 446496052 1021 ITAPLLSLFIIP 1032
Cdd:PRK10555 1009 ISATILAIFFVP 1020

PRK10614

multidrug efflux system subunit MdtC; Provisional

6-1047

7.49e-52

multidrug efflux system subunit MdtC; Provisional

Pssm-ID: 182589 [Multi-domain] Cd Length: 1025 Bit Score: 198.41 E-value: 7.49e-52

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052    6 IRRSVANRFLvlmgALFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQIVENQVTYPLTTTMLSVPGAKTVRGF 85
Cdd:PRK10614    8 IYRPVATILL----SLAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   86 SQFGDSYVYVIFEDGTDPYWARSRVLEYLNQVQGKLPAGVSAE-----------------LGPDATGVGWIYEYAlvdrs 148
Cdd:PRK10614   84 SSLGSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRptyrkanpsdapimiltLTSDTYSQGQLYDFA----- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  149 gkhdladlrSLQdwfLKYELKTIPDVAEVASVGGVVKEYQVVIDPQRLAQYGISLADVKSALDASNQEAGGSSIELAEAE 228
Cdd:PRK10614  159 ---------STQ---LAQTISQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRQAISNANVRRPQGAVEDGTHR 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  229 YMVRASGYLQTLDDFNHIVLKASeNGVPVYLRDVAKVQVGPEMRRGIAELNGEGEVAggVVILRS-GKNAREVIAAVKDK 307
Cdd:PRK10614  227 WQIQTNDELKTAAEYQPLIIHYN-NGAAVRLGDVATVTDSVQDVRNAGMTNAKPAIL--LMIRKLpEANIIQTVDRIRAK 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  308 LETLKSSLPEGVEIVTTYDRSQLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLN 387
Cdd:PRK10614  304 LPELRETIPAAIDLQIAQDRSPTIRASLEEVEQTLAISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFS 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  388 ANIMSLGGIAIAVGAMVDAAIVMIENAHKRLEEWLHQhpdatldnktrWQVITDASVEVG-PALFISLLIITLsFIPIFT 466
Cdd:PRK10614  384 LNNLSLMALTIATGFVVDDAIVVLENISRHLEAGMKP-----------LQAALQGVREVGfTVLSMSLSLVAV-FLPLLL 451

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  467 LEGQEGRLFGPLAFTKTYAMAGAALLAIVVIPILMGYWIRGKIPPESSNP--LNRFLIRV---YHPLLLKVLHWPKTTLL 541
Cdd:PRK10614  452 MGGLPGRLFREFAVTLSVAIGISLLVSLTLTPMMCAWLLKSSKPREQKRLrgFGRMLVALqqgYGRSLKWVLNHTRWVGV 531

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  542 VAALSVLTVLWPLNKVGGEFLPQINEGDLLYMPSTLPGISAAEAASMLQKTDKLIMSVPEVARVFGKTGKAETATDSapl 621
Cdd:PRK10614  532 VLLGTIALNVWLYISIPKTFFPEQDTGRLMGFIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTGGSRVNSGM--- 608

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  622 emveTTIQLKPQDQwrPGMTMDKIIEELDNTV-RLPGlANLWVPPIRnriDMLSTGIKSPIGIKVS--GTVLADIDTMAE 698
Cdd:PRK10614  609 ----MFITLKPLSE--RSETAQQVIDRLRVKLaKEPG-ANLFLMAVQ---DIRVGGRQSNASYQYTllSDDLAALREWEP 678

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  699 QIEEVARTVPGVASALAERLEGGRYINVEINREKAARYGMTVADVQLFVTSAVGGAMVGETVEGIARYPINLRYPQSWRD 778
Cdd:PRK10614  679 KIRKALAALPELADVNSDQQDKGAEMALTYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPLNQYKVVMEVDPRYTQ 758

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  779 SPQALRQLPILTPMKQQITLADVADVKVSTGPSMLKTENARPTSWIYIDARDRDMVSvvhDLQKAIAEKV-QLKPGTSV- 856
Cdd:PRK10614  759 DISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSAASTISFNLPTGKSLS---DASAAIERAMtQLGVPSTVr 835

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  857 -AFSGQFELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIISSVPFALVGGIWLLWWMGFHLSVatgtgfIALAG 935
Cdd:PRK10614  836 gSFAGTAQVFQETMNSQLILILAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSL------IALIG 909

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  936 VAAEFGVV---MLMYLRHAIEAEPSLN-NPQtfseqkldEALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSR 1011
Cdd:PRK10614  910 IMLLIGIVkknAIMMVDFALEAQRNGNlTAQ--------EAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGAELRQP 981

                        1050      1060      1070
                  ....*....|....*....|....*....|....*.
gi 446496052 1012 IAAPMIGGMITAPLLSLFIIPAAYKLMWLHRHRVRK 1047
Cdd:PRK10614  982 LGITIVGGLVMSQLLTLYTTPVVYLFFDRLRLRFSR 1017

PRK10503

MdtB/MuxB family multidrug efflux RND transporter permease subunit;

35-1047

1.89e-49

MdtB/MuxB family multidrug efflux RND transporter permease subunit;

Pssm-ID: 182501 [Multi-domain] Cd Length: 1040 Bit Score: 190.71 E-value: 1.89e-49

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   35 PVDALP--DLSDVQVIikTSYPGQAPQIVENQVTYPLTTTMLSVPGAKTVRGFSQFGDSYVYVIFEDGTDPYWARSRVLE 112
Cdd:PRK10503   42 PVSALPevDYPTIQVV--TLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQA 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  113 YLNQVQGKLPAG-----VSAELGP-DATGVGWIYEYALVDRSGKHDLADLRSLQdwflkyELKTIPDVAEVASVGGVVKE 186
Cdd:PRK10503  120 AINAATNLLPSDlpnppVYSKVNPaDPPIMTLAVTSTAMPMTQVEDMVETRVAQ------KISQVSGVGLVTLSGGQRPA 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  187 YQVVIDPQRLAQYGISLADVKSALDASNQEAGGSSIELAEAEYMVRASGYLQTLDDFNHIVLkASENGVPVYLRDVAKVQ 266
Cdd:PRK10503  194 VRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPTRAVTLSANDQMQSAEEYRQLII-AYQNGAPIRLGDVATVE 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  267 VGPEMRRGIAELNGEGEVAGGVViLRSGKNAREVIAAVKDKLETLKSSLPEGVEIVTTYDRSQLIDRAIDNLSGKLLEEF 346
Cdd:PRK10503  273 QGAENSWLGAWANKQQAIVMNVQ-RQPGANIIATADSIRQMLPQLTESLPKSVKVTVLSDRTTNIRASVDDTQFELMLAI 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  347 IVVAVVCALFLWHVRSALVAIISLPLGLCIAFIVMHFQGLNANIMSLGGIAIAVGAMVDAAIVMIENAHKRLEEwlHQHP 426
Cdd:PRK10503  352 ALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEK--GEKP 429

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  427 -DATLDNktrwqvitdasvevgpALFISLLIITLSF------IPIFTLEGQEGRLFGPLAFTKTYAMAGAALLAIVVIPI 499
Cdd:PRK10503  430 lAAALKG----------------AGEIGFTIISLTFsliavlIPLLFMGDIVGRLFREFAVTLAVAILISAVVSLTLTPM 493

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  500 LMGYWIRgkipPESSNPLNRF----------LIRVYHPLLLKVLHWPKTTLLVA----ALSVLtvLWPLNKVGgeFLPQI 565
Cdd:PRK10503  494 MCARMLS----QESLRKQNRFsrasermfdrVIAAYGRGLAKVLNHPWLTLSVAlstlLLTVL--LWIFIPKG--FFPVQ 565

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  566 NEGDL---LYMPSTlpgISAAEAASMLQKTDKLIMSVPEVARV--FGKTGKAETATDSAPLEmvettIQLKPQDQWRPgm 640
Cdd:PRK10503  566 DNGIIqgtLQAPQS---SSFANMAQRQRQVADVILQDPAVQSLtsFVGVDGTNPSLNSARLQ-----INLKPLDERDD-- 635

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  641 TMDKIIEELDNTV-RLPGlANLWVPPIRN-RIDMLSTgiKSPIGIKVSGTVLADIDTMAEQIEEVARTVPGVASALAERL 718
Cdd:PRK10503  636 RVQKVIARLQTAVaKVPG-VDLYLQPTQDlTIDTQVS--RTQYQFTLQATSLDALSTWVPKLMEKLQQLPQLSDVSSDWQ 712

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  719 EGGRYINVEINREKAARYGMTVADVQLFVTSAVGGAMVGETVEGIARYPINLRYPQSWRDSPQALRQLPILTPMKQQITL 798
Cdd:PRK10503  713 DKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPL 792

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  799 ADVADVKVSTGPSMLKTENARPTSWIYIDARD----RDMVSVVHDLQKAIAEKVQLKP---GTSVAFSGQFelleraNHK 871
Cdd:PRK10503  793 SSIATIEQRFGPLSINHLDQFPSTTISFNVPDgyslGDAVQAIMDTEKTLNLPADITTqfqGSTLAFQSAL------GST 866

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  872 LKLMVPMTLMIIFVL--LYLAFRrvgEALLIISSVPFALVGGIWLLWWMGFHLSVATGTGFIALAGVAAEFGVVMLMYlr 949
Cdd:PRK10503  867 VWLIVAAVVAMYIVLgvLYESFI---HPITILSTLPTAGVGALLALMIAGSELDVIAIIGIILLIGIVKKNAIMMIDF-- 941

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  950 hAIEAEpslnnpqtfSEQKLD--EALYHGAVLRVRPKAMTVAVIIAGLLPILWGTGAGSEVMSRIAAPMIGGMITAPLLS 1027
Cdd:PRK10503  942 -ALAAE---------REQGMSprDAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGICMVGGLIVSQVLT 1011

                        1050      1060
                  ....*....|....*....|
gi 446496052 1028 LFIIPAAYKLMWLHRHRVRK 1047
Cdd:PRK10503 1012 LFTTPVIYLLFDRLALYTKS 1031

MMPL

COG1033

Predicted exporter protein, RND superfamily [General function prediction only];

293-513

1.27e-09

Predicted exporter protein, RND superfamily [General function prediction only];

Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 62.18 E-value: 1.27e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  293 SGKNAREVIAAVKDKLETLKSslPEGVEI------VTTYDrsqLIDRAIDNLSGKLLEEFIVVAVVCALFLWHVRSALVA 366
Cdd:COG1033   561 DSEEIKALVEEVRAFLAENFP--PDGVEVtltgsaVLFAA---INESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLIS 635

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  367 IISLPLGLCIAFIVMHFQGLNANIMSLGGIAIAVGAMVDAAIVMIenaHKRLEEWLHqhpdatldNKTRWQVITDASVEV 446
Cdd:COG1033   636 LIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFL---SRYREERRK--------GGDLEEAIRRALRTT 704

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446496052  447 GPALFISLLIITLSFIP-IF-TLEGQegRLFGPLAftkTYAMAGAALLAIVVIPILMgYWIRGKIPPES 513
Cdd:COG1033   705 GKAILFTSLTLAAGFGVlLFsSFPPL--ADFGLLL---ALGLLVALLAALLLLPALL-LLLDPRIAKKR 767

MMPL

COG1033

Predicted exporter protein, RND superfamily [General function prediction only];

830-1047

4.13e-09

Predicted exporter protein, RND superfamily [General function prediction only];

Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 60.64 E-value: 4.13e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  830 DRDMVSVVHDLQKAIAEKVQlkPGTSVAFSGQF----ELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIISSVp 905
Cdd:COG1033   176 DLDRKEVVAEIRAIIAKYED--PGVEVYLTGFPvlrgDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVV- 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  906 faLVGGIW---LLWWMGFHLSVATGTGFIALAGVAAEFGVVMLMYLRHAIEAEPSlnnpqtfseqkLDEALYHgAVLRV- 981
Cdd:COG1033   253 --LLAVIWtlgLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYREERRKGLD-----------KREALRE-ALRKLg 318

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446496052  982 RPKAMTVAVIIAGLLPILWgtgAGSEVMSRIAAPMIGGMITAPLLSLFIIPAAykLMWLHRHRVRK 1047
Cdd:COG1033   319 PPVLLTSLTTAIGFLSLLF---SDIPPIRDFGIVAAIGVLLAFLTSLTLLPAL--LSLLPRPKPKT 379

actII

TIGR00833

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...

210-956

1.10e-08

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]

Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 59.21 E-value: 1.10e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   210 LDASNQEAGGSSIELaeaEYMVRasgyLQTLDDFNHIVLKASENGVPVYLRDVAKVQ--VG-PEMRRGIAelNGEGEVAG 286
Cdd:TIGR00833   49 MSAAFQEAIRDPKII---LVLES----NERLGDKDYATYDALIAKLRADIMHVISVVdfWGpPEAAEGLR--SDDGKATI 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   287 GVVILRSGKNAREVIAAVKD-KLETLKSSLPEGVEIV------TTYDRSQLIDRAIDNLSgklLEEFIVVAVVCALFLWH 359
Cdd:TIGR00833  120 IIVNLAGEKGQKEAQEAINAvRRIVEQTNAPDGLTVHvtgplaTIADILESGDKDMNRIT---ATTGIIVLIILLLVYRS 196

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   360 VRSALVAIISLPLGLCIAFIVM----HFQGLNANIMSLGGI-AIAVGAMVDAAIVMIENAHKRLEEwlHQHPDATLdnkt 434
Cdd:TIGR00833  197 PITMLVPLVSVGFSVVVAQGIVsllgIPGLIGVNAQTTVLLtALVIGAGTDYAVFLTGRYHEERRK--GESLEEAA---- 270

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   435 rwqviTDASVEVGPALFISLLIITLSFIPI-FTLEGQEGRLFGPLAFtktyAMAGAALLAIVVIPILMGYWIRGKIPPES 513
Cdd:TIGR00833  271 -----AEALRGTGKAILGSALTVAVAFLALsLARLPSFKTLGVSCAV----GVLVALLNAVTLTPALLTLEGREGLMKPG 341

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   514 SNPLNRFLIRVyhpLLLKVLHWPkTTLLVAALSVLTVLwplnkVGGEFLPQINEGDLLYMPSTLPGISAAEAAS------ 587
Cdd:TIGR00833  342 RKSKIRFIWRR---LGTAVVRRP-WPILVTTLIISGVS-----LLALPLIRTGYDDEKMIPTDLESVQGYEAADrhfpgn 412

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   588 ------MLQKTD----------------KLIMSVPEVARVFGKTGKAETATDSAPL---------EMVETTIQLKPQDQW 636
Cdd:TIGR00833  413 smdpmvVMIKSDhdvrnpalladidrfeREIKAVPGINMVQETQRPDGVVIKKTYLtfqagnlgdQLDEFSDQLTSRQAY 492

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   637 RPGM--TMDKIIEELDNTVRLPGLANLWVPPIRNRIDMLSTGIKSPIGIKVSGTVLADIDTMAEQIEEVARTVPGVASAL 714
Cdd:TIGR00833  493 LLQDaeKIAEAIAGLRLVQAGMRLDGENLGQVSLAVRLMQQAISKLQGSAGDVFDIFDPLRRFVAAIPECRANPVCSVAR 572

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   715 AerLEGGRYINVEINREKAARYGMTVADVQLFVTSAVGGAMVGETVEGIaryPINLRYPQSWRDSPQALRQLPILTPMKQ 794
Cdd:TIGR00833  573 E--IVQAADTVVSSAAKLADAAGQLARGIADVASALSQVSGLPNALDGI---GTQLAQMRESAAGVQDLLNELSDYSMTM 647

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   795 QITLADVADVKVSTGPSMLKTENARPTSWIYI---------------DARDRDMVSVVHDLQKAIAEKVQLK--PGTSVA 857
Cdd:TIGR00833  648 GKLKGNAMGVDFYAPPRIFTDPNFKAVLDYFLspdghaarllvygdgSPAGDQGAQEFNAIRTVAEEAIQRAdlEPAKVE 727

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   858 FSGQ----FELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIISSVPFALVG--GIWLLWW-----MGFHLSVAT 926
Cdd:TIGR00833  728 LAGVsavnRDLRDLVNSDLGLISIITLAIVFMILALLLRAPVAPIVLIGSVALSYLWalGLSVLAFqhilgAELHWSVLA 807

                          810       820       830
                   ....*....|....*....|....*....|
gi 446496052   927 GTgFIALAGVAAEFGVVMLMYLRHAIEAEP 956
Cdd:TIGR00833  808 GV-FVLLVALGVDYNMLLVSRIKEESPAGN 836

MMPL

COG1033

Predicted exporter protein, RND superfamily [General function prediction only];

827-1047

5.11e-08

Predicted exporter protein, RND superfamily [General function prediction only];

Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 57.18 E-value: 5.11e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  827 DARDRDMVSVVHDLQKAIAEKVQLkPGTSVAFSGQF----ELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIIS 902
Cdd:COG1033   559 DLDSEEIKALVEEVRAFLAENFPP-DGVEVTLTGSAvlfaAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLI 637

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  903 SVPFALVGGIWLLWWMGFHLSVATGTGF-IALaGVAAEFGVVMLMYLRHAIEAEPSlnnpqtfseqkLDEALYHgaVLRV 981
Cdd:COG1033   638 PNLLPILLTFGLMGLLGIPLNIATAVVAsIAL-GIGVDYTIHFLSRYREERRKGGD-----------LEEAIRR--ALRT 703

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446496052  982 RPKAMTV--AVIIAGLLPILWgtgAGSEVMSRIAAPMIGGMITAPLLSLFIIPAAykLMWLHRHRVRK 1047
Cdd:COG1033   704 TGKAILFtsLTLAAGFGVLLF---SSFPPLADFGLLLALGLLVALLAALLLLPAL--LLLLDPRIAKK 766

PRK15127

multidrug efflux RND transporter permease subunit AcrB;

6-500

9.77e-07

multidrug efflux RND transporter permease subunit AcrB;

Pssm-ID: 185081 [Multi-domain] Cd Length: 1049 Bit Score: 52.98 E-value: 9.77e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052    6 IRRSVAnRFLVLMgaLFLSIWGTWTIINTPVDALPDLSDVQVIIKTSYPGQAPQ----IVENQVT-YPLTTTMLSVPGAK 80
Cdd:PRK15127  534 ILRSTG-RYLVLY--LIIVVGMAYLFVRLPSSFLPDEDQGVFLTMVQLPAGATQertqKVLNEVTdYYLTKEKNNVESVF 610

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   81 TVRGFSQFG----DSYVYVIFEDGTDPYWARSRV-------LEYLNQVQG------KLPAGVsaELGpDATGvgwiYEYA 143
Cdd:PRK15127  611 AVNGFGFAGrgqnTGIAFVSLKDWADRPGEENKVeaitmraTRAFSQIKDamvfafNLPAIV--ELG-TATG----FDFE 683

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  144 LVDRSG-KHD-LADLRSLqdwfLKYELKTIPDVAEVASVGGV--VKEYQVVIDPQRLAQYGISLADVKSALDASnqeAGG 219
Cdd:PRK15127  684 LIDQAGlGHEkLTQARNQ----LLGEAAKHPDMLVGVRPNGLedTPQFKIDIDQEKAQALGVSISDINTTLGAA---WGG 756

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  220 SSIE------LAEAEYMVRASGYLQTLDDFNHIVLKASeNG--VPVYLRDVAKVQVG-PEMRR--GIAELNGEGEVAggv 288
Cdd:PRK15127  757 SYVNdfidrgRVKKVYVMSEAKYRMLPDDIGDWYVRAA-DGqmVPFSAFSSSRWEYGsPRLERynGLPSMEILGQAA--- 832

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  289 vilrSGKNAREVIAAvkdkLETLKSSLPEGVeivtTYDRSQLI--DRAIDNLSGKLLEEFIVVAVVCALFLWHVRS-ALV 365
Cdd:PRK15127  833 ----PGKSTGEAMEL----MEELASKLPTGV----GYDWTGMSyqERLSGNQAPALYAISLIVVFLCLAALYESWSiPFS 900

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052  366 AIISLPLGLCIAFIVMHFQGLNANIMSLGGIAIAVGAMVDAAIVMIENAHKRLEEWLHQHPDATLDNktrwqvitdASVE 445
Cdd:PRK15127  901 VMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGLIEATLEA---------VRMR 971

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 446496052  446 VGPALFISLLIItLSFIPIFTLEGQEGRLFGPLAFTKTYAMAGAALLAIVVIPIL 500
Cdd:PRK15127  972 LRPILMTSLAFI-LGVMPLVISSGAGSGAQNAVGTGVMGGMVTATVLAIFFVPVF 1025

2A067

TIGR00921

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...

827-1037

3.57e-05

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]

Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 47.91 E-value: 3.57e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   827 DARDRDMVSVVHDLQKAIaEKVQLKPGTSVAFSG----QFELLERANHKLKLMVPMTLMIIFVLLYLAFRRVGEALLIIS 902
Cdd:TIGR00921  147 DADYKQVVPIYNDVERSL-ERTNPPSGKFLDVTGspaiNYDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLV 225

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446496052   903 SVPFALVGGIWLLWWMGFHLSVATGTGFIALAGVAAEFGVVMLMYLRHAIEAEPSlnnpqtfSEQKLDEALYHGAVLRVR 982
Cdd:TIGR00921  226 IILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYEEERDIGRA-------KGEAIVTAVRRTGRAVLI 298

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 446496052   983 PKAMTVAVIIAGLLPILwgtgagsEVMSRIAAPMIGGMITAPLLSLFIIPAAYKL 1037
Cdd:TIGR00921  299 ALLTTSAGFAALALSEF-------PMVSEFGLGLVAGLITAYLLTLLVLPALLQS 346

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01